---
_id: '59511'
abstract:
- lang: eng
text: AbstractTo minimize or avoid the use of antibiotics,
antimicrobial polymers have emerged as a promising option to fight biomaterial‐associated
infections, e.g., on titanium‐based implants. However, the challenge is to develop
active polymers that exhibit an antimicrobial effect and are compatible with human
cells. Different studies aiming for biocidal polymers active in soluble mode,
focused on the ratio of cationic to hydrophobic groups, while only marginal knowledge
is available for immobilized components. Here a strong hydrophilic electrolyte
4‐vinylbenzyltrimethylammonium chloride (TMA) is chosen as the cationic component.
The block composition of the polycationic segment is modified with styrene (Sty)
regarding the amphiphilic balance. To adsorb such polymers onto titanium surfaces
they are equipped with a polyphosphonic acid anchor block by sequential reversible‐addition‐fragmentation
chain‐transfer polymerization (RAFT) polymerization. The polymer composition affected
the wetting behavior of adsorbed coatings with water contact angles ranging from
17° to 72°, while zetapotential measurements confirmed high extent of positive
charges for all adsorbed polymer coatings. The fundamentally modified block composition
resulted in significantly improved cytocompatibility. Antimicrobial efficacy in
early bacterial adhesion is still retained from slightly antiadhesive coatings
to combined antiadhesive/biocidal activity depending on Sty/TMA ratio in random
polymers while a block copolymer revealed lowest antimicrobial effect.
author:
- first_name: Cornelia
full_name: Wolf‐Brandstetter, Cornelia
last_name: Wolf‐Brandstetter
- first_name: Rafael
full_name: Methling, Rafael
last_name: Methling
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Wolf‐Brandstetter C, Methling R, Kuckling D. Adsorbable and Antimicrobial Amphiphilic
Block Copolymers with Enhanced Biocompatibility. Macromolecular Materials and
Engineering. Published online 2025. doi:10.1002/mame.202500078
apa: Wolf‐Brandstetter, C., Methling, R., & Kuckling, D. (2025). Adsorbable
and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.
Macromolecular Materials and Engineering. https://doi.org/10.1002/mame.202500078
bibtex: '@article{Wolf‐Brandstetter_Methling_Kuckling_2025, title={Adsorbable and
Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility}, DOI={10.1002/mame.202500078}, journal={Macromolecular
Materials and Engineering}, publisher={Wiley}, author={Wolf‐Brandstetter, Cornelia
and Methling, Rafael and Kuckling, Dirk}, year={2025} }'
chicago: Wolf‐Brandstetter, Cornelia, Rafael Methling, and Dirk Kuckling. “Adsorbable
and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.”
Macromolecular Materials and Engineering, 2025. https://doi.org/10.1002/mame.202500078.
ieee: 'C. Wolf‐Brandstetter, R. Methling, and D. Kuckling, “Adsorbable and Antimicrobial
Amphiphilic Block Copolymers with Enhanced Biocompatibility,” Macromolecular
Materials and Engineering, 2025, doi: 10.1002/mame.202500078.'
mla: Wolf‐Brandstetter, Cornelia, et al. “Adsorbable and Antimicrobial Amphiphilic
Block Copolymers with Enhanced Biocompatibility.” Macromolecular Materials
and Engineering, Wiley, 2025, doi:10.1002/mame.202500078.
short: C. Wolf‐Brandstetter, R. Methling, D. Kuckling, Macromolecular Materials
and Engineering (2025).
date_created: 2025-04-11T07:35:39Z
date_updated: 2025-04-11T07:43:06Z
department:
- _id: '163'
doi: 10.1002/mame.202500078
keyword:
- antiadhesive surfaces
- antimicrobial polymers
- grafting to
- polymerbrushes
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500078
publication: Macromolecular Materials and Engineering
publication_identifier:
issn:
- 1438-7492
- 1439-2054
publication_status: published
publisher: Wiley
status: public
title: Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility
type: journal_article
user_id: '94'
year: '2025'
...
---
_id: '53170'
abstract:
- lang: eng
text: AbstractCoating medical implants with antibacterial
polymers may prevent postoperative infections which are a common issue for conventional
titanium implants and can even lead to implant failure. Easily applicable diblock
copolymers are presented that form polymer brushes via “grafting to” mechanism
on titanium and equip the modified material with antibacterial properties. The
polymers carry quaternized pyridinium units to combat bacteria and phosphonic
acid groups which allow the linear chains to be anchored to metal surfaces in
a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer
(RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy
and SEC. Low grafting densities are a major drawback of the “grafting to” approach
compared to “grafting from”. Thus, the number of phosphonic acid groups in the
anchor block are varied to investigate and optimize the surface binding. Modified
titanium surfaces are examined regarding their composition, wetting behavior,
streaming potential, and coating stability. Evaluation of the antimicrobial properties
revealed reduced bacterial adhesion and biofilm formation for certain polymers,
albeit the cell biocompatibility against human gingival fibroblasts is also impaired.
The presented findings show the potential of easy‐to‐apply polymer coatings and
aid in designing next‐generation implant surface modifications.
article_type: original
author:
- first_name: Rafael
full_name: Methling, Rafael
last_name: Methling
- first_name: Oliver
full_name: Dückmann, Oliver
last_name: Dückmann
- first_name: Frank
full_name: Simon, Frank
last_name: Simon
- first_name: Cornelia
full_name: Wolf‐Brandstetter, Cornelia
last_name: Wolf‐Brandstetter
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Methling R, Dückmann O, Simon F, Wolf‐Brandstetter C, Kuckling D. Antimicrobial
Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing
Block Copolymers. Macromolecular Materials and Engineering. 2023;308(8).
doi:10.1002/mame.202200665
apa: Methling, R., Dückmann, O., Simon, F., Wolf‐Brandstetter, C., & Kuckling,
D. (2023). Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic
Acid/Pyridinium Containing Block Copolymers. Macromolecular Materials and Engineering,
308(8). https://doi.org/10.1002/mame.202200665
bibtex: '@article{Methling_Dückmann_Simon_Wolf‐Brandstetter_Kuckling_2023, title={Antimicrobial
Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing
Block Copolymers}, volume={308}, DOI={10.1002/mame.202200665},
number={8}, journal={Macromolecular Materials and Engineering}, publisher={Wiley},
author={Methling, Rafael and Dückmann, Oliver and Simon, Frank and Wolf‐Brandstetter,
Cornelia and Kuckling, Dirk}, year={2023} }'
chicago: Methling, Rafael, Oliver Dückmann, Frank Simon, Cornelia Wolf‐Brandstetter,
and Dirk Kuckling. “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using
Phosphonic Acid/Pyridinium Containing Block Copolymers.” Macromolecular Materials
and Engineering 308, no. 8 (2023). https://doi.org/10.1002/mame.202200665.
ieee: 'R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, and D. Kuckling,
“Antimicrobial Brushes on Titanium via ‘Grafting to’ Using Phosphonic Acid/Pyridinium
Containing Block Copolymers,” Macromolecular Materials and Engineering,
vol. 308, no. 8, 2023, doi: 10.1002/mame.202200665.'
mla: Methling, Rafael, et al. “Antimicrobial Brushes on Titanium via ‘Grafting to’
Using Phosphonic Acid/Pyridinium Containing Block Copolymers.” Macromolecular
Materials and Engineering, vol. 308, no. 8, Wiley, 2023, doi:10.1002/mame.202200665.
short: R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, D. Kuckling, Macromolecular
Materials and Engineering 308 (2023).
date_created: 2024-04-03T11:08:51Z
date_updated: 2024-04-03T11:10:05Z
department:
- _id: '163'
doi: 10.1002/mame.202200665
intvolume: ' 308'
issue: '8'
keyword:
- Materials Chemistry
- Polymers and Plastics
- Organic Chemistry
- General Chemical Engineering
language:
- iso: eng
publication: Macromolecular Materials and Engineering
publication_identifier:
issn:
- 1438-7492
- 1439-2054
publication_status: published
publisher: Wiley
status: public
title: Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium
Containing Block Copolymers
type: journal_article
user_id: '94'
volume: 308
year: '2023'
...
---
_id: '25309'
author:
- first_name: Arne A.
full_name: Ruediger, Arne A.
last_name: Ruediger
- first_name: Wolfgang
full_name: Bremser, Wolfgang
last_name: Bremser
- first_name: Oliver I.
full_name: Strube, Oliver I.
last_name: Strube
citation:
ama: Ruediger AA, Bremser W, Strube OI. Nanoscaled Biocoatings via Enzyme Mediated
Autodeposition of Casein. Macromolecular Materials and Engineering. Published
online 2016:1181-1190. doi:10.1002/mame.201600034
apa: Ruediger, A. A., Bremser, W., & Strube, O. I. (2016). Nanoscaled Biocoatings
via Enzyme Mediated Autodeposition of Casein. Macromolecular Materials and
Engineering, 1181–1190. https://doi.org/10.1002/mame.201600034
bibtex: '@article{Ruediger_Bremser_Strube_2016, title={Nanoscaled Biocoatings via
Enzyme Mediated Autodeposition of Casein}, DOI={10.1002/mame.201600034},
journal={Macromolecular Materials and Engineering}, author={Ruediger, Arne A.
and Bremser, Wolfgang and Strube, Oliver I.}, year={2016}, pages={1181–1190} }'
chicago: Ruediger, Arne A., Wolfgang Bremser, and Oliver I. Strube. “Nanoscaled
Biocoatings via Enzyme Mediated Autodeposition of Casein.” Macromolecular Materials
and Engineering, 2016, 1181–90. https://doi.org/10.1002/mame.201600034.
ieee: 'A. A. Ruediger, W. Bremser, and O. I. Strube, “Nanoscaled Biocoatings via
Enzyme Mediated Autodeposition of Casein,” Macromolecular Materials and Engineering,
pp. 1181–1190, 2016, doi: 10.1002/mame.201600034.'
mla: Ruediger, Arne A., et al. “Nanoscaled Biocoatings via Enzyme Mediated Autodeposition
of Casein.” Macromolecular Materials and Engineering, 2016, pp. 1181–90,
doi:10.1002/mame.201600034.
short: A.A. Ruediger, W. Bremser, O.I. Strube, Macromolecular Materials and Engineering
(2016) 1181–1190.
date_created: 2021-10-04T13:37:17Z
date_updated: 2022-01-06T06:57:00Z
department:
- _id: '321'
- _id: '301'
doi: 10.1002/mame.201600034
language:
- iso: eng
page: 1181-1190
publication: Macromolecular Materials and Engineering
publication_identifier:
issn:
- 1438-7492
publication_status: published
status: public
title: Nanoscaled Biocoatings via Enzyme Mediated Autodeposition of Casein
type: journal_article
user_id: '32'
year: '2016'
...
---
_id: '25311'
author:
- first_name: Oliver I.
full_name: Strube, Oliver I.
last_name: Strube
- first_name: Anne
full_name: Büngeler, Anne
last_name: Büngeler
- first_name: Wolfgang
full_name: Bremser, Wolfgang
last_name: Bremser
citation:
ama: Strube OI, Büngeler A, Bremser W. Enzyme-Mediated In Situ Synthesis and Deposition
of Nonaggregated Melanin Protoparticles. Macromolecular Materials and Engineering.
Published online 2016:801-804. doi:10.1002/mame.201500315
apa: Strube, O. I., Büngeler, A., & Bremser, W. (2016). Enzyme-Mediated In Situ
Synthesis and Deposition of Nonaggregated Melanin Protoparticles. Macromolecular
Materials and Engineering, 801–804. https://doi.org/10.1002/mame.201500315
bibtex: '@article{Strube_Büngeler_Bremser_2016, title={Enzyme-Mediated In Situ Synthesis
and Deposition of Nonaggregated Melanin Protoparticles}, DOI={10.1002/mame.201500315},
journal={Macromolecular Materials and Engineering}, author={Strube, Oliver I.
and Büngeler, Anne and Bremser, Wolfgang}, year={2016}, pages={801–804} }'
chicago: Strube, Oliver I., Anne Büngeler, and Wolfgang Bremser. “Enzyme-Mediated
In Situ Synthesis and Deposition of Nonaggregated Melanin Protoparticles.” Macromolecular
Materials and Engineering, 2016, 801–4. https://doi.org/10.1002/mame.201500315.
ieee: 'O. I. Strube, A. Büngeler, and W. Bremser, “Enzyme-Mediated In Situ Synthesis
and Deposition of Nonaggregated Melanin Protoparticles,” Macromolecular Materials
and Engineering, pp. 801–804, 2016, doi: 10.1002/mame.201500315.'
mla: Strube, Oliver I., et al. “Enzyme-Mediated In Situ Synthesis and Deposition
of Nonaggregated Melanin Protoparticles.” Macromolecular Materials and Engineering,
2016, pp. 801–04, doi:10.1002/mame.201500315.
short: O.I. Strube, A. Büngeler, W. Bremser, Macromolecular Materials and Engineering
(2016) 801–804.
date_created: 2021-10-04T13:38:41Z
date_updated: 2022-01-06T06:57:00Z
department:
- _id: '321'
- _id: '301'
doi: 10.1002/mame.201500315
language:
- iso: eng
page: 801-804
publication: Macromolecular Materials and Engineering
publication_identifier:
issn:
- 1438-7492
publication_status: published
status: public
title: Enzyme-Mediated In Situ Synthesis and Deposition of Nonaggregated Melanin Protoparticles
type: journal_article
user_id: '32'
year: '2016'
...