@article{54419, abstract = {{Leaky mode resonances of the setae of Cataglyphis bombycina are found to enhance the thermal emission of the animals by near field coupling to the chitinous exoskeleton. This is remarkable, as the setae are also an adaption to enhance the reflectivity in the visible wavelength range. Both effects are dependent on morphology, dimensions and spatial arrangement. These parameters were experimentally characterized and simulated by finite difference time domain simulations to elucidate the optical impact of the setae in the mid infrared range and the contribution of leaky mode resonances. This mode of action and the setae’s optical properties in the visible range explain evolutionary strains that led to the actual morphology and size of the setae.}}, author = {{Schwind, Bertram and Wu, Xia and Tiemann, Michael and Fabritius, Helge-Otto}}, issn = {{2296-424X}}, journal = {{Frontiers in Physics}}, title = {{{Natural near field coupled leaky-mode resonant anti-reflection structures: the setae of Cataglyphis bombycina}}}, doi = {{10.3389/fphy.2024.1393279}}, volume = {{12}}, year = {{2024}}, } @article{54644, abstract = {{DNA origami nanostructures (DONs) are able to scavenge reactive oxygen species (ROS) and their scavenging efficiency toward ROS radicals was shown to be comparable to that of genomic DNA. Herein, we demonstrate that DONs are highly efficient singlet oxygen quenchers outperforming double‐stranded (ds) DNA by several orders of magnitude. To this end, a ROS mixture rich in singlet oxygen is generated by light irradiation of the photosensitizer methylene blue and its cytotoxic effect on Escherichia coli cells is quantified in the presence and absence of DONs. DONs are found to be vastly superior to dsDNA in protecting the bacteria from ROS‐induced damage and even surpass established ROS scavengers. At a concentration of 15 nM, DONs are about 50 000 times more efficient ROS scavengers than dsDNA at an equivalent concentration. This is attributed to the dominant role of singlet oxygen, which has a long diffusion length and reacts specifically with guanine. The dense packing of the available guanines into the small volume of the DON increases the overall quenching probability compared to a linear dsDNA with the same number of base pairs. DONs thus have great potential to alleviate oxidative stress caused by singlet oxygen in diverse therapeutic settings.}}, author = {{Garcia-Diosa, Jaime Andres and Grundmeier, Guido and Keller, Adrian}}, issn = {{0947-6539}}, journal = {{Chemistry – A European Journal}}, publisher = {{Wiley}}, title = {{{Highly Efficient Quenching of Singlet Oxygen by DNA Origami Nanostructures}}}, doi = {{10.1002/chem.202402057}}, year = {{2024}}, } @inproceedings{55042, author = {{Ponath, Jonas and Bohrmann-Linde, Claudia and Rubner, Isabel and Sommer, Katrin and Fechner, Sabine}}, booktitle = {{Frühe naturwissenschaftliche Bildung}}, editor = {{van Vorst, Helena}}, location = {{Hamburg}}, pages = {{878--881}}, title = {{{Digitalisierungsbezogene Kompetenzen (angehender) Chemielehrkräfte}}}, volume = {{44}}, year = {{2024}}, } @inproceedings{54678, author = {{Rodemer, Marc and Mientus, Lukas and Wiedmann, Julia and Nowak, Anna and Pollmeier, Pascal}}, booktitle = {{Frühe naturwissenschaftliche Bildung }}, editor = {{van Vorst, Helena}}, location = {{Hamburg}}, title = {{{Professionalisierungsmöglichkeiten angehender Lehrkräfte in Praxisphasen}}}, volume = {{44}}, year = {{2024}}, } @article{55310, abstract = {{DNA origami nanostructures are promising carries for drug delivery applications. However, their limited stability under relevant conditions often presents a challenge. Herein, the structural stability of DNA origami nanostructures is investigated in a setting compatible with their application in photodynamic therapy (PDT). To this end, DNA origami triangles and six‐helix bundles (6HBs) are loaded with the clinically tested photosensitizer methylene blue, which upon irradiation with red light generates reactive oxygen species (ROS) that attack the DNA origami nanostructures. ROS‐induced structural damage is observed to depend on the ionic composition of the surrounding medium and becomes more severe at low ionic strength. Mg2+ ions can efficiently protect the DNA origami nanostructures from ROS‐induced damage and may even heal some of the damage obtained under Mg2+‐free conditions when added after irradiation. Finally, the employed DNA origami 6HBs are more resistant toward ROS‐induced structural damage than the triangles, which is attributed to their markedly different mechanical properties. These results thus provide some fundamental insights into the stabilizing role of DNA origami superstructure that may guide the selection or design of DNA origami nanocarriers with optimized stability for their application in PDT.}}, author = {{Rabbe, Lukas and Garcia‐Diosa, Jaime Andres and Grundmeier, Guido and Keller, Adrian}}, issn = {{2688-4062}}, journal = {{Small Structures}}, publisher = {{Wiley}}, title = {{{Ion‐Dependent Stability of DNA Origami Nanostructures in the Presence of Photo‐Generated Reactive Oxygen Species}}}, doi = {{10.1002/sstr.202400094}}, year = {{2024}}, } @article{55371, abstract = {{AbstractThe activation of C(sp3)−F bonds by the commercially available catalyst B(C6F5)3 is reported and applied in reactions with arenes, allylic, vinylic and acetylenic silanes, and olefins to achieve a variety of C−C bond formations (45 examples).}}, author = {{Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, number = {{13}}, pages = {{2933--2938}}, publisher = {{Wiley}}, title = {{{Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds}}}, doi = {{10.1002/adsc.202400511}}, volume = {{366}}, year = {{2024}}, } @inproceedings{55392, abstract = {{In dieser Arbeit werden Untersuchungen zur sauerstoffabhängigen Photolumineszenz von Zink-Zinn-Oxid-Partikeln präsentiert, welche perspektivisch für die optische Sauerstoffdetektion eingesetzt werden sollen. Zink-Zinn-Oxid zeigt eine sauerstoffabhängige Photolumineszenz im sichtbaren Spektralbereich und wird hier als eine photostabile Alternative zu den kommerziell verfügbaren metallorganischen Verbindungen vorgestellt. Der Fokus liegt dabei auf dem Einfluss der Temperatur auf die Sauerstoffsensitivität der Photolumineszenz. Wir zeigen, dass bereits leichte Temperaturerhöhungen zu einer signifikanten Verbesserung der Sauerstoffsensitivität der Photolumineszenz führen und gleichzeitig die Signalqualität erhöhen.}}, author = {{Kothe, Linda and Ester, Stephan and Poeplau, Michael and Wengenroth, Marc and Tiemann, Michael}}, booktitle = {{Proceedings 22. GMA/ITG-Fachtagung Sensoren und Messsysteme 2024}}, isbn = {{978-3-910600-01-0}}, pages = {{66 -- 71}}, title = {{{Stabilisierung von O2-sensitiven Photolumineszenzsignalen durch Temperaturvariation}}}, doi = {{10.5162/sensoren2024/A3.1}}, year = {{2024}}, } @article{59509, abstract = {{AbstractA strategy for multifunctional biosurfaces exploiting multiblock copolymers and the antipolyelectrolyte effect is reported. Combining a polyzwitterionic/antifouling and a polycationic/antibacterial block with a central anchoring block for attachment to titanium oxide surfaces affords surface coatings that exhibit antifouling properties against proteins and allow for surface regeneration by clearing adhering proteins by employing a salt washing step. The surfaces also kill bacteria by contact killing, which is aided by a nonfouling block. The synthesis of block copolymers of 4‐vinyl pyridine (VP), dimethyl 4‐vinylbenzyl phosphonate (DMVBP), and 4‐vinylbenzyltrimethyl ammonium chloride (TMA) is achieved on the multigram scale via RAFT polymerization with good end group retention and narrow dispersities. By polymer analogous reactions, poly(4‐vinyl pyridinium propane sulfonate‐block‐4‐vinylbenzyl phosphonic acid‐block‐4‐vinylbenzyl trimethylammonium chloride) (P(VSP64‐b‐PA14‐b‐TMA64)) is obtained. The antifouling properties against the model protein pepsin and the salt‐induced surface regeneration are shown in surface plasmon resonance (SPR) experiments, while independently the antibacterial and antifouling properties of coated titanium substrates are successfully tested in preliminary microbiological assays against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). This strategy may contribute to the development of long‐term effective antibacterial implant surface coatings to suppress biomedical device‐associated infections.}}, author = {{Methling, Rafael and Greiter, Michael and Al‐Zawity, Jiwar and Müller, Mareike and Schönherr, Holger and Kuckling, Dirk}}, issn = {{1616-5187}}, journal = {{Macromolecular Bioscience}}, keywords = {{antibacterial coatings, antipolyelectrolyte effect, salt switchable polymers, zwitterionic brushes}}, number = {{1}}, publisher = {{Wiley}}, title = {{{Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties}}}, doi = {{10.1002/mabi.202400261}}, volume = {{25}}, year = {{2024}}, } @article{59508, abstract = {{Over the last few decades, nanotechnology has established to be a promising field in medicine. A remaining dominant challenge in today's pharmacotherapy is the limited selectivity of active pharmaceutical ingredients and associated undesirable side effects. Controlled drug release can be promoted by smart drug delivery systems, which release embedded API primarily depending on specific stimuli. Consequently, also the microenvironment of tumor tissue can be used advantageously. Dithiothreitol (DTT) based self-immolative polydisulfides were synthesized that preferentially respond to pathologically increased glutathione (GSH) concentrations, as found in solid tumors. The synthesis with different degrees of polymerisation was investigated as well as the synthesis of a copolymer consisting of dithiothreitol and butanedithiol (BDT). Toxicity tests were carried out on pure polymers and their degradation products. The ability to degrade was examined at pathological and physiological glutathione concentrations in order to test the suitability of the polymer as a matrix for nanoparticulate carrier systems. In addition, the processability of one polymer into nanoparticles was investigated as well as the degradation behaviour with glutathione.}}, author = {{Völlmecke, Katharina and Kramer, Maurice and Horky, Corinna and Dückmann, Oliver and Mulac, Dennis and Langer, Klaus and Kuckling, Dirk}}, issn = {{2046-2069}}, journal = {{RSC Advances}}, number = {{48}}, pages = {{35568--35577}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems}}}, doi = {{10.1039/d4ra07228f}}, volume = {{14}}, year = {{2024}}, } @article{59616, abstract = {{AbstractThe activation of C(sp3)−F bonds by the commercially available catalyst B(C6F5)3 is reported and applied in reactions with arenes, allylic, vinylic and acetylenic silanes, and olefins to achieve a variety of C−C bond formations (45 examples).}}, author = {{Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{fluoride, bond activation, borane, Lewis acid, C-C bond formation}}, number = {{13}}, pages = {{2933--2938}}, publisher = {{Wiley}}, title = {{{Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds}}}, doi = {{10.1002/adsc.202400511}}, volume = {{366}}, year = {{2024}}, } @article{61848, abstract = {{AbstractUnderstanding how water interacts with nanopores of carbonaceous electrodes is crucial for energy storage and conversion applications. A high surface area of carbonaceous materials does not necessarily need to translate to a high electrolyte‐solid interface area. Herein, we study the interaction of water with nanoporous C1N1 materials to explain their very low specific capacitance in aqueous electrolytes despite their high surface area. Water was used to probe chemical environments, provided by pores of different sizes, in 1H MAS NMR experiments. We observe that regardless of their high hydrophilicity, only a negligible portion of water can enter the nanopores of C1N1, in contrast to a reference pure carbon material with a similar pore structure. The common paradigm that water easily enters hydrophilic pores does not apply to C1N1 nanopores below a few nanometers. Calorimetric and sorption experiments demonstrated strong water adsorption on the C1N1 surface, which restricts water mobility across the interface and impedes its penetration into the nanopores.}}, author = {{Lamata‐Bermejo, Irene and Keil, Waldemar and Nolkemper, Karlo and Heske, Julian and Kossmann, Janina and Elgabarty, Hossam and Wortmann, Martin and Chorążewski, Mirosław and Schmidt, Claudia and Kühne, Thomas D. and López‐Salas, Nieves and Odziomek, Mateusz}}, issn = {{1433-7851}}, journal = {{Angewandte Chemie International Edition}}, number = {{50}}, publisher = {{Wiley}}, title = {{{Understanding the Wettability of C1N1 (Sub)Nanopores: Implications for Porous Carbonaceous Electrodes}}}, doi = {{10.1002/anie.202411493}}, volume = {{63}}, year = {{2024}}, } @article{62093, abstract = {{AbstractUnter anderem das hat die Organik im letzten Jahr bewegt: milde Oxidation mit Elektrochemie, Oxidation zu enantiomerenreinen Sulfonylverbindungen, Flüssigkristallphasen erkennen mit maschinellem Lernen, CO2reagiert zu Succinat und Carbamaten, eine Alternative zu Bisphenol A, Subporphyrine, photoschaltbare Spinmaterialien, photochemische Thiophen‐Ringerweiterung, und Peptide werden mit Bor versehen und cyclisiert. Die Zusammenstellung des Trendberichts koordiniert hat Martin Breugst, Universität Chemnitz.}}, author = {{Breugst, Martin and Andexer, Jennifer and Barra, Lena and Beil, Sebastian B. and Breinbauer, Rolf and Burkhardt, Immo and Dumele, Oliver and Ernst, Martin and Gellrich, Urs and Germer, Philipp and Giese, Michael and Huy, Peter and Kath‐Schorr, Stephanie and Klepp, Julian and Körber, Karsten and Kordes, Markus and Kuttruff, Christian A. and Lindel, Thomas and Myllek, Sebastian and Pfrengle, Fabian and Pietruszka, Jörg and Schaschke, Norbert and Senge, Mathias O. and Storch, Golo and Teichert, Johannes F. and Tönjes, Jan and Waldvogel, Siegfried R. and Werner, Thomas and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{44--67}}, publisher = {{Wiley}}, title = {{{Trendbericht Organische Chemie 2024}}}, doi = {{10.1002/nadc.20244139258}}, volume = {{72}}, year = {{2024}}, } @article{62092, author = {{Nyemeck, Suzanne L. and Eyong, Kenneth O. and Bidingha, Ronald and Kamdem, Michael HK. and Ndinteh, Derek T. and Odumosu, Patricia O. and Folefoc, Gabriel N. and Bilanda, Danielle C. and Egbe, Andrew E. and Werner, Thomas and Bekono, Boris D. and Ntie-Kang, Fidele}}, issn = {{1874-3900}}, journal = {{Phytochemistry Letters}}, keywords = {{T4}}, pages = {{59--67}}, publisher = {{Elsevier BV}}, title = {{{Design, isolation, synthesis, and mechanistic insight of flavonoids isolated from Beilschmiedia obscura, as potential α-glucosidase inhibitors}}}, doi = {{10.1016/j.phytol.2024.06.004}}, volume = {{62}}, year = {{2024}}, } @article{62090, abstract = {{The selective N-formylation and N-methylation of amines with carbon dioxide (CO2) catalyzed by methyltriphenylphosphonium methylcarbonate and tuned by polymethylhydrosiloxane or trimethoxysilane as reducing agents is reported.}}, author = {{Ren, Changyue and Terazzi, Constanza and Werner, Thomas}}, issn = {{1463-9262}}, journal = {{Green Chemistry}}, keywords = {{T1, T2, CSSD}}, number = {{1}}, pages = {{439--447}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Tuneable reduction of CO2 – organocatalyzed selective formylation and methylation of amines}}}, doi = {{10.1039/d3gc03993e}}, volume = {{26}}, year = {{2024}}, } @article{62091, author = {{Ren, Changyue and Spannenberg, Anke and Werner, Thomas}}, issn = {{2168-0485}}, journal = {{ACS Sustainable Chemistry & Engineering}}, keywords = {{T1, T2, CSSD}}, number = {{29}}, pages = {{10969--10977}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO2}}}, doi = {{10.1021/acssuschemeng.4c03464}}, volume = {{12}}, year = {{2024}}, } @article{62088, author = {{Tönjes, Jan and Medvarić, Viktorija and Werner, Thomas}}, issn = {{0022-3263}}, journal = {{The Journal of Organic Chemistry}}, keywords = {{T2, CSSD}}, number = {{15}}, pages = {{10729--10735}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis}}}, doi = {{10.1021/acs.joc.4c00985}}, volume = {{89}}, year = {{2024}}, } @article{62236, abstract = {{AbstractDue to its excellent biocompatibility, pure iron is a very promising implant material, but often features corrosion rates that are too low. Using additive manufacturing and modified powders the microstructure and, thus, the material properties, e.g., the corrosion properties, can be tailored for specific applications. Within the scope of this study, pure iron powder was modified with different amounts of CeO2 or Fe2O3 nanoparticles and subsequently processed by Electron Beam Powder Bed Fusion (PBF-EB/M). The corrosion-fatigue behavior of CeO2 and Fe2O3 modified iron was investigated using rotation bending tests under the influence of simulated body fluid (m-SBF). While the modification using Fe2O3 showed reduced fatigue and corrosion-fatigue strengths, it could be demonstrated that the modification with CeO2 is characterized by improved fatigue properties. The superior fatigue properties in air are attributed to the positive impact of dispersion strengthening. Additionally, an increased degradation rate compared to pure iron could be observed, eventually promoting an earlier failure of the specimens in the corrosion fatigue tests.}}, author = {{Wackenrohr, Steffen and Torrent, Christof Johannes Jaime and Herbst, Sebastian and Nürnberger, Florian and Krooss, Philipp and Frenck, Johanna-Maria and Ebbert, Christoph and Voigt, Markus and Grundmeier, Guido and Niendorf, Thomas and Maier, Hans Jürgen}}, issn = {{2397-2106}}, journal = {{npj Materials Degradation}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Corrosion fatigue behavior of nanoparticle modified iron processed by electron powder bed fusion}}}, doi = {{10.1038/s41529-024-00470-w}}, volume = {{8}}, year = {{2024}}, } @article{62255, abstract = {{AbstractCellular stress and ageing involve an increase in crowding and aggregation of amylogenic proteins. We here investigate if crowding is the intrinsic cause of aggregation and utilise a previously established non-protein aggregation sensor, namely pseudoisocyanine chloride (PIC). PIC shows fibrillization in cells into a highly fluorescent J-aggregated state and is sensitive to crowding. Surprisingly, cell stress conditions stabilise the monomeric rather than the aggregated state of PIC both in the cytoplasm and in stress granules. Regarding the different physiochemical changes of the cytoplasm occurring upon cell stress, involving volume reduction, phase separation and solidification, the intrinsic crowding effect is not the key factor to drive associated self-assembly processes.}}, author = {{Pollak, Roland and Koch, Leon and König, Benedikt and Ribeiro, Sara S. and Samanta, Nirnay and Huber, Klaus and Ebbinghaus, Simon}}, issn = {{2399-3669}}, journal = {{Communications Chemistry}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Cell stress and phase separation stabilize the monomeric state of pseudoisocyanine chloride employed as a self-assembly crowding sensor}}}, doi = {{10.1038/s42004-024-01315-y}}, volume = {{7}}, year = {{2024}}, } @article{62252, author = {{Alfano, Caterina and Fichou, Yann and Huber, Klaus and Weiss, Matthias and Spruijt, Evan and Ebbinghaus, Simon and De Luca, Giuseppe and Morando, Maria Agnese and Vetri, Valeria and Temussi, Piero Andrea and Pastore, Annalisa}}, issn = {{0009-2665}}, journal = {{Chemical Reviews}}, number = {{6}}, pages = {{3186--3219}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Molecular Crowding: The History and Development of a Scientific Paradigm}}}, doi = {{10.1021/acs.chemrev.3c00615}}, volume = {{124}}, year = {{2024}}, } @article{62251, author = {{Müller, Wenke and Sroka, Weronika and Schweins, Ralf and Nöcker, Bernd and Poon, Jia-Fei and Huber, Klaus}}, issn = {{0743-7463}}, journal = {{Langmuir}}, number = {{17}}, pages = {{8872--8885}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Impact of Additive Hydrophilicity on Mixed Dye-Nonionic Surfactant Micelles: Micelle Morphology and Dye Localization}}}, doi = {{10.1021/acs.langmuir.4c00012}}, volume = {{40}}, year = {{2024}}, }