@article{59511,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>To minimize or avoid the use of antibiotics, antimicrobial polymers have emerged as a promising option to fight biomaterial‐associated infections, e.g., on titanium‐based implants. However, the challenge is to develop active polymers that exhibit an antimicrobial effect and are compatible with human cells. Different studies aiming for biocidal polymers active in soluble mode, focused on the ratio of cationic to hydrophobic groups, while only marginal knowledge is available for immobilized components. Here a strong hydrophilic electrolyte 4‐vinylbenzyltrimethylammonium chloride (TMA) is chosen as the cationic component. The block composition of the polycationic segment is modified with styrene (Sty) regarding the amphiphilic balance. To adsorb such polymers onto titanium surfaces they are equipped with a polyphosphonic acid anchor block by sequential reversible‐addition‐fragmentation chain‐transfer polymerization (RAFT) polymerization. The polymer composition affected the wetting behavior of adsorbed coatings with water contact angles ranging from 17° to 72°, while zetapotential measurements confirmed high extent of positive charges for all adsorbed polymer coatings. The fundamentally modified block composition resulted in significantly improved cytocompatibility. Antimicrobial efficacy in early bacterial adhesion is still retained from slightly antiadhesive coatings to combined antiadhesive/biocidal activity depending on Sty/TMA ratio in random polymers while a block copolymer revealed lowest antimicrobial effect.</jats:p>}},
  author       = {{Wolf‐Brandstetter, Cornelia and Methling, Rafael and Kuckling, Dirk}},
  issn         = {{1438-7492}},
  journal      = {{Macromolecular Materials and Engineering}},
  keywords     = {{antiadhesive surfaces, antimicrobial polymers, grafting to, polymerbrushes}},
  publisher    = {{Wiley}},
  title        = {{{Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility}}},
  doi          = {{10.1002/mame.202500078}},
  year         = {{2025}},
}

@article{53170,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>Coating medical implants with antibacterial polymers may prevent postoperative infections which are a common issue for conventional titanium implants and can even lead to implant failure. Easily applicable diblock copolymers are presented that form polymer brushes via “grafting to” mechanism on titanium and equip the modified material with antibacterial properties. The polymers carry quaternized pyridinium units to combat bacteria and phosphonic acid groups which allow the linear chains to be anchored to metal surfaces in a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy and SEC. Low grafting densities are a major drawback of the “grafting to” approach compared to “grafting from”. Thus, the number of phosphonic acid groups in the anchor block are varied to investigate and optimize the surface binding. Modified titanium surfaces are examined regarding their composition, wetting behavior, streaming potential, and coating stability. Evaluation of the antimicrobial properties revealed reduced bacterial adhesion and biofilm formation for certain polymers, albeit the cell biocompatibility against human gingival fibroblasts is also impaired. The presented findings show the potential of easy‐to‐apply polymer coatings and aid in designing next‐generation implant surface modifications.</jats:p>}},
  author       = {{Methling, Rafael and Dückmann, Oliver and Simon, Frank and Wolf‐Brandstetter, Cornelia and Kuckling, Dirk}},
  issn         = {{1438-7492}},
  journal      = {{Macromolecular Materials and Engineering}},
  keywords     = {{Materials Chemistry, Polymers and Plastics, Organic Chemistry, General Chemical Engineering}},
  number       = {{8}},
  publisher    = {{Wiley}},
  title        = {{{Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers}}},
  doi          = {{10.1002/mame.202200665}},
  volume       = {{308}},
  year         = {{2023}},
}

@article{25309,
  author       = {{Ruediger, Arne A. and Bremser, Wolfgang and Strube, Oliver I.}},
  issn         = {{1438-7492}},
  journal      = {{Macromolecular Materials and Engineering}},
  pages        = {{1181--1190}},
  title        = {{{Nanoscaled Biocoatings via Enzyme Mediated Autodeposition of Casein}}},
  doi          = {{10.1002/mame.201600034}},
  year         = {{2016}},
}

@article{25311,
  author       = {{Strube, Oliver I. and Büngeler, Anne and Bremser, Wolfgang}},
  issn         = {{1438-7492}},
  journal      = {{Macromolecular Materials and Engineering}},
  pages        = {{801--804}},
  title        = {{{Enzyme-Mediated In Situ Synthesis and Deposition of Nonaggregated Melanin Protoparticles}}},
  doi          = {{10.1002/mame.201500315}},
  year         = {{2016}},
}