@article{54933, abstract = {{In some patients with atypical cystic fibrosis (CF), only one allele of the CF transmembrane conductance regulator (CFTR) gene is affected. Mutations of the epithelial sodium channel (ENaC) may contribute to the pathophysiology of the disease in these patients. To functionally characterize a mutation in the $\beta$-subunit of ENaC ($\beta$V348M) recently identified in a patient with severe CF-like symptoms (Mutesa et al. 2009), we expressed wild-type (wt) $\alpha$$\beta$$\gamma$ENaC or mutant $\alpha$$\beta$V348M$\gamma$ENaC in Xenopus laevis oocytes. The $\beta$V348M mutation stimulated amiloride-sensitive whole-cell current ($\Delta$I(ami)) by $\sim$40% but had no effect on surface expression or single-channel conductance of ENaC. Instead the mutation increased channel open probability (P(o)). Proteolytic activation of mutant ENaC by chymotrypsin was reduced compared with that of wt ENaC ($\sim$3.0-fold vs. $\sim$4.2-fold), which is consistent with the increased baseline P(o) of mutant ENaC. Similarly, the ENaC activator S3969 stimulated mutant ENaC currents to a lesser degree (by $\sim$2.6-fold) than wt ENaC currents (by $\sim$3.5-fold). The gain-of-function effect of the $\beta$V348M mutation was confirmed by whole-cell current measurements in HEK293 cells transiently transfected with wt or mutant ENaC. Computational channel modeling in combination with functional expression of different $\beta$V348 mutants in oocytes suggests that the $\beta$V348M mutation increases channel P(o) by destabilizing the closed channel state. Our findings indicate that the gain-of-function effect of the $\beta$V348M mutation may contribute to CF pathophysiology by inappropriately increasing sodium and fluid absorption in the respiratory tract.}}, author = {{Rauh, Robert and Soell, Daniel and Haerteis, Silke and Diakov, Alexei and Nesterov, Viatcheslav and Krueger, Bettina and Sticht, Heinrich and Korbmacher, Christoph}}, journal = {{American Journal of Physiology-Lung Cellular and Molecular Physiology}}, number = {{1}}, pages = {{L43–L55}}, publisher = {{American Physiological Society}}, title = {{{A mutation in the $\beta$-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect}}}, doi = {{10.1152/ajplung.00093.2012}}, volume = {{304}}, year = {{2013}}, } @inbook{28950, author = {{Grimminger-Seidensticker, Elke}}, booktitle = {{Sportpädagogik zwischen Stillstand und Beliebigkeit}}, editor = {{Gogoll, A. and Messmer, R.}}, pages = {{166--171}}, publisher = {{Bundesamt für Sport BASPO}}, title = {{{Selbstbezogene Facetten und Anerkennungs- bzw. Missachtungserfahrungen im Sportunterricht}}}, year = {{2013}}, } @article{28889, author = {{Grimminger-Seidensticker, Elke}}, journal = {{Zeitschrift für sportpädagogische Forschung}}, number = {{1}}, pages = {{55--77}}, title = {{{Besondere Sichtbarkeit durch Unsichtbarkeit – Wie sich Schüler/innen untereinander grundlegende Anerkennung im Sportunterricht verweigern}}}, volume = {{1}}, year = {{2013}}, } @article{28885, author = {{Grimminger-Seidensticker, Elke}}, journal = {{Physical Education and Sport Pedagogy}}, number = {{5}}, pages = {{506--519}}, title = {{{Sport Motor Competencies and the Experience of Social Recognition among Peers in Physical Education – A Video-based Study}}}, volume = {{18}}, year = {{2013}}, } @article{28887, author = {{Grimminger-Seidensticker, Elke}}, journal = {{Unterrichtswissenschaft}}, number = {{4}}, pages = {{348--362}}, title = {{{Szenen des Helfens zwischen Schüler/innen im Sportunterricht – Eine videobasierte Studie}}}, volume = {{41}}, year = {{2013}}, } @misc{37412, author = {{Bigga, Regine}}, booktitle = {{Haushalt in Bildung und Forschung}}, issn = {{2193-8806}}, publisher = {{Verlag Barbara Budrich}}, title = {{{Ernährung- und Konsumbildung}}}, year = {{2013}}, } @article{31721, author = {{Tanaka, N and Liu, H and Reinsberger, Claus and Madsen, JR and Bourgeois, BF and Dworetzky, BA and Hämäläinen, MS and Stufflebeam, SM}}, issn = {{0195-6108}}, journal = {{AJNR Am J Neuroradiol}}, number = {{3}}, pages = {{558--563}}, title = {{{Language lateralization represented by spatiotemporal mapping of magnetoencephalography.}}}, volume = {{34}}, year = {{2013}}, } @article{46712, author = {{Güldenpenning, Iris and Steinke, Andreas and Koester, Dirk and Schack, Thomas}}, journal = {{Experimental Brain Research}}, pages = {{333–343}}, publisher = {{Springer}}, title = {{{Athletes and novices are differently capable to recognize feint and non-feint actions}}}, doi = {{https://doi.org/10.1007/s00221-013-3658-2}}, volume = {{230}}, year = {{2013}}, } @inproceedings{46876, author = {{Schütz, Christoph and Güldenpenning, Iris and Schack, Thomas}}, booktitle = {{Abstracts of the 55th Conference of Experimental Psychologists (TeaP)}}, editor = {{Ansorg, U. and Kirchler, E. and Lamm, C. and Leder, H.}}, location = {{Wien}}, pages = {{259}}, publisher = {{Pabst Science Publishers}}, title = {{{Unconscious, incongruent primes initiate invalid motor actions}}}, doi = {{https://doi.org/10.23668/psycharchives.880}}, year = {{2013}}, } @inproceedings{46878, author = {{Güldenpenning, Iris and Schäfer, A and Selig, C and Schack, Thomas}}, booktitle = {{Angewandte Sportpsychologie. 45. Jahrestagung der Arbeitsgemeinschaft für Sportpsychologie (asp)}}, editor = {{Stoll, O. and Lau, A. and Moczall, S.}}, location = {{Halle/Saale}}, pages = {{104}}, publisher = {{Feldhaus Edition Czwalina}}, title = {{{Ich sehe was, was du nicht siehst–Die unbewusste Verarbeitung von Blicktäuschungen im Basketball}}}, year = {{2013}}, } @inproceedings{46874, author = {{Schütz, Christoph and Güldenpenning, Iris and Schack, Thomas}}, booktitle = {{Angewandte Sportpsychologie. 45. Jahrestagung der Arbeitsgemeinschaft für Sportpsychologie (asp)}}, editor = {{Stoll, O. and Lau, A. and Moczall, S.}}, location = {{Halle/Saale}}, pages = {{108}}, publisher = {{Feldhaus Edition Czwalina}}, title = {{{Inkongruente, unbewusste Primes können Fehlhandlungen initiieren}}}, year = {{2013}}, } @article{41354, author = {{Kehne, Miriam and Seifert, Andreas and Schaper, Niclas}}, journal = {{Sportunterricht}}, number = {{2}}, pages = {{53--57}}, title = {{{Struktur eines Instruments zur Kompetenzerfassung in der Sportlehrerausbildung.}}}, volume = {{62}}, year = {{2013}}, } @inbook{44651, author = {{Brandl-Bredenbeck, Hans-Peter and Kämpfe, Astrid and Köster, Carolin}}, booktitle = {{Gesundheitsförderung im Setting Schule }}, editor = {{Marchwacka, M. A.}}, pages = {{329--345}}, publisher = {{Springer VS}}, title = {{{Gesundheit von Lehramtsstudierenden: ausgewählte Ergebnisse einer empirischen Untersuchung an der Universität Paderborn}}}, year = {{2013}}, } @book{44650, author = {{Brandl-Bredenbeck, Hans-Peter and Kämpfe, Astrid and Köster, Carolin}}, publisher = {{Meyer & Meyer}}, title = {{{Studium heute - gesundheitsfördernd oder gesundheitsgefährdend?: eine Lebensstilanalyse}}}, year = {{2013}}, } @inbook{56471, author = {{Teubert, Hilke}}, booktitle = {{Sportwissenschaft Grenzenlos?!}}, editor = {{Mess, F and Gruber, M and Woll, A}}, pages = {{303}}, publisher = {{Feldhaus Edition Czwalina}}, title = {{{Funktion und Eignung moderner Sportstadien im Kontext schulischer Berufsorientierung}}}, year = {{2013}}, } @book{56037, author = {{Brandl-Bredenbeck, Hans Peter and Kämpfe, Astrid and Köster, Carolin}}, publisher = {{Meyer & Meyer}}, title = {{{Studium heute - gesundheitsfördernd oder gesundheitsgefährdend? Eine Lebensstilanalyse.}}}, year = {{2013}}, } @article{57701, author = {{Neuhaus, Dorothee}}, journal = {{Zeitschrift für Sportpsychologie}}, number = {{3}}, pages = {{119}}, title = {{{Sportpsychologie Digest}}}, doi = {{10.1026/1612-5010/a000101}}, volume = {{20}}, year = {{2013}}, } @inproceedings{57715, author = {{Jöllenbeck, Thomas and Beck, K and Neuhaus, Dorothee and Pietschmann, J and Wawer, C}}, booktitle = {{22. Rehabilitationswissenschaftliches Kolloquium: Teilhabe 2.0 - Reha neu denken? DRV Schriften}}, pages = {{374--377}}, title = {{{Feedback-Training zum Erlernen einer vorgegeben Teilbelastung beim Gehen mit Gehstützen}}}, volume = {{101}}, year = {{2013}}, } @inproceedings{57717, author = {{Jöllenbeck, Thomas and Beck, K and Grebe, B and Neuhaus, Dorothee and Pietschmann, J and Wawer, C}}, booktitle = {{Motorische und kognitive Leistungsfähigkeiten über die Lebensspanne}}, editor = {{Schott, N}}, pages = {{37}}, publisher = {{Druckerei Wir machen Druck GmbH}}, title = {{{Feedbacktraining zum Erlernen einer vorgegebenen Teilbelastung beim Gang mit Gehstützen in der orthopädischen Rehabilitation}}}, year = {{2013}}, } @inproceedings{57718, author = {{Neuhaus, Dorothee}}, booktitle = {{Motorische und kognitive Leistungsfähigkeit über die Lebensspanne}}, editor = {{Schott, N}}, pages = {{119}}, publisher = {{Druckerei Wir machen Druck GmbH}}, title = {{{Zum Einfluss von zusätzlichen Instruktionen bei unterschiedlichen Fokusbedingungen auf das bi- & monopedale Stehen auf einem Luftkissen}}}, year = {{2013}}, }