@article{27078, abstract = {{Adequate dietary habits are supposed to be one of the most important modifiable factors in osteoporosis prevention. However, the importance of specific nutrients is controversial. We examined relevant nutrients which are supposed to have an impact on bone parameters and compared their effect sizes with those of two known predictors of bone development: bone-related muscle mass and androgen levels. We analysed nutritional, hormonal and anthropometric data from 107 prepubertal children participating in the Dortmund Nutritional and Anthropometric Longitudinally Designed Study. Diaphyseal bone mineral content (BMC), cortical area (CA), periosteal circumference, strength strain index and muscle area of the non-dominant forearm were measured by peripheral quantitative computed tomography. Data on long-term nutrient intakes (e.g. protein, Ca and vitamin D) were derived from 3 d weighed dietary records. Twenty-four hour urinary excretion rates of androgen metabolites including the sex steroid androstenediol were measured using GC–MS. Of all considered nutrients, only protein showed a trend for an association with BMC (β = +0·11; P = 0·073) and CA (β = +0·11; P = 0·056) in stepwise linear regression models. None of the other considered dietary variables was associated with bone parameters. The size of the bone anabolic effect of protein was partly comparable with that of androstenediol. Even though boys gained more bone mass in comparison with girls, the protein effect did not differ between sexes. Bone-related muscle area and sex steroids have the strongest effects on prepubertal diaphyseal bone. However, dietary protein may have a similar bone anabolic influence compared with androstenediol. In children without explicit nutrient deficits, protein seems to be the most important dietary component for diaphyseal bone status.}}, author = {{Libuda, Lars and Wudy, Stefan A. and Schoenau, Eckhard and Remer, Thomas}}, issn = {{0007-1145}}, journal = {{British Journal of Nutrition}}, pages = {{428--435}}, title = {{{Comparison of the effects of dietary protein, androstenediol and forearm muscle area on radial bone variables in healthy prepubertal children}}}, doi = {{10.1017/s0007114510003508}}, year = {{2010}}, } @article{27079, author = {{Johner, S A and Libuda, Lars and Shi, L and Retzlaff, A and Joslowski, G and Remer, T}}, issn = {{0954-3007}}, journal = {{European Journal of Clinical Nutrition}}, pages = {{1365--1370}}, title = {{{Urinary fructose: a potential biomarker for dietary fructose intake in children}}}, doi = {{10.1038/ejcn.2010.160}}, year = {{2010}}, } @article{27131, author = {{Diethelm, Katharina and Libuda, Lars and Bolzenius, Katja and Griefahn, Barbara and Buyken, Anette and Remer, Thomas}}, issn = {{1663-2826}}, journal = {{Hormone Research in Paediatrics}}, pages = {{390--398}}, title = {{{Longitudinal Associations between Endogenous Melatonin Production and Reported Sleep Duration from Childhood to Early Adulthood}}}, doi = {{10.1159/000303134}}, year = {{2010}}, } @inbook{27590, author = {{Remer, T. and Libuda, Lars}}, booktitle = {{Nutritional Influences on Bone Health. }}, isbn = {{978-1-84882-977-0}}, publisher = {{Springer}}, title = {{{Bone-anabolic impact of dietary high protein intake compared with effects of low potential renal acid load, endogenous steroid hormones, and muscularity in children. }}}, year = {{2010}}, } @article{27723, author = {{Remer, Thomas and Shi, Lijie and Buyken, Anette and Maser-Gluth, Christiane and Hartmann, Michaela F. and Wudy, Stefan A.}}, issn = {{0021-972X}}, journal = {{The Journal of Clinical Endocrinology & Metabolism}}, pages = {{3002--3009}}, title = {{{Prepubertal Adrenarchal Androgens and Animal Protein Intake Independently and Differentially Influence Pubertal Timing}}}, doi = {{10.1210/jc.2009-2583}}, year = {{2010}}, } @article{27725, abstract = {{ Whether prepubertal estrogen production impacts on the timing of puberty is not clear. We aimed to investigate prepubertal 24-h estrogen excretion levels and their association with early and late pubertal markers. Daily urinary excretion rates of estrogens of 132 healthy children, who provided 24-h urine samples 1 and 2 yr before the start of the pubertal growth spurt [age at takeoff (ATO)], were quantified by stable isotope dilution/GC-MS. E-sum3 (estrone + estradiol + estriol) was used as a marker for potentially bioactive estrogen metabolites and E-sum5 (E-sum3 + 16-epiestriol + 16-ketoestradiol) for total estrogen production. Pubertal outcomes were ATO, age at peak height velocity (APHV), duration of pubertal growth acceleration (APHV-ATO), age at Tanner stage 2 for pubic hair (PH2), genital (G2, boys) and breast (B2, girls) development, and age at menarche. Prepubertal urinary estrogen excretions (E-sum3 and E-sum5) were not associated with ATO, APHV, and age at PH2 but with duration of pubertal growth acceleration ( P < 0.01) in both sexes. Girls with higher E-sum3 reached B2 0.9 yr ( P = 0.04) and menarche 0.3 yr earlier ( P = 0.04) than girls with lower E-sum3. E-sum3 was not associated with age at G2 in boys ( P = 0.6). For most pubertal variables, the associations with E-sum3 were stronger than with E-sum5. In conclusion, prepubertal estrogens may not be critical for the onset of the pubertal growth spurt but are correlated with its duration in both boys and girls. Prepubertal estrogen levels may already predict the timing of girls' menstruation and breast development but do not appear to affect sexual maturation in boys. }}, author = {{Shi, Lijie and Remer, Thomas and Buyken, Anette and Hartmann, Michaela F. and Hoffmann, Philipp and Wudy, Stefan A.}}, issn = {{0193-1849}}, journal = {{American Journal of Physiology-Endocrinology and Metabolism}}, pages = {{E990--E997}}, title = {{{Prepubertal urinary estrogen excretion and its relationship with pubertal timing}}}, doi = {{10.1152/ajpendo.00374.2010}}, year = {{2010}}, } @article{27726, author = {{Buyken, Anette and Bolzenius, Katja and Karaolis-Danckert, Nadina and Günther, Anke L.B. and Kroke, Anja}}, issn = {{1042-0533}}, journal = {{American Journal of Human Biology}}, pages = {{216--224}}, title = {{{Body composition trajectories into adolescence according to age at pubertal growth spurt}}}, doi = {{10.1002/ajhb.21125}}, year = {{2010}}, } @article{27780, author = {{Buyken, Anette and Mitchell, P. and Ceriello, A. and Brand-Miller, J.}}, issn = {{0012-186X}}, journal = {{Diabetologia}}, pages = {{406--418}}, title = {{{Optimal dietary approaches for prevention of type 2 diabetes: a life-course perspective}}}, doi = {{10.1007/s00125-009-1629-8}}, year = {{2010}}, } @article{27781, author = {{Degen, Gisela H. and Blaszkewicz, Meinolf and Shi, Lijie and Buyken, Anette and Remer, Thomas}}, issn = {{1613-4125}}, journal = {{Molecular Nutrition & Food Research}}, pages = {{359--367}}, title = {{{Urinary isoflavone phytoestrogens in German children and adolescents - A longitudinal examination in the DONALD cohort}}}, doi = {{10.1002/mnfr.201000325}}, year = {{2010}}, } @inbook{36036, author = {{Schlegel-Matthies, Kirsten}}, booktitle = {{Auf dem Weg zum Jugendintegrationskonzept. Grundlagen und Herausforderungen angesichts veränderter Lebenslagen junger Menschen}}, editor = {{Müller, Christine and Schulz, Franziska and Thien, Ulrich}}, isbn = {{9783643105103}}, pages = {{247 -- 250}}, publisher = {{Lit-Verlag}}, title = {{{Überschuldung - Bildungsbezogene Perspektive}}}, year = {{2010}}, } @article{54942, abstract = {{Loss-of-function mutations of the epithelial sodium channel (ENaC) may contribute to pulmonary symptoms resembling those of patients with atypical cystic fibrosis (CF). Recently, we identified a loss-of-function mutation in the alpha-subunit of ENaC (alphaF61L) in an atypical CF patient without mutations in CFTR. To investigate the functional effect of this mutation, we expressed human wild-type alpha beta gamma-ENaC or mutant alpha(F61L) beta gamma-ENaC in Xenopus laevis oocytes. The alphaF61L mutation reduced the ENaC mediated whole-cell currents by approximately 90%. In contrast, the mutation decreased channel surface expression only by approximately 40% and did not alter the single-channel conductance. These findings indicate that the major effect of the mutation is a reduction of the average channel open probability (P(o)). This was confirmed by experiments using the betaS520C mutant ENaC which can be converted to a channel with a P(o) of nearly one, and by experiments using chymotrypsin to proteolytically activate the channel. These experiments revealed that the mutation reduced the average P(o) of ENaC by approximately 75%. Na(+) self inhibition of the mutant channel was significantly enhanced, but the observed effect was too small to account for the large reduction in average channel P(o). The ENaC-activator S3969 partially rescued the loss-of-function phenotype of the alphaF61L mutation. We conclude that the alphaF61L mutation may contribute to respiratory symptoms in atypical CF patients.}}, author = {{Huber, Regina and Krueger, Bettina and Diakov, Alexei and Korbmacher, Judit and Haerteis, Silke and Einsiedel, Jürgen and Gmeiner, Peter and Azad, Abul and Cuppens, Harry and Cassiman, Jean-Jaques and Korbmacher, Christoph and Rauh, Robert}}, journal = {{Cellular Physiology and Biochemistry}}, number = {{001}}, pages = {{145–158}}, publisher = {{S. Karger AG}}, title = {{{Functional Characterization of a Partial Loss-of-Function Mutation of the Epithelial Sodium Channel (ENaC) Associated with Atypical Cystic Fibrosis}}}, doi = {{10.1159/000272059}}, volume = {{25}}, year = {{2010}}, } @article{27886, author = {{Bigga, Regine and Schlegel-Matthies, Kirsten}}, journal = {{Haushalt & Bildung}}, number = {{3}}, pages = {{48--57}}, title = {{{Verbraucherbildung und Konsum – Was wissen Studierende? – Überlegungen zur Hochschuldidaktik}}}, volume = {{87}}, year = {{2010}}, } @article{26893, author = {{Shi, Lijie and Wudy, Stefan A and Buyken, Anette and Hartmann, Michaela F and Remer, Thomas}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, pages = {{1321--1328}}, title = {{{Body fat and animal protein intakes are associated with adrenal androgen secretion in children}}}, doi = {{10.3945/ajcn.2009.27964}}, year = {{2009}}, } @article{26894, author = {{Karaolis-Danckert, Nadina and Buyken, Anette and Sonntag, Antje and Kroke, Anja}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, pages = {{1559--1565}}, title = {{{Birth and early life influences on the timing of puberty onset: results from the DONALD (DOrtmund Nutritional and Anthropometric Longitudinally Designed) Study}}}, doi = {{10.3945/ajcn.2009.28259}}, year = {{2009}}, } @article{26895, author = {{Cheng, Guo and Gerlach, Steffi and Libuda, Lars and Kranz, Sibylle and Günther, Anke L. B. and Karaolis-Danckert, Nadina and Kroke, Anja and Buyken, Anette}}, issn = {{1541-6100}}, journal = {{The Journal of Nutrition}}, pages = {{95--102}}, title = {{{Diet Quality in Childhood Is Prospectively Associated with the Timing of Puberty but Not with Body Composition at Puberty Onset}}}, doi = {{10.3945/jn.109.113365}}, year = {{2009}}, } @article{26896, author = {{Günther, Anke L. B. and Karaolis-Danckert, Nadina and Kroke, Anja and Remer, Thomas and Buyken, Anette}}, issn = {{1541-6100}}, journal = {{The Journal of Nutrition}}, pages = {{565--571}}, title = {{{Dietary Protein Intake throughout Childhood Is Associated with the Timing of Puberty}}}, doi = {{10.3945/jn.109.114934}}, year = {{2009}}, } @article{27008, author = {{Buyken, Anette and Flood, Victoria and Rochtchina, Elena and Nestel, Paul and Brand-Miller, Jennie and Mitchell, Paul}}, issn = {{1541-6100}}, journal = {{The Journal of Nutrition}}, pages = {{88--94}}, title = {{{Modifications in Dietary Fat Quality Are Associated with Changes in Serum Lipids of Older Adults Independently of Lipid Medication}}}, doi = {{10.3945/jn.109.110486}}, year = {{2009}}, } @article{27080, author = {{Muckelbauer, Rebecca and Libuda, Lars and Clausen, Kerstin and Toschke, André M. and Reinehr, Thomas and Kersting, Mathilde}}, issn = {{1930-7381}}, journal = {{Obesity}}, pages = {{528--534}}, title = {{{Immigrational Background Affects the Effectiveness of a School-based Overweight Prevention Program Promoting Water Consumption}}}, doi = {{10.1038/oby.2009.270}}, year = {{2009}}, } @article{27132, abstract = {{AbstractObjectiveDrinking habits in children are associated with diet quality, but validated assessment tools for large-scale studies in young children are lacking. Therefore, we validated a self-completion 24 h recall questionnaire (RQ) focusing on beverage consumption with a 24 h weighed record (WR).DesignThirty-five voluntary participants from the DONALD (Dortmund Nutritional and Anthropometric Longitudinally Designed) Study cohort aged 7–9 years completed the RQ. The illustrated RQ required ticking the number of glasses of seven beverage categories consumed in five time intervals in the previous 24 h. As a reference, parents completed weighed records of their child’s diet. Agreement between the RQ and WR was tested by classification into consumers and non-consumers (kappa coefficients, κ), by the children’s ability to estimate the exact beverage and total volume consumed (Wilcoxon signed-rank test, Spearman rank correlation), and by ranking children according to reported beverage volumes.ResultsThe RQ and WR showed a good level of agreement for classifying participants into consumers and non-consumers of the single beverage categories (κ values between 0·78 and 0·94). Correlation coefficients for the volume of the single categories ranged between 0·81 and 0·91. The total beverage volume was overestimated in the RQ, on average, by 114 ml (P = 0·015). Agreement in ranking into tertiles by beverage volume was moderate to good for juice/soft drinks (κ = 0·44), milk (κ = 0·57) and water (κ = 0·70), but fair for the total beverage volume (κ = 0·23).ConclusionsOur self-completion 24 h RQ could estimate the consumption of several beverage categories among young children at the group level, but quantification of total beverage volume was flawed.}}, author = {{Muckelbauer, Rebecca and Libuda, Lars and Kersting, Mathilde}}, issn = {{1368-9800}}, journal = {{Public Health Nutrition}}, pages = {{187--195}}, title = {{{Relative validity of a self-completion 24 h recall questionnaire to assess beverage consumption among schoolchildren aged 7 to 9 years}}}, doi = {{10.1017/s1368980009990759}}, year = {{2009}}, } @article{27133, author = {{Cheng, G. and Karaolis-Danckert, N. and Libuda, Lars and Bolzenius, K. and Remer, T. and Buyken, Anette E.}}, issn = {{0002-9262}}, journal = {{American Journal of Epidemiology}}, pages = {{667--677}}, title = {{{Relation of Dietary Glycemic Index, Glycemic Load, and Fiber and Whole-Grain Intakes During Puberty to the Concurrent Development of Percent Body Fat and Body Mass Index}}}, doi = {{10.1093/aje/kwn375}}, year = {{2009}}, }