[{"department":[{"_id":"302"}],"type":"journal_article","date_created":"2021-07-08T11:46:53Z","abstract":[{"text":"<jats:title>Abstract</jats:title>\r\n               <jats:p>Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers.</jats:p>","lang":"eng"}],"citation":{"ieee":"H. Ijäs <i>et al.</i>, “Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release,” <i>Nucleic Acids Research</i>, vol. 49, pp. 3048–3062, 2021.","apa":"Ijäs, H., Shen, B., Heuer-Jungemann, A., Keller, A., Kostiainen, M. A., Liedl, T., … Linko, V. (2021). Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. <i>Nucleic Acids Research</i>, <i>49</i>, 3048–3062. <a href=\"https://doi.org/10.1093/nar/gkab097\">https://doi.org/10.1093/nar/gkab097</a>","chicago":"Ijäs, Heini, Boxuan Shen, Amelie Heuer-Jungemann, Adrian Keller, Mauri A Kostiainen, Tim Liedl, Janne A Ihalainen, and Veikko Linko. “Unraveling the Interaction between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” <i>Nucleic Acids Research</i> 49 (2021): 3048–62. <a href=\"https://doi.org/10.1093/nar/gkab097\">https://doi.org/10.1093/nar/gkab097</a>.","short":"H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M.A. Kostiainen, T. Liedl, J.A. Ihalainen, V. Linko, Nucleic Acids Research 49 (2021) 3048–3062.","mla":"Ijäs, Heini, et al. “Unraveling the Interaction between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” <i>Nucleic Acids Research</i>, vol. 49, 2021, pp. 3048–62, doi:<a href=\"https://doi.org/10.1093/nar/gkab097\">10.1093/nar/gkab097</a>.","bibtex":"@article{Ijäs_Shen_Heuer-Jungemann_Keller_Kostiainen_Liedl_Ihalainen_Linko_2021, title={Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release}, volume={49}, DOI={<a href=\"https://doi.org/10.1093/nar/gkab097\">10.1093/nar/gkab097</a>}, journal={Nucleic Acids Research}, author={Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann, Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen, Janne A and Linko, Veikko}, year={2021}, pages={3048–3062} }","ama":"Ijäs H, Shen B, Heuer-Jungemann A, et al. Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. <i>Nucleic Acids Research</i>. 2021;49:3048-3062. doi:<a href=\"https://doi.org/10.1093/nar/gkab097\">10.1093/nar/gkab097</a>"},"publication":"Nucleic Acids Research","volume":49,"user_id":"48864","doi":"10.1093/nar/gkab097","_id":"22637","language":[{"iso":"eng"}],"page":"3048-3062","intvolume":"        49","publication_status":"published","date_updated":"2022-01-06T06:55:37Z","publication_identifier":{"issn":["0305-1048","1362-4962"]},"author":[{"first_name":"Heini","last_name":"Ijäs","full_name":"Ijäs, Heini"},{"full_name":"Shen, Boxuan","last_name":"Shen","first_name":"Boxuan"},{"last_name":"Heuer-Jungemann","first_name":"Amelie","full_name":"Heuer-Jungemann, Amelie"},{"full_name":"Keller, Adrian","last_name":"Keller","first_name":"Adrian","orcid":"0000-0001-7139-3110","id":"48864"},{"last_name":"Kostiainen","first_name":"Mauri A","full_name":"Kostiainen, Mauri A"},{"full_name":"Liedl, Tim","first_name":"Tim","last_name":"Liedl"},{"first_name":"Janne A","last_name":"Ihalainen","full_name":"Ihalainen, Janne A"},{"first_name":"Veikko","last_name":"Linko","full_name":"Linko, Veikko"}],"title":"Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release","status":"public","year":"2021"},{"status":"public","_id":"22638","page":"8564-8571","volume":27,"user_id":"48864","citation":{"bibtex":"@article{Xin_Shen_Kostiainen_Grundmeier_Castro_Linko_Keller_2021, title={Scaling Up DNA Origami Lattice Assembly.}, volume={27}, DOI={<a href=\"https://doi.org/10.1002/chem.202100784\">10.1002/chem.202100784</a>}, number={33}, journal={Chemistry – A European Journal}, author={Xin, Y and Shen, B and Kostiainen, MA and Grundmeier, Guido and Castro, M and Linko, V and Keller, Adrian}, year={2021}, pages={8564–8571} }","ama":"Xin Y, Shen B, Kostiainen M, et al. Scaling Up DNA Origami Lattice Assembly. <i>Chemistry – A European Journal</i>. 2021;27(33):8564-8571. doi:<a href=\"https://doi.org/10.1002/chem.202100784\">10.1002/chem.202100784</a>","mla":"Xin, Y., et al. “Scaling Up DNA Origami Lattice Assembly.” <i>Chemistry – A European Journal</i>, vol. 27, no. 33, 2021, pp. 8564–71, doi:<a href=\"https://doi.org/10.1002/chem.202100784\">10.1002/chem.202100784</a>.","short":"Y. Xin, B. Shen, M. Kostiainen, G. Grundmeier, M. Castro, V. Linko, A. Keller, Chemistry – A European Journal 27 (2021) 8564–8571.","chicago":"Xin, Y, B Shen, MA Kostiainen, Guido Grundmeier, M Castro, V Linko, and Adrian Keller. “Scaling Up DNA Origami Lattice Assembly.” <i>Chemistry – A European Journal</i> 27, no. 33 (2021): 8564–71. <a href=\"https://doi.org/10.1002/chem.202100784\">https://doi.org/10.1002/chem.202100784</a>.","ieee":"Y. Xin <i>et al.</i>, “Scaling Up DNA Origami Lattice Assembly.,” <i>Chemistry – A European Journal</i>, vol. 27, no. 33, pp. 8564–8571, 2021.","apa":"Xin, Y., Shen, B., Kostiainen, M., Grundmeier, G., Castro, M., Linko, V., &#38; Keller, A. (2021). Scaling Up DNA Origami Lattice Assembly. <i>Chemistry – A European Journal</i>, <i>27</i>(33), 8564–8571. <a href=\"https://doi.org/10.1002/chem.202100784\">https://doi.org/10.1002/chem.202100784</a>"},"external_id":{"pmid":["33780583"]},"author":[{"full_name":"Xin, Y","last_name":"Xin","first_name":"Y"},{"full_name":"Shen, B","last_name":"Shen","first_name":"B"},{"last_name":"Kostiainen","first_name":"MA","full_name":"Kostiainen, MA"},{"last_name":"Grundmeier","first_name":"Guido","full_name":"Grundmeier, Guido","id":"194"},{"first_name":"M","last_name":"Castro","full_name":"Castro, M"},{"full_name":"Linko, V","last_name":"Linko","first_name":"V"},{"first_name":"Adrian","last_name":"Keller","orcid":"0000-0001-7139-3110","full_name":"Keller, Adrian","id":"48864"}],"publication_identifier":{"issn":["0947-6539","1521-3765"]},"title":"Scaling Up DNA Origami Lattice Assembly.","year":"2021","intvolume":"        27","date_updated":"2022-01-06T06:55:37Z","language":[{"iso":"eng"}],"pmid":"1","doi":"10.1002/chem.202100784","publication":"Chemistry – A European Journal","issue":"33","date_created":"2021-07-08T11:48:08Z","department":[{"_id":"302"}],"type":"journal_article"},{"publication":"Nanomaterials","issue":"2","type":"journal_article","department":[{"_id":"302"}],"date_created":"2021-07-08T11:50:44Z","date_updated":"2022-01-06T06:55:37Z","intvolume":"        11","title":"Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness.","year":"2021","author":[{"first_name":"Y","last_name":"Yang","full_name":"Yang, Y"},{"first_name":"S","last_name":"Knust","full_name":"Knust, S"},{"first_name":"S","last_name":"Schwiderek","full_name":"Schwiderek, S"},{"first_name":"Q","last_name":"Qin","full_name":"Qin, Q"},{"last_name":"Yun","first_name":"Q","full_name":"Yun, Q"},{"id":"194","first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido"},{"first_name":"Adrian","last_name":"Keller","orcid":"0000-0001-7139-3110","full_name":"Keller, Adrian","id":"48864"}],"publication_identifier":{"issn":["2079-4991"]},"doi":"10.3390/nano11020357","pmid":"1","language":[{"iso":"eng"}],"citation":{"ieee":"Y. Yang <i>et al.</i>, “Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness.,” <i>Nanomaterials</i>, vol. 11, no. 2, p. 357, 2021.","apa":"Yang, Y., Knust, S., Schwiderek, S., Qin, Q., Yun, Q., Grundmeier, G., &#38; Keller, A. (2021). Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness. <i>Nanomaterials</i>, <i>11</i>(2), 357. <a href=\"https://doi.org/10.3390/nano11020357\">https://doi.org/10.3390/nano11020357</a>","short":"Y. Yang, S. Knust, S. Schwiderek, Q. Qin, Q. Yun, G. Grundmeier, A. Keller, Nanomaterials 11 (2021) 357.","chicago":"Yang, Y, S Knust, S Schwiderek, Q Qin, Q Yun, Guido Grundmeier, and Adrian Keller. “Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness.” <i>Nanomaterials</i> 11, no. 2 (2021): 357. <a href=\"https://doi.org/10.3390/nano11020357\">https://doi.org/10.3390/nano11020357</a>.","mla":"Yang, Y., et al. “Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness.” <i>Nanomaterials</i>, vol. 11, no. 2, 2021, p. 357, doi:<a href=\"https://doi.org/10.3390/nano11020357\">10.3390/nano11020357</a>.","bibtex":"@article{Yang_Knust_Schwiderek_Qin_Yun_Grundmeier_Keller_2021, title={Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness.}, volume={11}, DOI={<a href=\"https://doi.org/10.3390/nano11020357\">10.3390/nano11020357</a>}, number={2}, journal={Nanomaterials}, author={Yang, Y and Knust, S and Schwiderek, S and Qin, Q and Yun, Q and Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={357} }","ama":"Yang Y, Knust S, Schwiderek S, et al. Protein Adsorption at Nanorough Titanium Oxide Surfaces: The Importance of Surface Statistical Parameters beyond Surface Roughness. <i>Nanomaterials</i>. 2021;11(2):357. doi:<a href=\"https://doi.org/10.3390/nano11020357\">10.3390/nano11020357</a>"},"external_id":{"pmid":["33535535"]},"status":"public","user_id":"48864","volume":11,"page":" 357 ","_id":"22639"},{"publication":"ACS Applied Nano Materials","citation":{"ieee":"P. Piskunen, B. Shen, A. Keller, J. J. Toppari, M. A. Kostiainen, and V. Linko, “Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials,” <i>ACS Applied Nano Materials</i>, vol. 4, pp. 529–538, 2021.","apa":"Piskunen, P., Shen, B., Keller, A., Toppari, J. J., Kostiainen, M. A., &#38; Linko, V. (2021). Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials. <i>ACS Applied Nano Materials</i>, <i>4</i>, 529–538. <a href=\"https://doi.org/10.1021/acsanm.0c02849\">https://doi.org/10.1021/acsanm.0c02849</a>","chicago":"Piskunen, Petteri, Boxuan Shen, Adrian Keller, J. Jussi Toppari, Mauri A. Kostiainen, and Veikko Linko. “Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials.” <i>ACS Applied Nano Materials</i> 4 (2021): 529–38. <a href=\"https://doi.org/10.1021/acsanm.0c02849\">https://doi.org/10.1021/acsanm.0c02849</a>.","short":"P. Piskunen, B. Shen, A. Keller, J.J. Toppari, M.A. Kostiainen, V. Linko, ACS Applied Nano Materials 4 (2021) 529–538.","mla":"Piskunen, Petteri, et al. “Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials.” <i>ACS Applied Nano Materials</i>, vol. 4, 2021, pp. 529–38, doi:<a href=\"https://doi.org/10.1021/acsanm.0c02849\">10.1021/acsanm.0c02849</a>.","bibtex":"@article{Piskunen_Shen_Keller_Toppari_Kostiainen_Linko_2021, title={Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials}, volume={4}, DOI={<a href=\"https://doi.org/10.1021/acsanm.0c02849\">10.1021/acsanm.0c02849</a>}, journal={ACS Applied Nano Materials}, author={Piskunen, Petteri and Shen, Boxuan and Keller, Adrian and Toppari, J. Jussi and Kostiainen, Mauri A. and Linko, Veikko}, year={2021}, pages={529–538} }","ama":"Piskunen P, Shen B, Keller A, Toppari JJ, Kostiainen MA, Linko V. Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials. <i>ACS Applied Nano Materials</i>. 2021;4:529-538. doi:<a href=\"https://doi.org/10.1021/acsanm.0c02849\">10.1021/acsanm.0c02849</a>"},"type":"journal_article","department":[{"_id":"302"}],"date_created":"2021-07-08T11:51:39Z","publication_status":"published","date_updated":"2022-01-06T06:55:37Z","intvolume":"         4","title":"Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials","status":"public","year":"2021","author":[{"full_name":"Piskunen, Petteri","first_name":"Petteri","last_name":"Piskunen"},{"full_name":"Shen, Boxuan","last_name":"Shen","first_name":"Boxuan"},{"full_name":"Keller, Adrian","first_name":"Adrian","orcid":"0000-0001-7139-3110","last_name":"Keller","id":"48864"},{"full_name":"Toppari, J. Jussi","first_name":"J. Jussi","last_name":"Toppari"},{"last_name":"Kostiainen","first_name":"Mauri A.","full_name":"Kostiainen, Mauri A."},{"last_name":"Linko","first_name":"Veikko","full_name":"Linko, Veikko"}],"publication_identifier":{"issn":["2574-0970","2574-0970"]},"user_id":"48864","doi":"10.1021/acsanm.0c02849","volume":4,"page":"529-538","_id":"22640","language":[{"iso":"eng"}]},{"publication":"Advanced NanoBiomed Research","citation":{"chicago":"Smith, DM, and Adrian Keller. “DNA Nanostructures in the Fight Against Infectious Diseases.” <i>Advanced NanoBiomed Research</i> 1 (2021): 2000049. <a href=\"https://doi.org/10.1002/anbr.202000049\">https://doi.org/10.1002/anbr.202000049</a>.","short":"D. Smith, A. Keller, Advanced NanoBiomed Research 1 (2021) 2000049.","ieee":"D. Smith and A. Keller, “DNA Nanostructures in the Fight Against Infectious Diseases.,” <i>Advanced NanoBiomed Research</i>, vol. 1, p. 2000049, 2021.","apa":"Smith, D., &#38; Keller, A. (2021). DNA Nanostructures in the Fight Against Infectious Diseases. <i>Advanced NanoBiomed Research</i>, <i>1</i>, 2000049. <a href=\"https://doi.org/10.1002/anbr.202000049\">https://doi.org/10.1002/anbr.202000049</a>","bibtex":"@article{Smith_Keller_2021, title={DNA Nanostructures in the Fight Against Infectious Diseases.}, volume={1}, DOI={<a href=\"https://doi.org/10.1002/anbr.202000049\">10.1002/anbr.202000049</a>}, journal={Advanced NanoBiomed Research}, author={Smith, DM and Keller, Adrian}, year={2021}, pages={2000049} }","ama":"Smith D, Keller A. DNA Nanostructures in the Fight Against Infectious Diseases. <i>Advanced NanoBiomed Research</i>. 2021;1:2000049. doi:<a href=\"https://doi.org/10.1002/anbr.202000049\">10.1002/anbr.202000049</a>","mla":"Smith, DM, and Adrian Keller. “DNA Nanostructures in the Fight Against Infectious Diseases.” <i>Advanced NanoBiomed Research</i>, vol. 1, 2021, p. 2000049, doi:<a href=\"https://doi.org/10.1002/anbr.202000049\">10.1002/anbr.202000049</a>."},"external_id":{"pmid":["33615315"]},"date_created":"2021-07-08T11:53:25Z","type":"journal_article","department":[{"_id":"302"}],"title":"DNA Nanostructures in the Fight Against Infectious Diseases.","year":"2021","status":"public","publication_identifier":{"issn":["2699-9307"]},"author":[{"full_name":"Smith, DM","last_name":"Smith","first_name":"DM"},{"last_name":"Keller","first_name":"Adrian","orcid":"0000-0001-7139-3110","full_name":"Keller, Adrian","id":"48864"}],"date_updated":"2022-01-06T06:55:37Z","intvolume":"         1","page":"2000049","language":[{"iso":"eng"}],"_id":"22641","user_id":"48864","doi":"10.1002/anbr.202000049","pmid":"1","volume":1},{"language":[{"iso":"eng"}],"doi":"10.1002/anbr.202170023","pmid":"1","title":"Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.","year":"2021","author":[{"last_name":"Xin","first_name":"Y","full_name":"Xin, Y"},{"id":"194","last_name":"Grundmeier","first_name":"Guido","full_name":"Grundmeier, Guido"},{"orcid":"0000-0001-7139-3110","last_name":"Keller","first_name":"Adrian","full_name":"Keller, Adrian","id":"48864"}],"publication_identifier":{"issn":["2699-9307"]},"date_updated":"2022-01-06T06:55:37Z","intvolume":"         1","date_created":"2021-07-08T11:54:36Z","type":"journal_article","department":[{"_id":"302"}],"publication":"Advanced NanoBiomed Research","issue":"2","page":"2170023","_id":"22642","user_id":"48864","volume":1,"status":"public","external_id":{"pmid":["33786537"]},"citation":{"mla":"Xin, Y., et al. “Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.” <i>Advanced NanoBiomed Research</i>, vol. 1, no. 2, 2021, p. 2170023, doi:<a href=\"https://doi.org/10.1002/anbr.202170023\">10.1002/anbr.202170023</a>.","bibtex":"@article{Xin_Grundmeier_Keller_2021, title={Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.}, volume={1}, DOI={<a href=\"https://doi.org/10.1002/anbr.202170023\">10.1002/anbr.202170023</a>}, number={2}, journal={Advanced NanoBiomed Research}, author={Xin, Y and Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={2170023} }","ama":"Xin Y, Grundmeier G, Keller A. Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy. <i>Advanced NanoBiomed Research</i>. 2021;1(2):2170023. doi:<a href=\"https://doi.org/10.1002/anbr.202170023\">10.1002/anbr.202170023</a>","ieee":"Y. Xin, G. Grundmeier, and A. Keller, “Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.,” <i>Advanced NanoBiomed Research</i>, vol. 1, no. 2, p. 2170023, 2021.","apa":"Xin, Y., Grundmeier, G., &#38; Keller, A. (2021). Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy. <i>Advanced NanoBiomed Research</i>, <i>1</i>(2), 2170023. <a href=\"https://doi.org/10.1002/anbr.202170023\">https://doi.org/10.1002/anbr.202170023</a>","short":"Y. Xin, G. Grundmeier, A. Keller, Advanced NanoBiomed Research 1 (2021) 2170023.","chicago":"Xin, Y, Guido Grundmeier, and Adrian Keller. “Adsorption of SARS-CoV-2 Spike Protein S1 at Oxide Surfaces Studied by High-Speed Atomic Force Microscopy.” <i>Advanced NanoBiomed Research</i> 1, no. 2 (2021): 2170023. <a href=\"https://doi.org/10.1002/anbr.202170023\">https://doi.org/10.1002/anbr.202170023</a>."}},{"volume":535,"doi":"10.1016/j.apsusc.2020.147671","user_id":"48864","language":[{"iso":"eng"}],"_id":"22643","page":"147671","intvolume":"       535","date_updated":"2022-01-06T06:55:37Z","publication_status":"published","author":[{"first_name":"Yu","last_name":"Yang","full_name":"Yang, Yu"},{"last_name":"Yu","first_name":"Mingrui","full_name":"Yu, Mingrui"},{"full_name":"Böke, Frederik","first_name":"Frederik","last_name":"Böke"},{"full_name":"Qin, Qin","last_name":"Qin","first_name":"Qin"},{"full_name":"Hübner, René","last_name":"Hübner","first_name":"René"},{"full_name":"Knust, Steffen","first_name":"Steffen","last_name":"Knust"},{"last_name":"Schwiderek","first_name":"Sabrina","full_name":"Schwiderek, Sabrina"},{"full_name":"Grundmeier, Guido","last_name":"Grundmeier","first_name":"Guido","id":"194"},{"full_name":"Fischer, Horst","first_name":"Horst","last_name":"Fischer"},{"id":"48864","first_name":"Adrian","last_name":"Keller","orcid":"0000-0001-7139-3110","full_name":"Keller, Adrian"}],"publication_identifier":{"issn":["0169-4332"]},"title":"Effect of nanoscale surface topography on the adsorption of globular proteins","year":"2021","status":"public","department":[{"_id":"302"}],"type":"journal_article","date_created":"2021-07-08T11:57:33Z","citation":{"ieee":"Y. Yang <i>et al.</i>, “Effect of nanoscale surface topography on the adsorption of globular proteins,” <i>Applied Surface Science</i>, vol. 535, p. 147671, 2021.","apa":"Yang, Y., Yu, M., Böke, F., Qin, Q., Hübner, R., Knust, S., … Keller, A. (2021). Effect of nanoscale surface topography on the adsorption of globular proteins. <i>Applied Surface Science</i>, <i>535</i>, 147671. <a href=\"https://doi.org/10.1016/j.apsusc.2020.147671\">https://doi.org/10.1016/j.apsusc.2020.147671</a>","chicago":"Yang, Yu, Mingrui Yu, Frederik Böke, Qin Qin, René Hübner, Steffen Knust, Sabrina Schwiderek, Guido Grundmeier, Horst Fischer, and Adrian Keller. “Effect of Nanoscale Surface Topography on the Adsorption of Globular Proteins.” <i>Applied Surface Science</i> 535 (2021): 147671. <a href=\"https://doi.org/10.1016/j.apsusc.2020.147671\">https://doi.org/10.1016/j.apsusc.2020.147671</a>.","short":"Y. Yang, M. Yu, F. Böke, Q. Qin, R. Hübner, S. Knust, S. Schwiderek, G. Grundmeier, H. Fischer, A. Keller, Applied Surface Science 535 (2021) 147671.","mla":"Yang, Yu, et al. “Effect of Nanoscale Surface Topography on the Adsorption of Globular Proteins.” <i>Applied Surface Science</i>, vol. 535, 2021, p. 147671, doi:<a href=\"https://doi.org/10.1016/j.apsusc.2020.147671\">10.1016/j.apsusc.2020.147671</a>.","bibtex":"@article{Yang_Yu_Böke_Qin_Hübner_Knust_Schwiderek_Grundmeier_Fischer_Keller_2021, title={Effect of nanoscale surface topography on the adsorption of globular proteins}, volume={535}, DOI={<a href=\"https://doi.org/10.1016/j.apsusc.2020.147671\">10.1016/j.apsusc.2020.147671</a>}, journal={Applied Surface Science}, author={Yang, Yu and Yu, Mingrui and Böke, Frederik and Qin, Qin and Hübner, René and Knust, Steffen and Schwiderek, Sabrina and Grundmeier, Guido and Fischer, Horst and Keller, Adrian}, year={2021}, pages={147671} }","ama":"Yang Y, Yu M, Böke F, et al. Effect of nanoscale surface topography on the adsorption of globular proteins. <i>Applied Surface Science</i>. 2021;535:147671. doi:<a href=\"https://doi.org/10.1016/j.apsusc.2020.147671\">10.1016/j.apsusc.2020.147671</a>"},"publication":"Applied Surface Science"},{"date_updated":"2022-01-06T06:55:38Z","publication_status":"published","year":"2021","status":"public","title":"Effect of PAA-induced surface etching on the adhesion properties of ZnO nanostructured films","author":[{"id":"32378","full_name":"Meinderink, Dennis","first_name":"Dennis","last_name":"Meinderink","orcid":"0000-0002-2755-6514"},{"full_name":"Kielar, C.","last_name":"Kielar","first_name":"C."},{"last_name":"Sobol","first_name":"O.","full_name":"Sobol, O."},{"full_name":"Ruhm, L.","last_name":"Ruhm","first_name":"L."},{"full_name":"Rieker, F.","first_name":"F.","last_name":"Rieker"},{"full_name":"Nolkemper, K.","last_name":"Nolkemper","first_name":"K."},{"last_name":"Orive","first_name":"A.G.","full_name":"Orive, A.G."},{"first_name":"O.","last_name":"Ozcan","full_name":"Ozcan, O."},{"last_name":"Grundmeier","first_name":"Guido","full_name":"Grundmeier, Guido","id":"194"}],"publication_identifier":{"issn":["0143-7496"]},"doi":"10.1016/j.ijadhadh.2021.102812","user_id":"32378","article_number":"102812","_id":"22688","language":[{"iso":"eng"}],"publication":"International Journal of Adhesion and Adhesives","citation":{"mla":"Meinderink, Dennis, et al. “Effect of PAA-Induced Surface Etching on the Adhesion Properties of ZnO Nanostructured Films.” <i>International Journal of Adhesion and Adhesives</i>, 102812, 2021, doi:<a href=\"https://doi.org/10.1016/j.ijadhadh.2021.102812\">10.1016/j.ijadhadh.2021.102812</a>.","ama":"Meinderink D, Kielar C, Sobol O, et al. Effect of PAA-induced surface etching on the adhesion properties of ZnO nanostructured films. <i>International Journal of Adhesion and Adhesives</i>. 2021. doi:<a href=\"https://doi.org/10.1016/j.ijadhadh.2021.102812\">10.1016/j.ijadhadh.2021.102812</a>","bibtex":"@article{Meinderink_Kielar_Sobol_Ruhm_Rieker_Nolkemper_Orive_Ozcan_Grundmeier_2021, title={Effect of PAA-induced surface etching on the adhesion properties of ZnO nanostructured films}, DOI={<a href=\"https://doi.org/10.1016/j.ijadhadh.2021.102812\">10.1016/j.ijadhadh.2021.102812</a>}, number={102812}, journal={International Journal of Adhesion and Adhesives}, author={Meinderink, Dennis and Kielar, C. and Sobol, O. and Ruhm, L. and Rieker, F. and Nolkemper, K. and Orive, A.G. and Ozcan, O. and Grundmeier, Guido}, year={2021} }","apa":"Meinderink, D., Kielar, C., Sobol, O., Ruhm, L., Rieker, F., Nolkemper, K., … Grundmeier, G. (2021). Effect of PAA-induced surface etching on the adhesion properties of ZnO nanostructured films. <i>International Journal of Adhesion and Adhesives</i>. <a href=\"https://doi.org/10.1016/j.ijadhadh.2021.102812\">https://doi.org/10.1016/j.ijadhadh.2021.102812</a>","ieee":"D. Meinderink <i>et al.</i>, “Effect of PAA-induced surface etching on the adhesion properties of ZnO nanostructured films,” <i>International Journal of Adhesion and Adhesives</i>, 2021.","chicago":"Meinderink, Dennis, C. Kielar, O. Sobol, L. Ruhm, F. Rieker, K. Nolkemper, A.G. Orive, O. Ozcan, and Guido Grundmeier. “Effect of PAA-Induced Surface Etching on the Adhesion Properties of ZnO Nanostructured Films.” <i>International Journal of Adhesion and Adhesives</i>, 2021. <a href=\"https://doi.org/10.1016/j.ijadhadh.2021.102812\">https://doi.org/10.1016/j.ijadhadh.2021.102812</a>.","short":"D. Meinderink, C. Kielar, O. Sobol, L. Ruhm, F. Rieker, K. Nolkemper, A.G. Orive, O. Ozcan, G. Grundmeier, International Journal of Adhesion and Adhesives (2021)."},"type":"journal_article","department":[{"_id":"302"}],"date_created":"2021-07-09T12:14:26Z"},{"publication_status":"published","date_updated":"2022-01-06T06:55:38Z","title":"In situ backside Raman spectroscopy of zinc oxide nanorods in an atmospheric‐pressure dielectric barrier discharge plasma","status":"public","year":"2021","author":[{"last_name":"Knust","first_name":"Steffen","full_name":"Knust, Steffen"},{"last_name":"Ruhm","first_name":"Lukas","full_name":"Ruhm, Lukas"},{"last_name":"Kuhlmann","first_name":"Andreas","full_name":"Kuhlmann, Andreas"},{"first_name":"Dennis","last_name":"Meinderink","orcid":"0000-0002-2755-6514","full_name":"Meinderink, Dennis","id":"32378"},{"id":"46952","full_name":"Bürger, Julius","last_name":"Bürger","first_name":"Julius"},{"last_name":"Lindner","first_name":"Jörg K. N.","full_name":"Lindner, Jörg K. N."},{"last_name":"Arcos de Pedro","first_name":"Maria Teresa","full_name":"Arcos de Pedro, Maria Teresa"},{"id":"194","full_name":"Grundmeier, Guido","last_name":"Grundmeier","first_name":"Guido"}],"publication_identifier":{"issn":["0377-0486","1097-4555"]},"user_id":"32378","doi":"10.1002/jrs.6123","page":"1237-1245","language":[{"iso":"eng"}],"_id":"22697","publication":"Journal of Raman Spectroscopy","citation":{"mla":"Knust, Steffen, et al. “In Situ Backside Raman Spectroscopy of Zinc Oxide Nanorods in an Atmospheric‐pressure Dielectric Barrier Discharge Plasma.” <i>Journal of Raman Spectroscopy</i>, 2021, pp. 1237–45, doi:<a href=\"https://doi.org/10.1002/jrs.6123\">10.1002/jrs.6123</a>.","bibtex":"@article{Knust_Ruhm_Kuhlmann_Meinderink_Bürger_Lindner_Arcos de Pedro_Grundmeier_2021, title={In situ backside Raman spectroscopy of zinc oxide nanorods in an atmospheric‐pressure dielectric barrier discharge plasma}, DOI={<a href=\"https://doi.org/10.1002/jrs.6123\">10.1002/jrs.6123</a>}, journal={Journal of Raman Spectroscopy}, author={Knust, Steffen and Ruhm, Lukas and Kuhlmann, Andreas and Meinderink, Dennis and Bürger, Julius and Lindner, Jörg K. N. and Arcos de Pedro, Maria Teresa and Grundmeier, Guido}, year={2021}, pages={1237–1245} }","ama":"Knust S, Ruhm L, Kuhlmann A, et al. In situ backside Raman spectroscopy of zinc oxide nanorods in an atmospheric‐pressure dielectric barrier discharge plasma. <i>Journal of Raman Spectroscopy</i>. 2021:1237-1245. doi:<a href=\"https://doi.org/10.1002/jrs.6123\">10.1002/jrs.6123</a>","ieee":"S. Knust <i>et al.</i>, “In situ backside Raman spectroscopy of zinc oxide nanorods in an atmospheric‐pressure dielectric barrier discharge plasma,” <i>Journal of Raman Spectroscopy</i>, pp. 1237–1245, 2021.","apa":"Knust, S., Ruhm, L., Kuhlmann, A., Meinderink, D., Bürger, J., Lindner, J. K. N., … Grundmeier, G. (2021). In situ backside Raman spectroscopy of zinc oxide nanorods in an atmospheric‐pressure dielectric barrier discharge plasma. <i>Journal of Raman Spectroscopy</i>, 1237–1245. <a href=\"https://doi.org/10.1002/jrs.6123\">https://doi.org/10.1002/jrs.6123</a>","chicago":"Knust, Steffen, Lukas Ruhm, Andreas Kuhlmann, Dennis Meinderink, Julius Bürger, Jörg K. N. Lindner, Maria Teresa Arcos de Pedro, and Guido Grundmeier. “In Situ Backside Raman Spectroscopy of Zinc Oxide Nanorods in an Atmospheric‐pressure Dielectric Barrier Discharge Plasma.” <i>Journal of Raman Spectroscopy</i>, 2021, 1237–45. <a href=\"https://doi.org/10.1002/jrs.6123\">https://doi.org/10.1002/jrs.6123</a>.","short":"S. Knust, L. Ruhm, A. Kuhlmann, D. Meinderink, J. Bürger, J.K.N. Lindner, M.T. Arcos de Pedro, G. Grundmeier, Journal of Raman Spectroscopy (2021) 1237–1245."},"type":"journal_article","department":[{"_id":"302"}],"date_created":"2021-07-09T12:31:06Z"},{"title":"Ion Beam Nanopatterning of Biomaterial Surfaces","status":"public","year":"2021","publication_identifier":{"issn":["2076-3417"]},"author":[{"last_name":"Yang","first_name":"Yu","full_name":"Yang, Yu"},{"id":"48864","full_name":"Keller, Adrian","last_name":"Keller","first_name":"Adrian","orcid":"0000-0001-7139-3110"}],"date_updated":"2022-01-06T06:55:40Z","publication_status":"published","intvolume":"        11","page":"6575","language":[{"iso":"eng"}],"_id":"22773","doi":"10.3390/app11146575","user_id":"48864","volume":11,"publication":"Applied Sciences","citation":{"apa":"Yang, Y., &#38; Keller, A. (2021). Ion Beam Nanopatterning of Biomaterial Surfaces. <i>Applied Sciences</i>, <i>11</i>, 6575. <a href=\"https://doi.org/10.3390/app11146575\">https://doi.org/10.3390/app11146575</a>","ieee":"Y. Yang and A. Keller, “Ion Beam Nanopatterning of Biomaterial Surfaces,” <i>Applied Sciences</i>, vol. 11, p. 6575, 2021.","short":"Y. Yang, A. Keller, Applied Sciences 11 (2021) 6575.","chicago":"Yang, Yu, and Adrian Keller. “Ion Beam Nanopatterning of Biomaterial Surfaces.” <i>Applied Sciences</i> 11 (2021): 6575. <a href=\"https://doi.org/10.3390/app11146575\">https://doi.org/10.3390/app11146575</a>.","mla":"Yang, Yu, and Adrian Keller. “Ion Beam Nanopatterning of Biomaterial Surfaces.” <i>Applied Sciences</i>, vol. 11, 2021, p. 6575, doi:<a href=\"https://doi.org/10.3390/app11146575\">10.3390/app11146575</a>.","ama":"Yang Y, Keller A. Ion Beam Nanopatterning of Biomaterial Surfaces. <i>Applied Sciences</i>. 2021;11:6575. doi:<a href=\"https://doi.org/10.3390/app11146575\">10.3390/app11146575</a>","bibtex":"@article{Yang_Keller_2021, title={Ion Beam Nanopatterning of Biomaterial Surfaces}, volume={11}, DOI={<a href=\"https://doi.org/10.3390/app11146575\">10.3390/app11146575</a>}, journal={Applied Sciences}, author={Yang, Yu and Keller, Adrian}, year={2021}, pages={6575} }"},"abstract":[{"lang":"eng","text":"<jats:p>Ion beam irradiation of solid surfaces may result in the self-organized formation of well-defined topographic nanopatterns. Depending on the irradiation conditions and the material properties, isotropic or anisotropic patterns of differently shaped features may be obtained. Most intriguingly, the periodicities of these patterns can be adjusted in the range between less than twenty and several hundred nanometers, which covers the dimensions of many cellular and extracellular features. However, even though ion beam nanopatterning has been studied for several decades and is nowadays widely employed in the fabrication of functional surfaces, it has found its way into the biomaterials field only recently. This review provides a brief overview of the basics of ion beam nanopatterning, emphasizes aspects of particular relevance for biomaterials applications, and summarizes a number of recent studies that investigated the effects of such nanopatterned surfaces on the adsorption of biomolecules and the response of adhering cells. Finally, promising future directions and potential translational challenges are identified.</jats:p>"}],"date_created":"2021-07-21T09:25:55Z","type":"journal_article","department":[{"_id":"302"}]},{"volume":1,"user_id":"48864","_id":"22926","page":"129-139","status":"public","citation":{"apa":"Yang, Y., Schwiderek, S., Grundmeier, G., &#38; Keller, A. (2021). Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. <i>Micro</i>, <i>1</i>(1), 129–139. <a href=\"https://doi.org/10.3390/micro1010010\">https://doi.org/10.3390/micro1010010</a>","ieee":"Y. Yang, S. Schwiderek, G. Grundmeier, and A. Keller, “Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces,” <i>Micro</i>, vol. 1, no. 1, pp. 129–139, 2021.","chicago":"Yang, Yu, Sabrina Schwiderek, Guido Grundmeier, and Adrian Keller. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces.” <i>Micro</i> 1, no. 1 (2021): 129–39. <a href=\"https://doi.org/10.3390/micro1010010\">https://doi.org/10.3390/micro1010010</a>.","short":"Y. Yang, S. Schwiderek, G. Grundmeier, A. Keller, Micro 1 (2021) 129–139.","mla":"Yang, Yu, et al. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces.” <i>Micro</i>, vol. 1, no. 1, 2021, pp. 129–39, doi:<a href=\"https://doi.org/10.3390/micro1010010\">10.3390/micro1010010</a>.","ama":"Yang Y, Schwiderek S, Grundmeier G, Keller A. Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. <i>Micro</i>. 2021;1(1):129-139. doi:<a href=\"https://doi.org/10.3390/micro1010010\">10.3390/micro1010010</a>","bibtex":"@article{Yang_Schwiderek_Grundmeier_Keller_2021, title={Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces}, volume={1}, DOI={<a href=\"https://doi.org/10.3390/micro1010010\">10.3390/micro1010010</a>}, number={1}, journal={Micro}, author={Yang, Yu and Schwiderek, Sabrina and Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={129–139} }"},"doi":"10.3390/micro1010010","language":[{"iso":"eng"}],"intvolume":"         1","publication_status":"published","date_updated":"2022-01-06T06:55:43Z","publication_identifier":{"issn":["2673-8023"]},"author":[{"last_name":"Yang","first_name":"Yu","full_name":"Yang, Yu"},{"full_name":"Schwiderek, Sabrina","first_name":"Sabrina","last_name":"Schwiderek"},{"first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido","id":"194"},{"full_name":"Keller, Adrian","first_name":"Adrian","last_name":"Keller","orcid":"0000-0001-7139-3110","id":"48864"}],"title":"Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces","year":"2021","department":[{"_id":"302"}],"type":"journal_article","date_created":"2021-08-03T06:07:33Z","abstract":[{"lang":"eng","text":"<jats:p>Implant-associated infections are an increasingly severe burden on healthcare systems worldwide and many research activities currently focus on inhibiting microbial colonization of biomedically relevant surfaces. To obtain molecular-level understanding of the involved processes and interactions, we investigate the adsorption of synthetic adhesin-like peptide sequences derived from the type IV pili of the Pseudomonas aeruginosa strains PAK and PAO at abiotic model surfaces, i.e., Au, SiO2, and oxidized Ti. These peptides correspond to the sequences of the receptor-binding domain 128–144 of the major pilin protein, which is known to facilitate P. aeruginosa adhesion at biotic and abiotic surfaces. Using quartz crystal microbalance with dissipation monitoring (QCM-D), we find that peptide adsorption is material- as well as strain-dependent. At the Au surface, PAO(128–144) shows drastically stronger adsorption than PAK(128–144), whereas adsorption of both peptides is markedly reduced at the oxide surfaces with less drastic differences between the two sequences. These observations suggest that peptide adsorption is influenced by not only the peptide sequence, but also peptide conformation. Our results furthermore highlight the importance of molecular-level investigations to understand and ultimately control microbial colonization of surfaces.</jats:p>"}],"publication":"Micro","issue":"1"},{"department":[{"_id":"302"}],"type":"journal_article","date_created":"2021-08-09T06:17:59Z","abstract":[{"text":"<jats:p>DNA origami nanostructures (DONs) are promising substrates for the single-molecule investigation of biomolecular reactions and dynamics by in situ atomic force microscopy (AFM). For this, they are typically immobilized on mica substrates by adding millimolar concentrations of Mg2+ ions to the sample solution, which enable the adsorption of the negatively charged DONs at the like-charged mica surface. These non-physiological Mg2+ concentrations, however, present a serious limitation in such experiments as they may interfere with the reactions and processes under investigation. Therefore, we here evaluate three approaches to efficiently immobilize DONs at mica surfaces under essentially Mg2+-free conditions. These approaches rely on the pre-adsorption of different multivalent cations, i.e., Ni2+, poly-l-lysine (PLL), and spermidine (Spdn). DON adsorption is studied in phosphate-buffered saline (PBS) and pure water. In general, Ni2+ shows the worst performance with heavily deformed DONs. For 2D DON triangles, adsorption at PLL- and in particular Spdn-modified mica may outperform even Mg2+-mediated adsorption in terms of surface coverage, depending on the employed solution. For 3D six-helix bundles, less pronounced differences between the individual strategies are observed. Our results provide some general guidance for the immobilization of DONs at mica surfaces under Mg2+-free conditions and may aid future in situ AFM studies.</jats:p>","lang":"eng"}],"citation":{"mla":"Xin, Yang, et al. “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy.” <i>Molecules</i>, vol. 26, 2021, p. 4798, doi:<a href=\"https://doi.org/10.3390/molecules26164798\">10.3390/molecules26164798</a>.","ama":"Xin Y, Zargariantabrizi AA, Grundmeier G, Keller A. Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy. <i>Molecules</i>. 2021;26:4798. doi:<a href=\"https://doi.org/10.3390/molecules26164798\">10.3390/molecules26164798</a>","bibtex":"@article{Xin_Zargariantabrizi_Grundmeier_Keller_2021, title={Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy}, volume={26}, DOI={<a href=\"https://doi.org/10.3390/molecules26164798\">10.3390/molecules26164798</a>}, journal={Molecules}, author={Xin, Yang and Zargariantabrizi, Amir Ardalan and Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={4798} }","apa":"Xin, Y., Zargariantabrizi, A. A., Grundmeier, G., &#38; Keller, A. (2021). Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy. <i>Molecules</i>, <i>26</i>, 4798. <a href=\"https://doi.org/10.3390/molecules26164798\">https://doi.org/10.3390/molecules26164798</a>","ieee":"Y. Xin, A. A. Zargariantabrizi, G. Grundmeier, and A. Keller, “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy,” <i>Molecules</i>, vol. 26, p. 4798, 2021.","short":"Y. Xin, A.A. Zargariantabrizi, G. Grundmeier, A. Keller, Molecules 26 (2021) 4798.","chicago":"Xin, Yang, Amir Ardalan Zargariantabrizi, Guido Grundmeier, and Adrian Keller. “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy.” <i>Molecules</i> 26 (2021): 4798. <a href=\"https://doi.org/10.3390/molecules26164798\">https://doi.org/10.3390/molecules26164798</a>."},"publication":"Molecules","volume":26,"user_id":"48864","doi":"10.3390/molecules26164798","language":[{"iso":"eng"}],"_id":"23023","page":"4798","intvolume":"        26","publication_status":"published","date_updated":"2022-01-06T06:55:45Z","publication_identifier":{"issn":["1420-3049"]},"author":[{"last_name":"Xin","first_name":"Yang","full_name":"Xin, Yang"},{"last_name":"Zargariantabrizi","first_name":"Amir Ardalan","full_name":"Zargariantabrizi, Amir Ardalan"},{"full_name":"Grundmeier, Guido","last_name":"Grundmeier","first_name":"Guido","id":"194"},{"id":"48864","full_name":"Keller, Adrian","orcid":"0000-0001-7139-3110","first_name":"Adrian","last_name":"Keller"}],"title":"Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy","year":"2021","status":"public"},{"type":"conference","department":[{"_id":"157"},{"_id":"302"}],"date_created":"2021-04-22T10:19:48Z","citation":{"apa":"Schmolke, T., Teutenberg, D., Meschut, G., Meinderink, D., Koch, L., Ebbert, C., &#38; Grundmeier, G. (2021). Entwicklung einer Methode zur Bewertung einer stahlintensiven Mischbau-Klebverbindung eines Batteriegehäuses gegenüber mechanischer und medialer Belastung und Berücksichtigung der Interphasenstruktur. In DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V. (Ed.). Presented at the 21. Kolloquium Gemeinsame Forschung in der Klebtechnik , Online Event.","ieee":"T. Schmolke <i>et al.</i>, “Entwicklung einer Methode zur Bewertung einer stahlintensiven Mischbau-Klebverbindung eines Batteriegehäuses gegenüber mechanischer und medialer Belastung und Berücksichtigung der Interphasenstruktur,” presented at the 21. Kolloquium Gemeinsame Forschung in der Klebtechnik , Online Event, 2021.","chicago":"Schmolke, Tobias, Dominik Teutenberg, Gerson Meschut, Dennis Meinderink, Leon  Koch, Christoph Ebbert, and Guido Grundmeier. “Entwicklung Einer Methode Zur Bewertung Einer Stahlintensiven Mischbau-Klebverbindung Eines Batteriegehäuses Gegenüber Mechanischer Und Medialer Belastung Und Berücksichtigung Der Interphasenstruktur.” edited by DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V., 2021.","short":"T. Schmolke, D. Teutenberg, G. Meschut, D. Meinderink, L. Koch, C. Ebbert, G. Grundmeier, in: DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V. (Ed.), 2021.","mla":"Schmolke, Tobias, et al. <i>Entwicklung Einer Methode Zur Bewertung Einer Stahlintensiven Mischbau-Klebverbindung Eines Batteriegehäuses Gegenüber Mechanischer Und Medialer Belastung Und Berücksichtigung Der Interphasenstruktur</i>. Edited by DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V., 2021.","ama":"Schmolke T, Teutenberg D, Meschut G, et al. Entwicklung einer Methode zur Bewertung einer stahlintensiven Mischbau-Klebverbindung eines Batteriegehäuses gegenüber mechanischer und medialer Belastung und Berücksichtigung der Interphasenstruktur. In: DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V., ed. ; 2021.","bibtex":"@inproceedings{Schmolke_Teutenberg_Meschut_Meinderink_Koch_Ebbert_Grundmeier_2021, title={Entwicklung einer Methode zur Bewertung einer stahlintensiven Mischbau-Klebverbindung eines Batteriegehäuses gegenüber mechanischer und medialer Belastung und Berücksichtigung der Interphasenstruktur}, author={Schmolke, Tobias and Teutenberg, Dominik and Meschut, Gerson and Meinderink, Dennis and Koch, Leon  and Ebbert, Christoph and Grundmeier, Guido}, editor={DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V.Editor}, year={2021} }"},"user_id":"7266","language":[{"iso":"eng"}],"_id":"21717","date_updated":"2022-01-06T06:55:11Z","title":"Entwicklung einer Methode zur Bewertung einer stahlintensiven Mischbau-Klebverbindung eines Batteriegehäuses gegenüber mechanischer und medialer Belastung und Berücksichtigung der Interphasenstruktur","status":"public","year":"2021","conference":{"start_date":"2021-03-02","name":"21. 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N."},{"id":"54556","full_name":"de los Arcos de Pedro, Maria Teresa","first_name":"Maria Teresa","last_name":"de los Arcos de Pedro"},{"id":"194","last_name":"Grundmeier","first_name":"Guido","full_name":"Grundmeier, Guido"}],"publication_identifier":{"issn":["0377-0486","1097-4555"]},"doi":"10.1002/jrs.6123","user_id":"54556","page":"1237-1245","_id":"22535","language":[{"iso":"eng"}]},{"title":"Review of infrared spectroscopy techniques for the determination of internal structure in thin SiO2 films","status":"public","year":"2021","author":[{"full_name":"de los Arcos, Teresa","last_name":"de los Arcos","first_name":"Teresa"},{"last_name":"Müller","first_name":"Hendrik","full_name":"Müller, Hendrik"},{"full_name":"Wang, Fuzeng","first_name":"Fuzeng","last_name":"Wang"},{"full_name":"Damerla, Varun Raj","first_name":"Varun Raj","last_name":"Damerla"},{"last_name":"Hoppe","first_name":"Christian","full_name":"Hoppe, Christian"},{"full_name":"Weinberger, Christian","first_name":"Christian","last_name":"Weinberger","id":"11848"},{"orcid":"0000-0003-1711-2722","first_name":"Michael","last_name":"Tiemann","full_name":"Tiemann, Michael","id":"23547"},{"id":"194","first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido"}],"publication_identifier":{"issn":["0924-2031"]},"date_updated":"2023-03-07T10:44:06Z","publication_status":"published","article_type":"original","article_number":"103256","_id":"25897","language":[{"iso":"eng"}],"doi":"10.1016/j.vibspec.2021.103256","user_id":"23547","publication":"Vibrational Spectroscopy","citation":{"bibtex":"@article{de los Arcos_Müller_Wang_Damerla_Hoppe_Weinberger_Tiemann_Grundmeier_2021, title={Review of infrared spectroscopy techniques for the determination of internal structure in thin SiO2 films}, DOI={<a href=\"https://doi.org/10.1016/j.vibspec.2021.103256\">10.1016/j.vibspec.2021.103256</a>}, number={103256}, journal={Vibrational Spectroscopy}, author={de los Arcos, Teresa and Müller, Hendrik and Wang, Fuzeng and Damerla, Varun Raj and Hoppe, Christian and Weinberger, Christian and Tiemann, Michael and Grundmeier, Guido}, year={2021} }","ama":"de los Arcos T, Müller H, Wang F, et al. Review of infrared spectroscopy techniques for the determination of internal structure in thin SiO2 films. <i>Vibrational Spectroscopy</i>. Published online 2021. doi:<a href=\"https://doi.org/10.1016/j.vibspec.2021.103256\">10.1016/j.vibspec.2021.103256</a>","mla":"de los Arcos, Teresa, et al. “Review of Infrared Spectroscopy Techniques for the Determination of Internal Structure in Thin SiO2 Films.” <i>Vibrational Spectroscopy</i>, 103256, 2021, doi:<a href=\"https://doi.org/10.1016/j.vibspec.2021.103256\">10.1016/j.vibspec.2021.103256</a>.","chicago":"Arcos, Teresa de los, Hendrik Müller, Fuzeng Wang, Varun Raj Damerla, Christian Hoppe, Christian Weinberger, Michael Tiemann, and Guido Grundmeier. “Review of Infrared Spectroscopy Techniques for the Determination of Internal Structure in Thin SiO2 Films.” <i>Vibrational Spectroscopy</i>, 2021. <a href=\"https://doi.org/10.1016/j.vibspec.2021.103256\">https://doi.org/10.1016/j.vibspec.2021.103256</a>.","short":"T. de los Arcos, H. Müller, F. Wang, V.R. Damerla, C. Hoppe, C. Weinberger, M. Tiemann, G. Grundmeier, Vibrational Spectroscopy (2021).","ieee":"T. de los Arcos <i>et al.</i>, “Review of infrared spectroscopy techniques for the determination of internal structure in thin SiO2 films,” <i>Vibrational Spectroscopy</i>, Art. no. 103256, 2021, doi: <a href=\"https://doi.org/10.1016/j.vibspec.2021.103256\">10.1016/j.vibspec.2021.103256</a>.","apa":"de los Arcos, T., Müller, H., Wang, F., Damerla, V. R., Hoppe, C., Weinberger, C., Tiemann, M., &#38; Grundmeier, G. (2021). Review of infrared spectroscopy techniques for the determination of internal structure in thin SiO2 films. <i>Vibrational Spectroscopy</i>, Article 103256. <a href=\"https://doi.org/10.1016/j.vibspec.2021.103256\">https://doi.org/10.1016/j.vibspec.2021.103256</a>"},"abstract":[{"text":"A comparison of infrared spectroscopic analytical approaches was made in order to assess their applicability for internal structure characterization of SiO2 thin films. Markers for porosity and/or disorder based on the analysis of the asymmetric stretching absorption band of SiO2 between 900−1350 cm−1 were discussed. The shape of this band, which shows a well-defined LO–TO splitting, depends not only on the inherent characteristics of the film under analysis but also on the particular geometry of the IR experiment and the specific surface selection rules of the substrate. Three types of SiO2 thin films with clearly defined porosity ranging from dense films to mesoporous films were investigated by transmission (at different incidence angles), direct specular reflection (at different angles), and diffuse reflection. Two different types of substrate, metallic and semiconducting, were used. The combined effect of substrate and specific technique in the final shape of the band, was discussed, and the efficacy for their applicability to the determination of porosity in thin SiO2 films was critically evaluated.","lang":"eng"}],"quality_controlled":"1","date_created":"2021-10-08T10:09:45Z","type":"journal_article","department":[{"_id":"35"},{"_id":"2"},{"_id":"307"},{"_id":"302"}]},{"doi":"10.1002/jbm.b.34862","language":[{"iso":"eng"}],"article_type":"original","intvolume":"       109","publication_status":"published","date_updated":"2023-03-08T08:10:25Z","publication_identifier":{"issn":["1552-4973","1552-4981"]},"author":[{"first_name":"Jaime Andres","last_name":"Garcia Diosa","full_name":"Garcia Diosa, Jaime Andres"},{"full_name":"Gonzalez Orive, Alejandro","last_name":"Gonzalez Orive","first_name":"Alejandro"},{"id":"11848","last_name":"Weinberger","first_name":"Christian","full_name":"Weinberger, Christian"},{"first_name":"Sabrina","last_name":"Schwiderek","full_name":"Schwiderek, Sabrina"},{"full_name":"Knust, Steffen","first_name":"Steffen","last_name":"Knust"},{"id":"23547","full_name":"Tiemann, Michael","orcid":"0000-0003-1711-2722","last_name":"Tiemann","first_name":"Michael"},{"first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido","id":"194"},{"full_name":"Keller, Adrian","orcid":"0000-0001-7139-3110","first_name":"Adrian","last_name":"Keller","id":"48864"},{"first_name":"Ruben Jesus","last_name":"Camargo Amado","full_name":"Camargo Amado, Ruben Jesus"}],"year":"2021","title":"TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood","department":[{"_id":"302"},{"_id":"307"},{"_id":"35"},{"_id":"2"}],"type":"journal_article","date_created":"2021-07-08T11:34:21Z","abstract":[{"text":"Photodynamic therapy (PDT) using TiO2 nanoparticles has become an important alternative treatment for different types of cancer due to their high photocatalytic activity and high absorption of UV-A light. To potentiate this treatment, we have coated commercial glass plates with TiO2 nanoparticles prepared by the sol–gel method (TiO2-m), which exhibit a remarkable selectivity for the irreversible trapping of cancer cells. The physicochemical properties of the deposited TiO2-m nanoparticle coatings have been characterized by a number of complementary surface-analytical techniques and their interaction with leukemia and healthy blood cells were investigated. Scanning electron and atomic force microscopy verify the formation of a compact layer of TiO2-m nanoparticles. The particles are predominantly in the anatase phase and have hydroxyl-terminated surfaces as revealed by Raman, X-ray photoelectron, and infrared spectroscopy, as well as X-ray diffraction. We find that lymphoblastic leukemia cells adhere to the TiO2-m coating and undergo amoeboid-like migration, whereas lymphocytic cells show distinctly weaker interactions with the coating. This evidences the potential of this nanomaterial coating to selectively trap cancer cells and renders it a promising candidate for the development of future prototypes of PDT devices for the treatment of leukemia and other types of cancers with non-adherent cells.","lang":"eng"}],"publication":"Journal of Biomedical Materials Research Part B: Applied Biomaterials","volume":109,"user_id":"23547","_id":"22635","page":"2142–2153","status":"public","quality_controlled":"1","citation":{"ama":"Garcia Diosa JA, Gonzalez Orive A, Weinberger C, et al. TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood. <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i>. 2021;109:2142–2153. doi:<a href=\"https://doi.org/10.1002/jbm.b.34862\">10.1002/jbm.b.34862</a>","bibtex":"@article{Garcia Diosa_Gonzalez Orive_Weinberger_Schwiderek_Knust_Tiemann_Grundmeier_Keller_Camargo Amado_2021, title={TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood}, volume={109}, DOI={<a href=\"https://doi.org/10.1002/jbm.b.34862\">10.1002/jbm.b.34862</a>}, journal={Journal of Biomedical Materials Research Part B: Applied Biomaterials}, author={Garcia Diosa, Jaime Andres and Gonzalez Orive, Alejandro and Weinberger, Christian and Schwiderek, Sabrina and Knust, Steffen and Tiemann, Michael and Grundmeier, Guido and Keller, Adrian and Camargo Amado, Ruben Jesus}, year={2021}, pages={2142–2153} }","mla":"Garcia Diosa, Jaime Andres, et al. “TiO2 Nanoparticle Coatings on Glass Surfaces for the Selective Trapping of Leukemia Cells from Peripheral Blood.” <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i>, vol. 109, 2021, pp. 2142–2153, doi:<a href=\"https://doi.org/10.1002/jbm.b.34862\">10.1002/jbm.b.34862</a>.","short":"J.A. Garcia Diosa, A. Gonzalez Orive, C. Weinberger, S. Schwiderek, S. Knust, M. Tiemann, G. Grundmeier, A. Keller, R.J. Camargo Amado, Journal of Biomedical Materials Research Part B: Applied Biomaterials 109 (2021) 2142–2153.","chicago":"Garcia Diosa, Jaime Andres, Alejandro Gonzalez Orive, Christian Weinberger, Sabrina Schwiderek, Steffen Knust, Michael Tiemann, Guido Grundmeier, Adrian Keller, and Ruben Jesus Camargo Amado. “TiO2 Nanoparticle Coatings on Glass Surfaces for the Selective Trapping of Leukemia Cells from Peripheral Blood.” <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i> 109 (2021): 2142–2153. <a href=\"https://doi.org/10.1002/jbm.b.34862\">https://doi.org/10.1002/jbm.b.34862</a>.","apa":"Garcia Diosa, J. A., Gonzalez Orive, A., Weinberger, C., Schwiderek, S., Knust, S., Tiemann, M., Grundmeier, G., Keller, A., &#38; Camargo Amado, R. J. (2021). TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood. <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i>, <i>109</i>, 2142–2153. <a href=\"https://doi.org/10.1002/jbm.b.34862\">https://doi.org/10.1002/jbm.b.34862</a>","ieee":"J. A. Garcia Diosa <i>et al.</i>, “TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood,” <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i>, vol. 109, pp. 2142–2153, 2021, doi: <a href=\"https://doi.org/10.1002/jbm.b.34862\">10.1002/jbm.b.34862</a>."}}]