[{"volume":284,"author":[{"full_name":"Haerteis, Silke","last_name":"Haerteis","first_name":"Silke"},{"first_name":"Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger","full_name":"Krueger, Bettina","id":"49428"},{"last_name":"Korbmacher","full_name":"Korbmacher, Christoph","first_name":"Christoph"},{"first_name":"Robert","last_name":"Rauh","full_name":"Rauh, Robert"}],"date_created":"2024-06-30T13:58:07Z","publisher":"American Society for Biochemistry and Molecular Biology","date_updated":"2024-06-30T13:58:15Z","doi":"10.1074/jbc.m109.018945","title":"The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation","issue":"42","intvolume":"       284","page":"29024–29040","citation":{"ama":"Haerteis S, Krueger B, Korbmacher C, Rauh R. The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation. <i>Journal of Biological Chemistry</i>. 2009;284(42):29024–29040. doi:<a href=\"https://doi.org/10.1074/jbc.m109.018945\">10.1074/jbc.m109.018945</a>","chicago":"Haerteis, Silke, Bettina Krueger, Christoph Korbmacher, and Robert Rauh. “The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation.” <i>Journal of Biological Chemistry</i> 284, no. 42 (2009): 29024–29040. <a href=\"https://doi.org/10.1074/jbc.m109.018945\">https://doi.org/10.1074/jbc.m109.018945</a>.","ieee":"S. Haerteis, B. Krueger, C. Korbmacher, and R. Rauh, “The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation,” <i>Journal of Biological Chemistry</i>, vol. 284, no. 42, pp. 29024–29040, 2009, doi: <a href=\"https://doi.org/10.1074/jbc.m109.018945\">10.1074/jbc.m109.018945</a>.","bibtex":"@article{Haerteis_Krueger_Korbmacher_Rauh_2009, title={The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation}, volume={284}, DOI={<a href=\"https://doi.org/10.1074/jbc.m109.018945\">10.1074/jbc.m109.018945</a>}, number={42}, journal={Journal of Biological Chemistry}, publisher={American Society for Biochemistry and Molecular Biology}, author={Haerteis, Silke and Krueger, Bettina and Korbmacher, Christoph and Rauh, Robert}, year={2009}, pages={29024–29040} }","mla":"Haerteis, Silke, et al. “The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation.” <i>Journal of Biological Chemistry</i>, vol. 284, no. 42, American Society for Biochemistry and Molecular Biology, 2009, pp. 29024–29040, doi:<a href=\"https://doi.org/10.1074/jbc.m109.018945\">10.1074/jbc.m109.018945</a>.","short":"S. Haerteis, B. Krueger, C. Korbmacher, R. Rauh, Journal of Biological Chemistry 284 (2009) 29024–29040.","apa":"Haerteis, S., Krueger, B., Korbmacher, C., &#38; Rauh, R. (2009). The $\\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation. <i>Journal of Biological Chemistry</i>, <i>284</i>(42), 29024–29040. <a href=\"https://doi.org/10.1074/jbc.m109.018945\">https://doi.org/10.1074/jbc.m109.018945</a>"},"year":"2009","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","_id":"54944","language":[{"iso":"eng"}],"publication":"Journal of Biological Chemistry","type":"journal_article","status":"public","abstract":[{"text":"The epithelial sodium channel (ENaC) is probably a heterotrimer with three well characterized subunits (alphabetagamma). In humans an additional delta-subunit (delta-hENaC) exists but little is known about its function. Using the Xenopus laevis oocyte expression system, we compared the functional properties of alphabetagamma- and deltabetagamma-hENaC and investigated whether deltabetagamma-hENaC can be proteolytically activated. The amiloride-sensitive ENaC whole-cell current (DeltaI(ami)) was about 11-fold larger in oocytes expressing deltabetagamma-hENaC than in oocytes expressing alphabetagamma-hENaC. The 2-fold larger single-channel Na(+) conductance of deltabetagamma-hENaC cannot explain this difference. Using a chemiluminescence assay, we demonstrated that an increased channel surface expression is also not the cause. Thus, overall channel activity of deltabetagamma-hENaC must be higher than that of alphabetagamma-hENaC. Experiments exploiting the properties of the known betaS520C mutant ENaC confirmed this conclusion. Moreover, chymotrypsin had a reduced stimulatory effect on deltabetagamma-hENaC whole-cell currents compared with its effect on alphabetagamma-hENaC whole-cell currents (2-fold versus 5-fold). This suggests that the cell surface pool of so-called near-silent channels that can be proteolytically activated is smaller for deltabetagamma-hENaC than for alphabetagamma-hENaC. Proteolytic activation of deltabetagamma-hENaC was associated with the appearance of a delta-hENaC cleavage product at the cell surface. Finally, we demonstrated that a short inhibitory 13-mer peptide corresponding to a region of the extracellular loop of human alpha-ENaC inhibited DeltaI(ami) in oocytes expressing alphabetagamma-hENaC but not in those expressing deltabetagamma-hENaC. We conclude that the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity.","lang":"eng"}]},{"volume":24,"date_created":"2024-06-30T13:52:19Z","author":[{"first_name":"Bettina","full_name":"Krueger, Bettina","id":"49428","last_name":"Krueger","orcid":"0000-0001-5351-1785"},{"first_name":"Silke","full_name":"Haerteis, Silke","last_name":"Haerteis"},{"first_name":"Limin","full_name":"Yang, Limin","last_name":"Yang"},{"last_name":"Hartner","full_name":"Hartner, Andrea","first_name":"Andrea"},{"first_name":"Robert","last_name":"Rauh","full_name":"Rauh, Robert"},{"first_name":"Christoph","full_name":"Korbmacher, Christoph","last_name":"Korbmacher"},{"first_name":"Alexei","full_name":"Diakov, Alexei","last_name":"Diakov"}],"publisher":"S. Karger AG","date_updated":"2024-06-30T13:52:27Z","doi":"10.1159/000257516","title":"Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1","issue":"5-6","page":"605–618","intvolume":"        24","citation":{"ieee":"B. Krueger <i>et al.</i>, “Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1,” <i>Cellular Physiology and Biochemistry</i>, vol. 24, no. 5–6, pp. 605–618, 2009, doi: <a href=\"https://doi.org/10.1159/000257516\">10.1159/000257516</a>.","chicago":"Krueger, Bettina, Silke Haerteis, Limin Yang, Andrea Hartner, Robert Rauh, Christoph Korbmacher, and Alexei Diakov. “Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1.” <i>Cellular Physiology and Biochemistry</i> 24, no. 5–6 (2009): 605–618. <a href=\"https://doi.org/10.1159/000257516\">https://doi.org/10.1159/000257516</a>.","ama":"Krueger B, Haerteis S, Yang L, et al. Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1. <i>Cellular Physiology and Biochemistry</i>. 2009;24(5-6):605–618. doi:<a href=\"https://doi.org/10.1159/000257516\">10.1159/000257516</a>","mla":"Krueger, Bettina, et al. “Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1.” <i>Cellular Physiology and Biochemistry</i>, vol. 24, no. 5–6, S. Karger AG, 2009, pp. 605–618, doi:<a href=\"https://doi.org/10.1159/000257516\">10.1159/000257516</a>.","short":"B. Krueger, S. Haerteis, L. Yang, A. Hartner, R. Rauh, C. Korbmacher, A. Diakov, Cellular Physiology and Biochemistry 24 (2009) 605–618.","bibtex":"@article{Krueger_Haerteis_Yang_Hartner_Rauh_Korbmacher_Diakov_2009, title={Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1}, volume={24}, DOI={<a href=\"https://doi.org/10.1159/000257516\">10.1159/000257516</a>}, number={5–6}, journal={Cellular Physiology and Biochemistry}, publisher={S. Karger AG}, author={Krueger, Bettina and Haerteis, Silke and Yang, Limin and Hartner, Andrea and Rauh, Robert and Korbmacher, Christoph and Diakov, Alexei}, year={2009}, pages={605–618} }","apa":"Krueger, B., Haerteis, S., Yang, L., Hartner, A., Rauh, R., Korbmacher, C., &#38; Diakov, A. (2009). Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1. <i>Cellular Physiology and Biochemistry</i>, <i>24</i>(5–6), 605–618. <a href=\"https://doi.org/10.1159/000257516\">https://doi.org/10.1159/000257516</a>"},"year":"2009","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","_id":"54938","language":[{"iso":"eng"}],"publication":"Cellular Physiology and Biochemistry","type":"journal_article","status":"public","abstract":[{"text":"The lipid environment of the epithelial sodium channel (ENaC) and its possible association with so-called lipid rafts may be relevant to its function. The aim of our study was to confirm the association of ENaC with lipid rafts and to analyze the effect of cholesterol depletion of the plasma membrane by methyl-beta-cyclodextrin (MbetaCD) on channel function and regulation. Using sucrose density gradient centrifugation we demonstrated that a significant portion of ENaC protein distributes to low density fractions thought to be typical lipid raft fractions. Importantly, cholesterol depletion of cell lysate by MbetaCD shifted ENaC to non-raft fractions of higher density. Live cell imaging demonstrated that treatment with MbetaCD largely reduced filipin staining over time, confirming cholesterol depletion of the plasma membrane. For electrophysiological studies intact oocytes were exposed to 20 mM MbetaCD for three hours. MbetaCD treatment had no consistent effect on baseline whole-cell ENaC currents. In addition to the typical single channel conductance of about 5 pS, subconductance states of ENaC were occasionally observed in patches from MbetaCD treated but not from control oocytes. Importantly, in outside-out patch clamp recordings the stimulatory effect of recombinant SGK1 in the pipette solution was essentially abolished in oocytes pretreated with MbetaCD. These results indicate that ENaC activation by cytosolic SGK1 is compromised by removing cholesterol from the plasma membrane. Thus, ENaC activation by SGK1 may require the presence of an intact lipid environment and/or of lipid rafts as signalling platform.","lang":"eng"}]},{"doi":"10.1016/j.comnet.2008.09.007","title":"A Rule-based System for Programming Self-Organized Sensor and Actor Networks","date_created":"2024-06-30T13:58:42Z","author":[{"first_name":"Falko","last_name":"Dressler","full_name":"Dressler, Falko"},{"first_name":"Isabel","last_name":"Dietrich","full_name":"Dietrich, Isabel"},{"first_name":"Reinhard","full_name":"German, Reinhard","last_name":"German"},{"first_name":"Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger","id":"49428","full_name":"Krueger, Bettina"}],"volume":53,"date_updated":"2024-06-30T13:58:52Z","publisher":"Elsevier","citation":{"apa":"Dressler, F., Dietrich, I., German, R., &#38; Krueger, B. (2009). A Rule-based System for Programming Self-Organized Sensor and Actor Networks. <i>Elsevier Computer Networks</i>, <i>53</i>(10), 1737–1750. <a href=\"https://doi.org/10.1016/j.comnet.2008.09.007\">https://doi.org/10.1016/j.comnet.2008.09.007</a>","short":"F. Dressler, I. Dietrich, R. German, B. Krueger, Elsevier Computer Networks 53 (2009) 1737–1750.","mla":"Dressler, Falko, et al. “A Rule-Based System for Programming Self-Organized Sensor and Actor Networks.” <i>Elsevier Computer Networks</i>, vol. 53, no. 10, Elsevier, 2009, pp. 1737–1750, doi:<a href=\"https://doi.org/10.1016/j.comnet.2008.09.007\">10.1016/j.comnet.2008.09.007</a>.","bibtex":"@article{Dressler_Dietrich_German_Krueger_2009, title={A Rule-based System for Programming Self-Organized Sensor and Actor Networks}, volume={53}, DOI={<a href=\"https://doi.org/10.1016/j.comnet.2008.09.007\">10.1016/j.comnet.2008.09.007</a>}, number={10}, journal={Elsevier Computer Networks}, publisher={Elsevier}, author={Dressler, Falko and Dietrich, Isabel and German, Reinhard and Krueger, Bettina}, year={2009}, pages={1737–1750} }","chicago":"Dressler, Falko, Isabel Dietrich, Reinhard German, and Bettina Krueger. “A Rule-Based System for Programming Self-Organized Sensor and Actor Networks.” <i>Elsevier Computer Networks</i> 53, no. 10 (2009): 1737–1750. <a href=\"https://doi.org/10.1016/j.comnet.2008.09.007\">https://doi.org/10.1016/j.comnet.2008.09.007</a>.","ieee":"F. Dressler, I. Dietrich, R. German, and B. Krueger, “A Rule-based System for Programming Self-Organized Sensor and Actor Networks,” <i>Elsevier Computer Networks</i>, vol. 53, no. 10, pp. 1737–1750, 2009, doi: <a href=\"https://doi.org/10.1016/j.comnet.2008.09.007\">10.1016/j.comnet.2008.09.007</a>.","ama":"Dressler F, Dietrich I, German R, Krueger B. A Rule-based System for Programming Self-Organized Sensor and Actor Networks. <i>Elsevier Computer Networks</i>. 2009;53(10):1737–1750. doi:<a href=\"https://doi.org/10.1016/j.comnet.2008.09.007\">10.1016/j.comnet.2008.09.007</a>"},"page":"1737–1750","intvolume":"        53","year":"2009","issue":"10","publication_identifier":{"issn":["1389-1286"]},"language":[{"iso":"eng"}],"user_id":"49428","department":[{"_id":"35"},{"_id":"22"}],"_id":"54945","status":"public","abstract":[{"text":"We describe a programming scheme for massively distributed systems that are assumed to self-organize according to a given set of simple rules. The focus of this investigation is operation and control in Sensor and Actor Networks (SANETs). The main issues addressed by self-organization techniques are scalability, network lifetime, and real-time support. In the literature, biological principles are often cited as inspirations for technical solutions, especially in the domain of self-organization. We developed a system named Rule-based Sensor Network (RSN) according to the observed communication and control behavior in cellular communication. Cellular signaling cascades allow the event-specific reaction initiated by individual cells in collaboration with their direct neighbors. Information between cells are transmitted via proteins and result in the cascade of protein-protein or protein-DNA interactions to produce a specific cellular answer, e.g. the activation of cells or the transmission of mediators. These processes are programmed in every individual cell and lead to a coordinated reaction on a higher organization platform. We transferred these mechanisms to operation and control in SANETs. In particular, a rule-based processing scheme relying on the main concepts of cellular signaling cascades has been developed. It relies on simple local rules and provides problem specific reaction such as local actuation control and data manipulation. We describe this RSN technology and demonstrate comparative simulation results that show the feasibility of our approach.","lang":"eng"}],"type":"journal_article","publication":"Elsevier Computer Networks"},{"language":[{"iso":"eng"}],"_id":"54950","user_id":"1112","department":[{"_id":"35"},{"_id":"22"}],"abstract":[{"text":"The mechanisms by which proteases activate the epithelial sodium channel (ENaC) are not yet fully understood. We investigated the effect of extracellular proteases on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of trypsin increased ENaC whole-oocyte currents by about 8-fold without a concomitant increase in channel surface expression. The stimulatory effect of trypsin was preserved in oocytes expressing alphagamma-ENaC, but was abolished in oocytes expressing alphabeta-ENaC. Thus, the gamma-subunit appears to be essential for channel activation by extracellular proteases. Site-directed mutagenesis of a putative prostasin cleavage site in the extracellular loop of the gamma-subunit revealed that mutating the 181Lys residue to alanine (gammaK181A) increases ENaC baseline whole-oocyte currents, decreases channel surface expression, and largely reduces the stimulatory effect of extracellular proteases (trypsin, chymotrypsin and human neutrophil elastase). In single-channel recordings from outside-out patches we demonstrated that the gammaK181A mutation essentially abolishes the activation of near-silent channels by trypsin, while a stimulatory effect of trypsin on channel gating is preserved. This apparent dual effect of trypsin on channel gating and on the recruitment of near-silent channels was confirmed by experiments using the beta518C mutant ENaC which can be converted to a channel with an open probability of nearly one by exposure to a sulfhydryl reagent. Interestingly, the gammaK181A mutation results in the spontaneous appearance of a 67 kDa fragment of the gamma-subunit in the plasma membrane which can be prevented by a furin inhibitor and also occurs after channel activation by extracellular trypsin. This suggests that the mutation promotes channel cleavage and activation by endogenous proteases. This would lower the pool of near-silent channels and explain the constitutive activation and reduced responsiveness of the mutant channel to extracellular proteases. We conclude that the mutated site (K181A) affects a region in the gamma-subunit of ENaC that is functionally important for the activation of near-silent channels by extracellular proteases.","lang":"eng"}],"status":"public","type":"journal_article","publication":"The Journal of Physiology","title":"Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels","doi":"10.1113/jphysiol.2008.154435","date_updated":"2024-07-11T05:13:55Z","publisher":"Wiley","author":[{"full_name":"Diakov, Alexei","last_name":"Diakov","first_name":"Alexei"},{"last_name":"Bera","full_name":"Bera, Katarzyna","first_name":"Katarzyna"},{"first_name":"Marianna","full_name":"Mokrushina, Marianna","last_name":"Mokrushina"},{"last_name":"Krueger","orcid":"0000-0001-5351-1785","full_name":"Krueger, Bettina","id":"49428","first_name":"Bettina"},{"full_name":"Korbmacher, Christoph","last_name":"Korbmacher","first_name":"Christoph"}],"date_created":"2024-06-30T14:02:04Z","volume":586,"year":"2008","citation":{"apa":"Diakov, A., Bera, K., Mokrushina, M., Krueger, B., &#38; Korbmacher, C. (2008). Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. <i>The Journal of Physiology</i>, <i>586</i>(19), 4587–4608. <a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">https://doi.org/10.1113/jphysiol.2008.154435</a>","mla":"Diakov, Alexei, et al. “Cleavage in the γ-Subunit of the Epithelial Sodium Channel (ENaC) Plays an Important Role in the Proteolytic Activation of near-Silent Channels.” <i>The Journal of Physiology</i>, vol. 586, no. 19, Wiley, 2008, pp. 4587–4608, doi:<a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>.","bibtex":"@article{Diakov_Bera_Mokrushina_Krueger_Korbmacher_2008, title={Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels}, volume={586}, DOI={<a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>}, number={19}, journal={The Journal of Physiology}, publisher={Wiley}, author={Diakov, Alexei and Bera, Katarzyna and Mokrushina, Marianna and Krueger, Bettina and Korbmacher, Christoph}, year={2008}, pages={4587–4608} }","short":"A. Diakov, K. Bera, M. Mokrushina, B. Krueger, C. Korbmacher, The Journal of Physiology 586 (2008) 4587–4608.","chicago":"Diakov, Alexei, Katarzyna Bera, Marianna Mokrushina, Bettina Krueger, and Christoph Korbmacher. “Cleavage in the γ-Subunit of the Epithelial Sodium Channel (ENaC) Plays an Important Role in the Proteolytic Activation of near-Silent Channels.” <i>The Journal of Physiology</i> 586, no. 19 (2008): 4587–4608. <a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">https://doi.org/10.1113/jphysiol.2008.154435</a>.","ieee":"A. Diakov, K. Bera, M. Mokrushina, B. Krueger, and C. Korbmacher, “Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels,” <i>The Journal of Physiology</i>, vol. 586, no. 19, pp. 4587–4608, 2008, doi: <a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>.","ama":"Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C. Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. <i>The Journal of Physiology</i>. 2008;586(19):4587–4608. doi:<a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>"},"intvolume":"       586","page":"4587–4608","issue":"19"},{"language":[{"iso":"eng"}],"_id":"54935","user_id":"49428","department":[{"_id":"35"},{"_id":"22"}],"abstract":[{"lang":"eng","text":"Expression of connective tissue growth factor (CTGF) in endothelial cells is modulated by shear stress affecting the organization of the cytoskeleton. The molecular connection between alterations of actin and CTGF expression was investigated in human umbilical vein endothelial cells (HUVEC) and a microvascular endothelial cell line. Overexpression of nonpolymerizable monomeric actin R62D interfered with stress fiber formation in HUVEC and concomitantly reduced immunoreactive CTGF. In microvascular endothelial cells, flow-dependent upregulation of CTGF was prevented by this actin mutant. In contrast, overexpression of actin S14C strengthened filamentous actin and increased CTGF expression. These data indicated an inverse relationship between CTGF expression and monomeric actin. Coexpression of the mutant actins and different CTGF promoter constructs revealed an actin-sensitive site between 3 and 4.5 kb of the CTGF promoter. A CArG-like box at -3791 bp was responsible for actin-dependent CTGF induction as shown by mutagenesis. Overexpression of actin S14C activated the nonmutated promoter significantly more strongly than the mutated promoter. Actin polymerization is regulated by the small GTPase RhoA and activation of serum response factor (SRF). Overexpression of constitutively active RhoA or SRF significantly increased CTGF protein synthesis. The 4.5-kb promoter construct, but not the construct with a mutation in the CArG box, was activated by SRF or RhoA, providing evidence for a functional role of this site in CTGF induction. These findings provide novel evidence that monomeric actin is the connecting link between alterations in the cytoskeleton and CTGF gene expression and demonstrate the importance of SRF in regulating CTGF transcription."}],"status":"public","type":"journal_article","publication":"American Journal of Physiology-Cell Physiology","title":"Actin-dependent regulation of connective tissue growth factor","doi":"10.1152/ajpcell.00552.2006","date_updated":"2024-06-30T13:50:05Z","publisher":"American Physiological Society","date_created":"2024-06-30T13:49:55Z","author":[{"last_name":"Muehlich","full_name":"Muehlich, Susanne","first_name":"Susanne"},{"last_name":"Cicha","full_name":"Cicha, Iwona","first_name":"Iwona"},{"first_name":"Christoph D.","full_name":"Garlichs, Christoph D.","last_name":"Garlichs"},{"first_name":"Bettina","id":"49428","full_name":"Krueger, Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger"},{"first_name":"Guido","last_name":"Posern","full_name":"Posern, Guido"},{"last_name":"Goppelt-Struebe","full_name":"Goppelt-Struebe, Margarete","first_name":"Margarete"}],"volume":292,"year":"2007","citation":{"ieee":"S. Muehlich, I. Cicha, C. D. Garlichs, B. Krueger, G. Posern, and M. Goppelt-Struebe, “Actin-dependent regulation of connective tissue growth factor,” <i>American Journal of Physiology-Cell Physiology</i>, vol. 292, no. 5, pp. C1732–C1738, 2007, doi: <a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>.","chicago":"Muehlich, Susanne, Iwona Cicha, Christoph D. Garlichs, Bettina Krueger, Guido Posern, and Margarete Goppelt-Struebe. “Actin-Dependent Regulation of Connective Tissue Growth Factor.” <i>American Journal of Physiology-Cell Physiology</i> 292, no. 5 (2007): C1732–C1738. <a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">https://doi.org/10.1152/ajpcell.00552.2006</a>.","ama":"Muehlich S, Cicha I, Garlichs CD, Krueger B, Posern G, Goppelt-Struebe M. Actin-dependent regulation of connective tissue growth factor. <i>American Journal of Physiology-Cell Physiology</i>. 2007;292(5):C1732–C1738. doi:<a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>","bibtex":"@article{Muehlich_Cicha_Garlichs_Krueger_Posern_Goppelt-Struebe_2007, title={Actin-dependent regulation of connective tissue growth factor}, volume={292}, DOI={<a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>}, number={5}, journal={American Journal of Physiology-Cell Physiology}, publisher={American Physiological Society}, author={Muehlich, Susanne and Cicha, Iwona and Garlichs, Christoph D. and Krueger, Bettina and Posern, Guido and Goppelt-Struebe, Margarete}, year={2007}, pages={C1732–C1738} }","short":"S. Muehlich, I. Cicha, C.D. Garlichs, B. Krueger, G. Posern, M. Goppelt-Struebe, American Journal of Physiology-Cell Physiology 292 (2007) C1732–C1738.","mla":"Muehlich, Susanne, et al. “Actin-Dependent Regulation of Connective Tissue Growth Factor.” <i>American Journal of Physiology-Cell Physiology</i>, vol. 292, no. 5, American Physiological Society, 2007, pp. C1732–C1738, doi:<a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>.","apa":"Muehlich, S., Cicha, I., Garlichs, C. D., Krueger, B., Posern, G., &#38; Goppelt-Struebe, M. (2007). Actin-dependent regulation of connective tissue growth factor. <i>American Journal of Physiology-Cell Physiology</i>, <i>292</i>(5), C1732–C1738. <a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">https://doi.org/10.1152/ajpcell.00552.2006</a>"},"page":"C1732–C1738","intvolume":"       292","issue":"5"},{"publication":"1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)","type":"conference","abstract":[{"lang":"eng","text":"The investigation and the development of self-organizing systems are especially needed for operation and control in massively distributed systems such as Sensor and Actor Networks (SANETs). The main issues addressed by self-organization techniques are scalability, network lifetime, and real-time support. In the literature, biological principles are often cited as inspirations for technical solutions, especially in the domain of self-organization. This concept already resulted in a good number of solutions with significant impact such as ant-based routing and immune system inspired network security solutions. In this paper, another specific biological field is investigated: cellular signaling cascades for event-specific reaction initiated by individual cells in collaboration with their direct neighbors. Information between cells are transmitted via proteins and result in the cascade of protein–protein or protein–DNA interactions to produce a specific cellular answer, e.g. the activation of cells or the transmission of mediators. These processes are programmed in every individual cell and lead to a coordinated reaction on a higher organization platform. We transferred these mechanisms to operation and control in SANETs. In particular, a rule-based processing scheme relying on the main concepts of cellular signaling cascades has been developed. It is relying on simple local rules and providing problem specific reaction such as local actuation control and data manipulation. We describe this Rule-based Sensor Network (RSN) technology and demonstrate comparative simulation results that show the feasibility of our approach."}],"status":"public","_id":"54946","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","language":[{"iso":"eng"}],"place":"Rome, Italy","year":"2007","citation":{"chicago":"Dressler, Falko, Isabel Dietrich, Reinhard German, and Bettina Krueger. “Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades.” In <i>1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)</i>. Rome, Italy: Association for Computing Machinery (ACM), 2007. <a href=\"https://doi.org/10.1145/1365562.1365572\">https://doi.org/10.1145/1365562.1365572</a>.","ieee":"F. Dressler, I. Dietrich, R. German, and B. Krueger, “Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades,” 2007, doi: <a href=\"https://doi.org/10.1145/1365562.1365572\">10.1145/1365562.1365572</a>.","ama":"Dressler F, Dietrich I, German R, Krueger B. Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades. In: <i>1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)</i>. Association for Computing Machinery (ACM); 2007. doi:<a href=\"https://doi.org/10.1145/1365562.1365572\">10.1145/1365562.1365572</a>","bibtex":"@inproceedings{Dressler_Dietrich_German_Krueger_2007, place={Rome, Italy}, title={Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades}, DOI={<a href=\"https://doi.org/10.1145/1365562.1365572\">10.1145/1365562.1365572</a>}, booktitle={1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)}, publisher={Association for Computing Machinery (ACM)}, author={Dressler, Falko and Dietrich, Isabel and German, Reinhard and Krueger, Bettina}, year={2007} }","short":"F. Dressler, I. Dietrich, R. German, B. Krueger, in: 1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007), Association for Computing Machinery (ACM), Rome, Italy, 2007.","mla":"Dressler, Falko, et al. “Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades.” <i>1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)</i>, Association for Computing Machinery (ACM), 2007, doi:<a href=\"https://doi.org/10.1145/1365562.1365572\">10.1145/1365562.1365572</a>.","apa":"Dressler, F., Dietrich, I., German, R., &#38; Krueger, B. (2007). Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades. <i>1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)</i>. <a href=\"https://doi.org/10.1145/1365562.1365572\">https://doi.org/10.1145/1365562.1365572</a>"},"publisher":"Association for Computing Machinery (ACM)","date_updated":"2024-06-30T13:59:29Z","author":[{"last_name":"Dressler","full_name":"Dressler, Falko","first_name":"Falko"},{"first_name":"Isabel","full_name":"Dietrich, Isabel","last_name":"Dietrich"},{"last_name":"German","full_name":"German, Reinhard","first_name":"Reinhard"},{"full_name":"Krueger, Bettina","id":"49428","last_name":"Krueger","orcid":"0000-0001-5351-1785","first_name":"Bettina"}],"date_created":"2024-06-30T13:59:18Z","title":"Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades","doi":"10.1145/1365562.1365572"},{"language":[{"iso":"eng"}],"department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","_id":"54947","status":"public","abstract":[{"lang":"eng","text":"In Wireless Sensor Networks (WSNs), address-based routing approaches often lead to severe problems due to node mobility, energy-saving sleep-cycles, and often missing or unreliable address information. Data-centric routing schemes such as flooding or gossiping solve these problems but may lead to congestion or starvation. Based on biologically inspired mechanisms known from cellular signaling pathways, we discovered potentials in enhancing the communication required for self-organization in network environments suffering from data paths with low reliability and time variations of the reliability. Using an importance factor for particular transmissions in combination with feedback loops, the overall quality of the global system can be increased. The resulting algorithm, Weighted Probabilistic Data Dissemination (WPDD), includes an inherent adaptation to changing network conditions. Congestion control is supported as well as prioritized data communication. This paper outlines the working behavior of WPDD and demonstrates its applicability based on selected simulation results."}],"publication":"IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)","type":"conference","doi":"10.1109/FBIT.2007.23","title":"Adaptive Data Dissemination in Sensor Networks using WPDD","date_created":"2024-06-30T13:59:56Z","author":[{"first_name":"Falko","last_name":"Dressler","full_name":"Dressler, Falko"},{"last_name":"German","full_name":"German, Reinhard","first_name":"Reinhard"},{"first_name":"Bettina","id":"49428","full_name":"Krueger, Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger"}],"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","date_updated":"2024-06-30T14:00:05Z","page":"827–832","citation":{"chicago":"Dressler, Falko, Reinhard German, and Bettina Krueger. “Adaptive Data Dissemination in Sensor Networks Using WPDD.” In <i>IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)</i>, 827–832. Jeju City, South Korea: Institute of Electrical and Electronics Engineers (IEEE), 2007. <a href=\"https://doi.org/10.1109/FBIT.2007.23\">https://doi.org/10.1109/FBIT.2007.23</a>.","ieee":"F. Dressler, R. German, and B. Krueger, “Adaptive Data Dissemination in Sensor Networks using WPDD,” in <i>IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)</i>, 2007, pp. 827–832, doi: <a href=\"https://doi.org/10.1109/FBIT.2007.23\">10.1109/FBIT.2007.23</a>.","ama":"Dressler F, German R, Krueger B. Adaptive Data Dissemination in Sensor Networks using WPDD. In: <i>IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)</i>. Institute of Electrical and Electronics Engineers (IEEE); 2007:827–832. doi:<a href=\"https://doi.org/10.1109/FBIT.2007.23\">10.1109/FBIT.2007.23</a>","apa":"Dressler, F., German, R., &#38; Krueger, B. (2007). Adaptive Data Dissemination in Sensor Networks using WPDD. <i>IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)</i>, 827–832. <a href=\"https://doi.org/10.1109/FBIT.2007.23\">https://doi.org/10.1109/FBIT.2007.23</a>","mla":"Dressler, Falko, et al. “Adaptive Data Dissemination in Sensor Networks Using WPDD.” <i>IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)</i>, Institute of Electrical and Electronics Engineers (IEEE), 2007, pp. 827–832, doi:<a href=\"https://doi.org/10.1109/FBIT.2007.23\">10.1109/FBIT.2007.23</a>.","bibtex":"@inproceedings{Dressler_German_Krueger_2007, place={Jeju City, South Korea}, title={Adaptive Data Dissemination in Sensor Networks using WPDD}, DOI={<a href=\"https://doi.org/10.1109/FBIT.2007.23\">10.1109/FBIT.2007.23</a>}, booktitle={IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)}, publisher={Institute of Electrical and Electronics Engineers (IEEE)}, author={Dressler, Falko and German, Reinhard and Krueger, Bettina}, year={2007}, pages={827–832} }","short":"F. Dressler, R. German, B. Krueger, in: IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007), Institute of Electrical and Electronics Engineers (IEEE), Jeju City, South Korea, 2007, pp. 827–832."},"year":"2007","place":"Jeju City, South Korea"},{"title":"VEGF induces proliferation, migration, and TGF-$\\beta$1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase","doi":"10.1016/j.bbrc.2005.07.005","date_updated":"2024-06-30T13:50:44Z","publisher":"Elsevier","volume":334,"date_created":"2024-06-30T13:50:32Z","author":[{"first_name":"Zhao-Dong","full_name":"Li, Zhao-Dong","last_name":"Li"},{"last_name":"Bork","full_name":"Bork, Jens Peter","first_name":"Jens Peter"},{"full_name":"Krueger, Bettina","id":"49428","orcid":"0000-0001-5351-1785","last_name":"Krueger","first_name":"Bettina"},{"first_name":"Eleonora","last_name":"Patsenker","full_name":"Patsenker, Eleonora"},{"last_name":"Schulze-Krebs","full_name":"Schulze-Krebs, Anja","first_name":"Anja"},{"first_name":"Eckhart G.","full_name":"Hahn, Eckhart G.","last_name":"Hahn"},{"last_name":"Schuppan","full_name":"Schuppan, Detlef","first_name":"Detlef"}],"year":"2005","page":"1049–1060","intvolume":"       334","citation":{"bibtex":"@article{Li_Bork_Krueger_Patsenker_Schulze-Krebs_Hahn_Schuppan_2005, title={VEGF induces proliferation, migration, and TGF-$\\beta$1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase}, volume={334}, DOI={<a href=\"https://doi.org/10.1016/j.bbrc.2005.07.005\">10.1016/j.bbrc.2005.07.005</a>}, number={4}, journal={Biochemical and Biophysical Research Communications}, publisher={Elsevier}, author={Li, Zhao-Dong and Bork, Jens Peter and Krueger, Bettina and Patsenker, Eleonora and Schulze-Krebs, Anja and Hahn, Eckhart G. and Schuppan, Detlef}, year={2005}, pages={1049–1060} }","short":"Z.-D. Li, J.P. Bork, B. Krueger, E. Patsenker, A. Schulze-Krebs, E.G. Hahn, D. Schuppan, Biochemical and Biophysical Research Communications 334 (2005) 1049–1060.","mla":"Li, Zhao-Dong, et al. “VEGF Induces Proliferation, Migration, and TGF-$\\beta$1 Expression in Mouse Glomerular Endothelial Cells via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase.” <i>Biochemical and Biophysical Research Communications</i>, vol. 334, no. 4, Elsevier, 2005, pp. 1049–1060, doi:<a href=\"https://doi.org/10.1016/j.bbrc.2005.07.005\">10.1016/j.bbrc.2005.07.005</a>.","apa":"Li, Z.-D., Bork, J. P., Krueger, B., Patsenker, E., Schulze-Krebs, A., Hahn, E. G., &#38; Schuppan, D. (2005). VEGF induces proliferation, migration, and TGF-$\\beta$1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase. <i>Biochemical and Biophysical Research Communications</i>, <i>334</i>(4), 1049–1060. <a href=\"https://doi.org/10.1016/j.bbrc.2005.07.005\">https://doi.org/10.1016/j.bbrc.2005.07.005</a>","chicago":"Li, Zhao-Dong, Jens Peter Bork, Bettina Krueger, Eleonora Patsenker, Anja Schulze-Krebs, Eckhart G. Hahn, and Detlef Schuppan. “VEGF Induces Proliferation, Migration, and TGF-$\\beta$1 Expression in Mouse Glomerular Endothelial Cells via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase.” <i>Biochemical and Biophysical Research Communications</i> 334, no. 4 (2005): 1049–1060. <a href=\"https://doi.org/10.1016/j.bbrc.2005.07.005\">https://doi.org/10.1016/j.bbrc.2005.07.005</a>.","ieee":"Z.-D. Li <i>et al.</i>, “VEGF induces proliferation, migration, and TGF-$\\beta$1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase,” <i>Biochemical and Biophysical Research Communications</i>, vol. 334, no. 4, pp. 1049–1060, 2005, doi: <a href=\"https://doi.org/10.1016/j.bbrc.2005.07.005\">10.1016/j.bbrc.2005.07.005</a>.","ama":"Li Z-D, Bork JP, Krueger B, et al. VEGF induces proliferation, migration, and TGF-$\\beta$1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase. <i>Biochemical and Biophysical Research Communications</i>. 2005;334(4):1049–1060. doi:<a href=\"https://doi.org/10.1016/j.bbrc.2005.07.005\">10.1016/j.bbrc.2005.07.005</a>"},"issue":"4","language":[{"iso":"eng"}],"_id":"54936","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","abstract":[{"lang":"eng","text":"The role of glomerular endothelial cells in kidney fibrosis remains incompletely understood. While endothelia are indispensable for repair of acute damage, they can produce extracellular matrix proteins and profibrogenic cytokines that promote fibrogenesis. We used a murine cell line with all features of glomerular endothelial cells (glEND.2), which dissected the effects of vascular endothelial growth factor (VEGF) on cell migration, proliferation, and profibrogenic cytokine production. VEGF dose-dependently induced glEND.2 cell migration and proliferation, accompanied by up-regulation of VEGFR-2 phosphorylation and mRNA expression. VEGF induced a profibrogenic gene expression profile, including up-regulation of TGF-beta1 mRNA, enhanced TGF-beta1 secretion, and bioactivity. VEGF-induced endothelial cell migration and TGF-beta1 induction were mediated by the phosphatidyl-inositol-3 kinase pathway, while proliferation was dependent on the Erk1/2 MAP kinase pathway. This suggests that differential modulation of glomerular angiogenesis by selective inhibition of the two identified VEGF-induced signaling pathways could be a therapeutic approach to treat kidney fibrosis."}],"status":"public","publication":"Biochemical and Biophysical Research Communications","type":"journal_article"},{"year":"2005","intvolume":"         1","page":"43–50","citation":{"bibtex":"@article{Krueger_Dressler_2005, title={Molecular Processes as a Basis for Autonomous Networking}, volume={1}, number={1}, journal={IPSI Transactions on Advances Research: Issues in Computer Science and Engineering}, publisher={IPSI}, author={Krueger, Bettina and Dressler, Falko}, year={2005}, pages={43–50} }","short":"B. Krueger, F. Dressler, IPSI Transactions on Advances Research: Issues in Computer Science and Engineering 1 (2005) 43–50.","mla":"Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis for Autonomous Networking.” <i>IPSI Transactions on Advances Research: Issues in Computer Science and Engineering</i>, vol. 1, no. 1, IPSI, 2005, pp. 43–50.","apa":"Krueger, B., &#38; Dressler, F. (2005). Molecular Processes as a Basis for Autonomous Networking. <i>IPSI Transactions on Advances Research: Issues in Computer Science and Engineering</i>, <i>1</i>(1), 43–50.","ama":"Krueger B, Dressler F. Molecular Processes as a Basis for Autonomous Networking. <i>IPSI Transactions on Advances Research: Issues in Computer Science and Engineering</i>. 2005;1(1):43–50.","chicago":"Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis for Autonomous Networking.” <i>IPSI Transactions on Advances Research: Issues in Computer Science and Engineering</i> 1, no. 1 (2005): 43–50.","ieee":"B. Krueger and F. Dressler, “Molecular Processes as a Basis for Autonomous Networking,” <i>IPSI Transactions on Advances Research: Issues in Computer Science and Engineering</i>, vol. 1, no. 1, pp. 43–50, 2005."},"issue":"1","title":"Molecular Processes as a Basis for Autonomous Networking","publisher":"IPSI","date_updated":"2024-06-30T13:56:35Z","volume":1,"date_created":"2024-06-30T13:56:26Z","author":[{"first_name":"Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger","id":"49428","full_name":"Krueger, Bettina"},{"first_name":"Falko","full_name":"Dressler, Falko","last_name":"Dressler"}],"abstract":[{"lang":"eng","text":"Autonomous networking has become the buzzword for attempts of building high-scalable network architectures, which are self-organizing, self-maintaining and self-healing. Few of these approaches were successful and none has shown to provide all the promised functions. We try to study the processes in computer networks using molecular processes as the paradigm. This novel approach shows many similarities between computer networking and cellular mechanisms. In this paper, we focus on the area of network security as one research area with high demand for high-scalable mechanisms providing the needed functionality. After identifying similarities between nature and technology, we discuss potential research domains, which are high potentials for learning directly from molecular biology using the example of security threats in communication networks. We see the proposed mechanism as a generic approach for autonomous networking. The countermeasures against attacks in computer networks are only a special example to introduce the mechanisms."}],"status":"public","publication":"IPSI Transactions on Advances Research: Issues in Computer Science and Engineering","type":"journal_article","language":[{"iso":"eng"}],"_id":"54941","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428"},{"date_updated":"2024-06-30T14:01:23Z","publisher":"Springer","date_created":"2024-06-30T14:01:12Z","author":[{"full_name":"Dressler, Falko","last_name":"Dressler","first_name":"Falko"},{"id":"49428","full_name":"Krueger, Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger","first_name":"Bettina"},{"first_name":"Gerhard","full_name":"Fuchs, Gerhard","last_name":"Fuchs"},{"full_name":"German, Reinhard","last_name":"German","first_name":"Reinhard"}],"title":"Self-Organization in Sensor Networks using Bio-Inspired Mechanisms","place":"Innsbruck, Austria","year":"2005","page":"139–144","citation":{"mla":"Dressler, Falko, et al. “Self-Organization in Sensor Networks Using Bio-Inspired Mechanisms.” <i>18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence</i>, Springer, 2005, pp. 139–144.","short":"F. Dressler, B. Krueger, G. Fuchs, R. German, in: 18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence, Springer, Innsbruck, Austria, 2005, pp. 139–144.","bibtex":"@inproceedings{Dressler_Krueger_Fuchs_German_2005, place={Innsbruck, Austria}, title={Self-Organization in Sensor Networks using Bio-Inspired Mechanisms}, booktitle={18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence}, publisher={Springer}, author={Dressler, Falko and Krueger, Bettina and Fuchs, Gerhard and German, Reinhard}, year={2005}, pages={139–144} }","apa":"Dressler, F., Krueger, B., Fuchs, G., &#38; German, R. (2005). Self-Organization in Sensor Networks using Bio-Inspired Mechanisms. <i>18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence</i>, 139–144.","chicago":"Dressler, Falko, Bettina Krueger, Gerhard Fuchs, and Reinhard German. “Self-Organization in Sensor Networks Using Bio-Inspired Mechanisms.” In <i>18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence</i>, 139–144. Innsbruck, Austria: Springer, 2005.","ieee":"F. Dressler, B. Krueger, G. Fuchs, and R. German, “Self-Organization in Sensor Networks using Bio-Inspired Mechanisms,” in <i>18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence</i>, 2005, pp. 139–144.","ama":"Dressler F, Krueger B, Fuchs G, German R. Self-Organization in Sensor Networks using Bio-Inspired Mechanisms. In: <i>18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence</i>. Springer; 2005:139–144."},"_id":"54948","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","language":[{"iso":"eng"}],"publication":"18th ACM/GI/ITG International Conference on Architecture of Computing Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence","type":"conference","abstract":[{"text":"Bio-inspired communication methodologies promise to enable more scalable self-organizing network infrastructures. Especially in the area of mobile ad hoc sensor networks, such solutions are required in order to qualify them for simplified development and deployment based on autonomously evolving mechanisms to work on global tasks, i.e. to show an emergent behavior. In this paper, we introduce the ongoing research of our Autonomic Networking group focused on the developments on efficient data dissemination in sensor networks. A particular example of how to study biological processes and to adapt the results in communication networks, the feedback loop mechanism, depicts the potentials of this research area.","lang":"eng"}],"status":"public"},{"year":"2004","place":"Bielefeld, Germany","citation":{"apa":"Dressler, F., &#38; Krueger, B. (2004). Cell biology as a key to computer networking. <i>German Conference on Bioinformatics 2004 (GCB 2004), Poster Session</i>.","mla":"Dressler, Falko, and Bettina Krueger. “Cell Biology as a Key to Computer Networking.” <i>German Conference on Bioinformatics 2004 (GCB 2004), Poster Session</i>, 2004.","short":"F. Dressler, B. Krueger, in: German Conference on Bioinformatics 2004 (GCB 2004), Poster Session, Bielefeld, Germany, 2004.","bibtex":"@inproceedings{Dressler_Krueger_2004, place={Bielefeld, Germany}, title={Cell biology as a key to computer networking}, booktitle={German Conference on Bioinformatics 2004 (GCB 2004), Poster Session}, author={Dressler, Falko and Krueger, Bettina}, year={2004} }","chicago":"Dressler, Falko, and Bettina Krueger. “Cell Biology as a Key to Computer Networking.” In <i>German Conference on Bioinformatics 2004 (GCB 2004), Poster Session</i>. Bielefeld, Germany, 2004.","ieee":"F. Dressler and B. Krueger, “Cell biology as a key to computer networking,” 2004.","ama":"Dressler F, Krueger B. Cell biology as a key to computer networking. In: <i>German Conference on Bioinformatics 2004 (GCB 2004), Poster Session</i>. ; 2004."},"title":"Cell biology as a key to computer networking","date_updated":"2024-06-30T13:55:23Z","date_created":"2024-05-10T07:40:39Z","author":[{"full_name":"Dressler, Falko","last_name":"Dressler","first_name":"Falko"},{"full_name":"Krueger, Bettina","id":"49428","orcid":"0000-0001-5351-1785","last_name":"Krueger","first_name":"Bettina"}],"abstract":[{"lang":"eng","text":"Besides to classical research area of bioinformatics, the turn to nature for solutions to technological questions has brought us many unforeseen great concepts. This encouraging course seems to hold on for many aspects in technology. Many efforts were made in the area of computer technology employing mechanisms known from biological systems. The most known examples are evolutionary algorithms and the artificial immune system. One application is in network security, e.g. for the search for viruses and worms, where the immune system was used as an inspiration.In contrast, the focus of our group lays on trying to map the cellular and molecular biology to networking architectures. Recently, it was shown that the known approaches to study effects in computer networking, especially methods to analyze the behavior of large scale networks suffer from many presumptions. We try to study this behavior by analyzing the internal functioning of network components as well as there interactions in comparison with cellular systems and the associated intra and extra cellular signaling pathways.The main focus of this work is to show the similarities of computer networks and cellular systems. Based on the knowledge about cellular metabolism, new concepts for the behavior patterns of routers, monitor systems, and firewalls can be deduced and the efficiency of individual sub-systems can be increased. Focusing on examples of hot topics in the computer society, i.e. network security, potential solutions motivated by cellular behavior are currently studied and, hopefully, will soon bring new results in these areas.Independently from these examinations, we try to show the power of our novel approach by introducing the basic mechanisms and interactions as well as a self-evident application. Doing this, we must keep in mind that the deeper the parallels between biology and technology, the more important it is to map the corresponding elements correctly."}],"status":"public","publication":"German Conference on Bioinformatics 2004 (GCB 2004), Poster Session","type":"conference","language":[{"iso":"eng"}],"_id":"54143","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428"},{"_id":"54940","user_id":"49428","department":[{"_id":"35"},{"_id":"22"}],"language":[{"iso":"eng"}],"type":"conference","publication":"International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004)","abstract":[{"text":"Autonomous networking has become the buzzword for attempts of building high-scalable network architectures, which are self-organizing, self-maintaining and self-healing. Few of these approaches were successful and none has shown to provide all the promised functions. We try to study the processes in computer networks using molecular processes as the paradigm. This novel approach shows many similarities between computer networking and cellular mechanisms. In this paper, we focus on the area of network security as one research area with high demand for high-scalable mechanisms providing the needed functionality. After identifying similarities between nature and technology, we discuss potential research domains, which are high potentials for learning directly from biology at the example of security attacks in networks. We see the proposed mechanism as a generic approach for autonomous networking. The countermeasures against attacks in computer networks are only a special example to introduce the mechanisms.","lang":"eng"}],"status":"public","date_updated":"2024-06-30T13:56:07Z","author":[{"last_name":"Krueger","orcid":"0000-0001-5351-1785","full_name":"Krueger, Bettina","id":"49428","first_name":"Bettina"},{"last_name":"Dressler","full_name":"Dressler, Falko","first_name":"Falko"}],"date_created":"2024-06-30T13:55:57Z","title":"Molecular Processes as a Basis for Autonomous Networking","year":"2004","place":"Stockholm, Sweden","citation":{"apa":"Krueger, B., &#38; Dressler, F. (2004). Molecular Processes as a Basis for Autonomous Networking. <i>International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004)</i>.","mla":"Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis for Autonomous Networking.” <i>International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004)</i>, 2004.","short":"B. Krueger, F. Dressler, in: International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004), Stockholm, Sweden, 2004.","bibtex":"@inproceedings{Krueger_Dressler_2004, place={Stockholm, Sweden}, title={Molecular Processes as a Basis for Autonomous Networking}, booktitle={International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004)}, author={Krueger, Bettina and Dressler, Falko}, year={2004} }","ieee":"B. Krueger and F. Dressler, “Molecular Processes as a Basis for Autonomous Networking,” 2004.","chicago":"Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis for Autonomous Networking.” In <i>International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004)</i>. Stockholm, Sweden, 2004.","ama":"Krueger B, Dressler F. Molecular Processes as a Basis for Autonomous Networking. In: <i>International IPSI Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary Research (IPSI 2004)</i>. ; 2004."}}]