TY - JOUR AB - Published meta-analyses indicate significant but inconsistent incident type-2 diabetes (T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is now over a decade ago that a published meta-analysis used a predefined standard to identify valid studies. Considering valid studies only, and using random effects dose–response meta-analysis (DRM) while withdrawing spurious results (p < 0.05), we ascertained whether these relations would support nutrition guidance, specifically for an RR > 1.20 with a lower 95% confidence limit >1.10 across typical intakes (approximately 10th to 90th percentiles of population intakes). The combined T2D–GI RR was 1.27 (1.15–1.40) (p < 0.001, n = 10 studies) per 10 units GI, while that for the T2D–GL RR was 1.26 (1.15–1.37) (p < 0.001, n = 15) per 80 g/d GL in a 2000 kcal (8400 kJ) diet. The corresponding global DRM using restricted cubic splines were 1.87 (1.56–2.25) (p < 0.001, n = 10) and 1.89 (1.66–2.16) (p < 0.001, n = 15) from 47.6 to 76.1 units GI and 73 to 257 g/d GL in a 2000 kcal diet, respectively. In conclusion, among adults initially in good health, diets higher in GI or GL were robustly associated with incident T2D. Together with mechanistic and other data, this supports that consideration should be given to these dietary risk factors in nutrition advice. Concerning the public health relevance at the global level, our evidence indicates that GI and GL are substantial food markers predicting the development of T2D worldwide, for persons of European ancestry and of East Asian ancestry. AU - Livesey, Geoffrey AU - Taylor, Richard AU - Livesey, Helen F. AU - Buyken, Anette AU - Jenkins, David J. A. AU - Augustin, Livia S. A. AU - Sievenpiper, John L. AU - Barclay, Alan W. AU - Liu, Simin AU - Wolever, Thomas M. S. AU - Willett, Walter C. AU - Brighenti, Furio AU - Salas-Salvadó, Jordi AU - Björck, Inger AU - Rizkalla, Salwa W. AU - Riccardi, Gabriele AU - Vecchia, Carlo La AU - Ceriello, Antonio AU - Trichopoulou, Antonia AU - Poli, Andrea AU - Astrup, Arne AU - Kendall, Cyril W. C. AU - Ha, Marie-Ann AU - Baer-Sinnott, Sara AU - Brand-Miller, Jennie C. ID - 27758 JF - Nutrients SN - 2072-6643 TI - Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies ER - TY - JOUR AB - While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-analyses indicate significant relations but consideration of causality has been minimal. Here, the results of our recent meta-analyses of prospective cohort studies of 4 to 26-y follow-up are interpreted in the context of the nine Bradford-Hill criteria for causality, that is: (1) Strength of Association, (2) Consistency, (3) Specificity, (4) Temporality, (5) Biological Gradient, (6) Plausibility, (7) Experimental evidence, (8) Analogy, and (9) Coherence. These criteria necessitated referral to a body of literature wider than prospective cohort studies alone, especially in criteria 6 to 9. In this analysis, all nine of the Hill’s criteria were met for GI and GL indicating that we can be confident of a role for GI and GL as causal factors contributing to incident T2D. In addition, neither dietary fiber nor cereal fiber nor wholegrain were found to be reliable or effective surrogate measures of GI or GL. Finally, our cost–benefit analysis suggests food and nutrition advice favors lower GI or GL and would produce significant potential cost savings in national healthcare budgets. The high confidence in causal associations for incident T2D is sufficient to consider inclusion of GI and GL in food and nutrient-based recommendations. AU - Livesey, Geoffrey AU - Taylor, Richard AU - Livesey, Helen F. AU - Buyken, Anette AU - Jenkins, David J. A. AU - Augustin, Livia S. A. AU - Sievenpiper, John L. AU - Barclay, Alan W. AU - Liu, Simin AU - Wolever, Thomas M. S. AU - Willett, Walter C. AU - Brighenti, Furio AU - Salas-Salvadó, Jordi AU - Björck, Inger AU - Rizkalla, Salwa W. AU - Riccardi, Gabriele AU - Vecchia, Carlo La AU - Ceriello, Antonio AU - Trichopoulou, Antonia AU - Poli, Andrea AU - Astrup, Arne AU - Kendall, Cyril W. C. AU - Ha, Marie-Ann AU - Baer-Sinnott, Sara AU - Brand-Miller, Jennie C. ID - 27759 JF - Nutrients SN - 2072-6643 TI - Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: Assessment of Causal Relations ER - TY - JOUR AU - Oluwagbemigun, Kolade AU - Buyken, Anette AU - Alexy, Ute AU - Schmid, Matthias AU - Herder, Christian AU - Nöthlings, Ute ID - 27772 JF - Cardiovascular Diabetology SN - 1475-2840 TI - Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence–young adulthood cardiometabolic risk markers ER - TY - JOUR AB - While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To estimate the role of lowered 25(OH)vitamin D concentrations in the etiology of depressive disorders, we conducted a two-sample Mendelian randomization (MR) study on depression, i.e., “depressive symptoms” (DS, n = 161,460) and “broad depression” (BD, n = 113,769 cases and 208,811 controls). Six single nucleotide polymorphisms (SNPs), which were genome-wide significantly associated with 25(OH)vitamin D concentrations in 79,366 subjects from the SUNLIGHT genome-wide association study (GWAS), were used as an instrumental variable. None of the six SNPs was associated with DS or BD (all p > 0.05). MR analysis revealed no causal effects of 25(OH)vitamin D concentration, either on DS (inverse variance weighted (IVW); b = 0.025, SE = 0.038, p = 0.52) or on BD (IVW; b = 0.020, SE = 0.012, p = 0.10). Sensitivity analyses confirmed that 25(OH)vitamin D concentrations were not significantly associated with DS or BD. The findings from this MR study indicate no causal relationship between vitamin D concentrations and depressive symptoms, or broad depression. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation. AU - Libuda, Lars AU - Laabs, Björn-Hergen AU - Ludwig, Christine AU - Bühlmeier, Judith AU - Antel, Jochen AU - Hinney, Anke AU - Naaresh, Roaa AU - Föcker, Manuel AU - Hebebrand, Johannes AU - König, Inke R. AU - Peters, Triinu ID - 27026 JF - Nutrients SN - 2072-6643 TI - Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study ER - TY - JOUR AU - Knoll-Pientka, Nadja AU - Bühlmeier, Judith AU - Peters, Triinu AU - Albrecht, Muriel AU - Adams, Frederike AU - Wustrau, Katharina AU - Teufel, Martin AU - Hebebrand, Johannes AU - Föcker, Manuel AU - Libuda, Lars ID - 27025 JF - Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity SN - 1590-1262 TI - Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study ER - TY - JOUR AU - Hebebrand, Johannes AU - Milos, Gabriella AU - Wabitsch, Martin AU - Teufel, Martin AU - Führer, Dagmar AU - Bühlmeier, Judith AU - Libuda, Lars AU - Ludwig, Christine AU - Antel, Jochen ID - 27521 JF - Frontiers in Psychology SN - 1664-1078 TI - Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin ER - TY - JOUR AU - Weber, KS AU - Simon, MC AU - Strassburger, K AU - Markgraf, DF AU - Buyken, Anette AU - Szendroedi, J AU - Müssig, K AU - Roden, M AU - Group, GDS ID - 27981 IS - 6 JF - Nutrients SN - 2072-6643 TI - Habitual Fructose Intake Relates to Insulin Sensitivity and Fatty Liver Index in Recent-Onset Type 2 Diabetes Patients and Individuals without Diabetes. VL - 10 ER - TY - JOUR AU - Buyken, Anette AU - Mela, DJ AU - Dussort, P AU - Johnson, IT AU - Macdonald, IA AU - Stowell, JD AU - FJPH, Brouns ID - 25929 IS - 12 JF - Eur J Clin Nutr SN - 0954-3007 TI - Dietary carbohydrates: a review of international recommendations and the methods used to derive them. VL - 72 ER - TY - JOUR AB - As a result of the increasing labor force participation of mothers, this article questions how twoparent households divide the housework activities of caring, cooking and cleaning. Therefore three types of couples with different labor force participations were formed: Dual-earner couples, couples with additional female income and malebreadwinner couples. The time use for the mentioned activities was examined with a secondary analysis based on the German representative time use surveys of 2012/2013 and 2001/2002. The analysis showed that fulltime mothers spent the lowest amount of time for caring, cooking and cleaning. However, unemployed mothers spent the most time for these activities. Within a decade – from 2001/2002 to 2012/2013 – all mothers have reduced their time spent on household activities. Meanwhile, all parents in 2012/2013 take noticeably more time for child care. Regardless of the mother’s labor force participation, mothers still spent more time for caring, cooking and cleaning, especially on weekdays. Additionally, the everyday housework is divided by gender. Only on weekends, couples with employed mothers shared the care-work almost egalitarian. Zusammenfassung Vor dem Hintergrund der steigenden Erwerbstätigkeit von Müttern geht dieser Beitrag der Frage nach, wie Eltern in Paarbeziehungen die Haushaltsbereiche Betreuung, Beköstigung sowie Wohnungs- und Wäschereinigung untereinander aufteilen. Dazu werden drei Paartypen mit unterschiedlichem Erwerbsumfang gebildet: Zweiverdiener- Paare, Paare mit weiblichem Zuverdienst sowie Paare mit männlichem Familienernährer. Deren Zeitverwendung für die genannten Tätigkeiten wird mithilfe der repräsentativen Zeitverwendungserhebung 2012/2013 und 2001/2002 sekundäranalytisch untersucht. Die Analyse zeigt, dass vollzeiterwerbstätige Mütter täglich am wenigsten Zeit für die drei genannten Arbeitsbereiche im Haushalt aufwenden, nicht erwerbstätige Mütter hingegen am meisten. Innerhalb einer Dekade – von 2001/2002 bis 2012/2013 – haben alle untersuchten Mütter ihre Zeitverwendung für hauswirtschaftliche Tätigkeitsfelder reduziert, zeitgleich nehmen sich Eltern 2012/2013 deutlich mehr Zeit für Betreuungsaufgaben. Unabhängig des Erwerbsumfangs der Mutter ist die Arbeit des Alltags nach wie vor, besonders werktags, weiblich konnotiert und somit geschlechtsdifferenzierend aufgeteilt. Nur am Wochenende zeigt sich in Paaren mit erwerbstätiger Mutter bei der Betreuung eine annährend egalitäre Arbeitsteilung. AU - Klünder, Nina AU - Meier-Gräwe, Uta ID - 26869 JF - Journal of Family Research SN - 2699-2337 TI - Caring, Cooking, Cleaning – repräsentative Zeitverwendungsmuster von Eltern in Paarbeziehungen ER - TY - JOUR AU - Klünder, Nina ID - 26871 JF - Hauswirtschaft und Wissenschaft TI - Zwischen selbst Gekochtem, Thermomix und Schulverpflegung – Innenansichten der Ernährungsversorgung von Familien mit erwerbstätigen Eltern VL - 66 ER - TY - JOUR AU - Buyken, Anette AU - Cheng, Guo AU - Günther, Anke LB AU - Liese, Angela D AU - Remer, Thomas AU - Karaolis-Danckert, Nadina ID - 26890 JF - The American Journal of Clinical Nutrition SN - 0002-9165 TI - Relation of dietary glycemic index, glycemic load, added sugar intake, or fiber intake to the development of body composition between ages 2 and 7 y ER - TY - JOUR AU - Penczynski, Katharina J. AU - Herder, Christian AU - Krupp, Danika AU - Rienks, Johanna AU - Egert, Sarah AU - Wudy, Stefan A. AU - Roden, Michael AU - Remer, Thomas AU - Buyken, Anette ID - 26928 JF - European Journal of Nutrition SN - 1436-6207 TI - Flavonoid intake from fruit and vegetables during adolescence is prospectively associated with a favourable risk factor profile for type 2 diabetes in early adulthood ER - TY - JOUR AU - Della Corte, Karen AU - Perrar, Ines AU - Penczynski, Katharina AU - Schwingshackl, Lukas AU - Herder, Christian AU - Buyken, Anette ID - 26999 JF - Nutrients SN - 2072-6643 TI - Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies ER - TY - JOUR AU - Koch, Stefanie A. J. AU - Alexy, Ute AU - Diederichs, Tanja AU - Buyken, Anette AU - Roßbach, Sarah ID - 27000 JF - PLOS ONE SN - 1932-6203 TI - The relevance of restrained eating behavior for circadian eating patterns in adolescents ER - TY - JOUR AB - This study performed comparative analyses in two pediatric cohorts to identify dietary patterns during primary school years and examined their relevance to body composition development. Nutritional and anthropometric data at the beginning of primary school and two or four years later were available from 298 and 372 participants of IDEFICS-Germany (Identification and prevention of Dietary-induced and lifestyle-induced health Effects In Children and infants Study) and the KOPS (Kiel Obesity Prevention Study) cohort, respectively. Principal component analyses (PCA) and reduced rank regression (RRR) were used to identify dietary patterns at baseline and patterns of change in food group intake during primary school years. RRR extracted patterns explaining variations in changes in body mass index (BMI), fat mass index (FMI), and waist-to-height-ratio (WtHR). Associations between pattern adherence and excess gain in BMI, FMI, or WtHR (>75th percentile) during primary school years were examined using logistic regression. Among PCA patterns, only a change towards a more Mediterranean food choice during primary school years were associated with a favorable body composition development in IDEFICS-Germany (p < 0.05). In KOPS, RRR patterns characterized by a frequent consumption of fast foods or starchy carbohydrate foods were consistently associated with an excess gain in BMI and WtHR (all p < 0.005). In IDEFICS-Germany, excess gain in BMI, FMI, and WtHR were predicted by a frequent consumption of nuts, meat, and pizza at baseline and a decrease in the consumption frequency of protein sources and snack carbohydrates during primary school years (all p < 0.01). The study confirms an adverse impact of fast food consumption on body composition during primary school years. Combinations of protein and carbohydrate sources deserve further investigation. AU - Wolters, Maike AU - Joslowski, Gesa AU - Plachta-Danielzik, Sandra AU - Standl, Marie AU - Müller, Manfred AU - Ahrens, Wolfgang AU - Buyken, Anette ID - 27001 JF - Nutrients SN - 2072-6643 TI - Dietary Patterns in Primary School are of Prospective Relevance for the Development of Body Composition in Two German Pediatric Populations ER - TY - JOUR AU - Schwingshackl, Lukas AU - Buyken, Anette AU - Chaimani, Anna ID - 27002 JF - European Journal of Nutrition SN - 1436-6207 TI - Network meta-analysis reaches nutrition research ER - TY - JOUR AU - Libuda, Lars AU - Hilbig, Annett AU - Berber-Al-Tawil, Seda AU - Kalhoff, Hermann AU - Kersting, Mathilde ID - 27028 JF - European Journal of Nutrition SN - 1436-6207 TI - Association between full breastfeeding, timing of complementary food introduction, and iron status in infancy in Germany: results of a secondary analysis of a randomized trial ER - TY - JOUR AU - Hebebrand, Johannes AU - Peters, Triinu AU - Schijven, Dick AU - Hebebrand, Moritz AU - Grasemann, Corinna AU - Winkler, Thomas W. AU - Heid, Iris M. AU - Antel, Jochen AU - Föcker, Manuel AU - Tegeler, Lisa AU - Brauner, Lena AU - Adan, Roger A.H. AU - Luykx, Jurjen J. AU - Correll, Christoph U. AU - König, Inke R. AU - Hinney, Anke AU - Libuda, Lars ID - 27029 JF - Molecular Metabolism SN - 2212-8778 TI - The role of genetic variation of human metabolism for BMI, mental traits and mental disorders ER - TY - JOUR AU - Föcker, Manuel AU - Antel, Jochen AU - Grasemann, Corinna AU - Führer, Dagmar AU - Timmesfeld, Nina AU - Öztürk, Dana AU - Peters, Triinu AU - Hinney, Anke AU - Hebebrand, Johannes AU - Libuda, Lars ID - 27030 JF - BMC Psychiatry SN - 1471-244X TI - Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients – a randomized controlled trial: study protocol ER - TY - CHAP AU - Hellweg, Joanna ED - Stroot, T. ED - Westphal, P. ID - 27383 T2 - Peer Learning an Hochschulen. Element einer diversitysensiblen, inklusiven Bildung TI - Peer Learning im Lehramtsstudium – Praxisbeispiel einer diversitysensiblen Lernbegleitung im Fach Hauswirtschaft ER -