@article{64887, abstract = {{Abstract Lachgas gelangt etwa aus Düngemitteln, Abgasen oder Narkosemitteln in die Atmosphäre und verursacht rund sechs Prozent der globalen Erwärmung. Effiziente Methoden, Lachgas abzubauen, gibt es bisher nicht. Wie ein neuer metallfreier Katalysator helfen könnte.}}, author = {{Paradies, Jan}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{1}}, pages = {{61--63}}, publisher = {{Wiley}}, title = {{{Nichts zu lachen – oder doch?}}}, doi = {{10.1002/nadc.20264154740}}, volume = {{74}}, year = {{2026}}, } @article{64886, abstract = {{ In the young field of enantioselective catalysis by frustrated Lewis pairs, the search for new chiral backbones for Lewis acids is desirable for future developments of the field. By taking advantage of the toluenesulfinyl group, a very useful traceless chiral auxiliary, it was possible to decorate stereopure axially chiral biphenyl tolyl sulfoxides and access unique chiral quaterphenyl tolyl sulfoxides by directed ortho ‐metalation and electrophile trapping as well as a dynamic kinetic asymmetric arylative cross‐coupling. The resulting chiral backbone is amenable to accessing chiral boron‐based Lewis acids by conversion of the sulfinyl group to boron‐based ones. }}, author = {{Berreur, Jordan and Bortoluzzi, Julien and Köring, Laura and Leroux, Frédéric R. and Paradies, Jan and Panossian, Armen}}, issn = {{1434-1948}}, journal = {{European Journal of Inorganic Chemistry}}, publisher = {{Wiley}}, title = {{{Double Functionalization of Atropisomeric Biphenyl Sulfoxides by Ortho ‐Metalation and DYKAT Toward Chiral Quaterphenyl‐Based Borane Lewis Acids}}}, doi = {{10.1002/ejic.70158}}, year = {{2026}}, } @article{61335, abstract = {{Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus, efficient strategies for their preparation are in great demand. Herein, a novel protocol is reported for the synthesis of amidines based on PIII/PVO redox catalysis. This two‐step, one‐pot approach involves the activation of amides via PIII/PVO catalyzed in situ formation of imidoyl chloride intermediates which are directly converted upon reaction with amines into the corresponding amidines. Instead of traditionally used toxic and corrosive chloride sources, hexachloroacetone (HCA) is successfully employed as a halide source. The reaction proceeds with low catalyst loading (2 mol%) in BuOAc as the solvent. Under the optimized conditions, 20 amidines are prepared in yields up to 99%. A feasible mechanism is proposed based on experimental results. The synthetic potential of this method is evaluated in the preparation of the tyrosine kinase inhibitor (TKI) Erlotinib.}}, author = {{Medvaric, Viktorija and Paradies, Jan and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T2, T, CSSD}}, publisher = {{Wiley}}, title = {{{Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides}}}, doi = {{10.1002/adsc.70059}}, year = {{2025}}, } @article{61336, author = {{Zhou, Rundong and Medvaric, Viktorija and Werner, Thomas and Paradies, Jan}}, issn = {{0002-7863}}, journal = {{Journal of the American Chemical Society}}, keywords = {{T2, CSSD}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Metal-Free Reduction of Nitrous Oxide via PIII/PV═O Cycling: Mechanistic Insights and Catalytic Performance}}}, doi = {{10.1021/jacs.5c06190}}, year = {{2025}}, } @article{52541, abstract = {{AbstractWe conducted an investigation into the palladium‐catalyzed carbon‐sulfur cross‐coupling reaction involving a 2‐bromothiophene derivative and potassium thioacetate as a substitute for hydrogen sulfide. This investigation utilized kinetic and computational methods. We synthesized two palladium complexes supported by the bisphosphane ligands bis(diphenylphosphino)ferrocene (DPPF) and bis(diisopropylphosphino)ferrocene (DiPPF), as well as their tentative intermediates in the catalytic cycle. Reaction rates were measured and then compared to computational predictions.}}, author = {{Peschtrich, Sebastian and Schoch, Roland and Kuckling, Dirk and Paradies, Jan}}, issn = {{1434-193X}}, journal = {{European Journal of Organic Chemistry}}, keywords = {{Organic Chemistry, Physical and Theoretical Chemistry}}, number = {{8}}, publisher = {{Wiley}}, title = {{{A Comparative Kinetic and Computational Investigation of the Carbon‐Sulfur Cross Coupling of Potassium Thioacetate and 2‐Bromo Thiophene Using Palladium/Bisphosphine Complexes}}}, doi = {{10.1002/ejoc.202301207}}, volume = {{27}}, year = {{2024}}, } @article{52572, abstract = {{A series of substituted ferrocenyl boron derivatives was synthesized. The oxidation of the ferrocenyl unit resulted in a significant increase of the boron‐centered Lewis acidity. The neutral and cationic Lewis acids were characterized by NMR‐spectroscopy, crystal structure analysis and by computational methods. The new Lewis acids were then applied in the Meinwald rearrangement of epoxides, predominantly furnishing aldehydes as the kinetic products.}}, author = {{Köring, Laura and Birenheide, Bernhard and Krämer, Felix and Wenzel, Jonas O. and Schoch, Roland and Brehm, Martin and Breher, Frank and Paradies, Jan}}, issn = {{1434-1948}}, journal = {{European Journal of Inorganic Chemistry}}, keywords = {{Inorganic Chemistry}}, publisher = {{Wiley}}, title = {{{Synthesis of Ferrocenyl Boranes and their Application as Lewis Acids in Epoxide Rearrangements}}}, doi = {{10.1002/ejic.202400057}}, year = {{2024}}, } @article{55371, abstract = {{AbstractThe activation of C(sp3)−F bonds by the commercially available catalyst B(C6F5)3 is reported and applied in reactions with arenes, allylic, vinylic and acetylenic silanes, and olefins to achieve a variety of C−C bond formations (45 examples).}}, author = {{Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, number = {{13}}, pages = {{2933--2938}}, publisher = {{Wiley}}, title = {{{Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds}}}, doi = {{10.1002/adsc.202400511}}, volume = {{366}}, year = {{2024}}, } @article{59616, abstract = {{AbstractThe activation of C(sp3)−F bonds by the commercially available catalyst B(C6F5)3 is reported and applied in reactions with arenes, allylic, vinylic and acetylenic silanes, and olefins to achieve a variety of C−C bond formations (45 examples).}}, author = {{Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{fluoride, bond activation, borane, Lewis acid, C-C bond formation}}, number = {{13}}, pages = {{2933--2938}}, publisher = {{Wiley}}, title = {{{Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds}}}, doi = {{10.1002/adsc.202400511}}, volume = {{366}}, year = {{2024}}, } @article{47589, author = {{Krämer, Felix and Paradies, Jan and Fernández, Israel and Breher, Frank}}, issn = {{1755-4330}}, journal = {{Nature Chemistry}}, keywords = {{General Chemical Engineering, General Chemistry}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{A crystalline aluminium–carbon-based ambiphile capable of activation and catalytic transfer of ammonia in non-aqueous media}}}, doi = {{10.1038/s41557-023-01340-9}}, year = {{2023}}, } @article{52542, abstract = {{AbstractWe report on so‐called “hidden FLPs” (FLP: frustrated Lewis pair) consisting of a phosphorus ylide featuring a group 13 fragment in the ortho position of a phenyl ring scaffold to form five‐membered ring structures. Although the formation of the Lewis acid/base adducts was observed in the solid state, most of the title compounds readily react with carbon dioxide to provide stable insertion products. Strikingly, 0.3–3.0 mol% of the reported aluminum and gallium/carbon‐based ambiphiles catalyze the reduction of CO2 to methanol with satisfactory high selectivity and yields using pinacol borane as stoichiometric reduction equivalent. Comprehensive computational studies provided valuable mechanistic insights and shed more light on activity differences.}}, author = {{Krämer, Felix and Paradies, Jan and Fernández, Israel and Breher, Frank}}, issn = {{0947-6539}}, journal = {{Chemistry – A European Journal}}, keywords = {{General Chemistry, Catalysis, Organic Chemistry}}, number = {{5}}, publisher = {{Wiley}}, title = {{{Quo Vadis CO2 Activation: Catalytic Reduction of CO2 to Methanol Using Aluminum and Gallium/Carbon‐based Ambiphiles}}}, doi = {{10.1002/chem.202303380}}, volume = {{30}}, year = {{2023}}, } @article{42878, author = {{Köring, Laura and Stepen, Arne and Birenheide, Bernhard and Barth, Simon and Leskov, Maxim and Schoch, Roland and Krämer, Felix and Breher, Frank and Paradies, Jan}}, issn = {{1433-7851}}, journal = {{Angewandte Chemie International Edition}}, keywords = {{General Chemistry, Catalysis}}, publisher = {{Wiley}}, title = {{{Boron‐Centered Lewis Superacid through Redox‐Active Ligands: Application in C−F and S−F Bond Activation}}}, doi = {{10.1002/anie.202301632}}, year = {{2023}}, } @article{42879, author = {{Köring, Laura and Stepen, Arne and Birenheide, Bernhard and Barth, Simon and Leskov, Maxim and Schoch, Roland and Krämer, Felix and Breher, Frank and Paradies, Jan}}, issn = {{0044-8249}}, journal = {{Angewandte Chemie}}, keywords = {{General Medicine}}, publisher = {{Wiley}}, title = {{{Boron‐Centered Lewis Superacid through Redox‐Active Ligands: Application in C−F and S−F Bond Activation}}}, doi = {{10.1002/ange.202301632}}, year = {{2023}}, } @article{44523, author = {{Paradies, Jan}}, issn = {{0001-4842}}, journal = {{Accounts of Chemical Research}}, keywords = {{General Medicine, General Chemistry}}, number = {{7}}, pages = {{821--834}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Structure–Reactivity Relationships in Borane-Based FLP-Catalyzed Hydrogenations, Dehydrogenations, and Cycloisomerizations}}}, doi = {{10.1021/acs.accounts.2c00832}}, volume = {{56}}, year = {{2023}}, } @article{46277, author = {{Sieland, Benedikt and Stahn, Marcel and Schoch, Roland and Daniliuc, Constantin and Spicher, Sebastian and Grimme, Stefan and Hansen, Andreas and Paradies, Jan}}, issn = {{1433-7851}}, journal = {{Angewandte Chemie International Edition}}, keywords = {{General Chemistry, Catalysis}}, publisher = {{Wiley}}, title = {{{Dispersion Energy‐Stabilized Boron and Phosphorus Lewis Pairs}}}, doi = {{10.1002/anie.202308752}}, year = {{2023}}, } @article{64893, abstract = {{AbstractThe synthesis of three novel imidazolyl‐substituted sulfur‐containing heteroacenes is reported. These heteroacenes consisting of annelated benzo‐ and naphthothiophenes serve as precursors for the generation of open‐shell quinoid heteroacenes by oxidation with alkaline ferric cyanide. Spectroscopic and computational experiments support the formation of reactive open‐shell quinoids, which, however, quickly produce paramagnetic polymeric material.}}, author = {{Hou, Peng and Peschtrich, Sebastian and Feuerstein, Wolfram and Schoch, Roland and Hohloch, Stephan and Breher, Frank and Paradies, Jan}}, issn = {{2191-1363}}, journal = {{ChemistryOpen}}, number = {{11}}, publisher = {{Wiley}}, title = {{{Imidazolyl‐Substituted Benzo‐ and Naphthodithiophenes as Precursors for the Synthesis of Transient Open‐Shell Quinoids}}}, doi = {{10.1002/open.202300003}}, volume = {{12}}, year = {{2023}}, } @article{35703, author = {{Hou, Peng and Peschtrich, Sebastian and Huber, Nils and Feuerstein, Wolfram and Bihlmeier, Angela and Krummenacher, Ivo and Schoch, Roland and Klopper, Wim and Breher, Frank and Paradies, Jan}}, issn = {{0947-6539}}, journal = {{Chemistry – A European Journal}}, keywords = {{General Chemistry, Catalysis, Organic Chemistry}}, number = {{23}}, publisher = {{Wiley}}, title = {{{Cover Feature: Impact of Heterocycle Annulation on NIR Absorbance in Quinoid Thioacene Derivatives (Chem. Eur. J. 23/2022)}}}, doi = {{10.1002/chem.202200982}}, volume = {{28}}, year = {{2022}}, } @article{59619, abstract = {{AbstractA frustrated Lewis pair‐catalyzed hydroboration of aromatic and aliphatic nitriles was developed. The catalyst provides the primary amines in high yields of 77–99% with catalyst loading as low as 2 mol%. The reaction displays high functional group tolerance towards esters, amides, nitro groups and aliphatic halides. The addition of the diborylated amines to ethyl 3‐phenylpropiolate proceeds with Z‐selectivity with d.r. of >99:1 in 77–90% yield over two steps. The reaction mechanism was investigated by control and computational experiments.magnified image }}, author = {{Sieland, Benedikt and Hoppe, Axel and Stepen, Arne J. and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{hydroboration, nitrile, amine, frustrated Lewis pair, density functional theory}}, number = {{18}}, pages = {{3143--3148}}, publisher = {{Wiley}}, title = {{{Frustrated Lewis Pair‐Catalyzed Hydroboration of Nitriles: FLP Versus Borenium Catalysis}}}, doi = {{10.1002/adsc.202200525}}, volume = {{364}}, year = {{2022}}, } @article{64895, abstract = {{AbstractElektrochemische Synthese – Naturstoffe und deren Synthese – photokatalytische Redoxchemie – Farbstoffe – Nanostrukturen – Wirkstoffe – asymmetrische Katalyse und mehr.}}, author = {{Paradies, Jan and Andexer, Jennifer and Beifuss, Uwe and Beuerle, Florian and Brasholz, Malte and Breinbauer, Rolf and Ernst, Martin and Ganardi, Ruth and Gulder, Tobias A. M. and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Körber, Karsten and Kordes, Markus and Lehmann, Matthias and Lindel, Thomas and Luy, Burkhard and Mück‐Lichtenfeld, Christian and Muhle‐Goll, Claudia and Niemeyer, Jochen and Pfau, Roland and Pietruszka, Jörg and Röckl, Johannes L. and Schaschke, Norbert and Senge, Mathias O. and Straub, Bernd F. and Waldvogel, Siegfried R. and Werner, Thomas and Werz, Daniel B. and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{38--68}}, publisher = {{Wiley}}, title = {{{Organische Chemie}}}, doi = {{10.1002/nadc.20214105947}}, volume = {{69}}, year = {{2021}}, } @article{37956, author = {{Andexer, Jennifer N. and Beifuss, Uwe and Beuerle, Florian and Brasholz, Malte and Breinbauer, Rolf and Ernst, Martin and Greb, Julian and Gulder, Tobias and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Kordes, Markus and Lehmann, Matthias and Lindel, Thomas and Luy, Burkhard and Mück‐Lichtenfeld, Christian and Muhle, Claudia and Narine, Arun and Niemeyer, Jörg and Paradies, Jan and Pfau, Roland and Pietruszka, Jörg and Schaschke, Norbert and Senge, Mathias and Straub, Bernd F. and Werner, Thomas and Werz, Daniel B. and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, keywords = {{General Chemical Engineering, General Chemistry}}, number = {{3}}, pages = {{42--72}}, publisher = {{Wiley}}, title = {{{Organische Chemie}}}, doi = {{10.1002/nadc.20204095515}}, volume = {{68}}, year = {{2020}}, } @article{64896, abstract = {{AbstractLichtinduzierte Prozesse effizient nutzen – Catenane und neue Kohlenstoffallotrope – komplexe Naturstoffe, einfache Wirkstoffe – Enzyme, Proteine und mehr, zusammengestellt von 26 Autoren, koordiniert von Jan Paradies.}}, author = {{Andexer, Jennifer N. and Beifuss, Uwe and Beuerle, Florian and Brasholz, Malte and Breinbauer, Rolf and Ernst, Martin and Greb, Julian and Gulder, Tobias and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Kordes, Markus and Lehmann, Matthias and Lindel, Thomas and Luy, Burkhard and Mück‐Lichtenfeld, Christian and Muhle, Claudia and Narine, Arun and Niemeyer, Jörg and Paradies, Jan and Pfau, Roland and Pietruszka, Jörg and Schaschke, Norbert and Senge, Mathias and Straub, Bernd F. and Werner, Thomas and Werz, Daniel B. and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, number = {{3}}, pages = {{42--72}}, publisher = {{Wiley}}, title = {{{Organische Chemie}}}, doi = {{10.1002/nadc.20204095515}}, volume = {{68}}, year = {{2020}}, }