---
_id: '26523'
abstract:
- lang: eng
text: AbstractWith this case report we support
our medical hypothesis that metreleptin treatment ameliorates starvation related
emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and
show for the first time strong effects in a male patient with AN. A 15.9 year
old adolescent with severe AN of eight-month duration was treated off-label with
metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales
(VAS), validated self- and clinician rating scales and lab results tracked changes
from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial
improvements of mood and eating disorder related cognitions and hyperactivity
set in after two days of treatment. During dosing, sub-physiological testosterone
and TT3 levels normalized; clinically libido reemerged. Weight did not increase
substantially during the dosing period. During follow-up target weight was attained;
mood did not deteriorate; hyperactivity ceased. The results substantiate the strong
effects seen in female cases and underscore the need for a double-blind placebo-controlled
trial to confirm the observed strong, multiple and rapid onset beneficial effects
of metreleptin in AN.
author:
- first_name: Jochen
full_name: Antel, Jochen
last_name: Antel
- first_name: Susanne
full_name: Tan, Susanne
last_name: Tan
- first_name: Marvin
full_name: Grabler, Marvin
last_name: Grabler
- first_name: Christine
full_name: Ludwig, Christine
last_name: Ludwig
- first_name: Dominik
full_name: Lohkemper, Dominik
last_name: Lohkemper
- first_name: Tim
full_name: Brandenburg, Tim
last_name: Brandenburg
- first_name: Nikolaus
full_name: Barth, Nikolaus
last_name: Barth
- first_name: Anke
full_name: Hinney, Anke
last_name: Hinney
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
- first_name: Miriam
full_name: Remy, Miriam
last_name: Remy
- first_name: Gabriella
full_name: Milos, Gabriella
last_name: Milos
- first_name: Johannes
full_name: Hebebrand, Johannes
last_name: Hebebrand
citation:
ama: Antel J, Tan S, Grabler M, et al. Rapid amelioration of anorexia nervosa in
a male adolescent during metreleptin treatment including recovery from hypogonadotropic
hypogonadism. European Child & Adolescent Psychiatry. Published online
2021. doi:10.1007/s00787-021-01778-7
apa: Antel, J., Tan, S., Grabler, M., Ludwig, C., Lohkemper, D., Brandenburg, T.,
Barth, N., Hinney, A., Libuda, L., Remy, M., Milos, G., & Hebebrand, J. (2021).
Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin
treatment including recovery from hypogonadotropic hypogonadism. European Child
& Adolescent Psychiatry. https://doi.org/10.1007/s00787-021-01778-7
bibtex: '@article{Antel_Tan_Grabler_Ludwig_Lohkemper_Brandenburg_Barth_Hinney_Libuda_Remy_et
al._2021, title={Rapid amelioration of anorexia nervosa in a male adolescent during
metreleptin treatment including recovery from hypogonadotropic hypogonadism},
DOI={10.1007/s00787-021-01778-7},
journal={European Child & Adolescent Psychiatry}, author={Antel, Jochen and
Tan, Susanne and Grabler, Marvin and Ludwig, Christine and Lohkemper, Dominik
and Brandenburg, Tim and Barth, Nikolaus and Hinney, Anke and Libuda, Lars and
Remy, Miriam and et al.}, year={2021} }'
chicago: Antel, Jochen, Susanne Tan, Marvin Grabler, Christine Ludwig, Dominik Lohkemper,
Tim Brandenburg, Nikolaus Barth, et al. “Rapid Amelioration of Anorexia Nervosa
in a Male Adolescent during Metreleptin Treatment Including Recovery from Hypogonadotropic
Hypogonadism.” European Child & Adolescent Psychiatry, 2021. https://doi.org/10.1007/s00787-021-01778-7.
ieee: 'J. Antel et al., “Rapid amelioration of anorexia nervosa in a male
adolescent during metreleptin treatment including recovery from hypogonadotropic
hypogonadism,” European Child & Adolescent Psychiatry, 2021, doi: 10.1007/s00787-021-01778-7.'
mla: Antel, Jochen, et al. “Rapid Amelioration of Anorexia Nervosa in a Male Adolescent
during Metreleptin Treatment Including Recovery from Hypogonadotropic Hypogonadism.”
European Child & Adolescent Psychiatry, 2021, doi:10.1007/s00787-021-01778-7.
short: J. Antel, S. Tan, M. Grabler, C. Ludwig, D. Lohkemper, T. Brandenburg, N.
Barth, A. Hinney, L. Libuda, M. Remy, G. Milos, J. Hebebrand, European Child &
Adolescent Psychiatry (2021).
date_created: 2021-10-19T09:53:53Z
date_updated: 2022-01-06T06:57:21Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.1007/s00787-021-01778-7
language:
- iso: eng
publication: European Child & Adolescent Psychiatry
publication_identifier:
issn:
- 1018-8827
- 1435-165X
publication_status: published
status: public
title: Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin
treatment including recovery from hypogonadotropic hypogonadism
type: journal_article
user_id: '49428'
year: '2021'
...
---
_id: '27522'
author:
- first_name: Manuel
full_name: Föcker, Manuel
last_name: Föcker
- first_name: Jochen
full_name: Antel, Jochen
last_name: Antel
- first_name: Stefanie
full_name: Ring, Stefanie
last_name: Ring
- first_name: Denise
full_name: Hahn, Denise
last_name: Hahn
- first_name: Özlem
full_name: Kanal, Özlem
last_name: Kanal
- first_name: Dana
full_name: Öztürk, Dana
last_name: Öztürk
- first_name: Johannes
full_name: Hebebrand, Johannes
last_name: Hebebrand
- first_name: Lars
full_name: Libuda, Lars
id: '88682'
last_name: Libuda
orcid: 0000-0003-1603-3133
citation:
ama: Föcker M, Antel J, Ring S, et al. Vitamin D and mental health in children and
adolescents. European Child & Adolescent Psychiatry. Published online
2017:1043-1066. doi:10.1007/s00787-017-0949-3
apa: Föcker, M., Antel, J., Ring, S., Hahn, D., Kanal, Ö., Öztürk, D., Hebebrand,
J., & Libuda, L. (2017). Vitamin D and mental health in children and adolescents.
European Child & Adolescent Psychiatry, 1043–1066. https://doi.org/10.1007/s00787-017-0949-3
bibtex: '@article{Föcker_Antel_Ring_Hahn_Kanal_Öztürk_Hebebrand_Libuda_2017, title={Vitamin
D and mental health in children and adolescents}, DOI={10.1007/s00787-017-0949-3},
journal={European Child & Adolescent Psychiatry}, author={Föcker, Manuel and
Antel, Jochen and Ring, Stefanie and Hahn, Denise and Kanal, Özlem and Öztürk,
Dana and Hebebrand, Johannes and Libuda, Lars}, year={2017}, pages={1043–1066}
}'
chicago: Föcker, Manuel, Jochen Antel, Stefanie Ring, Denise Hahn, Özlem Kanal,
Dana Öztürk, Johannes Hebebrand, and Lars Libuda. “Vitamin D and Mental Health
in Children and Adolescents.” European Child & Adolescent Psychiatry,
2017, 1043–66. https://doi.org/10.1007/s00787-017-0949-3.
ieee: 'M. Föcker et al., “Vitamin D and mental health in children and adolescents,”
European Child & Adolescent Psychiatry, pp. 1043–1066, 2017, doi: 10.1007/s00787-017-0949-3.'
mla: Föcker, Manuel, et al. “Vitamin D and Mental Health in Children and Adolescents.”
European Child & Adolescent Psychiatry, 2017, pp. 1043–66, doi:10.1007/s00787-017-0949-3.
short: M. Föcker, J. Antel, S. Ring, D. Hahn, Ö. Kanal, D. Öztürk, J. Hebebrand,
L. Libuda, European Child & Adolescent Psychiatry (2017) 1043–1066.
date_created: 2021-11-17T11:04:55Z
date_updated: 2022-01-06T06:57:40Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.1007/s00787-017-0949-3
language:
- iso: eng
page: 1043-1066
publication: European Child & Adolescent Psychiatry
publication_identifier:
issn:
- 1018-8827
- 1435-165X
publication_status: published
status: public
title: Vitamin D and mental health in children and adolescents
type: journal_article
user_id: '49428'
year: '2017'
...