[{"intvolume":"        35","date_updated":"2025-02-24T11:55:58Z","publication_status":"published","author":[{"full_name":"Hariz Belgacem, Khaled","first_name":"Khaled","last_name":"Hariz Belgacem"},{"full_name":"Jiménez, Fernando","last_name":"Jiménez","first_name":"Fernando"},{"full_name":"Ober-Blöbaum, Sina","last_name":"Ober-Blöbaum","first_name":"Sina"}],"publication_identifier":{"issn":["0938-8974","1432-1467"]},"year":"2025","title":"Fractional Variational Integrators Based on Convolution Quadrature","doi":"10.1007/s00332-025-10131-0","language":[{"iso":"eng"}],"article_number":"38","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title>\n          <jats:p>Fractional dissipation is a powerful tool to study nonlocal physical phenomena such as damping models. The design of geometric, in particular, variational integrators for the numerical simulation of such systems relies on a variational formulation of the model. In Jiménez and Ober-Blöbaum (J Nonlinear Sci 31:46, 2021), a new approach is proposed to deal with dissipative systems including fractionally damped systems in a variational way for both, the continuous and discrete setting. It is based on the doubling of variables and their fractional derivatives. The aim of this work is to derive higher-order fractional variational integrators by means of convolution quadrature (CQ) based on backward difference formulas. We then provide numerical methods that are of order 2 improving a previous result in Jiménez and Ober-Blöbaum (J Nonlinear Sci 31:46, 2021). The convergence properties of the fractional variational integrators and saturation effects due to the approximation of the fractional derivatives by CQ are studied numerically.</jats:p>"}],"issue":"2","publication":"Journal of Nonlinear Science","type":"journal_article","date_created":"2025-02-24T11:52:16Z","status":"public","volume":35,"user_id":"98857","_id":"58811","publisher":"Springer Science and Business Media LLC","citation":{"apa":"Hariz Belgacem, K., Jiménez, F., &#38; Ober-Blöbaum, S. (2025). Fractional Variational Integrators Based on Convolution Quadrature. <i>Journal of Nonlinear Science</i>, <i>35</i>(2), Article 38. <a href=\"https://doi.org/10.1007/s00332-025-10131-0\">https://doi.org/10.1007/s00332-025-10131-0</a>","ieee":"K. Hariz Belgacem, F. Jiménez, and S. Ober-Blöbaum, “Fractional Variational Integrators Based on Convolution Quadrature,” <i>Journal of Nonlinear Science</i>, vol. 35, no. 2, Art. no. 38, 2025, doi: <a href=\"https://doi.org/10.1007/s00332-025-10131-0\">10.1007/s00332-025-10131-0</a>.","short":"K. Hariz Belgacem, F. Jiménez, S. Ober-Blöbaum, Journal of Nonlinear Science 35 (2025).","chicago":"Hariz Belgacem, Khaled, Fernando Jiménez, and Sina Ober-Blöbaum. “Fractional Variational Integrators Based on Convolution Quadrature.” <i>Journal of Nonlinear Science</i> 35, no. 2 (2025). <a href=\"https://doi.org/10.1007/s00332-025-10131-0\">https://doi.org/10.1007/s00332-025-10131-0</a>.","mla":"Hariz Belgacem, Khaled, et al. “Fractional Variational Integrators Based on Convolution Quadrature.” <i>Journal of Nonlinear Science</i>, vol. 35, no. 2, 38, Springer Science and Business Media LLC, 2025, doi:<a href=\"https://doi.org/10.1007/s00332-025-10131-0\">10.1007/s00332-025-10131-0</a>.","ama":"Hariz Belgacem K, Jiménez F, Ober-Blöbaum S. Fractional Variational Integrators Based on Convolution Quadrature. <i>Journal of Nonlinear Science</i>. 2025;35(2). doi:<a href=\"https://doi.org/10.1007/s00332-025-10131-0\">10.1007/s00332-025-10131-0</a>","bibtex":"@article{Hariz Belgacem_Jiménez_Ober-Blöbaum_2025, title={Fractional Variational Integrators Based on Convolution Quadrature}, volume={35}, DOI={<a href=\"https://doi.org/10.1007/s00332-025-10131-0\">10.1007/s00332-025-10131-0</a>}, number={238}, journal={Journal of Nonlinear Science}, publisher={Springer Science and Business Media LLC}, author={Hariz Belgacem, Khaled and Jiménez, Fernando and Ober-Blöbaum, Sina}, year={2025} }"}},{"citation":{"chicago":"Evje, Steinar, and Michael Winkler. “Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow.” <i>Journal of Nonlinear Science</i> 30, no. 4 (2020): 1809–47. <a href=\"https://doi.org/10.1007/s00332-020-09625-w\">https://doi.org/10.1007/s00332-020-09625-w</a>.","short":"S. Evje, M. Winkler, Journal of Nonlinear Science 30 (2020) 1809–1847.","apa":"Evje, S., &#38; Winkler, M. (2020). Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow. <i>Journal of Nonlinear Science</i>, <i>30</i>(4), 1809–1847. <a href=\"https://doi.org/10.1007/s00332-020-09625-w\">https://doi.org/10.1007/s00332-020-09625-w</a>","ieee":"S. Evje and M. Winkler, “Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow,” <i>Journal of Nonlinear Science</i>, vol. 30, no. 4, pp. 1809–1847, 2020, doi: <a href=\"https://doi.org/10.1007/s00332-020-09625-w\">10.1007/s00332-020-09625-w</a>.","ama":"Evje S, Winkler M. Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow. <i>Journal of Nonlinear Science</i>. 2020;30(4):1809-1847. doi:<a href=\"https://doi.org/10.1007/s00332-020-09625-w\">10.1007/s00332-020-09625-w</a>","bibtex":"@article{Evje_Winkler_2020, title={Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow}, volume={30}, DOI={<a href=\"https://doi.org/10.1007/s00332-020-09625-w\">10.1007/s00332-020-09625-w</a>}, number={4}, journal={Journal of Nonlinear Science}, publisher={Springer Science and Business Media LLC}, author={Evje, Steinar and Winkler, Michael}, year={2020}, pages={1809–1847} }","mla":"Evje, Steinar, and Michael Winkler. “Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow.” <i>Journal of Nonlinear Science</i>, vol. 30, no. 4, Springer Science and Business Media LLC, 2020, pp. 1809–47, doi:<a href=\"https://doi.org/10.1007/s00332-020-09625-w\">10.1007/s00332-020-09625-w</a>."},"volume":30,"user_id":"31496","_id":"63329","publisher":"Springer Science and Business Media LLC","page":"1809-1847","status":"public","type":"journal_article","date_created":"2025-12-18T19:38:02Z","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:p>Recent experimental work has revealed that interstitial fluid flow can mobilize two types of tumor cell migration mechanisms. One is a chemotactic-driven mechanism where chemokine (chemical component) bounded to the extracellular matrix (ECM) is released and skewed in the flow direction. This leads to higher chemical concentrations downstream which the tumor cells can sense and migrate toward. The other is a mechanism where the flowing fluid imposes a stress on the tumor cells which triggers them to go in the upstream direction. Researchers have suggested that these two migration modes possibly can play a role in metastatic behavior, i.e., the process where tumor cells are able to break loose from the primary tumor and move to nearby lymphatic vessels. In Waldeland and Evje (J Biomech 81:22–35, 2018), a mathematical cell–fluid model was put forward based on a mixture theory formulation. It was demonstrated that the model was able to capture the main characteristics of the two competing migration mechanisms. The objective of the current work is to seek deeper insight into certain qualitative aspects of these competing mechanisms by means of mathematical methods. For that purpose, we propose a simpler version of the cell–fluid model mentioned above but such that the two competing migration mechanisms are retained. An initial cell distribution in a one-dimensional slab is exposed to a constant fluid flow from one end to the other, consistent with the experimental setup. Then, we explore by means of analytical estimates the long-time behavior of the two competing migration mechanisms for two different scenarios: (i) when the initial cell volume fraction is low and (ii) when the initial cell volume fraction is high. In particular, it is demonstrated in a strict mathematical sense that for a sufficiently low initial cell volume fraction, the downstream migration dominates in the sense that the solution converges to a downstream-dominated steady state as time elapses. On the other hand, with a sufficiently high initial cell volume fraction, the upstream migration mechanism is the stronger in the sense that the solution converges to an upstream-dominated steady state.\r\n</jats:p>"}],"issue":"4","publication":"Journal of Nonlinear Science","doi":"10.1007/s00332-020-09625-w","language":[{"iso":"eng"}],"intvolume":"        30","date_updated":"2025-12-18T20:00:26Z","publication_status":"published","publication_identifier":{"issn":["0938-8974","1432-1467"]},"author":[{"last_name":"Evje","first_name":"Steinar","full_name":"Evje, Steinar"},{"full_name":"Winkler, Michael","last_name":"Winkler","first_name":"Michael","id":"31496"}],"title":"Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow","year":"2020"},{"year":"2018","status":"public","title":"Data-Driven Model Reduction and Transfer Operator Approximation","author":[{"full_name":"Klus, Stefan","last_name":"Klus","first_name":"Stefan"},{"full_name":"Nüske, Feliks","last_name":"Nüske","first_name":"Feliks","orcid":"0000-0003-2444-7889","id":"81513"},{"last_name":"Koltai","first_name":"Péter","full_name":"Koltai, Péter"},{"full_name":"Wu, Hao","first_name":"Hao","last_name":"Wu"},{"last_name":"Kevrekidis","first_name":"Ioannis","full_name":"Kevrekidis, Ioannis"},{"first_name":"Christof","last_name":"Schütte","full_name":"Schütte, Christof"},{"first_name":"Frank","last_name":"Noé","full_name":"Noé, Frank"}],"publication_identifier":{"issn":["0938-8974","1432-1467"]},"publication_status":"published","date_updated":"2022-01-06T06:55:20Z","page":"985-1010","_id":"21941","language":[{"iso":"eng"}],"user_id":"81513","doi":"10.1007/s00332-017-9437-7","publication":"Journal of Nonlinear Science","citation":{"mla":"Klus, Stefan, et al. “Data-Driven Model Reduction and Transfer Operator Approximation.” <i>Journal of Nonlinear Science</i>, 2018, pp. 985–1010, doi:<a href=\"https://doi.org/10.1007/s00332-017-9437-7\">10.1007/s00332-017-9437-7</a>.","bibtex":"@article{Klus_Nüske_Koltai_Wu_Kevrekidis_Schütte_Noé_2018, title={Data-Driven Model Reduction and Transfer Operator Approximation}, DOI={<a href=\"https://doi.org/10.1007/s00332-017-9437-7\">10.1007/s00332-017-9437-7</a>}, journal={Journal of Nonlinear Science}, author={Klus, Stefan and Nüske, Feliks and Koltai, Péter and Wu, Hao and Kevrekidis, Ioannis and Schütte, Christof and Noé, Frank}, year={2018}, pages={985–1010} }","ama":"Klus S, Nüske F, Koltai P, et al. Data-Driven Model Reduction and Transfer Operator Approximation. <i>Journal of Nonlinear Science</i>. 2018:985-1010. doi:<a href=\"https://doi.org/10.1007/s00332-017-9437-7\">10.1007/s00332-017-9437-7</a>","ieee":"S. Klus <i>et al.</i>, “Data-Driven Model Reduction and Transfer Operator Approximation,” <i>Journal of Nonlinear Science</i>, pp. 985–1010, 2018.","apa":"Klus, S., Nüske, F., Koltai, P., Wu, H., Kevrekidis, I., Schütte, C., &#38; Noé, F. (2018). Data-Driven Model Reduction and Transfer Operator Approximation. <i>Journal of Nonlinear Science</i>, 985–1010. <a href=\"https://doi.org/10.1007/s00332-017-9437-7\">https://doi.org/10.1007/s00332-017-9437-7</a>","short":"S. Klus, F. Nüske, P. Koltai, H. Wu, I. Kevrekidis, C. Schütte, F. Noé, Journal of Nonlinear Science (2018) 985–1010.","chicago":"Klus, Stefan, Feliks Nüske, Péter Koltai, Hao Wu, Ioannis Kevrekidis, Christof Schütte, and Frank Noé. “Data-Driven Model Reduction and Transfer Operator Approximation.” <i>Journal of Nonlinear Science</i>, 2018, 985–1010. <a href=\"https://doi.org/10.1007/s00332-017-9437-7\">https://doi.org/10.1007/s00332-017-9437-7</a>."},"extern":"1","date_created":"2021-04-30T16:59:03Z","type":"journal_article","department":[{"_id":"101"}]},{"doi":"10.1007/s00332-017-9415-0","user_id":"47427","volume":28,"page":"471-512","_id":"16715","language":[{"iso":"eng"}],"date_updated":"2022-01-06T06:52:55Z","publication_status":"published","intvolume":"        28","year":"2018","status":"public","title":"Transition Manifolds of Complex Metastable Systems","publication_identifier":{"issn":["0938-8974","1432-1467"]},"author":[{"first_name":"Andreas","last_name":"Bittracher","full_name":"Bittracher, Andreas"},{"last_name":"Koltai","first_name":"Péter","full_name":"Koltai, Péter"},{"full_name":"Klus, Stefan","last_name":"Klus","first_name":"Stefan"},{"first_name":"Ralf","last_name":"Banisch","full_name":"Banisch, Ralf"},{"full_name":"Dellnitz, Michael","last_name":"Dellnitz","first_name":"Michael"},{"last_name":"Schütte","first_name":"Christof","full_name":"Schütte, Christof"}],"type":"journal_article","department":[{"_id":"101"}],"date_created":"2020-04-16T14:09:31Z","publication":"Journal of Nonlinear Science","citation":{"chicago":"Bittracher, Andreas, Péter Koltai, Stefan Klus, Ralf Banisch, Michael Dellnitz, and Christof Schütte. “Transition Manifolds of Complex Metastable Systems.” <i>Journal of Nonlinear Science</i> 28 (2018): 471–512. <a href=\"https://doi.org/10.1007/s00332-017-9415-0\">https://doi.org/10.1007/s00332-017-9415-0</a>.","ama":"Bittracher A, Koltai P, Klus S, Banisch R, Dellnitz M, Schütte C. Transition Manifolds of Complex Metastable Systems. <i>Journal of Nonlinear Science</i>. 2018;28:471-512. doi:<a href=\"https://doi.org/10.1007/s00332-017-9415-0\">10.1007/s00332-017-9415-0</a>","short":"A. Bittracher, P. Koltai, S. Klus, R. Banisch, M. Dellnitz, C. Schütte, Journal of Nonlinear Science 28 (2018) 471–512.","bibtex":"@article{Bittracher_Koltai_Klus_Banisch_Dellnitz_Schütte_2018, title={Transition Manifolds of Complex Metastable Systems}, volume={28}, DOI={<a href=\"https://doi.org/10.1007/s00332-017-9415-0\">10.1007/s00332-017-9415-0</a>}, journal={Journal of Nonlinear Science}, author={Bittracher, Andreas and Koltai, Péter and Klus, Stefan and Banisch, Ralf and Dellnitz, Michael and Schütte, Christof}, year={2018}, pages={471–512} }","apa":"Bittracher, A., Koltai, P., Klus, S., Banisch, R., Dellnitz, M., &#38; Schütte, C. (2018). Transition Manifolds of Complex Metastable Systems. <i>Journal of Nonlinear Science</i>, <i>28</i>, 471–512. <a href=\"https://doi.org/10.1007/s00332-017-9415-0\">https://doi.org/10.1007/s00332-017-9415-0</a>","mla":"Bittracher, Andreas, et al. “Transition Manifolds of Complex Metastable Systems.” <i>Journal of Nonlinear Science</i>, vol. 28, 2018, pp. 471–512, doi:<a href=\"https://doi.org/10.1007/s00332-017-9415-0\">10.1007/s00332-017-9415-0</a>.","ieee":"A. Bittracher, P. Koltai, S. Klus, R. Banisch, M. Dellnitz, and C. Schütte, “Transition Manifolds of Complex Metastable Systems,” <i>Journal of Nonlinear Science</i>, vol. 28, pp. 471–512, 2018."}},{"date_created":"2020-04-16T05:53:07Z","type":"journal_article","department":[{"_id":"101"}],"publication":"Journal of Nonlinear Science","citation":{"mla":"Flaßkamp, Kathrin, et al. “Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures.” <i>Journal of Nonlinear Science</i>, 2012, pp. 599–629, doi:<a href=\"https://doi.org/10.1007/s00332-012-9140-7\">10.1007/s00332-012-9140-7</a>.","bibtex":"@article{Flaßkamp_Ober-Blöbaum_Kobilarov_2012, title={Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures}, DOI={<a href=\"https://doi.org/10.1007/s00332-012-9140-7\">10.1007/s00332-012-9140-7</a>}, journal={Journal of Nonlinear Science}, author={Flaßkamp, Kathrin and Ober-Blöbaum, Sina and Kobilarov, Marin}, year={2012}, pages={599–629} }","ama":"Flaßkamp K, Ober-Blöbaum S, Kobilarov M. Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures. <i>Journal of Nonlinear Science</i>. 2012:599-629. doi:<a href=\"https://doi.org/10.1007/s00332-012-9140-7\">10.1007/s00332-012-9140-7</a>","ieee":"K. Flaßkamp, S. Ober-Blöbaum, and M. Kobilarov, “Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures,” <i>Journal of Nonlinear Science</i>, pp. 599–629, 2012.","apa":"Flaßkamp, K., Ober-Blöbaum, S., &#38; Kobilarov, M. (2012). Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures. <i>Journal of Nonlinear Science</i>, 599–629. <a href=\"https://doi.org/10.1007/s00332-012-9140-7\">https://doi.org/10.1007/s00332-012-9140-7</a>","short":"K. Flaßkamp, S. Ober-Blöbaum, M. Kobilarov, Journal of Nonlinear Science (2012) 599–629.","chicago":"Flaßkamp, Kathrin, Sina Ober-Blöbaum, and Marin Kobilarov. “Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures.” <i>Journal of Nonlinear Science</i>, 2012, 599–629. <a href=\"https://doi.org/10.1007/s00332-012-9140-7\">https://doi.org/10.1007/s00332-012-9140-7</a>."},"page":"599-629","_id":"16592","language":[{"iso":"eng"}],"user_id":"15701","doi":"10.1007/s00332-012-9140-7","status":"public","title":"Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures","year":"2012","publication_identifier":{"issn":["0938-8974","1432-1467"]},"author":[{"full_name":"Flaßkamp, Kathrin","last_name":"Flaßkamp","first_name":"Kathrin"},{"full_name":"Ober-Blöbaum, Sina","first_name":"Sina","last_name":"Ober-Blöbaum"},{"first_name":"Marin","last_name":"Kobilarov","full_name":"Kobilarov, Marin"}],"publication_status":"published","date_updated":"2022-01-06T06:52:52Z"}]