---
_id: '36062'
author:
- first_name: Kirsten
full_name: Schlegel-Matthies, Kirsten
id: '459'
last_name: Schlegel-Matthies
- first_name: Barbara
full_name: Methfessel, Barbara
last_name: Methfessel
citation:
ama: 'Schlegel-Matthies K, Methfessel B. Alltagskultur: viel beschworen, wenig
wissenschaftlich durchdrungen?! Hauswirtschaft und Wissenschaft. 2014;52(1):27-38.'
apa: 'Schlegel-Matthies, K., & Methfessel, B. (2014). Alltagskultur: viel beschworen,
wenig wissenschaftlich durchdrungen?! Hauswirtschaft und Wissenschaft,
52(1), 27–38.'
bibtex: '@article{Schlegel-Matthies_Methfessel_2014, title={ Alltagskultur: viel
beschworen, wenig wissenschaftlich durchdrungen?!}, volume={52}, number={1}, journal={Hauswirtschaft
und Wissenschaft}, author={Schlegel-Matthies, Kirsten and Methfessel, Barbara},
year={2014}, pages={27–38} }'
chicago: 'Schlegel-Matthies, Kirsten, and Barbara Methfessel. “ Alltagskultur: viel
beschworen, wenig wissenschaftlich durchdrungen?!” Hauswirtschaft und Wissenschaft
52, no. 1 (2014): 27–38.'
ieee: 'K. Schlegel-Matthies and B. Methfessel, “ Alltagskultur: viel beschworen,
wenig wissenschaftlich durchdrungen?!,” Hauswirtschaft und Wissenschaft,
vol. 52, no. 1, pp. 27–38, 2014.'
mla: 'Schlegel-Matthies, Kirsten, and Barbara Methfessel. “ Alltagskultur: viel
beschworen, wenig wissenschaftlich durchdrungen?!” Hauswirtschaft und Wissenschaft,
vol. 52, no. 1, 2014, pp. 27–38.'
short: K. Schlegel-Matthies, B. Methfessel, Hauswirtschaft und Wissenschaft 52 (2014)
27–38.
date_created: 2023-01-11T11:37:19Z
date_updated: 2023-01-11T11:37:24Z
department:
- _id: '35'
- _id: '17'
- _id: '22'
- _id: '396'
intvolume: ' 52'
issue: '1'
language:
- iso: ger
page: 27-38
publication: Hauswirtschaft und Wissenschaft
publication_status: published
status: public
title: ' Alltagskultur: viel beschworen, wenig wissenschaftlich durchdrungen?!'
type: journal_article
user_id: '459'
volume: 52
year: '2014'
...
---
_id: '54943'
abstract:
- lang: eng
text: Proteolytic activation is a unique feature of the epithelial sodium channel
(ENaC). However, the underlying molecular mechanisms and the physiologically relevant
proteases remain to be identified. The serine protease trypsin I can activate
ENaC in vitro but is unlikely to be the physiologically relevant activating protease
in ENaC-expressing tissues in vivo. Herein, we investigated whether human trypsin
IV, a form of trypsin that is co-expressed in several extrapancreatic epithelial
cells with ENaC, can activate human ENaC. In Xenopus laevis oocytes, we monitored
proteolytic activation of ENaC currents and the appearance of $\gamma$ENaC cleavage
products at the cell surface. We demonstrated that trypsin IV and trypsin I can
stimulate ENaC heterologously expressed in oocytes. ENaC cleavage and activation
by trypsin IV but not by trypsin I required a critical cleavage site (Lys-189)
in the extracellular domain of the $\gamma$-subunit. In contrast, channel activation
by trypsin I was prevented by mutating three putative cleavage sites (Lys-168,
Lys-170, and Arg-172) in addition to mutating previously described prostasin (RKRK(178)),
plasmin (Lys-189), and neutrophil elastase (Val-182 and Val-193) sites. Moreover,
we found that trypsin IV is expressed in human renal epithelial cells and can
increase ENaC-mediated sodium transport in cultured human airway epithelial cells.
Thus, trypsin IV may regulate ENaC function in epithelial tissues. Our results
show, for the first time, that trypsin IV can stimulate ENaC and that trypsin
IV and trypsin I activate ENaC by cleavage at distinct sites. The presence of
distinct cleavage sites may be important for ENaC regulation by tissue-specific
proteases.
author:
- first_name: Silke
full_name: Haerteis, Silke
last_name: Haerteis
- first_name: Annabel
full_name: Krappitz, Annabel
last_name: Krappitz
- first_name: Matteus
full_name: Krappitz, Matteus
last_name: Krappitz
- first_name: Jane E.
full_name: Murphy, Jane E.
last_name: Murphy
- first_name: Marko
full_name: Bertog, Marko
last_name: Bertog
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Regina
full_name: Nacken, Regina
last_name: Nacken
- first_name: Hyunjae
full_name: Chung, Hyunjae
last_name: Chung
- first_name: Morley D.
full_name: Hollenberg, Morley D.
last_name: Hollenberg
- first_name: Wolfgang
full_name: Knecht, Wolfgang
last_name: Knecht
- first_name: Nigel W.
full_name: Bunnett, Nigel W.
last_name: Bunnett
- first_name: Christoph
full_name: Korbmacher, Christoph
last_name: Korbmacher
citation:
ama: Haerteis S, Krappitz A, Krappitz M, et al. Proteolytic Activation of the Human
Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage
Sites. Journal of Biological Chemistry. 2014;289(27):19067–19078. doi:10.1074/jbc.m113.538470
apa: Haerteis, S., Krappitz, A., Krappitz, M., Murphy, J. E., Bertog, M., Krueger,
B., Nacken, R., Chung, H., Hollenberg, M. D., Knecht, W., Bunnett, N. W., &
Korbmacher, C. (2014). Proteolytic Activation of the Human Epithelial Sodium Channel
by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites. Journal of Biological
Chemistry, 289(27), 19067–19078. https://doi.org/10.1074/jbc.m113.538470
bibtex: '@article{Haerteis_Krappitz_Krappitz_Murphy_Bertog_Krueger_Nacken_Chung_Hollenberg_Knecht_et
al._2014, title={Proteolytic Activation of the Human Epithelial Sodium Channel
by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites}, volume={289}, DOI={10.1074/jbc.m113.538470}, number={27},
journal={Journal of Biological Chemistry}, publisher={Elsevier}, author={Haerteis,
Silke and Krappitz, Annabel and Krappitz, Matteus and Murphy, Jane E. and Bertog,
Marko and Krueger, Bettina and Nacken, Regina and Chung, Hyunjae and Hollenberg,
Morley D. and Knecht, Wolfgang and et al.}, year={2014}, pages={19067–19078} }'
chicago: 'Haerteis, Silke, Annabel Krappitz, Matteus Krappitz, Jane E. Murphy, Marko
Bertog, Bettina Krueger, Regina Nacken, et al. “Proteolytic Activation of the
Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct
Cleavage Sites.” Journal of Biological Chemistry 289, no. 27 (2014): 19067–19078.
https://doi.org/10.1074/jbc.m113.538470.'
ieee: 'S. Haerteis et al., “Proteolytic Activation of the Human Epithelial
Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites,”
Journal of Biological Chemistry, vol. 289, no. 27, pp. 19067–19078, 2014,
doi: 10.1074/jbc.m113.538470.'
mla: Haerteis, Silke, et al. “Proteolytic Activation of the Human Epithelial Sodium
Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites.” Journal
of Biological Chemistry, vol. 289, no. 27, Elsevier, 2014, pp. 19067–19078,
doi:10.1074/jbc.m113.538470.
short: S. Haerteis, A. Krappitz, M. Krappitz, J.E. Murphy, M. Bertog, B. Krueger,
R. Nacken, H. Chung, M.D. Hollenberg, W. Knecht, N.W. Bunnett, C. Korbmacher,
Journal of Biological Chemistry 289 (2014) 19067–19078.
date_created: 2024-06-30T13:57:24Z
date_updated: 2024-06-30T13:57:37Z
department:
- _id: '35'
- _id: '22'
doi: 10.1074/jbc.m113.538470
intvolume: ' 289'
issue: '27'
language:
- iso: eng
page: 19067–19078
publication: Journal of Biological Chemistry
publisher: Elsevier
status: public
title: Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV
and Trypsin I Involves Distinct Cleavage Sites
type: journal_article
user_id: '49428'
volume: 289
year: '2014'
...
---
_id: '40219'
author:
- first_name: Inga
full_name: Wagenknecht, Inga
id: '98804'
last_name: Wagenknecht
- first_name: Uta
full_name: Meier-Gräwe, Uta
last_name: Meier-Gräwe
citation:
ama: Wagenknecht I, Meier-Gräwe U. Auf- und Ausbau Früher Hilfen in Zeiten knapper
öffentlicher Kassen. Warum es sich lohnt, in Frühe Hilfen zu investieren. Zeitschrift
für Paar-, Familien- und Sozialtherapie. 2014;15(2):91-108.
apa: Wagenknecht, I., & Meier-Gräwe, U. (2014). Auf- und Ausbau Früher Hilfen
in Zeiten knapper öffentlicher Kassen. Warum es sich lohnt, in Frühe Hilfen zu
investieren. Zeitschrift für Paar-, Familien- und Sozialtherapie, 15(2),
91–108.
bibtex: '@article{Wagenknecht_Meier-Gräwe_2014, title={Auf- und Ausbau Früher Hilfen
in Zeiten knapper öffentlicher Kassen. Warum es sich lohnt, in Frühe Hilfen zu
investieren}, volume={15}, number={2}, journal={Zeitschrift für Paar-, Familien-
und Sozialtherapie}, publisher={Psychosozial-Verlag}, author={Wagenknecht, Inga
and Meier-Gräwe, Uta}, year={2014}, pages={91–108} }'
chicago: 'Wagenknecht, Inga, and Uta Meier-Gräwe. “Auf- und Ausbau Früher Hilfen
in Zeiten knapper öffentlicher Kassen. Warum es sich lohnt, in Frühe Hilfen zu
investieren.” Zeitschrift für Paar-, Familien- und Sozialtherapie 15, no.
2 (2014): 91–108.'
ieee: I. Wagenknecht and U. Meier-Gräwe, “Auf- und Ausbau Früher Hilfen in Zeiten
knapper öffentlicher Kassen. Warum es sich lohnt, in Frühe Hilfen zu investieren,”
Zeitschrift für Paar-, Familien- und Sozialtherapie, vol. 15, no. 2, pp.
91–108, 2014.
mla: Wagenknecht, Inga, and Uta Meier-Gräwe. “Auf- und Ausbau Früher Hilfen in Zeiten
knapper öffentlicher Kassen. Warum es sich lohnt, in Frühe Hilfen zu investieren.”
Zeitschrift für Paar-, Familien- und Sozialtherapie, vol. 15, no. 2, Psychosozial-Verlag,
2014, pp. 91–108.
short: I. Wagenknecht, U. Meier-Gräwe, Zeitschrift für Paar-, Familien- und Sozialtherapie
15 (2014) 91–108.
date_created: 2023-01-26T09:13:06Z
date_updated: 2023-01-26T09:13:37Z
department:
- _id: '22'
intvolume: ' 15'
issue: '2'
language:
- iso: ger
page: 91-108
publication: Zeitschrift für Paar-, Familien- und Sozialtherapie
publication_identifier:
issn:
- 1616-8836
publication_status: published
publisher: Psychosozial-Verlag
status: public
title: Auf- und Ausbau Früher Hilfen in Zeiten knapper öffentlicher Kassen. Warum
es sich lohnt, in Frühe Hilfen zu investieren
type: journal_article
user_id: '50419'
volume: 15
year: '2014'
...
---
_id: '26910'
abstract:
- lang: eng
text: Non-alcoholic fatty liver disease (NAFLD) is closely associated with
insulin resistance and obesity. Hence, carbohydrate quality could be of relevance
to the risk of NAFLD, but prospective data are lacking. The aim of the present
study was to investigate longitudinal associations between carbohydrate quality
(including dietary glycaemic index (GI) and intakes of sugar, starch and fibre)
and markers of liver function in an older Australian population. The analysis
was based on 866 participants ( ≥ 49 years) of the Blue Mountains Eye Study with
fasting blood specimens and dietary intake data at baseline and 5-year follow-up.
Multi-level mixed regression analysis was used to relate dietary GI and sugar,
starch and fibre intake to the liver enzymes alanine aminotransferase (ALT) and
γ-glutamyltransferase (GGT), as well as fasting TAG and HDL-cholesterol (HDL-C).
After adjustment for potential confounding factors, a lower fibre intake was cross-sectionally
related to higher GGT (P= 0·02) and fasting TAG (P= 0·002)
levels, with fruit fibre being the most relevant fibre source (P= 0·095
for GGT; P= 0·003 for TAG). A higher dietary GI was
associated with lower HDL-C (P= 0·046). Changes in
carbohydrate quality during 5 years were not related to changes in ALT, GGT, TAG
or HDL-C (P≥ 0·08). In conclusion, the absence of longitudinal
associations between carbohydrate quality and liver enzymes and serum lipids in
this older population does not support a major role of carbohydrate nutrition
in liver function among the elderly.
author:
- first_name: Janina
full_name: Goletzke, Janina
last_name: Goletzke
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
- first_name: Bamini
full_name: Gopinath, Bamini
last_name: Gopinath
- first_name: Elena
full_name: Rochtchina, Elena
last_name: Rochtchina
- first_name: Alan W.
full_name: Barclay, Alan W.
last_name: Barclay
- first_name: Guo
full_name: Cheng, Guo
last_name: Cheng
- first_name: Jennie C.
full_name: Brand-Miller, Jennie C.
last_name: Brand-Miller
- first_name: Paul
full_name: Mitchell, Paul
last_name: Mitchell
citation:
ama: Goletzke J, Buyken A, Gopinath B, et al. Carbohydrate quality is not associated
with liver enzyme activity and plasma TAG and HDL concentrations over 5 years
in an older population. British Journal of Nutrition. Published online
2013:918-925. doi:10.1017/s0007114512005867
apa: Goletzke, J., Buyken, A., Gopinath, B., Rochtchina, E., Barclay, A. W., Cheng,
G., Brand-Miller, J. C., & Mitchell, P. (2013). Carbohydrate quality is not
associated with liver enzyme activity and plasma TAG and HDL concentrations over
5 years in an older population. British Journal of Nutrition, 918–925.
https://doi.org/10.1017/s0007114512005867
bibtex: '@article{Goletzke_Buyken_Gopinath_Rochtchina_Barclay_Cheng_Brand-Miller_Mitchell_2013,
title={Carbohydrate quality is not associated with liver enzyme activity and plasma
TAG and HDL concentrations over 5 years in an older population}, DOI={10.1017/s0007114512005867},
journal={British Journal of Nutrition}, author={Goletzke, Janina and Buyken, Anette
and Gopinath, Bamini and Rochtchina, Elena and Barclay, Alan W. and Cheng, Guo
and Brand-Miller, Jennie C. and Mitchell, Paul}, year={2013}, pages={918–925}
}'
chicago: Goletzke, Janina, Anette Buyken, Bamini Gopinath, Elena Rochtchina, Alan
W. Barclay, Guo Cheng, Jennie C. Brand-Miller, and Paul Mitchell. “Carbohydrate
Quality Is Not Associated with Liver Enzyme Activity and Plasma TAG and HDL Concentrations
over 5 Years in an Older Population.” British Journal of Nutrition, 2013,
918–25. https://doi.org/10.1017/s0007114512005867.
ieee: 'J. Goletzke et al., “Carbohydrate quality is not associated with liver
enzyme activity and plasma TAG and HDL concentrations over 5 years in an older
population,” British Journal of Nutrition, pp. 918–925, 2013, doi: 10.1017/s0007114512005867.'
mla: Goletzke, Janina, et al. “Carbohydrate Quality Is Not Associated with Liver
Enzyme Activity and Plasma TAG and HDL Concentrations over 5 Years in an Older
Population.” British Journal of Nutrition, 2013, pp. 918–25, doi:10.1017/s0007114512005867.
short: J. Goletzke, A. Buyken, B. Gopinath, E. Rochtchina, A.W. Barclay, G. Cheng,
J.C. Brand-Miller, P. Mitchell, British Journal of Nutrition (2013) 918–925.
date_created: 2021-10-26T14:11:22Z
date_updated: 2022-01-06T06:57:30Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.1017/s0007114512005867
language:
- iso: eng
page: 918-925
publication: British Journal of Nutrition
publication_identifier:
issn:
- 0007-1145
- 1475-2662
publication_status: published
status: public
title: Carbohydrate quality is not associated with liver enzyme activity and plasma
TAG and HDL concentrations over 5 years in an older population
type: journal_article
user_id: '61597'
year: '2013'
...
---
_id: '26911'
author:
- first_name: J.
full_name: Goletzke, J.
last_name: Goletzke
- first_name: C.
full_name: Herder, C.
last_name: Herder
- first_name: G.
full_name: Joslowski, G.
last_name: Joslowski
- first_name: K.
full_name: Bolzenius, K.
last_name: Bolzenius
- first_name: T.
full_name: Remer, T.
last_name: Remer
- first_name: S. A.
full_name: Wudy, S. A.
last_name: Wudy
- first_name: M.
full_name: Roden, M.
last_name: Roden
- first_name: W.
full_name: Rathmann, W.
last_name: Rathmann
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
citation:
ama: Goletzke J, Herder C, Joslowski G, et al. Habitually Higher Dietary Glycemic
Index During Puberty Is Prospectively Related to Increased Risk Markers of Type
2 Diabetes in Younger Adulthood. Diabetes Care. Published online 2013:1870-1876.
doi:10.2337/dc12-2063
apa: Goletzke, J., Herder, C., Joslowski, G., Bolzenius, K., Remer, T., Wudy, S.
A., Roden, M., Rathmann, W., & Buyken, A. (2013). Habitually Higher Dietary
Glycemic Index During Puberty Is Prospectively Related to Increased Risk Markers
of Type 2 Diabetes in Younger Adulthood. Diabetes Care, 1870–1876. https://doi.org/10.2337/dc12-2063
bibtex: '@article{Goletzke_Herder_Joslowski_Bolzenius_Remer_Wudy_Roden_Rathmann_Buyken_2013,
title={Habitually Higher Dietary Glycemic Index During Puberty Is Prospectively
Related to Increased Risk Markers of Type 2 Diabetes in Younger Adulthood}, DOI={10.2337/dc12-2063}, journal={Diabetes
Care}, author={Goletzke, J. and Herder, C. and Joslowski, G. and Bolzenius, K.
and Remer, T. and Wudy, S. A. and Roden, M. and Rathmann, W. and Buyken, Anette},
year={2013}, pages={1870–1876} }'
chicago: Goletzke, J., C. Herder, G. Joslowski, K. Bolzenius, T. Remer, S. A. Wudy,
M. Roden, W. Rathmann, and Anette Buyken. “Habitually Higher Dietary Glycemic
Index During Puberty Is Prospectively Related to Increased Risk Markers of Type
2 Diabetes in Younger Adulthood.” Diabetes Care, 2013, 1870–76. https://doi.org/10.2337/dc12-2063.
ieee: 'J. Goletzke et al., “Habitually Higher Dietary Glycemic Index During
Puberty Is Prospectively Related to Increased Risk Markers of Type 2 Diabetes
in Younger Adulthood,” Diabetes Care, pp. 1870–1876, 2013, doi: 10.2337/dc12-2063.'
mla: Goletzke, J., et al. “Habitually Higher Dietary Glycemic Index During Puberty
Is Prospectively Related to Increased Risk Markers of Type 2 Diabetes in Younger
Adulthood.” Diabetes Care, 2013, pp. 1870–76, doi:10.2337/dc12-2063.
short: J. Goletzke, C. Herder, G. Joslowski, K. Bolzenius, T. Remer, S.A. Wudy,
M. Roden, W. Rathmann, A. Buyken, Diabetes Care (2013) 1870–1876.
date_created: 2021-10-26T14:12:55Z
date_updated: 2022-01-06T06:57:30Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.2337/dc12-2063
language:
- iso: eng
page: 1870-1876
publication: Diabetes Care
publication_identifier:
issn:
- 0149-5992
- 1935-5548
publication_status: published
status: public
title: Habitually Higher Dietary Glycemic Index During Puberty Is Prospectively Related
to Increased Risk Markers of Type 2 Diabetes in Younger Adulthood
type: journal_article
user_id: '61597'
year: '2013'
...
---
_id: '26912'
author:
- first_name: Gesa
full_name: Joslowski, Gesa
last_name: Joslowski
- first_name: Thomas
full_name: Remer, Thomas
last_name: Remer
- first_name: Karen E.
full_name: Assmann, Karen E.
last_name: Assmann
- first_name: Danika
full_name: Krupp, Danika
last_name: Krupp
- first_name: Guo
full_name: Cheng, Guo
last_name: Cheng
- first_name: Sarah P.
full_name: Garnett, Sarah P.
last_name: Garnett
- first_name: Anja
full_name: Kroke, Anja
last_name: Kroke
- first_name: Stefan A.
full_name: Wudy, Stefan A.
last_name: Wudy
- first_name: Anke L. B.
full_name: Günther, Anke L. B.
last_name: Günther
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
citation:
ama: Joslowski G, Remer T, Assmann KE, et al. Animal Protein Intakes during Early
Life and Adolescence Differ in Their Relation to the Growth Hormone-Insulin-Like-Growth-Factor
Axis in Young Adulthood. The Journal of Nutrition. Published online 2013:1147-1154.
doi:10.3945/jn.113.175877
apa: Joslowski, G., Remer, T., Assmann, K. E., Krupp, D., Cheng, G., Garnett, S.
P., Kroke, A., Wudy, S. A., Günther, A. L. B., & Buyken, A. (2013). Animal
Protein Intakes during Early Life and Adolescence Differ in Their Relation to
the Growth Hormone-Insulin-Like-Growth-Factor Axis in Young Adulthood. The
Journal of Nutrition, 1147–1154. https://doi.org/10.3945/jn.113.175877
bibtex: '@article{Joslowski_Remer_Assmann_Krupp_Cheng_Garnett_Kroke_Wudy_Günther_Buyken_2013,
title={Animal Protein Intakes during Early Life and Adolescence Differ in Their
Relation to the Growth Hormone-Insulin-Like-Growth-Factor Axis in Young Adulthood},
DOI={10.3945/jn.113.175877},
journal={The Journal of Nutrition}, author={Joslowski, Gesa and Remer, Thomas
and Assmann, Karen E. and Krupp, Danika and Cheng, Guo and Garnett, Sarah P. and
Kroke, Anja and Wudy, Stefan A. and Günther, Anke L. B. and Buyken, Anette}, year={2013},
pages={1147–1154} }'
chicago: Joslowski, Gesa, Thomas Remer, Karen E. Assmann, Danika Krupp, Guo Cheng,
Sarah P. Garnett, Anja Kroke, Stefan A. Wudy, Anke L. B. Günther, and Anette Buyken.
“Animal Protein Intakes during Early Life and Adolescence Differ in Their Relation
to the Growth Hormone-Insulin-Like-Growth-Factor Axis in Young Adulthood.” The
Journal of Nutrition, 2013, 1147–54. https://doi.org/10.3945/jn.113.175877.
ieee: 'G. Joslowski et al., “Animal Protein Intakes during Early Life and
Adolescence Differ in Their Relation to the Growth Hormone-Insulin-Like-Growth-Factor
Axis in Young Adulthood,” The Journal of Nutrition, pp. 1147–1154, 2013,
doi: 10.3945/jn.113.175877.'
mla: Joslowski, Gesa, et al. “Animal Protein Intakes during Early Life and Adolescence
Differ in Their Relation to the Growth Hormone-Insulin-Like-Growth-Factor Axis
in Young Adulthood.” The Journal of Nutrition, 2013, pp. 1147–54, doi:10.3945/jn.113.175877.
short: G. Joslowski, T. Remer, K.E. Assmann, D. Krupp, G. Cheng, S.P. Garnett, A.
Kroke, S.A. Wudy, A.L.B. Günther, A. Buyken, The Journal of Nutrition (2013) 1147–1154.
date_created: 2021-10-26T14:15:43Z
date_updated: 2022-01-06T06:57:30Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.3945/jn.113.175877
language:
- iso: eng
page: 1147-1154
publication: The Journal of Nutrition
publication_identifier:
issn:
- 1541-6100
- 0022-3166
publication_status: published
status: public
title: Animal Protein Intakes during Early Life and Adolescence Differ in Their Relation
to the Growth Hormone-Insulin-Like-Growth-Factor Axis in Young Adulthood
type: journal_article
user_id: '61597'
year: '2013'
...
---
_id: '27043'
abstract:
- lang: eng
text: Dietary fat intake in childhood may influence the risk for developing
chronic diseases. The objective of the present study was to examine secular trends
in the parameters of fat intake between 2000 and 2010 in a sample of German children
and adolescents (n 808) participating in the Dortmund
Nutritional and Anthropometric Longitudinally Designed (DONALD) Study. Dietary
data from 4380 3 d weighed dietary records were analysed using repeated-measures
regression to determine time trends in fat quantity, i.e. the intake of total
fat, and in fat quality, i.e. the ratios of SFA, MUFA and PUFA. In young children
(2–3 years) and in adolescents (13–18 years), total fat intake remained stable
over time, but decreased by 0·08 % of total energy (%E) per year in 4–12-year-old
children. In 2010, median fat intake was at the upper end of the recommendations.
SFA intake decreased slightly in 2–3- and 4–12-year-old children by 0·09 and 0·05 %E
per year, respectively. MUFA and PUFA intakes remained stable in all the age groups
except in adolescents. Here, PUFA intake decreased initially, but increased between
2005 and 2010. In 2010, only between 3 and 18 % of the respective age groups had
an intake of SFA or PUFA within the recommendations. In conclusion, fat quantity
and quality did not change substantially between 2000 and 2010. Fat quality, in
particular, needs to be improved, since a large percentage of our sample did not
meet the recommended intakes for SFA and PUFA.
author:
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: Ute
full_name: Alexy, Ute
last_name: Alexy
- first_name: Mathilde
full_name: Kersting, Mathilde
last_name: Kersting
citation:
ama: 'Libuda L, Alexy U, Kersting M. Time trends in dietary fat intake in a sample
of German children and adolescents between 2000 and 2010: not quantity, but quality
is the issue. British Journal of Nutrition. Published online 2013:141-150.
doi:10.1017/s0007114513002031'
apa: 'Libuda, L., Alexy, U., & Kersting, M. (2013). Time trends in dietary fat
intake in a sample of German children and adolescents between 2000 and 2010: not
quantity, but quality is the issue. British Journal of Nutrition, 141–150.
https://doi.org/10.1017/s0007114513002031'
bibtex: '@article{Libuda_Alexy_Kersting_2013, title={Time trends in dietary fat
intake in a sample of German children and adolescents between 2000 and 2010: not
quantity, but quality is the issue}, DOI={10.1017/s0007114513002031},
journal={British Journal of Nutrition}, author={Libuda, Lars and Alexy, Ute and
Kersting, Mathilde}, year={2013}, pages={141–150} }'
chicago: 'Libuda, Lars, Ute Alexy, and Mathilde Kersting. “Time Trends in Dietary
Fat Intake in a Sample of German Children and Adolescents between 2000 and 2010:
Not Quantity, but Quality Is the Issue.” British Journal of Nutrition,
2013, 141–50. https://doi.org/10.1017/s0007114513002031.'
ieee: 'L. Libuda, U. Alexy, and M. Kersting, “Time trends in dietary fat intake
in a sample of German children and adolescents between 2000 and 2010: not quantity,
but quality is the issue,” British Journal of Nutrition, pp. 141–150, 2013,
doi: 10.1017/s0007114513002031.'
mla: 'Libuda, Lars, et al. “Time Trends in Dietary Fat Intake in a Sample of German
Children and Adolescents between 2000 and 2010: Not Quantity, but Quality Is the
Issue.” British Journal of Nutrition, 2013, pp. 141–50, doi:10.1017/s0007114513002031.'
short: L. Libuda, U. Alexy, M. Kersting, British Journal of Nutrition (2013) 141–150.
date_created: 2021-11-01T20:17:51Z
date_updated: 2022-01-06T06:57:32Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.1017/s0007114513002031
language:
- iso: eng
page: 141-150
publication: British Journal of Nutrition
publication_identifier:
issn:
- 0007-1145
- 1475-2662
publication_status: published
status: public
title: 'Time trends in dietary fat intake in a sample of German children and adolescents
between 2000 and 2010: not quantity, but quality is the issue'
type: journal_article
user_id: '49428'
year: '2013'
...
---
_id: '27061'
author:
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: Madlen
full_name: Stimming, Madlen
last_name: Stimming
- first_name: Christina
full_name: Mesch, Christina
last_name: Mesch
- first_name: Petra
full_name: Warschburger, Petra
last_name: Warschburger
- first_name: Hermann
full_name: Kalhoff, Hermann
last_name: Kalhoff
- first_name: Berthold Viktor
full_name: Koletzko, Berthold Viktor
last_name: Koletzko
- first_name: Mathilde
full_name: Kersting, Mathilde
last_name: Kersting
citation:
ama: Libuda L, Stimming M, Mesch C, et al. Frequencies and demographic determinants
of breastfeeding and DHA supplementation in a nationwide sample of mothers in
Germany. European Journal of Nutrition. Published online 2013:1335-1344.
doi:10.1007/s00394-013-0633-4
apa: Libuda, L., Stimming, M., Mesch, C., Warschburger, P., Kalhoff, H., Koletzko,
B. V., & Kersting, M. (2013). Frequencies and demographic determinants of
breastfeeding and DHA supplementation in a nationwide sample of mothers in Germany.
European Journal of Nutrition, 1335–1344. https://doi.org/10.1007/s00394-013-0633-4
bibtex: '@article{Libuda_Stimming_Mesch_Warschburger_Kalhoff_Koletzko_Kersting_2013,
title={Frequencies and demographic determinants of breastfeeding and DHA supplementation
in a nationwide sample of mothers in Germany}, DOI={10.1007/s00394-013-0633-4},
journal={European Journal of Nutrition}, author={Libuda, Lars and Stimming, Madlen
and Mesch, Christina and Warschburger, Petra and Kalhoff, Hermann and Koletzko,
Berthold Viktor and Kersting, Mathilde}, year={2013}, pages={1335–1344} }'
chicago: Libuda, Lars, Madlen Stimming, Christina Mesch, Petra Warschburger, Hermann
Kalhoff, Berthold Viktor Koletzko, and Mathilde Kersting. “Frequencies and Demographic
Determinants of Breastfeeding and DHA Supplementation in a Nationwide Sample of
Mothers in Germany.” European Journal of Nutrition, 2013, 1335–44. https://doi.org/10.1007/s00394-013-0633-4.
ieee: 'L. Libuda et al., “Frequencies and demographic determinants of breastfeeding
and DHA supplementation in a nationwide sample of mothers in Germany,” European
Journal of Nutrition, pp. 1335–1344, 2013, doi: 10.1007/s00394-013-0633-4.'
mla: Libuda, Lars, et al. “Frequencies and Demographic Determinants of Breastfeeding
and DHA Supplementation in a Nationwide Sample of Mothers in Germany.” European
Journal of Nutrition, 2013, pp. 1335–44, doi:10.1007/s00394-013-0633-4.
short: L. Libuda, M. Stimming, C. Mesch, P. Warschburger, H. Kalhoff, B.V. Koletzko,
M. Kersting, European Journal of Nutrition (2013) 1335–1344.
date_created: 2021-11-02T20:22:36Z
date_updated: 2022-01-06T06:57:33Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.1007/s00394-013-0633-4
language:
- iso: eng
page: 1335-1344
publication: European Journal of Nutrition
publication_identifier:
issn:
- 1436-6207
- 1436-6215
publication_status: published
status: public
title: Frequencies and demographic determinants of breastfeeding and DHA supplementation
in a nationwide sample of mothers in Germany
type: journal_article
user_id: '49428'
year: '2013'
...
---
_id: '27062'
author:
- first_name: Katrin
full_name: Müller, Katrin
last_name: Müller
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: Katharina
full_name: Diethelm, Katharina
last_name: Diethelm
- first_name: Inge
full_name: Huybrechts, Inge
last_name: Huybrechts
- first_name: Luis A.
full_name: Moreno, Luis A.
last_name: Moreno
- first_name: Yannis
full_name: Manios, Yannis
last_name: Manios
- first_name: Lorenza
full_name: Mistura, Lorenza
last_name: Mistura
- first_name: Jean
full_name: Dallongeville, Jean
last_name: Dallongeville
- first_name: Anthony
full_name: Kafatos, Anthony
last_name: Kafatos
- first_name: Marcela
full_name: González-Gross, Marcela
last_name: González-Gross
- first_name: Magdalena
full_name: Cuenca-García, Magdalena
last_name: Cuenca-García
- first_name: Michael
full_name: Sjöström, Michael
last_name: Sjöström
- first_name: Lena
full_name: Hallström, Lena
last_name: Hallström
- first_name: Kurt
full_name: Widhalm, Kurt
last_name: Widhalm
- first_name: Mathilde
full_name: Kersting, Mathilde
last_name: Kersting
citation:
ama: Müller K, Libuda L, Diethelm K, et al. Lunch at school, at home or elsewhere.
Where do adolescents usually get it and what do they eat? Results of the HELENA
Study. Appetite. Published online 2013:332-339. doi:10.1016/j.appet.2013.09.002
apa: Müller, K., Libuda, L., Diethelm, K., Huybrechts, I., Moreno, L. A., Manios,
Y., Mistura, L., Dallongeville, J., Kafatos, A., González-Gross, M., Cuenca-García,
M., Sjöström, M., Hallström, L., Widhalm, K., & Kersting, M. (2013). Lunch
at school, at home or elsewhere. Where do adolescents usually get it and what
do they eat? Results of the HELENA Study. Appetite, 332–339. https://doi.org/10.1016/j.appet.2013.09.002
bibtex: '@article{Müller_Libuda_Diethelm_Huybrechts_Moreno_Manios_Mistura_Dallongeville_Kafatos_González-Gross_et
al._2013, title={Lunch at school, at home or elsewhere. Where do adolescents usually
get it and what do they eat? Results of the HELENA Study}, DOI={10.1016/j.appet.2013.09.002},
journal={Appetite}, author={Müller, Katrin and Libuda, Lars and Diethelm, Katharina
and Huybrechts, Inge and Moreno, Luis A. and Manios, Yannis and Mistura, Lorenza
and Dallongeville, Jean and Kafatos, Anthony and González-Gross, Marcela and et
al.}, year={2013}, pages={332–339} }'
chicago: Müller, Katrin, Lars Libuda, Katharina Diethelm, Inge Huybrechts, Luis
A. Moreno, Yannis Manios, Lorenza Mistura, et al. “Lunch at School, at Home or
Elsewhere. Where Do Adolescents Usually Get It and What Do They Eat? Results of
the HELENA Study.” Appetite, 2013, 332–39. https://doi.org/10.1016/j.appet.2013.09.002.
ieee: 'K. Müller et al., “Lunch at school, at home or elsewhere. Where do
adolescents usually get it and what do they eat? Results of the HELENA Study,”
Appetite, pp. 332–339, 2013, doi: 10.1016/j.appet.2013.09.002.'
mla: Müller, Katrin, et al. “Lunch at School, at Home or Elsewhere. Where Do Adolescents
Usually Get It and What Do They Eat? Results of the HELENA Study.” Appetite,
2013, pp. 332–39, doi:10.1016/j.appet.2013.09.002.
short: K. Müller, L. Libuda, K. Diethelm, I. Huybrechts, L.A. Moreno, Y. Manios,
L. Mistura, J. Dallongeville, A. Kafatos, M. González-Gross, M. Cuenca-García,
M. Sjöström, L. Hallström, K. Widhalm, M. Kersting, Appetite (2013) 332–339.
date_created: 2021-11-02T20:25:10Z
date_updated: 2022-01-06T06:57:33Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.1016/j.appet.2013.09.002
language:
- iso: eng
page: 332-339
publication: Appetite
publication_identifier:
issn:
- 0195-6663
publication_status: published
status: public
title: Lunch at school, at home or elsewhere. Where do adolescents usually get it
and what do they eat? Results of the HELENA Study
type: journal_article
user_id: '49428'
year: '2013'
...
---
_id: '27063'
author:
- first_name: K
full_name: Müller, K
last_name: Müller
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: N
full_name: Gawehn, N
last_name: Gawehn
- first_name: C
full_name: Drossard, C
last_name: Drossard
- first_name: K
full_name: Bolzenius, K
last_name: Bolzenius
- first_name: C
full_name: Kunz, C
last_name: Kunz
- first_name: M
full_name: Kersting, M
last_name: Kersting
citation:
ama: 'Müller K, Libuda L, Gawehn N, et al. Effects of lunch on children’s short-term
cognitive functioning: a randomized crossover study. European Journal of Clinical
Nutrition. Published online 2013:185-189. doi:10.1038/ejcn.2012.209'
apa: 'Müller, K., Libuda, L., Gawehn, N., Drossard, C., Bolzenius, K., Kunz, C.,
& Kersting, M. (2013). Effects of lunch on children’s short-term cognitive
functioning: a randomized crossover study. European Journal of Clinical Nutrition,
185–189. https://doi.org/10.1038/ejcn.2012.209'
bibtex: '@article{Müller_Libuda_Gawehn_Drossard_Bolzenius_Kunz_Kersting_2013, title={Effects
of lunch on children’s short-term cognitive functioning: a randomized crossover
study}, DOI={10.1038/ejcn.2012.209},
journal={European Journal of Clinical Nutrition}, author={Müller, K and Libuda,
Lars and Gawehn, N and Drossard, C and Bolzenius, K and Kunz, C and Kersting,
M}, year={2013}, pages={185–189} }'
chicago: 'Müller, K, Lars Libuda, N Gawehn, C Drossard, K Bolzenius, C Kunz, and
M Kersting. “Effects of Lunch on Children’s Short-Term Cognitive Functioning:
A Randomized Crossover Study.” European Journal of Clinical Nutrition,
2013, 185–89. https://doi.org/10.1038/ejcn.2012.209.'
ieee: 'K. Müller et al., “Effects of lunch on children’s short-term cognitive
functioning: a randomized crossover study,” European Journal of Clinical Nutrition,
pp. 185–189, 2013, doi: 10.1038/ejcn.2012.209.'
mla: 'Müller, K., et al. “Effects of Lunch on Children’s Short-Term Cognitive Functioning:
A Randomized Crossover Study.” European Journal of Clinical Nutrition,
2013, pp. 185–89, doi:10.1038/ejcn.2012.209.'
short: K. Müller, L. Libuda, N. Gawehn, C. Drossard, K. Bolzenius, C. Kunz, M. Kersting,
European Journal of Clinical Nutrition (2013) 185–189.
date_created: 2021-11-02T20:27:16Z
date_updated: 2022-01-06T06:57:33Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.1038/ejcn.2012.209
language:
- iso: eng
page: 185-189
publication: European Journal of Clinical Nutrition
publication_identifier:
issn:
- 0954-3007
- 1476-5640
publication_status: published
status: public
title: 'Effects of lunch on children’s short-term cognitive functioning: a randomized
crossover study'
type: journal_article
user_id: '49428'
year: '2013'
...
---
_id: '27514'
author:
- first_name: Anke
full_name: Oepping, Anke
last_name: Oepping
- first_name: Kirsten
full_name: Schlegel-Matthies, Kirsten
id: '459'
last_name: Schlegel-Matthies
citation:
ama: Oepping A, Schlegel-Matthies K. Bildung für nachhaltige Entwicklung. Den Alltag
gestalten – Teilhabe ermöglichen. Verbraucherbildung als Aufgabe von Schule. Schule
NRW Amtsblatt des Ministeriums für Schule und Weiterbildung. 2013;2:10-12.
apa: Oepping, A., & Schlegel-Matthies, K. (2013). Bildung für nachhaltige Entwicklung.
Den Alltag gestalten – Teilhabe ermöglichen. Verbraucherbildung als Aufgabe von
Schule. Schule NRW. Amtsblatt des Ministeriums für Schule und Weiterbildung,
2, 10–12.
bibtex: '@article{Oepping_Schlegel-Matthies_2013, title={Bildung für nachhaltige
Entwicklung. Den Alltag gestalten – Teilhabe ermöglichen. Verbraucherbildung als
Aufgabe von Schule}, volume={2}, journal={Schule NRW. Amtsblatt des Ministeriums
für Schule und Weiterbildung}, author={Oepping, Anke and Schlegel-Matthies, Kirsten},
year={2013}, pages={10–12} }'
chicago: 'Oepping, Anke, and Kirsten Schlegel-Matthies. “Bildung für nachhaltige
Entwicklung. Den Alltag gestalten – Teilhabe ermöglichen. Verbraucherbildung als
Aufgabe von Schule.” Schule NRW. Amtsblatt des Ministeriums für Schule und
Weiterbildung 2 (2013): 10–12.'
ieee: A. Oepping and K. Schlegel-Matthies, “Bildung für nachhaltige Entwicklung.
Den Alltag gestalten – Teilhabe ermöglichen. Verbraucherbildung als Aufgabe von
Schule,” Schule NRW. Amtsblatt des Ministeriums für Schule und Weiterbildung,
vol. 2, pp. 10–12, 2013.
mla: Oepping, Anke, and Kirsten Schlegel-Matthies. “Bildung für nachhaltige Entwicklung.
Den Alltag gestalten – Teilhabe ermöglichen. Verbraucherbildung als Aufgabe von
Schule.” Schule NRW. Amtsblatt des Ministeriums für Schule und Weiterbildung,
vol. 2, 2013, pp. 10–12.
short: A. Oepping, K. Schlegel-Matthies, Schule NRW. Amtsblatt des Ministeriums
für Schule und Weiterbildung 2 (2013) 10–12.
date_created: 2021-11-17T10:41:58Z
date_updated: 2022-01-06T06:57:40Z
department:
- _id: '35'
- _id: '22'
- _id: '396'
intvolume: ' 2'
language:
- iso: ger
page: 10 - 12
publication: Schule NRW. Amtsblatt des Ministeriums für Schule und Weiterbildung
publication_status: published
status: public
title: Bildung für nachhaltige Entwicklung. Den Alltag gestalten – Teilhabe ermöglichen.
Verbraucherbildung als Aufgabe von Schule
type: journal_article
user_id: '49428'
volume: 2
year: '2013'
...
---
_id: '27515'
author:
- first_name: Kirsten
full_name: Schlegel-Matthies, Kirsten
id: '459'
last_name: Schlegel-Matthies
citation:
ama: Schlegel-Matthies K. Ethik, Konsumentenverantwortung und Verbraucherbildung
im Spannungsfeld. Haushalt in Bildung und Forschung (HiBiFo). 2013;2(2):61-70.
apa: Schlegel-Matthies, K. (2013). Ethik, Konsumentenverantwortung und Verbraucherbildung
im Spannungsfeld. Haushalt in Bildung und Forschung (HiBiFo), 2(2),
61–70.
bibtex: '@article{Schlegel-Matthies_2013, title={Ethik, Konsumentenverantwortung
und Verbraucherbildung im Spannungsfeld}, volume={2}, number={2}, journal={Haushalt
in Bildung und Forschung (HiBiFo)}, author={Schlegel-Matthies, Kirsten}, year={2013},
pages={61–70} }'
chicago: 'Schlegel-Matthies, Kirsten. “Ethik, Konsumentenverantwortung und Verbraucherbildung
im Spannungsfeld.” Haushalt in Bildung und Forschung (HiBiFo) 2, no. 2
(2013): 61–70.'
ieee: K. Schlegel-Matthies, “Ethik, Konsumentenverantwortung und Verbraucherbildung
im Spannungsfeld,” Haushalt in Bildung und Forschung (HiBiFo), vol. 2,
no. 2, pp. 61–70, 2013.
mla: Schlegel-Matthies, Kirsten. “Ethik, Konsumentenverantwortung und Verbraucherbildung
im Spannungsfeld.” Haushalt in Bildung und Forschung (HiBiFo), vol. 2,
no. 2, 2013, pp. 61–70.
short: K. Schlegel-Matthies, Haushalt in Bildung und Forschung (HiBiFo) 2 (2013)
61–70.
date_created: 2021-11-17T10:43:57Z
date_updated: 2022-01-06T06:57:40Z
department:
- _id: '35'
- _id: '22'
- _id: '396'
intvolume: ' 2'
issue: '2'
language:
- iso: ger
page: 61 - 70
publication: Haushalt in Bildung und Forschung (HiBiFo)
publication_status: published
status: public
title: Ethik, Konsumentenverantwortung und Verbraucherbildung im Spannungsfeld
type: journal_article
user_id: '49428'
volume: 2
year: '2013'
...
---
_id: '27516'
author:
- first_name: Kirsten
full_name: Schlegel-Matthies, Kirsten
id: '459'
last_name: Schlegel-Matthies
citation:
ama: 'Schlegel-Matthies K. Fachliche Betreuung des Schwerpunktthemas: Ethik – Konsum
– Verbraucherbildung. . Haushalt in Bildung und Forschung (HiBiFo). 2013;2(2).'
apa: 'Schlegel-Matthies, K. (2013). Fachliche Betreuung des Schwerpunktthemas: Ethik
– Konsum – Verbraucherbildung. . Haushalt in Bildung und Forschung (HiBiFo),
2(2).'
bibtex: '@article{Schlegel-Matthies_2013, title={Fachliche Betreuung des Schwerpunktthemas:
Ethik – Konsum – Verbraucherbildung. }, volume={2}, number={2}, journal={Haushalt
in Bildung und Forschung (HiBiFo)}, author={Schlegel-Matthies, Kirsten}, year={2013}
}'
chicago: 'Schlegel-Matthies, Kirsten. “Fachliche Betreuung des Schwerpunktthemas:
Ethik – Konsum – Verbraucherbildung. .” Haushalt in Bildung und Forschung (HiBiFo)
2, no. 2 (2013).'
ieee: 'K. Schlegel-Matthies, “Fachliche Betreuung des Schwerpunktthemas: Ethik –
Konsum – Verbraucherbildung. ,” Haushalt in Bildung und Forschung (HiBiFo),
vol. 2, no. 2, 2013.'
mla: 'Schlegel-Matthies, Kirsten. “Fachliche Betreuung des Schwerpunktthemas: Ethik
– Konsum – Verbraucherbildung. .” Haushalt in Bildung und Forschung (HiBiFo),
vol. 2, no. 2, 2013.'
short: K. Schlegel-Matthies, Haushalt in Bildung und Forschung (HiBiFo) 2 (2013).
date_created: 2021-11-17T10:45:32Z
date_updated: 2022-01-06T06:57:40Z
department:
- _id: '35'
- _id: '22'
- _id: '396'
intvolume: ' 2'
issue: '2'
language:
- iso: ger
publication: Haushalt in Bildung und Forschung (HiBiFo)
publication_status: published
status: public
title: 'Fachliche Betreuung des Schwerpunktthemas: Ethik – Konsum – Verbraucherbildung. '
type: journal_article
user_id: '49428'
volume: 2
year: '2013'
...
---
_id: '27518'
author:
- first_name: Anke
full_name: Oepping, Anke
last_name: Oepping
- first_name: Kirsten
full_name: Schlegel-Matthies, Kirsten
id: '459'
last_name: Schlegel-Matthies
citation:
ama: Oepping A, Schlegel-Matthies K. Ernährungs- und Verbraucherbildung im Unterricht
. 4th ed.; 2013.
apa: Oepping, A., & Schlegel-Matthies, K. (2013). Ernährungs- und Verbraucherbildung
im Unterricht (4th ed.).
bibtex: '@book{Oepping_Schlegel-Matthies_2013, place={Bonn}, edition={4}, title={Ernährungs-
und Verbraucherbildung im Unterricht }, author={Oepping, Anke and Schlegel-Matthies,
Kirsten}, year={2013} }'
chicago: Oepping, Anke, and Kirsten Schlegel-Matthies. Ernährungs- und Verbraucherbildung
im Unterricht . 4th ed. Bonn, 2013.
ieee: A. Oepping and K. Schlegel-Matthies, Ernährungs- und Verbraucherbildung
im Unterricht , 4th ed. Bonn, 2013.
mla: Oepping, Anke, and Kirsten Schlegel-Matthies. Ernährungs- und Verbraucherbildung
im Unterricht . 4th ed., 2013.
short: A. Oepping, K. Schlegel-Matthies, Ernährungs- und Verbraucherbildung im Unterricht
, 4th ed., Bonn, 2013.
date_created: 2021-11-17T10:47:35Z
date_updated: 2022-01-06T06:57:40Z
department:
- _id: '35'
- _id: '22'
- _id: '396'
edition: '4'
language:
- iso: ger
place: Bonn
publication_status: published
status: public
title: 'Ernährungs- und Verbraucherbildung im Unterricht '
type: book
user_id: '49428'
year: '2013'
...
---
_id: '27524'
abstract:
- lang: eng
text: Because of widespread irregular lunch consumption by both children
and adults, information on the effects of lunch on short-term cognitive functioning
is relevant to public health. In September 2012, a MEDLINE search was conducted
for studies in which the effects of lunch on cognitive performance were examined.
Eleven experimental studies published from 1981 to 1996 were found and evaluated;
all involved adults. In three studies, the effects of lunch and lunch skipping
were compared; the remaining studies involved a determination of the effects of
lunch size and lunch composition. Results of studies in which lunch was compared
with no lunch indicate that lunch leads to potential impairment of some aspects
of cognitive functioning in the early afternoon. Lunch size may influence cognitive
functioning, with impairment more likely to occur after a large lunch than a small
lunch. Furthermore, in comparison with low-fat lunches, high-fat lunches seem
to result in slower but more accurate responses to some cognitive tasks. However,
these suggestions must be viewed with caution, as they are based on only a few
studies and are not thoroughly supported by high-quality evidence. In addition,
results obtained with adults are not applicable to children. Thus, the potential
effects of lunch need further examination in children and adults.
author:
- first_name: Katrin
full_name: Müller, Katrin
last_name: Müller
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: Anna Maria
full_name: Terschlüsen, Anna Maria
last_name: Terschlüsen
- first_name: Mathilde
full_name: Kersting, Mathilde
last_name: Kersting
citation:
ama: 'Müller K, Libuda L, Terschlüsen AM, Kersting M. A Review of the Effects of
Lunch: On Adults’ Short-term Cognitive Functioning. Canadian Journal of Dietetic
Practice and Research. Published online 2013:181-188. doi:10.3148/74.4.2013.181'
apa: 'Müller, K., Libuda, L., Terschlüsen, A. M., & Kersting, M. (2013). A Review
of the Effects of Lunch: On Adults’ Short-term Cognitive Functioning. Canadian
Journal of Dietetic Practice and Research, 181–188. https://doi.org/10.3148/74.4.2013.181'
bibtex: '@article{Müller_Libuda_Terschlüsen_Kersting_2013, title={A Review of the
Effects of Lunch: On Adults’ Short-term Cognitive Functioning}, DOI={10.3148/74.4.2013.181},
journal={Canadian Journal of Dietetic Practice and Research}, author={Müller,
Katrin and Libuda, Lars and Terschlüsen, Anna Maria and Kersting, Mathilde}, year={2013},
pages={181–188} }'
chicago: 'Müller, Katrin, Lars Libuda, Anna Maria Terschlüsen, and Mathilde Kersting.
“A Review of the Effects of Lunch: On Adults’ Short-Term Cognitive Functioning.”
Canadian Journal of Dietetic Practice and Research, 2013, 181–88. https://doi.org/10.3148/74.4.2013.181.'
ieee: 'K. Müller, L. Libuda, A. M. Terschlüsen, and M. Kersting, “A Review of the
Effects of Lunch: On Adults’ Short-term Cognitive Functioning,” Canadian Journal
of Dietetic Practice and Research, pp. 181–188, 2013, doi: 10.3148/74.4.2013.181.'
mla: 'Müller, Katrin, et al. “A Review of the Effects of Lunch: On Adults’ Short-Term
Cognitive Functioning.” Canadian Journal of Dietetic Practice and Research,
2013, pp. 181–88, doi:10.3148/74.4.2013.181.'
short: K. Müller, L. Libuda, A.M. Terschlüsen, M. Kersting, Canadian Journal of
Dietetic Practice and Research (2013) 181–188.
date_created: 2021-11-17T11:07:28Z
date_updated: 2022-01-06T06:57:40Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.3148/74.4.2013.181
language:
- iso: eng
page: 181-188
publication: Canadian Journal of Dietetic Practice and Research
publication_identifier:
issn:
- 1486-3847
- 2292-9592
publication_status: published
status: public
title: 'A Review of the Effects of Lunch: On Adults’ Short-term Cognitive Functioning'
type: journal_article
user_id: '49428'
year: '2013'
...
---
_id: '27581'
author:
- first_name: C.
full_name: Mesch, C.
last_name: Mesch
- first_name: 'M. '
full_name: 'Stimming, M. '
last_name: Stimming
- first_name: A.
full_name: Wagner, A.
last_name: Wagner
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: M.
full_name: Kersting, M.
last_name: Kersting
citation:
ama: Mesch C, Stimming M, Wagner A, Libuda L, Kersting M. Rekrutierung von Müttern
mit Säuglingen in einer Interventionsstudie – erste Erkenntnisse aus der PINGU-Studie.
. Ernährungsumschau International. 2013;7:110-115.
apa: Mesch, C., Stimming, M., Wagner, A., Libuda, L., & Kersting, M. (2013).
Rekrutierung von Müttern mit Säuglingen in einer Interventionsstudie – erste Erkenntnisse
aus der PINGU-Studie. . Ernährungsumschau International, 7, 110–115.
bibtex: '@article{Mesch_Stimming_Wagner_Libuda_Kersting_2013, title={Rekrutierung
von Müttern mit Säuglingen in einer Interventionsstudie – erste Erkenntnisse aus
der PINGU-Studie. }, volume={7}, journal={Ernährungsumschau International}, author={Mesch,
C. and Stimming, M. and Wagner, A. and Libuda, Lars and Kersting, M.}, year={2013},
pages={110–115} }'
chicago: 'Mesch, C., M. Stimming, A. Wagner, Lars Libuda, and M. Kersting. “Rekrutierung
von Müttern mit Säuglingen in einer Interventionsstudie – erste Erkenntnisse aus
der PINGU-Studie. .” Ernährungsumschau International 7 (2013): 110–15.'
ieee: C. Mesch, M. Stimming, A. Wagner, L. Libuda, and M. Kersting, “Rekrutierung
von Müttern mit Säuglingen in einer Interventionsstudie – erste Erkenntnisse aus
der PINGU-Studie. ,” Ernährungsumschau International, vol. 7, pp. 110–115,
2013.
mla: Mesch, C., et al. “Rekrutierung von Müttern mit Säuglingen in einer Interventionsstudie
– erste Erkenntnisse aus der PINGU-Studie. .” Ernährungsumschau International,
vol. 7, 2013, pp. 110–15.
short: C. Mesch, M. Stimming, A. Wagner, L. Libuda, M. Kersting, Ernährungsumschau
International 7 (2013) 110–115.
date_created: 2021-11-19T09:36:55Z
date_updated: 2022-01-06T06:57:42Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
intvolume: ' 7'
language:
- iso: ger
page: 110-115
publication: Ernährungsumschau International
publication_status: published
status: public
title: 'Rekrutierung von Müttern mit Säuglingen in einer Interventionsstudie – erste
Erkenntnisse aus der PINGU-Studie. '
type: journal_article
user_id: '49428'
volume: 7
year: '2013'
...
---
_id: '27732'
author:
- first_name: K.E.
full_name: Assmann, K.E.
last_name: Assmann
- first_name: G.
full_name: Joslowski, G.
last_name: Joslowski
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
- first_name: G.
full_name: Cheng, G.
last_name: Cheng
- first_name: T.
full_name: Remer, T.
last_name: Remer
- first_name: A.
full_name: Kroke, A.
last_name: Kroke
- first_name: A.L.B.
full_name: Günther, A.L.B.
last_name: Günther
citation:
ama: Assmann KE, Joslowski G, Buyken A, et al. Prospective association of protein
intake during puberty with body composition in young adulthood. Obesity.
Published online 2013:E782-E789. doi:10.1002/oby.20516
apa: Assmann, K. E., Joslowski, G., Buyken, A., Cheng, G., Remer, T., Kroke, A.,
& Günther, A. L. B. (2013). Prospective association of protein intake during
puberty with body composition in young adulthood. Obesity, E782–E789. https://doi.org/10.1002/oby.20516
bibtex: '@article{Assmann_Joslowski_Buyken_Cheng_Remer_Kroke_Günther_2013, title={Prospective
association of protein intake during puberty with body composition in young adulthood},
DOI={10.1002/oby.20516}, journal={Obesity},
author={Assmann, K.E. and Joslowski, G. and Buyken, Anette and Cheng, G. and Remer,
T. and Kroke, A. and Günther, A.L.B.}, year={2013}, pages={E782–E789} }'
chicago: Assmann, K.E., G. Joslowski, Anette Buyken, G. Cheng, T. Remer, A. Kroke,
and A.L.B. Günther. “Prospective Association of Protein Intake during Puberty
with Body Composition in Young Adulthood.” Obesity, 2013, E782–89. https://doi.org/10.1002/oby.20516.
ieee: 'K. E. Assmann et al., “Prospective association of protein intake during
puberty with body composition in young adulthood,” Obesity, pp. E782–E789,
2013, doi: 10.1002/oby.20516.'
mla: Assmann, K. E., et al. “Prospective Association of Protein Intake during Puberty
with Body Composition in Young Adulthood.” Obesity, 2013, pp. E782–89,
doi:10.1002/oby.20516.
short: K.E. Assmann, G. Joslowski, A. Buyken, G. Cheng, T. Remer, A. Kroke, A.L.B.
Günther, Obesity (2013) E782–E789.
date_created: 2021-11-23T16:01:14Z
date_updated: 2022-01-06T06:57:44Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.1002/oby.20516
language:
- iso: eng
page: E782-E789
publication: Obesity
publication_identifier:
issn:
- 1930-7381
publication_status: published
status: public
title: Prospective association of protein intake during puberty with body composition
in young adulthood
type: journal_article
user_id: '61597'
year: '2013'
...
---
_id: '27733'
article_number: e79436
author:
- first_name: Anke L. B.
full_name: Günther, Anke L. B.
last_name: Günther
- first_name: Helena
full_name: Walz, Helena
last_name: Walz
- first_name: Anja
full_name: Kroke, Anja
last_name: Kroke
- first_name: Stefan A.
full_name: Wudy, Stefan A.
last_name: Wudy
- first_name: Christina
full_name: Riedel, Christina
last_name: Riedel
- first_name: Rüdiger
full_name: von Kries, Rüdiger
last_name: von Kries
- first_name: Gesa
full_name: Joslowski, Gesa
last_name: Joslowski
- first_name: Thomas
full_name: Remer, Thomas
last_name: Remer
- first_name: Guo
full_name: Cheng, Guo
last_name: Cheng
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
citation:
ama: Günther ALB, Walz H, Kroke A, et al. Breastfeeding and Its Prospective Association
with Components of the GH-IGF-Axis, Insulin Resistance and Body Adiposity Measures
in Young Adulthood – Insights from Linear and Quantile Regression Analysis. PLoS
ONE. Published online 2013. doi:10.1371/journal.pone.0079436
apa: Günther, A. L. B., Walz, H., Kroke, A., Wudy, S. A., Riedel, C., von Kries,
R., Joslowski, G., Remer, T., Cheng, G., & Buyken, A. (2013). Breastfeeding
and Its Prospective Association with Components of the GH-IGF-Axis, Insulin Resistance
and Body Adiposity Measures in Young Adulthood – Insights from Linear and Quantile
Regression Analysis. PLoS ONE, Article e79436. https://doi.org/10.1371/journal.pone.0079436
bibtex: '@article{Günther_Walz_Kroke_Wudy_Riedel_von Kries_Joslowski_Remer_Cheng_Buyken_2013,
title={Breastfeeding and Its Prospective Association with Components of the GH-IGF-Axis,
Insulin Resistance and Body Adiposity Measures in Young Adulthood – Insights from
Linear and Quantile Regression Analysis}, DOI={10.1371/journal.pone.0079436},
number={e79436}, journal={PLoS ONE}, author={Günther, Anke L. B. and Walz, Helena
and Kroke, Anja and Wudy, Stefan A. and Riedel, Christina and von Kries, Rüdiger
and Joslowski, Gesa and Remer, Thomas and Cheng, Guo and Buyken, Anette}, year={2013}
}'
chicago: Günther, Anke L. B., Helena Walz, Anja Kroke, Stefan A. Wudy, Christina
Riedel, Rüdiger von Kries, Gesa Joslowski, Thomas Remer, Guo Cheng, and Anette
Buyken. “Breastfeeding and Its Prospective Association with Components of the
GH-IGF-Axis, Insulin Resistance and Body Adiposity Measures in Young Adulthood
– Insights from Linear and Quantile Regression Analysis.” PLoS ONE, 2013.
https://doi.org/10.1371/journal.pone.0079436.
ieee: 'A. L. B. Günther et al., “Breastfeeding and Its Prospective Association
with Components of the GH-IGF-Axis, Insulin Resistance and Body Adiposity Measures
in Young Adulthood – Insights from Linear and Quantile Regression Analysis,” PLoS
ONE, Art. no. e79436, 2013, doi: 10.1371/journal.pone.0079436.'
mla: Günther, Anke L. B., et al. “Breastfeeding and Its Prospective Association
with Components of the GH-IGF-Axis, Insulin Resistance and Body Adiposity Measures
in Young Adulthood – Insights from Linear and Quantile Regression Analysis.” PLoS
ONE, e79436, 2013, doi:10.1371/journal.pone.0079436.
short: A.L.B. Günther, H. Walz, A. Kroke, S.A. Wudy, C. Riedel, R. von Kries, G.
Joslowski, T. Remer, G. Cheng, A. Buyken, PLoS ONE (2013).
date_created: 2021-11-23T16:02:57Z
date_updated: 2022-01-06T06:57:44Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.1371/journal.pone.0079436
language:
- iso: eng
publication: PLoS ONE
publication_identifier:
issn:
- 1932-6203
publication_status: published
status: public
title: Breastfeeding and Its Prospective Association with Components of the GH-IGF-Axis,
Insulin Resistance and Body Adiposity Measures in Young Adulthood – Insights from
Linear and Quantile Regression Analysis
type: journal_article
user_id: '61597'
year: '2013'
...
---
_id: '36002'
author:
- first_name: Kirsten
full_name: Schlegel-Matthies, Kirsten
id: '459'
last_name: Schlegel-Matthies
- first_name: Barbara
full_name: Methfessel, Barbara
last_name: Methfessel
citation:
ama: Schlegel-Matthies K, Methfessel B. Für eine veränderte Fachpraxis - Zur Kultur
und Technik der Nahrungszubereitung und Mahlzeitengestaltung. Haushalt in Bidlung
und Forschung. 2013;2(4):49-60.
apa: Schlegel-Matthies, K., & Methfessel, B. (2013). Für eine veränderte Fachpraxis
- Zur Kultur und Technik der Nahrungszubereitung und Mahlzeitengestaltung. Haushalt
in Bidlung und Forschung, 2(4), 49–60.
bibtex: '@article{Schlegel-Matthies_Methfessel_2013, title={Für eine veränderte
Fachpraxis - Zur Kultur und Technik der Nahrungszubereitung und Mahlzeitengestaltung},
volume={2}, number={4}, journal={Haushalt in Bidlung und Forschung}, publisher={Barbara
Budrich}, author={Schlegel-Matthies, Kirsten and Methfessel, Barbara}, year={2013},
pages={49–60} }'
chicago: 'Schlegel-Matthies, Kirsten, and Barbara Methfessel. “Für eine veränderte
Fachpraxis - Zur Kultur und Technik der Nahrungszubereitung und Mahlzeitengestaltung.”
Haushalt in Bidlung und Forschung 2, no. 4 (2013): 49–60.'
ieee: K. Schlegel-Matthies and B. Methfessel, “Für eine veränderte Fachpraxis -
Zur Kultur und Technik der Nahrungszubereitung und Mahlzeitengestaltung,” Haushalt
in Bidlung und Forschung, vol. 2, no. 4, pp. 49–60, 2013.
mla: Schlegel-Matthies, Kirsten, and Barbara Methfessel. “Für eine veränderte Fachpraxis
- Zur Kultur und Technik der Nahrungszubereitung und Mahlzeitengestaltung.” Haushalt
in Bidlung und Forschung, vol. 2, no. 4, Barbara Budrich, 2013, pp. 49–60.
short: K. Schlegel-Matthies, B. Methfessel, Haushalt in Bidlung und Forschung 2
(2013) 49–60.
date_created: 2023-01-11T10:53:33Z
date_updated: 2023-01-11T10:53:42Z
department:
- _id: '35'
- _id: '17'
- _id: '22'
- _id: '396'
intvolume: ' 2'
issue: '4'
language:
- iso: ger
page: 49-60
publication: Haushalt in Bidlung und Forschung
publication_identifier:
issn:
- 2193-8806
publication_status: published
publisher: Barbara Budrich
status: public
title: Für eine veränderte Fachpraxis - Zur Kultur und Technik der Nahrungszubereitung
und Mahlzeitengestaltung
type: journal_article
user_id: '459'
volume: 2
year: '2013'
...
---
_id: '54933'
abstract:
- lang: eng
text: In some patients with atypical cystic fibrosis (CF), only one allele of the
CF transmembrane conductance regulator (CFTR) gene is affected. Mutations of the
epithelial sodium channel (ENaC) may contribute to the pathophysiology of the
disease in these patients. To functionally characterize a mutation in the $\beta$-subunit
of ENaC ($\beta$V348M) recently identified in a patient with severe CF-like symptoms
(Mutesa et al. 2009), we expressed wild-type (wt) $\alpha$$\beta$$\gamma$ENaC
or mutant $\alpha$$\beta$V348M$\gamma$ENaC in Xenopus laevis oocytes. The $\beta$V348M
mutation stimulated amiloride-sensitive whole-cell current ($\Delta$I(ami)) by
$\sim$40% but had no effect on surface expression or single-channel conductance
of ENaC. Instead the mutation increased channel open probability (P(o)). Proteolytic
activation of mutant ENaC by chymotrypsin was reduced compared with that of wt
ENaC ($\sim$3.0-fold vs. $\sim$4.2-fold), which is consistent with the increased
baseline P(o) of mutant ENaC. Similarly, the ENaC activator S3969 stimulated mutant
ENaC currents to a lesser degree (by $\sim$2.6-fold) than wt ENaC currents (by
$\sim$3.5-fold). The gain-of-function effect of the $\beta$V348M mutation was
confirmed by whole-cell current measurements in HEK293 cells transiently transfected
with wt or mutant ENaC. Computational channel modeling in combination with functional
expression of different $\beta$V348 mutants in oocytes suggests that the $\beta$V348M
mutation increases channel P(o) by destabilizing the closed channel state. Our
findings indicate that the gain-of-function effect of the $\beta$V348M mutation
may contribute to CF pathophysiology by inappropriately increasing sodium and
fluid absorption in the respiratory tract.
author:
- first_name: Robert
full_name: Rauh, Robert
last_name: Rauh
- first_name: Daniel
full_name: Soell, Daniel
last_name: Soell
- first_name: Silke
full_name: Haerteis, Silke
last_name: Haerteis
- first_name: Alexei
full_name: Diakov, Alexei
last_name: Diakov
- first_name: Viatcheslav
full_name: Nesterov, Viatcheslav
last_name: Nesterov
- first_name: Bettina
full_name: Krueger, Bettina
id: '49428'
last_name: Krueger
orcid: 0000-0001-5351-1785
- first_name: Heinrich
full_name: Sticht, Heinrich
last_name: Sticht
- first_name: Christoph
full_name: Korbmacher, Christoph
last_name: Korbmacher
citation:
ama: Rauh R, Soell D, Haerteis S, et al. A mutation in the $\beta$-subunit of ENaC
identified in a patient with cystic fibrosis-like symptoms has a gain-of-function
effect. American Journal of Physiology-Lung Cellular and Molecular Physiology.
2013;304(1):L43–L55. doi:10.1152/ajplung.00093.2012
apa: Rauh, R., Soell, D., Haerteis, S., Diakov, A., Nesterov, V., Krueger, B., Sticht,
H., & Korbmacher, C. (2013). A mutation in the $\beta$-subunit of ENaC identified
in a patient with cystic fibrosis-like symptoms has a gain-of-function effect.
American Journal of Physiology-Lung Cellular and Molecular Physiology,
304(1), L43–L55. https://doi.org/10.1152/ajplung.00093.2012
bibtex: '@article{Rauh_Soell_Haerteis_Diakov_Nesterov_Krueger_Sticht_Korbmacher_2013,
title={A mutation in the $\beta$-subunit of ENaC identified in a patient with
cystic fibrosis-like symptoms has a gain-of-function effect}, volume={304}, DOI={10.1152/ajplung.00093.2012},
number={1}, journal={American Journal of Physiology-Lung Cellular and Molecular
Physiology}, publisher={American Physiological Society}, author={Rauh, Robert
and Soell, Daniel and Haerteis, Silke and Diakov, Alexei and Nesterov, Viatcheslav
and Krueger, Bettina and Sticht, Heinrich and Korbmacher, Christoph}, year={2013},
pages={L43–L55} }'
chicago: 'Rauh, Robert, Daniel Soell, Silke Haerteis, Alexei Diakov, Viatcheslav
Nesterov, Bettina Krueger, Heinrich Sticht, and Christoph Korbmacher. “A Mutation
in the $\beta$-Subunit of ENaC Identified in a Patient with Cystic Fibrosis-like
Symptoms Has a Gain-of-Function Effect.” American Journal of Physiology-Lung
Cellular and Molecular Physiology 304, no. 1 (2013): L43–L55. https://doi.org/10.1152/ajplung.00093.2012.'
ieee: 'R. Rauh et al., “A mutation in the $\beta$-subunit of ENaC identified
in a patient with cystic fibrosis-like symptoms has a gain-of-function effect,”
American Journal of Physiology-Lung Cellular and Molecular Physiology,
vol. 304, no. 1, pp. L43–L55, 2013, doi: 10.1152/ajplung.00093.2012.'
mla: Rauh, Robert, et al. “A Mutation in the $\beta$-Subunit of ENaC Identified
in a Patient with Cystic Fibrosis-like Symptoms Has a Gain-of-Function Effect.”
American Journal of Physiology-Lung Cellular and Molecular Physiology,
vol. 304, no. 1, American Physiological Society, 2013, pp. L43–L55, doi:10.1152/ajplung.00093.2012.
short: R. Rauh, D. Soell, S. Haerteis, A. Diakov, V. Nesterov, B. Krueger, H. Sticht,
C. Korbmacher, American Journal of Physiology-Lung Cellular and Molecular Physiology
304 (2013) L43–L55.
date_created: 2024-06-30T13:47:44Z
date_updated: 2024-06-30T13:47:56Z
department:
- _id: '35'
- _id: '22'
doi: 10.1152/ajplung.00093.2012
intvolume: ' 304'
issue: '1'
language:
- iso: eng
page: L43–L55
publication: American Journal of Physiology-Lung Cellular and Molecular Physiology
publisher: American Physiological Society
status: public
title: A mutation in the $\beta$-subunit of ENaC identified in a patient with cystic
fibrosis-like symptoms has a gain-of-function effect
type: journal_article
user_id: '49428'
volume: 304
year: '2013'
...