---
_id: '54944'
abstract:
- lang: eng
text: The epithelial sodium channel (ENaC) is probably a heterotrimer with three
well characterized subunits (alphabetagamma). In humans an additional delta-subunit
(delta-hENaC) exists but little is known about its function. Using the Xenopus
laevis oocyte expression system, we compared the functional properties of alphabetagamma-
and deltabetagamma-hENaC and investigated whether deltabetagamma-hENaC can be
proteolytically activated. The amiloride-sensitive ENaC whole-cell current (DeltaI(ami))
was about 11-fold larger in oocytes expressing deltabetagamma-hENaC than in oocytes
expressing alphabetagamma-hENaC. The 2-fold larger single-channel Na(+) conductance
of deltabetagamma-hENaC cannot explain this difference. Using a chemiluminescence
assay, we demonstrated that an increased channel surface expression is also not
the cause. Thus, overall channel activity of deltabetagamma-hENaC must be higher
than that of alphabetagamma-hENaC. Experiments exploiting the properties of the
known betaS520C mutant ENaC confirmed this conclusion. Moreover, chymotrypsin
had a reduced stimulatory effect on deltabetagamma-hENaC whole-cell currents compared
with its effect on alphabetagamma-hENaC whole-cell currents (2-fold versus 5-fold).
This suggests that the cell surface pool of so-called near-silent channels that
can be proteolytically activated is smaller for deltabetagamma-hENaC than for
alphabetagamma-hENaC. Proteolytic activation of deltabetagamma-hENaC was associated
with the appearance of a delta-hENaC cleavage product at the cell surface. Finally,
we demonstrated that a short inhibitory 13-mer peptide corresponding to a region
of the extracellular loop of human alpha-ENaC inhibited DeltaI(ami) in oocytes
expressing alphabetagamma-hENaC but not in those expressing deltabetagamma-hENaC.
We conclude that the delta-subunit of ENaC alters proteolytic channel activation
and enhances base-line channel activity.
author:
- first_name: Silke
full_name: Haerteis, Silke
last_name: Haerteis
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Christoph
full_name: Korbmacher, Christoph
last_name: Korbmacher
- first_name: Robert
full_name: Rauh, Robert
last_name: Rauh
citation:
ama: Haerteis S, Krueger B, Korbmacher C, Rauh R. The $\delta$-Subunit of the Epithelial
Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation.
Journal of Biological Chemistry. 2009;284(42):29024–29040. doi:10.1074/jbc.m109.018945
apa: Haerteis, S., Krueger, B., Korbmacher, C., & Rauh, R. (2009). The $\delta$-Subunit
of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic
ENaC Activation. Journal of Biological Chemistry, 284(42), 29024–29040.
https://doi.org/10.1074/jbc.m109.018945
bibtex: '@article{Haerteis_Krueger_Korbmacher_Rauh_2009, title={The $\delta$-Subunit
of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic
ENaC Activation}, volume={284}, DOI={10.1074/jbc.m109.018945},
number={42}, journal={Journal of Biological Chemistry}, publisher={American Society
for Biochemistry and Molecular Biology}, author={Haerteis, Silke and Krueger,
Bettina and Korbmacher, Christoph and Rauh, Robert}, year={2009}, pages={29024–29040}
}'
chicago: 'Haerteis, Silke, Bettina Krueger, Christoph Korbmacher, and Robert Rauh.
“The $\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel
Activity and Alters Proteolytic ENaC Activation.” Journal of Biological Chemistry
284, no. 42 (2009): 29024–29040. https://doi.org/10.1074/jbc.m109.018945.'
ieee: 'S. Haerteis, B. Krueger, C. Korbmacher, and R. Rauh, “The $\delta$-Subunit
of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic
ENaC Activation,” Journal of Biological Chemistry, vol. 284, no. 42, pp.
29024–29040, 2009, doi: 10.1074/jbc.m109.018945.'
mla: Haerteis, Silke, et al. “The $\delta$-Subunit of the Epithelial Sodium Channel
(ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation.” Journal
of Biological Chemistry, vol. 284, no. 42, American Society for Biochemistry
and Molecular Biology, 2009, pp. 29024–29040, doi:10.1074/jbc.m109.018945.
short: S. Haerteis, B. Krueger, C. Korbmacher, R. Rauh, Journal of Biological Chemistry
284 (2009) 29024–29040.
date_created: 2024-06-30T13:58:07Z
date_updated: 2024-06-30T13:58:15Z
department:
- _id: '35'
- _id: '22'
doi: 10.1074/jbc.m109.018945
intvolume: ' 284'
issue: '42'
language:
- iso: eng
page: 29024–29040
publication: Journal of Biological Chemistry
publisher: American Society for Biochemistry and Molecular Biology
status: public
title: The $\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel
Activity and Alters Proteolytic ENaC Activation
type: journal_article
user_id: '49428'
volume: 284
year: '2009'
...
---
_id: '54938'
abstract:
- lang: eng
text: The lipid environment of the epithelial sodium channel (ENaC) and its possible
association with so-called lipid rafts may be relevant to its function. The aim
of our study was to confirm the association of ENaC with lipid rafts and to analyze
the effect of cholesterol depletion of the plasma membrane by methyl-beta-cyclodextrin
(MbetaCD) on channel function and regulation. Using sucrose density gradient centrifugation
we demonstrated that a significant portion of ENaC protein distributes to low
density fractions thought to be typical lipid raft fractions. Importantly, cholesterol
depletion of cell lysate by MbetaCD shifted ENaC to non-raft fractions of higher
density. Live cell imaging demonstrated that treatment with MbetaCD largely reduced
filipin staining over time, confirming cholesterol depletion of the plasma membrane.
For electrophysiological studies intact oocytes were exposed to 20 mM MbetaCD
for three hours. MbetaCD treatment had no consistent effect on baseline whole-cell
ENaC currents. In addition to the typical single channel conductance of about
5 pS, subconductance states of ENaC were occasionally observed in patches from
MbetaCD treated but not from control oocytes. Importantly, in outside-out patch
clamp recordings the stimulatory effect of recombinant SGK1 in the pipette solution
was essentially abolished in oocytes pretreated with MbetaCD. These results indicate
that ENaC activation by cytosolic SGK1 is compromised by removing cholesterol
from the plasma membrane. Thus, ENaC activation by SGK1 may require the presence
of an intact lipid environment and/or of lipid rafts as signalling platform.
author:
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Silke
full_name: Haerteis, Silke
last_name: Haerteis
- first_name: Limin
full_name: Yang, Limin
last_name: Yang
- first_name: Andrea
full_name: Hartner, Andrea
last_name: Hartner
- first_name: Robert
full_name: Rauh, Robert
last_name: Rauh
- first_name: Christoph
full_name: Korbmacher, Christoph
last_name: Korbmacher
- first_name: Alexei
full_name: Diakov, Alexei
last_name: Diakov
citation:
ama: Krueger B, Haerteis S, Yang L, et al. Cholesterol Depletion of the Plasma Membrane
Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1. Cellular
Physiology and Biochemistry. 2009;24(5-6):605–618. doi:10.1159/000257516
apa: Krueger, B., Haerteis, S., Yang, L., Hartner, A., Rauh, R., Korbmacher, C.,
& Diakov, A. (2009). Cholesterol Depletion of the Plasma Membrane Prevents
Activation of the Epithelial Sodium Channel (ENaC) by SGK1. Cellular Physiology
and Biochemistry, 24(5–6), 605–618. https://doi.org/10.1159/000257516
bibtex: '@article{Krueger_Haerteis_Yang_Hartner_Rauh_Korbmacher_Diakov_2009, title={Cholesterol
Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium
Channel (ENaC) by SGK1}, volume={24}, DOI={10.1159/000257516},
number={5–6}, journal={Cellular Physiology and Biochemistry}, publisher={S. Karger
AG}, author={Krueger, Bettina and Haerteis, Silke and Yang, Limin and Hartner,
Andrea and Rauh, Robert and Korbmacher, Christoph and Diakov, Alexei}, year={2009},
pages={605–618} }'
chicago: 'Krueger, Bettina, Silke Haerteis, Limin Yang, Andrea Hartner, Robert Rauh,
Christoph Korbmacher, and Alexei Diakov. “Cholesterol Depletion of the Plasma
Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1.”
Cellular Physiology and Biochemistry 24, no. 5–6 (2009): 605–618. https://doi.org/10.1159/000257516.'
ieee: 'B. Krueger et al., “Cholesterol Depletion of the Plasma Membrane Prevents
Activation of the Epithelial Sodium Channel (ENaC) by SGK1,” Cellular Physiology
and Biochemistry, vol. 24, no. 5–6, pp. 605–618, 2009, doi: 10.1159/000257516.'
mla: Krueger, Bettina, et al. “Cholesterol Depletion of the Plasma Membrane Prevents
Activation of the Epithelial Sodium Channel (ENaC) by SGK1.” Cellular Physiology
and Biochemistry, vol. 24, no. 5–6, S. Karger AG, 2009, pp. 605–618, doi:10.1159/000257516.
short: B. Krueger, S. Haerteis, L. Yang, A. Hartner, R. Rauh, C. Korbmacher, A.
Diakov, Cellular Physiology and Biochemistry 24 (2009) 605–618.
date_created: 2024-06-30T13:52:19Z
date_updated: 2024-06-30T13:52:27Z
department:
- _id: '35'
- _id: '22'
doi: 10.1159/000257516
intvolume: ' 24'
issue: 5-6
language:
- iso: eng
page: 605–618
publication: Cellular Physiology and Biochemistry
publisher: S. Karger AG
status: public
title: Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial
Sodium Channel (ENaC) by SGK1
type: journal_article
user_id: '49428'
volume: 24
year: '2009'
...
---
_id: '54945'
abstract:
- lang: eng
text: We describe a programming scheme for massively distributed systems that are
assumed to self-organize according to a given set of simple rules. The focus of
this investigation is operation and control in Sensor and Actor Networks (SANETs).
The main issues addressed by self-organization techniques are scalability, network
lifetime, and real-time support. In the literature, biological principles are
often cited as inspirations for technical solutions, especially in the domain
of self-organization. We developed a system named Rule-based Sensor Network (RSN)
according to the observed communication and control behavior in cellular communication.
Cellular signaling cascades allow the event-specific reaction initiated by individual
cells in collaboration with their direct neighbors. Information between cells
are transmitted via proteins and result in the cascade of protein-protein or protein-DNA
interactions to produce a specific cellular answer, e.g. the activation of cells
or the transmission of mediators. These processes are programmed in every individual
cell and lead to a coordinated reaction on a higher organization platform. We
transferred these mechanisms to operation and control in SANETs. In particular,
a rule-based processing scheme relying on the main concepts of cellular signaling
cascades has been developed. It relies on simple local rules and provides problem
specific reaction such as local actuation control and data manipulation. We describe
this RSN technology and demonstrate comparative simulation results that show the
feasibility of our approach.
author:
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
- first_name: Isabel
full_name: Dietrich, Isabel
last_name: Dietrich
- first_name: Reinhard
full_name: German, Reinhard
last_name: German
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
citation:
ama: Dressler F, Dietrich I, German R, Krueger B. A Rule-based System for Programming
Self-Organized Sensor and Actor Networks. Elsevier Computer Networks. 2009;53(10):1737–1750.
doi:10.1016/j.comnet.2008.09.007
apa: Dressler, F., Dietrich, I., German, R., & Krueger, B. (2009). A Rule-based
System for Programming Self-Organized Sensor and Actor Networks. Elsevier Computer
Networks, 53(10), 1737–1750. https://doi.org/10.1016/j.comnet.2008.09.007
bibtex: '@article{Dressler_Dietrich_German_Krueger_2009, title={A Rule-based System
for Programming Self-Organized Sensor and Actor Networks}, volume={53}, DOI={10.1016/j.comnet.2008.09.007},
number={10}, journal={Elsevier Computer Networks}, publisher={Elsevier}, author={Dressler,
Falko and Dietrich, Isabel and German, Reinhard and Krueger, Bettina}, year={2009},
pages={1737–1750} }'
chicago: 'Dressler, Falko, Isabel Dietrich, Reinhard German, and Bettina Krueger.
“A Rule-Based System for Programming Self-Organized Sensor and Actor Networks.”
Elsevier Computer Networks 53, no. 10 (2009): 1737–1750. https://doi.org/10.1016/j.comnet.2008.09.007.'
ieee: 'F. Dressler, I. Dietrich, R. German, and B. Krueger, “A Rule-based System
for Programming Self-Organized Sensor and Actor Networks,” Elsevier Computer
Networks, vol. 53, no. 10, pp. 1737–1750, 2009, doi: 10.1016/j.comnet.2008.09.007.'
mla: Dressler, Falko, et al. “A Rule-Based System for Programming Self-Organized
Sensor and Actor Networks.” Elsevier Computer Networks, vol. 53, no. 10,
Elsevier, 2009, pp. 1737–1750, doi:10.1016/j.comnet.2008.09.007.
short: F. Dressler, I. Dietrich, R. German, B. Krueger, Elsevier Computer Networks
53 (2009) 1737–1750.
date_created: 2024-06-30T13:58:42Z
date_updated: 2024-06-30T13:58:52Z
department:
- _id: '35'
- _id: '22'
doi: 10.1016/j.comnet.2008.09.007
intvolume: ' 53'
issue: '10'
language:
- iso: eng
page: 1737–1750
publication: Elsevier Computer Networks
publication_identifier:
issn:
- 1389-1286
publisher: Elsevier
status: public
title: A Rule-based System for Programming Self-Organized Sensor and Actor Networks
type: journal_article
user_id: '49428'
volume: 53
year: '2009'
...
---
_id: '54950'
abstract:
- lang: eng
text: The mechanisms by which proteases activate the epithelial sodium channel (ENaC)
are not yet fully understood. We investigated the effect of extracellular proteases
on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of
trypsin increased ENaC whole-oocyte currents by about 8-fold without a concomitant
increase in channel surface expression. The stimulatory effect of trypsin was
preserved in oocytes expressing alphagamma-ENaC, but was abolished in oocytes
expressing alphabeta-ENaC. Thus, the gamma-subunit appears to be essential for
channel activation by extracellular proteases. Site-directed mutagenesis of a
putative prostasin cleavage site in the extracellular loop of the gamma-subunit
revealed that mutating the 181Lys residue to alanine (gammaK181A) increases ENaC
baseline whole-oocyte currents, decreases channel surface expression, and largely
reduces the stimulatory effect of extracellular proteases (trypsin, chymotrypsin
and human neutrophil elastase). In single-channel recordings from outside-out
patches we demonstrated that the gammaK181A mutation essentially abolishes the
activation of near-silent channels by trypsin, while a stimulatory effect of trypsin
on channel gating is preserved. This apparent dual effect of trypsin on channel
gating and on the recruitment of near-silent channels was confirmed by experiments
using the beta518C mutant ENaC which can be converted to a channel with an open
probability of nearly one by exposure to a sulfhydryl reagent. Interestingly,
the gammaK181A mutation results in the spontaneous appearance of a 67 kDa fragment
of the gamma-subunit in the plasma membrane which can be prevented by a furin
inhibitor and also occurs after channel activation by extracellular trypsin. This
suggests that the mutation promotes channel cleavage and activation by endogenous
proteases. This would lower the pool of near-silent channels and explain the constitutive
activation and reduced responsiveness of the mutant channel to extracellular proteases.
We conclude that the mutated site (K181A) affects a region in the gamma-subunit
of ENaC that is functionally important for the activation of near-silent channels
by extracellular proteases.
author:
- first_name: Alexei
full_name: Diakov, Alexei
last_name: Diakov
- first_name: Katarzyna
full_name: Bera, Katarzyna
last_name: Bera
- first_name: Marianna
full_name: Mokrushina, Marianna
last_name: Mokrushina
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Christoph
full_name: Korbmacher, Christoph
last_name: Korbmacher
citation:
ama: Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C. Cleavage in the γ-subunit
of the epithelial sodium channel (ENaC) plays an important role in the proteolytic
activation of near-silent channels. The Journal of Physiology. 2008;586(19):4587–4608.
doi:10.1113/jphysiol.2008.154435
apa: Diakov, A., Bera, K., Mokrushina, M., Krueger, B., & Korbmacher, C. (2008).
Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important
role in the proteolytic activation of near-silent channels. The Journal of
Physiology, 586(19), 4587–4608. https://doi.org/10.1113/jphysiol.2008.154435
bibtex: '@article{Diakov_Bera_Mokrushina_Krueger_Korbmacher_2008, title={Cleavage
in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role
in the proteolytic activation of near-silent channels}, volume={586}, DOI={10.1113/jphysiol.2008.154435},
number={19}, journal={The Journal of Physiology}, publisher={Wiley}, author={Diakov,
Alexei and Bera, Katarzyna and Mokrushina, Marianna and Krueger, Bettina and Korbmacher,
Christoph}, year={2008}, pages={4587–4608} }'
chicago: 'Diakov, Alexei, Katarzyna Bera, Marianna Mokrushina, Bettina Krueger,
and Christoph Korbmacher. “Cleavage in the γ-Subunit of the Epithelial Sodium
Channel (ENaC) Plays an Important Role in the Proteolytic Activation of near-Silent
Channels.” The Journal of Physiology 586, no. 19 (2008): 4587–4608. https://doi.org/10.1113/jphysiol.2008.154435.'
ieee: 'A. Diakov, K. Bera, M. Mokrushina, B. Krueger, and C. Korbmacher, “Cleavage
in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role
in the proteolytic activation of near-silent channels,” The Journal of Physiology,
vol. 586, no. 19, pp. 4587–4608, 2008, doi: 10.1113/jphysiol.2008.154435.'
mla: Diakov, Alexei, et al. “Cleavage in the γ-Subunit of the Epithelial Sodium
Channel (ENaC) Plays an Important Role in the Proteolytic Activation of near-Silent
Channels.” The Journal of Physiology, vol. 586, no. 19, Wiley, 2008, pp.
4587–4608, doi:10.1113/jphysiol.2008.154435.
short: A. Diakov, K. Bera, M. Mokrushina, B. Krueger, C. Korbmacher, The Journal
of Physiology 586 (2008) 4587–4608.
date_created: 2024-06-30T14:02:04Z
date_updated: 2024-07-11T05:13:55Z
department:
- _id: '35'
- _id: '22'
doi: 10.1113/jphysiol.2008.154435
intvolume: ' 586'
issue: '19'
language:
- iso: eng
page: 4587–4608
publication: The Journal of Physiology
publisher: Wiley
status: public
title: Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an
important role in the proteolytic activation of near-silent channels
type: journal_article
user_id: '1112'
volume: 586
year: '2008'
...
---
_id: '54935'
abstract:
- lang: eng
text: Expression of connective tissue growth factor (CTGF) in endothelial cells
is modulated by shear stress affecting the organization of the cytoskeleton. The
molecular connection between alterations of actin and CTGF expression was investigated
in human umbilical vein endothelial cells (HUVEC) and a microvascular endothelial
cell line. Overexpression of nonpolymerizable monomeric actin R62D interfered
with stress fiber formation in HUVEC and concomitantly reduced immunoreactive
CTGF. In microvascular endothelial cells, flow-dependent upregulation of CTGF
was prevented by this actin mutant. In contrast, overexpression of actin S14C
strengthened filamentous actin and increased CTGF expression. These data indicated
an inverse relationship between CTGF expression and monomeric actin. Coexpression
of the mutant actins and different CTGF promoter constructs revealed an actin-sensitive
site between 3 and 4.5 kb of the CTGF promoter. A CArG-like box at -3791 bp was
responsible for actin-dependent CTGF induction as shown by mutagenesis. Overexpression
of actin S14C activated the nonmutated promoter significantly more strongly than
the mutated promoter. Actin polymerization is regulated by the small GTPase RhoA
and activation of serum response factor (SRF). Overexpression of constitutively
active RhoA or SRF significantly increased CTGF protein synthesis. The 4.5-kb
promoter construct, but not the construct with a mutation in the CArG box, was
activated by SRF or RhoA, providing evidence for a functional role of this site
in CTGF induction. These findings provide novel evidence that monomeric actin
is the connecting link between alterations in the cytoskeleton and CTGF gene expression
and demonstrate the importance of SRF in regulating CTGF transcription.
author:
- first_name: Susanne
full_name: Muehlich, Susanne
last_name: Muehlich
- first_name: Iwona
full_name: Cicha, Iwona
last_name: Cicha
- first_name: Christoph D.
full_name: Garlichs, Christoph D.
last_name: Garlichs
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Guido
full_name: Posern, Guido
last_name: Posern
- first_name: Margarete
full_name: Goppelt-Struebe, Margarete
last_name: Goppelt-Struebe
citation:
ama: Muehlich S, Cicha I, Garlichs CD, Krueger B, Posern G, Goppelt-Struebe M. Actin-dependent
regulation of connective tissue growth factor. American Journal of Physiology-Cell
Physiology. 2007;292(5):C1732–C1738. doi:10.1152/ajpcell.00552.2006
apa: Muehlich, S., Cicha, I., Garlichs, C. D., Krueger, B., Posern, G., & Goppelt-Struebe,
M. (2007). Actin-dependent regulation of connective tissue growth factor. American
Journal of Physiology-Cell Physiology, 292(5), C1732–C1738. https://doi.org/10.1152/ajpcell.00552.2006
bibtex: '@article{Muehlich_Cicha_Garlichs_Krueger_Posern_Goppelt-Struebe_2007, title={Actin-dependent
regulation of connective tissue growth factor}, volume={292}, DOI={10.1152/ajpcell.00552.2006},
number={5}, journal={American Journal of Physiology-Cell Physiology}, publisher={American
Physiological Society}, author={Muehlich, Susanne and Cicha, Iwona and Garlichs,
Christoph D. and Krueger, Bettina and Posern, Guido and Goppelt-Struebe, Margarete},
year={2007}, pages={C1732–C1738} }'
chicago: 'Muehlich, Susanne, Iwona Cicha, Christoph D. Garlichs, Bettina Krueger,
Guido Posern, and Margarete Goppelt-Struebe. “Actin-Dependent Regulation of Connective
Tissue Growth Factor.” American Journal of Physiology-Cell Physiology 292,
no. 5 (2007): C1732–C1738. https://doi.org/10.1152/ajpcell.00552.2006.'
ieee: 'S. Muehlich, I. Cicha, C. D. Garlichs, B. Krueger, G. Posern, and M. Goppelt-Struebe,
“Actin-dependent regulation of connective tissue growth factor,” American Journal
of Physiology-Cell Physiology, vol. 292, no. 5, pp. C1732–C1738, 2007, doi:
10.1152/ajpcell.00552.2006.'
mla: Muehlich, Susanne, et al. “Actin-Dependent Regulation of Connective Tissue
Growth Factor.” American Journal of Physiology-Cell Physiology, vol. 292,
no. 5, American Physiological Society, 2007, pp. C1732–C1738, doi:10.1152/ajpcell.00552.2006.
short: S. Muehlich, I. Cicha, C.D. Garlichs, B. Krueger, G. Posern, M. Goppelt-Struebe,
American Journal of Physiology-Cell Physiology 292 (2007) C1732–C1738.
date_created: 2024-06-30T13:49:55Z
date_updated: 2024-06-30T13:50:05Z
department:
- _id: '35'
- _id: '22'
doi: 10.1152/ajpcell.00552.2006
intvolume: ' 292'
issue: '5'
language:
- iso: eng
page: C1732–C1738
publication: American Journal of Physiology-Cell Physiology
publisher: American Physiological Society
status: public
title: Actin-dependent regulation of connective tissue growth factor
type: journal_article
user_id: '49428'
volume: 292
year: '2007'
...
---
_id: '54946'
abstract:
- lang: eng
text: 'The investigation and the development of self-organizing systems are especially
needed for operation and control in massively distributed systems such as Sensor
and Actor Networks (SANETs). The main issues addressed by self-organization techniques
are scalability, network lifetime, and real-time support. In the literature, biological
principles are often cited as inspirations for technical solutions, especially
in the domain of self-organization. This concept already resulted in a good number
of solutions with significant impact such as ant-based routing and immune system
inspired network security solutions. In this paper, another specific biological
field is investigated: cellular signaling cascades for event-specific reaction
initiated by individual cells in collaboration with their direct neighbors. Information
between cells are transmitted via proteins and result in the cascade of protein–protein
or protein–DNA interactions to produce a specific cellular answer, e.g. the activation
of cells or the transmission of mediators. These processes are programmed in every
individual cell and lead to a coordinated reaction on a higher organization platform.
We transferred these mechanisms to operation and control in SANETs. In particular,
a rule-based processing scheme relying on the main concepts of cellular signaling
cascades has been developed. It is relying on simple local rules and providing
problem specific reaction such as local actuation control and data manipulation.
We describe this Rule-based Sensor Network (RSN) technology and demonstrate comparative
simulation results that show the feasibility of our approach.'
author:
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
- first_name: Isabel
full_name: Dietrich, Isabel
last_name: Dietrich
- first_name: Reinhard
full_name: German, Reinhard
last_name: German
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
citation:
ama: 'Dressler F, Dietrich I, German R, Krueger B. Efficient Operation in Sensor
and Actor Networks Inspired by Cellular Signaling Cascades. In: 1st ACM/ICST
International Conference on Autonomic Computing and Communication Systems (Autonomics
2007). Association for Computing Machinery (ACM); 2007. doi:10.1145/1365562.1365572'
apa: Dressler, F., Dietrich, I., German, R., & Krueger, B. (2007). Efficient
Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades.
1st ACM/ICST International Conference on Autonomic Computing and Communication
Systems (Autonomics 2007). https://doi.org/10.1145/1365562.1365572
bibtex: '@inproceedings{Dressler_Dietrich_German_Krueger_2007, place={Rome, Italy},
title={Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling
Cascades}, DOI={10.1145/1365562.1365572},
booktitle={1st ACM/ICST International Conference on Autonomic Computing and Communication
Systems (Autonomics 2007)}, publisher={Association for Computing Machinery (ACM)},
author={Dressler, Falko and Dietrich, Isabel and German, Reinhard and Krueger,
Bettina}, year={2007} }'
chicago: 'Dressler, Falko, Isabel Dietrich, Reinhard German, and Bettina Krueger.
“Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling
Cascades.” In 1st ACM/ICST International Conference on Autonomic Computing
and Communication Systems (Autonomics 2007). Rome, Italy: Association for
Computing Machinery (ACM), 2007. https://doi.org/10.1145/1365562.1365572.'
ieee: 'F. Dressler, I. Dietrich, R. German, and B. Krueger, “Efficient Operation
in Sensor and Actor Networks Inspired by Cellular Signaling Cascades,” 2007, doi:
10.1145/1365562.1365572.'
mla: Dressler, Falko, et al. “Efficient Operation in Sensor and Actor Networks Inspired
by Cellular Signaling Cascades.” 1st ACM/ICST International Conference on Autonomic
Computing and Communication Systems (Autonomics 2007), Association for Computing
Machinery (ACM), 2007, doi:10.1145/1365562.1365572.
short: 'F. Dressler, I. Dietrich, R. German, B. Krueger, in: 1st ACM/ICST International
Conference on Autonomic Computing and Communication Systems (Autonomics 2007),
Association for Computing Machinery (ACM), Rome, Italy, 2007.'
date_created: 2024-06-30T13:59:18Z
date_updated: 2024-06-30T13:59:29Z
department:
- _id: '35'
- _id: '22'
doi: 10.1145/1365562.1365572
language:
- iso: eng
place: Rome, Italy
publication: 1st ACM/ICST International Conference on Autonomic Computing and Communication
Systems (Autonomics 2007)
publisher: Association for Computing Machinery (ACM)
status: public
title: Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling
Cascades
type: conference
user_id: '49428'
year: '2007'
...
---
_id: '54947'
abstract:
- lang: eng
text: In Wireless Sensor Networks (WSNs), address-based routing approaches often
lead to severe problems due to node mobility, energy-saving sleep-cycles, and
often missing or unreliable address information. Data-centric routing schemes
such as flooding or gossiping solve these problems but may lead to congestion
or starvation. Based on biologically inspired mechanisms known from cellular signaling
pathways, we discovered potentials in enhancing the communication required for
self-organization in network environments suffering from data paths with low reliability
and time variations of the reliability. Using an importance factor for particular
transmissions in combination with feedback loops, the overall quality of the global
system can be increased. The resulting algorithm, Weighted Probabilistic Data
Dissemination (WPDD), includes an inherent adaptation to changing network conditions.
Congestion control is supported as well as prioritized data communication. This
paper outlines the working behavior of WPDD and demonstrates its applicability
based on selected simulation results.
author:
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
- first_name: Reinhard
full_name: German, Reinhard
last_name: German
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
citation:
ama: 'Dressler F, German R, Krueger B. Adaptive Data Dissemination in Sensor Networks
using WPDD. In: IEEE Frontiers in the Convergence of Bioscience and Information
Technologies (FBIT 2007). Institute of Electrical and Electronics Engineers
(IEEE); 2007:827–832. doi:10.1109/FBIT.2007.23'
apa: Dressler, F., German, R., & Krueger, B. (2007). Adaptive Data Dissemination
in Sensor Networks using WPDD. IEEE Frontiers in the Convergence of Bioscience
and Information Technologies (FBIT 2007), 827–832. https://doi.org/10.1109/FBIT.2007.23
bibtex: '@inproceedings{Dressler_German_Krueger_2007, place={Jeju City, South Korea},
title={Adaptive Data Dissemination in Sensor Networks using WPDD}, DOI={10.1109/FBIT.2007.23},
booktitle={IEEE Frontiers in the Convergence of Bioscience and Information Technologies
(FBIT 2007)}, publisher={Institute of Electrical and Electronics Engineers (IEEE)},
author={Dressler, Falko and German, Reinhard and Krueger, Bettina}, year={2007},
pages={827–832} }'
chicago: 'Dressler, Falko, Reinhard German, and Bettina Krueger. “Adaptive Data
Dissemination in Sensor Networks Using WPDD.” In IEEE Frontiers in the Convergence
of Bioscience and Information Technologies (FBIT 2007), 827–832. Jeju City,
South Korea: Institute of Electrical and Electronics Engineers (IEEE), 2007. https://doi.org/10.1109/FBIT.2007.23.'
ieee: 'F. Dressler, R. German, and B. Krueger, “Adaptive Data Dissemination in Sensor
Networks using WPDD,” in IEEE Frontiers in the Convergence of Bioscience and
Information Technologies (FBIT 2007), 2007, pp. 827–832, doi: 10.1109/FBIT.2007.23.'
mla: Dressler, Falko, et al. “Adaptive Data Dissemination in Sensor Networks Using
WPDD.” IEEE Frontiers in the Convergence of Bioscience and Information Technologies
(FBIT 2007), Institute of Electrical and Electronics Engineers (IEEE), 2007,
pp. 827–832, doi:10.1109/FBIT.2007.23.
short: 'F. Dressler, R. German, B. Krueger, in: IEEE Frontiers in the Convergence
of Bioscience and Information Technologies (FBIT 2007), Institute of Electrical
and Electronics Engineers (IEEE), Jeju City, South Korea, 2007, pp. 827–832.'
date_created: 2024-06-30T13:59:56Z
date_updated: 2024-06-30T14:00:05Z
department:
- _id: '35'
- _id: '22'
doi: 10.1109/FBIT.2007.23
language:
- iso: eng
page: 827–832
place: Jeju City, South Korea
publication: IEEE Frontiers in the Convergence of Bioscience and Information Technologies
(FBIT 2007)
publisher: Institute of Electrical and Electronics Engineers (IEEE)
status: public
title: Adaptive Data Dissemination in Sensor Networks using WPDD
type: conference
user_id: '49428'
year: '2007'
...
---
_id: '54936'
abstract:
- lang: eng
text: The role of glomerular endothelial cells in kidney fibrosis remains incompletely
understood. While endothelia are indispensable for repair of acute damage, they
can produce extracellular matrix proteins and profibrogenic cytokines that promote
fibrogenesis. We used a murine cell line with all features of glomerular endothelial
cells (glEND.2), which dissected the effects of vascular endothelial growth factor
(VEGF) on cell migration, proliferation, and profibrogenic cytokine production.
VEGF dose-dependently induced glEND.2 cell migration and proliferation, accompanied
by up-regulation of VEGFR-2 phosphorylation and mRNA expression. VEGF induced
a profibrogenic gene expression profile, including up-regulation of TGF-beta1
mRNA, enhanced TGF-beta1 secretion, and bioactivity. VEGF-induced endothelial
cell migration and TGF-beta1 induction were mediated by the phosphatidyl-inositol-3
kinase pathway, while proliferation was dependent on the Erk1/2 MAP kinase pathway.
This suggests that differential modulation of glomerular angiogenesis by selective
inhibition of the two identified VEGF-induced signaling pathways could be a therapeutic
approach to treat kidney fibrosis.
author:
- first_name: Zhao-Dong
full_name: Li, Zhao-Dong
last_name: Li
- first_name: Jens Peter
full_name: Bork, Jens Peter
last_name: Bork
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Eleonora
full_name: Patsenker, Eleonora
last_name: Patsenker
- first_name: Anja
full_name: Schulze-Krebs, Anja
last_name: Schulze-Krebs
- first_name: Eckhart G.
full_name: Hahn, Eckhart G.
last_name: Hahn
- first_name: Detlef
full_name: Schuppan, Detlef
last_name: Schuppan
citation:
ama: Li Z-D, Bork JP, Krueger B, et al. VEGF induces proliferation, migration, and
TGF-$\beta$1 expression in mouse glomerular endothelial cells via mitogen-activated
protein kinase and phosphatidylinositol 3-kinase. Biochemical and Biophysical
Research Communications. 2005;334(4):1049–1060. doi:10.1016/j.bbrc.2005.07.005
apa: Li, Z.-D., Bork, J. P., Krueger, B., Patsenker, E., Schulze-Krebs, A., Hahn,
E. G., & Schuppan, D. (2005). VEGF induces proliferation, migration, and TGF-$\beta$1
expression in mouse glomerular endothelial cells via mitogen-activated protein
kinase and phosphatidylinositol 3-kinase. Biochemical and Biophysical Research
Communications, 334(4), 1049–1060. https://doi.org/10.1016/j.bbrc.2005.07.005
bibtex: '@article{Li_Bork_Krueger_Patsenker_Schulze-Krebs_Hahn_Schuppan_2005, title={VEGF
induces proliferation, migration, and TGF-$\beta$1 expression in mouse glomerular
endothelial cells via mitogen-activated protein kinase and phosphatidylinositol
3-kinase}, volume={334}, DOI={10.1016/j.bbrc.2005.07.005},
number={4}, journal={Biochemical and Biophysical Research Communications}, publisher={Elsevier},
author={Li, Zhao-Dong and Bork, Jens Peter and Krueger, Bettina and Patsenker,
Eleonora and Schulze-Krebs, Anja and Hahn, Eckhart G. and Schuppan, Detlef}, year={2005},
pages={1049–1060} }'
chicago: 'Li, Zhao-Dong, Jens Peter Bork, Bettina Krueger, Eleonora Patsenker, Anja
Schulze-Krebs, Eckhart G. Hahn, and Detlef Schuppan. “VEGF Induces Proliferation,
Migration, and TGF-$\beta$1 Expression in Mouse Glomerular Endothelial Cells via
Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase.” Biochemical
and Biophysical Research Communications 334, no. 4 (2005): 1049–1060. https://doi.org/10.1016/j.bbrc.2005.07.005.'
ieee: 'Z.-D. Li et al., “VEGF induces proliferation, migration, and TGF-$\beta$1
expression in mouse glomerular endothelial cells via mitogen-activated protein
kinase and phosphatidylinositol 3-kinase,” Biochemical and Biophysical Research
Communications, vol. 334, no. 4, pp. 1049–1060, 2005, doi: 10.1016/j.bbrc.2005.07.005.'
mla: Li, Zhao-Dong, et al. “VEGF Induces Proliferation, Migration, and TGF-$\beta$1
Expression in Mouse Glomerular Endothelial Cells via Mitogen-Activated Protein
Kinase and Phosphatidylinositol 3-Kinase.” Biochemical and Biophysical Research
Communications, vol. 334, no. 4, Elsevier, 2005, pp. 1049–1060, doi:10.1016/j.bbrc.2005.07.005.
short: Z.-D. Li, J.P. Bork, B. Krueger, E. Patsenker, A. Schulze-Krebs, E.G. Hahn,
D. Schuppan, Biochemical and Biophysical Research Communications 334 (2005) 1049–1060.
date_created: 2024-06-30T13:50:32Z
date_updated: 2024-06-30T13:50:44Z
department:
- _id: '35'
- _id: '22'
doi: 10.1016/j.bbrc.2005.07.005
intvolume: ' 334'
issue: '4'
language:
- iso: eng
page: 1049–1060
publication: Biochemical and Biophysical Research Communications
publisher: Elsevier
status: public
title: VEGF induces proliferation, migration, and TGF-$\beta$1 expression in mouse
glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol
3-kinase
type: journal_article
user_id: '49428'
volume: 334
year: '2005'
...
---
_id: '54941'
abstract:
- lang: eng
text: Autonomous networking has become the buzzword for attempts of building high-scalable
network architectures, which are self-organizing, self-maintaining and self-healing.
Few of these approaches were successful and none has shown to provide all the
promised functions. We try to study the processes in computer networks using molecular
processes as the paradigm. This novel approach shows many similarities between
computer networking and cellular mechanisms. In this paper, we focus on the area
of network security as one research area with high demand for high-scalable mechanisms
providing the needed functionality. After identifying similarities between nature
and technology, we discuss potential research domains, which are high potentials
for learning directly from molecular biology using the example of security threats
in communication networks. We see the proposed mechanism as a generic approach
for autonomous networking. The countermeasures against attacks in computer networks
are only a special example to introduce the mechanisms.
author:
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
citation:
ama: 'Krueger B, Dressler F. Molecular Processes as a Basis for Autonomous Networking.
IPSI Transactions on Advances Research: Issues in Computer Science and Engineering.
2005;1(1):43–50.'
apa: 'Krueger, B., & Dressler, F. (2005). Molecular Processes as a Basis for
Autonomous Networking. IPSI Transactions on Advances Research: Issues in Computer
Science and Engineering, 1(1), 43–50.'
bibtex: '@article{Krueger_Dressler_2005, title={Molecular Processes as a Basis for
Autonomous Networking}, volume={1}, number={1}, journal={IPSI Transactions on
Advances Research: Issues in Computer Science and Engineering}, publisher={IPSI},
author={Krueger, Bettina and Dressler, Falko}, year={2005}, pages={43–50} }'
chicago: 'Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis
for Autonomous Networking.” IPSI Transactions on Advances Research: Issues
in Computer Science and Engineering 1, no. 1 (2005): 43–50.'
ieee: 'B. Krueger and F. Dressler, “Molecular Processes as a Basis for Autonomous
Networking,” IPSI Transactions on Advances Research: Issues in Computer Science
and Engineering, vol. 1, no. 1, pp. 43–50, 2005.'
mla: 'Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis for
Autonomous Networking.” IPSI Transactions on Advances Research: Issues in Computer
Science and Engineering, vol. 1, no. 1, IPSI, 2005, pp. 43–50.'
short: 'B. Krueger, F. Dressler, IPSI Transactions on Advances Research: Issues
in Computer Science and Engineering 1 (2005) 43–50.'
date_created: 2024-06-30T13:56:26Z
date_updated: 2024-06-30T13:56:35Z
department:
- _id: '35'
- _id: '22'
intvolume: ' 1'
issue: '1'
language:
- iso: eng
page: 43–50
publication: 'IPSI Transactions on Advances Research: Issues in Computer Science and
Engineering'
publisher: IPSI
status: public
title: Molecular Processes as a Basis for Autonomous Networking
type: journal_article
user_id: '49428'
volume: 1
year: '2005'
...
---
_id: '54948'
abstract:
- lang: eng
text: Bio-inspired communication methodologies promise to enable more scalable self-organizing
network infrastructures. Especially in the area of mobile ad hoc sensor networks,
such solutions are required in order to qualify them for simplified development
and deployment based on autonomously evolving mechanisms to work on global tasks,
i.e. to show an emergent behavior. In this paper, we introduce the ongoing research
of our Autonomic Networking group focused on the developments on efficient data
dissemination in sensor networks. A particular example of how to study biological
processes and to adapt the results in communication networks, the feedback loop
mechanism, depicts the potentials of this research area.
author:
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Gerhard
full_name: Fuchs, Gerhard
last_name: Fuchs
- first_name: Reinhard
full_name: German, Reinhard
last_name: German
citation:
ama: 'Dressler F, Krueger B, Fuchs G, German R. Self-Organization in Sensor Networks
using Bio-Inspired Mechanisms. In: 18th ACM/GI/ITG International Conference
on Architecture of Computing Systems - System Aspects in Organic and Pervasive
Computing (ARCS 2005): Workshop Self-Organization and Emergence. Springer;
2005:139–144.'
apa: 'Dressler, F., Krueger, B., Fuchs, G., & German, R. (2005). Self-Organization
in Sensor Networks using Bio-Inspired Mechanisms. 18th ACM/GI/ITG International
Conference on Architecture of Computing Systems - System Aspects in Organic and
Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence,
139–144.'
bibtex: '@inproceedings{Dressler_Krueger_Fuchs_German_2005, place={Innsbruck, Austria},
title={Self-Organization in Sensor Networks using Bio-Inspired Mechanisms}, booktitle={18th
ACM/GI/ITG International Conference on Architecture of Computing Systems - System
Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization
and Emergence}, publisher={Springer}, author={Dressler, Falko and Krueger, Bettina
and Fuchs, Gerhard and German, Reinhard}, year={2005}, pages={139–144} }'
chicago: 'Dressler, Falko, Bettina Krueger, Gerhard Fuchs, and Reinhard German.
“Self-Organization in Sensor Networks Using Bio-Inspired Mechanisms.” In 18th
ACM/GI/ITG International Conference on Architecture of Computing Systems - System
Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop Self-Organization
and Emergence, 139–144. Innsbruck, Austria: Springer, 2005.'
ieee: 'F. Dressler, B. Krueger, G. Fuchs, and R. German, “Self-Organization in Sensor
Networks using Bio-Inspired Mechanisms,” in 18th ACM/GI/ITG International Conference
on Architecture of Computing Systems - System Aspects in Organic and Pervasive
Computing (ARCS 2005): Workshop Self-Organization and Emergence, 2005, pp.
139–144.'
mla: 'Dressler, Falko, et al. “Self-Organization in Sensor Networks Using Bio-Inspired
Mechanisms.” 18th ACM/GI/ITG International Conference on Architecture of Computing
Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop
Self-Organization and Emergence, Springer, 2005, pp. 139–144.'
short: 'F. Dressler, B. Krueger, G. Fuchs, R. German, in: 18th ACM/GI/ITG International
Conference on Architecture of Computing Systems - System Aspects in Organic and
Pervasive Computing (ARCS 2005): Workshop Self-Organization and Emergence, Springer,
Innsbruck, Austria, 2005, pp. 139–144.'
date_created: 2024-06-30T14:01:12Z
date_updated: 2024-06-30T14:01:23Z
department:
- _id: '35'
- _id: '22'
language:
- iso: eng
page: 139–144
place: Innsbruck, Austria
publication: '18th ACM/GI/ITG International Conference on Architecture of Computing
Systems - System Aspects in Organic and Pervasive Computing (ARCS 2005): Workshop
Self-Organization and Emergence'
publisher: Springer
status: public
title: Self-Organization in Sensor Networks using Bio-Inspired Mechanisms
type: conference
user_id: '49428'
year: '2005'
...
---
_id: '54143'
abstract:
- lang: eng
text: Besides to classical research area of bioinformatics, the turn to nature for
solutions to technological questions has brought us many unforeseen great concepts.
This encouraging course seems to hold on for many aspects in technology. Many
efforts were made in the area of computer technology employing mechanisms known
from biological systems. The most known examples are evolutionary algorithms and
the artificial immune system. One application is in network security, e.g. for
the search for viruses and worms, where the immune system was used as an inspiration.In
contrast, the focus of our group lays on trying to map the cellular and molecular
biology to networking architectures. Recently, it was shown that the known approaches
to study effects in computer networking, especially methods to analyze the behavior
of large scale networks suffer from many presumptions. We try to study this behavior
by analyzing the internal functioning of network components as well as there interactions
in comparison with cellular systems and the associated intra and extra cellular
signaling pathways.The main focus of this work is to show the similarities of
computer networks and cellular systems. Based on the knowledge about cellular
metabolism, new concepts for the behavior patterns of routers, monitor systems,
and firewalls can be deduced and the efficiency of individual sub-systems can
be increased. Focusing on examples of hot topics in the computer society, i.e.
network security, potential solutions motivated by cellular behavior are currently
studied and, hopefully, will soon bring new results in these areas.Independently
from these examinations, we try to show the power of our novel approach by introducing
the basic mechanisms and interactions as well as a self-evident application. Doing
this, we must keep in mind that the deeper the parallels between biology and technology,
the more important it is to map the corresponding elements correctly.
author:
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
citation:
ama: 'Dressler F, Krueger B. Cell biology as a key to computer networking. In: German
Conference on Bioinformatics 2004 (GCB 2004), Poster Session. ; 2004.'
apa: Dressler, F., & Krueger, B. (2004). Cell biology as a key to computer networking.
German Conference on Bioinformatics 2004 (GCB 2004), Poster Session.
bibtex: '@inproceedings{Dressler_Krueger_2004, place={Bielefeld, Germany}, title={Cell
biology as a key to computer networking}, booktitle={German Conference on Bioinformatics
2004 (GCB 2004), Poster Session}, author={Dressler, Falko and Krueger, Bettina},
year={2004} }'
chicago: Dressler, Falko, and Bettina Krueger. “Cell Biology as a Key to Computer
Networking.” In German Conference on Bioinformatics 2004 (GCB 2004), Poster
Session. Bielefeld, Germany, 2004.
ieee: F. Dressler and B. Krueger, “Cell biology as a key to computer networking,”
2004.
mla: Dressler, Falko, and Bettina Krueger. “Cell Biology as a Key to Computer Networking.”
German Conference on Bioinformatics 2004 (GCB 2004), Poster Session, 2004.
short: 'F. Dressler, B. Krueger, in: German Conference on Bioinformatics 2004 (GCB
2004), Poster Session, Bielefeld, Germany, 2004.'
date_created: 2024-05-10T07:40:39Z
date_updated: 2024-06-30T13:55:23Z
department:
- _id: '35'
- _id: '22'
language:
- iso: eng
place: Bielefeld, Germany
publication: German Conference on Bioinformatics 2004 (GCB 2004), Poster Session
status: public
title: Cell biology as a key to computer networking
type: conference
user_id: '49428'
year: '2004'
...
---
_id: '54940'
abstract:
- lang: eng
text: Autonomous networking has become the buzzword for attempts of building high-scalable
network architectures, which are self-organizing, self-maintaining and self-healing.
Few of these approaches were successful and none has shown to provide all the
promised functions. We try to study the processes in computer networks using molecular
processes as the paradigm. This novel approach shows many similarities between
computer networking and cellular mechanisms. In this paper, we focus on the area
of network security as one research area with high demand for high-scalable mechanisms
providing the needed functionality. After identifying similarities between nature
and technology, we discuss potential research domains, which are high potentials
for learning directly from biology at the example of security attacks in networks.
We see the proposed mechanism as a generic approach for autonomous networking.
The countermeasures against attacks in computer networks are only a special example
to introduce the mechanisms.
author:
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Falko
full_name: Dressler, Falko
last_name: Dressler
citation:
ama: 'Krueger B, Dressler F. Molecular Processes as a Basis for Autonomous Networking.
In: International IPSI Stockholm Conference: Symposium on Challenges in the
Internet and Interdisciplinary Research (IPSI 2004). ; 2004.'
apa: 'Krueger, B., & Dressler, F. (2004). Molecular Processes as a Basis for
Autonomous Networking. International IPSI Stockholm Conference: Symposium on
Challenges in the Internet and Interdisciplinary Research (IPSI 2004).'
bibtex: '@inproceedings{Krueger_Dressler_2004, place={Stockholm, Sweden}, title={Molecular
Processes as a Basis for Autonomous Networking}, booktitle={International IPSI
Stockholm Conference: Symposium on Challenges in the Internet and Interdisciplinary
Research (IPSI 2004)}, author={Krueger, Bettina and Dressler, Falko}, year={2004}
}'
chicago: 'Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis
for Autonomous Networking.” In International IPSI Stockholm Conference: Symposium
on Challenges in the Internet and Interdisciplinary Research (IPSI 2004).
Stockholm, Sweden, 2004.'
ieee: B. Krueger and F. Dressler, “Molecular Processes as a Basis for Autonomous
Networking,” 2004.
mla: 'Krueger, Bettina, and Falko Dressler. “Molecular Processes as a Basis for
Autonomous Networking.” International IPSI Stockholm Conference: Symposium
on Challenges in the Internet and Interdisciplinary Research (IPSI 2004),
2004.'
short: 'B. Krueger, F. Dressler, in: International IPSI Stockholm Conference: Symposium
on Challenges in the Internet and Interdisciplinary Research (IPSI 2004), Stockholm,
Sweden, 2004.'
date_created: 2024-06-30T13:55:57Z
date_updated: 2024-06-30T13:56:07Z
department:
- _id: '35'
- _id: '22'
language:
- iso: eng
place: Stockholm, Sweden
publication: 'International IPSI Stockholm Conference: Symposium on Challenges in
the Internet and Interdisciplinary Research (IPSI 2004)'
status: public
title: Molecular Processes as a Basis for Autonomous Networking
type: conference
user_id: '49428'
year: '2004'
...