@article{27026,
  abstract     = {{<jats:p>While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To estimate the role of lowered 25(OH)vitamin D concentrations in the etiology of depressive disorders, we conducted a two-sample Mendelian randomization (MR) study on depression, i.e., “depressive symptoms” (DS, n = 161,460) and “broad depression” (BD, n = 113,769 cases and 208,811 controls). Six single nucleotide polymorphisms (SNPs), which were genome-wide significantly associated with 25(OH)vitamin D concentrations in 79,366 subjects from the SUNLIGHT genome-wide association study (GWAS), were used as an instrumental variable. None of the six SNPs was associated with DS or BD (all p &gt; 0.05). MR analysis revealed no causal effects of 25(OH)vitamin D concentration, either on DS (inverse variance weighted (IVW); b = 0.025, SE = 0.038, p = 0.52) or on BD (IVW; b = 0.020, SE = 0.012, p = 0.10). Sensitivity analyses confirmed that 25(OH)vitamin D concentrations were not significantly associated with DS or BD. The findings from this MR study indicate no causal relationship between vitamin D concentrations and depressive symptoms, or broad depression. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation.</jats:p>}},
  author       = {{Libuda, Lars and Laabs, Björn-Hergen and Ludwig, Christine and Bühlmeier, Judith and Antel, Jochen and Hinney, Anke and Naaresh, Roaa and Föcker, Manuel and Hebebrand, Johannes and König, Inke R. and Peters, Triinu}},
  issn         = {{2072-6643}},
  journal      = {{Nutrients}},
  title        = {{{Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study}}},
  doi          = {{10.3390/nu11051085}},
  year         = {{2019}},
}

@article{27025,
  author       = {{Knoll-Pientka, Nadja and Bühlmeier, Judith and Peters, Triinu and Albrecht, Muriel and Adams, Frederike and Wustrau, Katharina and Teufel, Martin and Hebebrand, Johannes and Föcker, Manuel and Libuda, Lars}},
  issn         = {{1590-1262}},
  journal      = {{Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity}},
  pages        = {{911--919}},
  title        = {{{Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study}}},
  doi          = {{10.1007/s40519-019-00705-9}},
  year         = {{2019}},
}

@article{27521,
  author       = {{Hebebrand, Johannes and Milos, Gabriella and Wabitsch, Martin and Teufel, Martin and Führer, Dagmar and Bühlmeier, Judith and Libuda, Lars and Ludwig, Christine and Antel, Jochen}},
  issn         = {{1664-1078}},
  journal      = {{Frontiers in Psychology}},
  title        = {{{Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin}}},
  doi          = {{10.3389/fpsyg.2019.00769}},
  year         = {{2019}},
}

@article{27028,
  author       = {{Libuda, Lars and Hilbig, Annett and Berber-Al-Tawil, Seda and Kalhoff, Hermann and Kersting, Mathilde}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{523--531}},
  title        = {{{Association between full breastfeeding, timing of complementary food introduction, and iron status in infancy in Germany: results of a secondary analysis of a randomized trial}}},
  doi          = {{10.1007/s00394-016-1335-5}},
  year         = {{2018}},
}

@article{27029,
  author       = {{Hebebrand, Johannes and Peters, Triinu and Schijven, Dick and Hebebrand, Moritz and Grasemann, Corinna and Winkler, Thomas W. and Heid, Iris M. and Antel, Jochen and Föcker, Manuel and Tegeler, Lisa and Brauner, Lena and Adan, Roger A.H. and Luykx, Jurjen J. and Correll, Christoph U. and König, Inke R. and Hinney, Anke and Libuda, Lars}},
  issn         = {{2212-8778}},
  journal      = {{Molecular Metabolism}},
  pages        = {{1--11}},
  title        = {{{The role of genetic variation of human metabolism for BMI, mental traits and mental disorders}}},
  doi          = {{10.1016/j.molmet.2018.03.015}},
  year         = {{2018}},
}

@article{27030,
  author       = {{Föcker, Manuel and Antel, Jochen and Grasemann, Corinna and Führer, Dagmar and Timmesfeld, Nina and Öztürk, Dana and Peters, Triinu and Hinney, Anke and Hebebrand, Johannes and Libuda, Lars}},
  issn         = {{1471-244X}},
  journal      = {{BMC Psychiatry}},
  title        = {{{Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients – a randomized controlled trial: study protocol}}},
  doi          = {{10.1186/s12888-018-1637-7}},
  year         = {{2018}},
}

@article{27578,
  abstract     = {{<jats:title>Zusammenfassung</jats:title><jats:p>Neben monogenen Formen und Hauptgen-Effekten sind für die genetische Prädisposition zur Adipositas polygene Mechanismen relevant. Meta-Analysen von genom-weiten Assoziationsstudien (GWAMA) haben mehr als 700 polygene Loci oder Polygene identifiziert, die genom-weit mit dem Body Mass index (BMI) assoziiert sind. Diese prädisponierenden Genvarianten (Allele) finden sich bei adipösen Probanden häufiger als bei normalgewichtigen oder schlanken Individuen. Mittels statistischer Analysen wurden diese Allele als Adipositas-Risikoallele klassifiziert. Jede einzelne polygene Variante leistet nur einen kleinen Beitrag zur Entwicklung einer Adipositas und erhöht das Gewicht pro Risikoallel nur um ca. hundert Gramm bis 1,5 Kilogramm. Der Erfolg der GWAMA hat in letzter Zeit Phänotyp übergreifende, sogenannte Cross- Disorder- und Cross-Phänotyp-Analysen, ermöglicht. Dabei können Risiko-Gene identifiziert werden, die mittels Analysen der einzelnen Erkrankungen / Phänotypen nicht entdeckt werden konnten. Funktionelle Studien (in vitro und in vivo) der GWAMA-abgeleiteten Polygene können zu einem besseren Verständnis der Mechanismen der Körpergewichtsregulation führen.</jats:p>}},
  author       = {{Giuranna, J. and Antel, J. and Libuda, Lars and Reinehr, T. and Peters, T. and Hebebrand, J. and Hinney, A.}},
  issn         = {{1865-1739}},
  journal      = {{Adipositas - Ursachen, Folgeerkrankungen, Therapie}},
  pages        = {{176--182}},
  title        = {{{Polygene Formen der Adipositas und Störungs-übergreifende Analysen}}},
  doi          = {{10.1055/s-0038-1676674}},
  year         = {{2018}},
}

@article{27580,
  abstract     = {{<jats:title>Zusammenfassung</jats:title><jats:p>Wasser ist für Menschen das wichtigste Nahrungsmittel. Die Verfügbarkeit von ausreichend Trinkwasser in hoher Qualität hat große Bedeutung und ist weltweit ein herausforderndes Entwicklungsziel. Wasser hat im Körper viele Funktionen, etwa als Baustoff, Reaktionsmedium und Reaktionspartner oder als wichtiges Transportmedium. Ein gut regulierter Wasserhaushalt ist Voraussetzung für normale Körperfunktionen und für langfristige Gesundheit. Eine Dehydratation kann zu Symptomen wie Schwäche, niedrigem Blutdruck und Hypotonie führen und die Bewusstseinslage beeinträchtigen. Ein vollständiger Wasserentzug ist schon nach Tagen tödlich. Aber auch eine leichte Dehydratation beeinträchtigt langfristig die körperliche und geistige Leistungsfähigkeit. Angaben zum täglichen Wasserbedarf stützen sich vornehmlich auf epidemiologisch ermittelte Zufuhrdaten, die für gesunde Kinder und Jugendliche adäquat sind. Im Durchschnitt sollten Schulkinder etwa einen Liter und Jugendliche etwa 1,5 Liter täglich trinken. Zuckergesüßte Getränke mit hoher Energiedichte könnten das Risiko für Übergewicht und Adipositas erhöhen. Ein gesunder Getränkeverzehr kann mit Maßnahmen zur Verhaltensund zur Verhältnisprävention gefördert werden.</jats:p>}},
  author       = {{Hilbig, A. and Libuda, Lars and Kalhoff, H.}},
  issn         = {{1617-0288}},
  journal      = {{Kinder- und Jugendmedizin}},
  pages        = {{7--12}},
  title        = {{{Trinken – was und wie viel?}}},
  doi          = {{10.1055/s-0038-1629248}},
  year         = {{2018}},
}

@article{27027,
  author       = {{Bühlmeier, Judith and Harris, Carla and Koletzko, Sibylle and Lehmann, Irina and Bauer, Carl-Peter and Schikowski, Tamara and von Berg, Andrea and Berdel, Dietrich and Heinrich, Joachim and Hebebrand, Johannes and Föcker, Manuel and Standl, Marie and Libuda, Lars}},
  issn         = {{2072-6643}},
  journal      = {{Nutrients}},
  title        = {{{Dietary Acid Load and Mental Health Outcomes in Children and Adolescents: Results from the GINIplus and LISA Birth Cohort Studies}}},
  doi          = {{10.3390/nu10050582}},
  year         = {{2018}},
}

@article{27031,
  author       = {{Yang, Ming-zhe and Xue, Hong-mei and Pan, Jay and Libuda, Lars and Muckelbauer, Rebecca and Yang, Min and Quan, Liming and Cheng, Guo}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{1845--1854}},
  title        = {{{High protein intake along with paternal part-time employment is associated with higher body fat mass among girls from South China}}},
  doi          = {{10.1007/s00394-017-1468-1}},
  year         = {{2017}},
}

@article{27032,
  author       = {{Husmann, Christiane and Frank, Mirjam and Schmidt, Börge and Jöckel, Karl-Heinz and Antel, Jochen and Reissner, Volker and Libuda, Lars and Hebebrand, Johannes and Föcker, Manuel}},
  issn         = {{1932-6203}},
  journal      = {{PLOS ONE}},
  title        = {{{Low 25(OH)-vitamin D concentrations are associated with emotional and behavioral problems in German children and adolescents}}},
  doi          = {{10.1371/journal.pone.0183091}},
  year         = {{2017}},
}

@article{27033,
  author       = {{Libuda, Lars and Bolzenius, K and Alexy, U}},
  issn         = {{0954-3007}},
  journal      = {{European Journal of Clinical Nutrition}},
  pages        = {{1016--1018}},
  title        = {{{Breastfeeding trends in healthy infants since 1990—results of the DONALD study}}},
  doi          = {{10.1038/ejcn.2017.106}},
  year         = {{2017}},
}

@article{27522,
  author       = {{Föcker, Manuel and Antel, Jochen and Ring, Stefanie and Hahn, Denise and Kanal, Özlem and Öztürk, Dana and Hebebrand, Johannes and Libuda, Lars}},
  issn         = {{1018-8827}},
  journal      = {{European Child & Adolescent Psychiatry}},
  pages        = {{1043--1066}},
  title        = {{{Vitamin D and mental health in children and adolescents}}},
  doi          = {{10.1007/s00787-017-0949-3}},
  year         = {{2017}},
}

@article{27034,
  author       = {{Cadenas-Sanchez, Cristina and Vanhelst, Jeremy and Ruiz, Jonatan R. and Castillo-Gualda, Ruth and Libuda, Lars and Labayen, Idoia and De Miguel-Etayo, Pilar and Marcos, Ascensión and Molnár, Eszter and Catena, Andrés and Moreno, Luis A. and Sjöström, Michael and Gottrand, Frederic and Widhalm, Kurt and Ortega, Francisco B.}},
  issn         = {{1440-2440}},
  journal      = {{Journal of Science and Medicine in Sport}},
  pages        = {{373--379}},
  title        = {{{Fitness and fatness in relation with attention capacity in European adolescents: The HELENA study}}},
  doi          = {{10.1016/j.jsams.2016.08.003}},
  year         = {{2016}},
}

@article{27035,
  author       = {{Xue, Hongmei and Tian, Guo and Duan, Ruonan and Quan, Liming and Zhao, Li and Yang, Min and Libuda, Lars and Muckelbauer, Rebecca and Cheng, Guo}},
  issn         = {{2072-6643}},
  journal      = {{Nutrients}},
  title        = {{{Sedentary Behavior Is Independently Related to Fat Mass among Children and Adolescents in South China}}},
  doi          = {{10.3390/nu8110667}},
  year         = {{2016}},
}

@article{27036,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>Studies about effects of school lunch on children’s cognition are rare; two previous studies (CogniDo, CogniDo PLUS) generally found no negative effects of lunch on children’s cognitive performance at the end of lunch break (i.e. 45 min after finishing lunch), but suggested potential beneficial effects for single parameters. Therefore, the present study investigated the hypothesis of potential positive effects of school lunch on cognitive performance at early afternoon (90 min after finishing lunch). A randomised, cross-over intervention trial was conducted at a comprehensive school with fifth and sixth grade students. Participants were randomised into two groups: On day 1, group 1 did not eat lunch, whereas group 2 received lunch <jats:italic>ad libitum</jats:italic>. On day 2 (1 week later), group 2 did not eat lunch and group 1 received lunch <jats:italic>ad libitum</jats:italic>. The cognitive parameters task switching, working memory updating and alertness were tested using a computerised test battery 90 min after finishing the meal. Of the 204 recruited children, fifty were excluded because of deviations from the study protocol or absence on one of the 2 test days, which resulted in 154 participants. Data showed no significant effects of lunch on task switching, working memory updating and alertness (<jats:italic>P</jats:italic> values between 0·07 and 0·79). The present study suggests that school lunch does not seem to have beneficial effects on children’s cognitive functions regarding the conducted tests at early afternoon. Together with our previous studies, we conclude that school lunch in general has no negative effects on cognitive performance in children. However, beneficial effects seem to be restricted to a relatively short time period after eating lunch.</jats:p>}},
  author       = {{Schröder, Maike and Müller, Katrin and Falkenstein, Michael and Stehle, Peter and Kersting, Mathilde and Libuda, Lars}},
  issn         = {{0007-1145}},
  journal      = {{British Journal of Nutrition}},
  pages        = {{1298--1305}},
  title        = {{{Lunch at school and children’s cognitive functioning in the early afternoon: results from the Cognition Intervention Study Dortmund Continued (CoCo)}}},
  doi          = {{10.1017/s0007114516002932}},
  year         = {{2016}},
}

@article{27037,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>An intervention study showed that promoting water consumption in schoolchildren prevented overweight, but a mechanism linking water consumption to overweight was not substantiated. We investigated whether increased water consumption replaced sugar-containing beverages and whether changes in water or sugar-containing beverages influenced body weight outcomes. In a secondary analysis of the intervention study in Germany, we analysed combined longitudinal data from the intervention and control groups. Body weight and height were measured and beverage consumption was self-reported by a 24-h recall questionnaire at the beginning and end of the school year 2006/2007. The effect of a change in water consumption on change in sugar-containing beverage (soft drinks and juices) consumption, change in BMI (kg/m<jats:sup>2</jats:sup>) and prevalence of overweight and obesity at follow-up was analysed using regression analyses. Of 3220 enroled children, 1987 children (mean age 8·3 (<jats:sc>sd</jats:sc> 0·7) years) from thirty-two schools were analysed. Increased water consumption by 1 glass/d was associated with a reduced consumption of sugar-containing beverages by 0·12 glasses/d (95 % CI −0·16, −0·08) but was not associated with changes in BMI (<jats:italic>P</jats:italic>=0·63). Increased consumption of sugar-containing beverages by 1 glass/d was associated with an increased BMI by 0·02 (95 % CI 0·00, 0·03) kg/m<jats:sup>2</jats:sup> and increased prevalence of obesity (OR 1·22; 95 % CI 1·04, 1·44) but not with overweight (<jats:italic>P</jats:italic>=0·83). In conclusion, an increase in water consumption can replace sugar-containing beverages. As sugar-containing beverages were associated with weight gain, this replacement might explain the prevention of obesity through the promotion of water consumption.</jats:p>}},
  author       = {{Muckelbauer, Rebecca and Gortmaker, Steven L. and Libuda, Lars and Kersting, Mathilde and Clausen, Kerstin and Adelberger, Bettina and Müller-Nordhorn, Jacqueline}},
  issn         = {{0007-1145}},
  journal      = {{British Journal of Nutrition}},
  pages        = {{2057--2066}},
  title        = {{{Changes in water and sugar-containing beverage consumption and body weight outcomes in children}}},
  doi          = {{10.1017/s0007114516001136}},
  year         = {{2016}},
}

@article{27038,
  author       = {{Cheng, Guo and Duan, Ruonan and Kranz, Sibylle and Libuda, Lars and Zhang, Lishi}},
  issn         = {{2212-2672}},
  journal      = {{Journal of the Academy of Nutrition and Dietetics}},
  pages        = {{608--617}},
  title        = {{{Development of a Dietary Index to Assess Overall Diet Quality for Chinese School-Aged Children: The Chinese Children Dietary Index}}},
  doi          = {{10.1016/j.jand.2015.11.010}},
  year         = {{2016}},
}

@article{27523,
  author       = {{Libuda, Lars and Antel, J. and Hebebrand, J. and Föcker, M.}},
  issn         = {{0028-2804}},
  journal      = {{Der Nervenarzt}},
  pages        = {{87--101}},
  title        = {{{Ernährung und psychische Erkrankungen}}},
  doi          = {{10.1007/s00115-016-0262-2}},
  year         = {{2016}},
}

@article{27039,
  author       = {{Libuda, Lars and Mesch, Christina M. and Stimming, Madlen and Demmelmair, Hans and Koletzko, Berthold and Warschburger, Petra and Blanke, Katharina and Reischl, Eva and Kalhoff, Hermann and Kersting, Mathilde}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{1633--1644}},
  title        = {{{Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial}}},
  doi          = {{10.1007/s00394-015-0982-2}},
  year         = {{2015}},
}