This chapter examines the fundamental neurophysiological principles involved in determining electroencephalographic (EEG) artifact and provides general instructions for minimizing the risk of error during clinical interpretation. Examples from EEG recordings are given to illustrate common artifacts that may be challenging to the reader because they mimic epileptiform pattern associated to people with epilepsy. Emerging techniques used to detect and reduce artifact without altering the electrocerebral signal are being developed to limit the contamination. While many artifacts are easy to recognize, more complex waveforms may confuse even the most experienced reader. Constant vigilance and a team effort to minimize artifact will help to ensure a proper interpretation of the EEG for optimal patient care.
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