@article{60973, abstract = {{The specific binding of DNA origami nanostructures (DONs) to bacteria is an important prerequisite for their application in pathogen targeting and antimicrobial drug delivery. So far, targeting bacteria with DONs has been achieved exclusively via aptamers, which suffer from drawbacks such as sensitivity toward environmental conditions and reduced binding after immobilization or conjugation. Here, an alternative approach is presented based on the modification of DONs with the cell wall‐binding glycopeptide antibiotic vancomycin. Using strain‐promoted azide‐alkyne cycloaddition, azide‐modified vancomycin is conjugated to selected staple strands and subsequently incorporated into 2D DON triangles. The resulting constructs show specific binding to the Gram‐positive species Bacillus subtilis (B. subtilis) and Staphylococcus capitis (S. capitis), and remarkably, to Gram‐negative Escherichia coli (E. coli), but no antimicrobial activity at vancomycin concentrations up to at least 2.91 μM. For B. subtilis and E. coli, DONs with vancomycin modifications on both sides exhibit better binding than DONs modified on only one side. However, both variants bind equally well to S. capitis. These results demonstrate the great potential of small molecule drug compounds for the robust, broad‐spectrum targeting of bacteria with DONs. Targeting a ubiquitous cell wall component of most pathogenic bacteria, vancomycin‐modified DONs have many potential applications in the prevention and treatment of nosocomial infections.}}, author = {{Coşkuner Leineweber, Özge and Pothineni, Bhanu K. and Schumann, Nils and Hofmann, Ulrike and Möser, Christin and Smith, David M. and Grundmeier, Guido and Zhang, Yixin and Keller, Adrian}}, issn = {{2688-4062}}, journal = {{Small Structures}}, publisher = {{Wiley}}, title = {{{Vancomycin‐Modified DNA Origami Nanostructures for Targeting Bacterial Pathogens}}}, doi = {{10.1002/sstr.202500246}}, year = {{2025}}, } @unpublished{60975, abstract = {{CP2K is a versatile open-source software package for simulations across a wide range of atomistic systems, from isolated molecules in the gas phase to low-dimensional functional materials and interfaces, as well as highly symmetric crystalline solids, disordered amorphous glasses, and weakly interacting soft-matter systems in the liquid state and in solution. This review highlights CP2K's capabilities for computing both static and dynamical properties using quantum-mechanical and classical simulation methods. In contrast to the accompanying theory and code paper [J. Chem. Phys. 152, 194103 (2020)], the focus here is on the practical usage and applications of CP2K, with underlying theoretical concepts introduced only as needed.}}, author = {{Iannuzzi, Marcella and Wilhelm, Jan and Stein, Frederick and Bussy, Augustin and Elgabarty, Hossam and Golze, Dorothea and Hehn, Anna and Graml, Maximilian and Marek, Stepan and Gökmen, Beliz Sertcan and Schran, Christoph and Forbert, Harald and Khaliullin, Rustam Z. and Kozhevnikov, Anton and Taillefumier, Mathieu and Meli, Rocco and Rybkin, Vladimir and Brehm, Martin and Schade, Robert and Schütt, Ole and Pototschnig, Johann V. and Mirhosseini, Hossein and Knüpfer, Andreas and Marx, Dominik and Krack, Matthias and Hutter, Jürg and Kühne, Thomas D.}}, booktitle = {{arXiv:2508.15559}}, title = {{{The CP2K Program Package Made Simple}}}, year = {{2025}}, } @inproceedings{58657, abstract = {{The rapid growth of 3D printing technology has transformed a wide range of industries, enabling the on-demand production of complex objects, from aerospace components to medical devices. However, this technology also introduces significant security challenges. Previous research highlighted the security implications of G-Codes—commands used to control the printing process. These studies assumed powerful attackers and focused on manipulations of the printed models, leaving gaps in understanding the full attack potential. In this study, we systematically analyze security threats associated with 3D printing, focusing specifically on vulnerabilities caused by G-Code commands. We introduce attacks and attacker models that assume a less powerful adversary than traditionally considered, broadening the scope of potential security threats. Our findings show that even minimal access to the 3D printer can result in significant security breaches, such as unauthorized access to subsequent print jobs or persistent misconfiguration of the printer. We identify 278 potentially malicious G-Codes across the attack categories Information Disclosure, Denial of Service, and Model Manipulation. Our evaluation demonstrates the applicability of these attacks across various 3D printers and their firmware. Our findings underscore the need for a better standardization process of G-Codes and corresponding security best practices. }}, author = {{Rossel, Jost and Mladenov, Vladislav and Wördenweber, Nico and Somorovsky, Juraj}}, booktitle = {{Proceedings of the 34th USENIX Security Symposium}}, location = {{Seattle, WA, USA}}, pages = {{1867 -- 1885}}, title = {{{Security Implications of Malicious G-Codes in 3D Printing}}}, year = {{2025}}, } @article{61003, author = {{Hasija, Tanuj and Kuschel, Maurice and Jackson, Michele and Dailey, Stephanie and Menne, Henric and Reinsberger, Claus and Vieluf, Solveig and Loddenkemper, Tobias}}, issn = {{0933-3657}}, journal = {{Artificial Intelligence in Medicine}}, publisher = {{Elsevier BV}}, title = {{{Improving wearable-based seizure prediction by feature fusion using an explainable growing network}}}, doi = {{10.1016/j.artmed.2025.103228}}, volume = {{169}}, year = {{2025}}, } @article{60996, abstract = {{Abstract The benefits of physical activity are undisputed. However, adverse events can occur in rare cases, particularly during high-intensity or prolonged exercise. During physical activity, at-risk patients can experience major cardiac events, whereas adverse events affecting the musculoskeletal system are more common but less severe. A sports preparticipation evaluation (PPE) for apparently healthy adults is designed to detect at-risk individuals and prevent potentially fatal events. This guideline for conducting PPEs was developed by consensus among 16 medical societies and sports associations and is based on previously published guidelines and consensus papers. Sports medicine physicians and potential participants were also surveyed to assess the recommendations’ content, feasibility, and implementation. On the basis of the 20 recommendations developed and agreed upon by the abovementioned entities, PPE comprises individuals’ personal, family, and sports histories, as well as a physical examination. The need for additional examinations (e.g., laboratory parameters, echocardiograms, or stress tests) is determined on the basis of the PPE findings. This approach’s feasibility in various regions, including resource-limited settings, and the extent to which it prevents adverse or potentially fatal events, should be examined in future research.}}, author = {{Joisten, Christine and Hirschmüller, Anja and Bauer, Pascal and Baum, Erika and Behrens, Meinolf and Berrisch-Rahmel, Susanne and Berrsche, Gregor and Carlsohn, Anja and Cassel, Michael and DeZeuuw, Justus and Dörr, Gesine and Dreher, Michael and Edelmann, Frank and Esefeld, Katrin and Freitag, Michael and Grebe, Mathias and Grim, Casper and Janßen, Pia and Kaiser, Rolf and Katlun, Thomas and Köppel, Maximilian and Kreutz, Charlotte and Krüger, Karsten and Lutter, Christoph and Mayer, Frank and Moser, Othmar and Nieß, Andreas and Predel, Hans-Georg and Peters, Stefan and Platen, Petra and Portius, Dorothea and Reinsberger, Claus and Reiss, Nils and Röcker, Kai and Schmidt, Thomas and Schmidt-Trucksäss, Arno and Schmitt, Holger and Schramm, Thomas and Sturm, Christian and Vater, Hans and Weise, Alina and Weisser, Burkhard and Welsch, Götz and Winkelmann, Andreas and Wirth, Alfred and Wolfarth, Bernd and Goossen, Käthe}}, issn = {{0112-1642}}, journal = {{Sports Medicine}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Sports Preparticipation Evaluation for Healthy Adults: A Consensus-Based German Guideline}}}, doi = {{10.1007/s40279-025-02230-5}}, year = {{2025}}, } @article{61015, author = {{Baier, Dominik and Kieke, Laureen and Voth, Sven and Kloß, Marvin and Huck, Marten and Steinrück, Hans-Georg and Tiemann, Michael}}, issn = {{2379-3694}}, journal = {{ACS Sensors}}, number = {{8}}, pages = {{5664--5673}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Selective H2 Gas Sensing Using ZIF-71/In-SnO2 Bilayer Sensors: A Size-Selective Molecular Sieving Approach}}}, doi = {{10.1021/acssensors.5c00770}}, volume = {{10}}, year = {{2025}}, } @article{61006, abstract = {{ Objective This cross-sectional study aimed to investigate subjective and objective deficits of neurocognitive function, balance and vestibulo-ocular performance in athletes with sport-related concussion (SRC) compared with healthy control athletes. Methods 72 patients with SRC and 72 matched healthy controls were included. All participants performed computerised testing of neurocognitive function, device-assisted balance testing and objective evaluation of vestibulo-ocular function (video head impulse and dynamic visual acuity test). Clinical symptom clusters (headache/migraine, anxiety/mood, fatigue, cognitive, vestibular, ocular) were determined for each patient using the Sport Concussion Assessment Tool, 5th edition symptom evaluation. Independent t-tests or Mann-Whitney U tests were calculated to test for group differences in the whole cohort and according to clinical symptom clusters. Results When investigating the whole cohort, significant differences between patients with SRC and control subjects were found in one parameter of balance testing (sway velocity double-firm), with lower performance in the SRC group (p<0.001, r=0.345). The number of symptom clusters assigned to the SRC patients ranged from 0 (no definite cluster) to 6 (all clusters), and all clusters were frequent in the investigated cohort. Patients with vestibular, cognitive and fatigue symptom clusters demonstrated significantly lower performance in balance testing compared with SRC patients without those clusters (p<0.001 to p=0.005, r=0.368–0.439). Additionally, SRC patients presenting with symptoms of the fatigue cluster demonstrated significantly worse performance in vestibulo-ocular testing compared with SRC patients without the fatigue cluster (p=0.006, d=0.781). Conclusion SRC patients presented with variable numbers and qualities of clinical symptom clusters. Some subjective clusters were associated with abnormal objective tests of other clusters (vestibular, cognitive and fatigue with abnormal balance; and fatigue with abnormal vestibulo-ocular performance). Clinical symptom clusters and their overlap should be considered when examining patients with SRC. }}, author = {{Weike, Lea and Reeschke, Rebecca and Reinsberger, Claus}}, issn = {{2055-7647}}, journal = {{BMJ Open Sport & Exercise Medicine}}, number = {{3}}, publisher = {{BMJ}}, title = {{{Clinical symptom clusters, neurocognitive function, balance and vestibulo-ocular function in athletes with sport-related concussion}}}, doi = {{10.1136/bmjsem-2024-002447}}, volume = {{11}}, year = {{2025}}, } @article{61000, author = {{van den Bongard, Franziska and Petersen, Catharina and Reinsberger, Claus}}, issn = {{2589-9864}}, journal = {{Epilepsy & Behavior Reports}}, publisher = {{Elsevier BV}}, title = {{{Safety and feasibility of exhaustive exercise testing for people with epilepsy}}}, doi = {{10.1016/j.ebr.2025.100762}}, volume = {{30}}, year = {{2025}}, } @article{61007, abstract = {{ABSTRACT Purpose Repetitive head impacts due to heading in soccer may bear the potential to induce brain changes. To investigate how brain development is affected by heading, effects of heading exposure on neurocognitive and vestibular performance in adolescent soccer players were prospectively examined. Methods In this longitudinal cohort study, male and female high-level youth soccer players of different ages were enrolled in two seasons. Age-matched athletes of other ball sports were included as controls. Before and after each season, neurocognitive performance (6 domain scores), vestibulo-ocular reflex, dynamic visual acuity, and postural control (sway velocity) were objectively assessed in all athletes. Every soccer training and match during the observation period was videotaped to analyze individual heading exposure. Associations between heading frequency (total, in duels, >20 m flight distance) and pre- to post-changes were investigated via Spearman correlation. Results 103 soccer and 51 control athletes (9-19 years) participated. Neurocognitive scores and sway velocity significantly improved in each season in soccer and control athletes. There were no associations between total heading numbers and changes in any parameter. Over the first season, the more headers played in duels (r = -0.255, 95%CI = -0.474 to -0.006, p = 0.04) and from >20 m distance (r = -0.299, 95%CI = -0.510 to -0.055, p = 0.02) the less psychomotor speed improvement occurred. In the second season, improvements in reaction time were significantly smaller with higher numbers of headers played in duels (r = 0.375, 95%CI = 0.043 to 0.632, p = 0.02) and from >20 m distance (r = 0.359, 95%CI = 0.025 to 0.621, p = 0.03). Conclusions Potential high-impact headers may have affected neurocognitive improvements, exhibiting small to moderate effects. Therefore, more high-impact headers may be more important to consider than solely the overall heading exposure in discussions about adverse effects in youth soccer. }}, author = {{Reeschke, Rebecca and Dautzenberg, Lena and Mund, Franziska Katharina and Koch, Thorsten and Reinsberger, Claus}}, issn = {{1530-0315}}, journal = {{Medicine & Science in Sports & Exercise}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Effects of Different Header Types on Neurocognitive and Vestibular Performance in Youth Soccer Players}}}, doi = {{10.1249/mss.0000000000003831}}, year = {{2025}}, } @misc{60601, author = {{Breckner, Anne}}, title = {{{ZeKK Live - 45 Minuten mit Dr. Yasemin El-Menouar}}}, year = {{2025}}, } @article{61042, abstract = {{We introduce the concept of a k-token signed graph and study some of its combinatorial and algebraic properties. We prove that two switching isomorphic signed graphs have switching isomorphic token graphs. Moreover, we show that the Laplacian spectrum of a balanced signed graph is contained in the Laplacian spectra of its k-token signed graph. Besides, we introduce and study the unbalance level of a signed graph, which is a new parameter that measures how far a signed graph is from being balanced. Moreover, we study the relation between the frustration index and the unbalance level of signed graphs and their token signed graphs.}}, author = {{Dalfó, C. and Fiol, M. A. and Steffen, Eckhard}}, issn = {{0925-9899}}, journal = {{Journal of Algebraic Combinatorics}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{On token signed graphs}}}, doi = {{10.1007/s10801-025-01416-4}}, volume = {{62}}, year = {{2025}}, } @inproceedings{61047, author = {{Rautenberg, Frederik and Seebauer, Fritz and Wiechmann, Jana and Kuhlmann, Michael and Wagner, Petra and Haeb-Umbach, Reinhold}}, booktitle = {{Interspeech 2025}}, location = {{Rotterdam}}, publisher = {{ISCA}}, title = {{{Synthesizing Speech with Selected Perceptual Voice Qualities – A Case Study with Creaky Voice}}}, doi = {{10.21437/Interspeech.2025-1443}}, year = {{2025}}, } @inproceedings{61057, abstract = {{Verification and Validation (V&V) are essential processes in engineering Cyber-Physical Systems. However, the role of V&V engineers is often not given sufficient attention. Based on a systematic literature analysis and practical observations, a four-step method for Test-oriented Resilient Requirements Engineering (ToRRE) is developed. The steps are planning V&V, executing V&V activities, documenting V&V activities and analyzing results of V&V activities. Applying ToRRE ensures continuous information flow and traceability. Engineers are enabled to analyze requirements using engineering artifacts connected through Model-Based Systems Engineering. Adopting methods for Model-Based Effect Chain analysis to evaluated test cases and test scenarios, conclusions on requirements engineering and change management are enabled. The method is evaluated in an EU research project.}}, author = {{Gräßler, Iris and Ebel, Marcel}}, booktitle = {{Proceedings of the Design Society}}, issn = {{2732-527X}}, keywords = {{systems engineering (SE), product modelling/models, design methods, verification & validation, test cases & test scenarios}}, location = {{Dallas, Texas, USA}}, pages = {{3031--3040}}, publisher = {{Cambridge University Press (CUP)}}, title = {{{Test-oriented Resilient Requirements Engineering (ToRRE): extending model-based effect chain analysis to verification objectives}}}, doi = {{10.1017/pds.2025.10317}}, volume = {{5}}, year = {{2025}}, } @article{60719, abstract = {{Abstract Background Parkinson’s Disease (PD) bears a variety of sex differences and is associated with cardiovascular dysregulation (CDR). Variation in the routinely assessed standard parameters heart rate (HR) and blood pressure (BP) seem not well understood within the frame of sex-specific developments under therapy. Parameters of heart rate variability (RMSSD) and electrodermal activity (meanEDA) may assist the understanding of underlying autonomic developments. This pilot study aims to describe sex-specific cardiovascular and autonomic responses to a multimodal inpatient rehabilitation program in patients with PD. Methods Forty-one PD patients (24 male, 17 female) participated in a stationary, multimodal therapy intervention (MTI). Before and after MTI, HR, BP, RMSSD, and meanEDA were assessed in supine baseline (5 min of rest before orthostasis) and during supine adaption to rest (5 min of rest after orthostasis). Differences between baseline and adaption to rest as well as differences over time of MTI were calculated using Wilcoxon test; sex differences using Mann–Whitney-U test. Results Before MTI, women’s supine HR (p = .034*; d = .17) and BP (p = .015*, d = 0.4) were significantly higher during adaption to rest than during baseline. After MTI, women’s supine HR (p = .020*; d = .84) and BP (p = .022*, d = 0.5) during adaption to rest had decreased significantly. Men’s HR and BP remained constant and without differences between the supine conditions. RMSSD and meanEDA remained steady in both sexes. Conclusion The sex-specific responsiveness to MTI supports the concept of sex-sensitive therapeutic management for cardiovascular symptoms in PD. In both sexes, peripheral cardiovascular outcomes appeared not attributable to corresponding outcomes in autonomic regulation. Further examination of autonomic parameters could provide a foundation for developing therapeutic approaches that address central nervous system mechanisms. The study was officially registered (08/2020). The data supporting the findings of this study are available under http://apps.who.int/trialsearch/ under trial number DRKS00022773. }}, author = {{Siche-Pantel, Franziska and Mühlenberg, Manfred and Buschfort, Rüdiger and Michels, Heinke and Jakobsmeyer, Rasmus and Oesterschlink, Julian and Reinsberger, Claus}}, issn = {{1471-2377}}, journal = {{BMC Neurology}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study}}}, doi = {{10.1186/s12883-025-04281-7}}, volume = {{25}}, year = {{2025}}, } @inproceedings{61060, abstract = {{In early operational phases of severe weather events, a lack of information challenges emergency management teams to gain an overview of the situation and make informed decisions. To support situational exploration, unmanned aerial and ground vehicles attract increasing attention, primarily used to document operational sites. However, they offer further potential in early operational phases. To ensure their reliable use for exploration, decision-makers must be aware of opportunities and limitations under prevailing conditions. For this, use cases for robotic simulation in emergency response are presented, considering technical restrictions and dynamic influences from weather impacts. The approach of integrating rescue robot simulation into the response phase is developed following a five-step research design. Existing use cases of rescue robot simulation are identified in a systematic literature analysis. The results are extended with use cases developed for urban flooding scenarios. Subsequently, use cases are assessed and selected for implementation in the simulation environment Gazebo. Finally, the results are validated with end users in the EU research project CREXDATA, which focuses on decision support based on processing extreme data. The implemented use cases demonstrate the potential of robotic simulation in emergency response to accelerate action planning in decisionmaking and provide a more detailed picture, enabling betterinformed decisions. }}, author = {{Gräßler, Iris and Döhner, Niklas and Ebel, Marcel and Pottebaum, Jens}}, booktitle = {{Mensch und Computer 2025 - Workshopband}}, keywords = {{robotic simulation, rescue robots, emergency response, extreme weather}}, location = {{Chemnitz}}, title = {{{Shifting boundaries from preparedness to response: Using simulation of rescue robots in weather-induced emergencies}}}, doi = {{10.18420/muc2025-mci-ws01-187}}, year = {{2025}}, } @inproceedings{61090, author = {{Adler, Enno and Böttcher, Stefan and Hartel, Rita and Steininger, Cedric Alexander}}, booktitle = {{23rd International Symposium on Experimental Algorithms}}, pages = {{2:1----2:18}}, publisher = {{Schloss Dagstuhl - Leibniz-Zentrum für Informatik}}, title = {{{IBB: Fast Burrows-Wheeler Transform Construction for Length-Diverse DNA Data}}}, volume = {{228}}, year = {{2025}}, } @misc{59564, author = {{Peckhaus, Volker}}, booktitle = {{zbMATH Open, Zbl. 07925543}}, title = {{{Hermann, Michael, „Der Wandel von Statistik zu Maschinellem Lernen“, SieB. Siegener Beiträge zur Geschichte und Philosophie der Mathematik 17 (2023), 145–179. }}}, year = {{2025}}, } @inproceedings{61109, author = {{Pottebaum, Jens and Gräßler, Iris and Ebel, Marcel and Özcan, Deniz and Döhner, Niklas and Pratzler-Wanczura, Sylvia and Derin, Enes and Krüger, Oliver and Kruijff-Korbayova, Ivana and Stampa, Merlin}}, location = {{Koblenz, Deutschland}}, pages = {{81--94}}, publisher = {{LibreCat University}}, title = {{{EU-Projekt CREXDATA: Erkenntnisse und Handlungsempfehlungen zum Einsatz KI-generierter Lageinformationen für die Lagebewertung und Maßnahmenplanung in Extremwetterlagen}}}, doi = {{10.5281/ZENODO.16740824}}, year = {{2025}}, } @article{61108, abstract = {{Greybox fuzzing is used extensively in research and practice. There are umpteen publications that improve greybox fuzzing. However, to what extent do these improvements affect the internal components or internals of a given fuzzer is not yet understood as the improvements are mostly evaluated using code coverage and bug finding capability. Such an evaluation is insufficient to understand the effect of improvements on the fuzzer internals. Some of the literature visualizes the outcomes of fuzzing to enhance the understanding. However, they only focus on high-level information and no previous research on visualization has been dedicated to understanding fuzzing internals. To close this gap, we propose the first step towards development of a fuzzing-specific visualization framework: a taxonomy of visualization analysis tasks that fuzzing experts desire to help them understand the fuzzing internals. Our approach involves conducting interviews with fuzzing experts and using qualitative data analysis to systematically extract the task taxonomy from the interview data. We also evaluate the support of existing fuzzing visualization tools through the lens of our taxonomy. In our study, we have conducted 33 interviews with fuzzing practitioners and extracted a taxonomy of 120 visualization analysis tasks. Our evaluation shows that the existing fuzzing visualization tools only provide aids to support 10 of them.}}, author = {{Kummita, Sriteja and Miao, Miao and Bodden, Eric and Wei, Shiyi}}, issn = {{1049-331X}}, journal = {{ACM Transactions on Software Engineering and Methodology}}, publisher = {{Association for Computing Machinery (ACM)}}, title = {{{Visualization Task Taxonomy to Understand the Fuzzing Internals}}}, doi = {{10.1145/3718346}}, year = {{2025}}, } @article{55090, author = {{Grewe, Felix}}, issn = {{2468-4414}}, journal = {{Feminist Encounters Special Issue on Peripheral Visions of Alternative Futures: Feminist Techno-imaginaries}}, number = {{2}}, publisher = {{lectito}}, title = {{{The Need for Diffraction in STEM -fields: An Ethical Feminist Consideration of the Concept of Genderscripting}}}, doi = {{10.20897/femenc/16786 }}, volume = {{9}}, year = {{2025}}, }