---
_id: '35657'
abstract:
- lang: eng
  text: The controlled delivery of active pharmaceutical ingredients to the site of
    disease represents a major challenge in drug therapy. Particularly when drugs
    have to be transported across biological barriers, suitable drug delivery systems
    are of importance. In recent years responsive delivery systems have been developed
    which enable a controlled drug release depending on internal or external stimuli
    such as changes in pH, redox environment or light and temperature. In some studies
    delivery systems with reactivity against two different stimuli were established
    either to enhance the response by synergies of the stimuli or to broaden the window
    of possible trigger events. In the present review numerous exciting developments
    of pH-, light- and redox-cleavable polymers suitable for the preparation of smart
    delivery systems are described. The review discusses the different stimuli that
    can be used for a controlled drug release of polymer-based delivery systems. It
    puts a focus on the different polymers described for the preparation of stimuli-sensitive
    systems, their preparation techniques as well as their stimuli-responsive degradation.
    © 2022 The Authors. Polymer International published by John Wiley & Sons Ltd on
    behalf of Society of Industrial Chemistry.
article_type: original
author:
- first_name: Tarik
  full_name: Rust, Tarik
  last_name: Rust
- first_name: Dimitri
  full_name: Jung, Dimitri
  last_name: Jung
- first_name: Klaus
  full_name: Langer, Klaus
  last_name: Langer
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Rust T, Jung D, Langer K, Kuckling D. Stimuli‐accelerated polymeric drug delivery
    systems. <i>Polymer International</i>. 2023;72(1):5-19. doi:<a href="https://doi.org/10.1002/pi.6474">10.1002/pi.6474</a>
  apa: Rust, T., Jung, D., Langer, K., &#38; Kuckling, D. (2023). Stimuli‐accelerated
    polymeric drug delivery systems. <i>Polymer International</i>, <i>72</i>(1), 5–19.
    <a href="https://doi.org/10.1002/pi.6474">https://doi.org/10.1002/pi.6474</a>
  bibtex: '@article{Rust_Jung_Langer_Kuckling_2023, title={Stimuli‐accelerated polymeric
    drug delivery systems}, volume={72}, DOI={<a href="https://doi.org/10.1002/pi.6474">10.1002/pi.6474</a>},
    number={1}, journal={Polymer International}, publisher={Wiley}, author={Rust,
    Tarik and Jung, Dimitri and Langer, Klaus and Kuckling, Dirk}, year={2023}, pages={5–19}
    }'
  chicago: 'Rust, Tarik, Dimitri Jung, Klaus Langer, and Dirk Kuckling. “Stimuli‐accelerated
    Polymeric Drug Delivery Systems.” <i>Polymer International</i> 72, no. 1 (2023):
    5–19. <a href="https://doi.org/10.1002/pi.6474">https://doi.org/10.1002/pi.6474</a>.'
  ieee: 'T. Rust, D. Jung, K. Langer, and D. Kuckling, “Stimuli‐accelerated polymeric
    drug delivery systems,” <i>Polymer International</i>, vol. 72, no. 1, pp. 5–19,
    2023, doi: <a href="https://doi.org/10.1002/pi.6474">10.1002/pi.6474</a>.'
  mla: Rust, Tarik, et al. “Stimuli‐accelerated Polymeric Drug Delivery Systems.”
    <i>Polymer International</i>, vol. 72, no. 1, Wiley, 2023, pp. 5–19, doi:<a href="https://doi.org/10.1002/pi.6474">10.1002/pi.6474</a>.
  short: T. Rust, D. Jung, K. Langer, D. Kuckling, Polymer International 72 (2023)
    5–19.
date_created: 2023-01-10T08:25:22Z
date_updated: 2023-01-10T08:31:31Z
department:
- _id: '163'
doi: 10.1002/pi.6474
intvolume: '        72'
issue: '1'
keyword:
- drug delivery system
- stimuli
- polymer
- cleavable
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/pi.6474
page: 5-19
publication: Polymer International
publication_identifier:
  issn:
  - 0959-8103
  - 1097-0126
publication_status: published
publisher: Wiley
status: public
title: Stimuli‐accelerated polymeric drug delivery systems
type: journal_article
user_id: '94'
volume: 72
year: '2023'
...