TY - JOUR
AB - Published meta-analyses indicate significant but inconsistent incident type-2 diabetes (T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is now over a decade ago that a published meta-analysis used a predefined standard to identify valid studies. Considering valid studies only, and using random effects dose–response meta-analysis (DRM) while withdrawing spurious results (p < 0.05), we ascertained whether these relations would support nutrition guidance, specifically for an RR > 1.20 with a lower 95% confidence limit >1.10 across typical intakes (approximately 10th to 90th percentiles of population intakes). The combined T2D–GI RR was 1.27 (1.15–1.40) (p < 0.001, n = 10 studies) per 10 units GI, while that for the T2D–GL RR was 1.26 (1.15–1.37) (p < 0.001, n = 15) per 80 g/d GL in a 2000 kcal (8400 kJ) diet. The corresponding global DRM using restricted cubic splines were 1.87 (1.56–2.25) (p < 0.001, n = 10) and 1.89 (1.66–2.16) (p < 0.001, n = 15) from 47.6 to 76.1 units GI and 73 to 257 g/d GL in a 2000 kcal diet, respectively. In conclusion, among adults initially in good health, diets higher in GI or GL were robustly associated with incident T2D. Together with mechanistic and other data, this supports that consideration should be given to these dietary risk factors in nutrition advice. Concerning the public health relevance at the global level, our evidence indicates that GI and GL are substantial food markers predicting the development of T2D worldwide, for persons of European ancestry and of East Asian ancestry.
AU - Livesey, Geoffrey
AU - Taylor, Richard
AU - Livesey, Helen F.
AU - Buyken, Anette
AU - Jenkins, David J. A.
AU - Augustin, Livia S. A.
AU - Sievenpiper, John L.
AU - Barclay, Alan W.
AU - Liu, Simin
AU - Wolever, Thomas M. S.
AU - Willett, Walter C.
AU - Brighenti, Furio
AU - Salas-Salvadó, Jordi
AU - Björck, Inger
AU - Rizkalla, Salwa W.
AU - Riccardi, Gabriele
AU - Vecchia, Carlo La
AU - Ceriello, Antonio
AU - Trichopoulou, Antonia
AU - Poli, Andrea
AU - Astrup, Arne
AU - Kendall, Cyril W. C.
AU - Ha, Marie-Ann
AU - Baer-Sinnott, Sara
AU - Brand-Miller, Jennie C.
ID - 27758
JF - Nutrients
SN - 2072-6643
TI - Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies
ER -
TY - JOUR
AB - While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-analyses indicate significant relations but consideration of causality has been minimal. Here, the results of our recent meta-analyses of prospective cohort studies of 4 to 26-y follow-up are interpreted in the context of the nine Bradford-Hill criteria for causality, that is: (1) Strength of Association, (2) Consistency, (3) Specificity, (4) Temporality, (5) Biological Gradient, (6) Plausibility, (7) Experimental evidence, (8) Analogy, and (9) Coherence. These criteria necessitated referral to a body of literature wider than prospective cohort studies alone, especially in criteria 6 to 9. In this analysis, all nine of the Hill’s criteria were met for GI and GL indicating that we can be confident of a role for GI and GL as causal factors contributing to incident T2D. In addition, neither dietary fiber nor cereal fiber nor wholegrain were found to be reliable or effective surrogate measures of GI or GL. Finally, our cost–benefit analysis suggests food and nutrition advice favors lower GI or GL and would produce significant potential cost savings in national healthcare budgets. The high confidence in causal associations for incident T2D is sufficient to consider inclusion of GI and GL in food and nutrient-based recommendations.
AU - Livesey, Geoffrey
AU - Taylor, Richard
AU - Livesey, Helen F.
AU - Buyken, Anette
AU - Jenkins, David J. A.
AU - Augustin, Livia S. A.
AU - Sievenpiper, John L.
AU - Barclay, Alan W.
AU - Liu, Simin
AU - Wolever, Thomas M. S.
AU - Willett, Walter C.
AU - Brighenti, Furio
AU - Salas-Salvadó, Jordi
AU - Björck, Inger
AU - Rizkalla, Salwa W.
AU - Riccardi, Gabriele
AU - Vecchia, Carlo La
AU - Ceriello, Antonio
AU - Trichopoulou, Antonia
AU - Poli, Andrea
AU - Astrup, Arne
AU - Kendall, Cyril W. C.
AU - Ha, Marie-Ann
AU - Baer-Sinnott, Sara
AU - Brand-Miller, Jennie C.
ID - 27759
JF - Nutrients
SN - 2072-6643
TI - Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: Assessment of Causal Relations
ER -
TY - JOUR
AU - Oluwagbemigun, Kolade
AU - Buyken, Anette
AU - Alexy, Ute
AU - Schmid, Matthias
AU - Herder, Christian
AU - Nöthlings, Ute
ID - 27772
JF - Cardiovascular Diabetology
SN - 1475-2840
TI - Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence–young adulthood cardiometabolic risk markers
ER -
TY - JOUR
AB - While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To estimate the role of lowered 25(OH)vitamin D concentrations in the etiology of depressive disorders, we conducted a two-sample Mendelian randomization (MR) study on depression, i.e., “depressive symptoms” (DS, n = 161,460) and “broad depression” (BD, n = 113,769 cases and 208,811 controls). Six single nucleotide polymorphisms (SNPs), which were genome-wide significantly associated with 25(OH)vitamin D concentrations in 79,366 subjects from the SUNLIGHT genome-wide association study (GWAS), were used as an instrumental variable. None of the six SNPs was associated with DS or BD (all p > 0.05). MR analysis revealed no causal effects of 25(OH)vitamin D concentration, either on DS (inverse variance weighted (IVW); b = 0.025, SE = 0.038, p = 0.52) or on BD (IVW; b = 0.020, SE = 0.012, p = 0.10). Sensitivity analyses confirmed that 25(OH)vitamin D concentrations were not significantly associated with DS or BD. The findings from this MR study indicate no causal relationship between vitamin D concentrations and depressive symptoms, or broad depression. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation.
AU - Libuda, Lars
AU - Laabs, Björn-Hergen
AU - Ludwig, Christine
AU - Bühlmeier, Judith
AU - Antel, Jochen
AU - Hinney, Anke
AU - Naaresh, Roaa
AU - Föcker, Manuel
AU - Hebebrand, Johannes
AU - König, Inke R.
AU - Peters, Triinu
ID - 27026
JF - Nutrients
SN - 2072-6643
TI - Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study
ER -
TY - JOUR
AU - Knoll-Pientka, Nadja
AU - Bühlmeier, Judith
AU - Peters, Triinu
AU - Albrecht, Muriel
AU - Adams, Frederike
AU - Wustrau, Katharina
AU - Teufel, Martin
AU - Hebebrand, Johannes
AU - Föcker, Manuel
AU - Libuda, Lars
ID - 27025
JF - Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity
SN - 1590-1262
TI - Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study
ER -
TY - JOUR
AU - Hebebrand, Johannes
AU - Milos, Gabriella
AU - Wabitsch, Martin
AU - Teufel, Martin
AU - Führer, Dagmar
AU - Bühlmeier, Judith
AU - Libuda, Lars
AU - Ludwig, Christine
AU - Antel, Jochen
ID - 27521
JF - Frontiers in Psychology
SN - 1664-1078
TI - Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin
ER -
TY - JOUR
AU - Weber, KS
AU - Simon, MC
AU - Strassburger, K
AU - Markgraf, DF
AU - Buyken, Anette
AU - Szendroedi, J
AU - Müssig, K
AU - Roden, M
AU - Group, GDS
ID - 27981
IS - 6
JF - Nutrients
SN - 2072-6643
TI - Habitual Fructose Intake Relates to Insulin Sensitivity and Fatty Liver Index in Recent-Onset Type 2 Diabetes Patients and Individuals without Diabetes.
VL - 10
ER -
TY - JOUR
AU - Buyken, Anette
AU - Mela, DJ
AU - Dussort, P
AU - Johnson, IT
AU - Macdonald, IA
AU - Stowell, JD
AU - FJPH, Brouns
ID - 25929
IS - 12
JF - Eur J Clin Nutr
SN - 0954-3007
TI - Dietary carbohydrates: a review of international recommendations and the methods used to derive them.
VL - 72
ER -
TY - JOUR
AB - As a result of the increasing labor force participation of mothers, this article questions how twoparent households divide the housework activities of caring, cooking and cleaning. Therefore three types of couples with different labor force participations were formed: Dual-earner couples, couples with additional female income and malebreadwinner couples. The time use for the mentioned activities was examined with a secondary analysis based on the German representative time use surveys of 2012/2013 and 2001/2002. The analysis showed that fulltime mothers spent the lowest amount of time for caring, cooking and cleaning. However, unemployed mothers spent the most time for these activities. Within a decade – from 2001/2002 to 2012/2013 – all mothers have reduced their time spent on household activities. Meanwhile, all parents in 2012/2013 take noticeably more time for child care. Regardless of the mother’s labor force participation, mothers still spent more time for caring, cooking and cleaning, especially on weekdays. Additionally, the everyday housework is divided by gender. Only on weekends, couples with employed mothers shared the care-work almost egalitarian.
Zusammenfassung
Vor dem Hintergrund der steigenden Erwerbstätigkeit von Müttern geht dieser Beitrag der Frage nach, wie Eltern in Paarbeziehungen die Haushaltsbereiche Betreuung, Beköstigung sowie Wohnungs- und Wäschereinigung untereinander aufteilen. Dazu werden drei Paartypen mit unterschiedlichem Erwerbsumfang gebildet: Zweiverdiener- Paare, Paare mit weiblichem Zuverdienst sowie Paare mit männlichem Familienernährer. Deren Zeitverwendung für die genannten Tätigkeiten wird mithilfe der repräsentativen Zeitverwendungserhebung 2012/2013 und 2001/2002 sekundäranalytisch untersucht. Die Analyse zeigt, dass vollzeiterwerbstätige Mütter täglich am wenigsten Zeit für die drei genannten Arbeitsbereiche im Haushalt aufwenden, nicht erwerbstätige Mütter hingegen am meisten. Innerhalb einer Dekade – von 2001/2002 bis 2012/2013 – haben alle untersuchten Mütter ihre Zeitverwendung für hauswirtschaftliche Tätigkeitsfelder reduziert, zeitgleich nehmen sich Eltern 2012/2013 deutlich mehr Zeit für Betreuungsaufgaben. Unabhängig des Erwerbsumfangs der Mutter ist die Arbeit des Alltags nach wie vor, besonders werktags, weiblich konnotiert und somit geschlechtsdifferenzierend aufgeteilt. Nur am Wochenende zeigt sich in Paaren mit erwerbstätiger Mutter bei der Betreuung eine annährend egalitäre Arbeitsteilung.
AU - Klünder, Nina
AU - Meier-Gräwe, Uta
ID - 26869
JF - Journal of Family Research
SN - 2699-2337
TI - Caring, Cooking, Cleaning – repräsentative Zeitverwendungsmuster von Eltern in Paarbeziehungen
ER -
TY - JOUR
AU - Klünder, Nina
ID - 26871
JF - Hauswirtschaft und Wissenschaft
TI - Zwischen selbst Gekochtem, Thermomix und Schulverpflegung – Innenansichten der Ernährungsversorgung von Familien mit erwerbstätigen Eltern
VL - 66
ER -
TY - JOUR
AU - Buyken, Anette
AU - Cheng, Guo
AU - Günther, Anke LB
AU - Liese, Angela D
AU - Remer, Thomas
AU - Karaolis-Danckert, Nadina
ID - 26890
JF - The American Journal of Clinical Nutrition
SN - 0002-9165
TI - Relation of dietary glycemic index, glycemic load, added sugar intake, or fiber intake to the development of body composition between ages 2 and 7 y
ER -
TY - JOUR
AU - Penczynski, Katharina J.
AU - Herder, Christian
AU - Krupp, Danika
AU - Rienks, Johanna
AU - Egert, Sarah
AU - Wudy, Stefan A.
AU - Roden, Michael
AU - Remer, Thomas
AU - Buyken, Anette
ID - 26928
JF - European Journal of Nutrition
SN - 1436-6207
TI - Flavonoid intake from fruit and vegetables during adolescence is prospectively associated with a favourable risk factor profile for type 2 diabetes in early adulthood
ER -
TY - JOUR
AU - Della Corte, Karen
AU - Perrar, Ines
AU - Penczynski, Katharina
AU - Schwingshackl, Lukas
AU - Herder, Christian
AU - Buyken, Anette
ID - 26999
JF - Nutrients
SN - 2072-6643
TI - Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies
ER -
TY - JOUR
AU - Koch, Stefanie A. J.
AU - Alexy, Ute
AU - Diederichs, Tanja
AU - Buyken, Anette
AU - Roßbach, Sarah
ID - 27000
JF - PLOS ONE
SN - 1932-6203
TI - The relevance of restrained eating behavior for circadian eating patterns in adolescents
ER -
TY - JOUR
AB - This study performed comparative analyses in two pediatric cohorts to identify dietary patterns during primary school years and examined their relevance to body composition development. Nutritional and anthropometric data at the beginning of primary school and two or four years later were available from 298 and 372 participants of IDEFICS-Germany (Identification and prevention of Dietary-induced and lifestyle-induced health Effects In Children and infants Study) and the KOPS (Kiel Obesity Prevention Study) cohort, respectively. Principal component analyses (PCA) and reduced rank regression (RRR) were used to identify dietary patterns at baseline and patterns of change in food group intake during primary school years. RRR extracted patterns explaining variations in changes in body mass index (BMI), fat mass index (FMI), and waist-to-height-ratio (WtHR). Associations between pattern adherence and excess gain in BMI, FMI, or WtHR (>75th percentile) during primary school years were examined using logistic regression. Among PCA patterns, only a change towards a more Mediterranean food choice during primary school years were associated with a favorable body composition development in IDEFICS-Germany (p < 0.05). In KOPS, RRR patterns characterized by a frequent consumption of fast foods or starchy carbohydrate foods were consistently associated with an excess gain in BMI and WtHR (all p < 0.005). In IDEFICS-Germany, excess gain in BMI, FMI, and WtHR were predicted by a frequent consumption of nuts, meat, and pizza at baseline and a decrease in the consumption frequency of protein sources and snack carbohydrates during primary school years (all p < 0.01). The study confirms an adverse impact of fast food consumption on body composition during primary school years. Combinations of protein and carbohydrate sources deserve further investigation.
AU - Wolters, Maike
AU - Joslowski, Gesa
AU - Plachta-Danielzik, Sandra
AU - Standl, Marie
AU - Müller, Manfred
AU - Ahrens, Wolfgang
AU - Buyken, Anette
ID - 27001
JF - Nutrients
SN - 2072-6643
TI - Dietary Patterns in Primary School are of Prospective Relevance for the Development of Body Composition in Two German Pediatric Populations
ER -
TY - JOUR
AU - Schwingshackl, Lukas
AU - Buyken, Anette
AU - Chaimani, Anna
ID - 27002
JF - European Journal of Nutrition
SN - 1436-6207
TI - Network meta-analysis reaches nutrition research
ER -
TY - JOUR
AU - Libuda, Lars
AU - Hilbig, Annett
AU - Berber-Al-Tawil, Seda
AU - Kalhoff, Hermann
AU - Kersting, Mathilde
ID - 27028
JF - European Journal of Nutrition
SN - 1436-6207
TI - Association between full breastfeeding, timing of complementary food introduction, and iron status in infancy in Germany: results of a secondary analysis of a randomized trial
ER -
TY - JOUR
AU - Hebebrand, Johannes
AU - Peters, Triinu
AU - Schijven, Dick
AU - Hebebrand, Moritz
AU - Grasemann, Corinna
AU - Winkler, Thomas W.
AU - Heid, Iris M.
AU - Antel, Jochen
AU - Föcker, Manuel
AU - Tegeler, Lisa
AU - Brauner, Lena
AU - Adan, Roger A.H.
AU - Luykx, Jurjen J.
AU - Correll, Christoph U.
AU - König, Inke R.
AU - Hinney, Anke
AU - Libuda, Lars
ID - 27029
JF - Molecular Metabolism
SN - 2212-8778
TI - The role of genetic variation of human metabolism for BMI, mental traits and mental disorders
ER -
TY - JOUR
AU - Föcker, Manuel
AU - Antel, Jochen
AU - Grasemann, Corinna
AU - Führer, Dagmar
AU - Timmesfeld, Nina
AU - Öztürk, Dana
AU - Peters, Triinu
AU - Hinney, Anke
AU - Hebebrand, Johannes
AU - Libuda, Lars
ID - 27030
JF - BMC Psychiatry
SN - 1471-244X
TI - Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients – a randomized controlled trial: study protocol
ER -
TY - CHAP
AU - Hellweg, Joanna
ED - Stroot, T.
ED - Westphal, P.
ID - 27383
T2 - Peer Learning an Hochschulen. Element einer diversitysensiblen, inklusiven Bildung
TI - Peer Learning im Lehramtsstudium – Praxisbeispiel einer diversitysensiblen Lernbegleitung im Fach Hauswirtschaft
ER -