@article{62087, abstract = {{AbstractHighlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch von Furanen zu Pyrrolen; mit Ammoniak zu primären Arylaminen; Metallschrott recyceln mit ionischen Flüssigkeiten; terminale Alkene mit Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente und Alkaloide.}}, author = {{Breugst, Martin and Andexer, Jennifer and Barra, Lena and Beil, Sebastian B. and Bierbach, Sascha and Burkhardt, Immo and Dumele, Oliver and Ernst, Martin and Frommer, Jennifer and Gellrich, Urs and Germer, Philipp and Giese, Michael and Huy, Peter and Klepp, Julian and Körber, Karsten and Kordes, Markus and Kuttruff, Christian A. and Lindel, Thomas and Pfrengle, Fabian and Pieber, Bartholomäus and Pietruszka, Jörg and Schaschke, Norbert and Senge, Mathias O. and Stadler, Nina and Storch, Golo and Teichert, Johannes F. and Waldvogel, Siegfried R. and Werner, Thomas and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{40--70}}, publisher = {{Wiley}}, title = {{{Trendbericht: Organische Chemie 2025}}}, doi = {{10.1002/nadc.20254147860}}, volume = {{73}}, year = {{2025}}, } @article{61335, abstract = {{Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus, efficient strategies for their preparation are in great demand. Herein, a novel protocol is reported for the synthesis of amidines based on PIII/PVO redox catalysis. This two‐step, one‐pot approach involves the activation of amides via PIII/PVO catalyzed in situ formation of imidoyl chloride intermediates which are directly converted upon reaction with amines into the corresponding amidines. Instead of traditionally used toxic and corrosive chloride sources, hexachloroacetone (HCA) is successfully employed as a halide source. The reaction proceeds with low catalyst loading (2 mol%) in BuOAc as the solvent. Under the optimized conditions, 20 amidines are prepared in yields up to 99%. A feasible mechanism is proposed based on experimental results. The synthetic potential of this method is evaluated in the preparation of the tyrosine kinase inhibitor (TKI) Erlotinib.}}, author = {{Medvaric, Viktorija and Paradies, Jan and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T2, T, CSSD}}, publisher = {{Wiley}}, title = {{{Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides}}}, doi = {{10.1002/adsc.70059}}, year = {{2025}}, } @article{62086, author = {{Stefanow, Vivian and Kell, Lukas and Leduskrasta, Aiga and Eh, Marcus and Panten, Johannes and Werner, Thomas}}, issn = {{0022-3263}}, journal = {{The Journal of Organic Chemistry}}, keywords = {{T4, CSSD}}, number = {{37}}, pages = {{12877--12887}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Straightforward Access to Terpene-Based 1,2-Diols and Their Acetals as Fragrance Ingredients}}}, doi = {{10.1021/acs.joc.5c00889}}, volume = {{90}}, year = {{2025}}, } @article{61336, author = {{Zhou, Rundong and Medvaric, Viktorija and Werner, Thomas and Paradies, Jan}}, issn = {{0002-7863}}, journal = {{Journal of the American Chemical Society}}, keywords = {{T2, CSSD}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Metal-Free Reduction of Nitrous Oxide via PIII/PV═O Cycling: Mechanistic Insights and Catalytic Performance}}}, doi = {{10.1021/jacs.5c06190}}, year = {{2025}}, } @article{62093, abstract = {{AbstractUnter anderem das hat die Organik im letzten Jahr bewegt: milde Oxidation mit Elektrochemie, Oxidation zu enantiomerenreinen Sulfonylverbindungen, Flüssigkristallphasen erkennen mit maschinellem Lernen, CO2reagiert zu Succinat und Carbamaten, eine Alternative zu Bisphenol A, Subporphyrine, photoschaltbare Spinmaterialien, photochemische Thiophen‐Ringerweiterung, und Peptide werden mit Bor versehen und cyclisiert. Die Zusammenstellung des Trendberichts koordiniert hat Martin Breugst, Universität Chemnitz.}}, author = {{Breugst, Martin and Andexer, Jennifer and Barra, Lena and Beil, Sebastian B. and Breinbauer, Rolf and Burkhardt, Immo and Dumele, Oliver and Ernst, Martin and Gellrich, Urs and Germer, Philipp and Giese, Michael and Huy, Peter and Kath‐Schorr, Stephanie and Klepp, Julian and Körber, Karsten and Kordes, Markus and Kuttruff, Christian A. and Lindel, Thomas and Myllek, Sebastian and Pfrengle, Fabian and Pietruszka, Jörg and Schaschke, Norbert and Senge, Mathias O. and Storch, Golo and Teichert, Johannes F. and Tönjes, Jan and Waldvogel, Siegfried R. and Werner, Thomas and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{44--67}}, publisher = {{Wiley}}, title = {{{Trendbericht Organische Chemie 2024}}}, doi = {{10.1002/nadc.20244139258}}, volume = {{72}}, year = {{2024}}, } @article{62092, author = {{Nyemeck, Suzanne L. and Eyong, Kenneth O. and Bidingha, Ronald and Kamdem, Michael HK. and Ndinteh, Derek T. and Odumosu, Patricia O. and Folefoc, Gabriel N. and Bilanda, Danielle C. and Egbe, Andrew E. and Werner, Thomas and Bekono, Boris D. and Ntie-Kang, Fidele}}, issn = {{1874-3900}}, journal = {{Phytochemistry Letters}}, keywords = {{T4}}, pages = {{59--67}}, publisher = {{Elsevier BV}}, title = {{{Design, isolation, synthesis, and mechanistic insight of flavonoids isolated from Beilschmiedia obscura, as potential α-glucosidase inhibitors}}}, doi = {{10.1016/j.phytol.2024.06.004}}, volume = {{62}}, year = {{2024}}, } @article{62090, abstract = {{The selective N-formylation and N-methylation of amines with carbon dioxide (CO2) catalyzed by methyltriphenylphosphonium methylcarbonate and tuned by polymethylhydrosiloxane or trimethoxysilane as reducing agents is reported.}}, author = {{Ren, Changyue and Terazzi, Constanza and Werner, Thomas}}, issn = {{1463-9262}}, journal = {{Green Chemistry}}, keywords = {{T1, T2, CSSD}}, number = {{1}}, pages = {{439--447}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Tuneable reduction of CO2 – organocatalyzed selective formylation and methylation of amines}}}, doi = {{10.1039/d3gc03993e}}, volume = {{26}}, year = {{2024}}, } @article{62091, author = {{Ren, Changyue and Spannenberg, Anke and Werner, Thomas}}, issn = {{2168-0485}}, journal = {{ACS Sustainable Chemistry & Engineering}}, keywords = {{T1, T2, CSSD}}, number = {{29}}, pages = {{10969--10977}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO2}}}, doi = {{10.1021/acssuschemeng.4c03464}}, volume = {{12}}, year = {{2024}}, } @article{62097, abstract = {{AbstractPolystyrolproben werden mit Eisen(III)chlorid und weißen LEDs zu Oligomeren und Benzoylprodukten; ein Wolframatkatalysator invertiert die Absolutkonfiguration an sp3‐Kohlenstoffzentren; gelöstes Rätsel um eine symmetrieverbotene konrotatorische 14‐Elektronen‐Elektrocyclisierung; Polycarbonate, die sich ohne Lösungsmittel recyceln lassen: Highlights von Oktober 2021 bis 2022.}}, author = {{Breugst, Martin and Andexer, Jennifer N. and Beil, Sebastian B. and Breinbauer, Rolf and Dumele, Oliver and Ernst, Martin and Gellrich, Urs and Germer, Philipp and Giese, Michael and Gulder, Tobias A. M. and Huy, Peter and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Körber, Karsten and Kordes, Markus and Kuttruff, Christian and Lindel, Thomas and Meier, Robin and Myllek, Sebastian and Schaschke, Norbert and Pfrengle, Fabian and Pietruszka, Jörg and Sebode, Hanna and Senge, Mathias O. and Storch, Golo and Straub, Bernd F. and Teichert, Johannes and Waldvogel, Siegfried R. and Werner, Thomas and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{40--66}}, publisher = {{Wiley}}, title = {{{Trendbericht Organische Chemie 2023}}}, doi = {{10.1002/nadc.20234135542}}, volume = {{71}}, year = {{2023}}, } @article{62094, author = {{Yemback, Pierre and Eyong, Kenneth O. and Efange, Noella M. and Kamdem, Michael HK. and Ndinteh, Derek T. and Odumosu, Patricia O. and Folefoc, Gabriel N. and Ayong, Lawrence and Werner, Thomas}}, issn = {{1874-3900}}, journal = {{Phytochemistry Letters}}, keywords = {{T4}}, pages = {{26--35}}, publisher = {{Elsevier BV}}, title = {{{Lupane derivatives: Design, isolation, synthesis and evaluation of antiplasmodial activity against Plasmodium falciparum 3D7 strain}}}, doi = {{10.1016/j.phytol.2023.06.009}}, volume = {{57}}, year = {{2023}}, } @article{62096, abstract = {{AbstractThe biocatalytic kinetic resolution of cyclic carbonates derived from glycerol is reported. A selection of 26 esterases and lipases was tested for the asymmetric hydrolysis of the model substrate (epichlorohydrin carbonate) in aqueous medium. Among them, Pig Liver Esterase and Novozym® 435 showed the best selectivity with E=38 and 49, respectively. Both enzymes were employed for the conversion of 12 glycerol derivatives under optimized conditions. The resolution of halogenated carbonates afforded the unconverted enantiomer in up to >99 : 1 er. Furthermore, Novozym® 435 was successfully recycled 10 times without significant loss of activity. Upscaling and isolation of the chiral carbonate was also demonstrated. Subsequent conversion of this chiral building block allowed the direct one‐pot synthesis of (S)‐Guaifenesin, (S)‐Mephenesin and (S)‐Chlorphenesin in up to 89 % yield and 94 : 6 er.}}, author = {{Terazzi, Constanza and Spannenberg, Anke and von Langermann, Jan and Werner, Thomas}}, issn = {{1867-3880}}, journal = {{ChemCatChem}}, keywords = {{T1, T4, CSSD}}, number = {{19}}, publisher = {{Wiley}}, title = {{{Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic Resolution of Glycerol‐Derived Cyclic Carbonates}}}, doi = {{10.1002/cctc.202300917}}, volume = {{15}}, year = {{2023}}, } @article{62095, author = {{Tönjes, Jan and Kell, Lukas and Werner, Thomas}}, issn = {{1523-7060}}, journal = {{Organic Letters}}, keywords = {{T2, CSSD}}, number = {{51}}, pages = {{9114--9118}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Organocatalytic Stereospecific Appel Reaction}}}, doi = {{10.1021/acs.orglett.3c03463}}, volume = {{25}}, year = {{2023}}, } @article{37942, author = {{Andexer, Jennifer N. and Beifuss, Uwe and Brasholz, Malte and Breinbauer, Rolf and Breugst, Martin and Dumele, Oliver and Ernst, Martin and Ganardi, Ruth and Giese, Michael and Gulder, Tobias A. M. and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Körber, Karsten and Kordes, Markus and Lindel, Thomas and Mück‐Lichtenfeld, Christian and Niemeyer, Jochen and Pfau, Roland and Pfrengle, Fabian and Pietruszka, Jörg and Röckl, Johannes L. and Schaschke, Norbert and Sebode, Hanna and Senge, Mathias O. and Straub, Bernd F. and Teichert, Johannes and Waldvogel, Siegfried R. and Werner, Thomas and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, keywords = {{General Chemical Engineering, General Chemistry}}, number = {{3}}, pages = {{42--69}}, publisher = {{Wiley}}, title = {{{Trendbericht Organische Chemie 2022}}}, doi = {{10.1002/nadc.20224122453}}, volume = {{70}}, year = {{2022}}, } @article{37938, author = {{Terazzi, Constanza and Laatz, Karoline and von Langermann, Jan and Werner, Thomas}}, issn = {{2168-0485}}, journal = {{ACS Sustainable Chemistry and Engineering}}, keywords = {{T1, T3, CSSD}}, number = {{40}}, pages = {{13335--13342}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Synthesis of Cyclic Carbonates Catalyzed by CaI2–Et3N and Studies on Their Biocatalytic Kinetic Resolution}}}, doi = {{10.1021/acssuschemeng.2c03210}}, volume = {{10}}, year = {{2022}}, } @article{37940, author = {{Ren, Changyue and Spannenberg, Anke and Werner, Thomas}}, issn = {{2193-5807}}, journal = {{Asian Journal of Organic Chemistry}}, keywords = {{T1, T2, CSSD}}, number = {{9}}, publisher = {{Wiley}}, title = {{{Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO 2}}}, doi = {{10.1002/ajoc.202200156}}, volume = {{11}}, year = {{2022}}, } @misc{62144, author = {{Weber, Arne and Werner, Thomas and Grandane, Aiga and Stefanow, V. and Lenz, O.}}, title = {{{Verfahren zur Herstellung von Cedrendiol}}}, year = {{2022}}, } @article{37947, author = {{Paradies, Jan and Andexer, Jennifer and Beifuss, Uwe and Beuerle, Florian and Brasholz, Malte and Breinbauer, Rolf and Ernst, Martin and Ganardi, Ruth and Gulder, Tobias A. M. and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Körber, Karsten and Kordes, Markus and Lehmann, Matthias and Lindel, Thomas and Luy, Burkhard and Mück‐Lichtenfeld, Christian and Muhle‐Goll, Claudia and Niemeyer, Jochen and Pfau, Roland and Pietruszka, Jörg and Röckl, Johannes L. and Schaschke, Norbert and Senge, Mathias O. and Straub, Bernd F. and Waldvogel, Siegfried R. and Werner, Thomas and Werz, Daniel B. and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, keywords = {{General Chemical Engineering, General Chemistry}}, number = {{3}}, pages = {{38--68}}, publisher = {{Wiley}}, title = {{{Organische Chemie}}}, doi = {{10.1002/nadc.20214105947}}, volume = {{69}}, year = {{2021}}, } @article{37950, author = {{Hu, Yuya and Wei, Zhihong and Frey, Anna and Kubis, Christoph and Ren, Chang‐Yue and Spannenberg, Anke and Jiao, Haijun and Werner, Thomas}}, issn = {{1864-5631}}, journal = {{ChemSusChem}}, keywords = {{T1}}, number = {{1}}, pages = {{363--372}}, publisher = {{Wiley}}, title = {{{Catalytic, Kinetic, and Mechanistic Insights into the Fixation of CO2 with Epoxides Catalyzed by Phenol‐Functionalized Phosphonium Salts}}}, doi = {{10.1002/cssc.202002267}}, volume = {{14}}, year = {{2021}}, } @article{37946, abstract = {{AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.}}, author = {{Werner, Thomas and Grandane, Aiga and Pudnika, Linda and Domraceva, Ilona and Zalubovskis, Raivis}}, issn = {{0039-7881}}, journal = {{Synthesis}}, keywords = {{T2, T4, CSSD}}, number = {{19}}, pages = {{3545--3554}}, publisher = {{Georg Thieme Verlag KG}}, title = {{{Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones}}}, doi = {{10.1055/a-1509-6078}}, volume = {{53}}, year = {{2021}}, } @article{37944, abstract = {{

A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.

}}, author = {{Liu, Xin and Werner, Thomas}}, issn = {{2041-6520}}, journal = {{Chemical Science}}, keywords = {{T1, T3, CSSD}}, number = {{31}}, pages = {{10590--10597}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes}}}, doi = {{10.1039/d1sc02663a}}, volume = {{12}}, year = {{2021}}, }