---
_id: '51121'
abstract:
- lang: eng
  text: <jats:p>DNA origami nanostructures are a powerful tool in biomedicine and
    can be used to combat drug‐resistant bacterial infections. However, the effect
    of unmodified DNA origami nanostructures on bacteria is yet to be elucidated.
    With the aim to obtain a better understanding of this phenomenon, the effect of
    three DNA origami shapes, i.e., DNA origami triangles, six‐helix bundles (6HBs),
    and 24‐helix bundles (24HBs), on the growth of Gram‐negative Escherichia coli
    and Gram‐positive Bacillus subtilis is investigated. These results reveal that
    while triangles and 24HBs can be used as a source of nutrients by E. coli and
    thereby promote population growth, their effect is much smaller than that of genomic
    single‐ and double‐stranded DNA. However, no effect on E. coli population growth
    is observed for the 6HBs. On the other hand, B. subtilis does not show any significant
    changes in population growth when cultured with the different DNA origami shapes
    or genomic DNA. The detailed effect of DNA origami nanostructures on bacterial
    growth thus depends on the competence signals and uptake mechanism of each bacterial
    species, as well as the DNA origami shape. This should be considered in the development
    of antimicrobial DNA origami nanostructures.</jats:p>
author:
- first_name: Jaime Andres
  full_name: Garcia-Diosa, Jaime Andres
  last_name: Garcia-Diosa
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Adrian
  full_name: Keller, Adrian
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
citation:
  ama: Garcia-Diosa JA, Grundmeier G, Keller A. Effect of DNA Origami Nanostructures
    on Bacterial Growth. <i>ChemBioChem</i>. Published online 2024. doi:<a href="https://doi.org/10.1002/cbic.202400091">10.1002/cbic.202400091</a>
  apa: Garcia-Diosa, J. A., Grundmeier, G., &#38; Keller, A. (2024). Effect of DNA
    Origami Nanostructures on Bacterial Growth. <i>ChemBioChem</i>. <a href="https://doi.org/10.1002/cbic.202400091">https://doi.org/10.1002/cbic.202400091</a>
  bibtex: '@article{Garcia-Diosa_Grundmeier_Keller_2024, title={Effect of DNA Origami
    Nanostructures on Bacterial Growth}, DOI={<a href="https://doi.org/10.1002/cbic.202400091">10.1002/cbic.202400091</a>},
    journal={ChemBioChem}, publisher={Wiley}, author={Garcia-Diosa, Jaime Andres and
    Grundmeier, Guido and Keller, Adrian}, year={2024} }'
  chicago: Garcia-Diosa, Jaime Andres, Guido Grundmeier, and Adrian Keller. “Effect
    of DNA Origami Nanostructures on Bacterial Growth.” <i>ChemBioChem</i>, 2024.
    <a href="https://doi.org/10.1002/cbic.202400091">https://doi.org/10.1002/cbic.202400091</a>.
  ieee: 'J. A. Garcia-Diosa, G. Grundmeier, and A. Keller, “Effect of DNA Origami
    Nanostructures on Bacterial Growth,” <i>ChemBioChem</i>, 2024, doi: <a href="https://doi.org/10.1002/cbic.202400091">10.1002/cbic.202400091</a>.'
  mla: Garcia-Diosa, Jaime Andres, et al. “Effect of DNA Origami Nanostructures on
    Bacterial Growth.” <i>ChemBioChem</i>, Wiley, 2024, doi:<a href="https://doi.org/10.1002/cbic.202400091">10.1002/cbic.202400091</a>.
  short: J.A. Garcia-Diosa, G. Grundmeier, A. Keller, ChemBioChem (2024).
date_created: 2024-02-03T12:41:16Z
date_updated: 2024-02-03T12:42:48Z
department:
- _id: '302'
doi: 10.1002/cbic.202400091
keyword:
- Organic Chemistry
- Molecular Biology
- Molecular Medicine
- Biochemistry
language:
- iso: eng
publication: ChemBioChem
publication_identifier:
  issn:
  - 1439-4227
  - 1439-7633
publication_status: published
publisher: Wiley
status: public
title: Effect of DNA Origami Nanostructures on Bacterial Growth
type: journal_article
user_id: '48864'
year: '2024'
...
---
_id: '44503'
author:
- first_name: Marcel
  full_name: Hanke, Marcel
  last_name: Hanke
- first_name: Emilia
  full_name: Tomm, Emilia
  last_name: Tomm
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Adrian
  full_name: Keller, Adrian
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
citation:
  ama: Hanke M, Tomm E, Grundmeier G, Keller A. Effect of Ionic Strength on the Thermal
    Stability of DNA Origami Nanostructures. <i>ChemBioChem</i>. Published online
    2023. doi:<a href="https://doi.org/10.1002/cbic.202300338">10.1002/cbic.202300338</a>
  apa: Hanke, M., Tomm, E., Grundmeier, G., &#38; Keller, A. (2023). Effect of Ionic
    Strength on the Thermal Stability of DNA Origami Nanostructures. <i>ChemBioChem</i>.
    <a href="https://doi.org/10.1002/cbic.202300338">https://doi.org/10.1002/cbic.202300338</a>
  bibtex: '@article{Hanke_Tomm_Grundmeier_Keller_2023, title={Effect of Ionic Strength
    on the Thermal Stability of DNA Origami Nanostructures}, DOI={<a href="https://doi.org/10.1002/cbic.202300338">10.1002/cbic.202300338</a>},
    journal={ChemBioChem}, publisher={Wiley}, author={Hanke, Marcel and Tomm, Emilia
    and Grundmeier, Guido and Keller, Adrian}, year={2023} }'
  chicago: Hanke, Marcel, Emilia Tomm, Guido Grundmeier, and Adrian Keller. “Effect
    of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures.” <i>ChemBioChem</i>,
    2023. <a href="https://doi.org/10.1002/cbic.202300338">https://doi.org/10.1002/cbic.202300338</a>.
  ieee: 'M. Hanke, E. Tomm, G. Grundmeier, and A. Keller, “Effect of Ionic Strength
    on the Thermal Stability of DNA Origami Nanostructures,” <i>ChemBioChem</i>, 2023,
    doi: <a href="https://doi.org/10.1002/cbic.202300338">10.1002/cbic.202300338</a>.'
  mla: Hanke, Marcel, et al. “Effect of Ionic Strength on the Thermal Stability of
    DNA Origami Nanostructures.” <i>ChemBioChem</i>, Wiley, 2023, doi:<a href="https://doi.org/10.1002/cbic.202300338">10.1002/cbic.202300338</a>.
  short: M. Hanke, E. Tomm, G. Grundmeier, A. Keller, ChemBioChem (2023).
date_created: 2023-05-05T10:47:29Z
date_updated: 2023-05-05T10:48:00Z
department:
- _id: '302'
doi: 10.1002/cbic.202300338
keyword:
- Organic Chemistry
- Molecular Biology
- Molecular Medicine
- Biochemistry
language:
- iso: eng
publication: ChemBioChem
publication_identifier:
  issn:
  - 1439-4227
  - 1439-7633
publication_status: published
publisher: Wiley
status: public
title: Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures
type: journal_article
user_id: '48864'
year: '2023'
...
---
_id: '22655'
author:
- first_name: S
  full_name: Ramakrishnan, S
  last_name: Ramakrishnan
- first_name: B
  full_name: Shen, B
  last_name: Shen
- first_name: MA
  full_name: Kostiainen, MA
  last_name: Kostiainen
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Adrian
  full_name: Keller, Adrian
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
- first_name: V
  full_name: Linko, V
  last_name: Linko
citation:
  ama: Ramakrishnan S, Shen B, Kostiainen M, Grundmeier G, Keller A, Linko V. Real-Time
    Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using
    High-Speed Atomic Force Microscopy. <i>ChemBioChem</i>. 2019;20(22):2818-2823.
    doi:<a href="https://doi.org/10.1002/cbic.201900369">10.1002/cbic.201900369</a>
  apa: Ramakrishnan, S., Shen, B., Kostiainen, M., Grundmeier, G., Keller, A., &#38;
    Linko, V. (2019). Real-Time Observation of Superstructure-Dependent DNA Origami
    Digestion by DNase I Using High-Speed Atomic Force Microscopy. <i>ChemBioChem</i>,
    <i>20</i>(22), 2818–2823. <a href="https://doi.org/10.1002/cbic.201900369">https://doi.org/10.1002/cbic.201900369</a>
  bibtex: '@article{Ramakrishnan_Shen_Kostiainen_Grundmeier_Keller_Linko_2019, title={Real-Time
    Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using
    High-Speed Atomic Force Microscopy.}, volume={20}, DOI={<a href="https://doi.org/10.1002/cbic.201900369">10.1002/cbic.201900369</a>},
    number={22}, journal={ChemBioChem}, author={Ramakrishnan, S and Shen, B and Kostiainen,
    MA and Grundmeier, Guido and Keller, Adrian and Linko, V}, year={2019}, pages={2818–2823}
    }'
  chicago: 'Ramakrishnan, S, B Shen, MA Kostiainen, Guido Grundmeier, Adrian Keller,
    and V Linko. “Real-Time Observation of Superstructure-Dependent DNA Origami Digestion
    by DNase I Using High-Speed Atomic Force Microscopy.” <i>ChemBioChem</i> 20, no.
    22 (2019): 2818–23. <a href="https://doi.org/10.1002/cbic.201900369">https://doi.org/10.1002/cbic.201900369</a>.'
  ieee: S. Ramakrishnan, B. Shen, M. Kostiainen, G. Grundmeier, A. Keller, and V.
    Linko, “Real-Time Observation of Superstructure-Dependent DNA Origami Digestion
    by DNase I Using High-Speed Atomic Force Microscopy.,” <i>ChemBioChem</i>, vol.
    20, no. 22, pp. 2818–2823, 2019.
  mla: Ramakrishnan, S., et al. “Real-Time Observation of Superstructure-Dependent
    DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy.” <i>ChemBioChem</i>,
    vol. 20, no. 22, 2019, pp. 2818–23, doi:<a href="https://doi.org/10.1002/cbic.201900369">10.1002/cbic.201900369</a>.
  short: S. Ramakrishnan, B. Shen, M. Kostiainen, G. Grundmeier, A. Keller, V. Linko,
    ChemBioChem 20 (2019) 2818–2823.
date_created: 2021-07-08T12:14:23Z
date_updated: 2022-01-06T06:55:38Z
department:
- _id: '302'
doi: 10.1002/cbic.201900369
external_id:
  pmid:
  - '31163091'
intvolume: '        20'
issue: '22'
language:
- iso: eng
page: 2818-2823
pmid: '1'
publication: ChemBioChem
publication_identifier:
  issn:
  - 1439-4227
  - 1439-7633
status: public
title: Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by
  DNase I Using High-Speed Atomic Force Microscopy.
type: journal_article
user_id: '48864'
volume: 20
year: '2019'
...