---
_id: '59616'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:p>The activation of C(<jats:italic>sp</jats:italic><jats:sup>3</jats:sup>)−F
    bonds by the commercially available catalyst B(C<jats:sub>6</jats:sub>F<jats:sub>5</jats:sub>)<jats:sub>3</jats:sub>
    is reported and applied in reactions with arenes, allylic, vinylic and acetylenic
    silanes, and olefins to achieve a variety of C−C bond formations (45 examples).</jats:p>
author:
- first_name: Axel
  full_name: Hoppe, Axel
  id: '62844'
  last_name: Hoppe
- first_name: Arne J.
  full_name: Stepen, Arne J.
  last_name: Stepen
- first_name: Laura
  full_name: Köring, Laura
  last_name: Köring
- first_name: Jan
  full_name: Paradies, Jan
  id: '53339'
  last_name: Paradies
  orcid: 0000-0002-3698-668X
citation:
  ama: Hoppe A, Stepen AJ, Köring L, Paradies J. Tris(pentafluorophenyl)borane‐Catalyzed
    Functionalization of Benzylic C−F Bonds. <i>Advanced Synthesis &#38;amp; Catalysis</i>.
    2024;366(13):2933-2938. doi:<a href="https://doi.org/10.1002/adsc.202400511">10.1002/adsc.202400511</a>
  apa: Hoppe, A., Stepen, A. J., Köring, L., &#38; Paradies, J. (2024). Tris(pentafluorophenyl)borane‐Catalyzed
    Functionalization of Benzylic C−F Bonds. <i>Advanced Synthesis &#38;amp; Catalysis</i>,
    <i>366</i>(13), 2933–2938. <a href="https://doi.org/10.1002/adsc.202400511">https://doi.org/10.1002/adsc.202400511</a>
  bibtex: '@article{Hoppe_Stepen_Köring_Paradies_2024, title={Tris(pentafluorophenyl)borane‐Catalyzed
    Functionalization of Benzylic C−F Bonds}, volume={366}, DOI={<a href="https://doi.org/10.1002/adsc.202400511">10.1002/adsc.202400511</a>},
    number={13}, journal={Advanced Synthesis &#38;amp; Catalysis}, publisher={Wiley},
    author={Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan},
    year={2024}, pages={2933–2938} }'
  chicago: 'Hoppe, Axel, Arne J. Stepen, Laura Köring, and Jan Paradies. “Tris(Pentafluorophenyl)Borane‐Catalyzed
    Functionalization of Benzylic C−F Bonds.” <i>Advanced Synthesis &#38;amp; Catalysis</i>
    366, no. 13 (2024): 2933–38. <a href="https://doi.org/10.1002/adsc.202400511">https://doi.org/10.1002/adsc.202400511</a>.'
  ieee: 'A. Hoppe, A. J. Stepen, L. Köring, and J. Paradies, “Tris(pentafluorophenyl)borane‐Catalyzed
    Functionalization of Benzylic C−F Bonds,” <i>Advanced Synthesis &#38;amp; Catalysis</i>,
    vol. 366, no. 13, pp. 2933–2938, 2024, doi: <a href="https://doi.org/10.1002/adsc.202400511">10.1002/adsc.202400511</a>.'
  mla: Hoppe, Axel, et al. “Tris(Pentafluorophenyl)Borane‐Catalyzed Functionalization
    of Benzylic C−F Bonds.” <i>Advanced Synthesis &#38;amp; Catalysis</i>, vol. 366,
    no. 13, Wiley, 2024, pp. 2933–38, doi:<a href="https://doi.org/10.1002/adsc.202400511">10.1002/adsc.202400511</a>.
  short: A. Hoppe, A.J. Stepen, L. Köring, J. Paradies, Advanced Synthesis &#38;amp;
    Catalysis 366 (2024) 2933–2938.
date_created: 2025-04-22T05:59:08Z
date_updated: 2025-04-22T06:11:59Z
department:
- _id: '389'
doi: 10.1002/adsc.202400511
intvolume: '       366'
issue: '13'
keyword:
- fluoride
- bond activation
- borane
- Lewis acid
- C-C bond formation
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.202400511
oa: '1'
page: 2933-2938
publication: Advanced Synthesis &amp; Catalysis
publication_identifier:
  issn:
  - 1615-4150
  - 1615-4169
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds
type: journal_article
user_id: '62844'
volume: 366
year: '2024'
...
---
_id: '59617'
abstract:
- lang: eng
  text: '<jats:p>There is an increasing interest in sensing applications for a variety
    of analytes in aqueous environments, as conventional methods do not work reliably
    under humid conditions or they require complex equipment with experienced operators.
    Hydrogel sensors are easy to fabricate, are incredibly sensitive, and have broad
    dynamic ranges. Experiments on their robustness, reliability, and reusability
    have indicated the possible long-term applications of these systems in a variety
    of fields, including disease diagnosis, detection of pharmaceuticals, and in environmental
    testing. It is possible to produce hydrogels, which, upon sensing a specific analyte,
    can adsorb it onto their 3D-structure and can therefore be used to remove them
    from a given environment. High specificity can be obtained by using molecularly
    imprinted polymers. Typical detection principles involve optical methods including
    fluorescence and chemiluminescence, and volume changes in colloidal photonic crystals,
    as well as electrochemical methods. Here, we explore the current research utilizing
    hydrogel-based sensors in three main areas: (1) biomedical applications, (2) for
    detecting and quantifying pharmaceuticals of interest, and (3) detecting and quantifying
    environmental contaminants in aqueous environments.</jats:p>'
article_number: '768'
author:
- first_name: Katharina
  full_name: Völlmecke, Katharina
  last_name: Völlmecke
- first_name: Rowshon
  full_name: Afroz, Rowshon
  last_name: Afroz
- first_name: Sascha
  full_name: Bierbach, Sascha
  last_name: Bierbach
- first_name: Lee Josephine
  full_name: Brenker, Lee Josephine
  last_name: Brenker
- first_name: Sebastian
  full_name: Frücht, Sebastian
  last_name: Frücht
- first_name: Alexandra
  full_name: Glass, Alexandra
  last_name: Glass
- first_name: Ryland
  full_name: Giebelhaus, Ryland
  last_name: Giebelhaus
- first_name: Axel
  full_name: Hoppe, Axel
  id: '62844'
  last_name: Hoppe
- first_name: Karen
  full_name: Kanemaru, Karen
  last_name: Kanemaru
- first_name: Michal
  full_name: Lazarek, Michal
  last_name: Lazarek
- first_name: Lukas
  full_name: Rabbe, Lukas
  last_name: Rabbe
- first_name: Longfei
  full_name: Song, Longfei
  last_name: Song
- first_name: Andrea
  full_name: Velasco Suarez, Andrea
  last_name: Velasco Suarez
- first_name: Shuang
  full_name: Wu, Shuang
  last_name: Wu
- first_name: Michael
  full_name: Serpe, Michael
  last_name: Serpe
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Völlmecke K, Afroz R, Bierbach S, et al. Hydrogel-Based Biosensors. <i>Gels</i>.
    2022;8(12). doi:<a href="https://doi.org/10.3390/gels8120768">10.3390/gels8120768</a>
  apa: Völlmecke, K., Afroz, R., Bierbach, S., Brenker, L. J., Frücht, S., Glass,
    A., Giebelhaus, R., Hoppe, A., Kanemaru, K., Lazarek, M., Rabbe, L., Song, L.,
    Velasco Suarez, A., Wu, S., Serpe, M., &#38; Kuckling, D. (2022). Hydrogel-Based
    Biosensors. <i>Gels</i>, <i>8</i>(12), Article 768. <a href="https://doi.org/10.3390/gels8120768">https://doi.org/10.3390/gels8120768</a>
  bibtex: '@article{Völlmecke_Afroz_Bierbach_Brenker_Frücht_Glass_Giebelhaus_Hoppe_Kanemaru_Lazarek_et
    al._2022, title={Hydrogel-Based Biosensors}, volume={8}, DOI={<a href="https://doi.org/10.3390/gels8120768">10.3390/gels8120768</a>},
    number={12768}, journal={Gels}, publisher={MDPI AG}, author={Völlmecke, Katharina
    and Afroz, Rowshon and Bierbach, Sascha and Brenker, Lee Josephine and Frücht,
    Sebastian and Glass, Alexandra and Giebelhaus, Ryland and Hoppe, Axel and Kanemaru,
    Karen and Lazarek, Michal and et al.}, year={2022} }'
  chicago: Völlmecke, Katharina, Rowshon Afroz, Sascha Bierbach, Lee Josephine Brenker,
    Sebastian Frücht, Alexandra Glass, Ryland Giebelhaus, et al. “Hydrogel-Based Biosensors.”
    <i>Gels</i> 8, no. 12 (2022). <a href="https://doi.org/10.3390/gels8120768">https://doi.org/10.3390/gels8120768</a>.
  ieee: 'K. Völlmecke <i>et al.</i>, “Hydrogel-Based Biosensors,” <i>Gels</i>, vol.
    8, no. 12, Art. no. 768, 2022, doi: <a href="https://doi.org/10.3390/gels8120768">10.3390/gels8120768</a>.'
  mla: Völlmecke, Katharina, et al. “Hydrogel-Based Biosensors.” <i>Gels</i>, vol.
    8, no. 12, 768, MDPI AG, 2022, doi:<a href="https://doi.org/10.3390/gels8120768">10.3390/gels8120768</a>.
  short: K. Völlmecke, R. Afroz, S. Bierbach, L.J. Brenker, S. Frücht, A. Glass, R.
    Giebelhaus, A. Hoppe, K. Kanemaru, M. Lazarek, L. Rabbe, L. Song, A. Velasco Suarez,
    S. Wu, M. Serpe, D. Kuckling, Gels 8 (2022).
date_created: 2025-04-22T05:59:29Z
date_updated: 2025-04-22T06:12:07Z
department:
- _id: '311'
doi: 10.3390/gels8120768
intvolume: '         8'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.mdpi.com/2310-2861/8/12/768
oa: '1'
publication: Gels
publication_identifier:
  issn:
  - 2310-2861
publication_status: published
publisher: MDPI AG
quality_controlled: '1'
status: public
title: Hydrogel-Based Biosensors
type: journal_article
user_id: '62844'
volume: 8
year: '2022'
...
---
_id: '59619'
abstract:
- lang: eng
  text: "<jats:title>Abstract</jats:title><jats:p>A frustrated Lewis pair‐catalyzed
    hydroboration of aromatic and aliphatic nitriles was developed. The catalyst provides
    the primary amines in high yields of 77–99% with catalyst loading as low as 2 mol%.
    The reaction displays high functional group tolerance towards esters, amides,
    nitro groups and aliphatic halides. The addition of the diborylated amines to
    ethyl 3‐phenylpropiolate proceeds with Z‐selectivity with d.r. of &gt;99:1 in
    77–90% yield over two steps. The reaction mechanism was investigated by control
    and computational experiments.</jats:p><jats:p><jats:boxed-text content-type=\"graphic\"
    position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\"
    mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\"
    xlink:href=\"graphic/adsc202200525-toc-0001-m.png\"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text>\r\n</jats:p>"
author:
- first_name: Benedikt
  full_name: Sieland, Benedikt
  last_name: Sieland
- first_name: Axel
  full_name: Hoppe, Axel
  id: '62844'
  last_name: Hoppe
- first_name: Arne J.
  full_name: Stepen, Arne J.
  last_name: Stepen
- first_name: Jan
  full_name: Paradies, Jan
  id: '53339'
  last_name: Paradies
  orcid: 0000-0002-3698-668X
citation:
  ama: 'Sieland B, Hoppe A, Stepen AJ, Paradies J. Frustrated Lewis Pair‐Catalyzed
    Hydroboration of Nitriles: FLP Versus Borenium Catalysis. <i>Advanced Synthesis
    &#38;amp; Catalysis</i>. 2022;364(18):3143-3148. doi:<a href="https://doi.org/10.1002/adsc.202200525">10.1002/adsc.202200525</a>'
  apa: 'Sieland, B., Hoppe, A., Stepen, A. J., &#38; Paradies, J. (2022). Frustrated
    Lewis Pair‐Catalyzed Hydroboration of Nitriles: FLP Versus Borenium Catalysis.
    <i>Advanced Synthesis &#38;amp; Catalysis</i>, <i>364</i>(18), 3143–3148. <a href="https://doi.org/10.1002/adsc.202200525">https://doi.org/10.1002/adsc.202200525</a>'
  bibtex: '@article{Sieland_Hoppe_Stepen_Paradies_2022, title={Frustrated Lewis Pair‐Catalyzed
    Hydroboration of Nitriles: FLP Versus Borenium Catalysis}, volume={364}, DOI={<a
    href="https://doi.org/10.1002/adsc.202200525">10.1002/adsc.202200525</a>}, number={18},
    journal={Advanced Synthesis &#38;amp; Catalysis}, publisher={Wiley}, author={Sieland,
    Benedikt and Hoppe, Axel and Stepen, Arne J. and Paradies, Jan}, year={2022},
    pages={3143–3148} }'
  chicago: 'Sieland, Benedikt, Axel Hoppe, Arne J. Stepen, and Jan Paradies. “Frustrated
    Lewis Pair‐Catalyzed Hydroboration of Nitriles: FLP Versus Borenium Catalysis.”
    <i>Advanced Synthesis &#38;amp; Catalysis</i> 364, no. 18 (2022): 3143–48. <a
    href="https://doi.org/10.1002/adsc.202200525">https://doi.org/10.1002/adsc.202200525</a>.'
  ieee: 'B. Sieland, A. Hoppe, A. J. Stepen, and J. Paradies, “Frustrated Lewis Pair‐Catalyzed
    Hydroboration of Nitriles: FLP Versus Borenium Catalysis,” <i>Advanced Synthesis
    &#38;amp; Catalysis</i>, vol. 364, no. 18, pp. 3143–3148, 2022, doi: <a href="https://doi.org/10.1002/adsc.202200525">10.1002/adsc.202200525</a>.'
  mla: 'Sieland, Benedikt, et al. “Frustrated Lewis Pair‐Catalyzed Hydroboration of
    Nitriles: FLP Versus Borenium Catalysis.” <i>Advanced Synthesis &#38;amp; Catalysis</i>,
    vol. 364, no. 18, Wiley, 2022, pp. 3143–48, doi:<a href="https://doi.org/10.1002/adsc.202200525">10.1002/adsc.202200525</a>.'
  short: B. Sieland, A. Hoppe, A.J. Stepen, J. Paradies, Advanced Synthesis &#38;amp;
    Catalysis 364 (2022) 3143–3148.
date_created: 2025-04-22T06:01:56Z
date_updated: 2025-04-22T06:12:05Z
department:
- _id: '389'
doi: 10.1002/adsc.202200525
intvolume: '       364'
issue: '18'
keyword:
- hydroboration
- nitrile
- amine
- frustrated Lewis pair
- density functional theory
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.202200525
oa: '1'
page: 3143-3148
publication: Advanced Synthesis &amp; Catalysis
publication_identifier:
  issn:
  - 1615-4150
  - 1615-4169
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'Frustrated Lewis Pair‐Catalyzed Hydroboration of Nitriles: FLP Versus Borenium
  Catalysis'
type: journal_article
user_id: '62844'
volume: 364
year: '2022'
...
---
_id: '59620'
article_type: original
author:
- first_name: Tarik
  full_name: Rust, Tarik
  last_name: Rust
- first_name: Dimitri
  full_name: Jung, Dimitri
  last_name: Jung
- first_name: Axel
  full_name: Hoppe, Axel
  id: '62844'
  last_name: Hoppe
- first_name: Timo
  full_name: Schoppa, Timo
  last_name: Schoppa
- first_name: Klaus
  full_name: Langer, Klaus
  last_name: Langer
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Rust T, Jung D, Hoppe A, Schoppa T, Langer K, Kuckling D. Backbone-Degradable
    (Co-)Polymers for Light-Triggered Drug Delivery. <i>ACS Applied Polymer Materials</i>.
    2021;3(8):3831-3842. doi:<a href="https://doi.org/10.1021/acsapm.1c00411">10.1021/acsapm.1c00411</a>
  apa: Rust, T., Jung, D., Hoppe, A., Schoppa, T., Langer, K., &#38; Kuckling, D.
    (2021). Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery. <i>ACS
    Applied Polymer Materials</i>, <i>3</i>(8), 3831–3842. <a href="https://doi.org/10.1021/acsapm.1c00411">https://doi.org/10.1021/acsapm.1c00411</a>
  bibtex: '@article{Rust_Jung_Hoppe_Schoppa_Langer_Kuckling_2021, title={Backbone-Degradable
    (Co-)Polymers for Light-Triggered Drug Delivery}, volume={3}, DOI={<a href="https://doi.org/10.1021/acsapm.1c00411">10.1021/acsapm.1c00411</a>},
    number={8}, journal={ACS Applied Polymer Materials}, publisher={American Chemical
    Society (ACS)}, author={Rust, Tarik and Jung, Dimitri and Hoppe, Axel and Schoppa,
    Timo and Langer, Klaus and Kuckling, Dirk}, year={2021}, pages={3831–3842} }'
  chicago: 'Rust, Tarik, Dimitri Jung, Axel Hoppe, Timo Schoppa, Klaus Langer, and
    Dirk Kuckling. “Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery.”
    <i>ACS Applied Polymer Materials</i> 3, no. 8 (2021): 3831–42. <a href="https://doi.org/10.1021/acsapm.1c00411">https://doi.org/10.1021/acsapm.1c00411</a>.'
  ieee: 'T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, and D. Kuckling, “Backbone-Degradable
    (Co-)Polymers for Light-Triggered Drug Delivery,” <i>ACS Applied Polymer Materials</i>,
    vol. 3, no. 8, pp. 3831–3842, 2021, doi: <a href="https://doi.org/10.1021/acsapm.1c00411">10.1021/acsapm.1c00411</a>.'
  mla: Rust, Tarik, et al. “Backbone-Degradable (Co-)Polymers for Light-Triggered
    Drug Delivery.” <i>ACS Applied Polymer Materials</i>, vol. 3, no. 8, American
    Chemical Society (ACS), 2021, pp. 3831–42, doi:<a href="https://doi.org/10.1021/acsapm.1c00411">10.1021/acsapm.1c00411</a>.
  short: T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, D. Kuckling, ACS Applied
    Polymer Materials 3 (2021) 3831–3842.
date_created: 2025-04-22T06:02:11Z
date_updated: 2025-04-22T06:12:02Z
department:
- _id: '311'
doi: 10.1021/acsapm.1c00411
intvolume: '         3'
issue: '8'
keyword:
- backbone-degradable
- light-responsive
- redox-responsive
- drug delivery
- nanoparticles
language:
- iso: eng
main_file_link:
- url: https://pubs.acs.org/doi/10.1021/acsapm.1c00411?ref=PDF
page: 3831-3842
publication: ACS Applied Polymer Materials
publication_identifier:
  issn:
  - 2637-6105
  - 2637-6105
publication_status: published
publisher: American Chemical Society (ACS)
quality_controlled: '1'
status: public
title: Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery
type: journal_article
user_id: '62844'
volume: 3
year: '2021'
...