@article{60179, author = {{Weber, KS and Schlesinger, S and Goletzke, J and Straßburger, K and Zaharia, OP and Trenkamp, S and Wagner, R and Lieb, W and Buyken, Anette and Roden, M and Herder, C and group, GDS}}, issn = {{1475-2840}}, journal = {{Cardiovasc Diabetol}}, number = {{1}}, pages = {{53}}, title = {{{Associations of carbohydrate quality and cardiovascular risk factors vary among diabetes subtypes.}}}, volume = {{24}}, year = {{2025}}, } @article{60180, author = {{Kranz, RM and Kettler, C and Anand, C and Koeder, C and Husain, S and Schoch, N and Buyken, Anette and Englert, H}}, issn = {{0260-1060}}, journal = {{Nutr Health}}, number = {{1}}, pages = {{175--186}}, title = {{{Effect of a controlled lifestyle intervention on medication use and costs: The Healthy Lifestyle Community Program (cohort 2).}}}, volume = {{31}}, year = {{2025}}, } @article{60186, author = {{Lang, A and Schaefer, E and Kupriyanova, Y and Goletzke, J and Weber, KS and Buyken, Anette and Kahl, S and Zaharia, OP and Herder, C and Schrauwen-Hinderling, VB and Kuss, O and Wagner, R and Roden, M and Schlesinger, S and Diabetes Study Group, German}}, issn = {{1475-2891}}, journal = {{Nutr J}}, number = {{1}}, pages = {{74}}, title = {{{Cross-sectional association between the isocaloric replacement of carbohydrates with protein and fat in relation to fat compartments distribution and hepatic lipid content in recent-onset type 1 and type 2 diabetes.}}}, volume = {{24}}, year = {{2025}}, } @article{60182, author = {{Perrar, I and Hohoff, E and Lesani, A and Schmitting, S and Libuda, Lars and Krüger, Bettina and Stutz, Bianca and Nöthlings, U and Buyken, Anette and Alexy, U and Jankovic, N}}, issn = {{1436-6207}}, journal = {{Eur J Nutr}}, number = {{4}}, pages = {{165}}, title = {{{Circadian eating patterns track from infancy to pre- and primary school-age, but are not prospectively associated with body composition in childhood - Results of the DONALD cohort study.}}}, volume = {{64}}, year = {{2025}}, } @article{60184, author = {{Della Corte, KA and Bosler, T and McClure, C and Buyken, Anette and LeCheminant, JD and Schwingshackl, L and Della Corte, D}}, issn = {{2161-8313}}, journal = {{Adv Nutr}}, number = {{5}}, pages = {{100413}}, title = {{{Dietary Sugar Intake and Incident Type 2 Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.}}}, volume = {{16}}, year = {{2025}}, } @article{60187, author = {{Revheim, I and Sabir, Z and Dierkes, J and Buyken, Anette and Landberg, R and Alten, I and Spielau, U and Rosendahl-Riise, H}}, issn = {{1436-6207}}, journal = {{Eur J Nutr}}, number = {{5}}, pages = {{197}}, title = {{{Bread, wholegrain consumption and weight change from middle to late adulthood: a prospective cohort study. }}}, volume = {{64}}, year = {{2025}}, } @article{60181, author = {{Dannheim, I and Ludwig-Walz, H and Kirsch, H and Bujard, M and Buyken, Anette and Richardson, KM and Kroke, A}}, issn = {{0355-3140}}, journal = {{Scand J Work Environ Health}}, pages = {{4219}}, title = {{{Effectiveness of leader-targeted stress management interventions: A systematic review and meta-analysis.}}}, year = {{2025}}, } @article{60873, abstract = {{Abstract Variations in circadian rhythm-related genes influence the individual chronotype. Here, we hypothesize that the peak of clock gene expression at 7 a.m. differs between young adults with a late chronotype and young adults with an early chronotype. Participants of the Chronotype and Nutrition nutritional trial (ChroNu study) were selected for their chronotype assessed by the Munich Chronotype questionnaire (MCTQ) and actigraphy. Total RNA was isolated from CD14+ monocytes of participants at 7 a.m. on the run-in day. Expression levels of seven clock genes (PER1, PER2, PER3, NR1D1, NR1D2, CRY1 and CRISPLD2) of individuals with early (n = 11) or late chronotypes (n = 19) were analysed by reverse transcription quantitative polymerase chain reaction. Difference in expression levels was tested by Mann Whitney-U test. The relative expression levels of the selected genes were not significantly different between individuals with early and late chronotypes (all p > 0.07). Contrary to expectation, clock gene expression levels at 7 a.m. was similar in individuals with early and late chronotypes. Further studies on larger sample sizes with multiple sampling time points should elucidate whether gene expression is altered at other day times underscoring the biological difference between individuals with early or late chronotypes.}}, author = {{Krueger, Bettina and Rajcsanyi, Luisa Sophie and Hundertmark, Katharina and Stutz, Bianca and Hinney, Anke and Buyken, Anette E.}}, issn = {{2045-2322}}, journal = {{Scientific Reports}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Morning clock gene expression in young adults of early and late chronotypes}}}, doi = {{10.1038/s41598-025-12423-7}}, volume = {{15}}, year = {{2025}}, } @article{62899, abstract = {{Abstract Purpose This protocol outlines the rigorous process for developing the new German guideline on dietary carbohydrate intake and its impact on health-related outcomes, building on a substantial body of evidence regarding carbohydrate quantity and quality. Methods A professional guideline panel has been established, and research questions have been formulated a-priori. The novel methodological approach follows a structured process and adheres to established recommendations for guidelines. Results Umbrella reviews of systematic reviews with meta-analyses of randomized controlled trials or prospective observational studies on carbohydrate quantity and quality in relation to health-related outcomes will be conducted. Relevant aspects of carbohydrate intake include total carbohydrates, dietary sugars, starch, the dietary glycaemic index, the dietary insulin index, dietary glycaemic load, dietary insulin load, dietary fibre, and whole grains. The prioritized outcomes include body weight-related outcomes, type 2 diabetes, dyslipidemia, elevated blood pressure, cardiovascular diseases, cancer, and dental caries and periodontal diseases. The literature search will be conducted in MEDLINE and Epistemonikos starting from 2015, as older reports are likely covered or superseded by more recent ones. The most comprehensive systematic review with meta-analysis with the highest methodological quality standards (according to a modified version of AMSTAR 2) will be selected for each specific association or effect. The certainty of evidence will be rated using the GRADE approach. The guideline development will follow the Evidence-to-Decision (EtD) framework. Conclusions This methodological protocol is in line with international standards and provides transparent framework for the guideline on dietary carbohydrate intake and health-related outcomes of the Germany Nutrition Society. }}, author = {{Schlesinger, Sabrina and Conrad, Johanna and Amini, Anna Maria and Buyken, Anette and Egert, Sarah and Haardt, Julia and Kalotai, Nicole and Kroke, Anja and Schwingshackl, Lukas}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, number = {{5}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Dietary carbohydrate intake and health-related outcomes: a protocol for the evidence evaluation methodology for the new guideline on dietary carbohydrate intake of the German nutrition society}}}, doi = {{10.1007/s00394-025-03744-4}}, volume = {{64}}, year = {{2025}}, } @article{62898, abstract = {{Abstract Purpose This umbrella review aimed to investigate the evidence for an association of dietary intake of total protein as well as animal and plant protein with the incidence of coronary heart disease (CHD), stroke and total cardiovascular diseases (CVD). Methods PubMed, Embase and Cochrane Database were systematically searched for systematic reviews (SRs) of prospective studies with or without meta-analysis (MA) published between January 2012 and April 2024. Methodological quality, outcome-specific certainty of evidence, and overall certainty of evidence were assessed using established tools and predefined criteria. Results Ten SRs were considered eligible for the umbrella review; all were based on prospective cohort studies, and six conducted a MA. Dietary intakes of total, animal and plant protein were not associated with the risk of CHD or stroke. For CHD, the overall certainty of evidence for the absence of an association was “probable” for total, animal and plant protein. For stroke and total CVD, the overall certainty of evidence was rated as “possible” for the absence of an association with the intake of total protein and plant protein and insufficient for animal protein intake. Conclusion Given that most SRs on dietary protein intake did not indicate an association, it seems that protein intake plays no major role in the development of CVD. This investigation was registered at PROSPERO as CRD42018082395. }}, author = {{Egert, Sarah and Amini, Anna M. and Klug, Lea and Kalotai, Nicole and Haardt, Julia and Boeing, Heiner and Buyken, Anette and Kroke, Anja and Lorkowski, Stefan and Louis, Sandrine and Nimptsch, Katharina and Schulze, Matthias B. and Schwingshackl, Lukas and Siener, Roswitha and Stangl, Gabriele I. and Zittermann, Armin and Watzl, Bernhard and Ellinger, Sabine}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, number = {{6}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Protein intake and cardiovascular diseases: an umbrella review of systematic reviews for the evidence-based guideline on protein intake of the German Nutrition Society}}}, doi = {{10.1007/s00394-025-03746-2}}, volume = {{64}}, year = {{2025}}, } @article{62900, author = {{Hjorth, Therese and Schadow, Alena Marie and Revheim, Ingrid and Spielau, Ulrike and Meyer, Klara and Rieder, Anne and Varela, Paula and Ballance, Simon and Koerner, Antje and Landberg, Rikard and Buyken, Anette and Dierkes, Jutta and Rosendahl-Riise, Hanne}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, number = {{3}}, pages = {{724--732}}, publisher = {{Elsevier BV}}, title = {{{Effectiveness of regular oat β-glucan–enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial}}}, doi = {{10.1016/j.ajcnut.2025.06.018}}, volume = {{122}}, year = {{2025}}, } @article{50740, author = {{Weber, Katharina S. and Schlesinger, Sabrina and Lang, Alexander and Straßburger, Klaus and Maalmi, Haifa and Zhu, Anna and Zaharia, Oana-Patricia and Strom, Alexander and Bönhof, Gidon J. and Goletzke, Janina and Trenkamp, Sandra and Wagner, Robert and Buyken, Anette and Lieb, Wolfgang and Roden, Michael and Herder, Christian and Roden, M. and Al-Hasani, H. and Belgardt, B. and Lammert, E. and Bönhof, G. and Geerling, G. and Herder, C. and Icks, A. and Jandeleit-Dahm, K. and Kotzka, J. and Kuß, O. and Rathmann, W. and Schlesinger, S. and Schrauwen-Hinderling, V. and Szendroedi, J. and Trenkamp, S. and Wagner, R.}}, issn = {{0939-4753}}, journal = {{Nutrition, Metabolism and Cardiovascular Diseases}}, keywords = {{Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)}}, publisher = {{Elsevier BV}}, title = {{{Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes}}}, doi = {{10.1016/j.numecd.2023.12.026}}, year = {{2024}}, } @article{52712, author = {{Buyken, Anette and Libuda, Lars}}, journal = {{DGEwissen}}, title = {{{Ernährung und Alltagsbewältigung - Ein Spannungsfeld für Individuum, Haushalt und Gesellschaft}}}, year = {{2024}}, } @article{54422, abstract = {{Abstract Background The cereal fibre β-glucan reduces postprandial glycaemia, however, the underlying mechanisms are not fully understood. Thus, the aim of this study was to investigate the acute effect of a β-glucan-enriched oat bread on gastric emptying half-time (T1/2), gastric emptying lag phase (Tlag), and gastric emptying rate (GER), and the secretion of glucagon-like peptide-1 (GLP-1) as potential means to influence postprandial glycaemia. Methods A randomised crossover trial was conducted in 22 healthy adults (age 24.6 ± 3.1 years, BMI 23.1 ± 2.7 kg/m2) receiving 25 g available carbohydrates from a β-glucan-enriched oat bread or a control whole-wheat bread at two non-consecutive days. T1/2, Tlag, and GER were determined based on ultrasound measures of the cross-sectional gastric antrum area in the fasting state and 15, 30, 45, 60, 90, and 120 min postprandially. Capillary glucose, serum insulin, and plasma GLP-1 concentrations were measured at the same time points. Results A biphasic pattern of gastric emptying with a distinct Tlag before the commencement of emptying was observed in most subjects for both bread types. While no differences in GER were evident (p = 0.562), consumption of the oat bread significantly increased T1/2 by 18 min and Tlag by 14 min compared with the whole-wheat bread (p = 0.005 and p = 0.010, respectively). In addition, the oat bread significantly reduced iAUC2h for glucose and insulin responses compared with the whole-wheat bread (p = 0.001 and p < 0.001, respectively). There were no significant differences in GLP-1 response between the two breads (p = 0.892). Conclusion The increased T1/2 and Tlag could offer a potential mechanism for the observed attenuation of postprandial glycaemia and insulinemia after consumption of the β-glucan-enriched oat bread compared with the whole-wheat bread. Trial registration: The study is registered at clinicaltrails.gov (NCT04571866). }}, author = {{Revheim, Ingrid and Ballance, Simon and Standal, Adelheid Fretland and Rieder, Anne and Dierkes, Jutta and Buyken, Anette and Gilja, Odd Helge and Hausken, Trygve and Rosendahl-Riise, Hanne}}, issn = {{1743-7075}}, journal = {{Nutrition & Metabolism}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{The acute effect of a β-glucan-enriched oat bread on gastric emptying, GLP-1 response, and postprandial glycaemia and insulinemia: a randomised crossover trial in healthy adults}}}, doi = {{10.1186/s12986-024-00789-w}}, volume = {{21}}, year = {{2024}}, } @article{54424, abstract = {{Abstract Purpose It has been proposed that a higher habitual protein intake may increase cancer risk, possibly via upregulated insulin-like growth factor signalling. Since a systematic evaluation of human studies on protein intake and cancer risk based on a standardised assessment of systematic reviews (SRs) is lacking, we carried out an umbrella review of SRs on protein intake in relation to risks of different types of cancer. Methods Following a pre-specified protocol (PROSPERO: CRD42018082395), we retrieved SRs on protein intake and cancer risk published before January 22th 2024, and assessed the methodological quality and outcome-specific certainty of the evidence using a modified version of AMSTAR 2 and NutriGrade, respectively. The overall certainty of evidence was rated according to predefined criteria. Results Ten SRs were identified, of which eight included meta-analyses. Higher total protein intake was not associated with risks of breast, prostate, colorectal, ovarian, or pancreatic cancer incidence. The methodological quality of the included SRs ranged from critically low (kidney cancer), low (pancreatic, ovarian and prostate cancer) and moderate (breast and prostate cancer) to high (colorectal cancer). The outcome-specific certainty of the evidence underlying the reported findings on protein intake and cancer risk ranged from very low (pancreatic, ovarian and prostate cancer) to low (colorectal, ovarian, prostate, and breast cancer). Animal and plant protein intakes were not associated with cancer risks either at a low (breast and prostate cancer) or very low (pancreatic and prostate cancer) outcome-specific certainty of the evidence. Overall, the evidence for the lack of an association between protein intake and (i) colorectal cancer risk and (ii) breast cancer risk was rated as possible. By contrast, the evidence underlying the other reported results was rated as insufficient. Conclusion The present findings suggest that higher total protein intake may not be associated with the risk of colorectal and breast cancer, while conclusions on protein intake in relation to risks of other types of cancer are restricted due to insufficient evidence. }}, author = {{Kühn, Tilman and Kalotai, Nicole and Amini, Anna M. and Haardt, Julia and Lehmann, Andreas and Schmidt, Annemarie and Buyken, Anette and Egert, Sarah and Ellinger, Sabine and Kroke, Anja and Lorkowski, Stefan and Louis, Sandrine and Schulze, Matthias B. and Schwingshackl, Lukas and Siener, Roswitha and Stangl, Gabriele I. and Watzl, Bernhard and Zittermann, Armin and Nimptsch, Katharina}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society}}}, doi = {{10.1007/s00394-024-03380-4}}, year = {{2024}}, } @article{54421, abstract = {{Abstract Introduction This umbrella review aimed to investigate the evidence of an effect of dietary intake of total protein, animal and plant protein on blood pressure (BP), and hypertension (PROSPERO: CRD42018082395). Methods PubMed, Embase and Cochrane Database were systematically searched for systematic reviews (SRs) of prospective studies with or without meta-analysis published between 05/2007 and 10/2022. The methodological quality and outcome-specific certainty of evidence were assessed by the AMSTAR 2 and NutriGrade tools, followed by an assessment of the overall certainty of evidence. SRs investigating specific protein sources are described in this review, but not included in the assessment of the overall certainty of evidence. Results Sixteen SRs were considered eligible for the umbrella review. Ten of the SRs investigated total protein intake, six animal protein, six plant protein and four animal vs. plant protein. The majority of the SRs reported no associations or effects of total, animal and plant protein on BP (all “possible” evidence), whereby the uncertainty regarding the effects on BP was particularly high for plant protein. Two SRs addressing milk-derived protein showed a reduction in BP; in contrast, SRs investigating soy protein found no effect on BP. The outcome-specific certainty of evidence of the SRs was mostly rated as low. Discussion/conclusion This umbrella review showed uncertainties whether there are any effects on BP from the intake of total protein, or animal or plant proteins, specifically. Based on data from two SRs with milk protein, it cannot be excluded that certain types of protein could favourably influence BP. }}, author = {{Boeing, Heiner and Amini, Anna M. and Haardt, Julia and Schmidt, Annemarie and Bischoff-Ferrari, Heike A. and Buyken, Anette and Egert, Sarah and Ellinger, Sabine and Kroke, Anja and Lorkowski, Stefan and Louis, Sandrine and Nimptsch, Katharina and Schulze, Matthias B. and Schutkowski, Alexandra and Schwingshackl, Lukas and Siener, Roswitha and Zittermann, Armin and Watzl, Bernhard and Stangl, Gabriele I.}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence}}}, doi = {{10.1007/s00394-024-03336-8}}, year = {{2024}}, } @article{54423, abstract = {{Abstract Purpose Glycemic response to the same meal depends on daytime and alignment of consumption with the inner clock, which has not been examined by individual chronotype yet. This study examined whether the 2-h postprandial and 24-h glycemic response to a meal with high glycemic index (GI) differ when consumed early or late in the day among students with early or late chronotype. Methods From a screening of 327 students aged 18–25 years, those with early (n = 22) or late (n = 23) chronotype participated in a 7-day randomized controlled cross-over intervention study. After a 3-day observational phase, standardized meals were provided on run-in/washout (days 4 and 6) and intervention (days 5 and 7), on which participants received a high GI meal (GI = 72) in the morning (7 a.m.) or in the evening (8 p.m.). All other meals had a medium GI. Continuous glucose monitoring was used to measure 2-h postprandial and 24-h glycemic responses and their variability. Results Among students with early chronotype 2-h postprandial glucose responses to the high GI meal were higher in the evening than in the morning (iAUC: 234 (± 92) vs. 195 (± 91) (mmol/L) × min, p = 0.042). Likewise, mean and lowest 2-h postprandial glucose values were higher when the high GI meal was consumed in the evening (p < 0.001; p = 0.017). 24-h glycemic responses were similar irrespective of meal time. Participants with late chronotype consuming a high GI meal in the morning or evening showed similar 2-h postprandial (iAUC: 211 (± 110) vs. 207 (± 95) (mmol/L) × min, p = 0.9) and 24-h glycemic responses at both daytimes. Conclusions Diurnal differences in response to a high GI meal are confined to those young adults with early chronotype, whilst those with a late chronotype seem vulnerable to both very early and late high GI meals. Registered at clinicaltrials.gov (NCT04298645; 22/01/2020). }}, author = {{Stutz, Bianca and Krueger, Bettina and Goletzke, Janina and Jankovic, Nicole and Alexy, Ute and Herder, Christian and Dierkes, Jutta and Berg-Beckhoff, Gabriele and Jakobsmeyer, Rasmus and Reinsberger, Claus and Buyken, Anette}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Glycemic response to meals with a high glycemic index differs between morning and evening: a randomized cross-over controlled trial among students with early or late chronotype}}}, doi = {{10.1007/s00394-024-03372-4}}, year = {{2024}}, } @article{54420, author = {{Merz, Benedikt and Temme, Elisabeth and Alexiou, Hélène and Beulens, Joline Wilhelma Johanna and Buyken, Anette and Bohn, Torsten and Ducrot, Pauline and Falquet, Marie-Noëlle and Solano, Marta García and Haidar, Hanna and Infanger, Esther and Kühnelt, Charlotte and Rodríguez-Artalejo, Fernando and Sarda, Barthélémy and Steenbergen, Elly and Vandevijvere, Stefanie and Julia, Chantal}}, issn = {{2662-1355}}, journal = {{Nature Food}}, number = {{2}}, pages = {{102--110}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Nutri-Score 2023 update}}}, doi = {{10.1038/s43016-024-00920-3}}, volume = {{5}}, year = {{2024}}, } @article{54926, author = {{Stutz, Bianca and Krueger, Bettina and Goletzke, Janina and Jankovic, Nicole and Alexy, Ute and Herder, Christian and Dierkes, Jutta and Berg-Beckhoff, Gabriele and Jakobsmeyer, Rasmus and Reinsberger, Claus and Buyken, Anette E.}}, issn = {{1436-6215}}, journal = {{European Journal of Nutrition}}, publisher = {{Springer}}, title = {{{Glycemic response to meals with a high glycemic index differs between morning and evening: a randomized cross-over controlled trial among students with early or late chronotype}}}, doi = {{10.1007/s00394-024-03372-4}}, year = {{2024}}, } @article{54927, author = {{Stutz, Bianca and Goletzke, Janina and Krueger, Bettina and Jankovic, Nicole and Alexy, Ute and Herder, Christian and Jakobsmeyer, Rasmus and Reinsberger, Claus and Buyken, Anette E.}}, journal = {{Appetite}}, pages = {{107569}}, publisher = {{Elsevier}}, title = {{{Association between glucose dips and the feeling of hunger in a dietary intervention study among students with early and late chronotype-secondary analysis of a randomized cross-over nutrition trial}}}, doi = {{10.1016/j.appet.2024.107569}}, volume = {{200}}, year = {{2024}}, }