[{"abstract":[{"text":"Abstract\r\n Purpose\r\n Cardiopulmonary exercise testing (CPET) is considered the gold standard for assessing cardiorespiratory fitness. To ensure consistent performance of each test, it is necessary to adapt the power increase of the test protocol to the physical characteristics of each individual. This study aimed to use machine learning models to determine individualized ramp protocols based on non-exercise features. We hypothesized that machine learning models will predict peak oxygen uptake ($$\\dot{V}$$\r\n \r\n V\r\n ˙\r\n \r\n O2peak) and peak power output (PPO) more accurately than conventional multiple linear regression (MLR).\r\n \r\n Methods\r\n The cross-sectional study was conducted with 274 (♀168, ♂106) participants who performed CPET on a cycle ergometer. Machine learning models and multiple linear regression were used to predict $$\\dot{V}$$\r\n \r\n V\r\n ˙\r\n \r\n O2peak and PPO using non-exercise features. The accuracy of the models was compared using criteria such as root mean square error (RMSE). Shapley additive explanation (SHAP) was applied to determine the feature importance.\r\n \r\n Results\r\n The most accurate machine learning model was the random forest (RMSE: 6.52 ml/kg/min [95% CI 5.21–8.17]) for $$\\dot{V}$$\r\n \r\n V\r\n ˙\r\n \r\n O2peak prediction and the gradient boosting regression (RMSE: 43watts [95% CI 35–52]) for PPO prediction. Compared to the MLR, the machine learning models reduced the RMSE by up to 28% and 22% for prediction of $$\\dot{V}$$\r\n \r\n V\r\n ˙\r\n \r\n O2peak and PPO, respectively. Furthermore, SHAP ranked body composition data such as skeletal muscle mass and extracellular water as the most impactful features.\r\n \r\n Conclusion\r\n Machine learning models predict $$\\dot{V}$$\r\n \r\n V\r\n ˙\r\n \r\n O2peak and PPO more accurately than MLR and can be used to individualize CPET protocols. Features that provide information about the participant's body composition contribute most to the improvement of these predictions.\r\n \r\n Trial registration number\r\n DRKS00031401 (6 March 2023, retrospectively registered).\r\n ","lang":"eng"}],"status":"public","publication":"European Journal of Applied Physiology","type":"journal_article","extern":"1","language":[{"iso":"eng"}],"_id":"60047","user_id":"117661","year":"2024","page":"3421-3431","intvolume":" 124","citation":{"bibtex":"@article{Wenzel_Liebig_Swoboda_Smolareck_Schlagheck_Walzik_Groll_Goulding_Zimmer_2024, title={Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features}, volume={124}, DOI={10.1007/s00421-024-05543-x}, number={11}, journal={European Journal of Applied Physiology}, publisher={Springer Science and Business Media LLC}, author={Wenzel, Charlotte and Liebig, Thomas and Swoboda, Adrian and Smolareck, Rika and Schlagheck, Marit Lea and Walzik, David and Groll, Andreas and Goulding, Richie P. and Zimmer, Philipp}, year={2024}, pages={3421–3431} }","short":"C. Wenzel, T. Liebig, A. Swoboda, R. Smolareck, M.L. Schlagheck, D. Walzik, A. Groll, R.P. Goulding, P. Zimmer, European Journal of Applied Physiology 124 (2024) 3421–3431.","mla":"Wenzel, Charlotte, et al. “Machine Learning Predicts Peak Oxygen Uptake and Peak Power Output for Customizing Cardiopulmonary Exercise Testing Using Non-Exercise Features.” European Journal of Applied Physiology, vol. 124, no. 11, Springer Science and Business Media LLC, 2024, pp. 3421–31, doi:10.1007/s00421-024-05543-x.","apa":"Wenzel, C., Liebig, T., Swoboda, A., Smolareck, R., Schlagheck, M. L., Walzik, D., Groll, A., Goulding, R. P., & Zimmer, P. (2024). Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features. European Journal of Applied Physiology, 124(11), 3421–3431. https://doi.org/10.1007/s00421-024-05543-x","ieee":"C. Wenzel et al., “Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features,” European Journal of Applied Physiology, vol. 124, no. 11, pp. 3421–3431, 2024, doi: 10.1007/s00421-024-05543-x.","chicago":"Wenzel, Charlotte, Thomas Liebig, Adrian Swoboda, Rika Smolareck, Marit Lea Schlagheck, David Walzik, Andreas Groll, Richie P. Goulding, and Philipp Zimmer. “Machine Learning Predicts Peak Oxygen Uptake and Peak Power Output for Customizing Cardiopulmonary Exercise Testing Using Non-Exercise Features.” European Journal of Applied Physiology 124, no. 11 (2024): 3421–31. https://doi.org/10.1007/s00421-024-05543-x.","ama":"Wenzel C, Liebig T, Swoboda A, et al. Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features. European Journal of Applied Physiology. 2024;124(11):3421-3431. doi:10.1007/s00421-024-05543-x"},"publication_identifier":{"issn":["1439-6319","1439-6327"]},"publication_status":"published","issue":"11","title":"Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features","doi":"10.1007/s00421-024-05543-x","publisher":"Springer Science and Business Media LLC","date_updated":"2025-06-02T09:34:21Z","volume":124,"date_created":"2025-05-27T07:54:52Z","author":[{"first_name":"Charlotte","full_name":"Wenzel, Charlotte","last_name":"Wenzel"},{"full_name":"Liebig, Thomas","last_name":"Liebig","first_name":"Thomas"},{"first_name":"Adrian","last_name":"Swoboda","full_name":"Swoboda, Adrian"},{"first_name":"Rika","full_name":"Smolareck, Rika","last_name":"Smolareck"},{"id":"117661","full_name":"Schlagheck, Marit Lea","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","first_name":"Marit Lea"},{"last_name":"Walzik","full_name":"Walzik, David","first_name":"David"},{"first_name":"Andreas","full_name":"Groll, Andreas","last_name":"Groll"},{"first_name":"Richie P.","last_name":"Goulding","full_name":"Goulding, Richie P."},{"last_name":"Zimmer","full_name":"Zimmer, Philipp","first_name":"Philipp"}]},{"language":[{"iso":"eng"}],"abstract":[{"text":"Abstract\r\n Purpose\r\n Research supports physical activity as a method to heighten stress resistance and resilience through positive metabolic alterations mostly affecting the neuroendocrine system. High-intensity interval training (HIIT) has been proposed as a highly effective time-saving method to induce those changes. However, existing literature relies heavily on cross-sectional analyses, with few randomised controlled trials highlighting the necessity for more exercise interventions. Thus, this study aims to investigate the effects of HIIT versus an active control group on the stress response to an acute psychosocial stressor in emotionally impulsive humans (suggested as being strong stress responders).\r\n \r\n Methods\r\n The study protocol was registered online (DRKS00016589) before data collection. Sedentary, emotionally impulsive adults (30.69 ± 8.20 y) were recruited for a supervised intervention of 8 weeks and randomly allocated to either a HIIT (n = 25) or a stretching group (n = 19, acting as active controls). Participants were submitted to a test battery, including saliva samples, questionnaires (self-efficacy- and perceived stress-related), visual analogue scales (physical exercise- and stress-related), and resting electroencephalography and electrocardiography assessing their reaction to an acute psychological stressor (Trier Social Stress Test) before and after the exercise intervention.\r\n \r\n Results\r\n HIIT increased aerobic fitness in all participants, whereas stretching did not. Participants from the HIIT group reported perceiving exercising more intensively than those from the active control group (ƞp2 = 0.108, p = 0.038). No further group differences were detected. Both interventions largely increased levels of joy post-TSST (ƞp2 = 0.209, p = 0.003) whilst decreasing tension (ƞp2 = 0.262, p < 0.001) and worries (ƞp2 = 0.113, p = 0.037). Finally, both interventions largely increased perceived levels of general self-efficacy (ƞp2 = 0.120, p = 0.029).\r\n \r\n Conclusion\r\n This study suggests that 8 weeks of HIIT does not change the psychoneuroendocrine response to an acute psychological stress test compared to an active control group in emotionally impulsive humans. Further replications of supervised exercise studies highly powered with active and passive controls are warranted.\r\n ","lang":"eng"}],"publication":"European Journal of Applied Physiology","title":"Eight weeks of high-intensity interval training versus stretching do not change the psychoneuroendocrine response to a social stress test in emotionally impulsive humans","date_created":"2025-06-02T09:43:08Z","publisher":"Springer Science and Business Media LLC","year":"2024","issue":"10","extern":"1","user_id":"117661","_id":"60092","status":"public","type":"journal_article","doi":"10.1007/s00421-024-05471-w","author":[{"last_name":"Javelle","full_name":"Javelle, F.","first_name":"F."},{"first_name":"W.","last_name":"Bloch","full_name":"Bloch, W."},{"last_name":"Borges","full_name":"Borges, U.","first_name":"U."},{"first_name":"T.","last_name":"Burberg","full_name":"Burberg, T."},{"last_name":"Collins","full_name":"Collins, B.","first_name":"B."},{"last_name":"Gunasekara","full_name":"Gunasekara, N.","first_name":"N."},{"full_name":"Hosang, T. J.","last_name":"Hosang","first_name":"T. J."},{"full_name":"Jacobsen, T.","last_name":"Jacobsen","first_name":"T."},{"first_name":"S.","last_name":"Laborde","full_name":"Laborde, S."},{"first_name":"A.","full_name":"Löw, A.","last_name":"Löw"},{"full_name":"Schenk, A.","last_name":"Schenk","first_name":"A."},{"first_name":"Marit Lea","orcid":"0000-0002-8913-6080 ","last_name":"Schlagheck","id":"117661","full_name":"Schlagheck, Marit Lea"},{"full_name":"Schoser, D.","last_name":"Schoser","first_name":"D."},{"last_name":"Vogel","full_name":"Vogel, A.","first_name":"A."},{"first_name":"D.","full_name":"Walzik, D.","last_name":"Walzik"},{"full_name":"Zimmer, P.","last_name":"Zimmer","first_name":"P."}],"volume":124,"date_updated":"2025-06-02T09:44:49Z","citation":{"apa":"Javelle, F., Bloch, W., Borges, U., Burberg, T., Collins, B., Gunasekara, N., Hosang, T. J., Jacobsen, T., Laborde, S., Löw, A., Schenk, A., Schlagheck, M. L., Schoser, D., Vogel, A., Walzik, D., & Zimmer, P. (2024). Eight weeks of high-intensity interval training versus stretching do not change the psychoneuroendocrine response to a social stress test in emotionally impulsive humans. European Journal of Applied Physiology, 124(10), 2893–2908. https://doi.org/10.1007/s00421-024-05471-w","mla":"Javelle, F., et al. “Eight Weeks of High-Intensity Interval Training versus Stretching Do Not Change the Psychoneuroendocrine Response to a Social Stress Test in Emotionally Impulsive Humans.” European Journal of Applied Physiology, vol. 124, no. 10, Springer Science and Business Media LLC, 2024, pp. 2893–908, doi:10.1007/s00421-024-05471-w.","short":"F. Javelle, W. Bloch, U. Borges, T. Burberg, B. Collins, N. Gunasekara, T.J. Hosang, T. Jacobsen, S. Laborde, A. Löw, A. Schenk, M.L. Schlagheck, D. Schoser, A. Vogel, D. Walzik, P. Zimmer, European Journal of Applied Physiology 124 (2024) 2893–2908.","bibtex":"@article{Javelle_Bloch_Borges_Burberg_Collins_Gunasekara_Hosang_Jacobsen_Laborde_Löw_et al._2024, title={Eight weeks of high-intensity interval training versus stretching do not change the psychoneuroendocrine response to a social stress test in emotionally impulsive humans}, volume={124}, DOI={10.1007/s00421-024-05471-w}, number={10}, journal={European Journal of Applied Physiology}, publisher={Springer Science and Business Media LLC}, author={Javelle, F. and Bloch, W. and Borges, U. and Burberg, T. and Collins, B. and Gunasekara, N. and Hosang, T. J. and Jacobsen, T. and Laborde, S. and Löw, A. and et al.}, year={2024}, pages={2893–2908} }","ieee":"F. Javelle et al., “Eight weeks of high-intensity interval training versus stretching do not change the psychoneuroendocrine response to a social stress test in emotionally impulsive humans,” European Journal of Applied Physiology, vol. 124, no. 10, pp. 2893–2908, 2024, doi: 10.1007/s00421-024-05471-w.","chicago":"Javelle, F., W. Bloch, U. Borges, T. Burberg, B. Collins, N. Gunasekara, T. J. Hosang, et al. “Eight Weeks of High-Intensity Interval Training versus Stretching Do Not Change the Psychoneuroendocrine Response to a Social Stress Test in Emotionally Impulsive Humans.” European Journal of Applied Physiology 124, no. 10 (2024): 2893–2908. https://doi.org/10.1007/s00421-024-05471-w.","ama":"Javelle F, Bloch W, Borges U, et al. Eight weeks of high-intensity interval training versus stretching do not change the psychoneuroendocrine response to a social stress test in emotionally impulsive humans. European Journal of Applied Physiology. 2024;124(10):2893-2908. doi:10.1007/s00421-024-05471-w"},"page":"2893-2908","intvolume":" 124","publication_status":"published","publication_identifier":{"issn":["1439-6319","1439-6327"]}},{"_id":"60093","user_id":"117661","extern":"1","language":[{"iso":"eng"}],"publication":"Brain, Behavior, and Immunity","type":"journal_article","status":"public","date_updated":"2025-06-02T09:53:19Z","publisher":"Elsevier BV","volume":124,"date_created":"2025-06-02T09:48:43Z","author":[{"first_name":"Sebastian","last_name":"Proschinger","full_name":"Proschinger, Sebastian"},{"first_name":"Sergen","last_name":"Belen","full_name":"Belen, Sergen"},{"first_name":"Frederike","last_name":"Adammek","full_name":"Adammek, Frederike"},{"first_name":"Marit Lea","id":"117661","full_name":"Schlagheck, Marit Lea","orcid":"0000-0002-8913-6080 ","last_name":"Schlagheck"},{"first_name":"Annette","last_name":"Rademacher","full_name":"Rademacher, Annette"},{"last_name":"Schenk","full_name":"Schenk, Alexander","first_name":"Alexander"},{"last_name":"Warnke","full_name":"Warnke, Clemens","first_name":"Clemens"},{"first_name":"Wilhelm","last_name":"Bloch","full_name":"Bloch, Wilhelm"},{"first_name":"Philipp","last_name":"Zimmer","full_name":"Zimmer, Philipp"}],"title":"Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial","doi":"10.1016/j.bbi.2024.12.017","publication_identifier":{"issn":["0889-1591"]},"publication_status":"published","year":"2024","page":"397-408","intvolume":" 124","citation":{"apa":"Proschinger, S., Belen, S., Adammek, F., Schlagheck, M. L., Rademacher, A., Schenk, A., Warnke, C., Bloch, W., & Zimmer, P. (2024). Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial. Brain, Behavior, and Immunity, 124, 397–408. https://doi.org/10.1016/j.bbi.2024.12.017","short":"S. Proschinger, S. Belen, F. Adammek, M.L. Schlagheck, A. Rademacher, A. Schenk, C. Warnke, W. Bloch, P. Zimmer, Brain, Behavior, and Immunity 124 (2024) 397–408.","mla":"Proschinger, Sebastian, et al. “Sportizumab – Multimodal Progressive Exercise over 10 Weeks Decreases Th17 Frequency and CD49d Expression on CD8+ T Cells in Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial.” Brain, Behavior, and Immunity, vol. 124, Elsevier BV, 2024, pp. 397–408, doi:10.1016/j.bbi.2024.12.017.","bibtex":"@article{Proschinger_Belen_Adammek_Schlagheck_Rademacher_Schenk_Warnke_Bloch_Zimmer_2024, title={Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial}, volume={124}, DOI={10.1016/j.bbi.2024.12.017}, journal={Brain, Behavior, and Immunity}, publisher={Elsevier BV}, author={Proschinger, Sebastian and Belen, Sergen and Adammek, Frederike and Schlagheck, Marit Lea and Rademacher, Annette and Schenk, Alexander and Warnke, Clemens and Bloch, Wilhelm and Zimmer, Philipp}, year={2024}, pages={397–408} }","ieee":"S. Proschinger et al., “Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial,” Brain, Behavior, and Immunity, vol. 124, pp. 397–408, 2024, doi: 10.1016/j.bbi.2024.12.017.","chicago":"Proschinger, Sebastian, Sergen Belen, Frederike Adammek, Marit Lea Schlagheck, Annette Rademacher, Alexander Schenk, Clemens Warnke, Wilhelm Bloch, and Philipp Zimmer. “Sportizumab – Multimodal Progressive Exercise over 10 Weeks Decreases Th17 Frequency and CD49d Expression on CD8+ T Cells in Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial.” Brain, Behavior, and Immunity 124 (2024): 397–408. https://doi.org/10.1016/j.bbi.2024.12.017.","ama":"Proschinger S, Belen S, Adammek F, et al. Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial. Brain, Behavior, and Immunity. 2024;124:397-408. doi:10.1016/j.bbi.2024.12.017"}},{"doi":"10.1016/j.msard.2024.105826","title":"Predictors of six-month change in health-related quality of life in people with multiple sclerosis: A secondary data analysis of a randomized controlled trial","author":[{"last_name":"Patt","full_name":"Patt, Nadine","first_name":"Nadine"},{"first_name":"Marie","last_name":"Kupjetz","full_name":"Kupjetz, Marie"},{"orcid":"0000-0002-8913-6080 ","last_name":"Schlagheck","id":"117661","full_name":"Schlagheck, Marit Lea","first_name":"Marit Lea"},{"last_name":"Hersche","full_name":"Hersche, Ruth","first_name":"Ruth"},{"last_name":"Joisten","full_name":"Joisten, Niklas","first_name":"Niklas"},{"last_name":"Kool","full_name":"Kool, Jan","first_name":"Jan"},{"first_name":"Roman","full_name":"Gonzenbach, Roman","last_name":"Gonzenbach"},{"first_name":"Claudio R.","last_name":"Nigg","full_name":"Nigg, Claudio R."},{"last_name":"Zimmer","full_name":"Zimmer, Philipp","first_name":"Philipp"},{"last_name":"Bansi","full_name":"Bansi, Jens","first_name":"Jens"}],"date_created":"2025-06-02T09:49:06Z","volume":90,"publisher":"Elsevier BV","date_updated":"2025-06-02T09:53:01Z","citation":{"chicago":"Patt, Nadine, Marie Kupjetz, Marit Lea Schlagheck, Ruth Hersche, Niklas Joisten, Jan Kool, Roman Gonzenbach, Claudio R. Nigg, Philipp Zimmer, and Jens Bansi. “Predictors of Six-Month Change in Health-Related Quality of Life in People with Multiple Sclerosis: A Secondary Data Analysis of a Randomized Controlled Trial.” Multiple Sclerosis and Related Disorders 90 (2024). https://doi.org/10.1016/j.msard.2024.105826.","ieee":"N. Patt et al., “Predictors of six-month change in health-related quality of life in people with multiple sclerosis: A secondary data analysis of a randomized controlled trial,” Multiple Sclerosis and Related Disorders, vol. 90, Art. no. 105826, 2024, doi: 10.1016/j.msard.2024.105826.","ama":"Patt N, Kupjetz M, Schlagheck ML, et al. Predictors of six-month change in health-related quality of life in people with multiple sclerosis: A secondary data analysis of a randomized controlled trial. Multiple Sclerosis and Related Disorders. 2024;90. doi:10.1016/j.msard.2024.105826","bibtex":"@article{Patt_Kupjetz_Schlagheck_Hersche_Joisten_Kool_Gonzenbach_Nigg_Zimmer_Bansi_2024, title={Predictors of six-month change in health-related quality of life in people with multiple sclerosis: A secondary data analysis of a randomized controlled trial}, volume={90}, DOI={10.1016/j.msard.2024.105826}, number={105826}, journal={Multiple Sclerosis and Related Disorders}, publisher={Elsevier BV}, author={Patt, Nadine and Kupjetz, Marie and Schlagheck, Marit Lea and Hersche, Ruth and Joisten, Niklas and Kool, Jan and Gonzenbach, Roman and Nigg, Claudio R. and Zimmer, Philipp and Bansi, Jens}, year={2024} }","mla":"Patt, Nadine, et al. “Predictors of Six-Month Change in Health-Related Quality of Life in People with Multiple Sclerosis: A Secondary Data Analysis of a Randomized Controlled Trial.” Multiple Sclerosis and Related Disorders, vol. 90, 105826, Elsevier BV, 2024, doi:10.1016/j.msard.2024.105826.","short":"N. Patt, M. Kupjetz, M.L. Schlagheck, R. Hersche, N. Joisten, J. Kool, R. Gonzenbach, C.R. Nigg, P. Zimmer, J. Bansi, Multiple Sclerosis and Related Disorders 90 (2024).","apa":"Patt, N., Kupjetz, M., Schlagheck, M. L., Hersche, R., Joisten, N., Kool, J., Gonzenbach, R., Nigg, C. R., Zimmer, P., & Bansi, J. (2024). Predictors of six-month change in health-related quality of life in people with multiple sclerosis: A secondary data analysis of a randomized controlled trial. Multiple Sclerosis and Related Disorders, 90, Article 105826. https://doi.org/10.1016/j.msard.2024.105826"},"intvolume":" 90","year":"2024","publication_status":"published","publication_identifier":{"issn":["2211-0348"]},"extern":"1","language":[{"iso":"eng"}],"article_number":"105826","user_id":"117661","_id":"60094","status":"public","type":"journal_article","publication":"Multiple Sclerosis and Related Disorders"},{"publisher":"Wiley","date_created":"2025-05-27T07:54:42Z","title":"Complexity and pitfalls in maximal exercise testing for persons with multiple sclerosis","issue":"9","year":"2023","language":[{"iso":"eng"}],"publication":"European Journal of Neurology","abstract":[{"text":"AbstractBackground and purposeValid measurements of cardiorespiratory fitness in persons with multiple sclerosis (pwMS) are essential during inpatient rehabilitation for a precise evaluation of the current health status, for defining appropriate exercise intensities, and for evaluation of exercise intervention studies. We aim (i) to examine the proportion of pwMS who attain the American College of Sports Medicine (ACSM) criteria for maximal effort during graded cardiopulmonary exercise testing (CPET) and (ii) to provide insight into participant characteristics that limit maximal exercise performance.MethodsThis cross‐sectional study comprises a retrospective examination of ACSM criteria for maximal effort during graded CPET of n = 380 inpatient pwMS (mean age = 48 ± 11 years, 66% female). Chi‐squared or Fisher's exact tests were conducted to compare differences in the distribution of criteria achieved. Participants' characteristics were examined as potential predictors using binary logistic regression.ResultsOnly 60% of the overall sample attained a respiratory exchange ratio ≥ 1.10. With regard to the definition applied, only 24% or 40% of the participants achieved an oxygen consumption plateau, and 17% or 50% attained the heart rate criterion. Forty‐six percent met at least two of three criteria. Disability status, gender, disease course, and body mass index were associated with the attainment of maximal effort.ConclusionsOur findings suggest that a relevant proportion of inpatient pwMS do not attain common criteria utilized to verify maximal oxygen consumption. Identified predictors for criteria attainment can be used to create models to predict cardiorespiratory fitness and to optimize CPET protocols in restrictive groups of pwMS.","lang":"eng"}],"date_updated":"2025-06-02T09:34:01Z","volume":30,"author":[{"full_name":"Schlagheck, Marit Lea","id":"117661","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","first_name":"Marit Lea"},{"full_name":"Bansi, Jens","last_name":"Bansi","first_name":"Jens"},{"first_name":"Charlotte","last_name":"Wenzel","full_name":"Wenzel, Charlotte"},{"first_name":"Marina","full_name":"Kuzdas‐Sallaberger, Marina","last_name":"Kuzdas‐Sallaberger"},{"last_name":"Kiesl","full_name":"Kiesl, David","first_name":"David"},{"last_name":"Gonzenbach","full_name":"Gonzenbach, Roman","first_name":"Roman"},{"full_name":"Zimmer, Philipp","last_name":"Zimmer","first_name":"Philipp"}],"doi":"10.1111/ene.15875","publication_identifier":{"issn":["1351-5101","1468-1331"]},"publication_status":"published","intvolume":" 30","page":"2726-2735","citation":{"ama":"Schlagheck ML, Bansi J, Wenzel C, et al. Complexity and pitfalls in maximal exercise testing for persons with multiple sclerosis. European Journal of Neurology. 2023;30(9):2726-2735. doi:10.1111/ene.15875","chicago":"Schlagheck, Marit Lea, Jens Bansi, Charlotte Wenzel, Marina Kuzdas‐Sallaberger, David Kiesl, Roman Gonzenbach, and Philipp Zimmer. “Complexity and Pitfalls in Maximal Exercise Testing for Persons with Multiple Sclerosis.” European Journal of Neurology 30, no. 9 (2023): 2726–35. https://doi.org/10.1111/ene.15875.","ieee":"M. L. Schlagheck et al., “Complexity and pitfalls in maximal exercise testing for persons with multiple sclerosis,” European Journal of Neurology, vol. 30, no. 9, pp. 2726–2735, 2023, doi: 10.1111/ene.15875.","short":"M.L. Schlagheck, J. Bansi, C. Wenzel, M. Kuzdas‐Sallaberger, D. Kiesl, R. Gonzenbach, P. Zimmer, European Journal of Neurology 30 (2023) 2726–2735.","bibtex":"@article{Schlagheck_Bansi_Wenzel_Kuzdas‐Sallaberger_Kiesl_Gonzenbach_Zimmer_2023, title={Complexity and pitfalls in maximal exercise testing for persons with multiple sclerosis}, volume={30}, DOI={10.1111/ene.15875}, number={9}, journal={European Journal of Neurology}, publisher={Wiley}, author={Schlagheck, Marit Lea and Bansi, Jens and Wenzel, Charlotte and Kuzdas‐Sallaberger, Marina and Kiesl, David and Gonzenbach, Roman and Zimmer, Philipp}, year={2023}, pages={2726–2735} }","mla":"Schlagheck, Marit Lea, et al. “Complexity and Pitfalls in Maximal Exercise Testing for Persons with Multiple Sclerosis.” European Journal of Neurology, vol. 30, no. 9, Wiley, 2023, pp. 2726–35, doi:10.1111/ene.15875.","apa":"Schlagheck, M. L., Bansi, J., Wenzel, C., Kuzdas‐Sallaberger, M., Kiesl, D., Gonzenbach, R., & Zimmer, P. (2023). Complexity and pitfalls in maximal exercise testing for persons with multiple sclerosis. European Journal of Neurology, 30(9), 2726–2735. https://doi.org/10.1111/ene.15875"},"_id":"60046","user_id":"117661","extern":"1","type":"journal_article","status":"public"},{"year":"2023","intvolume":" 14","citation":{"ama":"Schlagheck ML, Hübner ST, Joisten N, et al. Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis – a self-reported questionnaire based study. Frontiers in Neurology. 2023;14. doi:10.3389/fneur.2023.1217000","ieee":"M. L. Schlagheck et al., “Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis – a self-reported questionnaire based study,” Frontiers in Neurology, vol. 14, 2023, doi: 10.3389/fneur.2023.1217000.","chicago":"Schlagheck, Marit Lea, Sven T. Hübner, Niklas Joisten, David Walzik, Annette Rademacher, Florian Wolf, Jens Bansi, Clemens Warnke, and Philipp Zimmer. “Physical Activity Is Related to Disease Severity and Fatigue, but Not to Relapse Rate in Persons with Relapsing Remitting Multiple Sclerosis – a Self-Reported Questionnaire Based Study.” Frontiers in Neurology 14 (2023). https://doi.org/10.3389/fneur.2023.1217000.","short":"M.L. Schlagheck, S.T. Hübner, N. Joisten, D. Walzik, A. Rademacher, F. Wolf, J. Bansi, C. Warnke, P. Zimmer, Frontiers in Neurology 14 (2023).","mla":"Schlagheck, Marit Lea, et al. “Physical Activity Is Related to Disease Severity and Fatigue, but Not to Relapse Rate in Persons with Relapsing Remitting Multiple Sclerosis – a Self-Reported Questionnaire Based Study.” Frontiers in Neurology, vol. 14, Frontiers Media SA, 2023, doi:10.3389/fneur.2023.1217000.","bibtex":"@article{Schlagheck_Hübner_Joisten_Walzik_Rademacher_Wolf_Bansi_Warnke_Zimmer_2023, title={Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis – a self-reported questionnaire based study}, volume={14}, DOI={10.3389/fneur.2023.1217000}, journal={Frontiers in Neurology}, publisher={Frontiers Media SA}, author={Schlagheck, Marit Lea and Hübner, Sven T. and Joisten, Niklas and Walzik, David and Rademacher, Annette and Wolf, Florian and Bansi, Jens and Warnke, Clemens and Zimmer, Philipp}, year={2023} }","apa":"Schlagheck, M. L., Hübner, S. T., Joisten, N., Walzik, D., Rademacher, A., Wolf, F., Bansi, J., Warnke, C., & Zimmer, P. (2023). Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis – a self-reported questionnaire based study. Frontiers in Neurology, 14. https://doi.org/10.3389/fneur.2023.1217000"},"publication_identifier":{"issn":["1664-2295"]},"publication_status":"published","title":"Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis – a self-reported questionnaire based study","doi":"10.3389/fneur.2023.1217000","publisher":"Frontiers Media SA","date_updated":"2025-06-02T09:47:09Z","volume":14,"date_created":"2025-06-02T09:36:45Z","author":[{"first_name":"Marit Lea","id":"117661","full_name":"Schlagheck, Marit Lea","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 "},{"full_name":"Hübner, Sven T.","last_name":"Hübner","first_name":"Sven T."},{"first_name":"Niklas","full_name":"Joisten, Niklas","last_name":"Joisten"},{"first_name":"David","full_name":"Walzik, David","last_name":"Walzik"},{"full_name":"Rademacher, Annette","last_name":"Rademacher","first_name":"Annette"},{"full_name":"Wolf, Florian","last_name":"Wolf","first_name":"Florian"},{"first_name":"Jens","full_name":"Bansi, Jens","last_name":"Bansi"},{"first_name":"Clemens","full_name":"Warnke, Clemens","last_name":"Warnke"},{"first_name":"Philipp","full_name":"Zimmer, Philipp","last_name":"Zimmer"}],"abstract":[{"lang":"eng","text":"IntroductionBased on theoretical models, physical activity has been introduced as a promoting method to mitigate the disease severity, fatigue and relapse rate in multiple sclerosis. The primary objective of the study was to investigate the relation between self-reported physical activity level and disease severity, fatigue and relapse rate in persons with relapsing remitting multiple sclerosis (RRMS).MethodsA survey was offered to persons with RRMS from March 2019 to August 2021 (n = 253). Physical activity level, fatigue and disease severity were determined using the Godin Leisure-Time Questionnaire (GLTEQ), the Patient Determined Disease Steps (PDDS) scale and the Fatigue Scale for Motor and Cognitive Functions (FSMC). Additionally, participants’ relapse rate was recorded.ResultsBivariate correlations revealed an inverse relation between physical activity level and PDDS (ρ = −0.279; p < 0.001) as well as between physical activity and FSMC (r = −0.213, p < 0.001), but not between physical activity and relapse rate (r = 0.033, p > 0.05). Multiple linear regression analyses explained 12.6% and 5.2% of the variance of PDDS and FSMC.ConclusionOur findings confirm a relation between self-reported physical activity, disease severity and fatigue in persons with RRMS. However, self-reported physical activity level does not seem to affect the annualised relapse rate."}],"status":"public","publication":"Frontiers in Neurology","type":"journal_article","extern":"1","language":[{"iso":"eng"}],"_id":"60087","user_id":"117661"},{"publisher":"Elsevier BV","date_updated":"2025-06-02T09:45:06Z","date_created":"2025-06-02T09:42:26Z","author":[{"last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","full_name":"Schlagheck, Marit Lea","id":"117661","first_name":"Marit Lea"},{"first_name":"Jens","last_name":"Bansi","full_name":"Bansi, Jens"},{"first_name":"Martin","full_name":"Langeskov-Christensen, Martin","last_name":"Langeskov-Christensen"},{"full_name":"Zimmer, Philipp","last_name":"Zimmer","first_name":"Philipp"},{"last_name":"Hvid","full_name":"Hvid, Lars G.","first_name":"Lars G."}],"volume":27,"title":"Cardiorespiratory fitness (V̇O2peak) across the adult lifespan in persons with multiple sclerosis and matched healthy controls","doi":"10.1016/j.jsams.2023.10.009","publication_status":"published","publication_identifier":{"issn":["1440-2440"]},"issue":"1","year":"2023","citation":{"apa":"Schlagheck, M. L., Bansi, J., Langeskov-Christensen, M., Zimmer, P., & Hvid, L. G. (2023). Cardiorespiratory fitness (V̇O2peak) across the adult lifespan in persons with multiple sclerosis and matched healthy controls. Journal of Science and Medicine in Sport, 27(1), 10–15. https://doi.org/10.1016/j.jsams.2023.10.009","short":"M.L. Schlagheck, J. Bansi, M. Langeskov-Christensen, P. Zimmer, L.G. Hvid, Journal of Science and Medicine in Sport 27 (2023) 10–15.","mla":"Schlagheck, Marit Lea, et al. “Cardiorespiratory Fitness (V̇O2peak) across the Adult Lifespan in Persons with Multiple Sclerosis and Matched Healthy Controls.” Journal of Science and Medicine in Sport, vol. 27, no. 1, Elsevier BV, 2023, pp. 10–15, doi:10.1016/j.jsams.2023.10.009.","bibtex":"@article{Schlagheck_Bansi_Langeskov-Christensen_Zimmer_Hvid_2023, title={Cardiorespiratory fitness (V̇O2peak) across the adult lifespan in persons with multiple sclerosis and matched healthy controls}, volume={27}, DOI={10.1016/j.jsams.2023.10.009}, number={1}, journal={Journal of Science and Medicine in Sport}, publisher={Elsevier BV}, author={Schlagheck, Marit Lea and Bansi, Jens and Langeskov-Christensen, Martin and Zimmer, Philipp and Hvid, Lars G.}, year={2023}, pages={10–15} }","ama":"Schlagheck ML, Bansi J, Langeskov-Christensen M, Zimmer P, Hvid LG. Cardiorespiratory fitness (V̇O2peak) across the adult lifespan in persons with multiple sclerosis and matched healthy controls. Journal of Science and Medicine in Sport. 2023;27(1):10-15. doi:10.1016/j.jsams.2023.10.009","ieee":"M. L. Schlagheck, J. Bansi, M. Langeskov-Christensen, P. Zimmer, and L. G. Hvid, “Cardiorespiratory fitness (V̇O2peak) across the adult lifespan in persons with multiple sclerosis and matched healthy controls,” Journal of Science and Medicine in Sport, vol. 27, no. 1, pp. 10–15, 2023, doi: 10.1016/j.jsams.2023.10.009.","chicago":"Schlagheck, Marit Lea, Jens Bansi, Martin Langeskov-Christensen, Philipp Zimmer, and Lars G. Hvid. “Cardiorespiratory Fitness (V̇O2peak) across the Adult Lifespan in Persons with Multiple Sclerosis and Matched Healthy Controls.” Journal of Science and Medicine in Sport 27, no. 1 (2023): 10–15. https://doi.org/10.1016/j.jsams.2023.10.009."},"intvolume":" 27","page":"10-15","_id":"60091","user_id":"117661","extern":"1","language":[{"iso":"eng"}],"type":"journal_article","publication":"Journal of Science and Medicine in Sport","status":"public"},{"publication":"European Journal of Pediatrics","type":"journal_article","status":"public","abstract":[{"lang":"eng","text":"AbstractEndurance training has been shown to be effective in treating adolescents with major depressive disorder (MDD). To integrate endurance training into the therapeutic setting and the adolescents' daily lives, the current performance status of the adolescents should be accurately assessed. This study aims to examine adolescents with MDD concerning exhaustion criteria during a cardiopulmonary exercise test (CPET), as well as to compare the values obtained thereon with sex- and age-related control values. The study included a retrospective examination of exhaustion criteria ((i) oxygen consumption (V̇O2) plateau, (ii) peak respiratory exchange ratio (RERpeak) > 1.0, (iii) peak heart rate (HRpeak) ≥ 95% of the age-predicted maximal HR, and (iv) peak blood lactate concentration (BLCpeak) > 8.0 mmol⋅L−1) during a graded CPET on a cycle ergometer in adolescents with MDD (n = 57). Subsequently, maximal V̇O2, peak minute ventilation, V̇O2 at the first ventilatory threshold, and peak work rate of participants who met at least two of four criteria were compared with published control values using an independent-sample t-test. Thirty-three percent of the total population achieved a V̇O2 plateau and 75% a RERpeak > 1.0. The HR and BLC criteria were met by 19% and 22%, respectively. T-test results revealed significant differences between adolescents with MDD and control values for all outcomes. Adolescents with MDD achieved between 56% and 83% of control values. Conclusions: The study shows that compared with control values, fewer adolescents with MDD achieve the exhaustion criteria on a CPET and adolescents with MDD have significantly lower cardiorespiratory fitness. Clinical trial registration: No. U1111-1145–1854.\r\n \r\n What is Known:• It is already known that endurance training has a positive effect on depressive symptoms.\r\n \r\n \r\n What is New:• A relevant proportion of adolescents with major depressive disorder do not achieve their V̇O2max during a graded cardiopulmonary exercise test.• Adolescents with major depressive disorder have significantly lower cardiorespiratory fitness compared to sex- and age-related control values.\r\n \r\n "}],"user_id":"117661","_id":"60095","extern":"1","language":[{"iso":"eng"}],"issue":"1","publication_identifier":{"issn":["1432-1076"]},"publication_status":"published","page":"379-388","intvolume":" 183","citation":{"mla":"Wenzel, Charlotte, et al. “Validation of the Maximal Cardiopulmonary Exercise Test in Adolescents with Major Depressive Disorder and Comparison of Cardiorespiratory Fitness with Sex- and Age-Related Control Values.” European Journal of Pediatrics, vol. 183, no. 1, Springer Science and Business Media LLC, 2023, pp. 379–88, doi:10.1007/s00431-023-05304-6.","short":"C. Wenzel, B.C. Bongers, M.L. Schlagheck, D. Reis, F. Reinhard, P. Schmidt, S. Bernitzki, M. Oberste, H.L. Wunram, P. Zimmer, O. Fricke, European Journal of Pediatrics 183 (2023) 379–388.","bibtex":"@article{Wenzel_Bongers_Schlagheck_Reis_Reinhard_Schmidt_Bernitzki_Oberste_Wunram_Zimmer_et al._2023, title={Validation of the maximal cardiopulmonary exercise test in adolescents with major depressive disorder and comparison of cardiorespiratory fitness with sex- and age-related control values}, volume={183}, DOI={10.1007/s00431-023-05304-6}, number={1}, journal={European Journal of Pediatrics}, publisher={Springer Science and Business Media LLC}, author={Wenzel, Charlotte and Bongers, Bart Chateau and Schlagheck, Marit Lea and Reis, Daniela and Reinhard, Franziska and Schmidt, Peter and Bernitzki, Stefan and Oberste, Max and Wunram, Heidrun Lioba and Zimmer, Philipp and et al.}, year={2023}, pages={379–388} }","apa":"Wenzel, C., Bongers, B. C., Schlagheck, M. L., Reis, D., Reinhard, F., Schmidt, P., Bernitzki, S., Oberste, M., Wunram, H. L., Zimmer, P., & Fricke, O. (2023). Validation of the maximal cardiopulmonary exercise test in adolescents with major depressive disorder and comparison of cardiorespiratory fitness with sex- and age-related control values. European Journal of Pediatrics, 183(1), 379–388. https://doi.org/10.1007/s00431-023-05304-6","ama":"Wenzel C, Bongers BC, Schlagheck ML, et al. Validation of the maximal cardiopulmonary exercise test in adolescents with major depressive disorder and comparison of cardiorespiratory fitness with sex- and age-related control values. European Journal of Pediatrics. 2023;183(1):379-388. doi:10.1007/s00431-023-05304-6","chicago":"Wenzel, Charlotte, Bart Chateau Bongers, Marit Lea Schlagheck, Daniela Reis, Franziska Reinhard, Peter Schmidt, Stefan Bernitzki, et al. “Validation of the Maximal Cardiopulmonary Exercise Test in Adolescents with Major Depressive Disorder and Comparison of Cardiorespiratory Fitness with Sex- and Age-Related Control Values.” European Journal of Pediatrics 183, no. 1 (2023): 379–88. https://doi.org/10.1007/s00431-023-05304-6.","ieee":"C. Wenzel et al., “Validation of the maximal cardiopulmonary exercise test in adolescents with major depressive disorder and comparison of cardiorespiratory fitness with sex- and age-related control values,” European Journal of Pediatrics, vol. 183, no. 1, pp. 379–388, 2023, doi: 10.1007/s00431-023-05304-6."},"year":"2023","volume":183,"date_created":"2025-06-02T09:49:36Z","author":[{"first_name":"Charlotte","last_name":"Wenzel","full_name":"Wenzel, Charlotte"},{"first_name":"Bart Chateau","full_name":"Bongers, Bart Chateau","last_name":"Bongers"},{"orcid":"0000-0002-8913-6080 ","last_name":"Schlagheck","id":"117661","full_name":"Schlagheck, Marit Lea","first_name":"Marit Lea"},{"first_name":"Daniela","last_name":"Reis","full_name":"Reis, Daniela"},{"first_name":"Franziska","full_name":"Reinhard, Franziska","last_name":"Reinhard"},{"full_name":"Schmidt, Peter","last_name":"Schmidt","first_name":"Peter"},{"first_name":"Stefan","full_name":"Bernitzki, Stefan","last_name":"Bernitzki"},{"full_name":"Oberste, Max","last_name":"Oberste","first_name":"Max"},{"first_name":"Heidrun Lioba","last_name":"Wunram","full_name":"Wunram, Heidrun Lioba"},{"first_name":"Philipp","last_name":"Zimmer","full_name":"Zimmer, Philipp"},{"first_name":"Oliver","last_name":"Fricke","full_name":"Fricke, Oliver"}],"publisher":"Springer Science and Business Media LLC","date_updated":"2025-06-02T09:52:44Z","doi":"10.1007/s00431-023-05304-6","title":"Validation of the maximal cardiopulmonary exercise test in adolescents with major depressive disorder and comparison of cardiorespiratory fitness with sex- and age-related control values"},{"publisher":"Wiley","date_updated":"2025-06-02T09:52:02Z","author":[{"first_name":"Florian","full_name":"Javelle, Florian","last_name":"Javelle"},{"orcid":"0000-0002-8913-6080 ","last_name":"Schlagheck","id":"117661","full_name":"Schlagheck, Marit Lea","first_name":"Marit Lea"},{"first_name":"Hannah C.","last_name":"Broos","full_name":"Broos, Hannah C."},{"first_name":"Kiara R.","full_name":"Timpano, Kiara R.","last_name":"Timpano"},{"full_name":"Joormann, Jutta","last_name":"Joormann","first_name":"Jutta"},{"first_name":"Philipp","full_name":"Zimmer, Philipp","last_name":"Zimmer"},{"full_name":"Johnson, Sheri L.","last_name":"Johnson","first_name":"Sheri L."}],"date_created":"2025-06-02T09:50:01Z","volume":80,"title":"On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters","doi":"10.1002/jclp.23608","publication_status":"published","publication_identifier":{"issn":["0021-9762","1097-4679"]},"issue":"2","year":"2023","citation":{"ama":"Javelle F, Schlagheck ML, Broos HC, et al. On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters. Journal of Clinical Psychology. 2023;80(2):339-354. doi:10.1002/jclp.23608","ieee":"F. Javelle et al., “On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters,” Journal of Clinical Psychology, vol. 80, no. 2, pp. 339–354, 2023, doi: 10.1002/jclp.23608.","chicago":"Javelle, Florian, Marit Lea Schlagheck, Hannah C. Broos, Kiara R. Timpano, Jutta Joormann, Philipp Zimmer, and Sheri L. Johnson. “On the Impulsivity Path: Examining the Unique and Conjoint Relations between Emotion‐ and Non‐emotion‐related Impulsivity, Internalizing Symptoms, Alcohol Use, and Physical Health Parameters.” Journal of Clinical Psychology 80, no. 2 (2023): 339–54. https://doi.org/10.1002/jclp.23608.","mla":"Javelle, Florian, et al. “On the Impulsivity Path: Examining the Unique and Conjoint Relations between Emotion‐ and Non‐emotion‐related Impulsivity, Internalizing Symptoms, Alcohol Use, and Physical Health Parameters.” Journal of Clinical Psychology, vol. 80, no. 2, Wiley, 2023, pp. 339–54, doi:10.1002/jclp.23608.","bibtex":"@article{Javelle_Schlagheck_Broos_Timpano_Joormann_Zimmer_Johnson_2023, title={On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters}, volume={80}, DOI={10.1002/jclp.23608}, number={2}, journal={Journal of Clinical Psychology}, publisher={Wiley}, author={Javelle, Florian and Schlagheck, Marit Lea and Broos, Hannah C. and Timpano, Kiara R. and Joormann, Jutta and Zimmer, Philipp and Johnson, Sheri L.}, year={2023}, pages={339–354} }","short":"F. Javelle, M.L. Schlagheck, H.C. Broos, K.R. Timpano, J. Joormann, P. Zimmer, S.L. Johnson, Journal of Clinical Psychology 80 (2023) 339–354.","apa":"Javelle, F., Schlagheck, M. L., Broos, H. C., Timpano, K. R., Joormann, J., Zimmer, P., & Johnson, S. L. (2023). On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters. Journal of Clinical Psychology, 80(2), 339–354. https://doi.org/10.1002/jclp.23608"},"page":"339-354","intvolume":" 80","_id":"60096","user_id":"117661","extern":"1","language":[{"iso":"eng"}],"type":"journal_article","publication":"Journal of Clinical Psychology","abstract":[{"text":"AbstractBackgroundResearchers have increasingly differentiated trait‐like tendencies toward impulsivity occurring during emotional states (emotion‐related impulsivity [ERI]) from impulsivity not tied to emotion (non‐ERI). Relative to non‐ERI, ERI has shown robust correlations with psychopathology and mild to moderate associations with physical health parameters (e.g., physical activity, poor sleep quality, body mass index [BMI]). Therefore, we first aimed to investigate the unique contributions of ERI and non‐ERI to psychopathology symptoms while controlling for neuroticism. Second, we sought to explore the combined associations of physical health parameters with several impulsivity forms.MethodsGerman‐speaking adults (N = 350, 35.9 ± 14.6 years, 69.1% female, BMI: 24.0 ± 4.8 kg/m2, mostly students or employees) completed measures of impulsivity, psychopathology symptoms, neuroticism, and physical health. We gathered measures of two ERI forms: Feelings Trigger Action and Pervasive Influence of Feelings. As a control comparison, we gathered a measure of non‐ERI, the Lack of Follow‐Through scale. We conducted separate path models for Aims 1 and 2.ResultsFor Aim 1, Pervasive Influence of Feelings showed strong links with internalizing symptoms. Feelings Trigger Action and Lack of Follow‐Through showed small links with alcohol use. For Aim 2, poor sleep quality was related to all three impulsivity factors, while physical activity was only related to Pervasive Influence of Feelings and Lack of Follow‐Through. BMI showed a curvilinear association with impulsivity.ConclusionsERI is more directly relevant than non‐ERI for psychopathology symptoms, emphasizing the need to differentiate between the two ERI types. The association of ERI and non‐ERI with physical activity and poor sleep quality may serve as potential treatment targets for impulsivity‐related problems.","lang":"eng"}],"status":"public"},{"language":[{"iso":"eng"}],"publication":"International Journal of Sports Medicine","abstract":[{"lang":"eng","text":"AbstractExercise is described to provoke enhancements of cardiorespiratory fitness in persons with Multiple Sclerosis (pwMS). However, a high inter-individual variability in training responses has been observed. This analysis investigates response heterogeneity in cardiorespiratory fitness following high intensity interval (HIIT) and moderate continuous training (MCT) and analyzes potential predictors of cardiorespiratory training effects in pwMS. 131 pwMS performed HIIT or MCT 3–5x/ week on a cycle ergometer for three weeks. Individual responses were classified. Finally, a multiple linear regression was conducted to examine potential associations between changes of absolute peak oxygen consumption (absolute ∆V̇O2peak/kg), training modality and participant’s characteristics. Results show a time and interaction effect for ∆V̇O2peak/kg. Absolute changes of cardiorespiratory responses were larger and the non-response proportions smaller in HIIT vs. MCT. The model accounting for 8.6% of the variance of ∆V̇O2peak/kg suggests that HIIT, younger age and lower baseline fitness predict a higher absolute ∆V̇O2peak/kg following an exercise intervention. Thus, this work implements a novel approach that investigates potential determinants of cardiorespiratory response heterogeneity within a clinical setting and analyzes a remarkable bigger sample. Further predictors need to be identified to increase the knowledge about response heterogeneity, thereby supporting the development of individualized training recommendations for pwMS."}],"date_created":"2025-05-27T07:54:18Z","publisher":"Georg Thieme Verlag KG","title":"VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?","issue":"14","year":"2021","user_id":"117661","_id":"60044","extern":"1","type":"journal_article","status":"public","volume":42,"author":[{"first_name":"Marit Lea","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","full_name":"Schlagheck, Marit Lea","id":"117661"},{"first_name":"Anika","last_name":"Wucherer","full_name":"Wucherer, Anika"},{"full_name":"Rademacher, Annette","last_name":"Rademacher","first_name":"Annette"},{"first_name":"Niklas","last_name":"Joisten","full_name":"Joisten, Niklas"},{"first_name":"Sebastian","full_name":"Proschinger, Sebastian","last_name":"Proschinger"},{"last_name":"Walzik","full_name":"Walzik, David","first_name":"David"},{"first_name":"Wilhelm","last_name":"Bloch","full_name":"Bloch, Wilhelm"},{"last_name":"Kool","full_name":"Kool, Jan","first_name":"Jan"},{"full_name":"Gonzenbach, Roman","last_name":"Gonzenbach","first_name":"Roman"},{"first_name":"Jens","last_name":"Bansi","full_name":"Bansi, Jens"},{"first_name":"Philipp","full_name":"Zimmer, Philipp","last_name":"Zimmer"}],"date_updated":"2025-06-02T09:33:48Z","doi":"10.1055/a-1481-8639","publication_identifier":{"issn":["0172-4622","1439-3964"]},"publication_status":"published","intvolume":" 42","page":"1319-1328","citation":{"apa":"Schlagheck, M. L., Wucherer, A., Rademacher, A., Joisten, N., Proschinger, S., Walzik, D., Bloch, W., Kool, J., Gonzenbach, R., Bansi, J., & Zimmer, P. (2021). VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT? International Journal of Sports Medicine, 42(14), 1319–1328. https://doi.org/10.1055/a-1481-8639","short":"M.L. Schlagheck, A. Wucherer, A. Rademacher, N. Joisten, S. Proschinger, D. Walzik, W. Bloch, J. Kool, R. Gonzenbach, J. Bansi, P. Zimmer, International Journal of Sports Medicine 42 (2021) 1319–1328.","bibtex":"@article{Schlagheck_Wucherer_Rademacher_Joisten_Proschinger_Walzik_Bloch_Kool_Gonzenbach_Bansi_et al._2021, title={VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?}, volume={42}, DOI={10.1055/a-1481-8639}, number={14}, journal={International Journal of Sports Medicine}, publisher={Georg Thieme Verlag KG}, author={Schlagheck, Marit Lea and Wucherer, Anika and Rademacher, Annette and Joisten, Niklas and Proschinger, Sebastian and Walzik, David and Bloch, Wilhelm and Kool, Jan and Gonzenbach, Roman and Bansi, Jens and et al.}, year={2021}, pages={1319–1328} }","mla":"Schlagheck, Marit Lea, et al. “VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?” International Journal of Sports Medicine, vol. 42, no. 14, Georg Thieme Verlag KG, 2021, pp. 1319–28, doi:10.1055/a-1481-8639.","ama":"Schlagheck ML, Wucherer A, Rademacher A, et al. VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT? International Journal of Sports Medicine. 2021;42(14):1319-1328. doi:10.1055/a-1481-8639","chicago":"Schlagheck, Marit Lea, Anika Wucherer, Annette Rademacher, Niklas Joisten, Sebastian Proschinger, David Walzik, Wilhelm Bloch, et al. “VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?” International Journal of Sports Medicine 42, no. 14 (2021): 1319–28. https://doi.org/10.1055/a-1481-8639.","ieee":"M. L. Schlagheck et al., “VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?,” International Journal of Sports Medicine, vol. 42, no. 14, pp. 1319–1328, 2021, doi: 10.1055/a-1481-8639."}},{"type":"journal_article","publication":"Multiple Sclerosis and Related Disorders","status":"public","_id":"60043","user_id":"117661","article_number":"102905","language":[{"iso":"eng"}],"extern":"1","publication_status":"published","publication_identifier":{"issn":["2211-0348"]},"year":"2021","citation":{"mla":"Rademacher, Annette, et al. “Do Baseline Cognitive Status, Participant Specific Characteristics and EDSS Impact Changes of Cognitive Performance Following Aerobic Exercise Intervention in Multiple Sclerosis?” Multiple Sclerosis and Related Disorders, vol. 51, 102905, Elsevier BV, 2021, doi:10.1016/j.msard.2021.102905.","short":"A. Rademacher, N. Joisten, S. Proschinger, J. Hebchen, M.L. Schlagheck, W. Bloch, R. Gonzenbach, J. Kool, J. Bansi, P. Zimmer, Multiple Sclerosis and Related Disorders 51 (2021).","bibtex":"@article{Rademacher_Joisten_Proschinger_Hebchen_Schlagheck_Bloch_Gonzenbach_Kool_Bansi_Zimmer_2021, title={Do baseline cognitive status, participant specific characteristics and EDSS impact changes of cognitive performance following aerobic exercise intervention in multiple sclerosis?}, volume={51}, DOI={10.1016/j.msard.2021.102905}, number={102905}, journal={Multiple Sclerosis and Related Disorders}, publisher={Elsevier BV}, author={Rademacher, Annette and Joisten, Niklas and Proschinger, Sebastian and Hebchen, Jonas and Schlagheck, Marit Lea and Bloch, Wilhelm and Gonzenbach, Roman and Kool, Jan and Bansi, Jens and Zimmer, Philipp}, year={2021} }","apa":"Rademacher, A., Joisten, N., Proschinger, S., Hebchen, J., Schlagheck, M. L., Bloch, W., Gonzenbach, R., Kool, J., Bansi, J., & Zimmer, P. (2021). Do baseline cognitive status, participant specific characteristics and EDSS impact changes of cognitive performance following aerobic exercise intervention in multiple sclerosis? Multiple Sclerosis and Related Disorders, 51, Article 102905. https://doi.org/10.1016/j.msard.2021.102905","chicago":"Rademacher, Annette, Niklas Joisten, Sebastian Proschinger, Jonas Hebchen, Marit Lea Schlagheck, Wilhelm Bloch, Roman Gonzenbach, Jan Kool, Jens Bansi, and Philipp Zimmer. “Do Baseline Cognitive Status, Participant Specific Characteristics and EDSS Impact Changes of Cognitive Performance Following Aerobic Exercise Intervention in Multiple Sclerosis?” Multiple Sclerosis and Related Disorders 51 (2021). https://doi.org/10.1016/j.msard.2021.102905.","ieee":"A. Rademacher et al., “Do baseline cognitive status, participant specific characteristics and EDSS impact changes of cognitive performance following aerobic exercise intervention in multiple sclerosis?,” Multiple Sclerosis and Related Disorders, vol. 51, Art. no. 102905, 2021, doi: 10.1016/j.msard.2021.102905.","ama":"Rademacher A, Joisten N, Proschinger S, et al. Do baseline cognitive status, participant specific characteristics and EDSS impact changes of cognitive performance following aerobic exercise intervention in multiple sclerosis? Multiple Sclerosis and Related Disorders. 2021;51. doi:10.1016/j.msard.2021.102905"},"intvolume":" 51","publisher":"Elsevier BV","date_updated":"2025-06-02T09:34:33Z","date_created":"2025-05-27T07:54:02Z","author":[{"last_name":"Rademacher","full_name":"Rademacher, Annette","first_name":"Annette"},{"first_name":"Niklas","last_name":"Joisten","full_name":"Joisten, Niklas"},{"full_name":"Proschinger, Sebastian","last_name":"Proschinger","first_name":"Sebastian"},{"full_name":"Hebchen, Jonas","last_name":"Hebchen","first_name":"Jonas"},{"first_name":"Marit Lea","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","id":"117661","full_name":"Schlagheck, Marit Lea"},{"last_name":"Bloch","full_name":"Bloch, Wilhelm","first_name":"Wilhelm"},{"first_name":"Roman","full_name":"Gonzenbach, Roman","last_name":"Gonzenbach"},{"first_name":"Jan","last_name":"Kool","full_name":"Kool, Jan"},{"last_name":"Bansi","full_name":"Bansi, Jens","first_name":"Jens"},{"first_name":"Philipp","full_name":"Zimmer, Philipp","last_name":"Zimmer"}],"volume":51,"title":"Do baseline cognitive status, participant specific characteristics and EDSS impact changes of cognitive performance following aerobic exercise intervention in multiple sclerosis?","doi":"10.1016/j.msard.2021.102905"},{"publication":"Neurology and Therapy","type":"journal_article","status":"public","_id":"60045","user_id":"117661","extern":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2193-8253","2193-6536"]},"publication_status":"published","issue":"2","year":"2021","page":"585-607","intvolume":" 10","citation":{"chicago":"Schlagheck, Marit Lea, Niklas Joisten, David Walzik, Florian Wolf, Sarah E. Neil-Sztramko, Jens Bansi, Annette Rademacher, and Philipp Zimmer. “Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training.” Neurology and Therapy 10, no. 2 (2021): 585–607. https://doi.org/10.1007/s40120-021-00274-z.","ieee":"M. L. Schlagheck et al., “Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training,” Neurology and Therapy, vol. 10, no. 2, pp. 585–607, 2021, doi: 10.1007/s40120-021-00274-z.","ama":"Schlagheck ML, Joisten N, Walzik D, et al. Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training. Neurology and Therapy. 2021;10(2):585-607. doi:10.1007/s40120-021-00274-z","bibtex":"@article{Schlagheck_Joisten_Walzik_Wolf_Neil-Sztramko_Bansi_Rademacher_Zimmer_2021, title={Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training}, volume={10}, DOI={10.1007/s40120-021-00274-z}, number={2}, journal={Neurology and Therapy}, publisher={Springer Science and Business Media LLC}, author={Schlagheck, Marit Lea and Joisten, Niklas and Walzik, David and Wolf, Florian and Neil-Sztramko, Sarah E. and Bansi, Jens and Rademacher, Annette and Zimmer, Philipp}, year={2021}, pages={585–607} }","mla":"Schlagheck, Marit Lea, et al. “Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training.” Neurology and Therapy, vol. 10, no. 2, Springer Science and Business Media LLC, 2021, pp. 585–607, doi:10.1007/s40120-021-00274-z.","short":"M.L. Schlagheck, N. Joisten, D. Walzik, F. Wolf, S.E. Neil-Sztramko, J. Bansi, A. Rademacher, P. Zimmer, Neurology and Therapy 10 (2021) 585–607.","apa":"Schlagheck, M. L., Joisten, N., Walzik, D., Wolf, F., Neil-Sztramko, S. E., Bansi, J., Rademacher, A., & Zimmer, P. (2021). Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training. Neurology and Therapy, 10(2), 585–607. https://doi.org/10.1007/s40120-021-00274-z"},"date_updated":"2025-06-02T09:34:58Z","publisher":"Springer Science and Business Media LLC","volume":10,"author":[{"last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","full_name":"Schlagheck, Marit Lea","id":"117661","first_name":"Marit Lea"},{"first_name":"Niklas","full_name":"Joisten, Niklas","last_name":"Joisten"},{"last_name":"Walzik","full_name":"Walzik, David","first_name":"David"},{"first_name":"Florian","full_name":"Wolf, Florian","last_name":"Wolf"},{"first_name":"Sarah E.","full_name":"Neil-Sztramko, Sarah E.","last_name":"Neil-Sztramko"},{"last_name":"Bansi","full_name":"Bansi, Jens","first_name":"Jens"},{"last_name":"Rademacher","full_name":"Rademacher, Annette","first_name":"Annette"},{"first_name":"Philipp","full_name":"Zimmer, Philipp","last_name":"Zimmer"}],"date_created":"2025-05-27T07:54:31Z","title":"Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training","doi":"10.1007/s40120-021-00274-z"},{"title":"The aerobic capacity – fatigue relationship in persons with Multiple Sclerosis is not reproducible in a pooled analysis of two randomized controlled trials","doi":"10.1016/j.msard.2021.103476","publisher":"Elsevier BV","date_updated":"2025-06-02T09:45:25Z","date_created":"2025-06-02T09:41:32Z","author":[{"first_name":"Florian","last_name":"Wolf","full_name":"Wolf, Florian"},{"first_name":"Annette","last_name":"Rademacher","full_name":"Rademacher, Annette"},{"first_name":"Niklas","full_name":"Joisten, Niklas","last_name":"Joisten"},{"first_name":"Sebastian","last_name":"Proschinger","full_name":"Proschinger, Sebastian"},{"first_name":"Marit Lea","full_name":"Schlagheck, Marit Lea","id":"117661","orcid":"0000-0002-8913-6080 ","last_name":"Schlagheck"},{"last_name":"Bloch","full_name":"Bloch, Wilhelm","first_name":"Wilhelm"},{"last_name":"Gonzenbach","full_name":"Gonzenbach, Roman","first_name":"Roman"},{"first_name":"Jan","full_name":"Kool, Jan","last_name":"Kool"},{"full_name":"Bansi, Jens","last_name":"Bansi","first_name":"Jens"},{"first_name":"Philipp","last_name":"Zimmer","full_name":"Zimmer, Philipp"}],"volume":58,"year":"2021","citation":{"bibtex":"@article{Wolf_Rademacher_Joisten_Proschinger_Schlagheck_Bloch_Gonzenbach_Kool_Bansi_Zimmer_2021, title={The aerobic capacity – fatigue relationship in persons with Multiple Sclerosis is not reproducible in a pooled analysis of two randomized controlled trials}, volume={58}, DOI={10.1016/j.msard.2021.103476}, number={103476}, journal={Multiple Sclerosis and Related Disorders}, publisher={Elsevier BV}, author={Wolf, Florian and Rademacher, Annette and Joisten, Niklas and Proschinger, Sebastian and Schlagheck, Marit Lea and Bloch, Wilhelm and Gonzenbach, Roman and Kool, Jan and Bansi, Jens and Zimmer, Philipp}, year={2021} }","mla":"Wolf, Florian, et al. “The Aerobic Capacity – Fatigue Relationship in Persons with Multiple Sclerosis Is Not Reproducible in a Pooled Analysis of Two Randomized Controlled Trials.” Multiple Sclerosis and Related Disorders, vol. 58, 103476, Elsevier BV, 2021, doi:10.1016/j.msard.2021.103476.","short":"F. Wolf, A. Rademacher, N. Joisten, S. Proschinger, M.L. Schlagheck, W. Bloch, R. Gonzenbach, J. Kool, J. Bansi, P. Zimmer, Multiple Sclerosis and Related Disorders 58 (2021).","apa":"Wolf, F., Rademacher, A., Joisten, N., Proschinger, S., Schlagheck, M. L., Bloch, W., Gonzenbach, R., Kool, J., Bansi, J., & Zimmer, P. (2021). The aerobic capacity – fatigue relationship in persons with Multiple Sclerosis is not reproducible in a pooled analysis of two randomized controlled trials. Multiple Sclerosis and Related Disorders, 58, Article 103476. https://doi.org/10.1016/j.msard.2021.103476","chicago":"Wolf, Florian, Annette Rademacher, Niklas Joisten, Sebastian Proschinger, Marit Lea Schlagheck, Wilhelm Bloch, Roman Gonzenbach, Jan Kool, Jens Bansi, and Philipp Zimmer. “The Aerobic Capacity – Fatigue Relationship in Persons with Multiple Sclerosis Is Not Reproducible in a Pooled Analysis of Two Randomized Controlled Trials.” Multiple Sclerosis and Related Disorders 58 (2021). https://doi.org/10.1016/j.msard.2021.103476.","ieee":"F. Wolf et al., “The aerobic capacity – fatigue relationship in persons with Multiple Sclerosis is not reproducible in a pooled analysis of two randomized controlled trials,” Multiple Sclerosis and Related Disorders, vol. 58, Art. no. 103476, 2021, doi: 10.1016/j.msard.2021.103476.","ama":"Wolf F, Rademacher A, Joisten N, et al. The aerobic capacity – fatigue relationship in persons with Multiple Sclerosis is not reproducible in a pooled analysis of two randomized controlled trials. Multiple Sclerosis and Related Disorders. 2021;58. doi:10.1016/j.msard.2021.103476"},"intvolume":" 58","publication_status":"published","publication_identifier":{"issn":["2211-0348"]},"article_number":"103476","extern":"1","language":[{"iso":"eng"}],"_id":"60090","user_id":"117661","status":"public","type":"journal_article","publication":"Multiple Sclerosis and Related Disorders"},{"publication_identifier":{"issn":["0902-4441","1600-0609"]},"publication_status":"published","intvolume":" 105","page":"75-84","citation":{"ama":"Schlagheck ML, Walzik D, Joisten N, et al. Cellular immune response to acute exercise: Comparison of endurance and resistance exercise. European Journal of Haematology. 2020;105(1):75-84. doi:10.1111/ejh.13412","ieee":"M. L. Schlagheck et al., “Cellular immune response to acute exercise: Comparison of endurance and resistance exercise,” European Journal of Haematology, vol. 105, no. 1, pp. 75–84, 2020, doi: 10.1111/ejh.13412.","chicago":"Schlagheck, Marit Lea, David Walzik, Niklas Joisten, Christina Koliamitra, Luca Hardt, Alan J. Metcalfe, Patrick Wahl, Wilhelm Bloch, Alexander Schenk, and Philipp Zimmer. “Cellular Immune Response to Acute Exercise: Comparison of Endurance and Resistance Exercise.” European Journal of Haematology 105, no. 1 (2020): 75–84. https://doi.org/10.1111/ejh.13412.","apa":"Schlagheck, M. L., Walzik, D., Joisten, N., Koliamitra, C., Hardt, L., Metcalfe, A. J., Wahl, P., Bloch, W., Schenk, A., & Zimmer, P. (2020). Cellular immune response to acute exercise: Comparison of endurance and resistance exercise. European Journal of Haematology, 105(1), 75–84. https://doi.org/10.1111/ejh.13412","short":"M.L. Schlagheck, D. Walzik, N. Joisten, C. Koliamitra, L. Hardt, A.J. Metcalfe, P. Wahl, W. Bloch, A. Schenk, P. Zimmer, European Journal of Haematology 105 (2020) 75–84.","bibtex":"@article{Schlagheck_Walzik_Joisten_Koliamitra_Hardt_Metcalfe_Wahl_Bloch_Schenk_Zimmer_2020, title={Cellular immune response to acute exercise: Comparison of endurance and resistance exercise}, volume={105}, DOI={10.1111/ejh.13412}, number={1}, journal={European Journal of Haematology}, publisher={Wiley}, author={Schlagheck, Marit Lea and Walzik, David and Joisten, Niklas and Koliamitra, Christina and Hardt, Luca and Metcalfe, Alan J. and Wahl, Patrick and Bloch, Wilhelm and Schenk, Alexander and Zimmer, Philipp}, year={2020}, pages={75–84} }","mla":"Schlagheck, Marit Lea, et al. “Cellular Immune Response to Acute Exercise: Comparison of Endurance and Resistance Exercise.” European Journal of Haematology, vol. 105, no. 1, Wiley, 2020, pp. 75–84, doi:10.1111/ejh.13412."},"volume":105,"author":[{"first_name":"Marit Lea","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","full_name":"Schlagheck, Marit Lea","id":"117661"},{"first_name":"David","full_name":"Walzik, David","last_name":"Walzik"},{"last_name":"Joisten","full_name":"Joisten, Niklas","first_name":"Niklas"},{"full_name":"Koliamitra, Christina","last_name":"Koliamitra","first_name":"Christina"},{"full_name":"Hardt, Luca","last_name":"Hardt","first_name":"Luca"},{"last_name":"Metcalfe","full_name":"Metcalfe, Alan J.","first_name":"Alan J."},{"last_name":"Wahl","full_name":"Wahl, Patrick","first_name":"Patrick"},{"full_name":"Bloch, Wilhelm","last_name":"Bloch","first_name":"Wilhelm"},{"last_name":"Schenk","full_name":"Schenk, Alexander","first_name":"Alexander"},{"last_name":"Zimmer","full_name":"Zimmer, Philipp","first_name":"Philipp"}],"date_updated":"2025-06-02T09:34:46Z","doi":"10.1111/ejh.13412","type":"journal_article","status":"public","user_id":"117661","_id":"60042","extern":"1","issue":"1","year":"2020","date_created":"2025-05-27T07:42:01Z","publisher":"Wiley","title":"Cellular immune response to acute exercise: Comparison of endurance and resistance exercise","publication":"European Journal of Haematology","abstract":[{"lang":"eng","text":"AbstractObjectivesExercise‐induced cellular mobilization might play a role in treatment and prevention of several diseases. However, little is known about the impact of different exercise modalities on immune cell mobilization and clinical cellular inflammation markers. Therefore, the present study aimed to investigate differences between acute endurance exercise (EE) and resistance exercise (RE) on cellular immune alterations.MethodsTwenty‐four healthy men conducted an acute EE (cycling at 60% of peak power output) and RE (five exercise machines at 70% of the one‐repetition maximum) session lasting 50 minutes in randomized order. Blood samples were collected before, after and one hour after exercise cessation. Outcomes included counts and proportions of leukocytes, neutrophils (NEUT), lymphocytes (LYM), LYM subsets, CD4/CD8 ratio, and the clinical cellular inflammation markers NEUT/LYM ratio (NLR), platelets/LYM ratio (PLR), and systemic immune inflammation index (SII).ResultsAlterations in all outcomes were revealed except for CD8+T cells, CD4/CD8 ratio, NLR, and PLR. EE induced a stronger cellular immune response and provoked alterations in more immune cell populations than RE. SII was altered only after EE.ConclusionAn acute EE session causes a stronger mobilization of immune cells than RE. Additionally, SII represents an integrative marker to depict immunological alterations."}],"language":[{"iso":"eng"}]},{"user_id":"117661","_id":"60088","language":[{"iso":"eng"}],"extern":"1","article_number":"314","type":"journal_article","publication":"BMC Neurology","status":"public","date_created":"2025-06-02T09:39:20Z","author":[{"last_name":"Proschinger","full_name":"Proschinger, Sebastian","first_name":"Sebastian"},{"full_name":"Joisten, Niklas","last_name":"Joisten","first_name":"Niklas"},{"first_name":"Annette","last_name":"Rademacher","full_name":"Rademacher, Annette"},{"first_name":"Marit Lea","last_name":"Schlagheck","orcid":"0000-0002-8913-6080 ","full_name":"Schlagheck, Marit Lea","id":"117661"},{"full_name":"Walzik, David","last_name":"Walzik","first_name":"David"},{"full_name":"Metcalfe, Alan J.","last_name":"Metcalfe","first_name":"Alan J."},{"full_name":"Oberste, Max","last_name":"Oberste","first_name":"Max"},{"first_name":"Clemens","full_name":"Warnke, Clemens","last_name":"Warnke"},{"first_name":"Wilhelm","last_name":"Bloch","full_name":"Bloch, Wilhelm"},{"full_name":"Schenk, Alexander","last_name":"Schenk","first_name":"Alexander"},{"last_name":"Bansi","full_name":"Bansi, Jens","first_name":"Jens"},{"first_name":"Philipp","last_name":"Zimmer","full_name":"Zimmer, Philipp"}],"volume":19,"publisher":"Springer Science and Business Media LLC","date_updated":"2025-06-02T09:47:30Z","doi":"10.1186/s12883-019-1544-7","title":"Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial","issue":"1","publication_status":"published","publication_identifier":{"issn":["1471-2377"]},"citation":{"mla":"Proschinger, Sebastian, et al. “Influence of Combined Functional Resistance and Endurance Exercise over 12 Weeks on Matrix Metalloproteinase-2 Serum Concentration in Persons with Relapsing-Remitting Multiple Sclerosis – a Community-Based Randomized Controlled Trial.” BMC Neurology, vol. 19, no. 1, 314, Springer Science and Business Media LLC, 2019, doi:10.1186/s12883-019-1544-7.","bibtex":"@article{Proschinger_Joisten_Rademacher_Schlagheck_Walzik_Metcalfe_Oberste_Warnke_Bloch_Schenk_et al._2019, title={Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial}, volume={19}, DOI={10.1186/s12883-019-1544-7}, number={1314}, journal={BMC Neurology}, publisher={Springer Science and Business Media LLC}, author={Proschinger, Sebastian and Joisten, Niklas and Rademacher, Annette and Schlagheck, Marit Lea and Walzik, David and Metcalfe, Alan J. and Oberste, Max and Warnke, Clemens and Bloch, Wilhelm and Schenk, Alexander and et al.}, year={2019} }","short":"S. Proschinger, N. Joisten, A. Rademacher, M.L. Schlagheck, D. Walzik, A.J. Metcalfe, M. Oberste, C. Warnke, W. Bloch, A. Schenk, J. Bansi, P. Zimmer, BMC Neurology 19 (2019).","apa":"Proschinger, S., Joisten, N., Rademacher, A., Schlagheck, M. L., Walzik, D., Metcalfe, A. J., Oberste, M., Warnke, C., Bloch, W., Schenk, A., Bansi, J., & Zimmer, P. (2019). Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial. BMC Neurology, 19(1), Article 314. https://doi.org/10.1186/s12883-019-1544-7","ama":"Proschinger S, Joisten N, Rademacher A, et al. Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial. BMC Neurology. 2019;19(1). doi:10.1186/s12883-019-1544-7","ieee":"S. Proschinger et al., “Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial,” BMC Neurology, vol. 19, no. 1, Art. no. 314, 2019, doi: 10.1186/s12883-019-1544-7.","chicago":"Proschinger, Sebastian, Niklas Joisten, Annette Rademacher, Marit Lea Schlagheck, David Walzik, Alan J. Metcalfe, Max Oberste, et al. “Influence of Combined Functional Resistance and Endurance Exercise over 12 Weeks on Matrix Metalloproteinase-2 Serum Concentration in Persons with Relapsing-Remitting Multiple Sclerosis – a Community-Based Randomized Controlled Trial.” BMC Neurology 19, no. 1 (2019). https://doi.org/10.1186/s12883-019-1544-7."},"intvolume":" 19","year":"2019"}]