---
_id: '32406'
abstract:
- lang: eng
text: The efficient loading of DNA nanostructures with intercalating or
groove-binding drugs is an important prerequisite for various applications in
drug delivery. However, unambiguous verification and quantification of successful
drug loading...
author:
- first_name: Marcel
full_name: Hanke, Marcel
last_name: Hanke
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Hanke M, Grundmeier G, Keller A. Direct visualization of the drug loading of
single DNA origami nanostructures by AFM-IR nanospectroscopy. Nanoscale.
2022;14:11552-11560. doi:10.1039/d2nr02701a
apa: Hanke, M., Grundmeier, G., & Keller, A. (2022). Direct visualization of
the drug loading of single DNA origami nanostructures by AFM-IR nanospectroscopy.
Nanoscale, 14, 11552–11560. https://doi.org/10.1039/d2nr02701a
bibtex: '@article{Hanke_Grundmeier_Keller_2022, title={Direct visualization of the
drug loading of single DNA origami nanostructures by AFM-IR nanospectroscopy},
volume={14}, DOI={10.1039/d2nr02701a},
journal={Nanoscale}, publisher={Royal Society of Chemistry (RSC)}, author={Hanke,
Marcel and Grundmeier, Guido and Keller, Adrian}, year={2022}, pages={11552–11560}
}'
chicago: 'Hanke, Marcel, Guido Grundmeier, and Adrian Keller. “Direct Visualization
of the Drug Loading of Single DNA Origami Nanostructures by AFM-IR Nanospectroscopy.”
Nanoscale 14 (2022): 11552–60. https://doi.org/10.1039/d2nr02701a.'
ieee: 'M. Hanke, G. Grundmeier, and A. Keller, “Direct visualization of the drug
loading of single DNA origami nanostructures by AFM-IR nanospectroscopy,” Nanoscale,
vol. 14, pp. 11552–11560, 2022, doi: 10.1039/d2nr02701a.'
mla: Hanke, Marcel, et al. “Direct Visualization of the Drug Loading of Single DNA
Origami Nanostructures by AFM-IR Nanospectroscopy.” Nanoscale, vol. 14,
Royal Society of Chemistry (RSC), 2022, pp. 11552–60, doi:10.1039/d2nr02701a.
short: M. Hanke, G. Grundmeier, A. Keller, Nanoscale 14 (2022) 11552–11560.
date_created: 2022-07-22T10:06:08Z
date_updated: 2022-08-18T08:41:59Z
department:
- _id: '302'
doi: 10.1039/d2nr02701a
intvolume: ' 14'
keyword:
- General Materials Science
language:
- iso: eng
page: 11552-11560
publication: Nanoscale
publication_identifier:
issn:
- 2040-3364
- 2040-3372
publication_status: published
publisher: Royal Society of Chemistry (RSC)
status: public
title: Direct visualization of the drug loading of single DNA origami nanostructures
by AFM-IR nanospectroscopy
type: journal_article
user_id: '48864'
volume: 14
year: '2022'
...
---
_id: '30103'
author:
- first_name: Jingyuan
full_name: Huang, Jingyuan
last_name: Huang
- first_name: Alejandro Gonzalez
full_name: Orive, Alejandro Gonzalez
last_name: Orive
- first_name: Jan Tobias
full_name: Krüger, Jan Tobias
id: '44307'
last_name: Krüger
orcid: 0000-0002-0827-9654
- first_name: Kay-Peter
full_name: Hoyer, Kay-Peter
id: '48411'
last_name: Hoyer
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
citation:
ama: Huang J, Orive AG, Krüger JT, Hoyer K-P, Keller A, Grundmeier G. Influence
of proteins on the corrosion of a conventional and selective laser beam melted
FeMn alloy in physiological electrolytes. Corrosion Science. 2022;200:110186.
doi:10.1016/j.corsci.2022.110186
apa: Huang, J., Orive, A. G., Krüger, J. T., Hoyer, K.-P., Keller, A., & Grundmeier,
G. (2022). Influence of proteins on the corrosion of a conventional and selective
laser beam melted FeMn alloy in physiological electrolytes. Corrosion Science,
200, 110186. https://doi.org/10.1016/j.corsci.2022.110186
bibtex: '@article{Huang_Orive_Krüger_Hoyer_Keller_Grundmeier_2022, title={Influence
of proteins on the corrosion of a conventional and selective laser beam melted
FeMn alloy in physiological electrolytes}, volume={200}, DOI={10.1016/j.corsci.2022.110186},
journal={Corrosion Science}, publisher={Elsevier BV}, author={Huang, Jingyuan
and Orive, Alejandro Gonzalez and Krüger, Jan Tobias and Hoyer, Kay-Peter and
Keller, Adrian and Grundmeier, Guido}, year={2022}, pages={110186} }'
chicago: 'Huang, Jingyuan, Alejandro Gonzalez Orive, Jan Tobias Krüger, Kay-Peter
Hoyer, Adrian Keller, and Guido Grundmeier. “Influence of Proteins on the Corrosion
of a Conventional and Selective Laser Beam Melted FeMn Alloy in Physiological
Electrolytes.” Corrosion Science 200 (2022): 110186. https://doi.org/10.1016/j.corsci.2022.110186.'
ieee: 'J. Huang, A. G. Orive, J. T. Krüger, K.-P. Hoyer, A. Keller, and G. Grundmeier,
“Influence of proteins on the corrosion of a conventional and selective laser
beam melted FeMn alloy in physiological electrolytes,” Corrosion Science,
vol. 200, p. 110186, 2022, doi: 10.1016/j.corsci.2022.110186.'
mla: Huang, Jingyuan, et al. “Influence of Proteins on the Corrosion of a Conventional
and Selective Laser Beam Melted FeMn Alloy in Physiological Electrolytes.” Corrosion
Science, vol. 200, Elsevier BV, 2022, p. 110186, doi:10.1016/j.corsci.2022.110186.
short: J. Huang, A.G. Orive, J.T. Krüger, K.-P. Hoyer, A. Keller, G. Grundmeier,
Corrosion Science 200 (2022) 110186.
date_created: 2022-02-25T09:32:43Z
date_updated: 2023-04-27T16:47:42Z
department:
- _id: '302'
- _id: '158'
doi: 10.1016/j.corsci.2022.110186
intvolume: ' 200'
keyword:
- General Materials Science
- General Chemical Engineering
- General Chemistry
language:
- iso: eng
page: '110186'
publication: Corrosion Science
publication_identifier:
issn:
- 0010-938X
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
status: public
title: Influence of proteins on the corrosion of a conventional and selective laser
beam melted FeMn alloy in physiological electrolytes
type: journal_article
user_id: '48411'
volume: 200
year: '2022'
...
---
_id: '41504'
article_number: '110186'
author:
- first_name: Jingyuan
full_name: Huang, Jingyuan
last_name: Huang
- first_name: Alejandro
full_name: Gonzalez Orive, Alejandro
last_name: Gonzalez Orive
- first_name: Jan Tobias
full_name: Krüger, Jan Tobias
id: '44307'
last_name: Krüger
orcid: 0000-0002-0827-9654
- first_name: Kay-Peter
full_name: Hoyer, Kay-Peter
id: '48411'
last_name: Hoyer
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
citation:
ama: Huang J, Gonzalez Orive A, Krüger JT, Hoyer K-P, Keller A, Grundmeier G. Influence
of proteins on the corrosion of a conventional and selective laser beam melted
FeMn alloy in physiological electrolytes. Corrosion Science. 2022;200.
doi:10.1016/j.corsci.2022.110186
apa: Huang, J., Gonzalez Orive, A., Krüger, J. T., Hoyer, K.-P., Keller, A., &
Grundmeier, G. (2022). Influence of proteins on the corrosion of a conventional
and selective laser beam melted FeMn alloy in physiological electrolytes. Corrosion
Science, 200, Article 110186. https://doi.org/10.1016/j.corsci.2022.110186
bibtex: '@article{Huang_Gonzalez Orive_Krüger_Hoyer_Keller_Grundmeier_2022, title={Influence
of proteins on the corrosion of a conventional and selective laser beam melted
FeMn alloy in physiological electrolytes}, volume={200}, DOI={10.1016/j.corsci.2022.110186},
number={110186}, journal={Corrosion Science}, publisher={Elsevier BV}, author={Huang,
Jingyuan and Gonzalez Orive, Alejandro and Krüger, Jan Tobias and Hoyer, Kay-Peter
and Keller, Adrian and Grundmeier, Guido}, year={2022} }'
chicago: Huang, Jingyuan, Alejandro Gonzalez Orive, Jan Tobias Krüger, Kay-Peter
Hoyer, Adrian Keller, and Guido Grundmeier. “Influence of Proteins on the Corrosion
of a Conventional and Selective Laser Beam Melted FeMn Alloy in Physiological
Electrolytes.” Corrosion Science 200 (2022). https://doi.org/10.1016/j.corsci.2022.110186.
ieee: 'J. Huang, A. Gonzalez Orive, J. T. Krüger, K.-P. Hoyer, A. Keller, and G.
Grundmeier, “Influence of proteins on the corrosion of a conventional and selective
laser beam melted FeMn alloy in physiological electrolytes,” Corrosion Science,
vol. 200, Art. no. 110186, 2022, doi: 10.1016/j.corsci.2022.110186.'
mla: Huang, Jingyuan, et al. “Influence of Proteins on the Corrosion of a Conventional
and Selective Laser Beam Melted FeMn Alloy in Physiological Electrolytes.” Corrosion
Science, vol. 200, 110186, Elsevier BV, 2022, doi:10.1016/j.corsci.2022.110186.
short: J. Huang, A. Gonzalez Orive, J.T. Krüger, K.-P. Hoyer, A. Keller, G. Grundmeier,
Corrosion Science 200 (2022).
date_created: 2023-02-02T14:30:17Z
date_updated: 2023-04-27T16:47:31Z
department:
- _id: '9'
- _id: '158'
doi: 10.1016/j.corsci.2022.110186
intvolume: ' 200'
keyword:
- General Materials Science
- General Chemical Engineering
- General Chemistry
language:
- iso: eng
publication: Corrosion Science
publication_identifier:
issn:
- 0010-938X
publication_status: published
publisher: Elsevier BV
status: public
title: Influence of proteins on the corrosion of a conventional and selective laser
beam melted FeMn alloy in physiological electrolytes
type: journal_article
user_id: '48411'
volume: 200
year: '2022'
...
---
_id: '26011'
author:
- first_name: Dominik
full_name: Hense, Dominik
last_name: Hense
- first_name: Anne
full_name: Büngeler, Anne
last_name: Büngeler
- first_name: Fabian
full_name: Kollmann, Fabian
last_name: Kollmann
- first_name: Marcel
full_name: Hanke, Marcel
last_name: Hanke
- first_name: Alejandro
full_name: Orive, Alejandro
last_name: Orive
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Klaus
full_name: Huber, Klaus
last_name: Huber
- first_name: Oliver I.
full_name: Strube, Oliver I.
last_name: Strube
citation:
ama: Hense D, Büngeler A, Kollmann F, et al. Self-Assembled Fibrinogen Hydro- and
Aerogels with Fibrin-like 3D Structures. Biomacromolecules. 2021;22:4084–4094.
doi:10.1021/acs.biomac.1c00489
apa: Hense, D., Büngeler, A., Kollmann, F., Hanke, M., Orive, A., Keller, A., Grundmeier,
G., Huber, K., & Strube, O. I. (2021). Self-Assembled Fibrinogen Hydro- and
Aerogels with Fibrin-like 3D Structures. Biomacromolecules, 22,
4084–4094. https://doi.org/10.1021/acs.biomac.1c00489
bibtex: '@article{Hense_Büngeler_Kollmann_Hanke_Orive_Keller_Grundmeier_Huber_Strube_2021,
title={Self-Assembled Fibrinogen Hydro- and Aerogels with Fibrin-like 3D Structures},
volume={22}, DOI={10.1021/acs.biomac.1c00489},
journal={Biomacromolecules}, author={Hense, Dominik and Büngeler, Anne and Kollmann,
Fabian and Hanke, Marcel and Orive, Alejandro and Keller, Adrian and Grundmeier,
Guido and Huber, Klaus and Strube, Oliver I.}, year={2021}, pages={4084–4094}
}'
chicago: 'Hense, Dominik, Anne Büngeler, Fabian Kollmann, Marcel Hanke, Alejandro
Orive, Adrian Keller, Guido Grundmeier, Klaus Huber, and Oliver I. Strube. “Self-Assembled
Fibrinogen Hydro- and Aerogels with Fibrin-like 3D Structures.” Biomacromolecules
22 (2021): 4084–4094. https://doi.org/10.1021/acs.biomac.1c00489.'
ieee: 'D. Hense et al., “Self-Assembled Fibrinogen Hydro- and Aerogels with
Fibrin-like 3D Structures,” Biomacromolecules, vol. 22, pp. 4084–4094,
2021, doi: 10.1021/acs.biomac.1c00489.'
mla: Hense, Dominik, et al. “Self-Assembled Fibrinogen Hydro- and Aerogels with
Fibrin-like 3D Structures.” Biomacromolecules, vol. 22, 2021, pp. 4084–4094,
doi:10.1021/acs.biomac.1c00489.
short: D. Hense, A. Büngeler, F. Kollmann, M. Hanke, A. Orive, A. Keller, G. Grundmeier,
K. Huber, O.I. Strube, Biomacromolecules 22 (2021) 4084–4094.
date_created: 2021-10-11T07:31:04Z
date_updated: 2022-01-06T06:57:15Z
department:
- _id: '302'
- _id: '314'
- _id: '387'
doi: 10.1021/acs.biomac.1c00489
intvolume: ' 22'
language:
- iso: eng
page: 4084–4094
publication: Biomacromolecules
publication_identifier:
issn:
- 1525-7797
- 1526-4602
publication_status: published
status: public
title: Self-Assembled Fibrinogen Hydro- and Aerogels with Fibrin-like 3D Structures
type: journal_article
user_id: '48864'
volume: 22
year: '2021'
...
---
_id: '26759'
abstract:
- lang: eng
text: Coatings of modified TiO2 nanoparticles (TiO2-m) have been shown to
effectively and selectively trap non-adherent cancer cells, with an enormous potential
for applications in photodynamic therapy (PDT). Leukemia cells have a remarkable
affinity for TiO2-m coatings, adhering to the surface by membrane structures and
exhibiting morphologic characteristics of amoeboid locomotion. However, the details
of the cell–substrate interaction induced by the TiO2-m coating remain elusive.
With the aim to obtain a better understanding of this phenomenon, leukemia cell
adhesion to such coatings was characterized by atomic force microscopy (AFM) for
short contact times up to 60 min. The cell and membrane morphological parameters
mean cell height, contact area, cell volume, and membrane roughness were determined
at different contact times. These results reveal cell expansion and contraction
phases occurring during the initial stage of adhesion. Subsequently, the leukemic
cells reach what appears to be a new resting state, characterized by pinning of
the cell membrane by TiO2-m nanoparticle aggregates protruding from the coating
surface.
author:
- first_name: Jaime Andres
full_name: Garcia Diosa, Jaime Andres
last_name: Garcia Diosa
- first_name: Alejandro
full_name: Gonzalez Orive, Alejandro
last_name: Gonzalez Orive
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Ruben Jesus
full_name: Camargo Amado, Ruben Jesus
last_name: Camargo Amado
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Garcia Diosa JA, Gonzalez Orive A, Grundmeier G, Camargo Amado RJ, Keller A.
Morphological Dynamics of Leukemia Cells on TiO2 Nanoparticle Coatings Studied
by AFM. Applied Sciences. 2021;11:9898. doi:10.3390/app11219898
apa: Garcia Diosa, J. A., Gonzalez Orive, A., Grundmeier, G., Camargo Amado, R.
J., & Keller, A. (2021). Morphological Dynamics of Leukemia Cells on TiO2
Nanoparticle Coatings Studied by AFM. Applied Sciences, 11, 9898.
https://doi.org/10.3390/app11219898
bibtex: '@article{Garcia Diosa_Gonzalez Orive_Grundmeier_Camargo Amado_Keller_2021,
title={Morphological Dynamics of Leukemia Cells on TiO2 Nanoparticle Coatings
Studied by AFM}, volume={11}, DOI={10.3390/app11219898},
journal={Applied Sciences}, author={Garcia Diosa, Jaime Andres and Gonzalez Orive,
Alejandro and Grundmeier, Guido and Camargo Amado, Ruben Jesus and Keller, Adrian},
year={2021}, pages={9898} }'
chicago: 'Garcia Diosa, Jaime Andres, Alejandro Gonzalez Orive, Guido Grundmeier,
Ruben Jesus Camargo Amado, and Adrian Keller. “Morphological Dynamics of Leukemia
Cells on TiO2 Nanoparticle Coatings Studied by AFM.” Applied Sciences 11
(2021): 9898. https://doi.org/10.3390/app11219898.'
ieee: 'J. A. Garcia Diosa, A. Gonzalez Orive, G. Grundmeier, R. J. Camargo Amado,
and A. Keller, “Morphological Dynamics of Leukemia Cells on TiO2 Nanoparticle
Coatings Studied by AFM,” Applied Sciences, vol. 11, p. 9898, 2021, doi:
10.3390/app11219898.'
mla: Garcia Diosa, Jaime Andres, et al. “Morphological Dynamics of Leukemia Cells
on TiO2 Nanoparticle Coatings Studied by AFM.” Applied Sciences, vol. 11,
2021, p. 9898, doi:10.3390/app11219898.
short: J.A. Garcia Diosa, A. Gonzalez Orive, G. Grundmeier, R.J. Camargo Amado,
A. Keller, Applied Sciences 11 (2021) 9898.
date_created: 2021-10-25T07:48:17Z
date_updated: 2022-01-06T06:57:27Z
department:
- _id: '302'
doi: 10.3390/app11219898
intvolume: ' 11'
language:
- iso: eng
page: '9898'
publication: Applied Sciences
publication_identifier:
issn:
- 2076-3417
publication_status: published
status: public
title: Morphological Dynamics of Leukemia Cells on TiO2 Nanoparticle Coatings Studied
by AFM
type: journal_article
user_id: '48864'
volume: 11
year: '2021'
...
---
_id: '26985'
author:
- first_name: Jaime Andrés
full_name: Garcia-Diosa, Jaime Andrés
last_name: Garcia-Diosa
- first_name: Alejandro Gonzalez
full_name: Orive, Alejandro Gonzalez
last_name: Orive
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: Rubén Jesús
full_name: Camargo-Amado, Rubén Jesús
last_name: Camargo-Amado
citation:
ama: Garcia-Diosa JA, Orive AG, Grundmeier G, Keller A, Camargo-Amado RJ. Influence
of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings on cancer
cell adhesion. Surface and Coatings Technology. Published online 2021:127823.
doi:10.1016/j.surfcoat.2021.127823
apa: Garcia-Diosa, J. A., Orive, A. G., Grundmeier, G., Keller, A., & Camargo-Amado,
R. J. (2021). Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle
coatings on cancer cell adhesion. Surface and Coatings Technology, 127823.
https://doi.org/10.1016/j.surfcoat.2021.127823
bibtex: '@article{Garcia-Diosa_Orive_Grundmeier_Keller_Camargo-Amado_2021, title={Influence
of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings on cancer
cell adhesion}, DOI={10.1016/j.surfcoat.2021.127823},
journal={Surface and Coatings Technology}, author={Garcia-Diosa, Jaime Andrés
and Orive, Alejandro Gonzalez and Grundmeier, Guido and Keller, Adrian and Camargo-Amado,
Rubén Jesús}, year={2021}, pages={127823} }'
chicago: Garcia-Diosa, Jaime Andrés, Alejandro Gonzalez Orive, Guido Grundmeier,
Adrian Keller, and Rubén Jesús Camargo-Amado. “Influence of Thickness, Homogeneity,
and Morphology of TiO2-m Nanoparticle Coatings on Cancer Cell Adhesion.” Surface
and Coatings Technology, 2021, 127823. https://doi.org/10.1016/j.surfcoat.2021.127823.
ieee: 'J. A. Garcia-Diosa, A. G. Orive, G. Grundmeier, A. Keller, and R. J. Camargo-Amado,
“Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings
on cancer cell adhesion,” Surface and Coatings Technology, p. 127823, 2021,
doi: 10.1016/j.surfcoat.2021.127823.'
mla: Garcia-Diosa, Jaime Andrés, et al. “Influence of Thickness, Homogeneity, and
Morphology of TiO2-m Nanoparticle Coatings on Cancer Cell Adhesion.” Surface
and Coatings Technology, 2021, p. 127823, doi:10.1016/j.surfcoat.2021.127823.
short: J.A. Garcia-Diosa, A.G. Orive, G. Grundmeier, A. Keller, R.J. Camargo-Amado,
Surface and Coatings Technology (2021) 127823.
date_created: 2021-10-27T13:00:23Z
date_updated: 2022-01-06T06:57:31Z
department:
- _id: '302'
doi: 10.1016/j.surfcoat.2021.127823
language:
- iso: eng
page: '127823'
publication: Surface and Coatings Technology
publication_identifier:
issn:
- 0257-8972
publication_status: published
status: public
title: Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle
coatings on cancer cell adhesion
type: journal_article
user_id: '48864'
year: '2021'
...
---
_id: '22636'
abstract:
- lang: eng
text: The effects that solid–liquid interfaces exert on the aggregation
of proteins and peptides are of high relevance for various fields of basic and
applied research, ranging from molecular biology and biomedicine to nanotechnology.
While the influence of surface chemistry has received a lot of attention in this
context, the role of surface topography has mostly been neglected so far. In this
work, therefore, we investigate the aggregation of the type 2 diabetes-associated
peptide hormone hIAPP in contact with flat and nanopatterned silicon oxide surfaces.
The nanopatterned surfaces are produced by ion beam irradiation, resulting in
well-defined anisotropic ripple patterns with heights and periodicities of about
1.5 and 30 nm, respectively. Using time-lapse atomic force microscopy, the morphology
of the hIAPP aggregates is characterized quantitatively. Aggregation results in
both amorphous aggregates and amyloid fibrils, with the presence of the nanopatterns
leading to retarded fibrillization and stronger amorphous aggregation. This is
attributed to structural differences in the amorphous aggregates formed at the
nanopatterned surface, which result in a lower propensity for nucleating amyloid
fibrillization. Our results demonstrate that nanoscale surface topography may
modulate peptide and protein aggregation pathways in complex and intricate ways.
author:
- first_name: Marcel
full_name: Hanke, Marcel
last_name: Hanke
- first_name: Yu
full_name: Yang, Yu
last_name: Yang
- first_name: Yuxin
full_name: Ji, Yuxin
last_name: Ji
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Hanke M, Yang Y, Ji Y, Grundmeier G, Keller A. Nanoscale Surface Topography
Modulates hIAPP Aggregation Pathways at Solid–Liquid Interfaces. International
Journal of Molecular Sciences. 2021;22:5142. doi:10.3390/ijms22105142
apa: Hanke, M., Yang, Y., Ji, Y., Grundmeier, G., & Keller, A. (2021). Nanoscale
Surface Topography Modulates hIAPP Aggregation Pathways at Solid–Liquid Interfaces.
International Journal of Molecular Sciences, 22, 5142. https://doi.org/10.3390/ijms22105142
bibtex: '@article{Hanke_Yang_Ji_Grundmeier_Keller_2021, title={Nanoscale Surface
Topography Modulates hIAPP Aggregation Pathways at Solid–Liquid Interfaces}, volume={22},
DOI={10.3390/ijms22105142},
journal={International Journal of Molecular Sciences}, author={Hanke, Marcel and
Yang, Yu and Ji, Yuxin and Grundmeier, Guido and Keller, Adrian}, year={2021},
pages={5142} }'
chicago: 'Hanke, Marcel, Yu Yang, Yuxin Ji, Guido Grundmeier, and Adrian Keller.
“Nanoscale Surface Topography Modulates HIAPP Aggregation Pathways at Solid–Liquid
Interfaces.” International Journal of Molecular Sciences 22 (2021): 5142.
https://doi.org/10.3390/ijms22105142.'
ieee: M. Hanke, Y. Yang, Y. Ji, G. Grundmeier, and A. Keller, “Nanoscale Surface
Topography Modulates hIAPP Aggregation Pathways at Solid–Liquid Interfaces,” International
Journal of Molecular Sciences, vol. 22, p. 5142, 2021.
mla: Hanke, Marcel, et al. “Nanoscale Surface Topography Modulates HIAPP Aggregation
Pathways at Solid–Liquid Interfaces.” International Journal of Molecular Sciences,
vol. 22, 2021, p. 5142, doi:10.3390/ijms22105142.
short: M. Hanke, Y. Yang, Y. Ji, G. Grundmeier, A. Keller, International Journal
of Molecular Sciences 22 (2021) 5142.
date_created: 2021-07-08T11:43:14Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.3390/ijms22105142
intvolume: ' 22'
language:
- iso: eng
page: '5142'
publication: International Journal of Molecular Sciences
publication_identifier:
issn:
- 1422-0067
publication_status: published
status: public
title: Nanoscale Surface Topography Modulates hIAPP Aggregation Pathways at Solid–Liquid
Interfaces
type: journal_article
user_id: '48864'
volume: 22
year: '2021'
...
---
_id: '22637'
abstract:
- lang: eng
text: "Abstract\r\n Doxorubicin (DOX)
is a common drug in cancer chemotherapy, and its high DNA-binding affinity can
be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery
and therapeutics. Although DOX has been widely studied, the existing literature
of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth
spectroscopic analysis, we characterize and optimize the DOX loading into different
2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions,
all DONs show similar DOX binding capacities (one DOX molecule per two to three
base pairs), and the binding equilibrium is reached within seconds, remarkably
faster than previously acknowledged. To characterize drug release profiles, DON
degradation and DOX release from the complexes upon DNase I digestion was studied.
For the employed DONs, the relative doses (DOX molecules released per unit time)
may vary by two orders of magnitude depending on the DON superstructure. In addition,
we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium,
and DOX concentration. These features have been largely ignored in experimenting
with DNA nanostructures, but are probably the major sources of the incoherence
of the experimental results so far. Therefore, we believe this work can act as
a guide to tailoring the release profiles and developing better drug delivery
systems based on DNA-carriers."
author:
- first_name: Heini
full_name: Ijäs, Heini
last_name: Ijäs
- first_name: Boxuan
full_name: Shen, Boxuan
last_name: Shen
- first_name: Amelie
full_name: Heuer-Jungemann, Amelie
last_name: Heuer-Jungemann
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: Mauri A
full_name: Kostiainen, Mauri A
last_name: Kostiainen
- first_name: Tim
full_name: Liedl, Tim
last_name: Liedl
- first_name: Janne A
full_name: Ihalainen, Janne A
last_name: Ihalainen
- first_name: Veikko
full_name: Linko, Veikko
last_name: Linko
citation:
ama: Ijäs H, Shen B, Heuer-Jungemann A, et al. Unraveling the interaction between
doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug
release. Nucleic Acids Research. 2021;49:3048-3062. doi:10.1093/nar/gkab097
apa: Ijäs, H., Shen, B., Heuer-Jungemann, A., Keller, A., Kostiainen, M. A., Liedl,
T., … Linko, V. (2021). Unraveling the interaction between doxorubicin and DNA
origami nanostructures for customizable chemotherapeutic drug release. Nucleic
Acids Research, 49, 3048–3062. https://doi.org/10.1093/nar/gkab097
bibtex: '@article{Ijäs_Shen_Heuer-Jungemann_Keller_Kostiainen_Liedl_Ihalainen_Linko_2021,
title={Unraveling the interaction between doxorubicin and DNA origami nanostructures
for customizable chemotherapeutic drug release}, volume={49}, DOI={10.1093/nar/gkab097},
journal={Nucleic Acids Research}, author={Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann,
Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen,
Janne A and Linko, Veikko}, year={2021}, pages={3048–3062} }'
chicago: 'Ijäs, Heini, Boxuan Shen, Amelie Heuer-Jungemann, Adrian Keller, Mauri A
Kostiainen, Tim Liedl, Janne A Ihalainen, and Veikko Linko. “Unraveling the Interaction
between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic
Drug Release.” Nucleic Acids Research 49 (2021): 3048–62. https://doi.org/10.1093/nar/gkab097.'
ieee: H. Ijäs et al., “Unraveling the interaction between doxorubicin and
DNA origami nanostructures for customizable chemotherapeutic drug release,” Nucleic
Acids Research, vol. 49, pp. 3048–3062, 2021.
mla: Ijäs, Heini, et al. “Unraveling the Interaction between Doxorubicin and DNA
Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” Nucleic
Acids Research, vol. 49, 2021, pp. 3048–62, doi:10.1093/nar/gkab097.
short: H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M.A. Kostiainen, T. Liedl,
J.A. Ihalainen, V. Linko, Nucleic Acids Research 49 (2021) 3048–3062.
date_created: 2021-07-08T11:46:53Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1093/nar/gkab097
intvolume: ' 49'
language:
- iso: eng
page: 3048-3062
publication: Nucleic Acids Research
publication_identifier:
issn:
- 0305-1048
- 1362-4962
publication_status: published
status: public
title: Unraveling the interaction between doxorubicin and DNA origami nanostructures
for customizable chemotherapeutic drug release
type: journal_article
user_id: '48864'
volume: 49
year: '2021'
...
---
_id: '22638'
author:
- first_name: Y
full_name: Xin, Y
last_name: Xin
- first_name: B
full_name: Shen, B
last_name: Shen
- first_name: MA
full_name: Kostiainen, MA
last_name: Kostiainen
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: M
full_name: Castro, M
last_name: Castro
- first_name: V
full_name: Linko, V
last_name: Linko
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Xin Y, Shen B, Kostiainen M, et al. Scaling Up DNA Origami Lattice Assembly.
Chemistry – A European Journal. 2021;27(33):8564-8571. doi:10.1002/chem.202100784
apa: Xin, Y., Shen, B., Kostiainen, M., Grundmeier, G., Castro, M., Linko, V., &
Keller, A. (2021). Scaling Up DNA Origami Lattice Assembly. Chemistry – A European
Journal, 27(33), 8564–8571. https://doi.org/10.1002/chem.202100784
bibtex: '@article{Xin_Shen_Kostiainen_Grundmeier_Castro_Linko_Keller_2021, title={Scaling
Up DNA Origami Lattice Assembly.}, volume={27}, DOI={10.1002/chem.202100784},
number={33}, journal={Chemistry – A European Journal}, author={Xin, Y and Shen,
B and Kostiainen, MA and Grundmeier, Guido and Castro, M and Linko, V and Keller,
Adrian}, year={2021}, pages={8564–8571} }'
chicago: 'Xin, Y, B Shen, MA Kostiainen, Guido Grundmeier, M Castro, V Linko, and
Adrian Keller. “Scaling Up DNA Origami Lattice Assembly.” Chemistry – A European
Journal 27, no. 33 (2021): 8564–71. https://doi.org/10.1002/chem.202100784.'
ieee: Y. Xin et al., “Scaling Up DNA Origami Lattice Assembly.,” Chemistry
– A European Journal, vol. 27, no. 33, pp. 8564–8571, 2021.
mla: Xin, Y., et al. “Scaling Up DNA Origami Lattice Assembly.” Chemistry – A
European Journal, vol. 27, no. 33, 2021, pp. 8564–71, doi:10.1002/chem.202100784.
short: Y. Xin, B. Shen, M. Kostiainen, G. Grundmeier, M. Castro, V. Linko, A. Keller,
Chemistry – A European Journal 27 (2021) 8564–8571.
date_created: 2021-07-08T11:48:08Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1002/chem.202100784
external_id:
pmid:
- '33780583'
intvolume: ' 27'
issue: '33'
language:
- iso: eng
page: 8564-8571
pmid: '1'
publication: Chemistry – A European Journal
publication_identifier:
issn:
- 0947-6539
- 1521-3765
status: public
title: Scaling Up DNA Origami Lattice Assembly.
type: journal_article
user_id: '48864'
volume: 27
year: '2021'
...
---
_id: '22639'
author:
- first_name: Y
full_name: Yang, Y
last_name: Yang
- first_name: S
full_name: Knust, S
last_name: Knust
- first_name: S
full_name: Schwiderek, S
last_name: Schwiderek
- first_name: Q
full_name: Qin, Q
last_name: Qin
- first_name: Q
full_name: Yun, Q
last_name: Yun
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: 'Yang Y, Knust S, Schwiderek S, et al. Protein Adsorption at Nanorough Titanium
Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface
Roughness. Nanomaterials. 2021;11(2):357. doi:10.3390/nano11020357'
apa: 'Yang, Y., Knust, S., Schwiderek, S., Qin, Q., Yun, Q., Grundmeier, G., &
Keller, A. (2021). Protein Adsorption at Nanorough Titanium Oxide Surfaces: The
Importance of Surface Statistical Parameters beyond Surface Roughness. Nanomaterials,
11(2), 357. https://doi.org/10.3390/nano11020357'
bibtex: '@article{Yang_Knust_Schwiderek_Qin_Yun_Grundmeier_Keller_2021, title={Protein
Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical
Parameters beyond Surface Roughness.}, volume={11}, DOI={10.3390/nano11020357},
number={2}, journal={Nanomaterials}, author={Yang, Y and Knust, S and Schwiderek,
S and Qin, Q and Yun, Q and Grundmeier, Guido and Keller, Adrian}, year={2021},
pages={357} }'
chicago: 'Yang, Y, S Knust, S Schwiderek, Q Qin, Q Yun, Guido Grundmeier, and Adrian
Keller. “Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance
of Surface Statistical Parameters beyond Surface Roughness.” Nanomaterials
11, no. 2 (2021): 357. https://doi.org/10.3390/nano11020357.'
ieee: 'Y. Yang et al., “Protein Adsorption at Nanorough Titanium Oxide Surfaces:
The Importance of Surface Statistical Parameters beyond Surface Roughness.,” Nanomaterials,
vol. 11, no. 2, p. 357, 2021.'
mla: 'Yang, Y., et al. “Protein Adsorption at Nanorough Titanium Oxide Surfaces:
The Importance of Surface Statistical Parameters beyond Surface Roughness.” Nanomaterials,
vol. 11, no. 2, 2021, p. 357, doi:10.3390/nano11020357.'
short: Y. Yang, S. Knust, S. Schwiderek, Q. Qin, Q. Yun, G. Grundmeier, A. Keller,
Nanomaterials 11 (2021) 357.
date_created: 2021-07-08T11:50:44Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.3390/nano11020357
external_id:
pmid:
- '33535535'
intvolume: ' 11'
issue: '2'
language:
- iso: eng
page: ' 357 '
pmid: '1'
publication: Nanomaterials
publication_identifier:
issn:
- 2079-4991
status: public
title: 'Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of
Surface Statistical Parameters beyond Surface Roughness.'
type: journal_article
user_id: '48864'
volume: 11
year: '2021'
...
---
_id: '22640'
author:
- first_name: Petteri
full_name: Piskunen, Petteri
last_name: Piskunen
- first_name: Boxuan
full_name: Shen, Boxuan
last_name: Shen
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: J. Jussi
full_name: Toppari, J. Jussi
last_name: Toppari
- first_name: Mauri A.
full_name: Kostiainen, Mauri A.
last_name: Kostiainen
- first_name: Veikko
full_name: Linko, Veikko
last_name: Linko
citation:
ama: Piskunen P, Shen B, Keller A, Toppari JJ, Kostiainen MA, Linko V. Biotemplated
Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional
Materials. ACS Applied Nano Materials. 2021;4:529-538. doi:10.1021/acsanm.0c02849
apa: Piskunen, P., Shen, B., Keller, A., Toppari, J. J., Kostiainen, M. A., &
Linko, V. (2021). Biotemplated Lithography of Inorganic Nanostructures (BLIN)
for Versatile Patterning of Functional Materials. ACS Applied Nano Materials,
4, 529–538. https://doi.org/10.1021/acsanm.0c02849
bibtex: '@article{Piskunen_Shen_Keller_Toppari_Kostiainen_Linko_2021, title={Biotemplated
Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional
Materials}, volume={4}, DOI={10.1021/acsanm.0c02849},
journal={ACS Applied Nano Materials}, author={Piskunen, Petteri and Shen, Boxuan
and Keller, Adrian and Toppari, J. Jussi and Kostiainen, Mauri A. and Linko, Veikko},
year={2021}, pages={529–538} }'
chicago: 'Piskunen, Petteri, Boxuan Shen, Adrian Keller, J. Jussi Toppari, Mauri
A. Kostiainen, and Veikko Linko. “Biotemplated Lithography of Inorganic Nanostructures
(BLIN) for Versatile Patterning of Functional Materials.” ACS Applied Nano
Materials 4 (2021): 529–38. https://doi.org/10.1021/acsanm.0c02849.'
ieee: P. Piskunen, B. Shen, A. Keller, J. J. Toppari, M. A. Kostiainen, and V. Linko,
“Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning
of Functional Materials,” ACS Applied Nano Materials, vol. 4, pp. 529–538,
2021.
mla: Piskunen, Petteri, et al. “Biotemplated Lithography of Inorganic Nanostructures
(BLIN) for Versatile Patterning of Functional Materials.” ACS Applied Nano
Materials, vol. 4, 2021, pp. 529–38, doi:10.1021/acsanm.0c02849.
short: P. Piskunen, B. Shen, A. Keller, J.J. Toppari, M.A. Kostiainen, V. Linko,
ACS Applied Nano Materials 4 (2021) 529–538.
date_created: 2021-07-08T11:51:39Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1021/acsanm.0c02849
intvolume: ' 4'
language:
- iso: eng
page: 529-538
publication: ACS Applied Nano Materials
publication_identifier:
issn:
- 2574-0970
- 2574-0970
publication_status: published
status: public
title: Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning
of Functional Materials
type: journal_article
user_id: '48864'
volume: 4
year: '2021'
...
---
_id: '22641'
author:
- first_name: DM
full_name: Smith, DM
last_name: Smith
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Smith D, Keller A. DNA Nanostructures in the Fight Against Infectious Diseases.
Advanced NanoBiomed Research. 2021;1:2000049. doi:10.1002/anbr.202000049
apa: Smith, D., & Keller, A. (2021). DNA Nanostructures in the Fight Against
Infectious Diseases. Advanced NanoBiomed Research, 1, 2000049. https://doi.org/10.1002/anbr.202000049
bibtex: '@article{Smith_Keller_2021, title={DNA Nanostructures in the Fight Against
Infectious Diseases.}, volume={1}, DOI={10.1002/anbr.202000049},
journal={Advanced NanoBiomed Research}, author={Smith, DM and Keller, Adrian},
year={2021}, pages={2000049} }'
chicago: 'Smith, DM, and Adrian Keller. “DNA Nanostructures in the Fight Against
Infectious Diseases.” Advanced NanoBiomed Research 1 (2021): 2000049. https://doi.org/10.1002/anbr.202000049.'
ieee: D. Smith and A. Keller, “DNA Nanostructures in the Fight Against Infectious
Diseases.,” Advanced NanoBiomed Research, vol. 1, p. 2000049, 2021.
mla: Smith, DM, and Adrian Keller. “DNA Nanostructures in the Fight Against Infectious
Diseases.” Advanced NanoBiomed Research, vol. 1, 2021, p. 2000049, doi:10.1002/anbr.202000049.
short: D. Smith, A. Keller, Advanced NanoBiomed Research 1 (2021) 2000049.
date_created: 2021-07-08T11:53:25Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1002/anbr.202000049
external_id:
pmid:
- '33615315'
intvolume: ' 1'
language:
- iso: eng
page: '2000049'
pmid: '1'
publication: Advanced NanoBiomed Research
publication_identifier:
issn:
- 2699-9307
status: public
title: DNA Nanostructures in the Fight Against Infectious Diseases.
type: journal_article
user_id: '48864'
volume: 1
year: '2021'
...
---
_id: '22642'
author:
- first_name: Y
full_name: Xin, Y
last_name: Xin
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Xin Y, Grundmeier G, Keller A. Adsorption of SARS-CoV-2 Spike Protein S1 at
Oxide Surfaces Studied by High-Speed Atomic Force Microscopy. Advanced NanoBiomed
Research. 2021;1(2):2170023. doi:10.1002/anbr.202170023
apa: Xin, Y., Grundmeier, G., & Keller, A. (2021). Adsorption of SARS-CoV-2
Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.
Advanced NanoBiomed Research, 1(2), 2170023. https://doi.org/10.1002/anbr.202170023
bibtex: '@article{Xin_Grundmeier_Keller_2021, title={Adsorption of SARS-CoV-2 Spike
Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.},
volume={1}, DOI={10.1002/anbr.202170023},
number={2}, journal={Advanced NanoBiomed Research}, author={Xin, Y and Grundmeier,
Guido and Keller, Adrian}, year={2021}, pages={2170023} }'
chicago: 'Xin, Y, Guido Grundmeier, and Adrian Keller. “Adsorption of SARS-CoV-2
Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.”
Advanced NanoBiomed Research 1, no. 2 (2021): 2170023. https://doi.org/10.1002/anbr.202170023.'
ieee: Y. Xin, G. Grundmeier, and A. Keller, “Adsorption of SARS-CoV-2 Spike Protein
S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.,” Advanced
NanoBiomed Research, vol. 1, no. 2, p. 2170023, 2021.
mla: Xin, Y., et al. “Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces
Studied by High-Speed Atomic Force Microscopy.” Advanced NanoBiomed Research,
vol. 1, no. 2, 2021, p. 2170023, doi:10.1002/anbr.202170023.
short: Y. Xin, G. Grundmeier, A. Keller, Advanced NanoBiomed Research 1 (2021) 2170023.
date_created: 2021-07-08T11:54:36Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1002/anbr.202170023
external_id:
pmid:
- '33786537'
intvolume: ' 1'
issue: '2'
language:
- iso: eng
page: '2170023'
pmid: '1'
publication: Advanced NanoBiomed Research
publication_identifier:
issn:
- 2699-9307
status: public
title: Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed
Atomic Force Microscopy.
type: journal_article
user_id: '48864'
volume: 1
year: '2021'
...
---
_id: '22643'
author:
- first_name: Yu
full_name: Yang, Yu
last_name: Yang
- first_name: Mingrui
full_name: Yu, Mingrui
last_name: Yu
- first_name: Frederik
full_name: Böke, Frederik
last_name: Böke
- first_name: Qin
full_name: Qin, Qin
last_name: Qin
- first_name: René
full_name: Hübner, René
last_name: Hübner
- first_name: Steffen
full_name: Knust, Steffen
last_name: Knust
- first_name: Sabrina
full_name: Schwiderek, Sabrina
last_name: Schwiderek
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Horst
full_name: Fischer, Horst
last_name: Fischer
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Yang Y, Yu M, Böke F, et al. Effect of nanoscale surface topography on the
adsorption of globular proteins. Applied Surface Science. 2021;535:147671.
doi:10.1016/j.apsusc.2020.147671
apa: Yang, Y., Yu, M., Böke, F., Qin, Q., Hübner, R., Knust, S., … Keller, A. (2021).
Effect of nanoscale surface topography on the adsorption of globular proteins.
Applied Surface Science, 535, 147671. https://doi.org/10.1016/j.apsusc.2020.147671
bibtex: '@article{Yang_Yu_Böke_Qin_Hübner_Knust_Schwiderek_Grundmeier_Fischer_Keller_2021,
title={Effect of nanoscale surface topography on the adsorption of globular proteins},
volume={535}, DOI={10.1016/j.apsusc.2020.147671},
journal={Applied Surface Science}, author={Yang, Yu and Yu, Mingrui and Böke,
Frederik and Qin, Qin and Hübner, René and Knust, Steffen and Schwiderek, Sabrina
and Grundmeier, Guido and Fischer, Horst and Keller, Adrian}, year={2021}, pages={147671}
}'
chicago: 'Yang, Yu, Mingrui Yu, Frederik Böke, Qin Qin, René Hübner, Steffen Knust,
Sabrina Schwiderek, Guido Grundmeier, Horst Fischer, and Adrian Keller. “Effect
of Nanoscale Surface Topography on the Adsorption of Globular Proteins.” Applied
Surface Science 535 (2021): 147671. https://doi.org/10.1016/j.apsusc.2020.147671.'
ieee: Y. Yang et al., “Effect of nanoscale surface topography on the adsorption
of globular proteins,” Applied Surface Science, vol. 535, p. 147671, 2021.
mla: Yang, Yu, et al. “Effect of Nanoscale Surface Topography on the Adsorption
of Globular Proteins.” Applied Surface Science, vol. 535, 2021, p. 147671,
doi:10.1016/j.apsusc.2020.147671.
short: Y. Yang, M. Yu, F. Böke, Q. Qin, R. Hübner, S. Knust, S. Schwiderek, G. Grundmeier,
H. Fischer, A. Keller, Applied Surface Science 535 (2021) 147671.
date_created: 2021-07-08T11:57:33Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1016/j.apsusc.2020.147671
intvolume: ' 535'
language:
- iso: eng
page: '147671'
publication: Applied Surface Science
publication_identifier:
issn:
- 0169-4332
publication_status: published
status: public
title: Effect of nanoscale surface topography on the adsorption of globular proteins
type: journal_article
user_id: '48864'
volume: 535
year: '2021'
...
---
_id: '22773'
abstract:
- lang: eng
text: Ion beam irradiation of solid surfaces may result in the self-organized
formation of well-defined topographic nanopatterns. Depending on the irradiation
conditions and the material properties, isotropic or anisotropic patterns of differently
shaped features may be obtained. Most intriguingly, the periodicities of these
patterns can be adjusted in the range between less than twenty and several hundred
nanometers, which covers the dimensions of many cellular and extracellular features.
However, even though ion beam nanopatterning has been studied for several decades
and is nowadays widely employed in the fabrication of functional surfaces, it
has found its way into the biomaterials field only recently. This review provides
a brief overview of the basics of ion beam nanopatterning, emphasizes aspects
of particular relevance for biomaterials applications, and summarizes a number
of recent studies that investigated the effects of such nanopatterned surfaces
on the adsorption of biomolecules and the response of adhering cells. Finally,
promising future directions and potential translational challenges are identified.
author:
- first_name: Yu
full_name: Yang, Yu
last_name: Yang
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Yang Y, Keller A. Ion Beam Nanopatterning of Biomaterial Surfaces. Applied
Sciences. 2021;11:6575. doi:10.3390/app11146575
apa: Yang, Y., & Keller, A. (2021). Ion Beam Nanopatterning of Biomaterial Surfaces.
Applied Sciences, 11, 6575. https://doi.org/10.3390/app11146575
bibtex: '@article{Yang_Keller_2021, title={Ion Beam Nanopatterning of Biomaterial
Surfaces}, volume={11}, DOI={10.3390/app11146575},
journal={Applied Sciences}, author={Yang, Yu and Keller, Adrian}, year={2021},
pages={6575} }'
chicago: 'Yang, Yu, and Adrian Keller. “Ion Beam Nanopatterning of Biomaterial Surfaces.”
Applied Sciences 11 (2021): 6575. https://doi.org/10.3390/app11146575.'
ieee: Y. Yang and A. Keller, “Ion Beam Nanopatterning of Biomaterial Surfaces,”
Applied Sciences, vol. 11, p. 6575, 2021.
mla: Yang, Yu, and Adrian Keller. “Ion Beam Nanopatterning of Biomaterial Surfaces.”
Applied Sciences, vol. 11, 2021, p. 6575, doi:10.3390/app11146575.
short: Y. Yang, A. Keller, Applied Sciences 11 (2021) 6575.
date_created: 2021-07-21T09:25:55Z
date_updated: 2022-01-06T06:55:40Z
department:
- _id: '302'
doi: 10.3390/app11146575
intvolume: ' 11'
language:
- iso: eng
page: '6575'
publication: Applied Sciences
publication_identifier:
issn:
- 2076-3417
publication_status: published
status: public
title: Ion Beam Nanopatterning of Biomaterial Surfaces
type: journal_article
user_id: '48864'
volume: 11
year: '2021'
...
---
_id: '22926'
abstract:
- lang: eng
text: Implant-associated infections are an increasingly severe burden on
healthcare systems worldwide and many research activities currently focus on inhibiting
microbial colonization of biomedically relevant surfaces. To obtain molecular-level
understanding of the involved processes and interactions, we investigate the adsorption
of synthetic adhesin-like peptide sequences derived from the type IV pili of the
Pseudomonas aeruginosa strains PAK and PAO at abiotic model surfaces, i.e., Au,
SiO2, and oxidized Ti. These peptides correspond to the sequences of the receptor-binding
domain 128–144 of the major pilin protein, which is known to facilitate P. aeruginosa
adhesion at biotic and abiotic surfaces. Using quartz crystal microbalance with
dissipation monitoring (QCM-D), we find that peptide adsorption is material- as
well as strain-dependent. At the Au surface, PAO(128–144) shows drastically stronger
adsorption than PAK(128–144), whereas adsorption of both peptides is markedly
reduced at the oxide surfaces with less drastic differences between the two sequences.
These observations suggest that peptide adsorption is influenced by not only the
peptide sequence, but also peptide conformation. Our results furthermore highlight
the importance of molecular-level investigations to understand and ultimately
control microbial colonization of surfaces.
author:
- first_name: Yu
full_name: Yang, Yu
last_name: Yang
- first_name: Sabrina
full_name: Schwiderek, Sabrina
last_name: Schwiderek
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Yang Y, Schwiderek S, Grundmeier G, Keller A. Strain-Dependent Adsorption of
Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. Micro.
2021;1(1):129-139. doi:10.3390/micro1010010
apa: Yang, Y., Schwiderek, S., Grundmeier, G., & Keller, A. (2021). Strain-Dependent
Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic
Surfaces. Micro, 1(1), 129–139. https://doi.org/10.3390/micro1010010
bibtex: '@article{Yang_Schwiderek_Grundmeier_Keller_2021, title={Strain-Dependent
Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic
Surfaces}, volume={1}, DOI={10.3390/micro1010010},
number={1}, journal={Micro}, author={Yang, Yu and Schwiderek, Sabrina and Grundmeier,
Guido and Keller, Adrian}, year={2021}, pages={129–139} }'
chicago: 'Yang, Yu, Sabrina Schwiderek, Guido Grundmeier, and Adrian Keller. “Strain-Dependent
Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic
Surfaces.” Micro 1, no. 1 (2021): 129–39. https://doi.org/10.3390/micro1010010.'
ieee: Y. Yang, S. Schwiderek, G. Grundmeier, and A. Keller, “Strain-Dependent Adsorption
of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces,”
Micro, vol. 1, no. 1, pp. 129–139, 2021.
mla: Yang, Yu, et al. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived
Adhesin-like Peptides at Abiotic Surfaces.” Micro, vol. 1, no. 1, 2021,
pp. 129–39, doi:10.3390/micro1010010.
short: Y. Yang, S. Schwiderek, G. Grundmeier, A. Keller, Micro 1 (2021) 129–139.
date_created: 2021-08-03T06:07:33Z
date_updated: 2022-01-06T06:55:43Z
department:
- _id: '302'
doi: 10.3390/micro1010010
intvolume: ' 1'
issue: '1'
language:
- iso: eng
page: 129-139
publication: Micro
publication_identifier:
issn:
- 2673-8023
publication_status: published
status: public
title: Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like
Peptides at Abiotic Surfaces
type: journal_article
user_id: '48864'
volume: 1
year: '2021'
...
---
_id: '23023'
abstract:
- lang: eng
text: DNA origami nanostructures (DONs) are promising substrates for the
single-molecule investigation of biomolecular reactions and dynamics by in situ
atomic force microscopy (AFM). For this, they are typically immobilized on mica
substrates by adding millimolar concentrations of Mg2+ ions to the sample solution,
which enable the adsorption of the negatively charged DONs at the like-charged
mica surface. These non-physiological Mg2+ concentrations, however, present a
serious limitation in such experiments as they may interfere with the reactions
and processes under investigation. Therefore, we here evaluate three approaches
to efficiently immobilize DONs at mica surfaces under essentially Mg2+-free conditions.
These approaches rely on the pre-adsorption of different multivalent cations,
i.e., Ni2+, poly-l-lysine (PLL), and spermidine (Spdn). DON adsorption is studied
in phosphate-buffered saline (PBS) and pure water. In general, Ni2+ shows the
worst performance with heavily deformed DONs. For 2D DON triangles, adsorption
at PLL- and in particular Spdn-modified mica may outperform even Mg2+-mediated
adsorption in terms of surface coverage, depending on the employed solution. For
3D six-helix bundles, less pronounced differences between the individual strategies
are observed. Our results provide some general guidance for the immobilization
of DONs at mica surfaces under Mg2+-free conditions and may aid future in situ
AFM studies.
author:
- first_name: Yang
full_name: Xin, Yang
last_name: Xin
- first_name: Amir Ardalan
full_name: Zargariantabrizi, Amir Ardalan
last_name: Zargariantabrizi
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Xin Y, Zargariantabrizi AA, Grundmeier G, Keller A. Magnesium-Free Immobilization
of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy. Molecules.
2021;26:4798. doi:10.3390/molecules26164798
apa: Xin, Y., Zargariantabrizi, A. A., Grundmeier, G., & Keller, A. (2021).
Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for
Atomic Force Microscopy. Molecules, 26, 4798. https://doi.org/10.3390/molecules26164798
bibtex: '@article{Xin_Zargariantabrizi_Grundmeier_Keller_2021, title={Magnesium-Free
Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force
Microscopy}, volume={26}, DOI={10.3390/molecules26164798},
journal={Molecules}, author={Xin, Yang and Zargariantabrizi, Amir Ardalan and
Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={4798} }'
chicago: 'Xin, Yang, Amir Ardalan Zargariantabrizi, Guido Grundmeier, and Adrian
Keller. “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces
for Atomic Force Microscopy.” Molecules 26 (2021): 4798. https://doi.org/10.3390/molecules26164798.'
ieee: Y. Xin, A. A. Zargariantabrizi, G. Grundmeier, and A. Keller, “Magnesium-Free
Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force
Microscopy,” Molecules, vol. 26, p. 4798, 2021.
mla: Xin, Yang, et al. “Magnesium-Free Immobilization of DNA Origami Nanostructures
at Mica Surfaces for Atomic Force Microscopy.” Molecules, vol. 26, 2021,
p. 4798, doi:10.3390/molecules26164798.
short: Y. Xin, A.A. Zargariantabrizi, G. Grundmeier, A. Keller, Molecules 26 (2021)
4798.
date_created: 2021-08-09T06:17:59Z
date_updated: 2022-01-06T06:55:45Z
department:
- _id: '302'
doi: 10.3390/molecules26164798
intvolume: ' 26'
language:
- iso: eng
page: '4798'
publication: Molecules
publication_identifier:
issn:
- 1420-3049
publication_status: published
status: public
title: Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces
for Atomic Force Microscopy
type: journal_article
user_id: '48864'
volume: 26
year: '2021'
...
---
_id: '22635'
abstract:
- lang: eng
text: Photodynamic therapy (PDT) using TiO2 nanoparticles has become an important
alternative treatment for different types of cancer due to their high photocatalytic
activity and high absorption of UV-A light. To potentiate this treatment, we have
coated commercial glass plates with TiO2 nanoparticles prepared by the sol–gel
method (TiO2-m), which exhibit a remarkable selectivity for the irreversible trapping
of cancer cells. The physicochemical properties of the deposited TiO2-m nanoparticle
coatings have been characterized by a number of complementary surface-analytical
techniques and their interaction with leukemia and healthy blood cells were investigated.
Scanning electron and atomic force microscopy verify the formation of a compact
layer of TiO2-m nanoparticles. The particles are predominantly in the anatase
phase and have hydroxyl-terminated surfaces as revealed by Raman, X-ray photoelectron,
and infrared spectroscopy, as well as X-ray diffraction. We find that lymphoblastic
leukemia cells adhere to the TiO2-m coating and undergo amoeboid-like migration,
whereas lymphocytic cells show distinctly weaker interactions with the coating.
This evidences the potential of this nanomaterial coating to selectively trap
cancer cells and renders it a promising candidate for the development of future
prototypes of PDT devices for the treatment of leukemia and other types of cancers
with non-adherent cells.
article_type: original
author:
- first_name: Jaime Andres
full_name: Garcia Diosa, Jaime Andres
last_name: Garcia Diosa
- first_name: Alejandro
full_name: Gonzalez Orive, Alejandro
last_name: Gonzalez Orive
- first_name: Christian
full_name: Weinberger, Christian
id: '11848'
last_name: Weinberger
- first_name: Sabrina
full_name: Schwiderek, Sabrina
last_name: Schwiderek
- first_name: Steffen
full_name: Knust, Steffen
last_name: Knust
- first_name: Michael
full_name: Tiemann, Michael
id: '23547'
last_name: Tiemann
orcid: 0000-0003-1711-2722
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
- first_name: Ruben Jesus
full_name: Camargo Amado, Ruben Jesus
last_name: Camargo Amado
citation:
ama: 'Garcia Diosa JA, Gonzalez Orive A, Weinberger C, et al. TiO2 nanoparticle
coatings on glass surfaces for the selective trapping of leukemia cells from peripheral
blood. Journal of Biomedical Materials Research Part B: Applied Biomaterials.
2021;109:2142–2153. doi:10.1002/jbm.b.34862'
apa: 'Garcia Diosa, J. A., Gonzalez Orive, A., Weinberger, C., Schwiderek, S., Knust,
S., Tiemann, M., Grundmeier, G., Keller, A., & Camargo Amado, R. J. (2021).
TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia
cells from peripheral blood. Journal of Biomedical Materials Research Part
B: Applied Biomaterials, 109, 2142–2153. https://doi.org/10.1002/jbm.b.34862'
bibtex: '@article{Garcia Diosa_Gonzalez Orive_Weinberger_Schwiderek_Knust_Tiemann_Grundmeier_Keller_Camargo
Amado_2021, title={TiO2 nanoparticle coatings on glass surfaces for the selective
trapping of leukemia cells from peripheral blood}, volume={109}, DOI={10.1002/jbm.b.34862},
journal={Journal of Biomedical Materials Research Part B: Applied Biomaterials},
author={Garcia Diosa, Jaime Andres and Gonzalez Orive, Alejandro and Weinberger,
Christian and Schwiderek, Sabrina and Knust, Steffen and Tiemann, Michael and
Grundmeier, Guido and Keller, Adrian and Camargo Amado, Ruben Jesus}, year={2021},
pages={2142–2153} }'
chicago: 'Garcia Diosa, Jaime Andres, Alejandro Gonzalez Orive, Christian Weinberger,
Sabrina Schwiderek, Steffen Knust, Michael Tiemann, Guido Grundmeier, Adrian Keller,
and Ruben Jesus Camargo Amado. “TiO2 Nanoparticle Coatings on Glass Surfaces for
the Selective Trapping of Leukemia Cells from Peripheral Blood.” Journal of
Biomedical Materials Research Part B: Applied Biomaterials 109 (2021): 2142–2153.
https://doi.org/10.1002/jbm.b.34862.'
ieee: 'J. A. Garcia Diosa et al., “TiO2 nanoparticle coatings on glass surfaces
for the selective trapping of leukemia cells from peripheral blood,” Journal
of Biomedical Materials Research Part B: Applied Biomaterials, vol. 109, pp.
2142–2153, 2021, doi: 10.1002/jbm.b.34862.'
mla: 'Garcia Diosa, Jaime Andres, et al. “TiO2 Nanoparticle Coatings on Glass Surfaces
for the Selective Trapping of Leukemia Cells from Peripheral Blood.” Journal
of Biomedical Materials Research Part B: Applied Biomaterials, vol. 109, 2021,
pp. 2142–2153, doi:10.1002/jbm.b.34862.'
short: 'J.A. Garcia Diosa, A. Gonzalez Orive, C. Weinberger, S. Schwiderek, S. Knust,
M. Tiemann, G. Grundmeier, A. Keller, R.J. Camargo Amado, Journal of Biomedical
Materials Research Part B: Applied Biomaterials 109 (2021) 2142–2153.'
date_created: 2021-07-08T11:34:21Z
date_updated: 2023-03-08T08:10:25Z
department:
- _id: '302'
- _id: '307'
- _id: '35'
- _id: '2'
doi: 10.1002/jbm.b.34862
intvolume: ' 109'
language:
- iso: eng
page: 2142–2153
publication: 'Journal of Biomedical Materials Research Part B: Applied Biomaterials'
publication_identifier:
issn:
- 1552-4973
- 1552-4981
publication_status: published
quality_controlled: '1'
status: public
title: TiO2 nanoparticle coatings on glass surfaces for the selective trapping of
leukemia cells from peripheral blood
type: journal_article
user_id: '23547'
volume: 109
year: '2021'
...
---
_id: '22644'
abstract:
- lang: eng
text: The aggregation of human islet amyloid polypeptide (hIAPP) plays a
major role in the pathogenesis of type 2 diabetes mellitus (T2DM), and numerous
strategies for controlling hIAPP aggregation have been investigated so far. In
particular, several organic and inorganic nanoparticles (NPs) have shown the potential
to influence the aggregation of hIAPP and other amyloidogenic proteins and peptides.
In addition to conventional NPs, DNA nanostructures are receiving more and more
attention from the biomedical field. Therefore, in this work, we investigated
the effects of two different DNA origami nanostructures on hIAPP aggregation.
To this end, we employed in situ turbidity measurements and ex situ atomic force
microscopy (AFM). The turbidity measurements revealed a retarding effect of the
DNA nanostructures on hIAPP aggregation, while the AFM results showed the co-aggregation
of hIAPP with the DNA origami nanostructures into hybrid peptide–DNA aggregates.
We assume that this was caused by strong electrostatic interactions between the
negatively charged DNA origami nanostructures and the positively charged peptide.
Most intriguingly, the influence of the DNA origami nanostructures on hIAPP aggregation
differed from that of genomic double-stranded DNA (dsDNA) and appeared to depend
on DNA origami superstructure. DNA origami nanostructures may thus represent a
novel route for modulating amyloid aggregation in vivo.
author:
- first_name: Marcel
full_name: Hanke, Marcel
last_name: Hanke
- first_name: Alejandro
full_name: Gonzalez Orive, Alejandro
last_name: Gonzalez Orive
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Hanke M, Gonzalez Orive A, Grundmeier G, Keller A. Effect of DNA Origami Nanostructures
on hIAPP Aggregation. Nanomaterials. 2020;10:2200. doi:10.3390/nano10112200
apa: Hanke, M., Gonzalez Orive, A., Grundmeier, G., & Keller, A. (2020). Effect
of DNA Origami Nanostructures on hIAPP Aggregation. Nanomaterials, 10,
2200. https://doi.org/10.3390/nano10112200
bibtex: '@article{Hanke_Gonzalez Orive_Grundmeier_Keller_2020, title={Effect of
DNA Origami Nanostructures on hIAPP Aggregation}, volume={10}, DOI={10.3390/nano10112200},
journal={Nanomaterials}, author={Hanke, Marcel and Gonzalez Orive, Alejandro and
Grundmeier, Guido and Keller, Adrian}, year={2020}, pages={2200} }'
chicago: 'Hanke, Marcel, Alejandro Gonzalez Orive, Guido Grundmeier, and Adrian
Keller. “Effect of DNA Origami Nanostructures on HIAPP Aggregation.” Nanomaterials
10 (2020): 2200. https://doi.org/10.3390/nano10112200.'
ieee: M. Hanke, A. Gonzalez Orive, G. Grundmeier, and A. Keller, “Effect of DNA
Origami Nanostructures on hIAPP Aggregation,” Nanomaterials, vol. 10, p.
2200, 2020.
mla: Hanke, Marcel, et al. “Effect of DNA Origami Nanostructures on HIAPP Aggregation.”
Nanomaterials, vol. 10, 2020, p. 2200, doi:10.3390/nano10112200.
short: M. Hanke, A. Gonzalez Orive, G. Grundmeier, A. Keller, Nanomaterials 10 (2020)
2200.
date_created: 2021-07-08T11:59:01Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.3390/nano10112200
intvolume: ' 10'
language:
- iso: eng
page: '2200'
publication: Nanomaterials
publication_identifier:
issn:
- 2079-4991
publication_status: published
status: public
title: Effect of DNA Origami Nanostructures on hIAPP Aggregation
type: journal_article
user_id: '48864'
volume: 10
year: '2020'
...
---
_id: '22645'
abstract:
- lang: eng
text: Immobile Holliday junctions represent not only the most fundamental
building block of structural DNA nanotechnology but are also of tremendous importance
for the in vitro investigation of genetic recombination and epigenetics. Here,
we present a detailed study on the room-temperature assembly of immobile Holliday
junctions with the help of the single-strand annealing protein Redβ. Individual
DNA single strands are initially coated with protein monomers and subsequently
hybridized to form a rigid blunt-ended four-arm junction. We investigate the efficiency
of this approach for different DNA/protein ratios, as well as for different DNA
sequence lengths. Furthermore, we also evaluate the potential of Redβ to anneal
sticky-end modified Holliday junctions into hierarchical assemblies. We demonstrate
the Redβ-mediated annealing of Holliday junction dimers, multimers, and extended
networks several microns in size. While these hybrid DNA–protein nanostructures
may find applications in the crystallization of DNA–protein complexes, our work
shows the great potential of Redβ to aid in the synthesis of functional DNA nanostructures
under mild reaction conditions.
author:
- first_name: Saminathan
full_name: Ramakrishnan, Saminathan
last_name: Ramakrishnan
- first_name: Sivaraman
full_name: Subramaniam, Sivaraman
last_name: Subramaniam
- first_name: Charlotte
full_name: Kielar, Charlotte
last_name: Kielar
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: A. Francis
full_name: Stewart, A. Francis
last_name: Stewart
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Ramakrishnan S, Subramaniam S, Kielar C, Grundmeier G, Stewart AF, Keller A.
Protein-Assisted Room-Temperature Assembly of Rigid, Immobile Holliday Junctions
and Hierarchical DNA Nanostructures. Molecules. 2020;25:5099. doi:10.3390/molecules25215099
apa: Ramakrishnan, S., Subramaniam, S., Kielar, C., Grundmeier, G., Stewart, A.
F., & Keller, A. (2020). Protein-Assisted Room-Temperature Assembly of Rigid,
Immobile Holliday Junctions and Hierarchical DNA Nanostructures. Molecules,
25, 5099. https://doi.org/10.3390/molecules25215099
bibtex: '@article{Ramakrishnan_Subramaniam_Kielar_Grundmeier_Stewart_Keller_2020,
title={Protein-Assisted Room-Temperature Assembly of Rigid, Immobile Holliday
Junctions and Hierarchical DNA Nanostructures}, volume={25}, DOI={10.3390/molecules25215099},
journal={Molecules}, author={Ramakrishnan, Saminathan and Subramaniam, Sivaraman
and Kielar, Charlotte and Grundmeier, Guido and Stewart, A. Francis and Keller,
Adrian}, year={2020}, pages={5099} }'
chicago: 'Ramakrishnan, Saminathan, Sivaraman Subramaniam, Charlotte Kielar, Guido
Grundmeier, A. Francis Stewart, and Adrian Keller. “Protein-Assisted Room-Temperature
Assembly of Rigid, Immobile Holliday Junctions and Hierarchical DNA Nanostructures.”
Molecules 25 (2020): 5099. https://doi.org/10.3390/molecules25215099.'
ieee: S. Ramakrishnan, S. Subramaniam, C. Kielar, G. Grundmeier, A. F. Stewart,
and A. Keller, “Protein-Assisted Room-Temperature Assembly of Rigid, Immobile
Holliday Junctions and Hierarchical DNA Nanostructures,” Molecules, vol.
25, p. 5099, 2020.
mla: Ramakrishnan, Saminathan, et al. “Protein-Assisted Room-Temperature Assembly
of Rigid, Immobile Holliday Junctions and Hierarchical DNA Nanostructures.” Molecules,
vol. 25, 2020, p. 5099, doi:10.3390/molecules25215099.
short: S. Ramakrishnan, S. Subramaniam, C. Kielar, G. Grundmeier, A.F. Stewart,
A. Keller, Molecules 25 (2020) 5099.
date_created: 2021-07-08T11:59:55Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.3390/molecules25215099
intvolume: ' 25'
language:
- iso: eng
page: '5099'
publication: Molecules
publication_identifier:
issn:
- 1420-3049
publication_status: published
status: public
title: Protein-Assisted Room-Temperature Assembly of Rigid, Immobile Holliday Junctions
and Hierarchical DNA Nanostructures
type: journal_article
user_id: '48864'
volume: 25
year: '2020'
...