@article{27773, author = {{Toeller, M. and Buyken, Anette and Heitkamp, G. and Berg, G. and Scherbaum, W.}}, issn = {{0018-5043}}, journal = {{Hormone and Metabolic Research}}, pages = {{680--685}}, title = {{{Prevalence of Chronic Complications, Metabolic Control and Nutritional Intake in Type 1 Diabetes: Comparison Between Different European Regions}}}, doi = {{10.1055/s-2007-978820}}, year = {{2008}}, } @inbook{27887, author = {{Schlegel-Matthies, Kirsten}}, booktitle = {{Ernährung, Kultur, Lebensqualität. Wege regionaler Nachhaltigkeit}}, editor = {{Antoni-Komar, I. and Pfriem, R. and Raabe, T. and Spiller, A.}}, pages = {{303--315}}, title = {{{Ernährungsbildung in Unterricht und Schulprofil. Essen und Trinken in der Schule – Bildungschance und Beitrag zu sozialer Gerechtigkeit}}}, year = {{2008}}, } @inbook{27888, author = {{Methfessel, B. and Ritterbach, U. and Schlegel-Matthies, Kirsten}}, booktitle = {{.): Schwer messbare Kompetenzen. Herausforderungen für die empirische Fachdidaktik}}, editor = {{Frederking, V.}}, pages = {{115--125}}, title = {{{Private Lebensführung als Umgang mit Komplexität - ein schwer operationalisierbares Bildungsziel}}}, year = {{2008}}, } @article{36070, author = {{Schlegel-Matthies, Kirsten}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{3--5}}, publisher = {{Schneider-Verlag}}, title = {{{Konsumentinnen und Konsumenten - politisch denkende und moralisch handelnde Akteure}}}, volume = {{85}}, year = {{2008}}, } @article{54950, abstract = {{The mechanisms by which proteases activate the epithelial sodium channel (ENaC) are not yet fully understood. We investigated the effect of extracellular proteases on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of trypsin increased ENaC whole-oocyte currents by about 8-fold without a concomitant increase in channel surface expression. The stimulatory effect of trypsin was preserved in oocytes expressing alphagamma-ENaC, but was abolished in oocytes expressing alphabeta-ENaC. Thus, the gamma-subunit appears to be essential for channel activation by extracellular proteases. Site-directed mutagenesis of a putative prostasin cleavage site in the extracellular loop of the gamma-subunit revealed that mutating the 181Lys residue to alanine (gammaK181A) increases ENaC baseline whole-oocyte currents, decreases channel surface expression, and largely reduces the stimulatory effect of extracellular proteases (trypsin, chymotrypsin and human neutrophil elastase). In single-channel recordings from outside-out patches we demonstrated that the gammaK181A mutation essentially abolishes the activation of near-silent channels by trypsin, while a stimulatory effect of trypsin on channel gating is preserved. This apparent dual effect of trypsin on channel gating and on the recruitment of near-silent channels was confirmed by experiments using the beta518C mutant ENaC which can be converted to a channel with an open probability of nearly one by exposure to a sulfhydryl reagent. Interestingly, the gammaK181A mutation results in the spontaneous appearance of a 67 kDa fragment of the gamma-subunit in the plasma membrane which can be prevented by a furin inhibitor and also occurs after channel activation by extracellular trypsin. This suggests that the mutation promotes channel cleavage and activation by endogenous proteases. This would lower the pool of near-silent channels and explain the constitutive activation and reduced responsiveness of the mutant channel to extracellular proteases. We conclude that the mutated site (K181A) affects a region in the gamma-subunit of ENaC that is functionally important for the activation of near-silent channels by extracellular proteases.}}, author = {{Diakov, Alexei and Bera, Katarzyna and Mokrushina, Marianna and Krueger, Bettina and Korbmacher, Christoph}}, journal = {{The Journal of Physiology}}, number = {{19}}, pages = {{4587–4608}}, publisher = {{Wiley}}, title = {{{Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels}}}, doi = {{10.1113/jphysiol.2008.154435}}, volume = {{586}}, year = {{2008}}, } @article{25934, author = {{Günther, AL and Buyken, Anette and Kroke, A}}, issn = {{0002-9165}}, journal = {{Am J Clin Nutr}}, number = {{6}}, pages = {{1626--1633}}, title = {{{Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age.}}}, doi = {{10.1093/ajcn/85.6.1626}}, volume = {{85}}, year = {{2007}}, } @article{25935, author = {{Buyken, Anette and Trauner, K and Günther, AL and Kroke, A and Remer, T}}, issn = {{0002-9165}}, journal = {{Am J Clin Nutr}}, number = {{4}}, pages = {{980--987}}, title = {{{Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children.}}}, doi = {{10.1093/ajcn/86.4.980}}, volume = {{86}}, year = {{2007}}, } @article{25936, author = {{Karaolis-Danckert, N and Günther, AL and Kroke, A and Hornberg, C and Buyken, Anette}}, issn = {{0002-9165}}, journal = {{Am J Clin Nutr}}, number = {{6}}, pages = {{1700--1708}}, title = {{{How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age.}}}, doi = {{10.1093/ajcn/86.5.1700}}, volume = {{86}}, year = {{2007}}, } @article{25937, author = {{Günther, AL and Remer, T and Kroke, A and Buyken, Anette}}, issn = {{0002-9165}}, journal = {{Am J Clin Nutr}}, number = {{6}}, pages = {{1765--1772}}, title = {{{Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age?}}}, doi = {{10.1093/ajcn/86.5.1765}}, volume = {{86}}, year = {{2007}}, } @article{27138, abstract = {{In the present study the relationship between the consumption of different beverage groups and body-weight status in 5 years of study participation in German adolescents was investigated. We used anthropometric and dietary data from 3 d weighed records of 244 subjects between 9 and 18 years of age participating in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study. Only subjects with at least four out of six possible weighed dietary records were considered. A repeated-measures regression model (PROC MIXED) was used to analyse the effect of beverage consumption on body-weight status. BMI standard deviation scores (BMI-SDS) and body fat percentage (%BF) were chosen as the dependent variables. In boys, energetic beverage consumption was not associated with BMI-SDS or %BF, neither cross-sectionally nor prospectively. In girls, baseline consumption of energetic beverages did not predict baseline BMI-SDS, baseline %BF, or change in either variable over the study period. However, an increase in energetic beverage consumption over the study period was associated with an increase in BMI-SDS (+0.070 SDS/MJ increase in energetic beverage consumption; P = 0·01). Separate consideration of regular soft drinks and fruit juices revealed that, in girls, BMI-SDS increased with increased fruit juice consumption (+0·096 SDS/MJ increase in fruit juice consumption; P = 0·01), and to a lesser extent with regular soft drink consumption (+0·055 SDS/MJ increase in regular soft drink consumption; P = 0·08). In conclusion, these results suggest that an increase in energetic beverage consumption may result in weight gain, at least in adolescent girls.}}, author = {{Libuda, Lars and Alexy, Ute and Sichert-Hellert, Wolfgang and Stehle, Peter and Karaolis-Danckert, Nadina and Buyken, Anette and Kersting, Mathilde}}, issn = {{0007-1145}}, journal = {{British Journal of Nutrition}}, pages = {{1370--1379}}, title = {{{Pattern of beverage consumption and long-term association with body-weight status in German adolescents – results from the DONALD study}}}, doi = {{10.1017/s0007114507862362}}, year = {{2007}}, } @article{27588, author = {{Libuda, Lars and Alexey, U.}}, journal = {{Monatsschriften Kinderheilkunde}}, pages = {{684}}, title = {{{DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern.}}}, volume = {{155}}, year = {{2007}}, } @article{27710, author = {{Buyken, Anette and Liese, A. D.}}, issn = {{0149-5992}}, journal = {{Diabetes Care}}, pages = {{2986--2986}}, title = {{{Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et al.}}}, doi = {{10.2337/diacare.28.12.2986}}, year = {{2007}}, } @article{27789, author = {{Buyken, Anette and von Eckardstein, Arnold and Schulte, Helmut and Cullen, Paul and Assmann, Gerd}}, issn = {{1741-8267}}, journal = {{European Journal of Cardiovascular Prevention & Rehabilitation}}, pages = {{230--236}}, title = {{{Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study}}}, doi = {{10.1097/hjr.0b013e3280142037}}, year = {{2007}}, } @article{27889, author = {{Schlegel-Matthies, Kirsten}}, journal = {{Haushalt & Bildung}}, number = {{1}}, pages = {{35--46}}, title = {{{Zum Umgang mit Vielfalt im haushaltsbezogenen Unterricht}}}, volume = {{84}}, year = {{2007}}, } @article{27890, author = {{Schlegel-Matthies, Kirsten}}, journal = {{Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen}}, number = {{2}}, pages = {{89--96}}, title = {{{Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns}}}, volume = {{15}}, year = {{2007}}, } @book{27891, author = {{Oepping, A. and Schlegel-Matthies, Kirsten}}, publisher = {{aid}}, title = {{{REVIS - Moderne Ernährungs- und Verbraucherbildung}}}, year = {{2007}}, } @article{54935, abstract = {{Expression of connective tissue growth factor (CTGF) in endothelial cells is modulated by shear stress affecting the organization of the cytoskeleton. The molecular connection between alterations of actin and CTGF expression was investigated in human umbilical vein endothelial cells (HUVEC) and a microvascular endothelial cell line. Overexpression of nonpolymerizable monomeric actin R62D interfered with stress fiber formation in HUVEC and concomitantly reduced immunoreactive CTGF. In microvascular endothelial cells, flow-dependent upregulation of CTGF was prevented by this actin mutant. In contrast, overexpression of actin S14C strengthened filamentous actin and increased CTGF expression. These data indicated an inverse relationship between CTGF expression and monomeric actin. Coexpression of the mutant actins and different CTGF promoter constructs revealed an actin-sensitive site between 3 and 4.5 kb of the CTGF promoter. A CArG-like box at -3791 bp was responsible for actin-dependent CTGF induction as shown by mutagenesis. Overexpression of actin S14C activated the nonmutated promoter significantly more strongly than the mutated promoter. Actin polymerization is regulated by the small GTPase RhoA and activation of serum response factor (SRF). Overexpression of constitutively active RhoA or SRF significantly increased CTGF protein synthesis. The 4.5-kb promoter construct, but not the construct with a mutation in the CArG box, was activated by SRF or RhoA, providing evidence for a functional role of this site in CTGF induction. These findings provide novel evidence that monomeric actin is the connecting link between alterations in the cytoskeleton and CTGF gene expression and demonstrate the importance of SRF in regulating CTGF transcription.}}, author = {{Muehlich, Susanne and Cicha, Iwona and Garlichs, Christoph D. and Krueger, Bettina and Posern, Guido and Goppelt-Struebe, Margarete}}, journal = {{American Journal of Physiology-Cell Physiology}}, number = {{5}}, pages = {{C1732–C1738}}, publisher = {{American Physiological Society}}, title = {{{Actin-dependent regulation of connective tissue growth factor}}}, doi = {{10.1152/ajpcell.00552.2006}}, volume = {{292}}, year = {{2007}}, } @inproceedings{54946, abstract = {{The investigation and the development of self-organizing systems are especially needed for operation and control in massively distributed systems such as Sensor and Actor Networks (SANETs). The main issues addressed by self-organization techniques are scalability, network lifetime, and real-time support. In the literature, biological principles are often cited as inspirations for technical solutions, especially in the domain of self-organization. This concept already resulted in a good number of solutions with significant impact such as ant-based routing and immune system inspired network security solutions. In this paper, another specific biological field is investigated: cellular signaling cascades for event-specific reaction initiated by individual cells in collaboration with their direct neighbors. Information between cells are transmitted via proteins and result in the cascade of protein–protein or protein–DNA interactions to produce a specific cellular answer, e.g. the activation of cells or the transmission of mediators. These processes are programmed in every individual cell and lead to a coordinated reaction on a higher organization platform. We transferred these mechanisms to operation and control in SANETs. In particular, a rule-based processing scheme relying on the main concepts of cellular signaling cascades has been developed. It is relying on simple local rules and providing problem specific reaction such as local actuation control and data manipulation. We describe this Rule-based Sensor Network (RSN) technology and demonstrate comparative simulation results that show the feasibility of our approach.}}, author = {{Dressler, Falko and Dietrich, Isabel and German, Reinhard and Krueger, Bettina}}, booktitle = {{1st ACM/ICST International Conference on Autonomic Computing and Communication Systems (Autonomics 2007)}}, publisher = {{Association for Computing Machinery (ACM)}}, title = {{{Efficient Operation in Sensor and Actor Networks Inspired by Cellular Signaling Cascades}}}, doi = {{10.1145/1365562.1365572}}, year = {{2007}}, } @inproceedings{54947, abstract = {{In Wireless Sensor Networks (WSNs), address-based routing approaches often lead to severe problems due to node mobility, energy-saving sleep-cycles, and often missing or unreliable address information. Data-centric routing schemes such as flooding or gossiping solve these problems but may lead to congestion or starvation. Based on biologically inspired mechanisms known from cellular signaling pathways, we discovered potentials in enhancing the communication required for self-organization in network environments suffering from data paths with low reliability and time variations of the reliability. Using an importance factor for particular transmissions in combination with feedback loops, the overall quality of the global system can be increased. The resulting algorithm, Weighted Probabilistic Data Dissemination (WPDD), includes an inherent adaptation to changing network conditions. Congestion control is supported as well as prioritized data communication. This paper outlines the working behavior of WPDD and demonstrates its applicability based on selected simulation results.}}, author = {{Dressler, Falko and German, Reinhard and Krueger, Bettina}}, booktitle = {{IEEE Frontiers in the Convergence of Bioscience and Information Technologies (FBIT 2007)}}, pages = {{827–832}}, publisher = {{Institute of Electrical and Electronics Engineers (IEEE)}}, title = {{{Adaptive Data Dissemination in Sensor Networks using WPDD}}}, doi = {{10.1109/FBIT.2007.23}}, year = {{2007}}, } @article{25932, author = {{Buyken, Anette and Kellerhoff, Y and Hahn, S and Kroke, A and Remer, T}}, issn = {{0022-3166}}, journal = {{J Nutr}}, number = {{7}}, pages = {{1828--1833}}, title = {{{Urinary C-peptide excretion in free-living healthy children is related to dietary carbohydrate intake but not to the dietary glycemic index.}}}, doi = {{10.1093/jn/136.7.1828}}, volume = {{136}}, year = {{2006}}, }