@article{60973, abstract = {{The specific binding of DNA origami nanostructures (DONs) to bacteria is an important prerequisite for their application in pathogen targeting and antimicrobial drug delivery. So far, targeting bacteria with DONs has been achieved exclusively via aptamers, which suffer from drawbacks such as sensitivity toward environmental conditions and reduced binding after immobilization or conjugation. Here, an alternative approach is presented based on the modification of DONs with the cell wall‐binding glycopeptide antibiotic vancomycin. Using strain‐promoted azide‐alkyne cycloaddition, azide‐modified vancomycin is conjugated to selected staple strands and subsequently incorporated into 2D DON triangles. The resulting constructs show specific binding to the Gram‐positive species Bacillus subtilis (B. subtilis) and Staphylococcus capitis (S. capitis), and remarkably, to Gram‐negative Escherichia coli (E. coli), but no antimicrobial activity at vancomycin concentrations up to at least 2.91 μM. For B. subtilis and E. coli, DONs with vancomycin modifications on both sides exhibit better binding than DONs modified on only one side. However, both variants bind equally well to S. capitis. These results demonstrate the great potential of small molecule drug compounds for the robust, broad‐spectrum targeting of bacteria with DONs. Targeting a ubiquitous cell wall component of most pathogenic bacteria, vancomycin‐modified DONs have many potential applications in the prevention and treatment of nosocomial infections.}}, author = {{Coşkuner Leineweber, Özge and Pothineni, Bhanu K. and Schumann, Nils and Hofmann, Ulrike and Möser, Christin and Smith, David M. and Grundmeier, Guido and Zhang, Yixin and Keller, Adrian}}, issn = {{2688-4062}}, journal = {{Small Structures}}, publisher = {{Wiley}}, title = {{{Vancomycin‐Modified DNA Origami Nanostructures for Targeting Bacterial Pathogens}}}, doi = {{10.1002/sstr.202500246}}, year = {{2025}}, } @article{61015, author = {{Baier, Dominik and Kieke, Laureen and Voth, Sven and Kloß, Marvin and Huck, Marten and Steinrück, Hans-Georg and Tiemann, Michael}}, issn = {{2379-3694}}, journal = {{ACS Sensors}}, number = {{8}}, pages = {{5664--5673}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Selective H2 Gas Sensing Using ZIF-71/In-SnO2 Bilayer Sensors: A Size-Selective Molecular Sieving Approach}}}, doi = {{10.1021/acssensors.5c00770}}, volume = {{10}}, year = {{2025}}, } @article{61821, abstract = {{AbstractControlling the surface orientation of DNA origami nanostructures (DON) is crucial for applications in nanotechnology and materials science. While previous work utilized various DON modifications, simple methods for controlling their landing orientation remain scarce. Here, we demonstrate a straightforward approach to control the adsorption orientation of chiral double‐L (CDL) DON on mica by tuning magnesium ion (Mg2⁺) concentration and exploiting global shape distortions. Using atomic force microscopy (AFM), we analyzed the resulting distribution of the mirror‐image orientations, referred to as S and Z orientations, at both buffer/mica and air/mica interfaces and identified conditions resulting in homogenous CDL orientation of 100% S. These results demonstrate how DON conformation and ionic environments influence DON orientation, offering insights for precise nanostructure deposition.}}, author = {{Velpula, Gangamallaiah and Tomm, Emilia and Shen, Boxuan and Mali, Kunal S. and Keller, Adrian Clemens and De Feyter, Steven}}, issn = {{1433-7851}}, journal = {{Angewandte Chemie International Edition}}, publisher = {{Wiley}}, title = {{{Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate}}}, doi = {{10.1002/anie.202507613}}, year = {{2025}}, } @article{62087, abstract = {{AbstractHighlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch von Furanen zu Pyrrolen; mit Ammoniak zu primären Arylaminen; Metallschrott recyceln mit ionischen Flüssigkeiten; terminale Alkene mit Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente und Alkaloide.}}, author = {{Breugst, Martin and Andexer, Jennifer and Barra, Lena and Beil, Sebastian B. and Bierbach, Sascha and Burkhardt, Immo and Dumele, Oliver and Ernst, Martin and Frommer, Jennifer and Gellrich, Urs and Germer, Philipp and Giese, Michael and Huy, Peter and Klepp, Julian and Körber, Karsten and Kordes, Markus and Kuttruff, Christian A. and Lindel, Thomas and Pfrengle, Fabian and Pieber, Bartholomäus and Pietruszka, Jörg and Schaschke, Norbert and Senge, Mathias O. and Stadler, Nina and Storch, Golo and Teichert, Johannes F. and Waldvogel, Siegfried R. and Werner, Thomas and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{40--70}}, publisher = {{Wiley}}, title = {{{Trendbericht: Organische Chemie 2025}}}, doi = {{10.1002/nadc.20254147860}}, volume = {{73}}, year = {{2025}}, } @article{61335, abstract = {{Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus, efficient strategies for their preparation are in great demand. Herein, a novel protocol is reported for the synthesis of amidines based on PIII/PVO redox catalysis. This two‐step, one‐pot approach involves the activation of amides via PIII/PVO catalyzed in situ formation of imidoyl chloride intermediates which are directly converted upon reaction with amines into the corresponding amidines. Instead of traditionally used toxic and corrosive chloride sources, hexachloroacetone (HCA) is successfully employed as a halide source. The reaction proceeds with low catalyst loading (2 mol%) in BuOAc as the solvent. Under the optimized conditions, 20 amidines are prepared in yields up to 99%. A feasible mechanism is proposed based on experimental results. The synthetic potential of this method is evaluated in the preparation of the tyrosine kinase inhibitor (TKI) Erlotinib.}}, author = {{Medvaric, Viktorija and Paradies, Jan and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T2, T, CSSD}}, publisher = {{Wiley}}, title = {{{Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides}}}, doi = {{10.1002/adsc.70059}}, year = {{2025}}, } @article{62086, author = {{Stefanow, Vivian and Kell, Lukas and Leduskrasta, Aiga and Eh, Marcus and Panten, Johannes and Werner, Thomas}}, issn = {{0022-3263}}, journal = {{The Journal of Organic Chemistry}}, keywords = {{T4, CSSD}}, number = {{37}}, pages = {{12877--12887}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Straightforward Access to Terpene-Based 1,2-Diols and Their Acetals as Fragrance Ingredients}}}, doi = {{10.1021/acs.joc.5c00889}}, volume = {{90}}, year = {{2025}}, } @article{61336, author = {{Zhou, Rundong and Medvaric, Viktorija and Werner, Thomas and Paradies, Jan}}, issn = {{0002-7863}}, journal = {{Journal of the American Chemical Society}}, keywords = {{T2, CSSD}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Metal-Free Reduction of Nitrous Oxide via PIII/PV═O Cycling: Mechanistic Insights and Catalytic Performance}}}, doi = {{10.1021/jacs.5c06190}}, year = {{2025}}, } @article{62190, abstract = {{AbstractLignin, a widely available and renewable organic polymer, has several desirable properties and applications. However, as a by‐product of pulp and paper industry, it is mainly burned for energy. Limited understanding of the complex and heterogeneous structure and a shortage of tailored analysis methods hinder its utilization in higher value applications. This study describes and compares the use of two different static light scattering methods, laser diffraction and small‐angle light scattering (SALS), for studying lignin particle size in suspension. The results from laser diffraction showed that the selected particle concentration and absorption coefficient affect the measured sizes especially for particles <1 µm in diameter. For irregularly shaped particles with broad size distributions, sampling is the most important parameter affecting the results. SALS proved an efficient method for obtaining information on particle aggregation by providing primary particle sizes as well as aggregate sizes. Characterization of samples with spherical particles and narrow size distributions is straightforward with both laser diffraction and SALS, whereas the interpretation of results for more heterogeneous samples is less obvious. Static light scattering methods could make lignin particle size analysis more rapid and automated, thus enhancing lignin valorization, but should be applied carefully to avoid systematic errors.}}, author = {{Makkonen, Janita and Ahvenainen, Patrik and Bertella, Stefania and Kellock, Miriam and Saha, Sanjib and Huber, Klaus and Farooq, Muhammad and Österberg, Monika and Penttilä, Paavo}}, issn = {{0934-0866}}, journal = {{Particle & Particle Systems Characterization}}, publisher = {{Wiley}}, title = {{{Static Light Scattering for Lignin Particle Size Characterization}}}, doi = {{10.1002/ppsc.202500085}}, year = {{2025}}, } @article{62180, author = {{Koch, Leon and Rajput, Satyendra and Richter, Antonio and König, Benedikt and Nayar, Divya and Ebbinghaus, Simon and Huber, Klaus}}, issn = {{1520-6106}}, journal = {{The Journal of Physical Chemistry B}}, number = {{25}}, pages = {{6115--6126}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Self-Assembly of Pseudo Isocyanine Chloride in the Presence of Attractive Polyethylene Glycol Crowders}}}, doi = {{10.1021/acs.jpcb.4c06843}}, volume = {{129}}, year = {{2025}}, } @article{62189, author = {{Kollmann, Fabian and Büngeler, Anne and Splett, Miriam and Strube, Oliver I. and Huber, Klaus}}, issn = {{1525-7797}}, journal = {{Biomacromolecules}}, number = {{5}}, pages = {{3104--3112}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Analysis of the Growth Mechanism of Eumelanin Particles by Time-Resolved Static and Dynamic Light Scattering}}}, doi = {{10.1021/acs.biomac.5c00158}}, volume = {{26}}, year = {{2025}}, } @article{62177, author = {{Huber, Klaus and Martens, C.M. and Tuinier, R.}}, issn = {{0021-9797}}, journal = {{Journal of Colloid and Interface Science}}, publisher = {{Elsevier BV}}, title = {{{Coil dimensions of macromolecules in the presence of crowding colloids: Impact of crowder size}}}, doi = {{10.1016/j.jcis.2025.137340}}, volume = {{691}}, year = {{2025}}, } @article{62798, abstract = {{We investigated electrodeposited nanoparticulate nickel selenide (pre)catalysts that transform into nickel oxides/oxyhydroxides under oxygen evolution reaction conditions in alkaline solutions. Previous studies of this transformation were conducted at lower current densities than those of industrial relevance (≥1 A cm–2). We used ultramicroelectrodes (UMEs) to achieve such current densities, benefiting from their small size, ensuring low absolute currents and low ohmic drop but high current densities. Morphological degradation of the catalyst material was only observed at current densities exceeding 1 A cm–2 but not for smaller ones. Using X-ray absorption, X-ray photoemission spectroscopy, and X-ray diffraction, we confirmed that the degradation was accompanied by the literature-known transformation of nanoparticulate Ni3Se2 (bulk)/NiSe (surface) into nickel oxyhydroxide. The transformation of the precatalyst goes along with a significant improvement in the charge transfer kinetics observed by decreasing Tafel slopes with ongoing experimental time extracted from cyclic voltammetry (CV) experiments and electrochemical impedance spectroscopy (EIS) in the high-frequency range. However, these kinetic improvements are accompanied by limitations in mass transport concluded from decreasing current responses at high overpotentials in CVs and increasing impedance in the low-frequency range of the EIS spectra after extended CV cycling. These mass transport limitations originated from morphological degradations at the UME exceeding 1 A cm–2 which we proved by applying identical location scanning electron microscopy. This has not been reported in studies that have been limited to lower current densities before. Our findings showcase how UMEs can be used to study (pre)catalysts (herein nickel selenides) under current densities of industrial relevance in the absence of ohmic drop-related ambiguities, combined with in-depth materials characterization studies, e.g., identical location microscopy and advanced spectroscopic methods. This approach enables direct evaluation and comparison of catalyst materials and thus demonstrates how to overcome long-standing limitations of electrocatalyst design and testing.}}, author = {{Hiege, Felix and Chang, Chun-Wai and Trost, Oliver and van Halteren, Charlotte E. R. and Hosseini, Pouya and Bendt, Georg and Schulz, Stephan and Feng, Zhenxing and Linnemann, Julia and Tschulik, Kristina}}, issn = {{1944-8244}}, journal = {{ACS Applied Materials & Interfaces}}, keywords = {{Electrocatalysis, oxygen evolution reaction, nickel selenide, microelectrode}}, number = {{29}}, pages = {{41893--41903}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Morphological Degradation of Oxygen Evolution Reaction-Electrocatalyzing Nickel Selenides at Industrially Relevant Current Densities}}}, doi = {{10.1021/acsami.5c05381}}, volume = {{17}}, year = {{2025}}, } @article{62819, abstract = {{Novel oxalate-bridged heterotrinuclear complexes [A][Mn2Cr(bpy)2(H2O)2Cl2(C2O4)3] (A = (CH3)2(C2H5)NH+ (1) and (CH3)(C2H5)2NH+ (2); bpy = 2,2′-bipyridine) were synthesized using an aqueous solution of [A]3[Cr(C2O4)3] as a building block in reaction with Mn2+ ions and with the addition of the N-donor ligand bipyridine. The isostructural heterometallic complex salts were characterized by single-crystal and powder X-ray diffraction, infrared and impedance spectroscopy, thermal analysis and magnetization measurements. The trinuclear anion [{Mn(bpy)(H2O)Cl(μ-C2O4)}2Cr(C2O4)]− consists of two [Mn(bpy)(H2O)Cl]+ units bridged by the [Cr(C2O4)3]3− anion, which acts as a bidentate ligand towards each of the manganese atoms. The anions are hydrogen bonded to each other via coordinated chloride anions, water molecules and oxygen oxalate atoms, resulting in two-dimensional (2D) hydrogen bonding layers. Compounds exhibit water-assisted proton conductivity behaviour, which was investigated at different temperatures and relative humidities (RH). At 25 °C, an increase in RH from 60% to 93% resulted in an obvious proton conducting switch from 9.1 × 10−11 to 5.6 × 10−5 S cm−1 for 1 and from 7.4 × 10−10 to 1.8 × 10−6 S cm−1 for 2, corresponding to high on/off ratios of about 106 for 1 and 104 for 2. In situ powder X-ray diffraction (PXRD) analysis showed that unit cell parameters of compounds 1 and 2 slightly increase when exposed to humid conditions. This confirmed that incorporation of water molecules into structures with pores and voids causes the proton conductivity switching phenomenon. Magnetic susceptibility measurements indicate a ferromagnetic interaction between Cr3+ and Mn2+ ions bridged by the bis(bidentate) oxalate group. The prepared compounds 1 and 2 were explored as single-source precursors for the formation of spinel oxide by their thermal treatment. With increasing temperature, the spinel composition changed according to the formula Mn1+xCr2–xO4 (0 ≤ x ≤ 1), where x = 0.7 at 500 °C and x = 1 at 900 °C when tet[MnII]oct[MnIIICrIII]O4 is formed. The (micro)structure, morphology, and optical properties of spinel Mn2CrO4 were characterized by PXRD, scanning electron microscopy and UV-Vis diffuse reflectance spectroscopy. The photocatalytic activity of this oxide in degradation of the methylene blue dye under Vis irradiation without and with the support of hydrogen peroxide was further investigated.}}, author = {{Lozančić, Ana and Burazer, Sanja and Wagner, Tobias and Molčanov, Krešimir and Pajić, Damir and Androš Dubraja, Lidija and Tiemann, Michael and Jurić, Marijana}}, issn = {{2050-7526}}, journal = {{Journal of Materials Chemistry C}}, number = {{41}}, pages = {{21179--21195}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Water-assisted proton conductivity and a magnetic study of heterotrinuclear oxalate-bridged compounds: molecular precursors for the Mn2CrO4 spinel}}}, doi = {{10.1039/d5tc02569a}}, volume = {{13}}, year = {{2025}}, } @article{62816, abstract = {{The increasing demand for advanced sensing technologies drives the development of chemical sensors using innovative materials. In gas sensing, optical sensors are often used to detect gases such as CO, NOx, and O2. Oxygen sensors typically incorporate dyes into oxygen-permeable matrices like polymers, silica, or zeolites. Alternatively, semiconductor surface chemistry can enable O2 detection. However, these approaches are often limited by slow response and recovery times and low selectivity, restricting their practical applications. The metal-organic framework MOF-76(Eu) and its yttrium-modified variant, MOF-76(Eu/Y) are reported to exhibit highly reversible and fast optical responses to varying O2 concentrations. Time-resolved emission measurements are performed over short (seconds) and long (hours) timescales using N2 and synthetic air mixtures. Cross-sensitivity to humidity is analyzed. Multichannel scaling photon-counting experiments confirm quenching at the linker level, as the emission lifetime remains nearly constant. Yttrium significantly improves stability and performance at room temperature. Structural and optical changes induced by yttrium are investigated. Additionally, MIL-78(Eu), another Eu-BTC-based MOF with a different coordination environment, is synthesized. Unlike MOF-76(Eu), MIL-78(Eu) exhibits distinct optical properties but lacks a reversible response to O2. These results highlight the potential of MOF-76-based materials for high-performance O2 sensing.}}, author = {{Zhao, Zhenyu and Weinberger, Christian and Steube, Jakob and Bauer, Matthias and Brehm, Martin and Tiemann, Michael}}, issn = {{1616-301X}}, journal = {{Advanced Functional Materials}}, publisher = {{Wiley}}, title = {{{Fast‐Responding O2 Gas Sensor Based on Luminescent Europium Metal‐Organic Frameworks (MOF‐76)}}}, doi = {{10.1002/adfm.202511190}}, year = {{2025}}, } @inproceedings{60637, author = {{Weiser, David and Ditter, Rebecca and Ditter, David and Siepmann, Karin and Grandrath, Rebecca and Fechner, Sabine and Sommer, Katrin and Bohrmann-Linde, Claudia and Rubner, Isabel}}, booktitle = {{International conference New Perspective on Science Education}}, isbn = {{979-12-80225-83-2}}, location = {{Florence}}, number = {{14}}, publisher = {{Libreriauniversitaria.it}}, title = {{{Innovative teaching with actionbound: Digital pathways in chemistry education - a practical example from ComeNet Chemistry in the ComeMINT Project}}}, year = {{2025}}, } @inbook{61474, author = {{Habig, Sebastian and Großmann, Nadine and Schmid, Andrea M. and van Vorst, Helena and Fechner, Sabine and Wilde, Matthias}}, booktitle = {{Interesse revisited}}, isbn = {{9783658485412}}, publisher = {{Springer Fachmedien Wiesbaden}}, title = {{{Empirische Befunde der Interessenforschung der Fächer Biologie, Chemie und Physik im Primar- und Sekundarbereich seit 2012 – Ein systematisches Review}}}, doi = {{10.1007/978-3-658-48542-9_4}}, year = {{2025}}, } @inbook{61475, author = {{Zöchling, Sarah and Pletschacher, Laura and Maurer, Christian and Berger, Roland and Lindmaier, Kerstin and Fechner, Sabine and Wodzinski, Rita}}, booktitle = {{Interesse revisited}}, isbn = {{9783658485412}}, publisher = {{Springer Fachmedien Wiesbaden}}, title = {{{Interessenförderung im Physik- und Chemieunterricht – Eine Bestandsaufnahme}}}, doi = {{10.1007/978-3-658-48542-9_10}}, year = {{2025}}, } @article{62876, abstract = {{ABSTRACT Spin‐coated polylactide (PLA) thin films were exposed to nitrogen plasma for varying time intervals. The progressive etching of the PLA film in direct contact with the nitrogen plasma was monitored in situ using polarization modulated infrared reflection absorption spectroscopy (PM‐IRRAS). No appreciative changes in composition were seen with PM‐IRRAS, indicating that the etching did not significantly affect the bulk composition. Atomic force microscopy characterization of the plasma‐etched films showed that the PLA films are homogeneously etched. Subsequent ex situ XPS analysis of the treated surface revealed the presence of C‐N bonds in the surface‐near region that could be associated with amino and/or amide surface species. PLA films were also alternatively exposed to nitrogen ion beams produced by an electron‐cyclotron‐resonance (ECR) plasma source and were investigated in vacuo by XPS. This treatment revealed the partial substitution of surface oxygen species by nitrogen, resulting in a similar surface modification as in the plasma case. The comparison of XPS data and water contact angle studies suggest that the activated surfaces show a reorientation of macromolecular fragments in the surface‐near region depending on the polarity of the phase with which they are in contact. Under ultra‐high vacuum (UHV) conditions, the surface tends to lower its surface energy, while in contact with the aqueous phase, subsurface polar groups orientate outwards, which enables the formation of hydrogen bonds.}}, author = {{Gołębiowska, Sandra and Voigt, Markus and de los Arcos de Pedro, Maria Teresa and Grundmeier, Guido}}, issn = {{0142-2421}}, journal = {{Surface and Interface Analysis}}, number = {{7}}, pages = {{499--509}}, publisher = {{Wiley}}, title = {{{In Situ PM‐IRRAS and XPS Analysis of Nitrogen Plasma Surface Modification of Polylactide Thin Films}}}, doi = {{10.1002/sia.7406}}, volume = {{57}}, year = {{2025}}, } @article{62875, author = {{Theile-Rasche, Chantal and Wang, Fuzeng and Prüßner, Tim and Huck, Marten and Steinrück, Hans-Georg and de los Arcos de Pedro, Maria Teresa and Grundmeier, Guido}}, issn = {{0040-6090}}, journal = {{Thin Solid Films}}, publisher = {{Elsevier BV}}, title = {{{Evaluation of anti-adhesive and corrosion protection properties of TiAlSiN-magnetron-sputtered films for applications in polymer processing}}}, doi = {{10.1016/j.tsf.2025.140676}}, volume = {{820}}, year = {{2025}}, } @article{62874, abstract = {{DNA origami adsorption at single-crystalline TiO2 surfaces is investigated at different Mg2+ concentrations. For TiO2(001), DNA origami adsorption is stronger at 5 mM than at 10 mM Mg2+, whereas the opposite is observed for TiO2(110) and TiO2(111).}}, author = {{Xu, Xiaodan and Gołębiowska, Sandra and de los Arcos de Pedro, Maria Teresa and Grundmeier, Guido and Keller, Adrian}}, issn = {{2755-3701}}, journal = {{RSC Applied Interfaces}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{DNA origami adsorption at single-crystalline TiO2 surfaces}}}, doi = {{10.1039/d5lf00109a}}, year = {{2025}}, }