---
_id: '27725'
abstract:
- lang: eng
  text: <jats:p> Whether prepubertal estrogen production impacts on the timing of
    puberty is not clear. We aimed to investigate prepubertal 24-h estrogen excretion
    levels and their association with early and late pubertal markers. Daily urinary
    excretion rates of estrogens of 132 healthy children, who provided 24-h urine
    samples 1 and 2 yr before the start of the pubertal growth spurt [age at takeoff
    (ATO)], were quantified by stable isotope dilution/GC-MS. E-sum3 (estrone + estradiol
    + estriol) was used as a marker for potentially bioactive estrogen metabolites
    and E-sum5 (E-sum3 + 16-epiestriol + 16-ketoestradiol) for total estrogen production.
    Pubertal outcomes were ATO, age at peak height velocity (APHV), duration of pubertal
    growth acceleration (APHV-ATO), age at Tanner stage 2 for pubic hair (PH2), genital
    (G2, boys) and breast (B2, girls) development, and age at menarche. Prepubertal
    urinary estrogen excretions (E-sum3 and E-sum5) were not associated with ATO,
    APHV, and age at PH2 but with duration of pubertal growth acceleration ( P &lt;
    0.01) in both sexes. Girls with higher E-sum3 reached B2 0.9 yr ( P = 0.04) and
    menarche 0.3 yr earlier ( P = 0.04) than girls with lower E-sum3. E-sum3 was not
    associated with age at G2 in boys ( P = 0.6). For most pubertal variables, the
    associations with E-sum3 were stronger than with E-sum5. In conclusion, prepubertal
    estrogens may not be critical for the onset of the pubertal growth spurt but are
    correlated with its duration in both boys and girls. Prepubertal estrogen levels
    may already predict the timing of girls' menstruation and breast development but
    do not appear to affect sexual maturation in boys. </jats:p>
author:
- first_name: Lijie
  full_name: Shi, Lijie
  last_name: Shi
- first_name: Thomas
  full_name: Remer, Thomas
  last_name: Remer
- first_name: Anette
  full_name: Buyken, Anette
  id: '65985'
  last_name: Buyken
- first_name: Michaela F.
  full_name: Hartmann, Michaela F.
  last_name: Hartmann
- first_name: Philipp
  full_name: Hoffmann, Philipp
  last_name: Hoffmann
- first_name: Stefan A.
  full_name: Wudy, Stefan A.
  last_name: Wudy
citation:
  ama: Shi L, Remer T, Buyken A, Hartmann MF, Hoffmann P, Wudy SA. Prepubertal urinary
    estrogen excretion and its relationship with pubertal timing. <i>American Journal
    of Physiology-Endocrinology and Metabolism</i>. Published online 2010:E990-E997.
    doi:<a href="https://doi.org/10.1152/ajpendo.00374.2010">10.1152/ajpendo.00374.2010</a>
  apa: Shi, L., Remer, T., Buyken, A., Hartmann, M. F., Hoffmann, P., &#38; Wudy,
    S. A. (2010). Prepubertal urinary estrogen excretion and its relationship with
    pubertal timing. <i>American Journal of Physiology-Endocrinology and Metabolism</i>,
    E990–E997. <a href="https://doi.org/10.1152/ajpendo.00374.2010">https://doi.org/10.1152/ajpendo.00374.2010</a>
  bibtex: '@article{Shi_Remer_Buyken_Hartmann_Hoffmann_Wudy_2010, title={Prepubertal
    urinary estrogen excretion and its relationship with pubertal timing}, DOI={<a
    href="https://doi.org/10.1152/ajpendo.00374.2010">10.1152/ajpendo.00374.2010</a>},
    journal={American Journal of Physiology-Endocrinology and Metabolism}, author={Shi,
    Lijie and Remer, Thomas and Buyken, Anette and Hartmann, Michaela F. and Hoffmann,
    Philipp and Wudy, Stefan A.}, year={2010}, pages={E990–E997} }'
  chicago: Shi, Lijie, Thomas Remer, Anette Buyken, Michaela F. Hartmann, Philipp
    Hoffmann, and Stefan A. Wudy. “Prepubertal Urinary Estrogen Excretion and Its
    Relationship with Pubertal Timing.” <i>American Journal of Physiology-Endocrinology
    and Metabolism</i>, 2010, E990–97. <a href="https://doi.org/10.1152/ajpendo.00374.2010">https://doi.org/10.1152/ajpendo.00374.2010</a>.
  ieee: 'L. Shi, T. Remer, A. Buyken, M. F. Hartmann, P. Hoffmann, and S. A. Wudy,
    “Prepubertal urinary estrogen excretion and its relationship with pubertal timing,”
    <i>American Journal of Physiology-Endocrinology and Metabolism</i>, pp. E990–E997,
    2010, doi: <a href="https://doi.org/10.1152/ajpendo.00374.2010">10.1152/ajpendo.00374.2010</a>.'
  mla: Shi, Lijie, et al. “Prepubertal Urinary Estrogen Excretion and Its Relationship
    with Pubertal Timing.” <i>American Journal of Physiology-Endocrinology and Metabolism</i>,
    2010, pp. E990–97, doi:<a href="https://doi.org/10.1152/ajpendo.00374.2010">10.1152/ajpendo.00374.2010</a>.
  short: L. Shi, T. Remer, A. Buyken, M.F. Hartmann, P. Hoffmann, S.A. Wudy, American
    Journal of Physiology-Endocrinology and Metabolism (2010) E990–E997.
date_created: 2021-11-23T15:44:42Z
date_updated: 2022-01-06T06:57:44Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.1152/ajpendo.00374.2010
language:
- iso: eng
page: E990-E997
publication: American Journal of Physiology-Endocrinology and Metabolism
publication_identifier:
  issn:
  - 0193-1849
  - 1522-1555
publication_status: published
status: public
title: Prepubertal urinary estrogen excretion and its relationship with pubertal timing
type: journal_article
user_id: '61597'
year: '2010'
...