TY - JOUR AU - Stutz, Bianca AU - Buyken, Anette AU - Schadow, A.M. AU - Jankovic, N. AU - Alexy, U. AU - Krueger, B. ID - 35754 JF - Appetite KW - Nutrition and Dietetics KW - General Psychology SN - 0195-6663 TI - Associations of chronotype and social jetlag with eating jetlag and their changes among German students during the first COVID-19 lockdown. The Chronotype and Nutrition study VL - 180 ER - TY - JOUR AU - Goletzke, J AU - Weber, KS AU - Kössler, T AU - Zaharia, OP AU - Bódis, K AU - Müssig, K AU - Szendroedi, J AU - Burkart, V AU - Stutz, Bianca AU - Nöthlings, U AU - Buyken, Anette AU - Roden, M AU - Group, GDS ID - 35310 IS - 10 JF - Nutr Metab Cardiovasc Dis SN - 0939-4753 TI - Relative validity of a glycemic index extended food-frequency questionnaire. VL - 32 ER - TY - CHAP AU - Freymuth, Nina ED - Benz, Benjamin ED - Schönig, Werner ED - Arp, Anna Liza ED - Lutz, Katharina ED - Offergeld, Jana ID - 45605 T2 - Wissenschaftsläden in der Sozialen Arbeit. Partizipative Forschung und soziale Innovationen TI - Zum Einstieg: Master-Arbeit zu ökologischer und sozial gerechter Stadtplanung. Ein fiktives Beispiel ER - TY - JOUR AB - AbstractTo summarize current knowledge and gaps regarding the role of postprandial glycaemic response in the paediatric population, a workshop was organized in June 2021 by the European branch of the International Life Science Institute (ILSI). This virtual event comprised of talks given by experts followed by in-depth discussions in breakout sessions with workshop participants. The main pre-specified topics addressed by the workshop organizing committee to the invited speakers and the workshop participants were: (1) the role of glycaemic responses for paediatric health, based on mechanistic insights from animal and human data, and long-term evidence from observational and intervention studies in paediatric populations, and (2) changes in metabolism and changes in dietary needs from infancy to adolescence. Each talk as well as the discussions were summarised, including the main identified research gaps. The workshop led to the consensus on the crucial role on health of postprandial glycaemic response in paediatric population. However, a lack of scientific data has been identified regarding detailed glucose and insulin profiles in response to foods commonly consumed by paediatric populations, as well as a lack of long-term evidence including the need for suitable predictors during childhood and adolescence to anticipate health effects during adulthood. AU - Vinoy, Sophie AU - Goletzke, Janina AU - Rakhshandehroo, Maryam AU - Schweitzer, Lisa AU - Flourakis, Matthieu AU - Körner, Antje AU - Alexy, Ute AU - van Schothorst, Evert M. AU - Ceriello, Antonio AU - Zakrzewski-Fruer, Julia K. AU - Buyken, Anette ID - 45809 IS - 3 JF - European Journal of Nutrition KW - Nutrition and Dietetics KW - Medicine (miscellaneous) SN - 1436-6207 TI - Health relevance of lowering postprandial glycaemia in the paediatric population through diet’: results from a multistakeholder workshop VL - 62 ER - TY - JOUR AU - Schadow, Alena M. AU - Revheim, Ingrid AU - Spielau, Ulrike AU - Dierkes, Jutta AU - Schwingshackl, Lukas AU - Frank, Jan AU - Hodgson, Jonathan M. AU - Moreira-Rosário, André AU - Seal, Chris J. AU - Buyken, Anette AU - Rosendahl-Riise, Hanne ID - 45808 IS - 1 JF - Advances in Nutrition KW - Nutrition and Dietetics KW - Medicine (miscellaneous) KW - Food Science SN - 2161-8313 TI - The Effect of Regular Consumption of Reformulated Breads on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Clinical Trials VL - 14 ER - TY - JOUR AB - Aufgrund der heterogenen Schülerschaft im Berufsfeld Ernährung und Hauswirtschaft müssen Studierende für sprachbildenden Fachunterricht professionalisiert werden. Aufbauend auf einer theoretischen Fundierung werden konkrete Umsetzungsbeispiele anhand von drei exemplarischen Online-Modulen für den Ausbildungsberuf Hotelfachfrau/-mann vorgestellt. AU - Dehn, Freya AU - Meyer, Anja AU - Niederhaus, Constanze AU - Schlegel-Matthies, Kirsten ID - 33952 IS - 3 JF - HiBiFo – Haushalt in Bildung & Forschung SN - 2193-8806 TI - Professionalisierung von Lehramtsstudierenden für sprachbildenden Fachunterricht im Berufsfeld Ernährung und Hauswirtschaft VL - 11 ER - TY - JOUR AU - Barclay, AW AU - LSA, Augustin AU - Brighenti, F AU - Delport, E AU - Henry, CJ AU - Sievenpiper, JL AU - Usic, K AU - Yuexin, Y AU - Zurbau, A AU - TMS, Wolever AU - Astrup, A AU - Bulló, M AU - Buyken, Anette AU - Ceriello, A AU - Ellis, PR AU - Vanginkel, MA AU - CWC, Kendall AU - La Vecchia, C AU - Livesey, G AU - Poli, A AU - Riccardi, G AU - Salas-Salvadó, J AU - Trichopoulou, A AU - Bhaskaran, K AU - DJA, Jenkins AU - Willett, WC AU - Brand-Miller, JC ID - 27970 IS - 9 JF - Nutrients SN - 2072-6643 TI - Dietary Glycaemic Index Labelling: A Global Perspective. VL - 13 ER - TY - JOUR AU - Hirtz, Raphael AU - Focker, Manuel AU - Libuda, Lars AU - Antel, Jochen AU - Ozturk, Dana AU - Kiewert, Cordula AU - Munteanu, Martin AU - Peters, Triinu AU - Fuhrer, Dagmar AU - Zwanziger, Denise AU - Thamm, Michael AU - Hebebrand, Johannes AU - Grasemann, Corinna ID - 26420 JF - The Journal of Clinical Psychiatry SN - 1555-2101 TI - Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents ER - TY - JOUR AB - AbstractWith this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN. AU - Antel, Jochen AU - Tan, Susanne AU - Grabler, Marvin AU - Ludwig, Christine AU - Lohkemper, Dominik AU - Brandenburg, Tim AU - Barth, Nikolaus AU - Hinney, Anke AU - Libuda, Lars AU - Remy, Miriam AU - Milos, Gabriella AU - Hebebrand, Johannes ID - 26523 JF - European Child & Adolescent Psychiatry SN - 1018-8827 TI - Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism ER - TY - CHAP AU - Schlegel-Matthies, Kirsten AU - Wespi, Claudia ED - Reinhardt, V. ED - Rehm , M. ED - Wilhem , M. ID - 26633 T2 - Wirksamer Fachunterricht. Eine metaanalytische Betrachtung von Expertisen aus 17 Schulfächern TI - Befähigung zur Reflexion und zum Umgang mit Ambiguitäten. Zur Wirksamkeit von Unterricht für "Lebensführung" ER - TY - BOOK AU - Schlegel-Matthies, Kirsten AU - Wespi, Claudia ID - 26635 SN - ISBN-13: 9783834020314 TI - Wirksamer Unterricht für Lebensführung. (Unterrichtsqualität: Perspektiven von Expertinnen und Experten 12) VL - 12 ER - TY - CHAP AU - Klünder, Nina ED - Amthor, Ralph-Christian ED - Goldberg, Brigitta ED - Hansbauer, Peter ED - Landes, Benjamin ED - Wintergerst, Theresia ID - 26874 SN - 978-3-7799-3869-9 T2 - Wörterbuch. Soziale Arbeit TI - Wörterbuch. Soziale Arbeit ER - TY - JOUR AB - Abstract Purpose To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood. Methods Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses. Results On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (Ptrend = 0.02) and FLI (Ptrend = 0.03). On the urinary excretion level, however, a higher FE (Ptrend = 0.03) and FE + SE (Ptrend = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI. Conclusion The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted. AU - Perrar, Ines AU - Buyken, Anette AU - Penczynski, Katharina J. AU - Remer, Thomas AU - Kuhnle, Gunter G. AU - Herder, Christian AU - Roden, Michael AU - Della Corte, Karen AU - Nöthlings, Ute AU - Alexy, Ute ID - 27007 JF - European Journal of Nutrition SN - 1436-6207 TI - Relevance of fructose intake in adolescence for fatty liver indices in young adulthood ER - TY - JOUR AB - Purpose: To examine the prospective relevance of dietary sugar intake (based on dietary data as well as urinary excretion data) in adolescent years for insulin sensitivity and biomarkers of inflammation in young adulthood.Methods: Overall 254 participants of the DONALD study who had at least two 3-day weighed dietary records for calculating intakes of fructose, glucose, sucrose, total, free, added sugars, total sugars from sugar-sweetened beverages (SSB), juice, and sweets/sugar or at least two complete 24 h urine samples (n = 221) for calculating sugar excretion (urinary fructose and urinary fructose + sucrose) in adolescence (females: 9–15 years, males: 10–16 years) and a fasting blood sample in adulthood (18–36 years), were included in multivariable linear regression analyses assessing their prospective associations with adult homeostasis model assessment insulin sensitivity (HOMA2-%S) and a pro-inflammatory score (based on CRP, IL-6, IL-18, leptin, chemerin, adiponectin).Results: On the dietary intake level, no prospective associations were observed between adolescent fructose, sucrose, glucose, added, free, total sugar, or total sugar from SSB, juice or sweets/sugar intake and adult HOMA2-%S (p &gt; 0.01). On the urinary level, however, higher excreted fructose levels were associated with improved adult HOMA2-%S (p = 0.008) among females only. No associations were observed between dietary or urinary sugars and the adult pro-inflammatory score (p &gt; 0.01).Conclusion: The present study did not provide support that dietary sugar consumed in adolescence is associated with adult insulin sensitivity. The one potential exception was the moderate dietary consumption of fructose, which showed a beneficial association with adult fasting insulin and insulin sensitivity. AU - Della Corte, Karen A. AU - Penczynski, Katharina AU - Kuhnle, Gunter AU - Perrar, Ines AU - Herder, Christian AU - Roden, Michael AU - Wudy, Stefan A. AU - Remer, Thomas AU - Alexy, Ute AU - Buyken, Anette ID - 27014 JF - Frontiers in Nutrition SN - 2296-861X TI - The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood ER - TY - JOUR AB - Abstract Background/objectives Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence. Subjects/methods We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9–17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (N = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m2)]) and Fat Mass Index (FMI) [kg/m2)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at <12 years, ≥12 to ≤15 years and >15 years). Results Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01–0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01–0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003–0.08). Associations were stronger for the age group ≥12 to ≤15 years (p for interaction: <0.001). No relationship was found with FFMI. Conclusions Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness. AU - Jankovic, Nicole AU - Schmitting, Sarah AU - Krüger, Bettina AU - Nöthlings, Ute AU - Buyken, Anette E. AU - Alexy, Ute ID - 27114 JF - European Journal of Clinical Nutrition SN - 0954-3007 TI - Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study ER - TY - JOUR AB - Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. AU - Hirtz, Raphael AU - Zheng, Yiran AU - Rajcsanyi, Luisa S. AU - Libuda, Lars AU - Antel, Jochen AU - Peters, Triinu AU - Hebebrand, Johannes AU - Hinney, Anke ID - 27572 JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie SN - 1422-4917 TI - Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts ER - TY - JOUR AB - Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung. AU - Libuda, Lars AU - Hebebrand, Johannes AU - Föcker, Manuel AU - Peters, Triinu AU - Hinney, Anke ID - 27573 JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie SN - 1422-4917 TI - Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken ER - TY - JOUR AB - In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = &lt;.001, d = 1.35, large effect size, and p = &lt;.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults. AU - Hirtz, Raphael AU - Libuda, Lars AU - Hinney, Anke AU - Föcker, Manuel AU - Bühlmeier, Judith AU - Antel, Jochen AU - Holterhus, Paul-Martin AU - Kulle, Alexandra AU - Kiewert, Cordula AU - Hebebrand, Johannes AU - Grasemann, Corinna ID - 27574 JF - Frontiers in Endocrinology SN - 1664-2392 TI - Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression ER - TY - JOUR AU - Zhang, Xiao AU - Gong, Yunhui AU - Della Corte, Karen AU - Yu, Dianke AU - Xue, Hongmei AU - Shan, Shufang AU - Tian, Guo AU - Liang, Yi AU - Zhang, Jieyi AU - He, Fang AU - Yang, Dagang AU - Zhou, Rong AU - Bao, Wei AU - Buyken, Anette AU - Cheng, Guo ID - 27746 JF - Clinical Nutrition SN - 0261-5614 TI - Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis ER - TY - JOUR AU - Nyasordzi, Juliana AU - Conrad, Johanna AU - Goletzke, Janina AU - Ludwig-Walz, Helena AU - Herder, Christian AU - Roden, Michael AU - Wudy, Stefan A. AU - Hua, Yifan AU - Remer, Thomas AU - Buyken, Anette ID - 27790 JF - Nutrition, Metabolism and Cardiovascular Diseases SN - 0939-4753 TI - Early life factors and their relevance for markers of cardiometabolic risk in early adulthood ER -