---
_id: '64873'
abstract:
- lang: eng
text: Continuous flow catalysis utilizing gel-bound organocatalysts within a microfluidic
reactor represents a compelling strategy in the realm of organic synthesis. In
this study, a quinuclidine-based catalytic monomer (QMA) was synthesized to create
polymer gel dots through the process of photopolymerization that serve as a support
for the catalyst. The resulting gel-bound organocatalysts were assembled within
a continuous microfluidic reactor to facilitate the Baylis–Hillman reaction between
various aldehydes and acrylonitrile at a temperature of 50 °C. The conversion
of the product was assessed using 1H NMR spectroscopy as an offline analytical
method over a duration of 8 h. The findings indicated that highly reactive aldehydes
achieved conversion rates exceeding 90%, in contrast to their less reactive counterparts.
Furthermore, these results were juxtaposed with previously published data derived
from alternative synthetic methodologies, revealing that the continuous microfluidic
reactions employing integrated organocatalysts within polymer networks exhibited
significantly higher conversions with reduced reaction times (8 h) at the same
temperature (50 °C). Additionally, the influence of different geometries (round,
triangular, and square) of the gel dots on catalytic activity was investigated,
with round and square gel dots demonstrating slightly superior performance compared
with triangular gel dots, attributed to their increased surface area. Moreover,
an extended reaction period of 6 days was conducted using 4-bromobenzaldehyde
and acrylonitrile, resulting in a conversion rate exceeding 70%, which remained
stable for 5 days before experiencing a slight decline due to product accumulation
on the gel dots.
article_number: '14448'
article_type: original
author:
- first_name: Naresh
full_name: Killi, Naresh
last_name: Killi
- first_name: Amit
full_name: Kumar, Amit
last_name: Kumar
- first_name: Leena
full_name: Nebhani, Leena
last_name: Nebhani
- first_name: Franziska
full_name: Obst, Franziska
last_name: Obst
- first_name: Andreas
full_name: Richter, Andreas
last_name: Richter
- first_name: Bernhard
full_name: Reineke Matsudo, Bernhard
last_name: Reineke Matsudo
- first_name: Thomas
full_name: Zentgraf, Thomas
id: '30525'
last_name: Zentgraf
orcid: 0000-0002-8662-1101
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Killi N, Kumar A, Nebhani L, et al. Integrating an Organocatalyst into a Polymeric
Gel Framework for the Continuous Microflow Baylis–Hillman Reaction. ACS Omega.
2026;11(9). doi:10.1021/acsomega.5c09476
apa: Killi, N., Kumar, A., Nebhani, L., Obst, F., Richter, A., Reineke Matsudo,
B., Zentgraf, T., & Kuckling, D. (2026). Integrating an Organocatalyst into
a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction.
ACS Omega, 11(9), Article 14448. https://doi.org/10.1021/acsomega.5c09476
bibtex: '@article{Killi_Kumar_Nebhani_Obst_Richter_Reineke Matsudo_Zentgraf_Kuckling_2026,
title={Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous
Microflow Baylis–Hillman Reaction}, volume={11}, DOI={10.1021/acsomega.5c09476},
number={914448}, journal={ACS Omega}, publisher={American Chemical Society (ACS)},
author={Killi, Naresh and Kumar, Amit and Nebhani, Leena and Obst, Franziska and
Richter, Andreas and Reineke Matsudo, Bernhard and Zentgraf, Thomas and Kuckling,
Dirk}, year={2026} }'
chicago: Killi, Naresh, Amit Kumar, Leena Nebhani, Franziska Obst, Andreas Richter,
Bernhard Reineke Matsudo, Thomas Zentgraf, and Dirk Kuckling. “Integrating an
Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman
Reaction.” ACS Omega 11, no. 9 (2026). https://doi.org/10.1021/acsomega.5c09476.
ieee: 'N. Killi et al., “Integrating an Organocatalyst into a Polymeric Gel
Framework for the Continuous Microflow Baylis–Hillman Reaction,” ACS Omega,
vol. 11, no. 9, Art. no. 14448, 2026, doi: 10.1021/acsomega.5c09476.'
mla: Killi, Naresh, et al. “Integrating an Organocatalyst into a Polymeric Gel Framework
for the Continuous Microflow Baylis–Hillman Reaction.” ACS Omega, vol.
11, no. 9, 14448, American Chemical Society (ACS), 2026, doi:10.1021/acsomega.5c09476.
short: N. Killi, A. Kumar, L. Nebhani, F. Obst, A. Richter, B. Reineke Matsudo,
T. Zentgraf, D. Kuckling, ACS Omega 11 (2026).
date_created: 2026-03-10T08:23:43Z
date_updated: 2026-03-10T08:27:15Z
department:
- _id: '15'
- _id: '230'
- _id: '289'
- _id: '623'
- _id: '2'
- _id: '311'
doi: 10.1021/acsomega.5c09476
intvolume: ' 11'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubs.acs.org/doi/abs/10.1021/acsomega.5c09476
oa: '1'
publication: ACS Omega
publication_identifier:
issn:
- 2470-1343
- 2470-1343
publication_status: published
publisher: American Chemical Society (ACS)
quality_controlled: '1'
status: public
title: Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous
Microflow Baylis–Hillman Reaction
type: journal_article
user_id: '30525'
volume: 11
year: '2026'
...
---
_id: '59510'
abstract:
- lang: eng
text: The use of organo-catalysis in continuous-flow reactor systems is
gaining attention in medicinal chemistry due to its cost-effectiveness and reduced
chemical waste. In this study, bioactive curcumin (CUM) derivatives were synthesized
in a continuously operated microfluidic reactor (MFR), using piperidine-based
polymeric networks as catalysts. Piperidine methacrylate and piperidine acrylate
were synthesized and subsequently copolymerized with complementary monomers (MMA
or DMAA) and crosslinkers (EGDMA or MBAM) via photopolymerization, yielding different
polymeric networks. Initially, batch reactions were optimized for the organo-catalytic
Knoevenagel condensation between CUM and 4-nitrobenzaldehyde, under various conditions,
in the presence of polymer networks. Conversion was assessed using offline 1H
NMR spectroscopy, revealing an increase in conversion with enhanced swelling properties
of the polymer networks, which facilitated greater accessibility of catalytic
sites. In continuous-flow MFR experiments, optimized polymer gel dots exhibited
superior catalytic performance, achieving a conversion of up to 72%, compared
to other compositions. This improvement was attributed to the enhanced swelling
in the reaction mixture (DMSO/methanol, 7:3 v/v) at 40 °C over 72 h. Furthermore,
the MFR system enabled the efficient synthesis of a series of CUM derivatives,
demonstrating significantly higher conversion rates than traditional batch reactions.
Notably, while batch reactions required 90% catalyst loading in the gel, the MFR
system achieved a comparable or superior performance with only 50% catalyst, resulting
in a higher turnover number. These findings underscore the advantages of continuous-flow
organo-catalysis in enhancing catalytic efficiency and sustainability in organic
synthesis.
article_number: '278'
author:
- first_name: Naresh
full_name: Killi, Naresh
last_name: Killi
- first_name: Katja
full_name: Rumpke, Katja
last_name: Rumpke
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Killi N, Rumpke K, Kuckling D. Synthesis of Curcumin Derivatives via Knoevenagel
Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks
Containing Piperidine as a Catalyst. Gels. 2025;11(4). doi:10.3390/gels11040278
apa: Killi, N., Rumpke, K., & Kuckling, D. (2025). Synthesis of Curcumin Derivatives
via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using
Polymeric Networks Containing Piperidine as a Catalyst. Gels, 11(4),
Article 278. https://doi.org/10.3390/gels11040278
bibtex: '@article{Killi_Rumpke_Kuckling_2025, title={Synthesis of Curcumin Derivatives
via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using
Polymeric Networks Containing Piperidine as a Catalyst}, volume={11}, DOI={10.3390/gels11040278}, number={4278},
journal={Gels}, publisher={MDPI AG}, author={Killi, Naresh and Rumpke, Katja and
Kuckling, Dirk}, year={2025} }'
chicago: Killi, Naresh, Katja Rumpke, and Dirk Kuckling. “Synthesis of Curcumin
Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic
Reactor Using Polymeric Networks Containing Piperidine as a Catalyst.” Gels
11, no. 4 (2025). https://doi.org/10.3390/gels11040278.
ieee: 'N. Killi, K. Rumpke, and D. Kuckling, “Synthesis of Curcumin Derivatives
via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using
Polymeric Networks Containing Piperidine as a Catalyst,” Gels, vol. 11,
no. 4, Art. no. 278, 2025, doi: 10.3390/gels11040278.'
mla: Killi, Naresh, et al. “Synthesis of Curcumin Derivatives via Knoevenagel Reaction
Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing
Piperidine as a Catalyst.” Gels, vol. 11, no. 4, 278, MDPI AG, 2025, doi:10.3390/gels11040278.
short: N. Killi, K. Rumpke, D. Kuckling, Gels 11 (2025).
date_created: 2025-04-11T07:12:02Z
date_updated: 2025-04-11T07:13:26Z
department:
- _id: '163'
doi: 10.3390/gels11040278
intvolume: ' 11'
issue: '4'
keyword:
- flow chemistry
- heterogeneous catalysis
- sustainable synthesis
- organo-catalysis
- polymeric gel dots
language:
- iso: eng
main_file_link:
- url: https://www.mdpi.com/2310-2861/11/4/278
publication: Gels
publication_identifier:
issn:
- 2310-2861
publication_status: published
publisher: MDPI AG
status: public
title: Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously
Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a
Catalyst
type: journal_article
user_id: '94'
volume: 11
year: '2025'
...
---
_id: '59511'
abstract:
- lang: eng
text: AbstractTo minimize or avoid the use of antibiotics,
antimicrobial polymers have emerged as a promising option to fight biomaterial‐associated
infections, e.g., on titanium‐based implants. However, the challenge is to develop
active polymers that exhibit an antimicrobial effect and are compatible with human
cells. Different studies aiming for biocidal polymers active in soluble mode,
focused on the ratio of cationic to hydrophobic groups, while only marginal knowledge
is available for immobilized components. Here a strong hydrophilic electrolyte
4‐vinylbenzyltrimethylammonium chloride (TMA) is chosen as the cationic component.
The block composition of the polycationic segment is modified with styrene (Sty)
regarding the amphiphilic balance. To adsorb such polymers onto titanium surfaces
they are equipped with a polyphosphonic acid anchor block by sequential reversible‐addition‐fragmentation
chain‐transfer polymerization (RAFT) polymerization. The polymer composition affected
the wetting behavior of adsorbed coatings with water contact angles ranging from
17° to 72°, while zetapotential measurements confirmed high extent of positive
charges for all adsorbed polymer coatings. The fundamentally modified block composition
resulted in significantly improved cytocompatibility. Antimicrobial efficacy in
early bacterial adhesion is still retained from slightly antiadhesive coatings
to combined antiadhesive/biocidal activity depending on Sty/TMA ratio in random
polymers while a block copolymer revealed lowest antimicrobial effect.
author:
- first_name: Cornelia
full_name: Wolf‐Brandstetter, Cornelia
last_name: Wolf‐Brandstetter
- first_name: Rafael
full_name: Methling, Rafael
last_name: Methling
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Wolf‐Brandstetter C, Methling R, Kuckling D. Adsorbable and Antimicrobial Amphiphilic
Block Copolymers with Enhanced Biocompatibility. Macromolecular Materials and
Engineering. Published online 2025. doi:10.1002/mame.202500078
apa: Wolf‐Brandstetter, C., Methling, R., & Kuckling, D. (2025). Adsorbable
and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.
Macromolecular Materials and Engineering. https://doi.org/10.1002/mame.202500078
bibtex: '@article{Wolf‐Brandstetter_Methling_Kuckling_2025, title={Adsorbable and
Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility}, DOI={10.1002/mame.202500078}, journal={Macromolecular
Materials and Engineering}, publisher={Wiley}, author={Wolf‐Brandstetter, Cornelia
and Methling, Rafael and Kuckling, Dirk}, year={2025} }'
chicago: Wolf‐Brandstetter, Cornelia, Rafael Methling, and Dirk Kuckling. “Adsorbable
and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.”
Macromolecular Materials and Engineering, 2025. https://doi.org/10.1002/mame.202500078.
ieee: 'C. Wolf‐Brandstetter, R. Methling, and D. Kuckling, “Adsorbable and Antimicrobial
Amphiphilic Block Copolymers with Enhanced Biocompatibility,” Macromolecular
Materials and Engineering, 2025, doi: 10.1002/mame.202500078.'
mla: Wolf‐Brandstetter, Cornelia, et al. “Adsorbable and Antimicrobial Amphiphilic
Block Copolymers with Enhanced Biocompatibility.” Macromolecular Materials
and Engineering, Wiley, 2025, doi:10.1002/mame.202500078.
short: C. Wolf‐Brandstetter, R. Methling, D. Kuckling, Macromolecular Materials
and Engineering (2025).
date_created: 2025-04-11T07:35:39Z
date_updated: 2025-04-11T07:43:06Z
department:
- _id: '163'
doi: 10.1002/mame.202500078
keyword:
- antiadhesive surfaces
- antimicrobial polymers
- grafting to
- polymerbrushes
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500078
publication: Macromolecular Materials and Engineering
publication_identifier:
issn:
- 1438-7492
- 1439-2054
publication_status: published
publisher: Wiley
status: public
title: Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility
type: journal_article
user_id: '94'
year: '2025'
...
---
_id: '64884'
abstract:
- lang: eng
text: "To address the challenges associated with poor drug solubility and uncontrolled
drug release in conventional dosage forms, a combination of polymer design and
advanced drug delivery approaches has been employed. The development of pH-responsive
nanoparticles for controlled and selective drug release represents a notable advance
in adaptive nanomedicine. This study explores the design of a pH-responsive polymer,
poly(1,4-phenyleneacetone dimethylene ketal) (PPADK). Additionally, the incorporation
of light-responsive ortho-nitrobenzyl groups (o-NB-PPADK) enhanced the degradation
upon exposure to light. Based on the polymer, nanoparticles were prepared using
the solvent displacement method. The fluorescence dye Lumogen® Red was incorporated
as a model substance. The nanoparticles were characterized by dynamic light scattering
to determine their hydrodynamic diameter and size distribution, and the surface
charge was analyzed. Atomic force microscopy was used to visualize the surface
morphology. The nanoparticles remained stable under physiological pH conditions
while exhibiting accelerated degradation and substance release in acidic environment,
a property potentially exploitable for tumor targeting. Further enhanced degradation
and correspondingly increased release was achieved by incorporating light-responsive
elements in the polymer structure.\r\nThe cytotoxicity of these newly designed
nanoparticles was evaluated in cell culture using a breast cancer cell line. These
results support the potential of o-NB-PPADK nanoparticles as a possible candidate
for selective and effective cancer therapy, combining stimuli-responsive degradation
mechanisms for improved therapeutic outcomes."
article_number: '126127'
article_type: original
author:
- first_name: Maurice
full_name: Kramer, Maurice
last_name: Kramer
- first_name: Matthias
full_name: van der Linde, Matthias
last_name: van der Linde
- first_name: Lisa
full_name: Hönscheid, Lisa
last_name: Hönscheid
- first_name: Corinna
full_name: Horky, Corinna
last_name: Horky
- first_name: Katharina
full_name: Völlmecke, Katharina
last_name: Völlmecke
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Fabian
full_name: Herrmann, Fabian
last_name: Herrmann
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
citation:
ama: 'Kramer M, van der Linde M, Hönscheid L, et al. Enlightening release strategies:
Accelerated nanoparticle degradation and substance release utilizing light- and
pH-responsive polymers. International Journal of Pharmaceutics. 2025;684.
doi:10.1016/j.ijpharm.2025.126127'
apa: 'Kramer, M., van der Linde, M., Hönscheid, L., Horky, C., Völlmecke, K., Mulac,
D., Herrmann, F., Kuckling, D., & Langer, K. (2025). Enlightening release
strategies: Accelerated nanoparticle degradation and substance release utilizing
light- and pH-responsive polymers. International Journal of Pharmaceutics,
684, Article 126127. https://doi.org/10.1016/j.ijpharm.2025.126127'
bibtex: '@article{Kramer_van der Linde_Hönscheid_Horky_Völlmecke_Mulac_Herrmann_Kuckling_Langer_2025,
title={Enlightening release strategies: Accelerated nanoparticle degradation and
substance release utilizing light- and pH-responsive polymers}, volume={684},
DOI={10.1016/j.ijpharm.2025.126127},
number={126127}, journal={International Journal of Pharmaceutics}, publisher={Elsevier
BV}, author={Kramer, Maurice and van der Linde, Matthias and Hönscheid, Lisa and
Horky, Corinna and Völlmecke, Katharina and Mulac, Dennis and Herrmann, Fabian
and Kuckling, Dirk and Langer, Klaus}, year={2025} }'
chicago: 'Kramer, Maurice, Matthias van der Linde, Lisa Hönscheid, Corinna Horky,
Katharina Völlmecke, Dennis Mulac, Fabian Herrmann, Dirk Kuckling, and Klaus Langer.
“Enlightening Release Strategies: Accelerated Nanoparticle Degradation and Substance
Release Utilizing Light- and PH-Responsive Polymers.” International Journal
of Pharmaceutics 684 (2025). https://doi.org/10.1016/j.ijpharm.2025.126127.'
ieee: 'M. Kramer et al., “Enlightening release strategies: Accelerated nanoparticle
degradation and substance release utilizing light- and pH-responsive polymers,”
International Journal of Pharmaceutics, vol. 684, Art. no. 126127, 2025,
doi: 10.1016/j.ijpharm.2025.126127.'
mla: 'Kramer, Maurice, et al. “Enlightening Release Strategies: Accelerated Nanoparticle
Degradation and Substance Release Utilizing Light- and PH-Responsive Polymers.”
International Journal of Pharmaceutics, vol. 684, 126127, Elsevier BV,
2025, doi:10.1016/j.ijpharm.2025.126127.'
short: M. Kramer, M. van der Linde, L. Hönscheid, C. Horky, K. Völlmecke, D. Mulac,
F. Herrmann, D. Kuckling, K. Langer, International Journal of Pharmaceutics 684
(2025).
date_created: 2026-03-11T08:46:17Z
date_updated: 2026-03-11T08:52:22Z
department:
- _id: '163'
doi: 10.1016/j.ijpharm.2025.126127
intvolume: ' 684'
keyword:
- Nanoparticles
- Drug delivery
- Controlled release
- Stimuli-responsiveTumor targeting
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/S0378517325009640?via%3Dihub
publication: International Journal of Pharmaceutics
publication_identifier:
issn:
- 0378-5173
publication_status: published
publisher: Elsevier BV
status: public
title: 'Enlightening release strategies: Accelerated nanoparticle degradation and
substance release utilizing light- and pH-responsive polymers'
type: journal_article
user_id: '94'
volume: 684
year: '2025'
...
---
_id: '64885'
abstract:
- lang: eng
text: 'The tribological behavior of thermo‐responsive poly(N‐isopropylacrylamide)
(PNIPAAm)‐based microgels is investigated for use as water‐dispersible lubricant
additives. Two types of microgels are synthesized using a surfactant‐free emulsion
polymerization method: MG0, consisting of pure PNIPAAm with a volume phase transition
temperature (VPTT) of ≈33 °C, and MG16, consisting of PNIPAAm copolymerized with
hydrophobic tert‐butyl acrylamide, exhibiting a lower VPTT of around 23 °C. Swelling
and lubrication performance are evaluated at 20 and 40 °C. Both microgels significantly
reduce friction and wear compared to water alone. At 20 °C, MG0 remains fully
swollen and provides effective wear protection through hydrated microgel lubrication.
MG16, being near its VPTT, exhibits partial collapse and slightly higher wear.
At 40 °C, MG16 demonstrates improved wear resistance, attributed to enhanced film
compaction in the collapsed state. Raman spectroscopy and scanning electron microscopy–energy‐dispersive
X‐ray spectroscopy confirm that carbon‐rich tribofilms are formed via tribochemical
reactions. MG0 produces more graphitic films, while MG16 generates amorphous carbon
structures. These findings highlight the tunability of microgel composition for
designing adaptive, water‐based lubricants for temperature‐sensitive applications.'
article_number: e202501673
article_type: original
author:
- first_name: Junaid
full_name: Syed, Junaid
last_name: Syed
- first_name: Florian
full_name: Dyck, Florian
last_name: Dyck
- first_name: Artjom
full_name: Herberg, Artjom
id: '94'
last_name: Herberg
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Nitya Nand
full_name: Gosvami, Nitya Nand
last_name: Gosvami
citation:
ama: 'Syed J, Dyck F, Herberg A, Kuckling D, Gosvami NN. Microgel Additives for
Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal Responsiveness.
Advanced Engineering Materials. 2025;28(1). doi:10.1002/adem.202501673'
apa: 'Syed, J., Dyck, F., Herberg, A., Kuckling, D., & Gosvami, N. N. (2025).
Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via Composition
and Thermal Responsiveness. Advanced Engineering Materials, 28(1),
Article e202501673. https://doi.org/10.1002/adem.202501673'
bibtex: '@article{Syed_Dyck_Herberg_Kuckling_Gosvami_2025, title={Microgel Additives
for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal
Responsiveness}, volume={28}, DOI={10.1002/adem.202501673},
number={1e202501673}, journal={Advanced Engineering Materials}, publisher={Wiley},
author={Syed, Junaid and Dyck, Florian and Herberg, Artjom and Kuckling, Dirk
and Gosvami, Nitya Nand}, year={2025} }'
chicago: 'Syed, Junaid, Florian Dyck, Artjom Herberg, Dirk Kuckling, and Nitya Nand
Gosvami. “Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear
via Composition and Thermal Responsiveness.” Advanced Engineering Materials
28, no. 1 (2025). https://doi.org/10.1002/adem.202501673.'
ieee: 'J. Syed, F. Dyck, A. Herberg, D. Kuckling, and N. N. Gosvami, “Microgel Additives
for Aqueous Lubrication: Tailoring Friction and Wear via Composition and Thermal
Responsiveness,” Advanced Engineering Materials, vol. 28, no. 1, Art. no.
e202501673, 2025, doi: 10.1002/adem.202501673.'
mla: 'Syed, Junaid, et al. “Microgel Additives for Aqueous Lubrication: Tailoring
Friction and Wear via Composition and Thermal Responsiveness.” Advanced Engineering
Materials, vol. 28, no. 1, e202501673, Wiley, 2025, doi:10.1002/adem.202501673.'
short: J. Syed, F. Dyck, A. Herberg, D. Kuckling, N.N. Gosvami, Advanced Engineering
Materials 28 (2025).
date_created: 2026-03-11T08:53:17Z
date_updated: 2026-03-11T08:56:26Z
department:
- _id: '163'
doi: 10.1002/adem.202501673
intvolume: ' 28'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adem.202501673
publication: Advanced Engineering Materials
publication_identifier:
issn:
- 1438-1656
- 1527-2648
publication_status: published
publisher: Wiley
status: public
title: 'Microgel Additives for Aqueous Lubrication: Tailoring Friction and Wear via
Composition and Thermal Responsiveness'
type: journal_article
user_id: '94'
volume: 28
year: '2025'
...
---
_id: '52541'
abstract:
- lang: eng
text: AbstractWe conducted an investigation into
the palladium‐catalyzed carbon‐sulfur cross‐coupling reaction involving a 2‐bromothiophene
derivative and potassium thioacetate as a substitute for hydrogen sulfide. This
investigation utilized kinetic and computational methods. We synthesized two palladium
complexes supported by the bisphosphane ligands bis(diphenylphosphino)ferrocene
(DPPF) and bis(diisopropylphosphino)ferrocene (DiPPF),
as well as their tentative intermediates in the catalytic cycle. Reaction rates
were measured and then compared to computational predictions.
author:
- first_name: Sebastian
full_name: Peschtrich, Sebastian
last_name: Peschtrich
- first_name: Roland
full_name: Schoch, Roland
id: '48467'
last_name: Schoch
orcid: 0000-0003-2061-7289
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Jan
full_name: Paradies, Jan
id: '53339'
last_name: Paradies
orcid: 0000-0002-3698-668X
citation:
ama: Peschtrich S, Schoch R, Kuckling D, Paradies J. A Comparative Kinetic and Computational
Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and
2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes. European Journal
of Organic Chemistry. 2024;27(8). doi:10.1002/ejoc.202301207
apa: Peschtrich, S., Schoch, R., Kuckling, D., & Paradies, J. (2024). A Comparative
Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of
Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes.
European Journal of Organic Chemistry, 27(8). https://doi.org/10.1002/ejoc.202301207
bibtex: '@article{Peschtrich_Schoch_Kuckling_Paradies_2024, title={A Comparative
Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of
Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes},
volume={27}, DOI={10.1002/ejoc.202301207},
number={8}, journal={European Journal of Organic Chemistry}, publisher={Wiley},
author={Peschtrich, Sebastian and Schoch, Roland and Kuckling, Dirk and Paradies,
Jan}, year={2024} }'
chicago: Peschtrich, Sebastian, Roland Schoch, Dirk Kuckling, and Jan Paradies.
“A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross
Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine
Complexes.” European Journal of Organic Chemistry 27, no. 8 (2024). https://doi.org/10.1002/ejoc.202301207.
ieee: 'S. Peschtrich, R. Schoch, D. Kuckling, and J. Paradies, “A Comparative Kinetic
and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium
Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes,” European
Journal of Organic Chemistry, vol. 27, no. 8, 2024, doi: 10.1002/ejoc.202301207.'
mla: Peschtrich, Sebastian, et al. “A Comparative Kinetic and Computational Investigation
of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene
Using Palladium/Bisphosphine Complexes.” European Journal of Organic Chemistry,
vol. 27, no. 8, Wiley, 2024, doi:10.1002/ejoc.202301207.
short: S. Peschtrich, R. Schoch, D. Kuckling, J. Paradies, European Journal of Organic
Chemistry 27 (2024).
date_created: 2024-03-13T17:15:14Z
date_updated: 2024-03-13T17:17:37Z
department:
- _id: '2'
- _id: '389'
doi: 10.1002/ejoc.202301207
intvolume: ' 27'
issue: '8'
keyword:
- Organic Chemistry
- Physical and Theoretical Chemistry
language:
- iso: eng
publication: European Journal of Organic Chemistry
publication_identifier:
issn:
- 1434-193X
- 1099-0690
publication_status: published
publisher: Wiley
status: public
title: A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur
Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine
Complexes
type: journal_article
user_id: '53339'
volume: 27
year: '2024'
...
---
_id: '53163'
abstract:
- lang: eng
text: An SPR-based dually crosslinked gel sensor for adiponitrile bearing
pillar[5]arene responsive sites with a low limit of detection was developed.
article_type: original
author:
- first_name: Maksim
full_name: Rodin, Maksim
last_name: Rodin
- first_name: David
full_name: Helle, David
last_name: Helle
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Rodin M, Helle D, Kuckling D. Pillar[5]arene-based dually crosslinked supramolecular
gel as a sensor for the detection of adiponitrile. Polymer Chemistry. 2024;15(7):661-679.
doi:10.1039/d3py01354e
apa: Rodin, M., Helle, D., & Kuckling, D. (2024). Pillar[5]arene-based dually
crosslinked supramolecular gel as a sensor for the detection of adiponitrile.
Polymer Chemistry, 15(7), 661–679. https://doi.org/10.1039/d3py01354e
bibtex: '@article{Rodin_Helle_Kuckling_2024, title={Pillar[5]arene-based dually
crosslinked supramolecular gel as a sensor for the detection of adiponitrile},
volume={15}, DOI={10.1039/d3py01354e},
number={7}, journal={Polymer Chemistry}, publisher={Royal Society of Chemistry
(RSC)}, author={Rodin, Maksim and Helle, David and Kuckling, Dirk}, year={2024},
pages={661–679} }'
chicago: 'Rodin, Maksim, David Helle, and Dirk Kuckling. “Pillar[5]Arene-Based Dually
Crosslinked Supramolecular Gel as a Sensor for the Detection of Adiponitrile.”
Polymer Chemistry 15, no. 7 (2024): 661–79. https://doi.org/10.1039/d3py01354e.'
ieee: 'M. Rodin, D. Helle, and D. Kuckling, “Pillar[5]arene-based dually crosslinked
supramolecular gel as a sensor for the detection of adiponitrile,” Polymer
Chemistry, vol. 15, no. 7, pp. 661–679, 2024, doi: 10.1039/d3py01354e.'
mla: Rodin, Maksim, et al. “Pillar[5]Arene-Based Dually Crosslinked Supramolecular
Gel as a Sensor for the Detection of Adiponitrile.” Polymer Chemistry,
vol. 15, no. 7, Royal Society of Chemistry (RSC), 2024, pp. 661–79, doi:10.1039/d3py01354e.
short: M. Rodin, D. Helle, D. Kuckling, Polymer Chemistry 15 (2024) 661–679.
date_created: 2024-04-03T10:57:17Z
date_updated: 2024-04-03T11:03:03Z
department:
- _id: '163'
doi: 10.1039/d3py01354e
intvolume: ' 15'
issue: '7'
keyword:
- Organic Chemistry
- Polymers and Plastics
- Biochemistry
- Bioengineering
language:
- iso: eng
page: 661-679
publication: Polymer Chemistry
publication_identifier:
issn:
- 1759-9954
- 1759-9962
publication_status: published
publisher: Royal Society of Chemistry (RSC)
status: public
title: Pillar[5]arene-based dually crosslinked supramolecular gel as a sensor for
the detection of adiponitrile
type: journal_article
user_id: '94'
volume: 15
year: '2024'
...
---
_id: '59509'
abstract:
- lang: eng
text: AbstractA strategy for multifunctional biosurfaces
exploiting multiblock copolymers and the antipolyelectrolyte effect is reported.
Combining a polyzwitterionic/antifouling and a polycationic/antibacterial block
with a central anchoring block for attachment to titanium oxide surfaces affords
surface coatings that exhibit antifouling properties against proteins and allow
for surface regeneration by clearing adhering proteins by employing a salt washing
step. The surfaces also kill bacteria by contact killing, which is aided by a
nonfouling block. The synthesis of block copolymers of 4‐vinyl pyridine (VP),
dimethyl 4‐vinylbenzyl phosphonate (DMVBP), and 4‐vinylbenzyltrimethyl ammonium
chloride (TMA) is achieved on the multigram scale via RAFT polymerization with
good end group retention and narrow dispersities. By polymer analogous reactions,
poly(4‐vinyl pyridinium propane sulfonate‐block‐4‐vinylbenzyl
phosphonic acid‐block‐4‐vinylbenzyl trimethylammonium
chloride) (P(VSP64‐b‐PA14‐b‐TMA64))
is obtained. The antifouling properties against the model protein pepsin and the
salt‐induced surface regeneration are shown in surface plasmon resonance (SPR)
experiments, while independently the antibacterial and antifouling properties
of coated titanium substrates are successfully tested in preliminary microbiological
assays against Staphylococcus aureus (S.
aureus) and Escherichia coli (E.
coli). This strategy may contribute to the development of long‐term
effective antibacterial implant surface coatings to suppress biomedical device‐associated
infections.
author:
- first_name: Rafael
full_name: Methling, Rafael
last_name: Methling
- first_name: Michael
full_name: Greiter, Michael
last_name: Greiter
- first_name: Jiwar
full_name: Al‐Zawity, Jiwar
last_name: Al‐Zawity
- first_name: Mareike
full_name: Müller, Mareike
last_name: Müller
- first_name: Holger
full_name: Schönherr, Holger
last_name: Schönherr
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Methling R, Greiter M, Al‐Zawity J, Müller M, Schönherr H, Kuckling D. Salt‐Responsive
Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.
Macromolecular Bioscience. 2024;25(1). doi:10.1002/mabi.202400261
apa: Methling, R., Greiter, M., Al‐Zawity, J., Müller, M., Schönherr, H., &
Kuckling, D. (2024). Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial
and Antifouling Properties. Macromolecular Bioscience, 25(1). https://doi.org/10.1002/mabi.202400261
bibtex: '@article{Methling_Greiter_Al‐Zawity_Müller_Schönherr_Kuckling_2024, title={Salt‐Responsive
Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties},
volume={25}, DOI={10.1002/mabi.202400261},
number={1}, journal={Macromolecular Bioscience}, publisher={Wiley}, author={Methling,
Rafael and Greiter, Michael and Al‐Zawity, Jiwar and Müller, Mareike and Schönherr,
Holger and Kuckling, Dirk}, year={2024} }'
chicago: Methling, Rafael, Michael Greiter, Jiwar Al‐Zawity, Mareike Müller, Holger
Schönherr, and Dirk Kuckling. “Salt‐Responsive Switchable Block Copolymer Brushes
with Antibacterial and Antifouling Properties.” Macromolecular Bioscience
25, no. 1 (2024). https://doi.org/10.1002/mabi.202400261.
ieee: 'R. Methling, M. Greiter, J. Al‐Zawity, M. Müller, H. Schönherr, and D. Kuckling,
“Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling
Properties,” Macromolecular Bioscience, vol. 25, no. 1, 2024, doi: 10.1002/mabi.202400261.'
mla: Methling, Rafael, et al. “Salt‐Responsive Switchable Block Copolymer Brushes
with Antibacterial and Antifouling Properties.” Macromolecular Bioscience,
vol. 25, no. 1, Wiley, 2024, doi:10.1002/mabi.202400261.
short: R. Methling, M. Greiter, J. Al‐Zawity, M. Müller, H. Schönherr, D. Kuckling,
Macromolecular Bioscience 25 (2024).
date_created: 2025-04-11T07:07:31Z
date_updated: 2025-04-11T07:09:03Z
department:
- _id: '163'
doi: 10.1002/mabi.202400261
intvolume: ' 25'
issue: '1'
keyword:
- antibacterial coatings
- antipolyelectrolyte effect
- salt switchable polymers
- zwitterionic brushes
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400261
publication: Macromolecular Bioscience
publication_identifier:
issn:
- 1616-5187
- 1616-5195
publication_status: published
publisher: Wiley
status: public
title: Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling
Properties
type: journal_article
user_id: '94'
volume: 25
year: '2024'
...
---
_id: '59508'
abstract:
- lang: eng
text: Over the last few decades, nanotechnology has established to be a promising
field in medicine. A remaining dominant challenge in today's pharmacotherapy is
the limited selectivity of active pharmaceutical ingredients and associated undesirable
side effects. Controlled drug release can be promoted by smart drug delivery systems,
which release embedded API primarily depending on specific stimuli. Consequently,
also the microenvironment of tumor tissue can be used advantageously. Dithiothreitol
(DTT) based self-immolative polydisulfides were synthesized that preferentially
respond to pathologically increased glutathione (GSH) concentrations, as found
in solid tumors. The synthesis with different degrees of polymerisation was investigated
as well as the synthesis of a copolymer consisting of dithiothreitol and butanedithiol
(BDT). Toxicity tests were carried out on pure polymers and their degradation
products. The ability to degrade was examined at pathological and physiological
glutathione concentrations in order to test the suitability of the polymer as
a matrix for nanoparticulate carrier systems. In addition, the processability
of one polymer into nanoparticles was investigated as well as the degradation
behaviour with glutathione.
article_type: original
author:
- first_name: Katharina
full_name: Völlmecke, Katharina
last_name: Völlmecke
- first_name: Maurice
full_name: Kramer, Maurice
last_name: Kramer
- first_name: Corinna
full_name: Horky, Corinna
last_name: Horky
- first_name: Oliver
full_name: Dückmann, Oliver
last_name: Dückmann
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Völlmecke K, Kramer M, Horky C, et al. Self-immolative polydisulfides and their
use as nanoparticles for drug delivery systems. RSC Advances. 2024;14(48):35568-35577.
doi:10.1039/d4ra07228f
apa: Völlmecke, K., Kramer, M., Horky, C., Dückmann, O., Mulac, D., Langer, K.,
& Kuckling, D. (2024). Self-immolative polydisulfides and their use as nanoparticles
for drug delivery systems. RSC Advances, 14(48), 35568–35577. https://doi.org/10.1039/d4ra07228f
bibtex: '@article{Völlmecke_Kramer_Horky_Dückmann_Mulac_Langer_Kuckling_2024, title={Self-immolative
polydisulfides and their use as nanoparticles for drug delivery systems}, volume={14},
DOI={10.1039/d4ra07228f}, number={48},
journal={RSC Advances}, publisher={Royal Society of Chemistry (RSC)}, author={Völlmecke,
Katharina and Kramer, Maurice and Horky, Corinna and Dückmann, Oliver and Mulac,
Dennis and Langer, Klaus and Kuckling, Dirk}, year={2024}, pages={35568–35577}
}'
chicago: 'Völlmecke, Katharina, Maurice Kramer, Corinna Horky, Oliver Dückmann,
Dennis Mulac, Klaus Langer, and Dirk Kuckling. “Self-Immolative Polydisulfides
and Their Use as Nanoparticles for Drug Delivery Systems.” RSC Advances
14, no. 48 (2024): 35568–77. https://doi.org/10.1039/d4ra07228f.'
ieee: 'K. Völlmecke et al., “Self-immolative polydisulfides and their use
as nanoparticles for drug delivery systems,” RSC Advances, vol. 14, no.
48, pp. 35568–35577, 2024, doi: 10.1039/d4ra07228f.'
mla: Völlmecke, Katharina, et al. “Self-Immolative Polydisulfides and Their Use
as Nanoparticles for Drug Delivery Systems.” RSC Advances, vol. 14, no.
48, Royal Society of Chemistry (RSC), 2024, pp. 35568–77, doi:10.1039/d4ra07228f.
short: K. Völlmecke, M. Kramer, C. Horky, O. Dückmann, D. Mulac, K. Langer, D. Kuckling,
RSC Advances 14 (2024) 35568–35577.
date_created: 2025-04-11T07:03:03Z
date_updated: 2025-04-11T07:06:22Z
department:
- _id: '163'
doi: 10.1039/d4ra07228f
intvolume: ' 14'
issue: '48'
language:
- iso: eng
main_file_link:
- url: https://pubs.rsc.org/en/content/articlelanding/2024/ra/d4ra07228f
page: 35568-35577
publication: RSC Advances
publication_identifier:
issn:
- 2046-2069
publication_status: published
publisher: Royal Society of Chemistry (RSC)
status: public
title: Self-immolative polydisulfides and their use as nanoparticles for drug delivery
systems
type: journal_article
user_id: '94'
volume: 14
year: '2024'
...
---
_id: '35657'
abstract:
- lang: eng
text: The controlled delivery of active pharmaceutical ingredients to the site of
disease represents a major challenge in drug therapy. Particularly when drugs
have to be transported across biological barriers, suitable drug delivery systems
are of importance. In recent years responsive delivery systems have been developed
which enable a controlled drug release depending on internal or external stimuli
such as changes in pH, redox environment or light and temperature. In some studies
delivery systems with reactivity against two different stimuli were established
either to enhance the response by synergies of the stimuli or to broaden the window
of possible trigger events. In the present review numerous exciting developments
of pH-, light- and redox-cleavable polymers suitable for the preparation of smart
delivery systems are described. The review discusses the different stimuli that
can be used for a controlled drug release of polymer-based delivery systems. It
puts a focus on the different polymers described for the preparation of stimuli-sensitive
systems, their preparation techniques as well as their stimuli-responsive degradation.
© 2022 The Authors. Polymer International published by John Wiley & Sons Ltd on
behalf of Society of Industrial Chemistry.
article_type: original
author:
- first_name: Tarik
full_name: Rust, Tarik
last_name: Rust
- first_name: Dimitri
full_name: Jung, Dimitri
last_name: Jung
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Rust T, Jung D, Langer K, Kuckling D. Stimuli‐accelerated polymeric drug delivery
systems. Polymer International. 2023;72(1):5-19. doi:10.1002/pi.6474
apa: Rust, T., Jung, D., Langer, K., & Kuckling, D. (2023). Stimuli‐accelerated
polymeric drug delivery systems. Polymer International, 72(1), 5–19.
https://doi.org/10.1002/pi.6474
bibtex: '@article{Rust_Jung_Langer_Kuckling_2023, title={Stimuli‐accelerated polymeric
drug delivery systems}, volume={72}, DOI={10.1002/pi.6474},
number={1}, journal={Polymer International}, publisher={Wiley}, author={Rust,
Tarik and Jung, Dimitri and Langer, Klaus and Kuckling, Dirk}, year={2023}, pages={5–19}
}'
chicago: 'Rust, Tarik, Dimitri Jung, Klaus Langer, and Dirk Kuckling. “Stimuli‐accelerated
Polymeric Drug Delivery Systems.” Polymer International 72, no. 1 (2023):
5–19. https://doi.org/10.1002/pi.6474.'
ieee: 'T. Rust, D. Jung, K. Langer, and D. Kuckling, “Stimuli‐accelerated polymeric
drug delivery systems,” Polymer International, vol. 72, no. 1, pp. 5–19,
2023, doi: 10.1002/pi.6474.'
mla: Rust, Tarik, et al. “Stimuli‐accelerated Polymeric Drug Delivery Systems.”
Polymer International, vol. 72, no. 1, Wiley, 2023, pp. 5–19, doi:10.1002/pi.6474.
short: T. Rust, D. Jung, K. Langer, D. Kuckling, Polymer International 72 (2023)
5–19.
date_created: 2023-01-10T08:25:22Z
date_updated: 2023-01-10T08:31:31Z
department:
- _id: '163'
doi: 10.1002/pi.6474
intvolume: ' 72'
issue: '1'
keyword:
- drug delivery system
- stimuli
- polymer
- cleavable
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/pi.6474
page: 5-19
publication: Polymer International
publication_identifier:
issn:
- 0959-8103
- 1097-0126
publication_status: published
publisher: Wiley
status: public
title: Stimuli‐accelerated polymeric drug delivery systems
type: journal_article
user_id: '94'
volume: 72
year: '2023'
...
---
_id: '53170'
abstract:
- lang: eng
text: AbstractCoating medical implants with antibacterial
polymers may prevent postoperative infections which are a common issue for conventional
titanium implants and can even lead to implant failure. Easily applicable diblock
copolymers are presented that form polymer brushes via “grafting to” mechanism
on titanium and equip the modified material with antibacterial properties. The
polymers carry quaternized pyridinium units to combat bacteria and phosphonic
acid groups which allow the linear chains to be anchored to metal surfaces in
a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer
(RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy
and SEC. Low grafting densities are a major drawback of the “grafting to” approach
compared to “grafting from”. Thus, the number of phosphonic acid groups in the
anchor block are varied to investigate and optimize the surface binding. Modified
titanium surfaces are examined regarding their composition, wetting behavior,
streaming potential, and coating stability. Evaluation of the antimicrobial properties
revealed reduced bacterial adhesion and biofilm formation for certain polymers,
albeit the cell biocompatibility against human gingival fibroblasts is also impaired.
The presented findings show the potential of easy‐to‐apply polymer coatings and
aid in designing next‐generation implant surface modifications.
article_type: original
author:
- first_name: Rafael
full_name: Methling, Rafael
last_name: Methling
- first_name: Oliver
full_name: Dückmann, Oliver
last_name: Dückmann
- first_name: Frank
full_name: Simon, Frank
last_name: Simon
- first_name: Cornelia
full_name: Wolf‐Brandstetter, Cornelia
last_name: Wolf‐Brandstetter
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Methling R, Dückmann O, Simon F, Wolf‐Brandstetter C, Kuckling D. Antimicrobial
Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing
Block Copolymers. Macromolecular Materials and Engineering. 2023;308(8).
doi:10.1002/mame.202200665
apa: Methling, R., Dückmann, O., Simon, F., Wolf‐Brandstetter, C., & Kuckling,
D. (2023). Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic
Acid/Pyridinium Containing Block Copolymers. Macromolecular Materials and Engineering,
308(8). https://doi.org/10.1002/mame.202200665
bibtex: '@article{Methling_Dückmann_Simon_Wolf‐Brandstetter_Kuckling_2023, title={Antimicrobial
Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing
Block Copolymers}, volume={308}, DOI={10.1002/mame.202200665},
number={8}, journal={Macromolecular Materials and Engineering}, publisher={Wiley},
author={Methling, Rafael and Dückmann, Oliver and Simon, Frank and Wolf‐Brandstetter,
Cornelia and Kuckling, Dirk}, year={2023} }'
chicago: Methling, Rafael, Oliver Dückmann, Frank Simon, Cornelia Wolf‐Brandstetter,
and Dirk Kuckling. “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using
Phosphonic Acid/Pyridinium Containing Block Copolymers.” Macromolecular Materials
and Engineering 308, no. 8 (2023). https://doi.org/10.1002/mame.202200665.
ieee: 'R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, and D. Kuckling,
“Antimicrobial Brushes on Titanium via ‘Grafting to’ Using Phosphonic Acid/Pyridinium
Containing Block Copolymers,” Macromolecular Materials and Engineering,
vol. 308, no. 8, 2023, doi: 10.1002/mame.202200665.'
mla: Methling, Rafael, et al. “Antimicrobial Brushes on Titanium via ‘Grafting to’
Using Phosphonic Acid/Pyridinium Containing Block Copolymers.” Macromolecular
Materials and Engineering, vol. 308, no. 8, Wiley, 2023, doi:10.1002/mame.202200665.
short: R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, D. Kuckling, Macromolecular
Materials and Engineering 308 (2023).
date_created: 2024-04-03T11:08:51Z
date_updated: 2024-04-03T11:10:05Z
department:
- _id: '163'
doi: 10.1002/mame.202200665
intvolume: ' 308'
issue: '8'
keyword:
- Materials Chemistry
- Polymers and Plastics
- Organic Chemistry
- General Chemical Engineering
language:
- iso: eng
publication: Macromolecular Materials and Engineering
publication_identifier:
issn:
- 1438-7492
- 1439-2054
publication_status: published
publisher: Wiley
status: public
title: Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium
Containing Block Copolymers
type: journal_article
user_id: '94'
volume: 308
year: '2023'
...
---
_id: '53166'
abstract:
- lang: eng
text: The Knoevenagel reaction is a classic reaction in organic chemistry
for the formation of C-C bonds. In this study, various catalytic monomers for
Knoevenagel reactions were synthesized and polymerized via photolithography to
form polymeric gel dots with a composition of 90% catalyst, 9% gelling agent and
1% crosslinker. Furthermore, these gel dots were inserted into a microfluidic
reactor (MFR) and the conversion of the reaction using gel dots as catalysts in
the MFR for 8 h at room temperature was studied. The gel dots containing primary
amines showed a better conversion of about 83–90% with aliphatic aldehyde and
86–100% with aromatic aldehyde, compared to the tertiary amines (52–59% with aliphatic
aldehyde and 77–93% with aromatic aldehydes) which resembles the reactivity of
the amines. Moreover, the addition of polar solvent (water) in the reaction mixture
and the swelling properties of the gel dots by altering the polymer backbone showed
a significant enhancement in the conversion of the reaction, due to the increased
accessibility of the catalytic sites in the polymeric network. These results suggested
the primary-amine-based catalysts facilitate better conversion compared to tertiary
amines and the reaction solvent had a significant influence on organocatalysis
to improve the efficiency of MFR.
article_number: '171'
article_type: original
author:
- first_name: Naresh
full_name: Killi, Naresh
last_name: Killi
- first_name: Julian
full_name: Bartenbach, Julian
last_name: Bartenbach
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Killi N, Bartenbach J, Kuckling D. Polymeric Networks Containing Amine Derivatives
as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic
Reactors. Gels. 2023;9(3). doi:10.3390/gels9030171
apa: Killi, N., Bartenbach, J., & Kuckling, D. (2023). Polymeric Networks Containing
Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously
Driven Microfluidic Reactors. Gels, 9(3), Article 171. https://doi.org/10.3390/gels9030171
bibtex: '@article{Killi_Bartenbach_Kuckling_2023, title={Polymeric Networks Containing
Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously
Driven Microfluidic Reactors}, volume={9}, DOI={10.3390/gels9030171},
number={3171}, journal={Gels}, publisher={MDPI AG}, author={Killi, Naresh and
Bartenbach, Julian and Kuckling, Dirk}, year={2023} }'
chicago: Killi, Naresh, Julian Bartenbach, and Dirk Kuckling. “Polymeric Networks
Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within
Continuously Driven Microfluidic Reactors.” Gels 9, no. 3 (2023). https://doi.org/10.3390/gels9030171.
ieee: 'N. Killi, J. Bartenbach, and D. Kuckling, “Polymeric Networks Containing
Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously
Driven Microfluidic Reactors,” Gels, vol. 9, no. 3, Art. no. 171, 2023,
doi: 10.3390/gels9030171.'
mla: Killi, Naresh, et al. “Polymeric Networks Containing Amine Derivatives as Organocatalysts
for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors.” Gels,
vol. 9, no. 3, 171, MDPI AG, 2023, doi:10.3390/gels9030171.
short: N. Killi, J. Bartenbach, D. Kuckling, Gels 9 (2023).
date_created: 2024-04-03T11:06:26Z
date_updated: 2024-04-03T11:07:31Z
department:
- _id: '163'
doi: 10.3390/gels9030171
intvolume: ' 9'
issue: '3'
keyword:
- Knoevenagel reaction
- organocatalysis
- polymeric gel dots
- microfluidic reactions
- polymeric networks
language:
- iso: eng
publication: Gels
publication_identifier:
issn:
- 2310-2861
publication_status: published
publisher: MDPI AG
status: public
title: Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel
Reaction within Continuously Driven Microfluidic Reactors
type: journal_article
user_id: '94'
volume: 9
year: '2023'
...
---
_id: '35642'
abstract:
- lang: eng
text: 'There is an increasing interest in sensing applications for a variety
of analytes in aqueous environments, as conventional methods do not work reliably
under humid conditions or they require complex equipment with experienced operators.
Hydrogel sensors are easy to fabricate, are incredibly sensitive, and have broad
dynamic ranges. Experiments on their robustness, reliability, and reusability
have indicated the possible long-term applications of these systems in a variety
of fields, including disease diagnosis, detection of pharmaceuticals, and in environmental
testing. It is possible to produce hydrogels, which, upon sensing a specific analyte,
can adsorb it onto their 3D-structure and can therefore be used to remove them
from a given environment. High specificity can be obtained by using molecularly
imprinted polymers. Typical detection principles involve optical methods including
fluorescence and chemiluminescence, and volume changes in colloidal photonic crystals,
as well as electrochemical methods. Here, we explore the current research utilizing
hydrogel-based sensors in three main areas: (1) biomedical applications, (2) for
detecting and quantifying pharmaceuticals of interest, and (3) detecting and quantifying
environmental contaminants in aqueous environments.'
article_number: '768'
article_type: review
author:
- first_name: Katharina
full_name: Völlmecke, Katharina
last_name: Völlmecke
- first_name: Rowshon
full_name: Afroz, Rowshon
last_name: Afroz
- first_name: Sascha
full_name: Bierbach, Sascha
last_name: Bierbach
- first_name: Lee Josephine
full_name: Brenker, Lee Josephine
last_name: Brenker
- first_name: Sebastian
full_name: Frücht, Sebastian
last_name: Frücht
- first_name: Alexandra
full_name: Glass, Alexandra
last_name: Glass
- first_name: Ryland
full_name: Giebelhaus, Ryland
last_name: Giebelhaus
- first_name: Axel
full_name: Hoppe, Axel
last_name: Hoppe
- first_name: Karen
full_name: Kanemaru, Karen
last_name: Kanemaru
- first_name: Michal
full_name: Lazarek, Michal
last_name: Lazarek
- first_name: Lukas
full_name: Rabbe, Lukas
last_name: Rabbe
- first_name: Longfei
full_name: Song, Longfei
last_name: Song
- first_name: Andrea
full_name: Velasco Suarez, Andrea
last_name: Velasco Suarez
- first_name: Shuang
full_name: Wu, Shuang
last_name: Wu
- first_name: Michael
full_name: Serpe, Michael
last_name: Serpe
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Völlmecke K, Afroz R, Bierbach S, et al. Hydrogel-Based Biosensors. Gels.
2022;8(12). doi:10.3390/gels8120768
apa: Völlmecke, K., Afroz, R., Bierbach, S., Brenker, L. J., Frücht, S., Glass,
A., Giebelhaus, R., Hoppe, A., Kanemaru, K., Lazarek, M., Rabbe, L., Song, L.,
Velasco Suarez, A., Wu, S., Serpe, M., & Kuckling, D. (2022). Hydrogel-Based
Biosensors. Gels, 8(12), Article 768. https://doi.org/10.3390/gels8120768
bibtex: '@article{Völlmecke_Afroz_Bierbach_Brenker_Frücht_Glass_Giebelhaus_Hoppe_Kanemaru_Lazarek_et
al._2022, title={Hydrogel-Based Biosensors}, volume={8}, DOI={10.3390/gels8120768},
number={12768}, journal={Gels}, publisher={MDPI AG}, author={Völlmecke, Katharina
and Afroz, Rowshon and Bierbach, Sascha and Brenker, Lee Josephine and Frücht,
Sebastian and Glass, Alexandra and Giebelhaus, Ryland and Hoppe, Axel and Kanemaru,
Karen and Lazarek, Michal and et al.}, year={2022} }'
chicago: Völlmecke, Katharina, Rowshon Afroz, Sascha Bierbach, Lee Josephine Brenker,
Sebastian Frücht, Alexandra Glass, Ryland Giebelhaus, et al. “Hydrogel-Based Biosensors.”
Gels 8, no. 12 (2022). https://doi.org/10.3390/gels8120768.
ieee: 'K. Völlmecke et al., “Hydrogel-Based Biosensors,” Gels, vol.
8, no. 12, Art. no. 768, 2022, doi: 10.3390/gels8120768.'
mla: Völlmecke, Katharina, et al. “Hydrogel-Based Biosensors.” Gels, vol.
8, no. 12, 768, MDPI AG, 2022, doi:10.3390/gels8120768.
short: K. Völlmecke, R. Afroz, S. Bierbach, L.J. Brenker, S. Frücht, A. Glass, R.
Giebelhaus, A. Hoppe, K. Kanemaru, M. Lazarek, L. Rabbe, L. Song, A. Velasco Suarez,
S. Wu, M. Serpe, D. Kuckling, Gels 8 (2022).
date_created: 2023-01-10T08:02:50Z
date_updated: 2023-01-10T08:05:30Z
department:
- _id: '163'
doi: 10.3390/gels8120768
intvolume: ' 8'
issue: '12'
keyword:
- Polymers and Plastics
- Organic Chemistry
- Biomaterials
- Bioengineering
language:
- iso: eng
main_file_link:
- url: https://www.mdpi.com/2310-2861/8/12/768
publication: Gels
publication_identifier:
issn:
- 2310-2861
publication_status: published
publisher: MDPI AG
status: public
title: Hydrogel-Based Biosensors
type: journal_article
user_id: '94'
volume: 8
year: '2022'
...
---
_id: '32416'
abstract:
- lang: eng
text: In recent years, sequence-defined oligomers (SDOs) gained increasing interest
due to their perfectly controlled molecular structure, thus providing defined
properties. In order to tune the properties, different functionalities need to
be incorporated into the oligomers and the chain tacticity needs to be controlled.
Beside the synthesis of SDOs, suitable methods need to be found to analyze the
molecular structure. In this work, oligomers exhibiting an alternating or block-wise
sequence of side chain functionalities were analyzed using a hyphenation of ultra-high-performance
liquid chromatography and electrospray ionization mass spectrometry enhanced by
ion mobility separation (IMS). Moieties in the side chains were varied according
to polarity and bulkiness. Moreover, chain tacticity was varied. Drift times in
the IMS cell and the corresponding collision cross section (CCS) values were shown
to be individual parameters allowing the identification of SDOs, even in the case
that SDO structures only differ in sequence or tacticity of side chain functionalities.
Thus, a library of CCS values was obtained as reference used for the analysis
of complex mixtures of SDOs.
article_type: original
author:
- first_name: Marie-Theres
full_name: Berg, Marie-Theres
last_name: Berg
- first_name: Artjom
full_name: Herberg, Artjom
id: '94'
last_name: Herberg
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Berg M-T, Herberg A, Kuckling D. Hyphenation of ultra-high-performance liquid
chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
oligomers with different functionalities and tacticity. International Journal
of Polymer Analysis and Characterization. Published online 2022:1-12. doi:10.1080/1023666x.2022.2100968
apa: Berg, M.-T., Herberg, A., & Kuckling, D. (2022). Hyphenation of ultra-high-performance
liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
oligomers with different functionalities and tacticity. International Journal
of Polymer Analysis and Characterization, 1–12. https://doi.org/10.1080/1023666x.2022.2100968
bibtex: '@article{Berg_Herberg_Kuckling_2022, title={Hyphenation of ultra-high-performance
liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
oligomers with different functionalities and tacticity}, DOI={10.1080/1023666x.2022.2100968},
journal={International Journal of Polymer Analysis and Characterization}, publisher={Informa
UK Limited}, author={Berg, Marie-Theres and Herberg, Artjom and Kuckling, Dirk},
year={2022}, pages={1–12} }'
chicago: Berg, Marie-Theres, Artjom Herberg, and Dirk Kuckling. “Hyphenation of
Ultra-High-Performance Liquid Chromatography and Ion Mobility Mass Spectrometry
for the Analysis of Sequence-Defined Oligomers with Different Functionalities
and Tacticity.” International Journal of Polymer Analysis and Characterization,
2022, 1–12. https://doi.org/10.1080/1023666x.2022.2100968.
ieee: 'M.-T. Berg, A. Herberg, and D. Kuckling, “Hyphenation of ultra-high-performance
liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
oligomers with different functionalities and tacticity,” International Journal
of Polymer Analysis and Characterization, pp. 1–12, 2022, doi: 10.1080/1023666x.2022.2100968.'
mla: Berg, Marie-Theres, et al. “Hyphenation of Ultra-High-Performance Liquid Chromatography
and Ion Mobility Mass Spectrometry for the Analysis of Sequence-Defined Oligomers
with Different Functionalities and Tacticity.” International Journal of Polymer
Analysis and Characterization, Informa UK Limited, 2022, pp. 1–12, doi:10.1080/1023666x.2022.2100968.
short: M.-T. Berg, A. Herberg, D. Kuckling, International Journal of Polymer Analysis
and Characterization (2022) 1–12.
date_created: 2022-07-26T06:38:52Z
date_updated: 2023-01-10T08:14:52Z
department:
- _id: '163'
doi: 10.1080/1023666x.2022.2100968
keyword:
- Ultra-high-performance liquid chromatography
- ion mobility separation
- mass spectrometry
- LC-MS hyphenation
- sequence-defined oligomers
language:
- iso: eng
page: 1-12
publication: International Journal of Polymer Analysis and Characterization
publication_identifier:
issn:
- 1023-666X
- 1563-5341
publication_status: published
publisher: Informa UK Limited
status: public
title: Hyphenation of ultra-high-performance liquid chromatography and ion mobility
mass spectrometry for the analysis of sequence-defined oligomers with different
functionalities and tacticity
type: journal_article
user_id: '94'
year: '2022'
...
---
_id: '35645'
abstract:
- lang: eng
text: Poly(quinuclidin-3-yl methacrylate-co-divinylbenzene) microparticles having
porous as well as nonporous morphology and varying contents of quinuclidine functionality
were synthesized by distillation–precipitation polymerization. Further, the synthesized
microparticles were explored to catalyze the Baylis–Hillman reaction between 4-nitrobenzaldehyde
and acrylonitrile. Porous and nonporous microparticles functionalized with a catalytic
moiety with a loading of 70% (labeled as P70 and NP70) were employed to optimize
reaction parameters such as water content, solvent, and temperature for the Baylis–Hillman
reaction between 4-nitrobenzaldehyde and acrylonitrile. Using optimal conditions,
the catalytic efficiency of porous and nonporous microparticles at different feed
compositions was determined. Porous microparticles containing 70% of quinuclidine
(P70) displayed 100% conversion within 16 h at 50 °C, while nonporous microparticles
containing 70% of quinuclidine (NP70) displayed a relatively less catalytic conversion,
which is attributed to their lower surface area. Furthermore, the catalytic activity
of porous microparticles containing 70% of quinuclidine (P70) for the Baylis–Hillman
reaction involving a variety of aryl aldehyde derivatives was determined, where
the microparticles displayed impressive catalytic efficiency. In addition, the
reusability of the microparticles functionalized with a catalytic moiety was evaluated
for five cycles of catalytic reaction.
article_type: original
author:
- first_name: Amit
full_name: Kumar, Amit
last_name: Kumar
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Leena
full_name: Nebhani, Leena
last_name: Nebhani
citation:
ama: Kumar A, Kuckling D, Nebhani L. Quinuclidine-Immobilized Porous Polymeric Microparticles
as a Compelling Catalyst for the Baylis–Hillman Reaction. ACS Applied Polymer
Materials. 2022;4(12):8996-9005. doi:10.1021/acsapm.2c01330
apa: Kumar, A., Kuckling, D., & Nebhani, L. (2022). Quinuclidine-Immobilized
Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman
Reaction. ACS Applied Polymer Materials, 4(12), 8996–9005. https://doi.org/10.1021/acsapm.2c01330
bibtex: '@article{Kumar_Kuckling_Nebhani_2022, title={Quinuclidine-Immobilized Porous
Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction},
volume={4}, DOI={10.1021/acsapm.2c01330},
number={12}, journal={ACS Applied Polymer Materials}, publisher={American Chemical
Society (ACS)}, author={Kumar, Amit and Kuckling, Dirk and Nebhani, Leena}, year={2022},
pages={8996–9005} }'
chicago: 'Kumar, Amit, Dirk Kuckling, and Leena Nebhani. “Quinuclidine-Immobilized
Porous Polymeric Microparticles as a Compelling Catalyst for the Baylis–Hillman
Reaction.” ACS Applied Polymer Materials 4, no. 12 (2022): 8996–9005. https://doi.org/10.1021/acsapm.2c01330.'
ieee: 'A. Kumar, D. Kuckling, and L. Nebhani, “Quinuclidine-Immobilized Porous Polymeric
Microparticles as a Compelling Catalyst for the Baylis–Hillman Reaction,” ACS
Applied Polymer Materials, vol. 4, no. 12, pp. 8996–9005, 2022, doi: 10.1021/acsapm.2c01330.'
mla: Kumar, Amit, et al. “Quinuclidine-Immobilized Porous Polymeric Microparticles
as a Compelling Catalyst for the Baylis–Hillman Reaction.” ACS Applied Polymer
Materials, vol. 4, no. 12, American Chemical Society (ACS), 2022, pp. 8996–9005,
doi:10.1021/acsapm.2c01330.
short: A. Kumar, D. Kuckling, L. Nebhani, ACS Applied Polymer Materials 4 (2022)
8996–9005.
date_created: 2023-01-10T08:07:12Z
date_updated: 2023-01-10T08:12:15Z
department:
- _id: '163'
doi: 10.1021/acsapm.2c01330
intvolume: ' 4'
issue: '12'
keyword:
- distillation−precipitation polymerization
- porous microparticles
- heterogeneous catalysis Baylis−Hillman reaction
- reusable catalyst
language:
- iso: eng
main_file_link:
- url: https://pubs.acs.org/doi/10.1021/acsapm.2c01330
page: 8996-9005
publication: ACS Applied Polymer Materials
publication_identifier:
issn:
- 2637-6105
- 2637-6105
publication_status: published
publisher: American Chemical Society (ACS)
status: public
title: Quinuclidine-Immobilized Porous Polymeric Microparticles as a Compelling Catalyst
for the Baylis–Hillman Reaction
type: journal_article
user_id: '94'
volume: 4
year: '2022'
...
---
_id: '32865'
abstract:
- lang: eng
text: For the first time, poly(N-isopropylacrylamide) (PNIPAAm) star polymers with
a β-cyclodextrin core are characterized in detail by size-exclusion chromatography
(SEC) with triple detection to experimentally verify the number of arms. A combination
of a refractive index detector, multi-angle laser light scattering detector, and
an online-viscosimeter was used for branching analysis. At first, the SEC system
was calibrated and the detector setup was validated using linear polystyrene reference
polymers. The applicability of the established triple detection SEC for branching
analysis was shown by the analysis of two commercially available polystyrene star
polymers. Due to the high molar masses of the star polymers, both the contraction
ratio g and g′ could be determined independently, thus allowing the calculation
of the viscosity shielding ratio ε. Finally, the branching analysis of the PNIPAAm
star polymers could experimentally confirm the assumed arm number of up to 21
arms. Moreover, an increasingly compact molecular structure and the influence
of the arm number on the viscosity shielding ratio could be shown.
author:
- first_name: Artjom
full_name: Herberg, Artjom
id: '94'
last_name: Herberg
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Herberg A, Kuckling D. Branching analysis of β-cyclodextrin-based poly(N-isopropylacrylamide)
star polymers using triple detection SEC. International Journal of Polymer
Analysis and Characterization. Published online 2022:1-19. doi:10.1080/1023666x.2022.2110133
apa: Herberg, A., & Kuckling, D. (2022). Branching analysis of β-cyclodextrin-based
poly(N-isopropylacrylamide) star polymers using triple detection SEC. International
Journal of Polymer Analysis and Characterization, 1–19. https://doi.org/10.1080/1023666x.2022.2110133
bibtex: '@article{Herberg_Kuckling_2022, title={Branching analysis of β-cyclodextrin-based
poly(N-isopropylacrylamide) star polymers using triple detection SEC},
DOI={10.1080/1023666x.2022.2110133},
journal={International Journal of Polymer Analysis and Characterization}, publisher={Informa
UK Limited}, author={Herberg, Artjom and Kuckling, Dirk}, year={2022}, pages={1–19}
}'
chicago: Herberg, Artjom, and Dirk Kuckling. “Branching Analysis of β-Cyclodextrin-Based
Poly(N-Isopropylacrylamide) Star Polymers Using Triple Detection SEC.”
International Journal of Polymer Analysis and Characterization, 2022, 1–19.
https://doi.org/10.1080/1023666x.2022.2110133.
ieee: 'A. Herberg and D. Kuckling, “Branching analysis of β-cyclodextrin-based poly(N-isopropylacrylamide)
star polymers using triple detection SEC,” International Journal of Polymer
Analysis and Characterization, pp. 1–19, 2022, doi: 10.1080/1023666x.2022.2110133.'
mla: Herberg, Artjom, and Dirk Kuckling. “Branching Analysis of β-Cyclodextrin-Based
Poly(N-Isopropylacrylamide) Star Polymers Using Triple Detection SEC.”
International Journal of Polymer Analysis and Characterization, Informa
UK Limited, 2022, pp. 1–19, doi:10.1080/1023666x.2022.2110133.
short: A. Herberg, D. Kuckling, International Journal of Polymer Analysis and Characterization
(2022) 1–19.
date_created: 2022-08-17T06:28:55Z
date_updated: 2023-01-10T08:13:52Z
department:
- _id: '163'
doi: 10.1080/1023666x.2022.2110133
keyword:
- Size-exclusion chromatography
- triple detection
- branching analysis
- star polymers
- poly(N-isopropylacrylamide)
- β-cyclodextrin
language:
- iso: eng
page: 1-19
publication: International Journal of Polymer Analysis and Characterization
publication_identifier:
issn:
- 1023-666X
- 1563-5341
publication_status: published
publisher: Informa UK Limited
status: public
title: Branching analysis of β-cyclodextrin-based poly(N-isopropylacrylamide)
star polymers using triple detection SEC
type: journal_article
user_id: '94'
year: '2022'
...
---
_id: '59617'
abstract:
- lang: eng
text: 'There is an increasing interest in sensing applications for a variety
of analytes in aqueous environments, as conventional methods do not work reliably
under humid conditions or they require complex equipment with experienced operators.
Hydrogel sensors are easy to fabricate, are incredibly sensitive, and have broad
dynamic ranges. Experiments on their robustness, reliability, and reusability
have indicated the possible long-term applications of these systems in a variety
of fields, including disease diagnosis, detection of pharmaceuticals, and in environmental
testing. It is possible to produce hydrogels, which, upon sensing a specific analyte,
can adsorb it onto their 3D-structure and can therefore be used to remove them
from a given environment. High specificity can be obtained by using molecularly
imprinted polymers. Typical detection principles involve optical methods including
fluorescence and chemiluminescence, and volume changes in colloidal photonic crystals,
as well as electrochemical methods. Here, we explore the current research utilizing
hydrogel-based sensors in three main areas: (1) biomedical applications, (2) for
detecting and quantifying pharmaceuticals of interest, and (3) detecting and quantifying
environmental contaminants in aqueous environments.'
article_number: '768'
author:
- first_name: Katharina
full_name: Völlmecke, Katharina
last_name: Völlmecke
- first_name: Rowshon
full_name: Afroz, Rowshon
last_name: Afroz
- first_name: Sascha
full_name: Bierbach, Sascha
last_name: Bierbach
- first_name: Lee Josephine
full_name: Brenker, Lee Josephine
last_name: Brenker
- first_name: Sebastian
full_name: Frücht, Sebastian
last_name: Frücht
- first_name: Alexandra
full_name: Glass, Alexandra
last_name: Glass
- first_name: Ryland
full_name: Giebelhaus, Ryland
last_name: Giebelhaus
- first_name: Axel
full_name: Hoppe, Axel
id: '62844'
last_name: Hoppe
- first_name: Karen
full_name: Kanemaru, Karen
last_name: Kanemaru
- first_name: Michal
full_name: Lazarek, Michal
last_name: Lazarek
- first_name: Lukas
full_name: Rabbe, Lukas
last_name: Rabbe
- first_name: Longfei
full_name: Song, Longfei
last_name: Song
- first_name: Andrea
full_name: Velasco Suarez, Andrea
last_name: Velasco Suarez
- first_name: Shuang
full_name: Wu, Shuang
last_name: Wu
- first_name: Michael
full_name: Serpe, Michael
last_name: Serpe
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Völlmecke K, Afroz R, Bierbach S, et al. Hydrogel-Based Biosensors. Gels.
2022;8(12). doi:10.3390/gels8120768
apa: Völlmecke, K., Afroz, R., Bierbach, S., Brenker, L. J., Frücht, S., Glass,
A., Giebelhaus, R., Hoppe, A., Kanemaru, K., Lazarek, M., Rabbe, L., Song, L.,
Velasco Suarez, A., Wu, S., Serpe, M., & Kuckling, D. (2022). Hydrogel-Based
Biosensors. Gels, 8(12), Article 768. https://doi.org/10.3390/gels8120768
bibtex: '@article{Völlmecke_Afroz_Bierbach_Brenker_Frücht_Glass_Giebelhaus_Hoppe_Kanemaru_Lazarek_et
al._2022, title={Hydrogel-Based Biosensors}, volume={8}, DOI={10.3390/gels8120768},
number={12768}, journal={Gels}, publisher={MDPI AG}, author={Völlmecke, Katharina
and Afroz, Rowshon and Bierbach, Sascha and Brenker, Lee Josephine and Frücht,
Sebastian and Glass, Alexandra and Giebelhaus, Ryland and Hoppe, Axel and Kanemaru,
Karen and Lazarek, Michal and et al.}, year={2022} }'
chicago: Völlmecke, Katharina, Rowshon Afroz, Sascha Bierbach, Lee Josephine Brenker,
Sebastian Frücht, Alexandra Glass, Ryland Giebelhaus, et al. “Hydrogel-Based Biosensors.”
Gels 8, no. 12 (2022). https://doi.org/10.3390/gels8120768.
ieee: 'K. Völlmecke et al., “Hydrogel-Based Biosensors,” Gels, vol.
8, no. 12, Art. no. 768, 2022, doi: 10.3390/gels8120768.'
mla: Völlmecke, Katharina, et al. “Hydrogel-Based Biosensors.” Gels, vol.
8, no. 12, 768, MDPI AG, 2022, doi:10.3390/gels8120768.
short: K. Völlmecke, R. Afroz, S. Bierbach, L.J. Brenker, S. Frücht, A. Glass, R.
Giebelhaus, A. Hoppe, K. Kanemaru, M. Lazarek, L. Rabbe, L. Song, A. Velasco Suarez,
S. Wu, M. Serpe, D. Kuckling, Gels 8 (2022).
date_created: 2025-04-22T05:59:29Z
date_updated: 2025-04-22T06:12:07Z
department:
- _id: '311'
doi: 10.3390/gels8120768
intvolume: ' 8'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.mdpi.com/2310-2861/8/12/768
oa: '1'
publication: Gels
publication_identifier:
issn:
- 2310-2861
publication_status: published
publisher: MDPI AG
quality_controlled: '1'
status: public
title: Hydrogel-Based Biosensors
type: journal_article
user_id: '62844'
volume: 8
year: '2022'
...
---
_id: '23701'
article_number: '120326'
author:
- first_name: Timo
full_name: Schoppa, Timo
last_name: Schoppa
- first_name: Dimitri
full_name: Jung, Dimitri
last_name: Jung
- first_name: Tarik
full_name: Rust, Tarik
last_name: Rust
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
citation:
ama: Schoppa T, Jung D, Rust T, Mulac D, Kuckling D, Langer K. Light-responsive
polymeric nanoparticles based on a novel nitropiperonal based polyester as drug
delivery systems for photosensitizers in PDT. International Journal of Pharmaceutics.
2021;597. doi:10.1016/j.ijpharm.2021.120326
apa: Schoppa, T., Jung, D., Rust, T., Mulac, D., Kuckling, D., & Langer, K.
(2021). Light-responsive polymeric nanoparticles based on a novel nitropiperonal
based polyester as drug delivery systems for photosensitizers in PDT. International
Journal of Pharmaceutics, 597, Article 120326. https://doi.org/10.1016/j.ijpharm.2021.120326
bibtex: '@article{Schoppa_Jung_Rust_Mulac_Kuckling_Langer_2021, title={Light-responsive
polymeric nanoparticles based on a novel nitropiperonal based polyester as drug
delivery systems for photosensitizers in PDT}, volume={597}, DOI={10.1016/j.ijpharm.2021.120326},
number={120326}, journal={International Journal of Pharmaceutics}, publisher={Elsevier},
author={Schoppa, Timo and Jung, Dimitri and Rust, Tarik and Mulac, Dennis and
Kuckling, Dirk and Langer, Klaus}, year={2021} }'
chicago: Schoppa, Timo, Dimitri Jung, Tarik Rust, Dennis Mulac, Dirk Kuckling, and
Klaus Langer. “Light-Responsive Polymeric Nanoparticles Based on a Novel Nitropiperonal
Based Polyester as Drug Delivery Systems for Photosensitizers in PDT.” International
Journal of Pharmaceutics 597 (2021). https://doi.org/10.1016/j.ijpharm.2021.120326.
ieee: 'T. Schoppa, D. Jung, T. Rust, D. Mulac, D. Kuckling, and K. Langer, “Light-responsive
polymeric nanoparticles based on a novel nitropiperonal based polyester as drug
delivery systems for photosensitizers in PDT,” International Journal of Pharmaceutics,
vol. 597, Art. no. 120326, 2021, doi: 10.1016/j.ijpharm.2021.120326.'
mla: Schoppa, Timo, et al. “Light-Responsive Polymeric Nanoparticles Based on a
Novel Nitropiperonal Based Polyester as Drug Delivery Systems for Photosensitizers
in PDT.” International Journal of Pharmaceutics, vol. 597, 120326, Elsevier,
2021, doi:10.1016/j.ijpharm.2021.120326.
short: T. Schoppa, D. Jung, T. Rust, D. Mulac, D. Kuckling, K. Langer, International
Journal of Pharmaceutics 597 (2021).
date_created: 2021-09-02T12:48:00Z
date_updated: 2022-07-28T09:57:44Z
department:
- _id: '311'
doi: 10.1016/j.ijpharm.2021.120326
intvolume: ' 597'
language:
- iso: eng
publication: International Journal of Pharmaceutics
publication_identifier:
issn:
- 0378-5173
publication_status: published
publisher: Elsevier
status: public
title: Light-responsive polymeric nanoparticles based on a novel nitropiperonal based
polyester as drug delivery systems for photosensitizers in PDT
type: journal_article
user_id: '94'
volume: 597
year: '2021'
...
---
_id: '23662'
author:
- first_name: Tarik
full_name: Rust, Tarik
last_name: Rust
- first_name: Dimitri
full_name: Jung, Dimitri
last_name: Jung
- first_name: Axel
full_name: Hoppe, Axel
last_name: Hoppe
- first_name: Timo
full_name: Schoppa, Timo
last_name: Schoppa
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Rust T, Jung D, Hoppe A, Schoppa T, Langer K, Kuckling D. Backbone-Degradable
(Co-)Polymers for Light-Triggered Drug Delivery. ACS Applied Polymer Materials.
2021;3(8):3831-3842. doi:10.1021/acsapm.1c00411
apa: Rust, T., Jung, D., Hoppe, A., Schoppa, T., Langer, K., & Kuckling, D.
(2021). Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery. ACS
Applied Polymer Materials, 3(8), 3831–3842. https://doi.org/10.1021/acsapm.1c00411
bibtex: '@article{Rust_Jung_Hoppe_Schoppa_Langer_Kuckling_2021, title={Backbone-Degradable
(Co-)Polymers for Light-Triggered Drug Delivery}, volume={3}, DOI={10.1021/acsapm.1c00411},
number={8}, journal={ACS Applied Polymer Materials}, publisher={ACS}, author={Rust,
Tarik and Jung, Dimitri and Hoppe, Axel and Schoppa, Timo and Langer, Klaus and
Kuckling, Dirk}, year={2021}, pages={3831–3842} }'
chicago: 'Rust, Tarik, Dimitri Jung, Axel Hoppe, Timo Schoppa, Klaus Langer, and
Dirk Kuckling. “Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery.”
ACS Applied Polymer Materials 3, no. 8 (2021): 3831–42. https://doi.org/10.1021/acsapm.1c00411.'
ieee: 'T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, and D. Kuckling, “Backbone-Degradable
(Co-)Polymers for Light-Triggered Drug Delivery,” ACS Applied Polymer Materials,
vol. 3, no. 8, pp. 3831–3842, 2021, doi: 10.1021/acsapm.1c00411.'
mla: Rust, Tarik, et al. “Backbone-Degradable (Co-)Polymers for Light-Triggered
Drug Delivery.” ACS Applied Polymer Materials, vol. 3, no. 8, ACS, 2021,
pp. 3831–42, doi:10.1021/acsapm.1c00411.
short: T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, D. Kuckling, ACS Applied
Polymer Materials 3 (2021) 3831–3842.
date_created: 2021-09-02T06:41:16Z
date_updated: 2022-07-28T10:00:40Z
department:
- _id: '311'
doi: 10.1021/acsapm.1c00411
intvolume: ' 3'
issue: '8'
language:
- iso: eng
page: 3831-3842
publication: ACS Applied Polymer Materials
publication_identifier:
issn:
- 2637-6105
- 2637-6105
publication_status: published
publisher: ACS
status: public
title: Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery
type: journal_article
user_id: '94'
volume: 3
year: '2021'
...
---
_id: '23699'
author:
- first_name: Carsten J.
full_name: Schmiegel, Carsten J.
last_name: Schmiegel
- first_name: Rene
full_name: Baier, Rene
last_name: Baier
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Schmiegel CJ, Baier R, Kuckling D. Direct Asymmetric Aldol Reaction in Continuous
Flow Using Gel‐Bound Organocatalysts. European Journal of Organic Chemistry.
Published online 2021:2578-2586. doi:10.1002/ejoc.202100268
apa: Schmiegel, C. J., Baier, R., & Kuckling, D. (2021). Direct Asymmetric Aldol
Reaction in Continuous Flow Using Gel‐Bound Organocatalysts. European Journal
of Organic Chemistry, 2578–2586. https://doi.org/10.1002/ejoc.202100268
bibtex: '@article{Schmiegel_Baier_Kuckling_2021, title={Direct Asymmetric Aldol
Reaction in Continuous Flow Using Gel‐Bound Organocatalysts}, DOI={10.1002/ejoc.202100268},
journal={European Journal of Organic Chemistry}, publisher={Wiley-VCH}, author={Schmiegel,
Carsten J. and Baier, Rene and Kuckling, Dirk}, year={2021}, pages={2578–2586}
}'
chicago: Schmiegel, Carsten J., Rene Baier, and Dirk Kuckling. “Direct Asymmetric
Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts.” European
Journal of Organic Chemistry, 2021, 2578–86. https://doi.org/10.1002/ejoc.202100268.
ieee: 'C. J. Schmiegel, R. Baier, and D. Kuckling, “Direct Asymmetric Aldol Reaction
in Continuous Flow Using Gel‐Bound Organocatalysts,” European Journal of Organic
Chemistry, pp. 2578–2586, 2021, doi: 10.1002/ejoc.202100268.'
mla: Schmiegel, Carsten J., et al. “Direct Asymmetric Aldol Reaction in Continuous
Flow Using Gel‐Bound Organocatalysts.” European Journal of Organic Chemistry,
Wiley-VCH, 2021, pp. 2578–86, doi:10.1002/ejoc.202100268.
short: C.J. Schmiegel, R. Baier, D. Kuckling, European Journal of Organic Chemistry
(2021) 2578–2586.
date_created: 2021-09-02T12:44:25Z
date_updated: 2022-07-28T09:57:57Z
department:
- _id: '311'
doi: 10.1002/ejoc.202100268
language:
- iso: eng
page: 2578-2586
publication: European Journal of Organic Chemistry
publication_identifier:
issn:
- 1434-193X
- 1099-0690
publication_status: published
publisher: Wiley-VCH
status: public
title: Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts
type: journal_article
user_id: '94'
year: '2021'
...