TY - JOUR
AU - Stutz, Bianca
AU - Buyken, Anette
AU - Schadow, A.M.
AU - Jankovic, N.
AU - Alexy, U.
AU - Krueger, B.
ID - 35754
JF - Appetite
KW - Nutrition and Dietetics
KW - General Psychology
SN - 0195-6663
TI - Associations of chronotype and social jetlag with eating jetlag and their changes among German students during the first COVID-19 lockdown. The Chronotype and Nutrition study
VL - 180
ER -
TY - JOUR
AU - Goletzke, J
AU - Weber, KS
AU - Kössler, T
AU - Zaharia, OP
AU - Bódis, K
AU - Müssig, K
AU - Szendroedi, J
AU - Burkart, V
AU - Stutz, Bianca
AU - Nöthlings, U
AU - Buyken, Anette
AU - Roden, M
AU - Group, GDS
ID - 35310
IS - 10
JF - Nutr Metab Cardiovasc Dis
SN - 0939-4753
TI - Relative validity of a glycemic index extended food-frequency questionnaire.
VL - 32
ER -
TY - CHAP
AU - Freymuth, Nina
ED - Benz, Benjamin
ED - Schönig, Werner
ED - Arp, Anna Liza
ED - Lutz, Katharina
ED - Offergeld, Jana
ID - 45605
T2 - Wissenschaftsläden in der Sozialen Arbeit. Partizipative Forschung und soziale Innovationen
TI - Zum Einstieg: Master-Arbeit zu ökologischer und sozial gerechter Stadtplanung. Ein fiktives Beispiel
ER -
TY - JOUR
AB - AbstractTo summarize current knowledge and gaps regarding the role of postprandial glycaemic response in the paediatric population, a workshop was organized in June 2021 by the European branch of the International Life Science Institute (ILSI). This virtual event comprised of talks given by experts followed by in-depth discussions in breakout sessions with workshop participants. The main pre-specified topics addressed by the workshop organizing committee to the invited speakers and the workshop participants were: (1) the role of glycaemic responses for paediatric health, based on mechanistic insights from animal and human data, and long-term evidence from observational and intervention studies in paediatric populations, and (2) changes in metabolism and changes in dietary needs from infancy to adolescence. Each talk as well as the discussions were summarised, including the main identified research gaps. The workshop led to the consensus on the crucial role on health of postprandial glycaemic response in paediatric population. However, a lack of scientific data has been identified regarding detailed glucose and insulin profiles in response to foods commonly consumed by paediatric populations, as well as a lack of long-term evidence including the need for suitable predictors during childhood and adolescence to anticipate health effects during adulthood.
AU - Vinoy, Sophie
AU - Goletzke, Janina
AU - Rakhshandehroo, Maryam
AU - Schweitzer, Lisa
AU - Flourakis, Matthieu
AU - Körner, Antje
AU - Alexy, Ute
AU - van Schothorst, Evert M.
AU - Ceriello, Antonio
AU - Zakrzewski-Fruer, Julia K.
AU - Buyken, Anette
ID - 45809
IS - 3
JF - European Journal of Nutrition
KW - Nutrition and Dietetics
KW - Medicine (miscellaneous)
SN - 1436-6207
TI - Health relevance of lowering postprandial glycaemia in the paediatric population through diet’: results from a multistakeholder workshop
VL - 62
ER -
TY - JOUR
AU - Schadow, Alena M.
AU - Revheim, Ingrid
AU - Spielau, Ulrike
AU - Dierkes, Jutta
AU - Schwingshackl, Lukas
AU - Frank, Jan
AU - Hodgson, Jonathan M.
AU - Moreira-Rosário, André
AU - Seal, Chris J.
AU - Buyken, Anette
AU - Rosendahl-Riise, Hanne
ID - 45808
IS - 1
JF - Advances in Nutrition
KW - Nutrition and Dietetics
KW - Medicine (miscellaneous)
KW - Food Science
SN - 2161-8313
TI - The Effect of Regular Consumption of Reformulated Breads on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
VL - 14
ER -
TY - JOUR
AB - Aufgrund der heterogenen Schülerschaft im Berufsfeld Ernährung und Hauswirtschaft müssen Studierende für sprachbildenden Fachunterricht professionalisiert werden. Aufbauend auf einer theoretischen Fundierung werden konkrete Umsetzungsbeispiele anhand von drei exemplarischen Online-Modulen für den Ausbildungsberuf Hotelfachfrau/-mann vorgestellt.
AU - Dehn, Freya
AU - Meyer, Anja
AU - Niederhaus, Constanze
AU - Schlegel-Matthies, Kirsten
ID - 33952
IS - 3
JF - HiBiFo – Haushalt in Bildung & Forschung
SN - 2193-8806
TI - Professionalisierung von Lehramtsstudierenden für sprachbildenden Fachunterricht im Berufsfeld Ernährung und Hauswirtschaft
VL - 11
ER -
TY - JOUR
AU - Barclay, AW
AU - LSA, Augustin
AU - Brighenti, F
AU - Delport, E
AU - Henry, CJ
AU - Sievenpiper, JL
AU - Usic, K
AU - Yuexin, Y
AU - Zurbau, A
AU - TMS, Wolever
AU - Astrup, A
AU - Bulló, M
AU - Buyken, Anette
AU - Ceriello, A
AU - Ellis, PR
AU - Vanginkel, MA
AU - CWC, Kendall
AU - La Vecchia, C
AU - Livesey, G
AU - Poli, A
AU - Riccardi, G
AU - Salas-Salvadó, J
AU - Trichopoulou, A
AU - Bhaskaran, K
AU - DJA, Jenkins
AU - Willett, WC
AU - Brand-Miller, JC
ID - 27970
IS - 9
JF - Nutrients
SN - 2072-6643
TI - Dietary Glycaemic Index Labelling: A Global Perspective.
VL - 13
ER -
TY - JOUR
AU - Hirtz, Raphael
AU - Focker, Manuel
AU - Libuda, Lars
AU - Antel, Jochen
AU - Ozturk, Dana
AU - Kiewert, Cordula
AU - Munteanu, Martin
AU - Peters, Triinu
AU - Fuhrer, Dagmar
AU - Zwanziger, Denise
AU - Thamm, Michael
AU - Hebebrand, Johannes
AU - Grasemann, Corinna
ID - 26420
JF - The Journal of Clinical Psychiatry
SN - 1555-2101
TI - Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents
ER -
TY - JOUR
AB - AbstractWith this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN.
AU - Antel, Jochen
AU - Tan, Susanne
AU - Grabler, Marvin
AU - Ludwig, Christine
AU - Lohkemper, Dominik
AU - Brandenburg, Tim
AU - Barth, Nikolaus
AU - Hinney, Anke
AU - Libuda, Lars
AU - Remy, Miriam
AU - Milos, Gabriella
AU - Hebebrand, Johannes
ID - 26523
JF - European Child & Adolescent Psychiatry
SN - 1018-8827
TI - Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism
ER -
TY - CHAP
AU - Schlegel-Matthies, Kirsten
AU - Wespi, Claudia
ED - Reinhardt, V.
ED - Rehm , M.
ED - Wilhem , M.
ID - 26633
T2 - Wirksamer Fachunterricht. Eine metaanalytische Betrachtung von Expertisen aus 17 Schulfächern
TI - Befähigung zur Reflexion und zum Umgang mit Ambiguitäten. Zur Wirksamkeit von Unterricht für "Lebensführung"
ER -
TY - BOOK
AU - Schlegel-Matthies, Kirsten
AU - Wespi, Claudia
ID - 26635
SN - ISBN-13: 9783834020314
TI - Wirksamer Unterricht für Lebensführung. (Unterrichtsqualität: Perspektiven von Expertinnen und Experten 12)
VL - 12
ER -
TY - CHAP
AU - Klünder, Nina
ED - Amthor, Ralph-Christian
ED - Goldberg, Brigitta
ED - Hansbauer, Peter
ED - Landes, Benjamin
ED - Wintergerst, Theresia
ID - 26874
SN - 978-3-7799-3869-9
T2 - Wörterbuch. Soziale Arbeit
TI - Wörterbuch. Soziale Arbeit
ER -
TY - JOUR
AB - Abstract
Purpose
To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood.
Methods
Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses.
Results
On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (Ptrend = 0.02) and FLI (Ptrend = 0.03). On the urinary excretion level, however, a higher FE (Ptrend = 0.03) and FE + SE (Ptrend = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI.
Conclusion
The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted.
AU - Perrar, Ines
AU - Buyken, Anette
AU - Penczynski, Katharina J.
AU - Remer, Thomas
AU - Kuhnle, Gunter G.
AU - Herder, Christian
AU - Roden, Michael
AU - Della Corte, Karen
AU - Nöthlings, Ute
AU - Alexy, Ute
ID - 27007
JF - European Journal of Nutrition
SN - 1436-6207
TI - Relevance of fructose intake in adolescence for fatty liver indices in young adulthood
ER -
TY - JOUR
AB - Purpose: To examine the prospective relevance of dietary sugar intake (based on dietary data as well as urinary excretion data) in adolescent years for insulin sensitivity and biomarkers of inflammation in young adulthood.Methods: Overall 254 participants of the DONALD study who had at least two 3-day weighed dietary records for calculating intakes of fructose, glucose, sucrose, total, free, added sugars, total sugars from sugar-sweetened beverages (SSB), juice, and sweets/sugar or at least two complete 24 h urine samples (n = 221) for calculating sugar excretion (urinary fructose and urinary fructose + sucrose) in adolescence (females: 9–15 years, males: 10–16 years) and a fasting blood sample in adulthood (18–36 years), were included in multivariable linear regression analyses assessing their prospective associations with adult homeostasis model assessment insulin sensitivity (HOMA2-%S) and a pro-inflammatory score (based on CRP, IL-6, IL-18, leptin, chemerin, adiponectin).Results: On the dietary intake level, no prospective associations were observed between adolescent fructose, sucrose, glucose, added, free, total sugar, or total sugar from SSB, juice or sweets/sugar intake and adult HOMA2-%S (p > 0.01). On the urinary level, however, higher excreted fructose levels were associated with improved adult HOMA2-%S (p = 0.008) among females only. No associations were observed between dietary or urinary sugars and the adult pro-inflammatory score (p > 0.01).Conclusion: The present study did not provide support that dietary sugar consumed in adolescence is associated with adult insulin sensitivity. The one potential exception was the moderate dietary consumption of fructose, which showed a beneficial association with adult fasting insulin and insulin sensitivity.
AU - Della Corte, Karen A.
AU - Penczynski, Katharina
AU - Kuhnle, Gunter
AU - Perrar, Ines
AU - Herder, Christian
AU - Roden, Michael
AU - Wudy, Stefan A.
AU - Remer, Thomas
AU - Alexy, Ute
AU - Buyken, Anette
ID - 27014
JF - Frontiers in Nutrition
SN - 2296-861X
TI - The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood
ER -
TY - JOUR
AB - Abstract
Background/objectives
Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence.
Subjects/methods
We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9–17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (N = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m2)]) and Fat Mass Index (FMI) [kg/m2)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at <12 years, ≥12 to ≤15 years and >15 years).
Results
Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01–0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01–0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003–0.08). Associations were stronger for the age group ≥12 to ≤15 years (p for interaction: <0.001). No relationship was found with FFMI.
Conclusions
Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness.
AU - Jankovic, Nicole
AU - Schmitting, Sarah
AU - Krüger, Bettina
AU - Nöthlings, Ute
AU - Buyken, Anette E.
AU - Alexy, Ute
ID - 27114
JF - European Journal of Clinical Nutrition
SN - 0954-3007
TI - Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study
ER -
TY - JOUR
AB - Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt.
AU - Hirtz, Raphael
AU - Zheng, Yiran
AU - Rajcsanyi, Luisa S.
AU - Libuda, Lars
AU - Antel, Jochen
AU - Peters, Triinu
AU - Hebebrand, Johannes
AU - Hinney, Anke
ID - 27572
JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
SN - 1422-4917
TI - Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts
ER -
TY - JOUR
AB - Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung.
AU - Libuda, Lars
AU - Hebebrand, Johannes
AU - Föcker, Manuel
AU - Peters, Triinu
AU - Hinney, Anke
ID - 27573
JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
SN - 1422-4917
TI - Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken
ER -
TY - JOUR
AB - In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = <.001, d = 1.35, large effect size, and p = <.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults.
AU - Hirtz, Raphael
AU - Libuda, Lars
AU - Hinney, Anke
AU - Föcker, Manuel
AU - Bühlmeier, Judith
AU - Antel, Jochen
AU - Holterhus, Paul-Martin
AU - Kulle, Alexandra
AU - Kiewert, Cordula
AU - Hebebrand, Johannes
AU - Grasemann, Corinna
ID - 27574
JF - Frontiers in Endocrinology
SN - 1664-2392
TI - Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression
ER -
TY - JOUR
AU - Zhang, Xiao
AU - Gong, Yunhui
AU - Della Corte, Karen
AU - Yu, Dianke
AU - Xue, Hongmei
AU - Shan, Shufang
AU - Tian, Guo
AU - Liang, Yi
AU - Zhang, Jieyi
AU - He, Fang
AU - Yang, Dagang
AU - Zhou, Rong
AU - Bao, Wei
AU - Buyken, Anette
AU - Cheng, Guo
ID - 27746
JF - Clinical Nutrition
SN - 0261-5614
TI - Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis
ER -
TY - JOUR
AU - Nyasordzi, Juliana
AU - Conrad, Johanna
AU - Goletzke, Janina
AU - Ludwig-Walz, Helena
AU - Herder, Christian
AU - Roden, Michael
AU - Wudy, Stefan A.
AU - Hua, Yifan
AU - Remer, Thomas
AU - Buyken, Anette
ID - 27790
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
TI - Early life factors and their relevance for markers of cardiometabolic risk in early adulthood
ER -