@article{27575,
abstract = {{There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II > 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score > 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with <19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.}},
author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}},
issn = {{1664-0640}},
journal = {{Frontiers in Psychiatry}},
title = {{{Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity}}},
doi = {{10.3389/fpsyt.2021.732759}},
year = {{2021}},
}
@article{27571,
abstract = {{(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.}},
author = {{Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and Wessing, Ida and Seitz, Jochen and Herpertz-Dahlmann, Beate and Hebebrand, Johannes and Libuda, Lars}},
issn = {{2072-6643}},
journal = {{Nutrients}},
title = {{{Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}}},
doi = {{10.3390/nu13072356}},
year = {{2021}},
}
@article{26525,
author = {{Hebebrand, Johannes and Antel, Jochen and Tan, Susanne and Wabitsch, Martin and Wiesing, Urban and Barth, Nikolaus and Ludwig, Christine and Bühlmeier, Judith and Libuda, Lars and Milos, Gabriella and Hinney, Anke}},
issn = {{1422-4917}},
journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}},
pages = {{1--5}},
title = {{{Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten}}},
doi = {{10.1024/1422-4917/a000775}},
year = {{2021}},
}
@article{35303,
abstract = {{Abstract
Purpose
Studies about effects of lunch dietary Glycemic Index (GI) on cognition of schoolchildren are scarce. Our previous CogniDo GI study found no changes of cognition in the early postprandial phase after consumption of two rice types with medium vs. high dietary GI for lunch (i.e., 45 min after starting lunch). This study investigated whether the dietary GI of lunch has an impact on cognition of schoolchildren in the late postprandial phase, 90 min after lunch.
Methods
A randomized, 2 × 2 crossover intervention study was conducted at a comprehensive school with 5th and 6th grade students. Participants (n = 212) were randomly assigned to either sequence 1 or 2. In the first period, participants of sequence 1 received a dish with high GI rice (GI: 79), those of sequence 2 with medium GI rice (GI: 64)—in the second period, 1 week later, vice versa. Computer-based cognitive testing was performed 90 min after lunch examining tonic alertness, visual search and task switching, and working memory. Treatment effects and treatment effects adjusted for estimated lunch glycemic load (GL) were analyzed using a linear mixed model.
Results
The selected cognitive parameters were not affected by the GI of lunch 90 min after lunch, neither after intention-to-treat nor in the per-protocol analysis. Adjustment for GL also did not change results.
Conclusion
The present study revealed no notable differences after the consumption of two rice types with medium vs. high dietary GI for lunch in children’s cognitive function in the late postprandial phase, 90 min after lunch.
Clinical trial registration
German Clinical Trials Register (DRKS00013597); date of registration: 16/04/2018, retrospectively registered.
}},
author = {{Drozdowska, Alina and Sinningen, Kathrin and Falkenstein, Michael and Rudolf, Henrik and Libuda, Lars and Buyken, Anette and Lücke, Thomas and Kersting, Mathilde}},
issn = {{1436-6207}},
journal = {{European Journal of Nutrition}},
keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}},
number = {{3}},
pages = {{1637--1647}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Impact of lunch with carbohydrates differing in glycemic index on children's cognitive functioning in the late postprandial phase: a randomized crossover study}}},
doi = {{10.1007/s00394-021-02766-y}},
volume = {{61}},
year = {{2021}},
}
@article{33986,
abstract = {{ Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. }},
author = {{Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}},
issn = {{1422-4917}},
journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}},
keywords = {{Psychiatry and Mental health, Clinical Psychology, General Medicine, Pediatrics, Perinatology and Child Health}},
number = {{3}},
pages = {{175--185}},
publisher = {{Hogrefe Publishing Group}},
title = {{{Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts}}},
doi = {{10.1024/1422-4917/a000829}},
volume = {{50}},
year = {{2021}},
}
@article{46078,
abstract = {{Abstract
Aim
To identify and summarize the evidence for the effect of health-oriented leadership interventions on health and well-being outcomes at the employee level following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (Moher et al. 2009).
Subject and Methods
A systematic search of relevant studies was conducted in multiple databases. Randomized controlled trials (RCTs), cluster-randomized controlled trials (cRCTs) and controlled before–after studies (CBAs) were included based on the following criteria: interventions that addressed supervisors, to raise awareness for the importance of health issues, teach mindfulness practices for conscious awareness, reduce stress and promote resources at the level of individual behavior, and evaluated the effect on at least one outcome of psychomental stress, absenteeism and well-being on the employee level.
Results
Of 6126 publications retrieved, ten studies were identified for analysis. Significant effects of leadership training were reported on exhaustion tendency, self-reported sickness absence, work-related sickness absence and job satisfaction in studies comparing health-oriented training programs to no intervention. Studies comparing health-oriented leadership training to other training did not report significant effects. Risk of bias was judged to be high in seven studies and unclear in three studies.
Conclusion
Evidence for the effectiveness of health-oriented leadership interventions on employees’ stress, absenteeism or well-being is judged to be low, clearly indicating the need for more and higher-quality research.
}},
author = {{Dannheim, Indra and Ludwig-Walz, Helena and Buyken, Anette and Grimm, Valerie and Kroke, Anja}},
issn = {{2198-1833}},
journal = {{Journal of Public Health}},
keywords = {{Public Health, Environmental and Occupational Health}},
number = {{12}},
pages = {{2777--2789}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Effectiveness of health-oriented leadership interventions for improving health and wellbeing of employees: a systematic review}}},
doi = {{10.1007/s10389-021-01664-1}},
volume = {{30}},
year = {{2021}},
}
@article{28011,
author = {{Brand-Miller, Jennie and Buyken, Anette}},
issn = {{1078-8956}},
journal = {{Nature Medicine}},
pages = {{828--830}},
title = {{{Mapping postprandial responses sets the scene for targeted dietary advice}}},
doi = {{10.1038/s41591-020-0909-1}},
year = {{2020}},
}
@article{26526,
author = {{Gappa, Monika and Filipiak‐Pittroff, Birgit and Libuda, Lars and Berg, Andrea and Koletzko, Sibylle and Bauer, Carl‐Peter and Heinrich, Joachim and Schikowski, Tamara and Berdel, Dietrich and Standl, Marie}},
issn = {{0105-4538}},
journal = {{Allergy}},
pages = {{1903--1907}},
title = {{{Long‐term effects of hydrolyzed formulae on atopic diseases in the GINI study}}},
doi = {{10.1111/all.14709}},
year = {{2020}},
}
@article{26527,
abstract = {{Abstract
Background
While observational studies revealed an inverse association between serum 25(OH)vitamin D (25(OH)D) and the risk of attention deficit/hyperactivity disorder (ADHD), the causality of this relationship remains unclear.
Methods
We conducted a bidirectional two-sample Mendelian Randomization (MR) study to examine whether 25(OH)D has an effect on the risk to develop ADHD or vice versa. Information on single nucleotide polymorphisms (SNP) associated with serum 25(OH)D was obtained from a genome-wide association study (GWAS) considering phenotype data from 79,366 individuals of European ancestry. Data on risk for ADHD were derived from a GWAS analysis with 20,183 individuals diagnosed with ADHD and 35,191 controls. For our analysis, we considered effect sizes based on the European participants (19,099 cases and 34,194 controls).
Results
Single SNP analyses showed a causal effect of vitamin D on ADHD risk for only one SNP (rs12785878, p = 0.024). The overall MR estimates did not reveal a causal effect of 25(OH)D on risk for ADHD. In the reverse analysis, neither any single nor the multi-SNP MR analyses showed a causal effect of ADHD on 25(OH)D.
Conclusion
Results from this two-sample MR study did not confirm a causal effect of 25(OH)D on ADHD or vice versa. Accordingly, our study does not provide evidence that improving 25(OH)D via supplementation could reduce the risk of developing ADHD.
}},
author = {{Libuda, Lars and Naaresh, Roaa and Ludwig, Christine and Laabs, Björn-Hergen and Antel, Jochen and Föcker, Manuel and Hebebrand, Johannes and Hinney, Anke and Peters, Triinu}},
issn = {{1436-6207}},
journal = {{European Journal of Nutrition}},
pages = {{2581--2591}},
title = {{{A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder}}},
doi = {{10.1007/s00394-020-02439-2}},
year = {{2020}},
}
@article{26529,
abstract = {{Abstract
Purpose
The influences of nutrition in childhood on puberty onset could have sustained consequences for health and wellbeing later in life. The aim of this study was to investigate the prospective association of diet quality prior to puberty with the timing of puberty onset.
Methods
We considered data from 3983 SCCNG (Southwest China Childhood Nutrition and Growth) study participants with dietary data, anthropometric measurement, and information on potential confounders at their baseline assessment (mean age: 7.1 years for girls and 7.3 years for boys; mean length of follow-up was 4.2 years). Cox proportional hazard regression estimating hazard ratios (HRs) and 95% confidence intervals (CIs) were used to examine the relationship between diet quality and puberty onset. Dietary intake at baseline was assessed using a validated food frequency questionnaire. Diet quality was determined using the Chinese Children Dietary Index (CCDI) which measures adherence to current dietary recommendations (theoretical range: 0–160 points). Age at Tanner stage 2 for breast/genital development (B2/G2), menarche or voice break (M/VB) were used as pubertal markers.
Results
The CCDI score ranged from 56.2 to 136.3 for girls and 46.1–131.5 for boys. Pubertal markers consistently indicate that girls and boys with higher diet quality were more likely to enter their puberty later than their counterparts with lower CCDI scores (higher vs. lower CCDI tertiles: adjusted HR for age at B2: 0.85 (95% CI, 0.81–0.94), p for trend = 0.02; G2: 0.86 (95% CI,0.80–0.96), p for trend = 0.02; M: 0.86 (95% CI,0.80–0.95), p for trend = 0.02; VB: 0.86 (95% CI,0.79–0.98), p for trend = 0.03), after adjustment for paternal education level, baseline energy intake, and pre-pubertal body fat.
Conclusions
Our data suggested a later puberty onset and later timing of progressed puberty stages in children with a high diet quality, which were independent of pre-pubertal body fat.
}},
author = {{Duan, Ruonan and Qiao, Tian and Chen, Yue and Chen, Mengxue and Xue, Hongmei and Zhou, Xue and Yang, Mingzhe and Liu, Yan and Zhao, Li and Libuda, Lars and Cheng, Guo}},
issn = {{1436-6207}},
journal = {{European Journal of Nutrition}},
pages = {{2423--2434}},
title = {{{The overall diet quality in childhood is prospectively associated with the timing of puberty}}},
doi = {{10.1007/s00394-020-02425-8}},
year = {{2020}},
}
@book{26872,
author = {{Klünder, Nina}},
pages = {{135}},
publisher = {{Beltz Juventa}},
title = {{{Die Ernährungsversorgung in Familien zwischen Zeit, Alltag und Haushaltsführung. Eine Mixed-Methods-Untersuchung}}},
year = {{2020}},
}
@techreport{26886,
author = {{Müller, Heinz and Klünder, Nina}},
pages = {{74}},
title = {{{Der Jugendamts-Monitor. Aufgaben – Trends – Daten}}},
year = {{2020}},
}
@article{27013,
abstract = {{AbstractFlavonoids are suggested to reduce disease risk. Since dietary habits are acquired during early life, describing age and time trends of flavonoid intake and major food sources are important for monitoring and disease prevention in later life. We aimed to describe total flavonoid intake and food sources and to investigate age and time trends of flavonoid intake in 3–18-year-olds, from the Dortmund Nutritional and Anthropometric Longitudinally Designed study from 1985 to 2016. Intake was assessed annually using 3-d weighed food records (WFR). Flavonoid values were assigned using the United States Department of Agriculture database. Foods contributing to intake were determined. Age and time trends in total flavonoid and isoflavone density were analysed by sex with PROC MIXED. In total, 1312 children completed 10 758 WFR. Across all ages, daily mean total flavonoid density was lower in boys compared with girls (134 v. 146 mg/4184 kJ) and no difference in median isoflavone density (0·04 mg/4184 kJ per d) was found. The top five foods contributing to total flavonoid intake were apple with peel (15·0/17·1 %), strawberries (5·9/6·1 %), chocolate spread (3·9/3·5 %), orange juice (3·5/3·4 %) and pasta (3·5/3·4 %) for boys and girls, respectively. Overall, in boys, total flavonoid density decreased over the course of age and time. In girls, there was no association with age or time. In both sexes, isoflavone density followed a U-shaped age trend with no change over time. From a public health perspective, the overall observed downwards trend of flavonoid intake in boys deserves attention. Future initiatives should be tailored at maintaining a high flavonoid density as children age, specifically among boys.}},
author = {{Rienks, Johanna and Penczynski, Katharina J. and Schmitting, Sarah and Buyken, Anette and Nöthlings, Ute}},
issn = {{0007-1145}},
journal = {{British Journal of Nutrition}},
pages = {{1198--1206}},
title = {{{Dietary flavonoids among children and adolescents in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study: intake, food sources and trends from 1985 until 2016}}},
doi = {{10.1017/s000711452000183x}},
year = {{2020}},
}
@article{27019,
abstract = {{AbstractTo examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.}},
author = {{Milos, Gabriella and Antel, Jochen and Kaufmann, Lisa-Katrin and Barth, Nikolaus and Koller, Antonia and Tan, Susanne and Wiesing, Urban and Hinney, Anke and Libuda, Lars and Wabitsch, Martin and von Känel, Roland and Hebebrand, Johannes}},
issn = {{2158-3188}},
journal = {{Translational Psychiatry}},
title = {{{Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects}}},
doi = {{10.1038/s41398-020-00977-1}},
year = {{2020}},
}
@article{27020,
author = {{Peters, Triinu and Nüllig, Lena and Antel, Jochen and Naaresh, Roaa and Laabs, Björn-Hergen and Tegeler, Lisa and Amhaouach, Chaima and Libuda, Lars and Hinney, Anke and Hebebrand, Johannes}},
issn = {{1664-8021}},
journal = {{Frontiers in Genetics}},
title = {{{The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study}}},
doi = {{10.3389/fgene.2020.00373}},
year = {{2020}},
}
@article{27795,
author = {{Kupriyanova, Yuliya and Zaharia, Oana Patricia and Bobrov, Pavel and Karusheva, Yanislava and Burkart, Volker and Szendroedi, Julia and Hwang, Jong-Hee and Roden, Michael and Roden, M. and Al-Hasani, H. and Burkart, V. and Buyken, Anette and Geerling, G. and Hwang, J.H. and Herder, C. and Icks, A. and Jandeleit-Dahm, K. and Kahl, S. and Kotzka, J. and Kuss, O. and Lammert, E. and Trenkamp, S. and Rathmann, W. and Szendroedi, J. and Ziegler, D.}},
issn = {{0168-8278}},
journal = {{Journal of Hepatology}},
pages = {{1028--1037}},
title = {{{Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus}}},
doi = {{10.1016/j.jhep.2020.11.030}},
year = {{2020}},
}
@article{27797,
abstract = {{Abstract
Objective
To provide a systematic overview of world dietary sugar and sugar-sweetened beverage (SSB) intake trends in children and adolescents.
Data Sources
Medline, Embase, and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched through January 2019 to identify longitudinal follow-up studies with time-trend data and repeated cross-sectional studies.
Data Extraction
Data from studies reporting ≥ 2 measurements (sugars, SSB, or sweets/candy) over ≥ 2 years and included ≥ 20 healthy, normal- or overweight children or adolescents aged 1–19 years.
Data Analysis
Data from 43 articles (n = 4 prospective cohort studies; n = 39 repeated cross-sectional studies) from 15 countries (n = 8 European countries plus Australia, Canada, China, South Korea, Mexico, Russia, and the United States) are presented narratively. According to the risk of bias in nonrandomized studies of interventions tool, 34 studies were judged to have a moderate risk of bias, and 5 to have a serious risk of bias.
Conclusions
Consumption among US children and adolescents increased substantially in the decades preceding 2000, followed by a faster and continued decline. As a whole, other international intake trends did not reveal drastic increases and decreases in SSB and dietary sugars; they tended to change only slightly across 3 decades.
}},
author = {{Della Corte, Karen and Fife, Jessica and Gardner, Alexis and Murphy, Britta L and Kleis, Linda and Della Corte, Dennis and Schwingshackl, Lukas and LeCheminant, James D and Buyken, Anette}},
issn = {{0029-6643}},
journal = {{Nutrition Reviews}},
pages = {{274--288}},
title = {{{World trends in sugar-sweetened beverage and dietary sugar intakes in children and adolescents: a systematic review}}},
doi = {{10.1093/nutrit/nuaa070}},
year = {{2020}},
}
@article{27799,
abstract = {{Dietary fibre is a generic term describing non-absorbed plant carbohydrates and small amounts of associated non-carbohydrate components. The main contributors of fibre to the diet are the cell walls of plant tissues, which are supramolecular polymer networks containing variable proportions of cellulose, hemicelluloses, pectic substances, and non-carbohydrate components, such as lignin. Other contributors of fibre are the intracellular storage oligosaccharides, such as fructans. A distinction needs to be made between intrinsic sources of dietary fibre and purified forms of fibre, given that the three-dimensional matrix of the plant cell wall confers benefits beyond fibre isolates. Movement through the digestive tract modifies the cell wall structure and may affect the interactions with the colonic microbes (e.g., small intestinally non-absorbed carbohydrates are broken down by bacteria to short-chain fatty acids, absorbed by colonocytes). These aspects, combined with the fibre associated components (e.g., micronutrients, polyphenols, phytosterols, and phytoestrogens), may contribute to the health outcomes seen with the consumption of dietary fibre. Therefore, where possible, processing should minimise the degradation of the plant cell wall structures to preserve some of its benefits. Food labelling should include dietary fibre values and distinguish between intrinsic and added fibre. Labelling may also help achieve the recommended intake of 14 g/1000 kcal/day.}},
author = {{Augustin, Livia S. A. and Aas, Anne-Marie and Astrup, Arnie and Atkinson, Fiona S. and Baer-Sinnott, Sara and Barclay, Alan W. and Brand-Miller, Jennie C. and Brighenti, Furio and Bullo, Monica and Buyken, Anette and Ceriello, Antonio and Ellis, Peter R. and Ha, Marie-Ann and Henry, Jeyakumar C. and Kendall, Cyril W. C. and La Vecchia, Carlo and Liu, Simin and Livesey, Geoffrey and Poli, Andrea and Salas-Salvadó, Jordi and Riccardi, Gabriele and Riserus, Ulf and Rizkalla, Salwa W. and Sievenpiper, John L. and Trichopoulou, Antonia and Usic, Kathy and Wolever, Thomas M. S. and Willett, Walter C. and Jenkins, David J. A.}},
issn = {{2072-6643}},
journal = {{Nutrients}},
title = {{{Dietary Fibre Consensus from the International Carbohydrate Quality Consortium (ICQC)}}},
doi = {{10.3390/nu12092553}},
year = {{2020}},
}
@article{27800,
abstract = {{ A lower 24-h urine pH (24h-pH), i.e., a higher renal excretion of free protons, at a given acid load to the body, denotes a reduction in the kidney’s capacity for net acid excretion (NAE). There is increasing evidence, not only for patients with type 2 diabetes but also for healthy individuals, that higher body fatness or waist circumference (WC) has a negative impact on renal function to excrete acids (NAE). We hypothesized that adiposity-related inflammation molecules might mediate this relation between adiposity and renal acid excretion function. Twelve biomarkers of inflammation were measured in fasting blood samples from 162 adult participants (18–25 yr old) of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had undergone anthropometric measurements and collected 24-h urine samples. Both Baron and Kenny’s (B&K’s) steps to test mediation and causal mediation analysis were conducted to examine the potential mediatory roles of biomarkers of inflammation in the WC-24-h pH relationship after strictly controlling for laboratory-measured NAE. In B&K’s mediation analysis, leptin, soluble intercellular adhesion molecule 1 (sICAM-1), and adiponectin significantly associated with the outcome 24-h pH and attenuated the WC-pH relation. In agreement herewith, causal mediation analysis estimated the “natural indirect effects” of WC on 24-h pH via leptin ( P = 0.01) and adiponectin ( P = 0.03) to be significant, with a trend for sICAM-1 ( P = 0.09). The calculated proportions mediated by leptin, adiponectin, and sICAM-1 were 64%, 23%, and 12%, respectively. Both mediation analyses identified an inflammatory cytokine (leptin) and an anti-inflammatory cytokine (adiponectin) along with sICAM-1 as being potentially involved in mediating adiposity-related influences on renal acid excretion capacity. }},
author = {{Hua, Yifan and Herder, Christian and Kalhoff, Hermann and Buyken, Anette and Esche, Jonas and Krupp, Danika and Wudy, Stefan A. and Remer, Thomas}},
issn = {{1931-857X}},
journal = {{American Journal of Physiology-Renal Physiology}},
pages = {{F469--F475}},
title = {{{Inflammatory mediators in the adipo-renal axis: leptin, adiponectin, and soluble ICAM-1}}},
doi = {{10.1152/ajprenal.00257.2020}},
year = {{2020}},
}
@article{27801,
author = {{Nyasordzi, Juliana and Penczynski, Katharina and Remer, Thomas and Buyken, Anette}},
issn = {{1932-6203}},
journal = {{PLOS ONE}},
title = {{{Early life factors and their relevance to intima-media thickness of the common carotid artery in early adulthood}}},
doi = {{10.1371/journal.pone.0233227}},
year = {{2020}},
}