@article{27575, abstract = {{There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II &gt; 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score &gt; 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with &lt;19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.}}, author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{1664-0640}}, journal = {{Frontiers in Psychiatry}}, title = {{{Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity}}}, doi = {{10.3389/fpsyt.2021.732759}}, year = {{2021}}, } @article{27571, abstract = {{(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.}}, author = {{Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and Wessing, Ida and Seitz, Jochen and Herpertz-Dahlmann, Beate and Hebebrand, Johannes and Libuda, Lars}}, issn = {{2072-6643}}, journal = {{Nutrients}}, title = {{{Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}}}, doi = {{10.3390/nu13072356}}, year = {{2021}}, } @article{26632, abstract = {{AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.}}, author = {{Freff, Jana and Schwarte, Kathrin and Bröker, Lisa and Bühlmeier, Judith and Kraft, Isabelle and Öztürk, Dana and Hinney, Anke and Arolt, Volker and Dannlowski, Udo and Romer, Georg and Baune, Bernhard T. and Hebebrand, Johannes and Föcker, Manuel and Alferink, Judith}}, issn = {{2045-2322}}, journal = {{Scientific Reports}}, title = {{{Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa}}}, doi = {{10.1038/s41598-020-80693-4}}, year = {{2021}}, } @article{26525, author = {{Hebebrand, Johannes and Antel, Jochen and Tan, Susanne and Wabitsch, Martin and Wiesing, Urban and Barth, Nikolaus and Ludwig, Christine and Bühlmeier, Judith and Libuda, Lars and Milos, Gabriella and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, pages = {{1--5}}, title = {{{Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten}}}, doi = {{10.1024/1422-4917/a000775}}, year = {{2021}}, } @article{35303, abstract = {{Abstract Purpose Studies about effects of lunch dietary Glycemic Index (GI) on cognition of schoolchildren are scarce. Our previous CogniDo GI study found no changes of cognition in the early postprandial phase after consumption of two rice types with medium vs. high dietary GI for lunch (i.e., 45 min after starting lunch). This study investigated whether the dietary GI of lunch has an impact on cognition of schoolchildren in the late postprandial phase, 90 min after lunch. Methods A randomized, 2 × 2 crossover intervention study was conducted at a comprehensive school with 5th and 6th grade students. Participants (n = 212) were randomly assigned to either sequence 1 or 2. In the first period, participants of sequence 1 received a dish with high GI rice (GI: 79), those of sequence 2 with medium GI rice (GI: 64)—in the second period, 1 week later, vice versa. Computer-based cognitive testing was performed 90 min after lunch examining tonic alertness, visual search and task switching, and working memory. Treatment effects and treatment effects adjusted for estimated lunch glycemic load (GL) were analyzed using a linear mixed model. Results The selected cognitive parameters were not affected by the GI of lunch 90 min after lunch, neither after intention-to-treat nor in the per-protocol analysis. Adjustment for GL also did not change results. Conclusion The present study revealed no notable differences after the consumption of two rice types with medium vs. high dietary GI for lunch in children’s cognitive function in the late postprandial phase, 90 min after lunch. Clinical trial registration German Clinical Trials Register (DRKS00013597); date of registration: 16/04/2018, retrospectively registered. }}, author = {{Drozdowska, Alina and Sinningen, Kathrin and Falkenstein, Michael and Rudolf, Henrik and Libuda, Lars and Buyken, Anette and Lücke, Thomas and Kersting, Mathilde}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}}, number = {{3}}, pages = {{1637--1647}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Impact of lunch with carbohydrates differing in glycemic index on children's cognitive functioning in the late postprandial phase: a randomized crossover study}}}, doi = {{10.1007/s00394-021-02766-y}}, volume = {{61}}, year = {{2021}}, } @article{48035, abstract = {{BACKGROUND: Previous studies suggest better visual-spatial processing when participants are tested in postures in which dynamic stability is challenged. The question arises if this is also true for the performance in mental body-rotation tasks (MBRT). AIM: Taking the embodied cognition approach into account, the first aim of the present study was to examine the potential influence of different demands on dynamic stability for two postures (parallel stand vs. tandem stand) on solving two versions of the MBRT, inducing either an object-based or an egocentric perspective transformation strategy. The second aim was to investigate if these different demands on dynamic stability are reflected in postural sway parameters. METHOD: Thirty participants (18 females and 12 males) were tested in the two MBRTs and in a control condition. All tasks were performed while standing on a balance beam in tandem stand and in a feet parallel position on a force plate. RESULTS: The results for response time and response error revealed effects of rotation angle and task, but no effect of posture. The analyzed Center of Pressure (CoP) data revealed a reduction of body sway during the MBRT for egocentric perspective transformations. CONCLUSION: The results indicate that participants performed better for egocentric than for object-based transformations and that the egocentric transformation leads to more postural stability than the object-based.}}, author = {{Budde, Kirsten and Jöllenbeck, Thomas and Barela, José A. and Figueiredo, Gabriella A. and Weigelt, Matthias}}, issn = {{2446-4902}}, journal = {{Brazilian Journal of Motor Behavior}}, number = {{3}}, pages = {{180--194}}, publisher = {{Brazilian Journal for Motor Behavior}}, title = {{{Mental body rotation with egocentric and object-based transformations in different postures: standing vs. balancing}}}, doi = {{10.20338/bjmb.v15i3.250}}, volume = {{15}}, year = {{2021}}, } @inproceedings{48037, author = {{Budde, Kirsten and Barela, José A and Figueiredo, Gabriella A and Weigelt, Matthias}}, booktitle = {{TeaP 2021 - Abstracts of the 63rd Conference of Experimental Psychologists.}}, editor = {{Huckauf, Anke and Baumann, Martin and Ernst, Marc and Herbert, Cornelia and Kiefer, Markus and Sauter, Marian}}, location = {{Ulm}}, pages = {{50}}, title = {{{Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing.}}}, doi = {{10.23668/PSYCHARCHIVES.5178}}, year = {{2021}}, } @article{46545, abstract = {{Context: Only 55% of the athletes return to competitive sports after an anterior cruciate ligament (ACL) injury. Athletes younger than 25 years who return to sports have a second injury rate of 23%. There may be a mismatch between rehabilitation contents and the demands an athlete faces after returning to sports. Current return-to-sports (RTS) tests utilize closed and predictable motor skills; however, demands on the field are different. Neurocognitive functions are essential to manage dynamic sport situations and may fluctuate after peripheral injuries. Most RTS and rehabilitation paradigms appear to lack this aspect, which might be linked to increased risk of second injury. Objective: This systematic and scoping review aims to map existing evidence about neurocognitive and neurophysiological functions in athletes, which could be linked to ACL injury in an integrated fashion and bring an extensive perspective to assessment and rehabilitation approaches. Data Sources: PubMed and Cochrane databases were searched to identify relevant studies published between 2005 and 2020 using the keywords ACL, brain, cortical, neuroplasticity, cognitive, cognition, neurocognition, and athletes. Study Selection: Studies investigating either neurocognitive or neurophysiological functions in athletes and linking these to ACL injury regardless of their design and technique were included. Study Design: Systematic review. Level of Evidence: Level 3. Data Extraction: The demographic, temporal, neurological, and behavioral data revealing possible injury-related aspects were extracted and summarized. Results: A total of 16 studies were included in this review. Deficits in different neurocognitive domains and changes in neurophysiological functions could be a predisposing risk factor for, or a consequence caused by, ACL injuries. Conclusion: Clinicians should view ACL injuries not only as a musculoskeletal but also as a neural lesion with neurocognitive and neurophysiological aspects. Rehabilitation and RTS paradigms should consider these changes for assessment and interventions after injury. }}, author = {{Piskin, Daghan Yuksel and Benjaminse, Anne and Dimitrakis, Panagiotis and Gokeler, Alli}}, issn = {{1941-7381}}, journal = {{Sports Health: A Multidisciplinary Approach}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, number = {{4}}, pages = {{549--555}}, publisher = {{SAGE Publications}}, title = {{{Neurocognitive and Neurophysiological Functions Related to ACL Injury: A Framework for Neurocognitive Approaches in Rehabilitation and Return-to-Sports Tests}}}, doi = {{10.1177/19417381211029265}}, volume = {{14}}, year = {{2021}}, } @article{28862, author = {{Grimminger-Seidensticker, Elke and Vieille Marchiset, G. and Knobé, S. and Aceti, M.}}, journal = {{SociologieS.}}, title = {{{Des arbitrages éthiques face aux injonctions à la pratique physique dans les programmes de promotion de la santé : le cas des familles populaires en Europe}}}, year = {{2021}}, } @inbook{35504, author = {{Grimminger-Seidensticker, Elke and Brandl-Bredenbeck, Hans Peter and Gerlach, Erin and Krieger, Claus}}, booktitle = {{Sportpädagogik. Eine Grundlegend}}, editor = {{Balz, Eckart and Reuker, Sabine and Scheid, Volker and Sygusch, Ralf}}, pages = {{151--153}}, publisher = {{Kohlhammer}}, title = {{{Zur Einführung in Kapitel 10 und 11}}}, year = {{2021}}, } @inbook{35502, author = {{Grimminger-Seidensticker, Elke and Krieger, Claus}}, booktitle = {{Sportpädagogik. Eine Grundlegung}}, editor = {{Balz, Eckart and Reuker, Sabine and Scheid, Volker and Sygusch, Ralf}}, pages = {{154--168}}, publisher = {{Kohlhammer}}, title = {{{Forschungsmethodische Zugänge}}}, year = {{2021}}, } @inproceedings{37843, author = {{Krause, Daniel and Behrens, J.B. and Löhers, L. and Weigelt, Matthias}}, title = {{{Mentale Rotationsleistungen bei der Betrachtung und Umsetzung von Spielzügen im Basketball: Novizen vs. erfahrene Basketballspieler}}}, year = {{2021}}, } @inproceedings{38080, author = {{Dahm, Stephan and Weigelt, Matthias and Rieger, M.}}, title = {{{Representations after mentally practiced one finger sequences are effector independent}}}, year = {{2021}}, } @inproceedings{38082, author = {{Budde, Kirsten and Barela, J.A. and Figueiredo, G.A. and Weigelt, Matthias}}, title = {{{Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing}}}, year = {{2021}}, } @article{37782, abstract = {{The present paper investigates factors contributing to the home advantage, by using the exceptional opportunity to study professional football matches played in the absence of spectators due to the COVID-19 pandemic in 2020. More than 40,000 matches before and during the pandemic, including more than 1,000 professional matches without spectators across the main European football leagues, have been analyzed. Results support the notion of a crowd-induced referee bias as the increased sanctioning of away teams disappears in the absence of spectators with regard to fouls (p < .001), yellow cards (p < .001), and red cards (p < .05). Moreover, the match dominance of home teams decreases significantly as indicated by shots (p < .001) and shots on target (p < .01). In terms of the home advantage itself, surprisingly, only a non-significant decrease is found. While the present paper supports prior research with regard to a crowd-induced referee bias, spectators thus do not seem to be the main driving factor of the home advantage. Results from amateur football, being naturally played in absence of a crowd, provide further evidence that the home advantage is predominantly caused by factors not directly or indirectly attributable to a noteworthy number of spectators.}}, author = {{Wunderlich, Fabian and Weigelt, Matthias and Rein, Robert and Memmert, Daniel}}, issn = {{1932-6203}}, journal = {{PLOS ONE}}, keywords = {{Multidisciplinary}}, number = {{3}}, publisher = {{Public Library of Science (PLoS)}}, title = {{{How does spectator presence affect football? Home advantage remains in European top-class football matches played without spectators during the COVID-19 pandemic}}}, doi = {{10.1371/journal.pone.0248590}}, volume = {{16}}, year = {{2021}}, } @article{37772, abstract = {{BACKGROUND: Previous studies suggest better visual-spatial processing when participants are tested in postures in which dynamic stability is challenged. The question arises if this is also true for the performance in mental body-rotation tasks (MBRT). AIM: Taking the embodied cognition approach into account, the first aim of the present study was to examine the potential influence of different demands on dynamic stability for two postures (parallel stand vs. tandem stand) on solving two versions of the MBRT, inducing either an object-based or an egocentric perspective transformation strategy. The second aim was to investigate if these different demands on dynamic stability are reflected in postural sway parameters. METHOD: Thirty participants (18 females and 12 males) were tested in the two MBRTs and in a control condition. All tasks were performed while standing on a balance beam in tandem stand and in a feet parallel position on a force plate. RESULTS: The results for response time and response error revealed effects of rotation angle and task, but no effect of posture. The analyzed Center of Pressure (CoP) data revealed a reduction of body sway during the MBRT for egocentric perspective transformations. CONCLUSION: The results indicate that participants performed better for egocentric than for object-based transformations and that the egocentric transformation leads to more postural stability than the object-based.}}, author = {{Budde, Kirsten and Jöllenbeck, Thomas and Barela, José A. and Figueiredo, Gabriella A. and Weigelt, Matthias}}, issn = {{2446-4902}}, journal = {{Brazilian Journal of Motor Behavior}}, keywords = {{General Engineering}}, number = {{3}}, pages = {{180--194}}, publisher = {{Brazilian Journal for Motor Behavior}}, title = {{{Mental body rotation with egocentric and object-based transformations in different postures: standing vs. balancing}}}, doi = {{10.20338/bjmb.v15i3.250}}, volume = {{15}}, year = {{2021}}, } @article{37778, author = {{Krause, Daniel and Richert, Benjamin and Weigelt, Matthias}}, issn = {{0953-816X}}, journal = {{European Journal of Neuroscience}}, keywords = {{General Neuroscience}}, number = {{4}}, pages = {{5384--5403}}, publisher = {{Wiley}}, title = {{{Neurophysiology of embodied mental rotation: Event‐related potentials in a mental rotation task with human bodies as compared to alphanumeric stimuli}}}, doi = {{10.1111/ejn.15383}}, volume = {{54}}, year = {{2021}}, } @article{40601, abstract = {{Abstract Background and aims One reason for the controversial discussion of whether the dual task (DT) walking paradigm has an added value for diagnosis in clinical conditions might be the use of different gait measurement systems. Therefore, the purpose was 1) to detect DT effects of central gait parameters obtained from five different gait analysis devices in young and old adults, 2) to assess the consistency of the measurement systems, and 3) to determine if the absolut and proportional DT costs (DTC) are greater than the system-measurement error under ST. Methods Twelve old (72.2 ± 7.9y) and 14 young adults (28.3 ± 6.2y) walked a 14.7-m distance under ST and DT at a self-selected gait velocity. Interrater reliability, precision of the measurement and sensitivity to change were calculated under ST and DT. Results An age effect was observed in almost all gait parameters for the ST condition. For DT only differences for stride length (p < .029, ɳ2p = .239) as well as single and double limb support (p = .036, ɳ2p = .227; p = .034, ɳ2p = .218) remained. The measurement systems showed a lower absolute agreement compared to consistency across all systems. Conclusions When reporting DT effects, the real changes in performance and random measurement errors should always be accounted for. These findings have strong implications for interpreting DT effects. }}, author = {{Klotzbier, Thomas Jürgen and Wollesen, Bettina and Vogel, Oliver and Rudisch, Julian and Cordes, Thomas and Jöllenbeck, Thomas and Vogt, Lutz}}, issn = {{1813-7253}}, journal = {{European Review of Aging and Physical Activity}}, keywords = {{Geriatrics and Gerontology}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{An interrater reliability study of gait analysis systems with the dual task paradigm in healthy young and older adults}}}, doi = {{10.1186/s11556-021-00271-z}}, volume = {{18}}, year = {{2021}}, } @article{40598, author = {{Rudisch, Julian and Jöllenbeck, Thomas and Vogt, Lutz and Cordes, Thomas and Klotzbier, Thomas Jürgen and Vogel, Oliver and Wollesen, Bettina}}, issn = {{0966-6362}}, journal = {{Gait & Posture}}, keywords = {{Rehabilitation, Orthopedics and Sports Medicine, Biophysics}}, pages = {{55--64}}, publisher = {{Elsevier BV}}, title = {{{Agreement and consistency of five different clinical gait analysis systems in the assessment of spatiotemporal gait parameters}}}, doi = {{10.1016/j.gaitpost.2021.01.013}}, volume = {{85}}, year = {{2021}}, } @article{30119, abstract = {{Abstract Background Subjective Memory Complaints (SMC) in elderly people due to preclinical Alzheimer’s Disease may be associated with dysregulation of the Kynurenine Pathway (KP), with an increase in neurotoxic metabolites that affect cognition. Golf is a challenging sport with high demands on motor, sensory, and cognitive abilities, which might bear the potential to attenuate the pathological changes of preclinical AD. This trial investigated the feasibility of learning to play golf for elderly with cognitive problems and its effects on cognitive functions and the KP. Methods In a 22-week single-blinded randomized controlled trial, elderly people with SMC were allocated to the golf (n = 25, 180 min training/week) or control group (n = 21). Primary outcomes were feasibility (golf exam, adherence, adverse events) and general cognitive function (Alzheimer’s Disease Assessment Scale). Secondary outcomes include specific cognitive functions (Response Inhibition, Corsi Block Tapping Test, Trail Making Test), KP metabolites and physical performance (6-Minute-Walk-Test). Baseline-adjusted Analysis-of-Covariance was conducted for each outcome. Results 42 participants were analyzed. All participants that underwent the golf exam after the intervention passed it (20/23). Attendance rate of the golf intervention was 75 %. No adverse events or drop-outs related to the intervention occurred. A significant time*group interaction (p = 0.012, F = 7.050, Cohen’s d = 0.89) was found for correct responses on the Response Inhibition task, but not for ADAS-Cog. Moreover, a significant time*group interaction for Quinolinic acid to Tryptophan ratios (p = 0.022, F = 5.769, Cohen’s d = 0.84) in favor of the golf group was observed. An uncorrected negative correlation between attendance rate and delta Quinolinic acid to Kynurenic acid ratios in the golf group (p = 0.039, r=-0.443) was found as well. Conclusions The findings indicate that learning golf is feasible and safe for elderly people with cognitive problems. Preliminary results suggest positive effects on attention and the KP. To explore the whole potential of golfing and its effect on cognitive decline, a larger cohort should be studied over a longer period with higher cardiovascular demands. Trial registration The trial was retrospectively registered (2nd July 2018) at the German Clinical Trials Register (DRKS00014921). }}, author = {{Stroehlein, Julia K. and Vieluf, Solveig and Zimmer, Philipp and Schenk, Alexander and Oberste, Max and Gölz, Christian Johannes and van den Bongard, Franziska and Reinsberger, Claus}}, issn = {{1471-2377}}, journal = {{BMC Neurology}}, keywords = {{Clinical Neurology, General Medicine}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Learning to play golf for elderly people with subjective memory complaints: feasibility of a single‐blinded randomized pilot trial}}}, doi = {{10.1186/s12883-021-02186-9}}, volume = {{21}}, year = {{2021}}, }