@article{63659, abstract = {{ Objectives To date, consistent evidence for consequences of heading in football (soccer) on the structure and function of the brain is lacking, but first studies indicate a potential effect of specific high-magnitude headers. The purpose of this longitudinal, prospective study was to investigate whether potential structural and/or functional alterations within the brain were associated with (high-magnitude) heading. Methods 3T MRI sequences were obtained from active high-level male players before and after an observation period of 17.2 months (median). Cortical thickness and grey matter (GM) volume were investigated on a whole-brain level. Functional connectivity (FC) was analysed in the default mode network (DMN) and salience network (SN). During the observation period, each training and each match was videotaped and evaluated regarding the heading exposure. Significant structural and functional findings were subsequently correlated with specific header characteristics. Results 14 included participants (mean age: 20.36±3.34 years) played 5822 headers. GM volume remained unchanged, whereas cortical thickness decreased minimally from pre-measurement to post-measurement in a left precentral region (mean change: 0.048±0.128 mm; clusterwise p=0.0416). Within the SN, FC increased in one cluster (false discovery rate corrected p=0.026). FC remained stable within the DMN and between DMN and SN. Change from pre-measurement to post-measurement for the significant results did not correlate with heading variables. Conclusion Our findings may indicate no cumulative effect of heading during the observation period. As these results contrast with cross-sectional findings, more longitudinal, prospective studies with a greater sample size are urgently needed to understand potential heading effects. }}, author = {{Mund, Franziska Katharina and Feddermann-Demont, Nina and Welsch, Goetz H and Schuenemann, Carsten and Fiehler, Jens and Thaler, Christian and Meyer, Lukas and Reeschke, Rebecca and Reinsberger, Claus}}, issn = {{2055-7647}}, journal = {{BMJ Open Sport & Exercise Medicine}}, number = {{4}}, publisher = {{BMJ}}, title = {{{High-magnitude headers are not associated with structural and functional brain changes in active high-level football (soccer) players}}}, doi = {{10.1136/bmjsem-2025-002636}}, volume = {{11}}, year = {{2025}}, } @article{61003, author = {{Hasija, Tanuj and Kuschel, Maurice and Jackson, Michele and Dailey, Stephanie and Menne, Henric and Reinsberger, Claus and Vieluf, Solveig and Loddenkemper, Tobias}}, issn = {{0933-3657}}, journal = {{Artificial Intelligence in Medicine}}, publisher = {{Elsevier BV}}, title = {{{Improving wearable-based seizure prediction by feature fusion using an explainable growing network}}}, doi = {{10.1016/j.artmed.2025.103228}}, volume = {{169}}, year = {{2025}}, } @article{60996, abstract = {{Abstract The benefits of physical activity are undisputed. However, adverse events can occur in rare cases, particularly during high-intensity or prolonged exercise. During physical activity, at-risk patients can experience major cardiac events, whereas adverse events affecting the musculoskeletal system are more common but less severe. A sports preparticipation evaluation (PPE) for apparently healthy adults is designed to detect at-risk individuals and prevent potentially fatal events. This guideline for conducting PPEs was developed by consensus among 16 medical societies and sports associations and is based on previously published guidelines and consensus papers. Sports medicine physicians and potential participants were also surveyed to assess the recommendations’ content, feasibility, and implementation. On the basis of the 20 recommendations developed and agreed upon by the abovementioned entities, PPE comprises individuals’ personal, family, and sports histories, as well as a physical examination. The need for additional examinations (e.g., laboratory parameters, echocardiograms, or stress tests) is determined on the basis of the PPE findings. This approach’s feasibility in various regions, including resource-limited settings, and the extent to which it prevents adverse or potentially fatal events, should be examined in future research.}}, author = {{Joisten, Christine and Hirschmüller, Anja and Bauer, Pascal and Baum, Erika and Behrens, Meinolf and Berrisch-Rahmel, Susanne and Berrsche, Gregor and Carlsohn, Anja and Cassel, Michael and DeZeuuw, Justus and Dörr, Gesine and Dreher, Michael and Edelmann, Frank and Esefeld, Katrin and Freitag, Michael and Grebe, Mathias and Grim, Casper and Janßen, Pia and Kaiser, Rolf and Katlun, Thomas and Köppel, Maximilian and Kreutz, Charlotte and Krüger, Karsten and Lutter, Christoph and Mayer, Frank and Moser, Othmar and Nieß, Andreas and Predel, Hans-Georg and Peters, Stefan and Platen, Petra and Portius, Dorothea and Reinsberger, Claus and Reiss, Nils and Röcker, Kai and Schmidt, Thomas and Schmidt-Trucksäss, Arno and Schmitt, Holger and Schramm, Thomas and Sturm, Christian and Vater, Hans and Weise, Alina and Weisser, Burkhard and Welsch, Götz and Winkelmann, Andreas and Wirth, Alfred and Wolfarth, Bernd and Goossen, Käthe}}, issn = {{0112-1642}}, journal = {{Sports Medicine}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Sports Preparticipation Evaluation for Healthy Adults: A Consensus-Based German Guideline}}}, doi = {{10.1007/s40279-025-02230-5}}, year = {{2025}}, } @article{61006, abstract = {{ Objective This cross-sectional study aimed to investigate subjective and objective deficits of neurocognitive function, balance and vestibulo-ocular performance in athletes with sport-related concussion (SRC) compared with healthy control athletes. Methods 72 patients with SRC and 72 matched healthy controls were included. All participants performed computerised testing of neurocognitive function, device-assisted balance testing and objective evaluation of vestibulo-ocular function (video head impulse and dynamic visual acuity test). Clinical symptom clusters (headache/migraine, anxiety/mood, fatigue, cognitive, vestibular, ocular) were determined for each patient using the Sport Concussion Assessment Tool, 5th edition symptom evaluation. Independent t-tests or Mann-Whitney U tests were calculated to test for group differences in the whole cohort and according to clinical symptom clusters. Results When investigating the whole cohort, significant differences between patients with SRC and control subjects were found in one parameter of balance testing (sway velocity double-firm), with lower performance in the SRC group (p<0.001, r=0.345). The number of symptom clusters assigned to the SRC patients ranged from 0 (no definite cluster) to 6 (all clusters), and all clusters were frequent in the investigated cohort. Patients with vestibular, cognitive and fatigue symptom clusters demonstrated significantly lower performance in balance testing compared with SRC patients without those clusters (p<0.001 to p=0.005, r=0.368–0.439). Additionally, SRC patients presenting with symptoms of the fatigue cluster demonstrated significantly worse performance in vestibulo-ocular testing compared with SRC patients without the fatigue cluster (p=0.006, d=0.781). Conclusion SRC patients presented with variable numbers and qualities of clinical symptom clusters. Some subjective clusters were associated with abnormal objective tests of other clusters (vestibular, cognitive and fatigue with abnormal balance; and fatigue with abnormal vestibulo-ocular performance). Clinical symptom clusters and their overlap should be considered when examining patients with SRC. }}, author = {{Weike, Lea and Reeschke, Rebecca and Reinsberger, Claus}}, issn = {{2055-7647}}, journal = {{BMJ Open Sport & Exercise Medicine}}, number = {{3}}, publisher = {{BMJ}}, title = {{{Clinical symptom clusters, neurocognitive function, balance and vestibulo-ocular function in athletes with sport-related concussion}}}, doi = {{10.1136/bmjsem-2024-002447}}, volume = {{11}}, year = {{2025}}, } @article{61000, author = {{van den Bongard, Franziska and Petersen, Catharina and Reinsberger, Claus}}, issn = {{2589-9864}}, journal = {{Epilepsy & Behavior Reports}}, publisher = {{Elsevier BV}}, title = {{{Safety and feasibility of exhaustive exercise testing for people with epilepsy}}}, doi = {{10.1016/j.ebr.2025.100762}}, volume = {{30}}, year = {{2025}}, } @article{61007, abstract = {{ABSTRACT Purpose Repetitive head impacts due to heading in soccer may bear the potential to induce brain changes. To investigate how brain development is affected by heading, effects of heading exposure on neurocognitive and vestibular performance in adolescent soccer players were prospectively examined. Methods In this longitudinal cohort study, male and female high-level youth soccer players of different ages were enrolled in two seasons. Age-matched athletes of other ball sports were included as controls. Before and after each season, neurocognitive performance (6 domain scores), vestibulo-ocular reflex, dynamic visual acuity, and postural control (sway velocity) were objectively assessed in all athletes. Every soccer training and match during the observation period was videotaped to analyze individual heading exposure. Associations between heading frequency (total, in duels, >20 m flight distance) and pre- to post-changes were investigated via Spearman correlation. Results 103 soccer and 51 control athletes (9-19 years) participated. Neurocognitive scores and sway velocity significantly improved in each season in soccer and control athletes. There were no associations between total heading numbers and changes in any parameter. Over the first season, the more headers played in duels (r = -0.255, 95%CI = -0.474 to -0.006, p = 0.04) and from >20 m distance (r = -0.299, 95%CI = -0.510 to -0.055, p = 0.02) the less psychomotor speed improvement occurred. In the second season, improvements in reaction time were significantly smaller with higher numbers of headers played in duels (r = 0.375, 95%CI = 0.043 to 0.632, p = 0.02) and from >20 m distance (r = 0.359, 95%CI = 0.025 to 0.621, p = 0.03). Conclusions Potential high-impact headers may have affected neurocognitive improvements, exhibiting small to moderate effects. Therefore, more high-impact headers may be more important to consider than solely the overall heading exposure in discussions about adverse effects in youth soccer. }}, author = {{Reeschke, Rebecca and Dautzenberg, Lena and Mund, Franziska Katharina and Koch, Thorsten and Reinsberger, Claus}}, issn = {{1530-0315}}, journal = {{Medicine & Science in Sports & Exercise}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Effects of Different Header Types on Neurocognitive and Vestibular Performance in Youth Soccer Players}}}, doi = {{10.1249/mss.0000000000003831}}, year = {{2025}}, } @article{60719, abstract = {{Abstract Background Parkinson’s Disease (PD) bears a variety of sex differences and is associated with cardiovascular dysregulation (CDR). Variation in the routinely assessed standard parameters heart rate (HR) and blood pressure (BP) seem not well understood within the frame of sex-specific developments under therapy. Parameters of heart rate variability (RMSSD) and electrodermal activity (meanEDA) may assist the understanding of underlying autonomic developments. This pilot study aims to describe sex-specific cardiovascular and autonomic responses to a multimodal inpatient rehabilitation program in patients with PD. Methods Forty-one PD patients (24 male, 17 female) participated in a stationary, multimodal therapy intervention (MTI). Before and after MTI, HR, BP, RMSSD, and meanEDA were assessed in supine baseline (5 min of rest before orthostasis) and during supine adaption to rest (5 min of rest after orthostasis). Differences between baseline and adaption to rest as well as differences over time of MTI were calculated using Wilcoxon test; sex differences using Mann–Whitney-U test. Results Before MTI, women’s supine HR (p = .034*; d = .17) and BP (p = .015*, d = 0.4) were significantly higher during adaption to rest than during baseline. After MTI, women’s supine HR (p = .020*; d = .84) and BP (p = .022*, d = 0.5) during adaption to rest had decreased significantly. Men’s HR and BP remained constant and without differences between the supine conditions. RMSSD and meanEDA remained steady in both sexes. Conclusion The sex-specific responsiveness to MTI supports the concept of sex-sensitive therapeutic management for cardiovascular symptoms in PD. In both sexes, peripheral cardiovascular outcomes appeared not attributable to corresponding outcomes in autonomic regulation. Further examination of autonomic parameters could provide a foundation for developing therapeutic approaches that address central nervous system mechanisms. The study was officially registered (08/2020). The data supporting the findings of this study are available under http://apps.who.int/trialsearch/ under trial number DRKS00022773. }}, author = {{Siche-Pantel, Franziska and Mühlenberg, Manfred and Buschfort, Rüdiger and Michels, Heinke and Jakobsmeyer, Rasmus and Oesterschlink, Julian and Reinsberger, Claus}}, issn = {{1471-2377}}, journal = {{BMC Neurology}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study}}}, doi = {{10.1186/s12883-025-04281-7}}, volume = {{25}}, year = {{2025}}, } @article{50798, abstract = {{Abstract Background An infection with SARS-CoV-2 can lead to a variety of symptoms and complications, which can impair athletic activity. Objective We aimed to assess the clinical symptom patterns, diagnostic findings, and the extent of impairment in sport practice in a large cohort of athletes infected with SARS-CoV-2, both initially after infection and at follow-up. Additionally, we investigated whether baseline factors that may contribute to reduced exercise tolerance at follow-up can be identified. Methods In this prospective, observational, multicenter study, we recruited German COVID elite-athletes (cEAs, n = 444) and COVID non-elite athletes (cNEAs, n = 481) who tested positive for SARS-CoV-2 by PCR (polymerase chain reaction test). Athletes from the federal squad with no evidence of SARS-CoV-2 infection served as healthy controls (EAcon, n = 501). Questionnaires were used to assess load and duration of infectious symptoms, other complaints, exercise tolerance, and duration of training interruption at baseline and at follow-up 6 months after baseline. Diagnostic tests conducted at baseline included resting and exercise electrocardiogram (ECG), echocardiography, spirometry, and blood analyses. Results Most acute and infection-related symptoms and other complaints were more prevalent in cNEA than in cEAs. Compared to cEAs, EAcon had a low symptom load. In cNEAs, female athletes had a higher prevalence of complaints such as palpitations, dizziness, chest pain, myalgia, sleeping disturbances, mood swings, and concentration problems compared to male athletes (p < 0.05). Until follow-up, leading symptoms were drop in performance, concentration problems, and dyspnea on exertion. Female athletes had significantly higher prevalence for symptoms until follow-up compared to male. Pathological findings in ECG, echocardiography, and spirometry, attributed to SARS-CoV-2 infection, were rare in infected athletes. Most athletes reported a training interruption between 2 and 4 weeks (cNEAs: 52.9%, cEAs: 52.4%), while more cNEAs (27.1%) compared to cEAs (5.1%) had a training interruption lasting more than 4 weeks (p < 0.001). At follow-up, 13.8% of cNEAs and 9.9% of cEAs (p = 0.24) reported their current exercise tolerance to be under 70% compared to pre-infection state. A persistent loss of exercise tolerance at follow-up was associated with persistent complaints at baseline, female sex, a longer break in training, and age > 38 years. Periodical dichotomization of the data set showed a higher prevalence of infectious symptoms such as cough, sore throat, and coryza in the second phase of the pandemic, while a number of neuropsychiatric symptoms as well as dyspnea on exertion were less frequent in this period. Conclusions Compared to recreational athletes, elite athletes seem to be at lower risk of being or remaining symptomatic after SARS-CoV-2 infection. It remains to be determined whether persistent complaints after SARS-CoV-2 infection without evidence of accompanying organ damage may have a negative impact on further health and career in athletes. Identifying risk factors for an extended recovery period such as female sex and ongoing neuropsychological symptoms could help to identify athletes, who may require a more cautious approach to rebuilding their training regimen. Trial Registration Number DRKS00023717; 06.15.2021—retrospectively registered. }}, author = {{Widmann, Manuel and Gaidai, Roman and Schubert, Isabel and Grummt, Maximilian and Bensen, Lieselotte and Kerling, Arno and Quermann, Anne and Zacher, Jonas and Vollrath, Shirin and Bizjak, Daniel Alexander and Beckendorf, Claudia and Egger, Florian and Hasler, Erik and Mellwig, Klaus-Peter and Fütterer, Cornelia and Wimbauer, Fritz and Vogel, Azin and Schoenfeld, Julia and Wüstenfeld, Jan C. and Kastner, Tom and Barsch, Friedrich and Friedmann-Bette, Birgit and Bloch, Wilhelm and Meyer, Tim and Mayer, Frank and Wolfarth, Bernd and Roecker, Kai and Reinsberger, Claus and Haller, Bernhard and Niess, Andreas M. and Birnbaum, Mike Peter and Burgstahler, Christof and Cassel, Michael and Deibert, Peter and Esefeld, Katrin and Erz, Gunnar and Greiss, Franziska and Halle, Martin and Hesse, Judith and Keller, Karsten and Kopp, Christine and Matits, Lynn and Predel, Hans Georg and Rüdrich, Peter and Schneider, Gerald and Stapmanns, Philipp and Steinacker, Jürgen Michael and Szekessy, Sarah and Venhorst, Andreas and Zapf, Stephanie and Zickwolf, Christian}}, issn = {{0112-1642}}, journal = {{Sports Medicine}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{COVID-19 in Female and Male Athletes: Symptoms, Clinical Findings, Outcome, and Prolonged Exercise Intolerance—A Prospective, Observational, Multicenter Cohort Study (CoSmo-S)}}}, doi = {{10.1007/s40279-023-01976-0}}, year = {{2024}}, } @article{55402, author = {{Mund, Franziska Katharina and Feddermann-Demont, Nina and Welsch, Götz and Schuenemann, Carsten and Fiehler, Jens and Junge, Astrid and Reinsberger, Claus}}, issn = {{1440-2440}}, journal = {{Journal of Science and Medicine in Sport}}, publisher = {{Elsevier BV}}, title = {{{Heading during the season and its potential impact on brain structure and neurocognitive performance in high-level male football players: An observational study}}}, doi = {{10.1016/j.jsams.2024.05.012}}, year = {{2024}}, } @article{61002, abstract = {{AbstractIctal and interictal activity within the autonomic nervous system is characterized by a sympathetic overshoot in people with epilepsy. This autonomic dysfunction is assumed to be driven by alterations in the central autonomic network. In this study, exercise-induced changes of the interrelation of central and peripheral autonomic activity in patients with epilepsy was assessed. 21 patients with epilepsy (16 seizure-free), and 21 healthy matched controls performed an exhaustive bicycle ergometer test. Immediately before and after the exercise test, resting state electroencephalography measurements (Brain Products GmbH, 128-channel actiCHamp) of 5 min were carried out to investigate functional connectivity assessed by phase locking value in source space for whole brain, central autonomic network and visual network. Additionally, 1-lead ECG (Brain products GmbH) was performed to analyze parasympathetic (root mean square of successive differences (RMSSD) of the heart rate variability) and sympathetic activity (electrodermal activity (meanEDA)). MeanEDA increased (p < 0.001) and RMSSD decreased (p < 0.001) from pre to post-exercise in both groups. Correlation coefficients of meanEDA and central autonomic network functional connectivity differed significantly between the groups (p = 0.004) after exercise. Both patients with epilepsy and normal control subjects revealed the expected physiological peripheral autonomic responses to acute exhaustive exercise, but alterations of the correlation between central autonomic and peripheral sympathetic activity may indicate a different sympathetic reactivity after exercise in patients with epilepsy. The clinical relevance of this finding and its modulators (seizures, anti-seizure medication, etc.) still needs to be elucidated.}}, author = {{van den Bongard, Franziska and Gowik, Julia Kristin and Coenen, Jessica and Jakobsmeyer, Rasmus and Reinsberger, Claus}}, issn = {{0014-4819}}, journal = {{Experimental Brain Research}}, number = {{6}}, pages = {{1301--1310}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls}}}, doi = {{10.1007/s00221-024-06792-0}}, volume = {{242}}, year = {{2024}}, } @article{60999, abstract = {{AbstractSport-related concussion (SRC) is a complex brain injury. By applying graph-theoretical analysis to networks derived from neuroimaging techniques, studies have shown that despite an overall retention of small-world topology, changes in small-world properties occur after brain injury. Less is known about how exercise during athletes’ return to sport (RTS) influences these brain network properties. Therefore, in the present study dense electroencephalography (EEG) datasets were collected pre- and post-moderate aerobic exercise. Small-world properties of whole brain (WB) and the default mode network (DMN) were extracted from the EEG datasets of 21 concussed athletes and 21 healthy matched controls. More specifically, path length (LP), clustering coefficient (CP), and small-world index (SWI) in binary and weighted graphs were calculated in the alpha frequency band (7–13 Hz). Pre-exercise, SRC athletes had higher DMN-CP values compared to controls, while post-exercise SRC athletes had higher WB-LP compared to controls. Weighted WB analysis revealed a significant association between SRC and the absence of small-world topology (SWI ≤ 1) post-exercise. This explorative study provides preliminary evidence that moderate aerobic exercise during athletes’ RTS induces an altered network response. Furthermore, this altered response may be related to the clinical characteristics of the SRC athlete.}}, author = {{Coenen, Jessica and Strohm, Michael and Reinsberger, Claus}}, issn = {{2045-2322}}, journal = {{Scientific Reports}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Impact of moderate aerobic exercise on small-world topology and characteristics of brain networks after sport-related concussion: an exploratory study}}}, doi = {{10.1038/s41598-024-74474-6}}, volume = {{14}}, year = {{2024}}, } @article{61009, author = {{Coenen, Jessica and van den Bongard, Franziska and Delling, Anne Carina and Reinsberger, Claus}}, issn = {{0897-7151}}, journal = {{Journal of Neurotrauma}}, number = {{5-6}}, pages = {{367--378}}, publisher = {{Mary Ann Liebert Inc}}, title = {{{Differences in Network Functional Connectivity in Response to Sub-Symptomatic Exercise Between Elite Adult Athletes after Sport-Related Concussion and Healthy Matched Controls: A Pilot Study}}}, doi = {{10.1089/neu.2023.0629}}, volume = {{42}}, year = {{2024}}, } @article{60994, author = {{Reinsberger, Claus and Gardner, Andrew J.}}, issn = {{1440-2440}}, journal = {{Journal of Science and Medicine in Sport}}, number = {{4}}, pages = {{211--212}}, publisher = {{Elsevier BV}}, title = {{{Advancing concussion research – follow the yellow brick road}}}, doi = {{10.1016/j.jsams.2024.03.008}}, volume = {{27}}, year = {{2024}}, } @article{60997, author = {{Oesterschlink, Julian and Reinsberger, Claus}}, issn = {{2731-7145}}, journal = {{Die Orthopädie}}, number = {{6}}, pages = {{415--419}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Kopfverletzungen: Was der Teamarzt wissen sollte Head injuries: What the team physician needs to know}}}, doi = {{10.1007/s00132-024-04507-5}}, volume = {{53}}, year = {{2024}}, } @article{42118, author = {{Haase, Franziska Katharina and Prien, Annika and Douw, Linda and Feddermann‐Demont, Nina and Junge, Astrid and Reinsberger, Claus}}, issn = {{0905-7188}}, journal = {{Scandinavian Journal of Medicine & Science in Sports}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, publisher = {{Wiley}}, title = {{{Cortical thickness and neurocognitive performance in former high‐level female soccer and non‐contact sport athletes}}}, doi = {{10.1111/sms.14324}}, year = {{2023}}, } @article{46137, abstract = {{Zusammenfassung Einleitung Motorische Symptome bei Morbus Parkinson lassen sich durch körperliche Aktivität modifizieren. Inwiefern dies auch für nicht-motorische, autonome Symptome gilt, ist weitaus weniger bekannt. Die Erkrankung weist zudem eine Vielzahl an geschlechterspezifischen Unterschieden auf. Epidemiologische Untersuchungen deuten zum Beispiel auf einen besseren primärpräventiven Effekt durch körperliche Aktivität bei Männern als bei Frauen hin. Daten zu geschlechterspezifischen Effekten auf das autonome Nervensystem sind jedoch limitiert. Im Rahmen der vorliegenden Pilotstudie sollen mögliche geschlechterspezifische Effekte einer Bewegungsintervention auf Störungen der hämodynamischen Regulation als Manifestation nicht-motorischer Symptome untersucht werden. Diese sind aufgrund ihrer oft gegensätzlichen hypo- und hypertonen Ausprägung schwierig medikamentös zu behandeln, lassen sich aber gegebenenfalls durch Bewegungsinterventionen modifizieren. Methodik Bei 42 Patienten und Patientinnen (Alter: 70,3 Jahre; 24 Männer; 18 Frauen) wurden vor und nach einer mehrwöchigen, stationären Parkinsonkomplexbehandlung hämodynamische Parameter in einem Schellongtest untersucht. Mittels anschließender Regressionsanalyse erfolgte eine Quantifizierung der Abhängigkeit von den Faktoren Alter, Body Mass Index, Krankheitsdauer, Vorerkrankungen, Sitzendblutdruck und hypotensiv wirkender Medikamente. Ergebnis Bei 44% der Männer und 46% der Frauen traten hämodynamische Regulationsstörungen im Stand und in Rückenlage mindestens einmal auf. Eine vor Therapiebeginn präsentierte Regulationsstörung im Stand zeigte sich in keiner Geschlechtergruppe durch die Parkinsonkomplexbehandlung verändert. Frauen zeigten zu Therapieende jedoch einen signifikant niedrigeren Blutdruck im Liegen (p=0,022*). Unabhängig von der Komplextherapie fiel der Blutdruck in Rückenlage bei Frauen nach Orthostasebelastung höher aus als davor (vor Therapie: p=0,015 *; nach Therapie: p=0,021*). Jedes Lebensjahr erhöhte das Risiko für eine hämodynamische Regulationsstörung in Rückenlage in der Gesamtgruppe um 12,4% (Regressionskoeffizient B=0,117; p=0,014 *; Exp(B)=1,124). Schlussfolgerung Systematische Effekte auf Blutdruckwerte im Rahmen von Orthostasereaktionen durch eine Parkinsonkomplexbehandlung konnten nicht nachgewiesen werden. Allerdings zeigte sich bei Frauen nach Parkinsonkomplexbehandlung eine Senkung der Blutdruckwerte in Rückenlage. Das scheinbar unsystematische, teils geschlechterspezifische Auftreten hämodynamischer Regulationsstörungen fordert ein individualmedizinisch angelegtes Vorgehen im therapeutischen Alltag.}}, author = {{Siche-Pantel, Franziska and Jakobsmeyer, Rasmus and Buschfort, Rüdiger and Mühlenberg, Manfred and Michels, Heinke and Oesterschlink, Julian and Reinsberger, Claus}}, issn = {{1613-0863}}, journal = {{B&G Bewegungstherapie und Gesundheitssport}}, keywords = {{General Medicine}}, number = {{02}}, pages = {{69--77}}, publisher = {{Georg Thieme Verlag KG}}, title = {{{Geschlechterspezifische Effekte in der bewegungstherapeutischen Behandlung von hämodynamischen Regulationsstörungen bei Morbus Parkinson}}}, doi = {{10.1055/a-2023-9443}}, volume = {{39}}, year = {{2023}}, } @article{46136, abstract = {{Zusammenfassung Einleitung Eine sport-assoziierte Concussion (saC) ist eine oftmals unterschätzte Hirnverletzung, die vor allem in Kontakt- und Kollisionssportarten häufig vorkommt. SaCs können zu einer Vielzahl an klinischen Symptomen führen. Akute und zum Teil die klinische Regeneration überdauernde parasympathische Inhibierung im Autonomen Nervensystem (ANS) wurde nach saC bereits häufig beschrieben. Über Veränderungen im sympathischen Nervensystem ist jedoch noch wenig bekannt. Diese wurden durch Messungen der elektrodermalen Aktivität (EDA) im Schlaf, der erheblich zur Regeneration nach saC beiträgt, sowie im Zusammenhang mit subjektiven Symptomen nach saC im Rahmen einer Pilotstudie untersucht. Methode 18 Sportler und Sportlerinnen mit diagnostizierter saC und 18 nach Alter, Geschlecht, Größe, Gewicht, Sportart und Leistungsklasse gematchte Kontrollathleten und -athletinnen trugen in den Nächten während der individuellen Return-to-Sport (RTS) Phase sowie drei Wochen nach Abschluss des RTS (postRTS) einen Handgelenkssensor (E4 Empatica Inc., Mailand, Italien). Anteile nächtlicher tonischer (meanEDA) und phasischer (EDRs, Schlafstürme) EDA wurden zwecks Gruppenvergleich ermittelt und mit saC-Symptomen (SCAT5) sowie dem subjektiven Erholungszustand nach Schlaf mittels Mann-Whitney U-Tests oder ungepaarten t-Tests verglichen. Ergebnisse Während und nach dem RTS konnten keine Gruppenunterschiede in den nächtlichen EDA-Parametern nachgewiesen werden. Eine höhere meanEDA während des RTS korrelierte mit einer höheren Anzahl an Symptomen (p=0,025, r=0,525) und eine erhöhte phasische EDA mit einem geringeren Anstieg des subjektiven Erholungszustands von vor zu nach Schlaf (EDRs: p=0,007, r=−0,642; EDRs/min: p>0,001, r=−0,762; Schlafstürme: p=0,011, r=−0,616). Fazit Die nächtliche EDA nach saC unterschied sich während und nach dem RTS nicht signifikant zu gematchten Kontrollsportlern und -sportlerinnen. Der Zusammenhang zwischen höherer EDA während des RTS und der Anzahl an saC-Symptomen sowie der geringeren subjektiven Erholung nach Schlaf könnte sowohl ursächlich für als auch Effekt der subjektiven Symptome sein und sollte durch Baseline-Messungen und in Kombination mit parasympathischen Markern künftig weiter untersucht werden.}}, author = {{Delling, Anne Carina and Jakobsmeyer, Rasmus and Christiansen, Nele and Coenen, Jessica and Reinsberger, Claus}}, issn = {{1613-0863}}, journal = {{B&G Bewegungstherapie und Gesundheitssport}}, keywords = {{General Medicine}}, number = {{02}}, pages = {{41--48}}, publisher = {{Georg Thieme Verlag KG}}, title = {{{Nächtliche sympathische Aktivität und subjektive Symptome nach sport-assoziierter Concussion: eine Pilotstudie}}}, doi = {{10.1055/a-2023-7579}}, volume = {{39}}, year = {{2023}}, } @article{45859, abstract = {{Sport-related concussions (SRC) are characterized by impaired autonomic control. Heart rate variability (HRV) offers easily obtainable diagnostic approaches to SRC-associated dysautonomia, but studies investigating HRV during sleep, a crucial time for post-traumatic cerebral regeneration, are relatively sparse. The aim of this study was to assess nocturnal HRV in athletes during their return to sports (RTS) after SRC in their home environment using wireless wrist sensors (E4, Empatica, Milan, Italy) and to explore possible relations with clinical concussion-associated sleep symptoms. Eighteen SRC athletes wore a wrist sensor obtaining photoplethysmographic data at night during RTS as well as one night after full clinical recovery post RTS (>3 weeks). Nocturnal heart rate and parasympathetic activity of HRV (RMSSD) were calculated and compared using the Mann–Whitney U Test to values of eighteen; matched by sex, age, sport, and expertise, control athletes underwent the identical protocol. During RTS, nocturnal RMSSD of SRC athletes (Mdn = 77.74 ms) showed a trend compared to controls (Mdn = 95.68 ms, p = 0.021, r = −0.382, p adjusted using false discovery rate = 0.126) and positively correlated to “drowsiness” (r = 0.523, p = 0.023, p adjusted = 0.046). Post RTS, no differences in RMSSD between groups were detected. The presented findings in nocturnal cardiac parasympathetic activity during nights of RTS in SRC athletes might be a result of concussion, although its relation to recovery still needs to be elucidated. Utilization of wireless sensors and wearable technologies in home-based settings offer a possibility to obtain helpful objective data in the management of SRC.}}, author = {{Delling, Anne Carina and Jakobsmeyer, Rasmus and Coenen, Jessica and Christiansen, Nele and Reinsberger, Claus}}, issn = {{1424-8220}}, journal = {{Sensors}}, keywords = {{Electrical and Electronic Engineering, Biochemistry, Instrumentation, Atomic and Molecular Physics, and Optics, Analytical Chemistry}}, number = {{9}}, publisher = {{MDPI AG}}, title = {{{Home-Based Measurements of Nocturnal Cardiac Parasympathetic Activity in Athletes during Return to Sport after Sport-Related Concussion}}}, doi = {{10.3390/s23094190}}, volume = {{23}}, year = {{2023}}, } @article{31727, author = {{Niess, AM and Widmann, M and Gaidai, R and Gölz, C and Schubert, I and Castillo, K and Sachs, JP and Bizjak, D and Vollrath, S and Wimbauer, F and Vogel, A and Keller, K and Burgstahler, C and Quermann, A and Kerling, A and Schneider, G and Zacher, J and Diebold, K and Grummt, M and Beckendorf, C and Buitenhuis, J and Egger, F and Venhorst, A and Morath, O and Barsch, F and Mellwig, KP and Oesterschlink, J and Wüstenfeld, J and Predel, HG and Deibert, P and Friedmann-Bette, B and Mayer, F and Hirschmüller, A and Halle, M and Steinacker, JM and Wolfarth, B and Meyer, T and Böttinger, E and Flechtner-Mors, M and Bloch, W and Haller, B and Roecker, K and Reinsberger, Claus}}, issn = {{1661-8556}}, journal = {{Int J Public Health}}, pages = {{1604414}}, title = {{{COVID-19 in German Competitive Sports: Protocol for a Prospective Multicenter Cohort Study (CoSmo-S).}}}, volume = {{67}}, year = {{2022}}, } @article{36359, author = {{Weber, J and Ernstberger, A and Reinsberger, Claus and Popp, D and Nerlich, M and Alt, V and Krutsch, W}}, issn = {{2052-1847}}, journal = {{BMC Sports Sci Med Rehabil}}, number = {{1}}, pages = {{132}}, title = {{{Video analysis of 100 matches in male semi-professional football reveals a heading rate of 5.7 headings per field player and match.}}}, volume = {{14}}, year = {{2022}}, }