---
_id: '53772'
abstract:
- lang: eng
  text: '<jats:title>Abstract</jats:title><jats:p>Background: It is unknown whether
    dietary recommendations for cancer prevention are applicable to the elderly. We
    analyzed WCRF/AICR recommendations in cohorts of European and U.S. adults ages
    60 years and above.</jats:p><jats:p>Methods: Individual participant data meta-analysis
    included 362,114 participants (43% women), from seven prospective cohort studies,
    free from cancer at enrollment. The WCRF/AICR diet score was based on: (i) energy-dense
    foods and sugary drinks, (ii) plant foods, (iii) red and processed meat, and (iv)
    alcoholic drinks. Cox proportional hazards regression was used to examine the
    association between the diet score and cancer risks. Adjusted, cohort-specific
    HRs were pooled using random-effects meta-analysis. Risk advancement periods (RAP)
    were calculated to quantify the time period by which the risk of cancer was postponed
    among those adhering to the recommendations.</jats:p><jats:p>Results: After a
    median follow-up of 11 to 15 years across cohorts, 70,877 cancer cases were identified.
    Each one-point increase in the WCRF/AICR diet score [range, 0 (no) to 4 (complete
    adherence)] was significantly associated with a lower risk of total cancer [HR,
    0.94; 95% confidence interval (CI), 0.92–0.97], cancers of the colorectum (HR,
    0.84; 95% CI, 0.80–0.89) and prostate (HR, 0.94; 95% CI, 0.92–0.97), but not breast
    or lung. Adherence to an additional component of the WCRF/AICR diet score significantly
    postponed the incidence of cancer at any site by 1.6 years (RAP, −1.6; 95% CI,
    −4.09 to −2.16).</jats:p><jats:p>Conclusions: Adherence to WCRF/AICR dietary recommendations
    is associated with lower risk of cancer among older adults.</jats:p><jats:p>Impact:
    Dietary recommendations for cancer prevention are applicable to the elderly. Cancer
    Epidemiol Biomarkers Prev; 26(1); 136–44. ©2016 AACR.</jats:p>'
author:
- first_name: Nicole
  full_name: Jankovic, Nicole
  last_name: Jankovic
- first_name: Anouk
  full_name: Geelen, Anouk
  last_name: Geelen
- first_name: Renate M.
  full_name: Winkels, Renate M.
  last_name: Winkels
- first_name: Blaise
  full_name: Mwungura, Blaise
  last_name: Mwungura
- first_name: Veronika
  full_name: Fedirko, Veronika
  last_name: Fedirko
- first_name: Mazda
  full_name: Jenab, Mazda
  last_name: Jenab
- first_name: Anne K.
  full_name: Illner, Anne K.
  last_name: Illner
- first_name: Hermann
  full_name: Brenner, Hermann
  last_name: Brenner
- first_name: José M.
  full_name: Ordóñez-Mena, José M.
  last_name: Ordóñez-Mena
- first_name: Jessica C.
  full_name: Kiefte de Jong, Jessica C.
  last_name: Kiefte de Jong
- first_name: Oscar H.
  full_name: Franco, Oscar H.
  last_name: Franco
- first_name: Philippos
  full_name: Orfanos, Philippos
  last_name: Orfanos
- first_name: Antonia
  full_name: Trichopoulou, Antonia
  last_name: Trichopoulou
- first_name: Paolo
  full_name: Boffetta, Paolo
  last_name: Boffetta
- first_name: Antonio
  full_name: Agudo, Antonio
  last_name: Agudo
- first_name: Petra H.
  full_name: Peeters, Petra H.
  last_name: Peeters
- first_name: Anne
  full_name: Tjønneland, Anne
  last_name: Tjønneland
- first_name: Göran
  full_name: Hallmans, Göran
  last_name: Hallmans
- first_name: H. Bas
  full_name: Bueno-de-Mesquita, H. Bas
  last_name: Bueno-de-Mesquita
- first_name: Yikyung
  full_name: Park, Yikyung
  last_name: Park
- first_name: Edith J.
  full_name: Feskens, Edith J.
  last_name: Feskens
- first_name: Lisette C.
  full_name: de Groot, Lisette C.
  last_name: de Groot
- first_name: Ellen
  full_name: Kampman, Ellen
  last_name: Kampman
citation:
  ama: 'Jankovic N, Geelen A, Winkels RM, et al. Adherence to the WCRF/AICR Dietary
    Recommendations for Cancer Prevention and Risk of Cancer in Elderly from Europe
    and the United States: A Meta-Analysis within the CHANCES Project. <i>Cancer Epidemiology,
    Biomarkers &#38;amp; Prevention</i>. 2016;26(1):136-144. doi:<a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>'
  apa: 'Jankovic, N., Geelen, A., Winkels, R. M., Mwungura, B., Fedirko, V., Jenab,
    M., Illner, A. K., Brenner, H., Ordóñez-Mena, J. M., Kiefte de Jong, J. C., Franco,
    O. H., Orfanos, P., Trichopoulou, A., Boffetta, P., Agudo, A., Peeters, P. H.,
    Tjønneland, A., Hallmans, G., Bueno-de-Mesquita, H. B., … Kampman, E. (2016).
    Adherence to the WCRF/AICR Dietary Recommendations for Cancer Prevention and Risk
    of Cancer in Elderly from Europe and the United States: A Meta-Analysis within
    the CHANCES Project. <i>Cancer Epidemiology, Biomarkers &#38;amp; Prevention</i>,
    <i>26</i>(1), 136–144. <a href="https://doi.org/10.1158/1055-9965.epi-16-0428">https://doi.org/10.1158/1055-9965.epi-16-0428</a>'
  bibtex: '@article{Jankovic_Geelen_Winkels_Mwungura_Fedirko_Jenab_Illner_Brenner_Ordóñez-Mena_Kiefte
    de Jong_et al._2016, title={Adherence to the WCRF/AICR Dietary Recommendations
    for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United
    States: A Meta-Analysis within the CHANCES Project}, volume={26}, DOI={<a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>},
    number={1}, journal={Cancer Epidemiology, Biomarkers &#38;amp; Prevention}, publisher={American
    Association for Cancer Research (AACR)}, author={Jankovic, Nicole and Geelen,
    Anouk and Winkels, Renate M. and Mwungura, Blaise and Fedirko, Veronika and Jenab,
    Mazda and Illner, Anne K. and Brenner, Hermann and Ordóñez-Mena, José M. and Kiefte
    de Jong, Jessica C. and et al.}, year={2016}, pages={136–144} }'
  chicago: 'Jankovic, Nicole, Anouk Geelen, Renate M. Winkels, Blaise Mwungura, Veronika
    Fedirko, Mazda Jenab, Anne K. Illner, et al. “Adherence to the WCRF/AICR Dietary
    Recommendations for Cancer Prevention and Risk of Cancer in Elderly from Europe
    and the United States: A Meta-Analysis within the CHANCES Project.” <i>Cancer
    Epidemiology, Biomarkers &#38;amp; Prevention</i> 26, no. 1 (2016): 136–44. <a
    href="https://doi.org/10.1158/1055-9965.epi-16-0428">https://doi.org/10.1158/1055-9965.epi-16-0428</a>.'
  ieee: 'N. Jankovic <i>et al.</i>, “Adherence to the WCRF/AICR Dietary Recommendations
    for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United
    States: A Meta-Analysis within the CHANCES Project,” <i>Cancer Epidemiology, Biomarkers
    &#38;amp; Prevention</i>, vol. 26, no. 1, pp. 136–144, 2016, doi: <a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>.'
  mla: 'Jankovic, Nicole, et al. “Adherence to the WCRF/AICR Dietary Recommendations
    for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United
    States: A Meta-Analysis within the CHANCES Project.” <i>Cancer Epidemiology, Biomarkers
    &#38;amp; Prevention</i>, vol. 26, no. 1, American Association for Cancer Research
    (AACR), 2016, pp. 136–44, doi:<a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>.'
  short: N. Jankovic, A. Geelen, R.M. Winkels, B. Mwungura, V. Fedirko, M. Jenab,
    A.K. Illner, H. Brenner, J.M. Ordóñez-Mena, J.C. Kiefte de Jong, O.H. Franco,
    P. Orfanos, A. Trichopoulou, P. Boffetta, A. Agudo, P.H. Peeters, A. Tjønneland,
    G. Hallmans, H.B. Bueno-de-Mesquita, Y. Park, E.J. Feskens, L.C. de Groot, E.
    Kampman, Cancer Epidemiology, Biomarkers &#38;amp; Prevention 26 (2016) 136–144.
date_created: 2024-04-29T11:06:38Z
date_updated: 2024-04-29T11:07:45Z
doi: 10.1158/1055-9965.epi-16-0428
intvolume: '        26'
issue: '1'
language:
- iso: eng
page: 136-144
publication: Cancer Epidemiology, Biomarkers &amp; Prevention
publication_identifier:
  issn:
  - 1055-9965
  - 1538-7755
publication_status: published
publisher: American Association for Cancer Research (AACR)
status: public
title: 'Adherence to the WCRF/AICR Dietary Recommendations for Cancer Prevention and
  Risk of Cancer in Elderly from Europe and the United States: A Meta-Analysis within
  the CHANCES Project'
type: journal_article
user_id: '105192'
volume: 26
year: '2016'
...
---
_id: '53773'
abstract:
- lang: eng
  text: '<jats:title>Abstract</jats:title><jats:p>Background: It is unknown whether
    dietary recommendations for cancer prevention are applicable to the elderly. We
    analyzed WCRF/AICR recommendations in cohorts of European and U.S. adults ages
    60 years and above.</jats:p><jats:p>Methods: Individual participant data meta-analysis
    included 362,114 participants (43% women), from seven prospective cohort studies,
    free from cancer at enrollment. The WCRF/AICR diet score was based on: (i) energy-dense
    foods and sugary drinks, (ii) plant foods, (iii) red and processed meat, and (iv)
    alcoholic drinks. Cox proportional hazards regression was used to examine the
    association between the diet score and cancer risks. Adjusted, cohort-specific
    HRs were pooled using random-effects meta-analysis. Risk advancement periods (RAP)
    were calculated to quantify the time period by which the risk of cancer was postponed
    among those adhering to the recommendations.</jats:p><jats:p>Results: After a
    median follow-up of 11 to 15 years across cohorts, 70,877 cancer cases were identified.
    Each one-point increase in the WCRF/AICR diet score [range, 0 (no) to 4 (complete
    adherence)] was significantly associated with a lower risk of total cancer [HR,
    0.94; 95% confidence interval (CI), 0.92–0.97], cancers of the colorectum (HR,
    0.84; 95% CI, 0.80–0.89) and prostate (HR, 0.94; 95% CI, 0.92–0.97), but not breast
    or lung. Adherence to an additional component of the WCRF/AICR diet score significantly
    postponed the incidence of cancer at any site by 1.6 years (RAP, −1.6; 95% CI,
    −4.09 to −2.16).</jats:p><jats:p>Conclusions: Adherence to WCRF/AICR dietary recommendations
    is associated with lower risk of cancer among older adults.</jats:p><jats:p>Impact:
    Dietary recommendations for cancer prevention are applicable to the elderly. Cancer
    Epidemiol Biomarkers Prev; 26(1); 136–44. ©2016 AACR.</jats:p>'
author:
- first_name: Nicole
  full_name: Jankovic, Nicole
  last_name: Jankovic
- first_name: Anouk
  full_name: Geelen, Anouk
  last_name: Geelen
- first_name: Renate M.
  full_name: Winkels, Renate M.
  last_name: Winkels
- first_name: Blaise
  full_name: Mwungura, Blaise
  last_name: Mwungura
- first_name: Veronika
  full_name: Fedirko, Veronika
  last_name: Fedirko
- first_name: Mazda
  full_name: Jenab, Mazda
  last_name: Jenab
- first_name: Anne K.
  full_name: Illner, Anne K.
  last_name: Illner
- first_name: Hermann
  full_name: Brenner, Hermann
  last_name: Brenner
- first_name: José M.
  full_name: Ordóñez-Mena, José M.
  last_name: Ordóñez-Mena
- first_name: Jessica C.
  full_name: Kiefte de Jong, Jessica C.
  last_name: Kiefte de Jong
- first_name: Oscar H.
  full_name: Franco, Oscar H.
  last_name: Franco
- first_name: Philippos
  full_name: Orfanos, Philippos
  last_name: Orfanos
- first_name: Antonia
  full_name: Trichopoulou, Antonia
  last_name: Trichopoulou
- first_name: Paolo
  full_name: Boffetta, Paolo
  last_name: Boffetta
- first_name: Antonio
  full_name: Agudo, Antonio
  last_name: Agudo
- first_name: Petra H.
  full_name: Peeters, Petra H.
  last_name: Peeters
- first_name: Anne
  full_name: Tjønneland, Anne
  last_name: Tjønneland
- first_name: Göran
  full_name: Hallmans, Göran
  last_name: Hallmans
- first_name: H. Bas
  full_name: Bueno-de-Mesquita, H. Bas
  last_name: Bueno-de-Mesquita
- first_name: Yikyung
  full_name: Park, Yikyung
  last_name: Park
- first_name: Edith J.
  full_name: Feskens, Edith J.
  last_name: Feskens
- first_name: Lisette C.
  full_name: de Groot, Lisette C.
  last_name: de Groot
- first_name: Ellen
  full_name: Kampman, Ellen
  last_name: Kampman
citation:
  ama: 'Jankovic N, Geelen A, Winkels RM, et al. Adherence to the WCRF/AICR Dietary
    Recommendations for Cancer Prevention and Risk of Cancer in Elderly from Europe
    and the United States: A Meta-Analysis within the CHANCES Project. <i>Cancer Epidemiology,
    Biomarkers &#38;amp; Prevention</i>. 2016;26(1):136-144. doi:<a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>'
  apa: 'Jankovic, N., Geelen, A., Winkels, R. M., Mwungura, B., Fedirko, V., Jenab,
    M., Illner, A. K., Brenner, H., Ordóñez-Mena, J. M., Kiefte de Jong, J. C., Franco,
    O. H., Orfanos, P., Trichopoulou, A., Boffetta, P., Agudo, A., Peeters, P. H.,
    Tjønneland, A., Hallmans, G., Bueno-de-Mesquita, H. B., … Kampman, E. (2016).
    Adherence to the WCRF/AICR Dietary Recommendations for Cancer Prevention and Risk
    of Cancer in Elderly from Europe and the United States: A Meta-Analysis within
    the CHANCES Project. <i>Cancer Epidemiology, Biomarkers &#38;amp; Prevention</i>,
    <i>26</i>(1), 136–144. <a href="https://doi.org/10.1158/1055-9965.epi-16-0428">https://doi.org/10.1158/1055-9965.epi-16-0428</a>'
  bibtex: '@article{Jankovic_Geelen_Winkels_Mwungura_Fedirko_Jenab_Illner_Brenner_Ordóñez-Mena_Kiefte
    de Jong_et al._2016, title={Adherence to the WCRF/AICR Dietary Recommendations
    for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United
    States: A Meta-Analysis within the CHANCES Project}, volume={26}, DOI={<a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>},
    number={1}, journal={Cancer Epidemiology, Biomarkers &#38;amp; Prevention}, publisher={American
    Association for Cancer Research (AACR)}, author={Jankovic, Nicole and Geelen,
    Anouk and Winkels, Renate M. and Mwungura, Blaise and Fedirko, Veronika and Jenab,
    Mazda and Illner, Anne K. and Brenner, Hermann and Ordóñez-Mena, José M. and Kiefte
    de Jong, Jessica C. and et al.}, year={2016}, pages={136–144} }'
  chicago: 'Jankovic, Nicole, Anouk Geelen, Renate M. Winkels, Blaise Mwungura, Veronika
    Fedirko, Mazda Jenab, Anne K. Illner, et al. “Adherence to the WCRF/AICR Dietary
    Recommendations for Cancer Prevention and Risk of Cancer in Elderly from Europe
    and the United States: A Meta-Analysis within the CHANCES Project.” <i>Cancer
    Epidemiology, Biomarkers &#38;amp; Prevention</i> 26, no. 1 (2016): 136–44. <a
    href="https://doi.org/10.1158/1055-9965.epi-16-0428">https://doi.org/10.1158/1055-9965.epi-16-0428</a>.'
  ieee: 'N. Jankovic <i>et al.</i>, “Adherence to the WCRF/AICR Dietary Recommendations
    for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United
    States: A Meta-Analysis within the CHANCES Project,” <i>Cancer Epidemiology, Biomarkers
    &#38;amp; Prevention</i>, vol. 26, no. 1, pp. 136–144, 2016, doi: <a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>.'
  mla: 'Jankovic, Nicole, et al. “Adherence to the WCRF/AICR Dietary Recommendations
    for Cancer Prevention and Risk of Cancer in Elderly from Europe and the United
    States: A Meta-Analysis within the CHANCES Project.” <i>Cancer Epidemiology, Biomarkers
    &#38;amp; Prevention</i>, vol. 26, no. 1, American Association for Cancer Research
    (AACR), 2016, pp. 136–44, doi:<a href="https://doi.org/10.1158/1055-9965.epi-16-0428">10.1158/1055-9965.epi-16-0428</a>.'
  short: N. Jankovic, A. Geelen, R.M. Winkels, B. Mwungura, V. Fedirko, M. Jenab,
    A.K. Illner, H. Brenner, J.M. Ordóñez-Mena, J.C. Kiefte de Jong, O.H. Franco,
    P. Orfanos, A. Trichopoulou, P. Boffetta, A. Agudo, P.H. Peeters, A. Tjønneland,
    G. Hallmans, H.B. Bueno-de-Mesquita, Y. Park, E.J. Feskens, L.C. de Groot, E.
    Kampman, Cancer Epidemiology, Biomarkers &#38;amp; Prevention 26 (2016) 136–144.
date_created: 2024-04-29T11:07:08Z
date_updated: 2024-06-17T09:01:44Z
doi: 10.1158/1055-9965.epi-16-0428
intvolume: '        26'
issue: '1'
language:
- iso: eng
page: 136-144
publication: Cancer Epidemiology, Biomarkers &amp; Prevention
publication_identifier:
  issn:
  - 1055-9965
  - 1538-7755
publication_status: published
publisher: American Association for Cancer Research (AACR)
status: public
title: 'Adherence to the WCRF/AICR Dietary Recommendations for Cancer Prevention and
  Risk of Cancer in Elderly from Europe and the United States: A Meta-Analysis within
  the CHANCES Project'
type: journal_article
user_id: '105192'
volume: 26
year: '2016'
...