@article{60606, abstract = {{Streptavidin binding to DNA origami-supported high-density biotin arrays is investigated for selected experimental parameters. While bidentate binding and steric hindrance can be minimized, molecular crowding limits the binding yields in 2D arrays.}}, author = {{Rabbe, Lukas and Tomm, Emilia and Grundmeier, Guido and Keller, Adrian}}, issn = {{2046-2069}}, journal = {{RSC Advances}}, number = {{30}}, pages = {{24536--24543}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Toward high-density streptavidin arrays on DNA origami nanostructures}}}, doi = {{10.1039/d5ra03393d}}, volume = {{15}}, year = {{2025}}, } @phdthesis{60589, author = {{Große-Heilmann, Rike Isabel}}, pages = {{387}}, publisher = {{Logos Verlag Berlin}}, title = {{{Entwicklung fachdidaktischen Wissens zum Einsatz digitaler Medien im Fach Physik}}}, doi = {{https://doi.org/10.30819/5943}}, volume = {{388}}, year = {{2025}}, } @article{60709, abstract = {{Self-assembled DNA origami lattices have promising applications in the fabrication of functional surfaces for sensing and plasmonics via molecular lithography. While surface-assisted DNA origami lattice assembly at mica surfaces is...}}, author = {{Omoboye, Adekunle and Pothineni, Bhanu and Grundmeier, Guido and She, Zhe and Keller, Adrian}}, issn = {{2755-3701}}, journal = {{RSC Applied Interfaces}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Surface potential-dependent assembly of DNA origami lattices at SiO2 surfaces}}}, doi = {{10.1039/d5lf00169b}}, year = {{2025}}, } @inproceedings{60734, author = {{Weiler, David Christoph and Burde, Jan-Philipp and Costan, Kasim and Große-Heilmann, Rike Isabel and Kulgemeyer, Christoph and Lässer, Armin and Riese, Josef and Schubatzky, Thomas }}, booktitle = {{Lernen, lehren und forschen im Schülerlabor}}, location = {{Bochum}}, title = {{{Bedürfnisse von Lehrkräften zu digitalen Medien adressieren! }}}, year = {{2025}}, } @article{60741, author = {{Grimminger-Seidensticker, Elke and Korte, Johanna}}, journal = {{sportunterricht}}, number = {{7}}, pages = {{308--313}}, title = {{{Fitnessbasierte Nutzung sozialer Medien im Jugendalter und im Sportunterricht. Empirische Einblicke in die Jugendkultur und in Perspektiven von Sportlehrkräften}}}, doi = {{10.30426/SU-2025-07-04}}, volume = {{74}}, year = {{2025}}, } @article{36889, author = {{Webersen, Yvonne and Köthemann, Maite}}, journal = {{Naturwissenschaften im Unterricht Physik }}, number = {{207/208}}, pages = {{92--94}}, publisher = {{Friedrich Verlag}}, title = {{{Wie experimentieren eigentlich Physiker:innen? Einblicke in Forschungsprozesse mithilfe von Videointerviews }}}, year = {{2025}}, } @article{60815, abstract = {{AbstractThe increasing demand for advanced sensing technologies drives the development of chemical sensors using innovative materials. In gas sensing, optical sensors are often used to detect gases such as CO, NOx, and O2. Oxygen sensors typically incorporate dyes into oxygen‐permeable matrices like polymers, silica, or zeolites. Alternatively, semiconductor surface chemistry can enable O2 detection. However, these approaches are often limited by slow response and recovery times and low selectivity, restricting their practical applications. The metal‐organic framework MOF‐76(Eu) and its yttrium‐modified variant, MOF‐76(Eu/Y) are reported to exhibit highly reversible and fast optical responses to varying O2 concentrations. Time‐resolved emission measurements are performed over short (seconds) and long (hours) timescales using N2 and synthetic air mixtures. Cross‐sensitivity to humidity is analyzed. Multichannel scaling photon‐counting experiments confirm quenching at the linker level, as the emission lifetime remains nearly constant. Yttrium significantly improves stability and performance at room temperature. Structural and optical changes induced by yttrium are investigated. Additionally, MIL‐78(Eu), another Eu‐BTC‐based MOF with a different coordination environment, is synthesized. Unlike MOF‐76(Eu), MIL‐78(Eu) exhibits distinct optical properties but lacks a reversible response to O2. These results highlight the potential of MOF‐76‐based materials for high‐performance O2 sensing.}}, author = {{Zhao, Zhenyu and Weinberger, Christian and Steube, Jakob and Bauer, Matthias and Brehm, Martin and Tiemann, Michael}}, issn = {{1616-301X}}, journal = {{Advanced Functional Materials}}, publisher = {{Wiley}}, title = {{{Fast‐Responding O2 Gas Sensor Based on Luminescent Europium Metal‐Organic Frameworks (MOF‐76)}}}, doi = {{10.1002/adfm.202511190}}, year = {{2025}}, } @article{60873, abstract = {{Abstract Variations in circadian rhythm-related genes influence the individual chronotype. Here, we hypothesize that the peak of clock gene expression at 7 a.m. differs between young adults with a late chronotype and young adults with an early chronotype. Participants of the Chronotype and Nutrition nutritional trial (ChroNu study) were selected for their chronotype assessed by the Munich Chronotype questionnaire (MCTQ) and actigraphy. Total RNA was isolated from CD14+ monocytes of participants at 7 a.m. on the run-in day. Expression levels of seven clock genes (PER1, PER2, PER3, NR1D1, NR1D2, CRY1 and CRISPLD2) of individuals with early (n = 11) or late chronotypes (n = 19) were analysed by reverse transcription quantitative polymerase chain reaction. Difference in expression levels was tested by Mann Whitney-U test. The relative expression levels of the selected genes were not significantly different between individuals with early and late chronotypes (all p > 0.07). Contrary to expectation, clock gene expression levels at 7 a.m. was similar in individuals with early and late chronotypes. Further studies on larger sample sizes with multiple sampling time points should elucidate whether gene expression is altered at other day times underscoring the biological difference between individuals with early or late chronotypes.}}, author = {{Krueger, Bettina and Rajcsanyi, Luisa Sophie and Hundertmark, Katharina and Stutz, Bianca and Hinney, Anke and Buyken, Anette E.}}, issn = {{2045-2322}}, journal = {{Scientific Reports}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Morning clock gene expression in young adults of early and late chronotypes}}}, doi = {{10.1038/s41598-025-12423-7}}, volume = {{15}}, year = {{2025}}, } @inproceedings{57760, author = {{Hörnlein, Madeleine and Riese, Josef and Kulgemeyer, Christoph}}, booktitle = {{Lernen, Lehren und Forschen im Schülerlabor. Jahrestagung der Gesellschaft für Didaktik der Chemie und Physik 2024}}, editor = {{van Vorst, Helena}}, location = {{Bochum }}, title = {{{"Ich glaub, ich hab's verstanden." - Verstehensillusion bei Erklärvideos}}}, year = {{2025}}, } @article{60862, author = {{Grotevent, Matthias J. and Kothe, Linda and Lu, Yongli and Krajewska, Chantalle J. and Shih, Meng-Chen and Tan, Shaun and Tiemann, Michael and Bawendi, Moungi G.}}, issn = {{0897-4756}}, journal = {{Chemistry of Materials}}, number = {{15}}, pages = {{5866–5873}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Nontoxic and Rapid Chemical Bath Deposition for SnO2 Electron Transporting Layers in Perovskite Solar Cells}}}, doi = {{10.1021/acs.chemmater.5c01081}}, volume = {{37}}, year = {{2025}}, } @article{60600, abstract = {{In the search for noble metal free photocatalytic systems, iron is the dream candidate. To increase excited state lifetimes of iron complexes, the multichromophoric approach is promising, combining organic chromophores with photoactive iron complexes, potentially enabling a reservoir effect. We present a series of chromophore-functionalized complexes based on the parental FeIII complex [Fe(ImP)2][PF6] (HImP = 1,1′-(1,3-phenylene)bis(3-methyl-1-imidazole-2-ylidene)). The four organic chromophores benzene, naphthalene, anthracene, and pyrene are attached to the ImP-ligand in para-position to the coordination site to systematically investigate the influence of the steric demand and electronic properties of the chromophore on charge transfer lifetimes as well as photodynamics. A thorough ground state characterization was conducted in addition to investigations of the excited state dynamics by transient absorption spectroscopy and streak camera emission measurements. The conclusions drawn are supported by extensive DFT calculations. The emission coefficients could be significantly improved by the addition of chromophores. After excitation of the complexes with larger chromophores, coplanarization of the backbone and complex motif occurs to stabilize the formal charge. This results in population of a superligand state that exhibits a much faster radiationless relaxation to the ground state compared to the parent complex, hindering a reservoir effect.}}, author = {{Schmitz, Lennart and Argüello Cordero, Miguel A. and Al-Marri, Mohammed J. and Schoch, Roland and Egold, Hans and Neuba, Adam and Steube, Jakob and Bracht, Bastian Johannes and Bokareva, Olga S. and Lochbrunner, Stefan and Bauer, Matthias}}, issn = {{0020-1669}}, journal = {{Inorganic Chemistry}}, keywords = {{Photo}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Chromophore Induced Effects in Iron(III) Complexes}}}, doi = {{10.1021/acs.inorgchem.5c00526}}, year = {{2025}}, } @article{58180, abstract = {{A series of CoIII complexes [Co(RImP)2][PF6], with HMeImP = 1,1′-(1,3-phenylene)bis(3-methyl-1-imidazole-2-ylidene)) and R = Me, Et, iPr, nBu, is presented in this work. The influence of the strong donor ligand on the ground and excited-state photophysical properties was investigated in the context of different alkyl substituents at the imidazole nitrogen. X-ray diffraction revealed no significant alterations of the structures and all differences in the series emerge from the electronic structures. These were probed via cyclic voltammetry and UV–vis spectroscopy, detailing the influence of the different alkyl substituents on the ground-state properties. All complexes are emissive at 77 K from a 3MC state, which exhibits lifetimes in the range of 1–5 ns at room temperature, depending on the alkyl substituent. Therefore, it is clearly shown that even small differences in the electronic structure have a large impact on the details of the excited state landscape. The observed behavior was rationalized by a detailed DFT analysis, which shows that the minimum-energy crossing point to the ground-state is located only slightly above the MC energy: Consequently, nonradiative decay to the ground state at room temperature is enabled, while at 77 K this path is prohibited, leading to low-temperature 3MC emission.}}, author = {{Krishna, Athul and Fritsch, Lorena and Steube, Jakob and Argüello Cordero, Miguel A. and Schoch, Roland and Neuba, Adam and Lochbrunner, Stefan and Bauer, Matthias}}, issn = {{0020-1669}}, journal = {{Inorganic Chemistry}}, keywords = {{Photo}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Low Temperature Emissive Cyclometalated Cobalt(III) Complexes}}}, doi = {{10.1021/acs.inorgchem.4c04479}}, year = {{2025}}, } @article{60973, abstract = {{The specific binding of DNA origami nanostructures (DONs) to bacteria is an important prerequisite for their application in pathogen targeting and antimicrobial drug delivery. So far, targeting bacteria with DONs has been achieved exclusively via aptamers, which suffer from drawbacks such as sensitivity toward environmental conditions and reduced binding after immobilization or conjugation. Here, an alternative approach is presented based on the modification of DONs with the cell wall‐binding glycopeptide antibiotic vancomycin. Using strain‐promoted azide‐alkyne cycloaddition, azide‐modified vancomycin is conjugated to selected staple strands and subsequently incorporated into 2D DON triangles. The resulting constructs show specific binding to the Gram‐positive species Bacillus subtilis (B. subtilis) and Staphylococcus capitis (S. capitis), and remarkably, to Gram‐negative Escherichia coli (E. coli), but no antimicrobial activity at vancomycin concentrations up to at least 2.91 μM. For B. subtilis and E. coli, DONs with vancomycin modifications on both sides exhibit better binding than DONs modified on only one side. However, both variants bind equally well to S. capitis. These results demonstrate the great potential of small molecule drug compounds for the robust, broad‐spectrum targeting of bacteria with DONs. Targeting a ubiquitous cell wall component of most pathogenic bacteria, vancomycin‐modified DONs have many potential applications in the prevention and treatment of nosocomial infections.}}, author = {{Coşkuner Leineweber, Özge and Pothineni, Bhanu K. and Schumann, Nils and Hofmann, Ulrike and Möser, Christin and Smith, David M. and Grundmeier, Guido and Zhang, Yixin and Keller, Adrian}}, issn = {{2688-4062}}, journal = {{Small Structures}}, publisher = {{Wiley}}, title = {{{Vancomycin‐Modified DNA Origami Nanostructures for Targeting Bacterial Pathogens}}}, doi = {{10.1002/sstr.202500246}}, year = {{2025}}, } @article{61003, author = {{Hasija, Tanuj and Kuschel, Maurice and Jackson, Michele and Dailey, Stephanie and Menne, Henric and Reinsberger, Claus and Vieluf, Solveig and Loddenkemper, Tobias}}, issn = {{0933-3657}}, journal = {{Artificial Intelligence in Medicine}}, publisher = {{Elsevier BV}}, title = {{{Improving wearable-based seizure prediction by feature fusion using an explainable growing network}}}, doi = {{10.1016/j.artmed.2025.103228}}, volume = {{169}}, year = {{2025}}, } @article{60996, abstract = {{Abstract The benefits of physical activity are undisputed. However, adverse events can occur in rare cases, particularly during high-intensity or prolonged exercise. During physical activity, at-risk patients can experience major cardiac events, whereas adverse events affecting the musculoskeletal system are more common but less severe. A sports preparticipation evaluation (PPE) for apparently healthy adults is designed to detect at-risk individuals and prevent potentially fatal events. This guideline for conducting PPEs was developed by consensus among 16 medical societies and sports associations and is based on previously published guidelines and consensus papers. Sports medicine physicians and potential participants were also surveyed to assess the recommendations’ content, feasibility, and implementation. On the basis of the 20 recommendations developed and agreed upon by the abovementioned entities, PPE comprises individuals’ personal, family, and sports histories, as well as a physical examination. The need for additional examinations (e.g., laboratory parameters, echocardiograms, or stress tests) is determined on the basis of the PPE findings. This approach’s feasibility in various regions, including resource-limited settings, and the extent to which it prevents adverse or potentially fatal events, should be examined in future research.}}, author = {{Joisten, Christine and Hirschmüller, Anja and Bauer, Pascal and Baum, Erika and Behrens, Meinolf and Berrisch-Rahmel, Susanne and Berrsche, Gregor and Carlsohn, Anja and Cassel, Michael and DeZeuuw, Justus and Dörr, Gesine and Dreher, Michael and Edelmann, Frank and Esefeld, Katrin and Freitag, Michael and Grebe, Mathias and Grim, Casper and Janßen, Pia and Kaiser, Rolf and Katlun, Thomas and Köppel, Maximilian and Kreutz, Charlotte and Krüger, Karsten and Lutter, Christoph and Mayer, Frank and Moser, Othmar and Nieß, Andreas and Predel, Hans-Georg and Peters, Stefan and Platen, Petra and Portius, Dorothea and Reinsberger, Claus and Reiss, Nils and Röcker, Kai and Schmidt, Thomas and Schmidt-Trucksäss, Arno and Schmitt, Holger and Schramm, Thomas and Sturm, Christian and Vater, Hans and Weise, Alina and Weisser, Burkhard and Welsch, Götz and Winkelmann, Andreas and Wirth, Alfred and Wolfarth, Bernd and Goossen, Käthe}}, issn = {{0112-1642}}, journal = {{Sports Medicine}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Sports Preparticipation Evaluation for Healthy Adults: A Consensus-Based German Guideline}}}, doi = {{10.1007/s40279-025-02230-5}}, year = {{2025}}, } @article{61015, author = {{Baier, Dominik and Kieke, Laureen and Voth, Sven and Kloß, Marvin and Huck, Marten and Steinrück, Hans-Georg and Tiemann, Michael}}, issn = {{2379-3694}}, journal = {{ACS Sensors}}, number = {{8}}, pages = {{5664--5673}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Selective H2 Gas Sensing Using ZIF-71/In-SnO2 Bilayer Sensors: A Size-Selective Molecular Sieving Approach}}}, doi = {{10.1021/acssensors.5c00770}}, volume = {{10}}, year = {{2025}}, } @article{61006, abstract = {{ Objective This cross-sectional study aimed to investigate subjective and objective deficits of neurocognitive function, balance and vestibulo-ocular performance in athletes with sport-related concussion (SRC) compared with healthy control athletes. Methods 72 patients with SRC and 72 matched healthy controls were included. All participants performed computerised testing of neurocognitive function, device-assisted balance testing and objective evaluation of vestibulo-ocular function (video head impulse and dynamic visual acuity test). Clinical symptom clusters (headache/migraine, anxiety/mood, fatigue, cognitive, vestibular, ocular) were determined for each patient using the Sport Concussion Assessment Tool, 5th edition symptom evaluation. Independent t-tests or Mann-Whitney U tests were calculated to test for group differences in the whole cohort and according to clinical symptom clusters. Results When investigating the whole cohort, significant differences between patients with SRC and control subjects were found in one parameter of balance testing (sway velocity double-firm), with lower performance in the SRC group (p<0.001, r=0.345). The number of symptom clusters assigned to the SRC patients ranged from 0 (no definite cluster) to 6 (all clusters), and all clusters were frequent in the investigated cohort. Patients with vestibular, cognitive and fatigue symptom clusters demonstrated significantly lower performance in balance testing compared with SRC patients without those clusters (p<0.001 to p=0.005, r=0.368–0.439). Additionally, SRC patients presenting with symptoms of the fatigue cluster demonstrated significantly worse performance in vestibulo-ocular testing compared with SRC patients without the fatigue cluster (p=0.006, d=0.781). Conclusion SRC patients presented with variable numbers and qualities of clinical symptom clusters. Some subjective clusters were associated with abnormal objective tests of other clusters (vestibular, cognitive and fatigue with abnormal balance; and fatigue with abnormal vestibulo-ocular performance). Clinical symptom clusters and their overlap should be considered when examining patients with SRC. }}, author = {{Weike, Lea and Reeschke, Rebecca and Reinsberger, Claus}}, issn = {{2055-7647}}, journal = {{BMJ Open Sport & Exercise Medicine}}, number = {{3}}, publisher = {{BMJ}}, title = {{{Clinical symptom clusters, neurocognitive function, balance and vestibulo-ocular function in athletes with sport-related concussion}}}, doi = {{10.1136/bmjsem-2024-002447}}, volume = {{11}}, year = {{2025}}, } @article{61000, author = {{van den Bongard, Franziska and Petersen, Catharina and Reinsberger, Claus}}, issn = {{2589-9864}}, journal = {{Epilepsy & Behavior Reports}}, publisher = {{Elsevier BV}}, title = {{{Safety and feasibility of exhaustive exercise testing for people with epilepsy}}}, doi = {{10.1016/j.ebr.2025.100762}}, volume = {{30}}, year = {{2025}}, } @article{61007, abstract = {{ABSTRACT Purpose Repetitive head impacts due to heading in soccer may bear the potential to induce brain changes. To investigate how brain development is affected by heading, effects of heading exposure on neurocognitive and vestibular performance in adolescent soccer players were prospectively examined. Methods In this longitudinal cohort study, male and female high-level youth soccer players of different ages were enrolled in two seasons. Age-matched athletes of other ball sports were included as controls. Before and after each season, neurocognitive performance (6 domain scores), vestibulo-ocular reflex, dynamic visual acuity, and postural control (sway velocity) were objectively assessed in all athletes. Every soccer training and match during the observation period was videotaped to analyze individual heading exposure. Associations between heading frequency (total, in duels, >20 m flight distance) and pre- to post-changes were investigated via Spearman correlation. Results 103 soccer and 51 control athletes (9-19 years) participated. Neurocognitive scores and sway velocity significantly improved in each season in soccer and control athletes. There were no associations between total heading numbers and changes in any parameter. Over the first season, the more headers played in duels (r = -0.255, 95%CI = -0.474 to -0.006, p = 0.04) and from >20 m distance (r = -0.299, 95%CI = -0.510 to -0.055, p = 0.02) the less psychomotor speed improvement occurred. In the second season, improvements in reaction time were significantly smaller with higher numbers of headers played in duels (r = 0.375, 95%CI = 0.043 to 0.632, p = 0.02) and from >20 m distance (r = 0.359, 95%CI = 0.025 to 0.621, p = 0.03). Conclusions Potential high-impact headers may have affected neurocognitive improvements, exhibiting small to moderate effects. Therefore, more high-impact headers may be more important to consider than solely the overall heading exposure in discussions about adverse effects in youth soccer. }}, author = {{Reeschke, Rebecca and Dautzenberg, Lena and Mund, Franziska Katharina and Koch, Thorsten and Reinsberger, Claus}}, issn = {{1530-0315}}, journal = {{Medicine & Science in Sports & Exercise}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Effects of Different Header Types on Neurocognitive and Vestibular Performance in Youth Soccer Players}}}, doi = {{10.1249/mss.0000000000003831}}, year = {{2025}}, } @article{60719, abstract = {{Abstract Background Parkinson’s Disease (PD) bears a variety of sex differences and is associated with cardiovascular dysregulation (CDR). Variation in the routinely assessed standard parameters heart rate (HR) and blood pressure (BP) seem not well understood within the frame of sex-specific developments under therapy. Parameters of heart rate variability (RMSSD) and electrodermal activity (meanEDA) may assist the understanding of underlying autonomic developments. This pilot study aims to describe sex-specific cardiovascular and autonomic responses to a multimodal inpatient rehabilitation program in patients with PD. Methods Forty-one PD patients (24 male, 17 female) participated in a stationary, multimodal therapy intervention (MTI). Before and after MTI, HR, BP, RMSSD, and meanEDA were assessed in supine baseline (5 min of rest before orthostasis) and during supine adaption to rest (5 min of rest after orthostasis). Differences between baseline and adaption to rest as well as differences over time of MTI were calculated using Wilcoxon test; sex differences using Mann–Whitney-U test. Results Before MTI, women’s supine HR (p = .034*; d = .17) and BP (p = .015*, d = 0.4) were significantly higher during adaption to rest than during baseline. After MTI, women’s supine HR (p = .020*; d = .84) and BP (p = .022*, d = 0.5) during adaption to rest had decreased significantly. Men’s HR and BP remained constant and without differences between the supine conditions. RMSSD and meanEDA remained steady in both sexes. Conclusion The sex-specific responsiveness to MTI supports the concept of sex-sensitive therapeutic management for cardiovascular symptoms in PD. In both sexes, peripheral cardiovascular outcomes appeared not attributable to corresponding outcomes in autonomic regulation. Further examination of autonomic parameters could provide a foundation for developing therapeutic approaches that address central nervous system mechanisms. The study was officially registered (08/2020). The data supporting the findings of this study are available under http://apps.who.int/trialsearch/ under trial number DRKS00022773. }}, author = {{Siche-Pantel, Franziska and Mühlenberg, Manfred and Buschfort, Rüdiger and Michels, Heinke and Jakobsmeyer, Rasmus and Oesterschlink, Julian and Reinsberger, Claus}}, issn = {{1471-2377}}, journal = {{BMC Neurology}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study}}}, doi = {{10.1186/s12883-025-04281-7}}, volume = {{25}}, year = {{2025}}, }