[{"issue":"9","quality_controlled":"1","year":"2026","date_created":"2026-03-10T08:23:43Z","publisher":"American Chemical Society (ACS)","title":"Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction","publication":"ACS Omega","abstract":[{"lang":"eng","text":"Continuous flow catalysis utilizing gel-bound organocatalysts within a microfluidic reactor represents a compelling strategy in the realm of organic synthesis. In this study, a quinuclidine-based catalytic monomer (QMA) was synthesized to create polymer gel dots through the process of photopolymerization that serve as a support for the catalyst. The resulting gel-bound organocatalysts were assembled within a continuous microfluidic reactor to facilitate the Baylis–Hillman reaction between various aldehydes and acrylonitrile at a temperature of 50 °C. The conversion of the product was assessed using 1H NMR spectroscopy as an offline analytical method over a duration of 8 h. The findings indicated that highly reactive aldehydes achieved conversion rates exceeding 90%, in contrast to their less reactive counterparts. Furthermore, these results were juxtaposed with previously published data derived from alternative synthetic methodologies, revealing that the continuous microfluidic reactions employing integrated organocatalysts within polymer networks exhibited significantly higher conversions with reduced reaction times (8 h) at the same temperature (50 °C). Additionally, the influence of different geometries (round, triangular, and square) of the gel dots on catalytic activity was investigated, with round and square gel dots demonstrating slightly superior performance compared with triangular gel dots, attributed to their increased surface area. Moreover, an extended reaction period of 6 days was conducted using 4-bromobenzaldehyde and acrylonitrile, resulting in a conversion rate exceeding 70%, which remained stable for 5 days before experiencing a slight decline due to product accumulation on the gel dots."}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2470-1343","2470-1343"]},"publication_status":"published","intvolume":"        11","citation":{"ama":"Killi N, Kumar A, Nebhani L, et al. Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction. <i>ACS Omega</i>. 2026;11(9). doi:<a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>","ieee":"N. Killi <i>et al.</i>, “Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction,” <i>ACS Omega</i>, vol. 11, no. 9, Art. no. 14448, 2026, doi: <a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>.","chicago":"Killi, Naresh, Amit Kumar, Leena Nebhani, Franziska Obst, Andreas Richter, Bernhard Reineke Matsudo, Thomas Zentgraf, and Dirk Kuckling. “Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction.” <i>ACS Omega</i> 11, no. 9 (2026). <a href=\"https://doi.org/10.1021/acsomega.5c09476\">https://doi.org/10.1021/acsomega.5c09476</a>.","apa":"Killi, N., Kumar, A., Nebhani, L., Obst, F., Richter, A., Reineke Matsudo, B., Zentgraf, T., &#38; Kuckling, D. (2026). Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction. <i>ACS Omega</i>, <i>11</i>(9), Article 14448. <a href=\"https://doi.org/10.1021/acsomega.5c09476\">https://doi.org/10.1021/acsomega.5c09476</a>","short":"N. Killi, A. Kumar, L. Nebhani, F. Obst, A. Richter, B. Reineke Matsudo, T. Zentgraf, D. Kuckling, ACS Omega 11 (2026).","bibtex":"@article{Killi_Kumar_Nebhani_Obst_Richter_Reineke Matsudo_Zentgraf_Kuckling_2026, title={Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction}, volume={11}, DOI={<a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>}, number={914448}, journal={ACS Omega}, publisher={American Chemical Society (ACS)}, author={Killi, Naresh and Kumar, Amit and Nebhani, Leena and Obst, Franziska and Richter, Andreas and Reineke Matsudo, Bernhard and Zentgraf, Thomas and Kuckling, Dirk}, year={2026} }","mla":"Killi, Naresh, et al. “Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction.” <i>ACS Omega</i>, vol. 11, no. 9, 14448, American Chemical Society (ACS), 2026, doi:<a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>."},"volume":11,"author":[{"full_name":"Killi, Naresh","last_name":"Killi","first_name":"Naresh"},{"first_name":"Amit","last_name":"Kumar","full_name":"Kumar, Amit"},{"first_name":"Leena","full_name":"Nebhani, Leena","last_name":"Nebhani"},{"last_name":"Obst","full_name":"Obst, Franziska","first_name":"Franziska"},{"last_name":"Richter","full_name":"Richter, Andreas","first_name":"Andreas"},{"first_name":"Bernhard","last_name":"Reineke Matsudo","full_name":"Reineke Matsudo, Bernhard"},{"last_name":"Zentgraf","orcid":"0000-0002-8662-1101","full_name":"Zentgraf, Thomas","id":"30525","first_name":"Thomas"},{"first_name":"Dirk","last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk"}],"oa":"1","date_updated":"2026-03-10T08:27:15Z","doi":"10.1021/acsomega.5c09476","main_file_link":[{"open_access":"1","url":"https://pubs.acs.org/doi/abs/10.1021/acsomega.5c09476"}],"type":"journal_article","status":"public","department":[{"_id":"15"},{"_id":"230"},{"_id":"289"},{"_id":"623"},{"_id":"2"},{"_id":"311"}],"user_id":"30525","_id":"64873","article_number":"14448","article_type":"original"},{"title":"Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst","date_created":"2025-04-11T07:12:02Z","publisher":"MDPI AG","year":"2025","issue":"4","language":[{"iso":"eng"}],"keyword":["flow chemistry","heterogeneous catalysis","sustainable synthesis","organo-catalysis","polymeric gel dots"],"abstract":[{"text":"<jats:p>The use of organo-catalysis in continuous-flow reactor systems is gaining attention in medicinal chemistry due to its cost-effectiveness and reduced chemical waste. In this study, bioactive curcumin (CUM) derivatives were synthesized in a continuously operated microfluidic reactor (MFR), using piperidine-based polymeric networks as catalysts. Piperidine methacrylate and piperidine acrylate were synthesized and subsequently copolymerized with complementary monomers (MMA or DMAA) and crosslinkers (EGDMA or MBAM) via photopolymerization, yielding different polymeric networks. Initially, batch reactions were optimized for the organo-catalytic Knoevenagel condensation between CUM and 4-nitrobenzaldehyde, under various conditions, in the presence of polymer networks. Conversion was assessed using offline 1H NMR spectroscopy, revealing an increase in conversion with enhanced swelling properties of the polymer networks, which facilitated greater accessibility of catalytic sites. In continuous-flow MFR experiments, optimized polymer gel dots exhibited superior catalytic performance, achieving a conversion of up to 72%, compared to other compositions. This improvement was attributed to the enhanced swelling in the reaction mixture (DMSO/methanol, 7:3 v/v) at 40 °C over 72 h. Furthermore, the MFR system enabled the efficient synthesis of a series of CUM derivatives, demonstrating significantly higher conversion rates than traditional batch reactions. Notably, while batch reactions required 90% catalyst loading in the gel, the MFR system achieved a comparable or superior performance with only 50% catalyst, resulting in a higher turnover number. These findings underscore the advantages of continuous-flow organo-catalysis in enhancing catalytic efficiency and sustainability in organic synthesis.</jats:p>","lang":"eng"}],"publication":"Gels","main_file_link":[{"url":"https://www.mdpi.com/2310-2861/11/4/278"}],"doi":"10.3390/gels11040278","author":[{"first_name":"Naresh","full_name":"Killi, Naresh","last_name":"Killi"},{"first_name":"Katja","last_name":"Rumpke","full_name":"Rumpke, Katja"},{"id":"287","full_name":"Kuckling, Dirk","last_name":"Kuckling","first_name":"Dirk"}],"volume":11,"date_updated":"2025-04-11T07:13:26Z","citation":{"apa":"Killi, N., Rumpke, K., &#38; Kuckling, D. (2025). Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst. <i>Gels</i>, <i>11</i>(4), Article 278. <a href=\"https://doi.org/10.3390/gels11040278\">https://doi.org/10.3390/gels11040278</a>","mla":"Killi, Naresh, et al. “Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst.” <i>Gels</i>, vol. 11, no. 4, 278, MDPI AG, 2025, doi:<a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>.","bibtex":"@article{Killi_Rumpke_Kuckling_2025, title={Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst}, volume={11}, DOI={<a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>}, number={4278}, journal={Gels}, publisher={MDPI AG}, author={Killi, Naresh and Rumpke, Katja and Kuckling, Dirk}, year={2025} }","short":"N. Killi, K. Rumpke, D. Kuckling, Gels 11 (2025).","ama":"Killi N, Rumpke K, Kuckling D. Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst. <i>Gels</i>. 2025;11(4). doi:<a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>","ieee":"N. Killi, K. Rumpke, and D. Kuckling, “Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst,” <i>Gels</i>, vol. 11, no. 4, Art. no. 278, 2025, doi: <a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>.","chicago":"Killi, Naresh, Katja Rumpke, and Dirk Kuckling. “Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst.” <i>Gels</i> 11, no. 4 (2025). <a href=\"https://doi.org/10.3390/gels11040278\">https://doi.org/10.3390/gels11040278</a>."},"intvolume":"        11","publication_status":"published","publication_identifier":{"issn":["2310-2861"]},"article_number":"278","user_id":"94","department":[{"_id":"163"}],"_id":"59510","status":"public","type":"journal_article"},{"publication":"Macromolecular Materials and Engineering","type":"journal_article","status":"public","abstract":[{"text":"<jats:title>Abstract</jats:title><jats:p>To minimize or avoid the use of antibiotics, antimicrobial polymers have emerged as a promising option to fight biomaterial‐associated infections, e.g., on titanium‐based implants. However, the challenge is to develop active polymers that exhibit an antimicrobial effect and are compatible with human cells. Different studies aiming for biocidal polymers active in soluble mode, focused on the ratio of cationic to hydrophobic groups, while only marginal knowledge is available for immobilized components. Here a strong hydrophilic electrolyte 4‐vinylbenzyltrimethylammonium chloride (TMA) is chosen as the cationic component. The block composition of the polycationic segment is modified with styrene (Sty) regarding the amphiphilic balance. To adsorb such polymers onto titanium surfaces they are equipped with a polyphosphonic acid anchor block by sequential reversible‐addition‐fragmentation chain‐transfer polymerization (RAFT) polymerization. The polymer composition affected the wetting behavior of adsorbed coatings with water contact angles ranging from 17° to 72°, while zetapotential measurements confirmed high extent of positive charges for all adsorbed polymer coatings. The fundamentally modified block composition resulted in significantly improved cytocompatibility. Antimicrobial efficacy in early bacterial adhesion is still retained from slightly antiadhesive coatings to combined antiadhesive/biocidal activity depending on Sty/TMA ratio in random polymers while a block copolymer revealed lowest antimicrobial effect.</jats:p>","lang":"eng"}],"department":[{"_id":"163"}],"user_id":"94","_id":"59511","language":[{"iso":"eng"}],"keyword":["antiadhesive surfaces","antimicrobial polymers","grafting to","polymerbrushes"],"publication_identifier":{"issn":["1438-7492","1439-2054"]},"publication_status":"published","citation":{"mla":"Wolf‐Brandstetter, Cornelia, et al. “Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.” <i>Macromolecular Materials and Engineering</i>, Wiley, 2025, doi:<a href=\"https://doi.org/10.1002/mame.202500078\">10.1002/mame.202500078</a>.","bibtex":"@article{Wolf‐Brandstetter_Methling_Kuckling_2025, title={Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility}, DOI={<a href=\"https://doi.org/10.1002/mame.202500078\">10.1002/mame.202500078</a>}, journal={Macromolecular Materials and Engineering}, publisher={Wiley}, author={Wolf‐Brandstetter, Cornelia and Methling, Rafael and Kuckling, Dirk}, year={2025} }","short":"C. Wolf‐Brandstetter, R. Methling, D. Kuckling, Macromolecular Materials and Engineering (2025).","apa":"Wolf‐Brandstetter, C., Methling, R., &#38; Kuckling, D. (2025). Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility. <i>Macromolecular Materials and Engineering</i>. <a href=\"https://doi.org/10.1002/mame.202500078\">https://doi.org/10.1002/mame.202500078</a>","ama":"Wolf‐Brandstetter C, Methling R, Kuckling D. Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility. <i>Macromolecular Materials and Engineering</i>. Published online 2025. doi:<a href=\"https://doi.org/10.1002/mame.202500078\">10.1002/mame.202500078</a>","chicago":"Wolf‐Brandstetter, Cornelia, Rafael Methling, and Dirk Kuckling. “Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.” <i>Macromolecular Materials and Engineering</i>, 2025. <a href=\"https://doi.org/10.1002/mame.202500078\">https://doi.org/10.1002/mame.202500078</a>.","ieee":"C. Wolf‐Brandstetter, R. Methling, and D. Kuckling, “Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility,” <i>Macromolecular Materials and Engineering</i>, 2025, doi: <a href=\"https://doi.org/10.1002/mame.202500078\">10.1002/mame.202500078</a>."},"year":"2025","author":[{"full_name":"Wolf‐Brandstetter, Cornelia","last_name":"Wolf‐Brandstetter","first_name":"Cornelia"},{"full_name":"Methling, Rafael","last_name":"Methling","first_name":"Rafael"},{"last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk","first_name":"Dirk"}],"date_created":"2025-04-11T07:35:39Z","publisher":"Wiley","date_updated":"2025-04-11T07:43:06Z","doi":"10.1002/mame.202500078","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500078"}],"title":"Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility"},{"language":[{"iso":"eng"}],"article_number":"126127","article_type":"original","keyword":["Nanoparticles","Drug delivery","Controlled release","Stimuli-responsiveTumor targeting"],"user_id":"94","department":[{"_id":"163"}],"_id":"64884","status":"public","abstract":[{"text":"To address the challenges associated with poor drug solubility and uncontrolled drug release in conventional dosage forms, a combination of polymer design and advanced drug delivery approaches has been employed. The development of pH-responsive nanoparticles for controlled and selective drug release represents a notable advance in adaptive nanomedicine. This study explores the design of a pH-responsive polymer, poly(1,4-phenyleneacetone dimethylene ketal) (PPADK). Additionally, the incorporation of light-responsive ortho-nitrobenzyl groups (o-NB-PPADK) enhanced the degradation upon exposure to light. Based on the polymer, nanoparticles were prepared using the solvent displacement method. The fluorescence dye Lumogen® Red was incorporated as a model substance. The nanoparticles were characterized by dynamic light scattering to determine their hydrodynamic diameter and size distribution, and the surface charge was analyzed. Atomic force microscopy was used to visualize the surface morphology. The nanoparticles remained stable under physiological pH conditions while exhibiting accelerated degradation and substance release in acidic environment, a property potentially exploitable for tumor targeting. Further enhanced degradation and correspondingly increased release was achieved by incorporating light-responsive elements in the polymer structure.\r\nThe cytotoxicity of these newly designed nanoparticles was evaluated in cell culture using a breast cancer cell line. These results support the potential of o-NB-PPADK nanoparticles as a possible candidate for selective and effective cancer therapy, combining stimuli-responsive degradation mechanisms for improved therapeutic outcomes.","lang":"eng"}],"type":"journal_article","publication":"International Journal of Pharmaceutics","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0378517325009640?via%3Dihub"}],"doi":"10.1016/j.ijpharm.2025.126127","title":"Enlightening release strategies: Accelerated nanoparticle degradation and substance release utilizing light- and pH-responsive polymers","author":[{"last_name":"Kramer","full_name":"Kramer, Maurice","first_name":"Maurice"},{"first_name":"Matthias","last_name":"van der Linde","full_name":"van der Linde, Matthias"},{"first_name":"Lisa","last_name":"Hönscheid","full_name":"Hönscheid, Lisa"},{"last_name":"Horky","full_name":"Horky, Corinna","first_name":"Corinna"},{"first_name":"Katharina","last_name":"Völlmecke","full_name":"Völlmecke, Katharina"},{"full_name":"Mulac, Dennis","last_name":"Mulac","first_name":"Dennis"},{"last_name":"Herrmann","full_name":"Herrmann, Fabian","first_name":"Fabian"},{"first_name":"Dirk","last_name":"Kuckling","full_name":"Kuckling, Dirk","id":"287"},{"first_name":"Klaus","last_name":"Langer","full_name":"Langer, Klaus"}],"date_created":"2026-03-11T08:46:17Z","volume":684,"date_updated":"2026-03-11T08:52:22Z","publisher":"Elsevier BV","citation":{"bibtex":"@article{Kramer_van der Linde_Hönscheid_Horky_Völlmecke_Mulac_Herrmann_Kuckling_Langer_2025, title={Enlightening release strategies: Accelerated nanoparticle degradation and substance release utilizing light- and pH-responsive polymers}, volume={684}, DOI={<a href=\"https://doi.org/10.1016/j.ijpharm.2025.126127\">10.1016/j.ijpharm.2025.126127</a>}, number={126127}, journal={International Journal of Pharmaceutics}, publisher={Elsevier BV}, author={Kramer, Maurice and van der Linde, Matthias and Hönscheid, Lisa and Horky, Corinna and Völlmecke, Katharina and Mulac, Dennis and Herrmann, Fabian and Kuckling, Dirk and Langer, Klaus}, year={2025} }","mla":"Kramer, Maurice, et al. “Enlightening Release Strategies: Accelerated Nanoparticle Degradation and Substance Release Utilizing Light- and PH-Responsive Polymers.” <i>International Journal of Pharmaceutics</i>, vol. 684, 126127, Elsevier BV, 2025, doi:<a href=\"https://doi.org/10.1016/j.ijpharm.2025.126127\">10.1016/j.ijpharm.2025.126127</a>.","short":"M. Kramer, M. van der Linde, L. Hönscheid, C. Horky, K. Völlmecke, D. Mulac, F. Herrmann, D. Kuckling, K. Langer, International Journal of Pharmaceutics 684 (2025).","apa":"Kramer, M., van der Linde, M., Hönscheid, L., Horky, C., Völlmecke, K., Mulac, D., Herrmann, F., Kuckling, D., &#38; Langer, K. (2025). Enlightening release strategies: Accelerated nanoparticle degradation and substance release utilizing light- and pH-responsive polymers. <i>International Journal of Pharmaceutics</i>, <i>684</i>, Article 126127. <a href=\"https://doi.org/10.1016/j.ijpharm.2025.126127\">https://doi.org/10.1016/j.ijpharm.2025.126127</a>","ieee":"M. Kramer <i>et al.</i>, “Enlightening release strategies: Accelerated nanoparticle degradation and substance release utilizing light- and pH-responsive polymers,” <i>International Journal of Pharmaceutics</i>, vol. 684, Art. no. 126127, 2025, doi: <a href=\"https://doi.org/10.1016/j.ijpharm.2025.126127\">10.1016/j.ijpharm.2025.126127</a>.","chicago":"Kramer, Maurice, Matthias van der Linde, Lisa Hönscheid, Corinna Horky, Katharina Völlmecke, Dennis Mulac, Fabian Herrmann, Dirk Kuckling, and Klaus Langer. “Enlightening Release Strategies: Accelerated Nanoparticle Degradation and Substance Release Utilizing Light- and PH-Responsive Polymers.” <i>International Journal of Pharmaceutics</i> 684 (2025). <a href=\"https://doi.org/10.1016/j.ijpharm.2025.126127\">https://doi.org/10.1016/j.ijpharm.2025.126127</a>.","ama":"Kramer M, van der Linde M, Hönscheid L, et al. Enlightening release strategies: Accelerated nanoparticle degradation and substance release utilizing light- and pH-responsive polymers. <i>International Journal of Pharmaceutics</i>. 2025;684. doi:<a href=\"https://doi.org/10.1016/j.ijpharm.2025.126127\">10.1016/j.ijpharm.2025.126127</a>"},"intvolume":"       684","year":"2025","publication_status":"published","publication_identifier":{"issn":["0378-5173"]}},{"volume":28,"author":[{"first_name":"Junaid","last_name":"Syed","full_name":"Syed, Junaid"},{"last_name":"Dyck","full_name":"Dyck, Florian","first_name":"Florian"},{"id":"94","full_name":"Herberg, Artjom","last_name":"Herberg","first_name":"Artjom"},{"first_name":"Dirk","full_name":"Kuckling, Dirk","id":"287","last_name":"Kuckling"},{"full_name":"Gosvami, Nitya Nand","last_name":"Gosvami","first_name":"Nitya Nand"}],"date_updated":"2026-03-11T08:56:26Z","doi":"10.1002/adem.202501673","main_file_link":[{"url":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adem.202501673"}],"publication_identifier":{"issn":["1438-1656","1527-2648"]},"publication_status":"published","intvolume":"        28","citation":{"bibtex":"@article{Syed_Dyck_Herberg_Kuckling_Gosvami_2025, title={Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness}, volume={28}, DOI={<a href=\"https://doi.org/10.1002/adem.202501673\">10.1002/adem.202501673</a>}, number={1e202501673}, journal={Advanced Engineering Materials}, publisher={Wiley}, author={Syed, Junaid and Dyck, Florian and Herberg, Artjom and Kuckling, Dirk and Gosvami, Nitya Nand}, year={2025} }","short":"J. Syed, F. Dyck, A. Herberg, D. Kuckling, N.N. Gosvami, Advanced Engineering Materials 28 (2025).","mla":"Syed, Junaid, et al. “Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness.” <i>Advanced Engineering Materials</i>, vol. 28, no. 1, e202501673, Wiley, 2025, doi:<a href=\"https://doi.org/10.1002/adem.202501673\">10.1002/adem.202501673</a>.","apa":"Syed, J., Dyck, F., Herberg, A., Kuckling, D., &#38; Gosvami, N. N. (2025). Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness. <i>Advanced Engineering Materials</i>, <i>28</i>(1), Article e202501673. <a href=\"https://doi.org/10.1002/adem.202501673\">https://doi.org/10.1002/adem.202501673</a>","ieee":"J. Syed, F. Dyck, A. Herberg, D. Kuckling, and N. N. Gosvami, “Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness,” <i>Advanced Engineering Materials</i>, vol. 28, no. 1, Art. no. e202501673, 2025, doi: <a href=\"https://doi.org/10.1002/adem.202501673\">10.1002/adem.202501673</a>.","chicago":"Syed, Junaid, Florian Dyck, Artjom Herberg, Dirk Kuckling, and Nitya Nand Gosvami. “Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness.” <i>Advanced Engineering Materials</i> 28, no. 1 (2025). <a href=\"https://doi.org/10.1002/adem.202501673\">https://doi.org/10.1002/adem.202501673</a>.","ama":"Syed J, Dyck F, Herberg A, Kuckling D, Gosvami NN. Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness. <i>Advanced Engineering Materials</i>. 2025;28(1). doi:<a href=\"https://doi.org/10.1002/adem.202501673\">10.1002/adem.202501673</a>"},"department":[{"_id":"163"}],"user_id":"94","_id":"64885","article_type":"original","article_number":"e202501673","type":"journal_article","status":"public","date_created":"2026-03-11T08:53:17Z","publisher":"Wiley","title":"Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness","issue":"1","year":"2025","language":[{"iso":"eng"}],"publication":"Advanced Engineering Materials","abstract":[{"text":"The tribological behavior of thermo‐responsive poly(N‐isopropylacrylamide) (PNIPAAm)‐based microgels is investigated for use as water‐dispersible lubricant additives. Two types of microgels are synthesized using a surfactant‐free emulsion polymerization method: MG0, consisting of pure PNIPAAm with a volume phase transition temperature (VPTT) of ≈33 °C, and MG16, consisting of PNIPAAm copolymerized with hydrophobic tert‐butyl acrylamide, exhibiting a lower VPTT of around 23 °C. Swelling and lubrication performance are evaluated at 20 and 40 °C. Both microgels significantly reduce friction and wear compared to water alone. At 20 °C, MG0 remains fully swollen and provides effective wear protection through hydrated microgel lubrication. MG16, being near its VPTT, exhibits partial collapse and slightly higher wear. At 40 °C, MG16 demonstrates improved wear resistance, attributed to enhanced film compaction in the collapsed state. Raman spectroscopy and scanning electron microscopy–energy‐dispersive X‐ray spectroscopy confirm that carbon‐rich tribofilms are formed via tribochemical reactions. MG0 produces more graphitic films, while MG16 generates amorphous carbon structures. These findings highlight the tunability of microgel composition for designing adaptive, water‐based lubricants for temperature‐sensitive applications.","lang":"eng"}]},{"publication":"European Journal of Organic Chemistry","type":"journal_article","abstract":[{"text":"<jats:title>Abstract</jats:title><jats:p>We conducted an investigation into the palladium‐catalyzed carbon‐sulfur cross‐coupling reaction involving a 2‐bromothiophene derivative and potassium thioacetate as a substitute for hydrogen sulfide. This investigation utilized kinetic and computational methods. We synthesized two palladium complexes supported by the bisphosphane ligands bis(diphenylphosphino)ferrocene (DPPF) and bis(diisopropylphosphino)ferrocene (D<jats:italic>i</jats:italic>PPF), as well as their tentative intermediates in the catalytic cycle. Reaction rates were measured and then compared to computational predictions.</jats:p>","lang":"eng"}],"status":"public","_id":"52541","department":[{"_id":"2"},{"_id":"389"}],"user_id":"53339","keyword":["Organic Chemistry","Physical and Theoretical Chemistry"],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1434-193X","1099-0690"]},"publication_status":"published","issue":"8","year":"2024","intvolume":"        27","citation":{"ama":"Peschtrich S, Schoch R, Kuckling D, Paradies J. A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes. <i>European Journal of Organic Chemistry</i>. 2024;27(8). doi:<a href=\"https://doi.org/10.1002/ejoc.202301207\">10.1002/ejoc.202301207</a>","chicago":"Peschtrich, Sebastian, Roland Schoch, Dirk Kuckling, and Jan Paradies. “A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes.” <i>European Journal of Organic Chemistry</i> 27, no. 8 (2024). <a href=\"https://doi.org/10.1002/ejoc.202301207\">https://doi.org/10.1002/ejoc.202301207</a>.","ieee":"S. Peschtrich, R. Schoch, D. Kuckling, and J. Paradies, “A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes,” <i>European Journal of Organic Chemistry</i>, vol. 27, no. 8, 2024, doi: <a href=\"https://doi.org/10.1002/ejoc.202301207\">10.1002/ejoc.202301207</a>.","apa":"Peschtrich, S., Schoch, R., Kuckling, D., &#38; Paradies, J. (2024). A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes. <i>European Journal of Organic Chemistry</i>, <i>27</i>(8). <a href=\"https://doi.org/10.1002/ejoc.202301207\">https://doi.org/10.1002/ejoc.202301207</a>","mla":"Peschtrich, Sebastian, et al. “A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes.” <i>European Journal of Organic Chemistry</i>, vol. 27, no. 8, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/ejoc.202301207\">10.1002/ejoc.202301207</a>.","short":"S. Peschtrich, R. Schoch, D. Kuckling, J. Paradies, European Journal of Organic Chemistry 27 (2024).","bibtex":"@article{Peschtrich_Schoch_Kuckling_Paradies_2024, title={A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes}, volume={27}, DOI={<a href=\"https://doi.org/10.1002/ejoc.202301207\">10.1002/ejoc.202301207</a>}, number={8}, journal={European Journal of Organic Chemistry}, publisher={Wiley}, author={Peschtrich, Sebastian and Schoch, Roland and Kuckling, Dirk and Paradies, Jan}, year={2024} }"},"publisher":"Wiley","date_updated":"2024-03-13T17:17:37Z","volume":27,"author":[{"first_name":"Sebastian","full_name":"Peschtrich, Sebastian","last_name":"Peschtrich"},{"first_name":"Roland","id":"48467","full_name":"Schoch, Roland","last_name":"Schoch","orcid":"0000-0003-2061-7289"},{"first_name":"Dirk","last_name":"Kuckling","full_name":"Kuckling, Dirk","id":"287"},{"first_name":"Jan","orcid":"0000-0002-3698-668X","last_name":"Paradies","full_name":"Paradies, Jan","id":"53339"}],"date_created":"2024-03-13T17:15:14Z","title":"A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes","doi":"10.1002/ejoc.202301207"},{"keyword":["Organic Chemistry","Polymers and Plastics","Biochemistry","Bioengineering"],"language":[{"iso":"eng"}],"publication":"Polymer Chemistry","abstract":[{"text":"<jats:p>An SPR-based dually crosslinked gel sensor for adiponitrile bearing pillar[5]arene responsive sites with a low limit of detection was developed.</jats:p>","lang":"eng"}],"publisher":"Royal Society of Chemistry (RSC)","date_created":"2024-04-03T10:57:17Z","title":"Pillar[5]arene-based dually crosslinked supramolecular gel as a sensor for the detection of adiponitrile","issue":"7","year":"2024","_id":"53163","department":[{"_id":"163"}],"user_id":"94","article_type":"original","type":"journal_article","status":"public","date_updated":"2024-04-03T11:03:03Z","volume":15,"author":[{"full_name":"Rodin, Maksim","last_name":"Rodin","first_name":"Maksim"},{"last_name":"Helle","full_name":"Helle, David","first_name":"David"},{"first_name":"Dirk","id":"287","full_name":"Kuckling, Dirk","last_name":"Kuckling"}],"doi":"10.1039/d3py01354e","publication_identifier":{"issn":["1759-9954","1759-9962"]},"publication_status":"published","intvolume":"        15","page":"661-679","citation":{"ieee":"M. Rodin, D. Helle, and D. Kuckling, “Pillar[5]arene-based dually crosslinked supramolecular gel as a sensor for the detection of adiponitrile,” <i>Polymer Chemistry</i>, vol. 15, no. 7, pp. 661–679, 2024, doi: <a href=\"https://doi.org/10.1039/d3py01354e\">10.1039/d3py01354e</a>.","chicago":"Rodin, Maksim, David Helle, and Dirk Kuckling. “Pillar[5]Arene-Based Dually Crosslinked Supramolecular Gel as a Sensor for the Detection of Adiponitrile.” <i>Polymer Chemistry</i> 15, no. 7 (2024): 661–79. <a href=\"https://doi.org/10.1039/d3py01354e\">https://doi.org/10.1039/d3py01354e</a>.","ama":"Rodin M, Helle D, Kuckling D. Pillar[5]arene-based dually crosslinked supramolecular gel as a sensor for the detection of adiponitrile. <i>Polymer Chemistry</i>. 2024;15(7):661-679. doi:<a href=\"https://doi.org/10.1039/d3py01354e\">10.1039/d3py01354e</a>","bibtex":"@article{Rodin_Helle_Kuckling_2024, title={Pillar[5]arene-based dually crosslinked supramolecular gel as a sensor for the detection of adiponitrile}, volume={15}, DOI={<a href=\"https://doi.org/10.1039/d3py01354e\">10.1039/d3py01354e</a>}, number={7}, journal={Polymer Chemistry}, publisher={Royal Society of Chemistry (RSC)}, author={Rodin, Maksim and Helle, David and Kuckling, Dirk}, year={2024}, pages={661–679} }","mla":"Rodin, Maksim, et al. “Pillar[5]Arene-Based Dually Crosslinked Supramolecular Gel as a Sensor for the Detection of Adiponitrile.” <i>Polymer Chemistry</i>, vol. 15, no. 7, Royal Society of Chemistry (RSC), 2024, pp. 661–79, doi:<a href=\"https://doi.org/10.1039/d3py01354e\">10.1039/d3py01354e</a>.","short":"M. Rodin, D. Helle, D. Kuckling, Polymer Chemistry 15 (2024) 661–679.","apa":"Rodin, M., Helle, D., &#38; Kuckling, D. (2024). Pillar[5]arene-based dually crosslinked supramolecular gel as a sensor for the detection of adiponitrile. <i>Polymer Chemistry</i>, <i>15</i>(7), 661–679. <a href=\"https://doi.org/10.1039/d3py01354e\">https://doi.org/10.1039/d3py01354e</a>"}},{"date_updated":"2025-04-11T07:09:03Z","author":[{"first_name":"Rafael","last_name":"Methling","full_name":"Methling, Rafael"},{"first_name":"Michael","last_name":"Greiter","full_name":"Greiter, Michael"},{"first_name":"Jiwar","full_name":"Al‐Zawity, Jiwar","last_name":"Al‐Zawity"},{"first_name":"Mareike","full_name":"Müller, Mareike","last_name":"Müller"},{"first_name":"Holger","last_name":"Schönherr","full_name":"Schönherr, Holger"},{"full_name":"Kuckling, Dirk","id":"287","last_name":"Kuckling","first_name":"Dirk"}],"volume":25,"main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400261"}],"doi":"10.1002/mabi.202400261","publication_status":"published","publication_identifier":{"issn":["1616-5187","1616-5195"]},"citation":{"apa":"Methling, R., Greiter, M., Al‐Zawity, J., Müller, M., Schönherr, H., &#38; Kuckling, D. (2024). Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties. <i>Macromolecular Bioscience</i>, <i>25</i>(1). <a href=\"https://doi.org/10.1002/mabi.202400261\">https://doi.org/10.1002/mabi.202400261</a>","short":"R. Methling, M. Greiter, J. Al‐Zawity, M. Müller, H. Schönherr, D. Kuckling, Macromolecular Bioscience 25 (2024).","mla":"Methling, Rafael, et al. “Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.” <i>Macromolecular Bioscience</i>, vol. 25, no. 1, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/mabi.202400261\">10.1002/mabi.202400261</a>.","bibtex":"@article{Methling_Greiter_Al‐Zawity_Müller_Schönherr_Kuckling_2024, title={Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties}, volume={25}, DOI={<a href=\"https://doi.org/10.1002/mabi.202400261\">10.1002/mabi.202400261</a>}, number={1}, journal={Macromolecular Bioscience}, publisher={Wiley}, author={Methling, Rafael and Greiter, Michael and Al‐Zawity, Jiwar and Müller, Mareike and Schönherr, Holger and Kuckling, Dirk}, year={2024} }","chicago":"Methling, Rafael, Michael Greiter, Jiwar Al‐Zawity, Mareike Müller, Holger Schönherr, and Dirk Kuckling. “Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.” <i>Macromolecular Bioscience</i> 25, no. 1 (2024). <a href=\"https://doi.org/10.1002/mabi.202400261\">https://doi.org/10.1002/mabi.202400261</a>.","ieee":"R. Methling, M. Greiter, J. Al‐Zawity, M. Müller, H. Schönherr, and D. Kuckling, “Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties,” <i>Macromolecular Bioscience</i>, vol. 25, no. 1, 2024, doi: <a href=\"https://doi.org/10.1002/mabi.202400261\">10.1002/mabi.202400261</a>.","ama":"Methling R, Greiter M, Al‐Zawity J, Müller M, Schönherr H, Kuckling D. Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties. <i>Macromolecular Bioscience</i>. 2024;25(1). doi:<a href=\"https://doi.org/10.1002/mabi.202400261\">10.1002/mabi.202400261</a>"},"intvolume":"        25","_id":"59509","user_id":"94","department":[{"_id":"163"}],"type":"journal_article","status":"public","publisher":"Wiley","date_created":"2025-04-11T07:07:31Z","title":"Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties","issue":"1","year":"2024","keyword":["antibacterial coatings","antipolyelectrolyte effect","salt switchable polymers","zwitterionic brushes"],"language":[{"iso":"eng"}],"publication":"Macromolecular Bioscience","abstract":[{"text":"<jats:title>Abstract</jats:title><jats:p>A strategy for multifunctional biosurfaces exploiting multiblock copolymers and the antipolyelectrolyte effect is reported. Combining a polyzwitterionic/antifouling and a polycationic/antibacterial block with a central anchoring block for attachment to titanium oxide surfaces affords surface coatings that exhibit antifouling properties against proteins and allow for surface regeneration by clearing adhering proteins by employing a salt washing step. The surfaces also kill bacteria by contact killing, which is aided by a nonfouling block. The synthesis of block copolymers of 4‐vinyl pyridine (VP), dimethyl 4‐vinylbenzyl phosphonate (DMVBP), and 4‐vinylbenzyltrimethyl ammonium chloride (TMA) is achieved on the multigram scale via RAFT polymerization with good end group retention and narrow dispersities. By polymer analogous reactions, poly(4‐vinyl pyridinium propane sulfonate‐<jats:italic>block</jats:italic>‐4‐vinylbenzyl phosphonic acid‐<jats:italic>block</jats:italic>‐4‐vinylbenzyl trimethylammonium chloride) (P(VSP<jats:sub>64</jats:sub>‐<jats:italic>b</jats:italic>‐PA<jats:sub>14</jats:sub>‐<jats:italic>b</jats:italic>‐TMA<jats:sub>64</jats:sub>)) is obtained. The antifouling properties against the model protein pepsin and the salt‐induced surface regeneration are shown in surface plasmon resonance (SPR) experiments, while independently the antibacterial and antifouling properties of coated titanium substrates are successfully tested in preliminary microbiological assays against <jats:italic>Staphylococcus aureus</jats:italic> (<jats:italic>S. aureus</jats:italic>) and <jats:italic>Escherichia coli</jats:italic> (<jats:italic>E. coli</jats:italic>). This strategy may contribute to the development of long‐term effective antibacterial implant surface coatings to suppress biomedical device‐associated infections.</jats:p>","lang":"eng"}]},{"volume":14,"author":[{"full_name":"Völlmecke, Katharina","last_name":"Völlmecke","first_name":"Katharina"},{"full_name":"Kramer, Maurice","last_name":"Kramer","first_name":"Maurice"},{"first_name":"Corinna","full_name":"Horky, Corinna","last_name":"Horky"},{"full_name":"Dückmann, Oliver","last_name":"Dückmann","first_name":"Oliver"},{"first_name":"Dennis","full_name":"Mulac, Dennis","last_name":"Mulac"},{"first_name":"Klaus","last_name":"Langer","full_name":"Langer, Klaus"},{"id":"287","full_name":"Kuckling, Dirk","last_name":"Kuckling","first_name":"Dirk"}],"date_updated":"2025-04-11T07:06:22Z","doi":"10.1039/d4ra07228f","main_file_link":[{"url":"https://pubs.rsc.org/en/content/articlelanding/2024/ra/d4ra07228f"}],"publication_identifier":{"issn":["2046-2069"]},"publication_status":"published","intvolume":"        14","page":"35568-35577","citation":{"apa":"Völlmecke, K., Kramer, M., Horky, C., Dückmann, O., Mulac, D., Langer, K., &#38; Kuckling, D. (2024). Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems. <i>RSC Advances</i>, <i>14</i>(48), 35568–35577. <a href=\"https://doi.org/10.1039/d4ra07228f\">https://doi.org/10.1039/d4ra07228f</a>","mla":"Völlmecke, Katharina, et al. “Self-Immolative Polydisulfides and Their Use as Nanoparticles for Drug Delivery Systems.” <i>RSC Advances</i>, vol. 14, no. 48, Royal Society of Chemistry (RSC), 2024, pp. 35568–77, doi:<a href=\"https://doi.org/10.1039/d4ra07228f\">10.1039/d4ra07228f</a>.","bibtex":"@article{Völlmecke_Kramer_Horky_Dückmann_Mulac_Langer_Kuckling_2024, title={Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems}, volume={14}, DOI={<a href=\"https://doi.org/10.1039/d4ra07228f\">10.1039/d4ra07228f</a>}, number={48}, journal={RSC Advances}, publisher={Royal Society of Chemistry (RSC)}, author={Völlmecke, Katharina and Kramer, Maurice and Horky, Corinna and Dückmann, Oliver and Mulac, Dennis and Langer, Klaus and Kuckling, Dirk}, year={2024}, pages={35568–35577} }","short":"K. Völlmecke, M. Kramer, C. Horky, O. Dückmann, D. Mulac, K. Langer, D. Kuckling, RSC Advances 14 (2024) 35568–35577.","ama":"Völlmecke K, Kramer M, Horky C, et al. Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems. <i>RSC Advances</i>. 2024;14(48):35568-35577. doi:<a href=\"https://doi.org/10.1039/d4ra07228f\">10.1039/d4ra07228f</a>","ieee":"K. Völlmecke <i>et al.</i>, “Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems,” <i>RSC Advances</i>, vol. 14, no. 48, pp. 35568–35577, 2024, doi: <a href=\"https://doi.org/10.1039/d4ra07228f\">10.1039/d4ra07228f</a>.","chicago":"Völlmecke, Katharina, Maurice Kramer, Corinna Horky, Oliver Dückmann, Dennis Mulac, Klaus Langer, and Dirk Kuckling. “Self-Immolative Polydisulfides and Their Use as Nanoparticles for Drug Delivery Systems.” <i>RSC Advances</i> 14, no. 48 (2024): 35568–77. <a href=\"https://doi.org/10.1039/d4ra07228f\">https://doi.org/10.1039/d4ra07228f</a>."},"department":[{"_id":"163"}],"user_id":"94","_id":"59508","article_type":"original","type":"journal_article","status":"public","date_created":"2025-04-11T07:03:03Z","publisher":"Royal Society of Chemistry (RSC)","title":"Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems","issue":"48","year":"2024","language":[{"iso":"eng"}],"publication":"RSC Advances","abstract":[{"text":"Over the last few decades, nanotechnology has established to be a promising field in medicine. A remaining dominant challenge in today's pharmacotherapy is the limited selectivity of active pharmaceutical ingredients and associated undesirable side effects. Controlled drug release can be promoted by smart drug delivery systems, which release embedded API primarily depending on specific stimuli. Consequently, also the microenvironment of tumor tissue can be used advantageously. Dithiothreitol (DTT) based self-immolative polydisulfides were synthesized that preferentially respond to pathologically increased glutathione (GSH) concentrations, as found in solid tumors. The synthesis with different degrees of polymerisation was investigated as well as the synthesis of a copolymer consisting of dithiothreitol and butanedithiol (BDT). Toxicity tests were carried out on pure polymers and their degradation products. The ability to degrade was examined at pathological and physiological glutathione concentrations in order to test the suitability of the polymer as a matrix for nanoparticulate carrier systems. In addition, the processability of one polymer into nanoparticles was investigated as well as the degradation behaviour with glutathione.","lang":"eng"}]},{"citation":{"ama":"Rust T, Jung D, Langer K, Kuckling D. Stimuli‐accelerated polymeric drug delivery systems. <i>Polymer International</i>. 2023;72(1):5-19. doi:<a href=\"https://doi.org/10.1002/pi.6474\">10.1002/pi.6474</a>","chicago":"Rust, Tarik, Dimitri Jung, Klaus Langer, and Dirk Kuckling. “Stimuli‐accelerated Polymeric Drug Delivery Systems.” <i>Polymer International</i> 72, no. 1 (2023): 5–19. <a href=\"https://doi.org/10.1002/pi.6474\">https://doi.org/10.1002/pi.6474</a>.","ieee":"T. Rust, D. Jung, K. Langer, and D. Kuckling, “Stimuli‐accelerated polymeric drug delivery systems,” <i>Polymer International</i>, vol. 72, no. 1, pp. 5–19, 2023, doi: <a href=\"https://doi.org/10.1002/pi.6474\">10.1002/pi.6474</a>.","apa":"Rust, T., Jung, D., Langer, K., &#38; Kuckling, D. (2023). Stimuli‐accelerated polymeric drug delivery systems. <i>Polymer International</i>, <i>72</i>(1), 5–19. <a href=\"https://doi.org/10.1002/pi.6474\">https://doi.org/10.1002/pi.6474</a>","mla":"Rust, Tarik, et al. “Stimuli‐accelerated Polymeric Drug Delivery Systems.” <i>Polymer International</i>, vol. 72, no. 1, Wiley, 2023, pp. 5–19, doi:<a href=\"https://doi.org/10.1002/pi.6474\">10.1002/pi.6474</a>.","bibtex":"@article{Rust_Jung_Langer_Kuckling_2023, title={Stimuli‐accelerated polymeric drug delivery systems}, volume={72}, DOI={<a href=\"https://doi.org/10.1002/pi.6474\">10.1002/pi.6474</a>}, number={1}, journal={Polymer International}, publisher={Wiley}, author={Rust, Tarik and Jung, Dimitri and Langer, Klaus and Kuckling, Dirk}, year={2023}, pages={5–19} }","short":"T. Rust, D. Jung, K. Langer, D. Kuckling, Polymer International 72 (2023) 5–19."},"page":"5-19","intvolume":"        72","publication_status":"published","publication_identifier":{"issn":["0959-8103","1097-0126"]},"main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/pi.6474"}],"doi":"10.1002/pi.6474","date_updated":"2023-01-10T08:31:31Z","author":[{"first_name":"Tarik","last_name":"Rust","full_name":"Rust, Tarik"},{"first_name":"Dimitri","full_name":"Jung, Dimitri","last_name":"Jung"},{"first_name":"Klaus","full_name":"Langer, Klaus","last_name":"Langer"},{"first_name":"Dirk","last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk"}],"volume":72,"status":"public","type":"journal_article","article_type":"original","_id":"35657","user_id":"94","department":[{"_id":"163"}],"year":"2023","issue":"1","title":"Stimuli‐accelerated polymeric drug delivery systems","publisher":"Wiley","date_created":"2023-01-10T08:25:22Z","abstract":[{"text":"The controlled delivery of active pharmaceutical ingredients to the site of disease represents a major challenge in drug therapy. Particularly when drugs have to be transported across biological barriers, suitable drug delivery systems are of importance. In recent years responsive delivery systems have been developed which enable a controlled drug release depending on internal or external stimuli such as changes in pH, redox environment or light and temperature. In some studies delivery systems with reactivity against two different stimuli were established either to enhance the response by synergies of the stimuli or to broaden the window of possible trigger events. In the present review numerous exciting developments of pH-, light- and redox-cleavable polymers suitable for the preparation of smart delivery systems are described. The review discusses the different stimuli that can be used for a controlled drug release of polymer-based delivery systems. It puts a focus on the different polymers described for the preparation of stimuli-sensitive systems, their preparation techniques as well as their stimuli-responsive degradation. © 2022 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.","lang":"eng"}],"publication":"Polymer International","keyword":["drug delivery system","stimuli","polymer","cleavable"],"language":[{"iso":"eng"}]},{"issue":"8","year":"2023","publisher":"Wiley","date_created":"2024-04-03T11:08:51Z","title":"Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers","publication":"Macromolecular Materials and Engineering","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:p>Coating medical implants with antibacterial polymers may prevent postoperative infections which are a common issue for conventional titanium implants and can even lead to implant failure. Easily applicable diblock copolymers are presented that form polymer brushes via “grafting to” mechanism on titanium and equip the modified material with antibacterial properties. The polymers carry quaternized pyridinium units to combat bacteria and phosphonic acid groups which allow the linear chains to be anchored to metal surfaces in a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy and SEC. Low grafting densities are a major drawback of the “grafting to” approach compared to “grafting from”. Thus, the number of phosphonic acid groups in the anchor block are varied to investigate and optimize the surface binding. Modified titanium surfaces are examined regarding their composition, wetting behavior, streaming potential, and coating stability. Evaluation of the antimicrobial properties revealed reduced bacterial adhesion and biofilm formation for certain polymers, albeit the cell biocompatibility against human gingival fibroblasts is also impaired. The presented findings show the potential of easy‐to‐apply polymer coatings and aid in designing next‐generation implant surface modifications.</jats:p>"}],"keyword":["Materials Chemistry","Polymers and Plastics","Organic Chemistry","General Chemical Engineering"],"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["1438-7492","1439-2054"]},"citation":{"apa":"Methling, R., Dückmann, O., Simon, F., Wolf‐Brandstetter, C., &#38; Kuckling, D. (2023). Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers. <i>Macromolecular Materials and Engineering</i>, <i>308</i>(8). <a href=\"https://doi.org/10.1002/mame.202200665\">https://doi.org/10.1002/mame.202200665</a>","mla":"Methling, Rafael, et al. “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using Phosphonic Acid/Pyridinium Containing Block Copolymers.” <i>Macromolecular Materials and Engineering</i>, vol. 308, no. 8, Wiley, 2023, doi:<a href=\"https://doi.org/10.1002/mame.202200665\">10.1002/mame.202200665</a>.","short":"R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, D. Kuckling, Macromolecular Materials and Engineering 308 (2023).","bibtex":"@article{Methling_Dückmann_Simon_Wolf‐Brandstetter_Kuckling_2023, title={Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers}, volume={308}, DOI={<a href=\"https://doi.org/10.1002/mame.202200665\">10.1002/mame.202200665</a>}, number={8}, journal={Macromolecular Materials and Engineering}, publisher={Wiley}, author={Methling, Rafael and Dückmann, Oliver and Simon, Frank and Wolf‐Brandstetter, Cornelia and Kuckling, Dirk}, year={2023} }","ama":"Methling R, Dückmann O, Simon F, Wolf‐Brandstetter C, Kuckling D. Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers. <i>Macromolecular Materials and Engineering</i>. 2023;308(8). doi:<a href=\"https://doi.org/10.1002/mame.202200665\">10.1002/mame.202200665</a>","ieee":"R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, and D. Kuckling, “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using Phosphonic Acid/Pyridinium Containing Block Copolymers,” <i>Macromolecular Materials and Engineering</i>, vol. 308, no. 8, 2023, doi: <a href=\"https://doi.org/10.1002/mame.202200665\">10.1002/mame.202200665</a>.","chicago":"Methling, Rafael, Oliver Dückmann, Frank Simon, Cornelia Wolf‐Brandstetter, and Dirk Kuckling. “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using Phosphonic Acid/Pyridinium Containing Block Copolymers.” <i>Macromolecular Materials and Engineering</i> 308, no. 8 (2023). <a href=\"https://doi.org/10.1002/mame.202200665\">https://doi.org/10.1002/mame.202200665</a>."},"intvolume":"       308","date_updated":"2024-04-03T11:10:05Z","author":[{"full_name":"Methling, Rafael","last_name":"Methling","first_name":"Rafael"},{"full_name":"Dückmann, Oliver","last_name":"Dückmann","first_name":"Oliver"},{"full_name":"Simon, Frank","last_name":"Simon","first_name":"Frank"},{"last_name":"Wolf‐Brandstetter","full_name":"Wolf‐Brandstetter, Cornelia","first_name":"Cornelia"},{"first_name":"Dirk","last_name":"Kuckling","full_name":"Kuckling, Dirk","id":"287"}],"volume":308,"doi":"10.1002/mame.202200665","type":"journal_article","status":"public","_id":"53170","user_id":"94","department":[{"_id":"163"}],"article_type":"original"},{"publication_identifier":{"issn":["2310-2861"]},"publication_status":"published","intvolume":"         9","citation":{"mla":"Killi, Naresh, et al. “Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors.” <i>Gels</i>, vol. 9, no. 3, 171, MDPI AG, 2023, doi:<a href=\"https://doi.org/10.3390/gels9030171\">10.3390/gels9030171</a>.","short":"N. Killi, J. Bartenbach, D. Kuckling, Gels 9 (2023).","bibtex":"@article{Killi_Bartenbach_Kuckling_2023, title={Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors}, volume={9}, DOI={<a href=\"https://doi.org/10.3390/gels9030171\">10.3390/gels9030171</a>}, number={3171}, journal={Gels}, publisher={MDPI AG}, author={Killi, Naresh and Bartenbach, Julian and Kuckling, Dirk}, year={2023} }","apa":"Killi, N., Bartenbach, J., &#38; Kuckling, D. (2023). Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors. <i>Gels</i>, <i>9</i>(3), Article 171. <a href=\"https://doi.org/10.3390/gels9030171\">https://doi.org/10.3390/gels9030171</a>","ama":"Killi N, Bartenbach J, Kuckling D. Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors. <i>Gels</i>. 2023;9(3). doi:<a href=\"https://doi.org/10.3390/gels9030171\">10.3390/gels9030171</a>","ieee":"N. Killi, J. Bartenbach, and D. Kuckling, “Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors,” <i>Gels</i>, vol. 9, no. 3, Art. no. 171, 2023, doi: <a href=\"https://doi.org/10.3390/gels9030171\">10.3390/gels9030171</a>.","chicago":"Killi, Naresh, Julian Bartenbach, and Dirk Kuckling. “Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors.” <i>Gels</i> 9, no. 3 (2023). <a href=\"https://doi.org/10.3390/gels9030171\">https://doi.org/10.3390/gels9030171</a>."},"date_updated":"2024-04-03T11:07:31Z","volume":9,"author":[{"full_name":"Killi, Naresh","last_name":"Killi","first_name":"Naresh"},{"first_name":"Julian","last_name":"Bartenbach","full_name":"Bartenbach, Julian"},{"full_name":"Kuckling, Dirk","id":"287","last_name":"Kuckling","first_name":"Dirk"}],"doi":"10.3390/gels9030171","type":"journal_article","status":"public","_id":"53166","department":[{"_id":"163"}],"user_id":"94","article_number":"171","article_type":"original","issue":"3","year":"2023","publisher":"MDPI AG","date_created":"2024-04-03T11:06:26Z","title":"Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors","publication":"Gels","abstract":[{"text":"<jats:p>The Knoevenagel reaction is a classic reaction in organic chemistry for the formation of C-C bonds. In this study, various catalytic monomers for Knoevenagel reactions were synthesized and polymerized via photolithography to form polymeric gel dots with a composition of 90% catalyst, 9% gelling agent and 1% crosslinker. Furthermore, these gel dots were inserted into a microfluidic reactor (MFR) and the conversion of the reaction using gel dots as catalysts in the MFR for 8 h at room temperature was studied. The gel dots containing primary amines showed a better conversion of about 83–90% with aliphatic aldehyde and 86–100% with aromatic aldehyde, compared to the tertiary amines (52–59% with aliphatic aldehyde and 77–93% with aromatic aldehydes) which resembles the reactivity of the amines. Moreover, the addition of polar solvent (water) in the reaction mixture and the swelling properties of the gel dots by altering the polymer backbone showed a significant enhancement in the conversion of the reaction, due to the increased accessibility of the catalytic sites in the polymeric network. These results suggested the primary-amine-based catalysts facilitate better conversion compared to tertiary amines and the reaction solvent had a significant influence on organocatalysis to improve the efficiency of MFR.</jats:p>","lang":"eng"}],"keyword":["Knoevenagel reaction","organocatalysis","polymeric gel dots","microfluidic reactions","polymeric networks"],"language":[{"iso":"eng"}]},{"issue":"12","year":"2022","date_created":"2023-01-10T08:02:50Z","publisher":"MDPI AG","title":"Hydrogel-Based Biosensors","publication":"Gels","abstract":[{"lang":"eng","text":"<jats:p>There is an increasing interest in sensing applications for a variety of analytes in aqueous environments, as conventional methods do not work reliably under humid conditions or they require complex equipment with experienced operators. Hydrogel sensors are easy to fabricate, are incredibly sensitive, and have broad dynamic ranges. Experiments on their robustness, reliability, and reusability have indicated the possible long-term applications of these systems in a variety of fields, including disease diagnosis, detection of pharmaceuticals, and in environmental testing. It is possible to produce hydrogels, which, upon sensing a specific analyte, can adsorb it onto their 3D-structure and can therefore be used to remove them from a given environment. High specificity can be obtained by using molecularly imprinted polymers. Typical detection principles involve optical methods including fluorescence and chemiluminescence, and volume changes in colloidal photonic crystals, as well as electrochemical methods. Here, we explore the current research utilizing hydrogel-based sensors in three main areas: (1) biomedical applications, (2) for detecting and quantifying pharmaceuticals of interest, and (3) detecting and quantifying environmental contaminants in aqueous environments.</jats:p>"}],"language":[{"iso":"eng"}],"keyword":["Polymers and Plastics","Organic Chemistry","Biomaterials","Bioengineering"],"publication_identifier":{"issn":["2310-2861"]},"publication_status":"published","intvolume":"         8","citation":{"ieee":"K. Völlmecke <i>et al.</i>, “Hydrogel-Based Biosensors,” <i>Gels</i>, vol. 8, no. 12, Art. no. 768, 2022, doi: <a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>.","chicago":"Völlmecke, Katharina, Rowshon Afroz, Sascha Bierbach, Lee Josephine Brenker, Sebastian Frücht, Alexandra Glass, Ryland Giebelhaus, et al. “Hydrogel-Based Biosensors.” <i>Gels</i> 8, no. 12 (2022). <a href=\"https://doi.org/10.3390/gels8120768\">https://doi.org/10.3390/gels8120768</a>.","ama":"Völlmecke K, Afroz R, Bierbach S, et al. Hydrogel-Based Biosensors. <i>Gels</i>. 2022;8(12). doi:<a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>","apa":"Völlmecke, K., Afroz, R., Bierbach, S., Brenker, L. J., Frücht, S., Glass, A., Giebelhaus, R., Hoppe, A., Kanemaru, K., Lazarek, M., Rabbe, L., Song, L., Velasco Suarez, A., Wu, S., Serpe, M., &#38; Kuckling, D. (2022). Hydrogel-Based Biosensors. <i>Gels</i>, <i>8</i>(12), Article 768. <a href=\"https://doi.org/10.3390/gels8120768\">https://doi.org/10.3390/gels8120768</a>","short":"K. Völlmecke, R. Afroz, S. Bierbach, L.J. Brenker, S. Frücht, A. Glass, R. Giebelhaus, A. Hoppe, K. Kanemaru, M. Lazarek, L. Rabbe, L. Song, A. Velasco Suarez, S. Wu, M. Serpe, D. Kuckling, Gels 8 (2022).","bibtex":"@article{Völlmecke_Afroz_Bierbach_Brenker_Frücht_Glass_Giebelhaus_Hoppe_Kanemaru_Lazarek_et al._2022, title={Hydrogel-Based Biosensors}, volume={8}, DOI={<a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>}, number={12768}, journal={Gels}, publisher={MDPI AG}, author={Völlmecke, Katharina and Afroz, Rowshon and Bierbach, Sascha and Brenker, Lee Josephine and Frücht, Sebastian and Glass, Alexandra and Giebelhaus, Ryland and Hoppe, Axel and Kanemaru, Karen and Lazarek, Michal and et al.}, year={2022} }","mla":"Völlmecke, Katharina, et al. “Hydrogel-Based Biosensors.” <i>Gels</i>, vol. 8, no. 12, 768, MDPI AG, 2022, doi:<a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>."},"volume":8,"author":[{"full_name":"Völlmecke, Katharina","last_name":"Völlmecke","first_name":"Katharina"},{"full_name":"Afroz, Rowshon","last_name":"Afroz","first_name":"Rowshon"},{"first_name":"Sascha","last_name":"Bierbach","full_name":"Bierbach, Sascha"},{"last_name":"Brenker","full_name":"Brenker, Lee Josephine","first_name":"Lee Josephine"},{"first_name":"Sebastian","full_name":"Frücht, Sebastian","last_name":"Frücht"},{"full_name":"Glass, Alexandra","last_name":"Glass","first_name":"Alexandra"},{"first_name":"Ryland","full_name":"Giebelhaus, Ryland","last_name":"Giebelhaus"},{"last_name":"Hoppe","full_name":"Hoppe, Axel","first_name":"Axel"},{"full_name":"Kanemaru, Karen","last_name":"Kanemaru","first_name":"Karen"},{"first_name":"Michal","full_name":"Lazarek, Michal","last_name":"Lazarek"},{"full_name":"Rabbe, Lukas","last_name":"Rabbe","first_name":"Lukas"},{"last_name":"Song","full_name":"Song, Longfei","first_name":"Longfei"},{"last_name":"Velasco Suarez","full_name":"Velasco Suarez, Andrea","first_name":"Andrea"},{"first_name":"Shuang","full_name":"Wu, Shuang","last_name":"Wu"},{"last_name":"Serpe","full_name":"Serpe, Michael","first_name":"Michael"},{"first_name":"Dirk","id":"287","full_name":"Kuckling, Dirk","last_name":"Kuckling"}],"date_updated":"2023-01-10T08:05:30Z","doi":"10.3390/gels8120768","main_file_link":[{"url":"https://www.mdpi.com/2310-2861/8/12/768"}],"type":"journal_article","status":"public","department":[{"_id":"163"}],"user_id":"94","_id":"35642","article_type":"review","article_number":"768"},{"doi":"10.1080/1023666x.2022.2100968","title":"Hyphenation of ultra-high-performance liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined oligomers with different functionalities and tacticity","date_created":"2022-07-26T06:38:52Z","author":[{"full_name":"Berg, Marie-Theres","last_name":"Berg","first_name":"Marie-Theres"},{"last_name":"Herberg","full_name":"Herberg, Artjom","id":"94","first_name":"Artjom"},{"last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk","first_name":"Dirk"}],"publisher":"Informa UK Limited","date_updated":"2023-01-10T08:14:52Z","page":"1-12","citation":{"short":"M.-T. Berg, A. Herberg, D. Kuckling, International Journal of Polymer Analysis and Characterization (2022) 1–12.","mla":"Berg, Marie-Theres, et al. “Hyphenation of Ultra-High-Performance Liquid Chromatography and Ion Mobility Mass Spectrometry for the Analysis of Sequence-Defined Oligomers with Different Functionalities and Tacticity.” <i>International Journal of Polymer Analysis and Characterization</i>, Informa UK Limited, 2022, pp. 1–12, doi:<a href=\"https://doi.org/10.1080/1023666x.2022.2100968\">10.1080/1023666x.2022.2100968</a>.","bibtex":"@article{Berg_Herberg_Kuckling_2022, title={Hyphenation of ultra-high-performance liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined oligomers with different functionalities and tacticity}, DOI={<a href=\"https://doi.org/10.1080/1023666x.2022.2100968\">10.1080/1023666x.2022.2100968</a>}, journal={International Journal of Polymer Analysis and Characterization}, publisher={Informa UK Limited}, author={Berg, Marie-Theres and Herberg, Artjom and Kuckling, Dirk}, year={2022}, pages={1–12} }","apa":"Berg, M.-T., Herberg, A., &#38; Kuckling, D. (2022). Hyphenation of ultra-high-performance liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined oligomers with different functionalities and tacticity. <i>International Journal of Polymer Analysis and Characterization</i>, 1–12. <a href=\"https://doi.org/10.1080/1023666x.2022.2100968\">https://doi.org/10.1080/1023666x.2022.2100968</a>","ama":"Berg M-T, Herberg A, Kuckling D. Hyphenation of ultra-high-performance liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined oligomers with different functionalities and tacticity. <i>International Journal of Polymer Analysis and Characterization</i>. Published online 2022:1-12. doi:<a href=\"https://doi.org/10.1080/1023666x.2022.2100968\">10.1080/1023666x.2022.2100968</a>","chicago":"Berg, Marie-Theres, Artjom Herberg, and Dirk Kuckling. “Hyphenation of Ultra-High-Performance Liquid Chromatography and Ion Mobility Mass Spectrometry for the Analysis of Sequence-Defined Oligomers with Different Functionalities and Tacticity.” <i>International Journal of Polymer Analysis and Characterization</i>, 2022, 1–12. <a href=\"https://doi.org/10.1080/1023666x.2022.2100968\">https://doi.org/10.1080/1023666x.2022.2100968</a>.","ieee":"M.-T. Berg, A. Herberg, and D. Kuckling, “Hyphenation of ultra-high-performance liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined oligomers with different functionalities and tacticity,” <i>International Journal of Polymer Analysis and Characterization</i>, pp. 1–12, 2022, doi: <a href=\"https://doi.org/10.1080/1023666x.2022.2100968\">10.1080/1023666x.2022.2100968</a>."},"year":"2022","publication_identifier":{"issn":["1023-666X","1563-5341"]},"publication_status":"published","language":[{"iso":"eng"}],"keyword":["Ultra-high-performance liquid chromatography","ion mobility separation","mass spectrometry","LC-MS hyphenation","sequence-defined oligomers"],"article_type":"original","department":[{"_id":"163"}],"user_id":"94","_id":"32416","status":"public","abstract":[{"lang":"eng","text":"In recent years, sequence-defined oligomers (SDOs) gained increasing interest due to their perfectly controlled molecular structure, thus providing defined properties. In order to tune the properties, different functionalities need to be incorporated into the oligomers and the chain tacticity needs to be controlled. Beside the synthesis of SDOs, suitable methods need to be found to analyze the molecular structure. In this work, oligomers exhibiting an alternating or block-wise sequence of side chain functionalities were analyzed using a hyphenation of ultra-high-performance liquid chromatography and electrospray ionization mass spectrometry enhanced by ion mobility separation (IMS). Moieties in the side chains were varied according to polarity and bulkiness. Moreover, chain tacticity was varied. Drift times in the IMS cell and the corresponding collision cross section (CCS) values were shown to be individual parameters allowing the identification of SDOs, even in the case that SDO structures only differ in sequence or tacticity of side chain functionalities. Thus, a library of CCS values was obtained as reference used for the analysis of complex mixtures of SDOs."}],"publication":"International Journal of Polymer Analysis and Characterization","type":"journal_article"},{"year":"2022","issue":"12","title":"Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction","date_created":"2023-01-10T08:07:12Z","publisher":"American Chemical Society (ACS)","abstract":[{"lang":"eng","text":"Poly(quinuclidin-3-yl methacrylate-co-divinylbenzene) microparticles having porous as well as nonporous morphology and varying contents of quinuclidine functionality were synthesized by distillation–precipitation polymerization. Further, the synthesized microparticles were explored to catalyze the Baylis–Hillman reaction between 4-nitrobenzaldehyde and acrylonitrile. Porous and nonporous microparticles functionalized with a catalytic moiety with a loading of 70% (labeled as P70 and NP70) were employed to optimize reaction parameters such as water content, solvent, and temperature for the Baylis–Hillman reaction between 4-nitrobenzaldehyde and acrylonitrile. Using optimal conditions, the catalytic efficiency of porous and nonporous microparticles at different feed compositions was determined. Porous microparticles containing 70% of quinuclidine (P70) displayed 100% conversion within 16 h at 50 °C, while nonporous microparticles containing 70% of quinuclidine (NP70) displayed a relatively less catalytic conversion, which is attributed to their lower surface area. Furthermore, the catalytic activity of porous microparticles containing 70% of quinuclidine (P70) for the Baylis–Hillman reaction involving a variety of aryl aldehyde derivatives was determined, where the microparticles displayed impressive catalytic efficiency. In addition, the reusability of the microparticles functionalized with a catalytic moiety was evaluated for five cycles of catalytic reaction."}],"publication":"ACS Applied Polymer Materials","language":[{"iso":"eng"}],"keyword":["distillation−precipitation polymerization","porous microparticles","heterogeneous catalysis Baylis−Hillman reaction","reusable catalyst"],"citation":{"mla":"Kumar, Amit, et al. “Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction.” <i>ACS Applied Polymer Materials</i>, vol. 4, no. 12, American Chemical Society (ACS), 2022, pp. 8996–9005, doi:<a href=\"https://doi.org/10.1021/acsapm.2c01330\">10.1021/acsapm.2c01330</a>.","bibtex":"@article{Kumar_Kuckling_Nebhani_2022, title={Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction}, volume={4}, DOI={<a href=\"https://doi.org/10.1021/acsapm.2c01330\">10.1021/acsapm.2c01330</a>}, number={12}, journal={ACS Applied Polymer Materials}, publisher={American Chemical Society (ACS)}, author={Kumar, Amit and Kuckling, Dirk and Nebhani, Leena}, year={2022}, pages={8996–9005} }","short":"A. Kumar, D. Kuckling, L. Nebhani, ACS Applied Polymer Materials 4 (2022) 8996–9005.","apa":"Kumar, A., Kuckling, D., &#38; Nebhani, L. (2022). Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction. <i>ACS Applied Polymer Materials</i>, <i>4</i>(12), 8996–9005. <a href=\"https://doi.org/10.1021/acsapm.2c01330\">https://doi.org/10.1021/acsapm.2c01330</a>","ama":"Kumar A, Kuckling D, Nebhani L. Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction. <i>ACS Applied Polymer Materials</i>. 2022;4(12):8996-9005. doi:<a href=\"https://doi.org/10.1021/acsapm.2c01330\">10.1021/acsapm.2c01330</a>","ieee":"A. Kumar, D. Kuckling, and L. Nebhani, “Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction,” <i>ACS Applied Polymer Materials</i>, vol. 4, no. 12, pp. 8996–9005, 2022, doi: <a href=\"https://doi.org/10.1021/acsapm.2c01330\">10.1021/acsapm.2c01330</a>.","chicago":"Kumar, Amit, Dirk Kuckling, and Leena Nebhani. “Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction.” <i>ACS Applied Polymer Materials</i> 4, no. 12 (2022): 8996–9005. <a href=\"https://doi.org/10.1021/acsapm.2c01330\">https://doi.org/10.1021/acsapm.2c01330</a>."},"intvolume":"         4","page":"8996-9005","publication_status":"published","publication_identifier":{"issn":["2637-6105","2637-6105"]},"main_file_link":[{"url":"https://pubs.acs.org/doi/10.1021/acsapm.2c01330"}],"doi":"10.1021/acsapm.2c01330","author":[{"last_name":"Kumar","full_name":"Kumar, Amit","first_name":"Amit"},{"id":"287","full_name":"Kuckling, Dirk","last_name":"Kuckling","first_name":"Dirk"},{"first_name":"Leena","full_name":"Nebhani, Leena","last_name":"Nebhani"}],"volume":4,"date_updated":"2023-01-10T08:12:15Z","status":"public","type":"journal_article","article_type":"original","user_id":"94","department":[{"_id":"163"}],"_id":"35645"},{"_id":"32865","department":[{"_id":"163"}],"user_id":"94","keyword":["Size-exclusion chromatography","triple detection","branching analysis","star polymers","poly(N-isopropylacrylamide)","β-cyclodextrin"],"language":[{"iso":"eng"}],"publication":"International Journal of Polymer Analysis and Characterization","type":"journal_article","abstract":[{"lang":"eng","text":"For the first time, poly(N-isopropylacrylamide) (PNIPAAm) star polymers with a β-cyclodextrin core are characterized in detail by size-exclusion chromatography (SEC) with triple detection to experimentally verify the number of arms. A combination of a refractive index detector, multi-angle laser light scattering detector, and an online-viscosimeter was used for branching analysis. At first, the SEC system was calibrated and the detector setup was validated using linear polystyrene reference polymers. The applicability of the established triple detection SEC for branching analysis was shown by the analysis of two commercially available polystyrene star polymers. Due to the high molar masses of the star polymers, both the contraction ratio g and g′ could be determined independently, thus allowing the calculation of the viscosity shielding ratio ε. Finally, the branching analysis of the PNIPAAm star polymers could experimentally confirm the assumed arm number of up to 21 arms. Moreover, an increasingly compact molecular structure and the influence of the arm number on the viscosity shielding ratio could be shown."}],"status":"public","date_updated":"2023-01-10T08:13:52Z","publisher":"Informa UK Limited","author":[{"first_name":"Artjom","last_name":"Herberg","id":"94","full_name":"Herberg, Artjom"},{"first_name":"Dirk","last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk"}],"date_created":"2022-08-17T06:28:55Z","title":"Branching analysis of β-cyclodextrin-based poly(<i>N</i>-isopropylacrylamide) star polymers using triple detection SEC","doi":"10.1080/1023666x.2022.2110133","publication_identifier":{"issn":["1023-666X","1563-5341"]},"publication_status":"published","year":"2022","page":"1-19","citation":{"apa":"Herberg, A., &#38; Kuckling, D. (2022). Branching analysis of β-cyclodextrin-based poly(<i>N</i>-isopropylacrylamide) star polymers using triple detection SEC. <i>International Journal of Polymer Analysis and Characterization</i>, 1–19. <a href=\"https://doi.org/10.1080/1023666x.2022.2110133\">https://doi.org/10.1080/1023666x.2022.2110133</a>","short":"A. Herberg, D. Kuckling, International Journal of Polymer Analysis and Characterization (2022) 1–19.","bibtex":"@article{Herberg_Kuckling_2022, title={Branching analysis of β-cyclodextrin-based poly(<i>N</i>-isopropylacrylamide) star polymers using triple detection SEC}, DOI={<a href=\"https://doi.org/10.1080/1023666x.2022.2110133\">10.1080/1023666x.2022.2110133</a>}, journal={International Journal of Polymer Analysis and Characterization}, publisher={Informa UK Limited}, author={Herberg, Artjom and Kuckling, Dirk}, year={2022}, pages={1–19} }","mla":"Herberg, Artjom, and Dirk Kuckling. “Branching Analysis of β-Cyclodextrin-Based Poly(<i>N</i>-Isopropylacrylamide) Star Polymers Using Triple Detection SEC.” <i>International Journal of Polymer Analysis and Characterization</i>, Informa UK Limited, 2022, pp. 1–19, doi:<a href=\"https://doi.org/10.1080/1023666x.2022.2110133\">10.1080/1023666x.2022.2110133</a>.","ama":"Herberg A, Kuckling D. Branching analysis of β-cyclodextrin-based poly(<i>N</i>-isopropylacrylamide) star polymers using triple detection SEC. <i>International Journal of Polymer Analysis and Characterization</i>. Published online 2022:1-19. doi:<a href=\"https://doi.org/10.1080/1023666x.2022.2110133\">10.1080/1023666x.2022.2110133</a>","ieee":"A. Herberg and D. Kuckling, “Branching analysis of β-cyclodextrin-based poly(<i>N</i>-isopropylacrylamide) star polymers using triple detection SEC,” <i>International Journal of Polymer Analysis and Characterization</i>, pp. 1–19, 2022, doi: <a href=\"https://doi.org/10.1080/1023666x.2022.2110133\">10.1080/1023666x.2022.2110133</a>.","chicago":"Herberg, Artjom, and Dirk Kuckling. “Branching Analysis of β-Cyclodextrin-Based Poly(<i>N</i>-Isopropylacrylamide) Star Polymers Using Triple Detection SEC.” <i>International Journal of Polymer Analysis and Characterization</i>, 2022, 1–19. <a href=\"https://doi.org/10.1080/1023666x.2022.2110133\">https://doi.org/10.1080/1023666x.2022.2110133</a>."}},{"_id":"59617","department":[{"_id":"311"}],"user_id":"62844","article_number":"768","language":[{"iso":"eng"}],"publication":"Gels","type":"journal_article","abstract":[{"lang":"eng","text":"<jats:p>There is an increasing interest in sensing applications for a variety of analytes in aqueous environments, as conventional methods do not work reliably under humid conditions or they require complex equipment with experienced operators. Hydrogel sensors are easy to fabricate, are incredibly sensitive, and have broad dynamic ranges. Experiments on their robustness, reliability, and reusability have indicated the possible long-term applications of these systems in a variety of fields, including disease diagnosis, detection of pharmaceuticals, and in environmental testing. It is possible to produce hydrogels, which, upon sensing a specific analyte, can adsorb it onto their 3D-structure and can therefore be used to remove them from a given environment. High specificity can be obtained by using molecularly imprinted polymers. Typical detection principles involve optical methods including fluorescence and chemiluminescence, and volume changes in colloidal photonic crystals, as well as electrochemical methods. Here, we explore the current research utilizing hydrogel-based sensors in three main areas: (1) biomedical applications, (2) for detecting and quantifying pharmaceuticals of interest, and (3) detecting and quantifying environmental contaminants in aqueous environments.</jats:p>"}],"status":"public","publisher":"MDPI AG","oa":"1","date_updated":"2025-04-22T06:12:07Z","volume":8,"date_created":"2025-04-22T05:59:29Z","author":[{"full_name":"Völlmecke, Katharina","last_name":"Völlmecke","first_name":"Katharina"},{"first_name":"Rowshon","last_name":"Afroz","full_name":"Afroz, Rowshon"},{"full_name":"Bierbach, Sascha","last_name":"Bierbach","first_name":"Sascha"},{"first_name":"Lee Josephine","last_name":"Brenker","full_name":"Brenker, Lee Josephine"},{"first_name":"Sebastian","full_name":"Frücht, Sebastian","last_name":"Frücht"},{"full_name":"Glass, Alexandra","last_name":"Glass","first_name":"Alexandra"},{"full_name":"Giebelhaus, Ryland","last_name":"Giebelhaus","first_name":"Ryland"},{"last_name":"Hoppe","id":"62844","full_name":"Hoppe, Axel","first_name":"Axel"},{"first_name":"Karen","full_name":"Kanemaru, Karen","last_name":"Kanemaru"},{"last_name":"Lazarek","full_name":"Lazarek, Michal","first_name":"Michal"},{"last_name":"Rabbe","full_name":"Rabbe, Lukas","first_name":"Lukas"},{"last_name":"Song","full_name":"Song, Longfei","first_name":"Longfei"},{"first_name":"Andrea","full_name":"Velasco Suarez, Andrea","last_name":"Velasco Suarez"},{"first_name":"Shuang","full_name":"Wu, Shuang","last_name":"Wu"},{"full_name":"Serpe, Michael","last_name":"Serpe","first_name":"Michael"},{"first_name":"Dirk","full_name":"Kuckling, Dirk","id":"287","last_name":"Kuckling"}],"title":"Hydrogel-Based Biosensors","doi":"10.3390/gels8120768","main_file_link":[{"url":"https://www.mdpi.com/2310-2861/8/12/768","open_access":"1"}],"quality_controlled":"1","publication_identifier":{"issn":["2310-2861"]},"publication_status":"published","issue":"12","year":"2022","intvolume":"         8","citation":{"ama":"Völlmecke K, Afroz R, Bierbach S, et al. Hydrogel-Based Biosensors. <i>Gels</i>. 2022;8(12). doi:<a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>","chicago":"Völlmecke, Katharina, Rowshon Afroz, Sascha Bierbach, Lee Josephine Brenker, Sebastian Frücht, Alexandra Glass, Ryland Giebelhaus, et al. “Hydrogel-Based Biosensors.” <i>Gels</i> 8, no. 12 (2022). <a href=\"https://doi.org/10.3390/gels8120768\">https://doi.org/10.3390/gels8120768</a>.","ieee":"K. Völlmecke <i>et al.</i>, “Hydrogel-Based Biosensors,” <i>Gels</i>, vol. 8, no. 12, Art. no. 768, 2022, doi: <a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>.","mla":"Völlmecke, Katharina, et al. “Hydrogel-Based Biosensors.” <i>Gels</i>, vol. 8, no. 12, 768, MDPI AG, 2022, doi:<a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>.","bibtex":"@article{Völlmecke_Afroz_Bierbach_Brenker_Frücht_Glass_Giebelhaus_Hoppe_Kanemaru_Lazarek_et al._2022, title={Hydrogel-Based Biosensors}, volume={8}, DOI={<a href=\"https://doi.org/10.3390/gels8120768\">10.3390/gels8120768</a>}, number={12768}, journal={Gels}, publisher={MDPI AG}, author={Völlmecke, Katharina and Afroz, Rowshon and Bierbach, Sascha and Brenker, Lee Josephine and Frücht, Sebastian and Glass, Alexandra and Giebelhaus, Ryland and Hoppe, Axel and Kanemaru, Karen and Lazarek, Michal and et al.}, year={2022} }","short":"K. Völlmecke, R. Afroz, S. Bierbach, L.J. Brenker, S. Frücht, A. Glass, R. Giebelhaus, A. Hoppe, K. Kanemaru, M. Lazarek, L. Rabbe, L. Song, A. Velasco Suarez, S. Wu, M. Serpe, D. Kuckling, Gels 8 (2022).","apa":"Völlmecke, K., Afroz, R., Bierbach, S., Brenker, L. J., Frücht, S., Glass, A., Giebelhaus, R., Hoppe, A., Kanemaru, K., Lazarek, M., Rabbe, L., Song, L., Velasco Suarez, A., Wu, S., Serpe, M., &#38; Kuckling, D. (2022). Hydrogel-Based Biosensors. <i>Gels</i>, <i>8</i>(12), Article 768. <a href=\"https://doi.org/10.3390/gels8120768\">https://doi.org/10.3390/gels8120768</a>"}},{"status":"public","publication":"International Journal of Pharmaceutics","type":"journal_article","language":[{"iso":"eng"}],"article_number":"120326","department":[{"_id":"311"}],"user_id":"94","_id":"23701","intvolume":"       597","citation":{"apa":"Schoppa, T., Jung, D., Rust, T., Mulac, D., Kuckling, D., &#38; Langer, K. (2021). Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT. <i>International Journal of Pharmaceutics</i>, <i>597</i>, Article 120326. <a href=\"https://doi.org/10.1016/j.ijpharm.2021.120326\">https://doi.org/10.1016/j.ijpharm.2021.120326</a>","short":"T. Schoppa, D. Jung, T. Rust, D. Mulac, D. Kuckling, K. Langer, International Journal of Pharmaceutics 597 (2021).","bibtex":"@article{Schoppa_Jung_Rust_Mulac_Kuckling_Langer_2021, title={Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT}, volume={597}, DOI={<a href=\"https://doi.org/10.1016/j.ijpharm.2021.120326\">10.1016/j.ijpharm.2021.120326</a>}, number={120326}, journal={International Journal of Pharmaceutics}, publisher={Elsevier}, author={Schoppa, Timo and Jung, Dimitri and Rust, Tarik and Mulac, Dennis and Kuckling, Dirk and Langer, Klaus}, year={2021} }","mla":"Schoppa, Timo, et al. “Light-Responsive Polymeric Nanoparticles Based on a Novel Nitropiperonal Based Polyester as Drug Delivery Systems for Photosensitizers in PDT.” <i>International Journal of Pharmaceutics</i>, vol. 597, 120326, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.ijpharm.2021.120326\">10.1016/j.ijpharm.2021.120326</a>.","chicago":"Schoppa, Timo, Dimitri Jung, Tarik Rust, Dennis Mulac, Dirk Kuckling, and Klaus Langer. “Light-Responsive Polymeric Nanoparticles Based on a Novel Nitropiperonal Based Polyester as Drug Delivery Systems for Photosensitizers in PDT.” <i>International Journal of Pharmaceutics</i> 597 (2021). <a href=\"https://doi.org/10.1016/j.ijpharm.2021.120326\">https://doi.org/10.1016/j.ijpharm.2021.120326</a>.","ieee":"T. Schoppa, D. Jung, T. Rust, D. Mulac, D. Kuckling, and K. Langer, “Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT,” <i>International Journal of Pharmaceutics</i>, vol. 597, Art. no. 120326, 2021, doi: <a href=\"https://doi.org/10.1016/j.ijpharm.2021.120326\">10.1016/j.ijpharm.2021.120326</a>.","ama":"Schoppa T, Jung D, Rust T, Mulac D, Kuckling D, Langer K. Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT. <i>International Journal of Pharmaceutics</i>. 2021;597. doi:<a href=\"https://doi.org/10.1016/j.ijpharm.2021.120326\">10.1016/j.ijpharm.2021.120326</a>"},"year":"2021","publication_identifier":{"issn":["0378-5173"]},"publication_status":"published","doi":"10.1016/j.ijpharm.2021.120326","title":"Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT","volume":597,"date_created":"2021-09-02T12:48:00Z","author":[{"last_name":"Schoppa","full_name":"Schoppa, Timo","first_name":"Timo"},{"first_name":"Dimitri","last_name":"Jung","full_name":"Jung, Dimitri"},{"full_name":"Rust, Tarik","last_name":"Rust","first_name":"Tarik"},{"last_name":"Mulac","full_name":"Mulac, Dennis","first_name":"Dennis"},{"first_name":"Dirk","full_name":"Kuckling, Dirk","id":"287","last_name":"Kuckling"},{"first_name":"Klaus","full_name":"Langer, Klaus","last_name":"Langer"}],"date_updated":"2022-07-28T09:57:44Z","publisher":"Elsevier"},{"user_id":"94","department":[{"_id":"311"}],"_id":"23662","language":[{"iso":"eng"}],"type":"journal_article","publication":"ACS Applied Polymer Materials","status":"public","date_created":"2021-09-02T06:41:16Z","author":[{"first_name":"Tarik","last_name":"Rust","full_name":"Rust, Tarik"},{"first_name":"Dimitri","last_name":"Jung","full_name":"Jung, Dimitri"},{"first_name":"Axel","last_name":"Hoppe","full_name":"Hoppe, Axel"},{"first_name":"Timo","full_name":"Schoppa, Timo","last_name":"Schoppa"},{"full_name":"Langer, Klaus","last_name":"Langer","first_name":"Klaus"},{"last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk","first_name":"Dirk"}],"volume":3,"publisher":"ACS","date_updated":"2022-07-28T10:00:40Z","doi":"10.1021/acsapm.1c00411","title":"Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery","issue":"8","publication_status":"published","publication_identifier":{"issn":["2637-6105","2637-6105"]},"citation":{"apa":"Rust, T., Jung, D., Hoppe, A., Schoppa, T., Langer, K., &#38; Kuckling, D. (2021). Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery. <i>ACS Applied Polymer Materials</i>, <i>3</i>(8), 3831–3842. <a href=\"https://doi.org/10.1021/acsapm.1c00411\">https://doi.org/10.1021/acsapm.1c00411</a>","bibtex":"@article{Rust_Jung_Hoppe_Schoppa_Langer_Kuckling_2021, title={Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery}, volume={3}, DOI={<a href=\"https://doi.org/10.1021/acsapm.1c00411\">10.1021/acsapm.1c00411</a>}, number={8}, journal={ACS Applied Polymer Materials}, publisher={ACS}, author={Rust, Tarik and Jung, Dimitri and Hoppe, Axel and Schoppa, Timo and Langer, Klaus and Kuckling, Dirk}, year={2021}, pages={3831–3842} }","mla":"Rust, Tarik, et al. “Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery.” <i>ACS Applied Polymer Materials</i>, vol. 3, no. 8, ACS, 2021, pp. 3831–42, doi:<a href=\"https://doi.org/10.1021/acsapm.1c00411\">10.1021/acsapm.1c00411</a>.","short":"T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, D. Kuckling, ACS Applied Polymer Materials 3 (2021) 3831–3842.","ieee":"T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, and D. Kuckling, “Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery,” <i>ACS Applied Polymer Materials</i>, vol. 3, no. 8, pp. 3831–3842, 2021, doi: <a href=\"https://doi.org/10.1021/acsapm.1c00411\">10.1021/acsapm.1c00411</a>.","chicago":"Rust, Tarik, Dimitri Jung, Axel Hoppe, Timo Schoppa, Klaus Langer, and Dirk Kuckling. “Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery.” <i>ACS Applied Polymer Materials</i> 3, no. 8 (2021): 3831–42. <a href=\"https://doi.org/10.1021/acsapm.1c00411\">https://doi.org/10.1021/acsapm.1c00411</a>.","ama":"Rust T, Jung D, Hoppe A, Schoppa T, Langer K, Kuckling D. Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery. <i>ACS Applied Polymer Materials</i>. 2021;3(8):3831-3842. doi:<a href=\"https://doi.org/10.1021/acsapm.1c00411\">10.1021/acsapm.1c00411</a>"},"page":"3831-3842","intvolume":"         3","year":"2021"},{"publication":"European Journal of Organic Chemistry","type":"journal_article","status":"public","department":[{"_id":"311"}],"user_id":"94","_id":"23699","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1434-193X","1099-0690"]},"publication_status":"published","page":"2578-2586","citation":{"mla":"Schmiegel, Carsten J., et al. “Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts.” <i>European Journal of Organic Chemistry</i>, Wiley-VCH, 2021, pp. 2578–86, doi:<a href=\"https://doi.org/10.1002/ejoc.202100268\">10.1002/ejoc.202100268</a>.","short":"C.J. Schmiegel, R. Baier, D. Kuckling, European Journal of Organic Chemistry (2021) 2578–2586.","bibtex":"@article{Schmiegel_Baier_Kuckling_2021, title={Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts}, DOI={<a href=\"https://doi.org/10.1002/ejoc.202100268\">10.1002/ejoc.202100268</a>}, journal={European Journal of Organic Chemistry}, publisher={Wiley-VCH}, author={Schmiegel, Carsten J. and Baier, Rene and Kuckling, Dirk}, year={2021}, pages={2578–2586} }","apa":"Schmiegel, C. J., Baier, R., &#38; Kuckling, D. (2021). Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts. <i>European Journal of Organic Chemistry</i>, 2578–2586. <a href=\"https://doi.org/10.1002/ejoc.202100268\">https://doi.org/10.1002/ejoc.202100268</a>","ama":"Schmiegel CJ, Baier R, Kuckling D. Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts. <i>European Journal of Organic Chemistry</i>. Published online 2021:2578-2586. doi:<a href=\"https://doi.org/10.1002/ejoc.202100268\">10.1002/ejoc.202100268</a>","ieee":"C. J. Schmiegel, R. Baier, and D. Kuckling, “Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts,” <i>European Journal of Organic Chemistry</i>, pp. 2578–2586, 2021, doi: <a href=\"https://doi.org/10.1002/ejoc.202100268\">10.1002/ejoc.202100268</a>.","chicago":"Schmiegel, Carsten J., Rene Baier, and Dirk Kuckling. “Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts.” <i>European Journal of Organic Chemistry</i>, 2021, 2578–86. <a href=\"https://doi.org/10.1002/ejoc.202100268\">https://doi.org/10.1002/ejoc.202100268</a>."},"year":"2021","author":[{"full_name":"Schmiegel, Carsten J.","last_name":"Schmiegel","first_name":"Carsten J."},{"full_name":"Baier, Rene","last_name":"Baier","first_name":"Rene"},{"last_name":"Kuckling","id":"287","full_name":"Kuckling, Dirk","first_name":"Dirk"}],"date_created":"2021-09-02T12:44:25Z","publisher":"Wiley-VCH","date_updated":"2022-07-28T09:57:57Z","doi":"10.1002/ejoc.202100268","title":"Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts"}]