@article{25605,
  abstract     = {{The nonlinear process of second harmonic generation (SHG) in monolayer (1L) transition metal dichalcogenides (TMD), like WS2, strongly depends on the polarization state of the excitation light. By combination of plasmonic nanostructures with 1L-WS2 by transferring it onto a plasmonic nanoantenna array, a hybrid metasurface is realized impacting the polarization dependency of its SHG. Here, we investigate how plasmonic dipole resonances affect the process of SHG in plasmonic–TMD hybrid metasurfaces by nonlinear spectroscopy. We show that the polarization dependency is affected by the lattice structure of plasmonic nanoantenna arrays as well as by the relative orientation between the 1L-WS2 and the individual plasmonic nanoantennas. In addition, such hybrid metasurfaces show SHG in polarization states, where SHG is usually forbidden for either 1L-WS2 or plasmonic nanoantennas. By comparing the SHG in these channels with the SHG generated by the hybrid metasurface components, we detect an enhancement of the SHG signal by a factor of more than 40. Meanwhile, an attenuation of the SHG signal in usually allowed polarization states is observed. Our study provides valuable insight into hybrid systems where symmetries strongly affect the SHG and enable tailored SHG in 1L-WS2 for future applications.}},
  author       = {{Spreyer, Florian and Ruppert, Claudia and Georgi, Philip and Zentgraf, Thomas}},
  issn         = {{1936-0851}},
  journal      = {{ACS Nano}},
  number       = {{10}},
  pages        = {{16719--16728}},
  title        = {{{Influence of Plasmon Resonances and Symmetry Effects on Second Harmonic Generation in WS2–Plasmonic Hybrid Metasurfaces}}},
  doi          = {{10.1021/acsnano.1c06693}},
  volume       = {{15}},
  year         = {{2021}},
}

@article{27970,
  author       = {{Barclay, AW and LSA, Augustin and Brighenti, F and Delport, E and Henry, CJ and Sievenpiper, JL and Usic, K and Yuexin, Y and Zurbau, A and TMS, Wolever and Astrup, A and Bulló, M and Buyken, Anette and Ceriello, A and Ellis, PR and Vanginkel, MA and CWC, Kendall and La Vecchia, C and Livesey, G and Poli, A and Riccardi, G and Salas-Salvadó, J and Trichopoulou, A and Bhaskaran, K and DJA, Jenkins and Willett, WC and Brand-Miller, JC}},
  issn         = {{2072-6643}},
  journal      = {{Nutrients}},
  number       = {{9}},
  title        = {{{Dietary Glycaemic Index Labelling: A Global Perspective.}}},
  doi          = {{10.3390/nu13093244}},
  volume       = {{13}},
  year         = {{2021}},
}

@article{28198,
  author       = {{Steinrück, Hans-Georg}},
  issn         = {{2158-3226}},
  journal      = {{AIP Advances}},
  number       = {{11}},
  pages        = {{115119}},
  title        = {{{General relationship between salt concentration and x-ray absorption for binary electrolytes}}},
  doi          = {{10.1063/5.0072947}},
  volume       = {{11}},
  year         = {{2021}},
}

@article{26011,
  author       = {{Hense, Dominik and Büngeler, Anne and Kollmann, Fabian and Hanke, Marcel and Orive, Alejandro and Keller, Adrian and Grundmeier, Guido and Huber, Klaus and Strube, Oliver I.}},
  issn         = {{1525-7797}},
  journal      = {{Biomacromolecules}},
  pages        = {{4084–4094}},
  title        = {{{Self-Assembled Fibrinogen Hydro- and Aerogels with Fibrin-like 3D Structures}}},
  doi          = {{10.1021/acs.biomac.1c00489}},
  volume       = {{22}},
  year         = {{2021}},
}

@article{26012,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
                <jats:title>Purpose</jats:title>
                <jats:p>Exhaustive cardiovascular load can affect neural processing and is associated with decreases in sensorimotor performance. The purpose of this study was to explore intensity-dependent modulations in brain network efficiency in response to treadmill running assessed from resting-state electroencephalography (EEG) measures.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Methods</jats:title>
                <jats:p>Sixteen trained participants were tested for individual peak oxygen uptake (VO<jats:sub>2 peak</jats:sub>) and performed an incremental treadmill exercise at 50% (10 min), 70% (10 min) and 90% speed VO<jats:sub>2 peak</jats:sub> (all-out) followed by cool-down running and active recovery. Before the experiment and after each stage, borg scale (BS), blood lactate concentration (B<jats:sub>La</jats:sub>), resting heartrate (HR<jats:sub>rest</jats:sub>) and 64-channel EEG resting state were assessed. To analyze network efficiency, graph theory was applied to derive small world index (SWI) from EEG data in theta, alpha-1 and alpha-2 frequency bands.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Results</jats:title>
                <jats:p>Analysis of variance for repeated measures revealed significant main effects for intensity on BS, B<jats:sub>La</jats:sub>, HR<jats:sub>rest</jats:sub> and SWI. While BS, B<jats:sub>La</jats:sub> and HR<jats:sub>rest</jats:sub> indicated maxima after all-out, SWI showed a reduction in the theta network after all-out.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Conclusion</jats:title>
                <jats:p>Our explorative approach suggests intensity-dependent modulations of resting-state brain networks, since exhaustive exercise temporarily reduces brain network efficiency. Resting-state network assessment may prospectively play a role in training monitoring by displaying the readiness and efficiency of the central nervous system in different training situations.</jats:p>
              </jats:sec>}},
  author       = {{Büchel, Daniel and Sandbakk, Øyvind and Baumeister, Jochen}},
  issn         = {{1439-6319}},
  journal      = {{European Journal of Applied Physiology}},
  pages        = {{2423--2435}},
  title        = {{{Exploring intensity-dependent modulations in EEG resting-state network efficiency induced by exercise}}},
  doi          = {{10.1007/s00421-021-04712-6}},
  year         = {{2021}},
}

@article{26013,
  abstract     = {{<jats:title>Abstract </jats:title><jats:p>Mobile Electroencephalography (EEG) provides insights into cortical contributions to postural control. Although changes in theta (4–8 Hz) and alpha frequency power (8–12 Hz) were shown to reflect attentional and sensorimotor processing during balance tasks, information about the effect of stance leg on cortical processing related to postural control is lacking. Therefore, the aim was to examine patterns of cortical activity during single-leg stance with varying surface stability. EEG and force plate data from 21 healthy males (22.43 ± 2.23 years) was recorded during unipedal stance (left/right) on a stable and unstable surface. Using source-space analysis, power spectral density was analyzed in the theta, alpha-1 (8–10 Hz) and alpha-2 (10–12 Hz) frequency bands. Repeated measures ANOVA with the factors leg and surface stability revealed significant interaction effects in the left (<jats:italic>p</jats:italic> = 0.045, <jats:italic>η</jats:italic><jats:sub><jats:italic>p</jats:italic></jats:sub><jats:sup>2</jats:sup> = 0.13) and right motor clusters (<jats:italic>F</jats:italic> = 16.156; <jats:italic>p</jats:italic> = 0.001, <jats:italic>η</jats:italic><jats:sub><jats:italic>p</jats:italic></jats:sub><jats:sup>2</jats:sup> = 0.41). Furthermore, significant main effects for surface stability were observed for the fronto-central cluster (theta), left and right motor (alpha-1), as well as for the right parieto-occipital cluster (alpha-1/alpha-2). Leg dependent changes in alpha-2 power may indicate lateralized patterns of cortical processing in motor areas during single-leg stance. Future studies may therefore consider lateralized patterns of cortical activity for the interpretation of postural deficiencies in unilateral lower limb injuries.</jats:p>}},
  author       = {{Büchel, Daniel and Lehmann, Tim and Ullrich, Sarah and Cockcroft, John and Louw, Quinette and Baumeister, Jochen}},
  issn         = {{0014-4819}},
  journal      = {{Experimental Brain Research}},
  pages        = {{1193--1202}},
  title        = {{{Stance leg and surface stability modulate cortical activity during human single leg stance}}},
  doi          = {{10.1007/s00221-021-06035-6}},
  year         = {{2021}},
}

@article{26014,
  abstract     = {{<jats:p>Whereas initial findings have already identified cortical patterns accompanying proprioceptive deficiencies in patients after anterior cruciate ligament reconstruction (ACLR), little is known about compensatory sensorimotor mechanisms for re-establishing postural control. Therefore, the aim of the present study was to explore leg dependent patterns of cortical contributions to postural control in patients 6 weeks following ACLR. A total of 12 patients after ACLR (25.1 ± 3.2 years, 178.1 ± 9.7 cm, 77.5 ± 14.4 kg) and another 12 gender, age, and activity matched healthy controls participated in this study. All subjects performed 10 × 30 s. single leg stances on each leg, equipped with 64-channel mobile electroencephalography (EEG). Postural stability was quantified by area of sway and sway velocity. Estimations of the weighted phase lag index were conducted as a cortical measure of functional connectivity. The findings showed significant group × leg interactions for increased functional connectivity in the anterior cruciate ligament (ACL) injured leg, predominantly including fronto−parietal [<jats:italic>F</jats:italic><jats:sub>(1, 22)</jats:sub> = 8.41, <jats:italic>p</jats:italic> ≤ 0.008, η<jats:sup>2</jats:sup> = 0.28], fronto−occipital [<jats:italic>F</jats:italic><jats:sub>(1, 22)</jats:sub> = 4.43, <jats:italic>p</jats:italic> ≤ 0.047, η<jats:sup>2</jats:sup> = 0.17], parieto−motor [<jats:italic>F</jats:italic><jats:sub>(1, 22)</jats:sub> = 10.30, <jats:italic>p</jats:italic> ≤ 0.004, η<jats:sup>2</jats:sup> = 0.32], occipito−motor [<jats:italic>F</jats:italic><jats:sub>(1, 22)</jats:sub> = 5.21, <jats:italic>p</jats:italic> ≤ 0.032, η<jats:sup>2</jats:sup> = 0.19], and occipito−parietal [<jats:italic>F</jats:italic><jats:sub>(1, 22)</jats:sub> = 4.60, <jats:italic>p</jats:italic> ≤ 0.043, η<jats:sup>2</jats:sup> = 0.17] intra−hemispherical connections in the contralateral hemisphere and occipito−motor [<jats:italic>F</jats:italic><jats:sub>(1, 22)</jats:sub> = 7.33, <jats:italic>p</jats:italic> ≤ 0.013, η<jats:sup>2</jats:sup> = 0.25] on the ipsilateral hemisphere to the injured leg. Higher functional connectivity in patients after ACLR, attained by increased emphasis of functional connections incorporating the somatosensory and visual areas, may serve as a compensatory mechanism to control postural stability of the injured leg in the early phase of rehabilitation. These preliminary results may help to develop new neurophysiological assessments for detecting functional deficiencies after ACLR in the future.</jats:p>}},
  author       = {{Lehmann, Tim and Büchel, Daniel and Mouton, Caroline and Gokeler, Alli and Seil, Romain and Baumeister, Jochen}},
  issn         = {{1662-5161}},
  journal      = {{Frontiers in Human Neuroscience}},
  title        = {{{Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction}}},
  doi          = {{10.3389/fnhum.2021.655116}},
  year         = {{2021}},
}

@article{26039,
  author       = {{Lahme, Simon and Bauer, Anna and Reinhold, Peter}},
  journal      = {{Phydid B, Didaktik der Physik, Beiträge zur DPG-Frühjahrstagung}},
  pages        = {{127--134}},
  title        = {{{Ansätze zur Diagnose und Förderung von Problemlösefähigkeiten in der Studieneingangsphase Physik}}},
  year         = {{2021}},
}

@article{26420,
  author       = {{Hirtz, Raphael and Focker, Manuel and Libuda, Lars and Antel, Jochen and Ozturk, Dana and Kiewert, Cordula and Munteanu, Martin and Peters, Triinu and Fuhrer, Dagmar and Zwanziger, Denise and Thamm, Michael and Hebebrand, Johannes and Grasemann, Corinna}},
  issn         = {{1555-2101}},
  journal      = {{The Journal of Clinical Psychiatry}},
  title        = {{{Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents}}},
  doi          = {{10.4088/jcp.20m13511}},
  year         = {{2021}},
}

@article{26523,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN.</jats:p>}},
  author       = {{Antel, Jochen and Tan, Susanne and Grabler, Marvin and Ludwig, Christine and Lohkemper, Dominik and Brandenburg, Tim and Barth, Nikolaus and Hinney, Anke and Libuda, Lars and Remy, Miriam and Milos, Gabriella and Hebebrand, Johannes}},
  issn         = {{1018-8827}},
  journal      = {{European Child & Adolescent Psychiatry}},
  title        = {{{Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism}}},
  doi          = {{10.1007/s00787-021-01778-7}},
  year         = {{2021}},
}

@inbook{26633,
  author       = {{Schlegel-Matthies, Kirsten and Wespi, Claudia}},
  booktitle    = {{Wirksamer Fachunterricht. Eine metaanalytische Betrachtung von Expertisen aus 17 Schulfächern}},
  editor       = {{Reinhardt, V. and Rehm , M. and Wilhem , M.}},
  pages        = {{200--217}},
  publisher    = {{Baltmannsweiler: Schneider-Verlag}},
  title        = {{{Befähigung zur Reflexion und zum Umgang mit Ambiguitäten. Zur Wirksamkeit von Unterricht für "Lebensführung"}}},
  year         = {{2021}},
}

@book{26635,
  author       = {{Schlegel-Matthies, Kirsten and Wespi, Claudia}},
  isbn         = {{ISBN-13: 9783834020314}},
  pages        = {{245}},
  publisher    = {{Baltmannsweiler: Schneider-Verlag.}},
  title        = {{{Wirksamer Unterricht für Lebensführung. (Unterrichtsqualität: Perspektiven von Expertinnen und Experten 12) }}},
  volume       = {{12}},
  year         = {{2021}},
}

@inproceedings{26718,
  author       = {{Pollmeier, Pascal and Fechner, Sabine}},
  booktitle    = {{Naturwissenschaftlicher Unterricht und Lehrerbildung im Umbruch?}},
  editor       = {{Habig, Sebastian}},
  location     = {{virtuell}},
  pages        = {{605--608}},
  publisher    = {{Universität Duisburg-Essen}},
  title        = {{{ Erweiterung des epistemologischen Verständnisses durch Konfrontation mit anomalen Daten.}}},
  year         = {{2021}},
}

@article{26759,
  abstract     = {{<jats:p>Coatings of modified TiO2 nanoparticles (TiO2-m) have been shown to effectively and selectively trap non-adherent cancer cells, with an enormous potential for applications in photodynamic therapy (PDT). Leukemia cells have a remarkable affinity for TiO2-m coatings, adhering to the surface by membrane structures and exhibiting morphologic characteristics of amoeboid locomotion. However, the details of the cell–substrate interaction induced by the TiO2-m coating remain elusive. With the aim to obtain a better understanding of this phenomenon, leukemia cell adhesion to such coatings was characterized by atomic force microscopy (AFM) for short contact times up to 60 min. The cell and membrane morphological parameters mean cell height, contact area, cell volume, and membrane roughness were determined at different contact times. These results reveal cell expansion and contraction phases occurring during the initial stage of adhesion. Subsequently, the leukemic cells reach what appears to be a new resting state, characterized by pinning of the cell membrane by TiO2-m nanoparticle aggregates protruding from the coating surface.</jats:p>}},
  author       = {{Garcia Diosa, Jaime Andres and Gonzalez Orive, Alejandro and Grundmeier, Guido and Camargo Amado, Ruben Jesus and Keller, Adrian}},
  issn         = {{2076-3417}},
  journal      = {{Applied Sciences}},
  pages        = {{9898}},
  title        = {{{Morphological Dynamics of Leukemia Cells on TiO2 Nanoparticle Coatings Studied by AFM}}},
  doi          = {{10.3390/app11219898}},
  volume       = {{11}},
  year         = {{2021}},
}

@inbook{26874,
  author       = {{Klünder, Nina}},
  booktitle    = {{Wörterbuch. Soziale Arbeit}},
  editor       = {{Amthor, Ralph-Christian and Goldberg, Brigitta and Hansbauer, Peter and Landes, Benjamin and Wintergerst, Theresia}},
  isbn         = {{978-3-7799-3869-9}},
  pages        = {{997--999}},
  publisher    = {{Beltz Juventa}},
  title        = {{{Wörterbuch. Soziale Arbeit}}},
  year         = {{2021}},
}

@article{28789,
  author       = {{Duan, R and Wang, X and Shan, S and Zhao, L and Xiong, J and Libuda, L and Cheng, G}},
  issn         = {{2296-861x}},
  journal      = {{Front Nutr}},
  pages        = {{747088}},
  title        = {{{The Chinese Adolescent Cohort Study: Design, Implementation, and Major Findings.}}},
  doi          = {{10.3389/fnut.2021.747088}},
  volume       = {{8}},
  year         = {{2021}},
}

@article{28879,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
              <jats:title>Purpose</jats:title>
              <jats:p>Studies about effects of lunch dietary Glycemic Index (GI) on cognition of schoolchildren are scarce. Our previous CogniDo GI study found no changes of cognition in the early postprandial phase after consumption of two rice types with medium vs. high dietary GI for lunch (i.e., 45 min after starting lunch). This study investigated whether the dietary GI of lunch has an impact on cognition of schoolchildren in the late postprandial phase, 90 min after lunch.</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Methods</jats:title>
              <jats:p>A randomized, 2 × 2 crossover intervention study was conducted at a comprehensive school with 5th and 6th grade students. Participants (<jats:italic>n</jats:italic> = 212) were randomly assigned to either sequence 1 or 2. In the first period, participants of sequence 1 received a dish with high GI rice (GI: 79), those of sequence 2 with medium GI rice (GI: 64)—in the second period, 1 week later, vice versa. Computer-based cognitive testing was performed 90 min after lunch examining tonic alertness, visual search and task switching, and working memory. Treatment effects and treatment effects adjusted for estimated lunch glycemic load (GL) were analyzed using a linear mixed model.</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Results</jats:title>
              <jats:p>The selected cognitive parameters were not affected by the GI of lunch 90 min after lunch, neither after intention-to-treat nor in the per-protocol analysis. Adjustment for GL also did not change results.</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Conclusion</jats:title>
              <jats:p>The present study revealed no notable differences after the consumption of two rice types with medium vs. high dietary GI for lunch in children’s cognitive function in the late postprandial phase, 90 min after lunch.</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Clinical trial registration</jats:title>
              <jats:p>German Clinical Trials Register (DRKS00013597); date of registration: 16/04/2018, retrospectively registered.</jats:p>
            </jats:sec>}},
  author       = {{Drozdowska, Alina and Sinningen, Kathrin and Falkenstein, Michael and Rudolf, Henrik and Libuda, Lars and Buyken, Anette E. and Lücke, Thomas and Kersting, Mathilde}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  title        = {{{Impact of lunch with carbohydrates differing in glycemic index on children's cognitive functioning in the late postprandial phase: a randomized crossover study}}},
  doi          = {{10.1007/s00394-021-02766-y}},
  year         = {{2021}},
}

@article{26985,
  author       = {{Garcia-Diosa, Jaime Andrés and Orive, Alejandro Gonzalez and Grundmeier, Guido and Keller, Adrian and Camargo-Amado, Rubén Jesús}},
  issn         = {{0257-8972}},
  journal      = {{Surface and Coatings Technology}},
  pages        = {{127823}},
  title        = {{{Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings on cancer cell adhesion}}},
  doi          = {{10.1016/j.surfcoat.2021.127823}},
  year         = {{2021}},
}

@article{27007,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
                <jats:title>Purpose</jats:title>
                <jats:p>To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Methods</jats:title>
                <jats:p>Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Results</jats:title>
                <jats:p>On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.02) and FLI (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.03). On the urinary excretion level, however, a higher FE (P<jats:sub>trend</jats:sub> = 0.03) and FE + SE (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Conclusion</jats:title>
                <jats:p>The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted.</jats:p>
              </jats:sec>}},
  author       = {{Perrar, Ines and Buyken, Anette and Penczynski, Katharina J. and Remer, Thomas and Kuhnle, Gunter G. and Herder, Christian and Roden, Michael and Della Corte, Karen and Nöthlings, Ute and Alexy, Ute}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{3029--3041}},
  title        = {{{Relevance of fructose intake in adolescence for fatty liver indices in young adulthood}}},
  doi          = {{10.1007/s00394-020-02463-2}},
  year         = {{2021}},
}

@article{27014,
  abstract     = {{<jats:p><jats:bold>Purpose:</jats:bold> To examine the prospective relevance of dietary sugar intake (based on dietary data as well as urinary excretion data) in adolescent years for insulin sensitivity and biomarkers of inflammation in young adulthood.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Overall 254 participants of the DONALD study who had at least two 3-day weighed dietary records for calculating intakes of fructose, glucose, sucrose, total, free, added sugars, total sugars from sugar-sweetened beverages (SSB), juice, and sweets/sugar or at least two complete 24 h urine samples (<jats:italic>n</jats:italic> = 221) for calculating sugar excretion (urinary fructose and urinary fructose + sucrose) in adolescence (females: 9–15 years, males: 10–16 years) and a fasting blood sample in adulthood (18–36 years), were included in multivariable linear regression analyses assessing their prospective associations with adult homeostasis model assessment insulin sensitivity (HOMA2-%S) and a pro-inflammatory score (based on CRP, IL-6, IL-18, leptin, chemerin, adiponectin).</jats:p><jats:p><jats:bold>Results:</jats:bold> On the dietary intake level, no prospective associations were observed between adolescent fructose, sucrose, glucose, added, free, total sugar, or total sugar from SSB, juice or sweets/sugar intake and adult HOMA2-%S (<jats:italic>p</jats:italic> &amp;gt; 0.01). On the urinary level, however, higher excreted fructose levels were associated with improved adult HOMA2-%S (<jats:italic>p</jats:italic> = 0.008) among females only. No associations were observed between dietary or urinary sugars and the adult pro-inflammatory score (<jats:italic>p</jats:italic> &amp;gt; 0.01).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> The present study did not provide support that dietary sugar consumed in adolescence is associated with adult insulin sensitivity. The one potential exception was the moderate dietary consumption of fructose, which showed a beneficial association with adult fasting insulin and insulin sensitivity.</jats:p>}},
  author       = {{Della Corte, Karen A. and Penczynski, Katharina and Kuhnle, Gunter and Perrar, Ines and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Remer, Thomas and Alexy, Ute and Buyken, Anette}},
  issn         = {{2296-861X}},
  journal      = {{Frontiers in Nutrition}},
  title        = {{{The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood}}},
  doi          = {{10.3389/fnut.2020.615684}},
  year         = {{2021}},
}

