[{"title":"Effect of DNA Origami Nanostructures on Bacterial Growth","doi":"10.1002/cbic.202400091","date_updated":"2024-02-03T12:42:48Z","publisher":"Wiley","date_created":"2024-02-03T12:41:16Z","author":[{"last_name":"Garcia-Diosa","full_name":"Garcia-Diosa, Jaime Andres","first_name":"Jaime Andres"},{"first_name":"Guido","id":"194","full_name":"Grundmeier, Guido","last_name":"Grundmeier"},{"orcid":"0000-0001-7139-3110","last_name":"Keller","id":"48864","full_name":"Keller, Adrian","first_name":"Adrian"}],"year":"2024","citation":{"mla":"Garcia-Diosa, Jaime Andres, et al. “Effect of DNA Origami Nanostructures on Bacterial Growth.” <i>ChemBioChem</i>, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>.","short":"J.A. Garcia-Diosa, G. Grundmeier, A. Keller, ChemBioChem (2024).","bibtex":"@article{Garcia-Diosa_Grundmeier_Keller_2024, title={Effect of DNA Origami Nanostructures on Bacterial Growth}, DOI={<a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>}, journal={ChemBioChem}, publisher={Wiley}, author={Garcia-Diosa, Jaime Andres and Grundmeier, Guido and Keller, Adrian}, year={2024} }","apa":"Garcia-Diosa, J. A., Grundmeier, G., &#38; Keller, A. (2024). Effect of DNA Origami Nanostructures on Bacterial Growth. <i>ChemBioChem</i>. <a href=\"https://doi.org/10.1002/cbic.202400091\">https://doi.org/10.1002/cbic.202400091</a>","ama":"Garcia-Diosa JA, Grundmeier G, Keller A. Effect of DNA Origami Nanostructures on Bacterial Growth. <i>ChemBioChem</i>. Published online 2024. doi:<a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>","chicago":"Garcia-Diosa, Jaime Andres, Guido Grundmeier, and Adrian Keller. “Effect of DNA Origami Nanostructures on Bacterial Growth.” <i>ChemBioChem</i>, 2024. <a href=\"https://doi.org/10.1002/cbic.202400091\">https://doi.org/10.1002/cbic.202400091</a>.","ieee":"J. A. Garcia-Diosa, G. Grundmeier, and A. Keller, “Effect of DNA Origami Nanostructures on Bacterial Growth,” <i>ChemBioChem</i>, 2024, doi: <a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>."},"publication_status":"published","publication_identifier":{"issn":["1439-4227","1439-7633"]},"keyword":["Organic Chemistry","Molecular Biology","Molecular Medicine","Biochemistry"],"language":[{"iso":"eng"}],"_id":"51121","user_id":"48864","department":[{"_id":"302"}],"abstract":[{"text":"<jats:p>DNA origami nanostructures are a powerful tool in biomedicine and can be used to combat drug‐resistant bacterial infections. However, the effect of unmodified DNA origami nanostructures on bacteria is yet to be elucidated. With the aim to obtain a better understanding of this phenomenon, the effect of three DNA origami shapes, i.e., DNA origami triangles, six‐helix bundles (6HBs), and 24‐helix bundles (24HBs), on the growth of Gram‐negative Escherichia coli and Gram‐positive Bacillus subtilis is investigated. These results reveal that while triangles and 24HBs can be used as a source of nutrients by E. coli and thereby promote population growth, their effect is much smaller than that of genomic single‐ and double‐stranded DNA. However, no effect on E. coli population growth is observed for the 6HBs. On the other hand, B. subtilis does not show any significant changes in population growth when cultured with the different DNA origami shapes or genomic DNA. The detailed effect of DNA origami nanostructures on bacterial growth thus depends on the competence signals and uptake mechanism of each bacterial species, as well as the DNA origami shape. This should be considered in the development of antimicrobial DNA origami nanostructures.</jats:p>","lang":"eng"}],"status":"public","type":"journal_article","publication":"ChemBioChem"},{"doi":"10.1002/cbic.202300338","title":"Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures","date_created":"2023-05-05T10:47:29Z","author":[{"first_name":"Marcel","full_name":"Hanke, Marcel","last_name":"Hanke"},{"first_name":"Emilia","last_name":"Tomm","full_name":"Tomm, Emilia"},{"full_name":"Grundmeier, Guido","id":"194","last_name":"Grundmeier","first_name":"Guido"},{"first_name":"Adrian","full_name":"Keller, Adrian","id":"48864","last_name":"Keller","orcid":"0000-0001-7139-3110"}],"publisher":"Wiley","date_updated":"2023-05-05T10:48:00Z","citation":{"ama":"Hanke M, Tomm E, Grundmeier G, Keller A. Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures. <i>ChemBioChem</i>. Published online 2023. doi:<a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>","chicago":"Hanke, Marcel, Emilia Tomm, Guido Grundmeier, and Adrian Keller. “Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures.” <i>ChemBioChem</i>, 2023. <a href=\"https://doi.org/10.1002/cbic.202300338\">https://doi.org/10.1002/cbic.202300338</a>.","ieee":"M. Hanke, E. Tomm, G. Grundmeier, and A. Keller, “Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures,” <i>ChemBioChem</i>, 2023, doi: <a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>.","bibtex":"@article{Hanke_Tomm_Grundmeier_Keller_2023, title={Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures}, DOI={<a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>}, journal={ChemBioChem}, publisher={Wiley}, author={Hanke, Marcel and Tomm, Emilia and Grundmeier, Guido and Keller, Adrian}, year={2023} }","mla":"Hanke, Marcel, et al. “Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures.” <i>ChemBioChem</i>, Wiley, 2023, doi:<a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>.","short":"M. Hanke, E. Tomm, G. Grundmeier, A. Keller, ChemBioChem (2023).","apa":"Hanke, M., Tomm, E., Grundmeier, G., &#38; Keller, A. (2023). Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures. <i>ChemBioChem</i>. <a href=\"https://doi.org/10.1002/cbic.202300338\">https://doi.org/10.1002/cbic.202300338</a>"},"year":"2023","publication_identifier":{"issn":["1439-4227","1439-7633"]},"publication_status":"published","language":[{"iso":"eng"}],"keyword":["Organic Chemistry","Molecular Biology","Molecular Medicine","Biochemistry"],"department":[{"_id":"302"}],"user_id":"48864","_id":"44503","status":"public","publication":"ChemBioChem","type":"journal_article"},{"citation":{"chicago":"Ramakrishnan, S, B Shen, MA Kostiainen, Guido Grundmeier, Adrian Keller, and V Linko. “Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy.” <i>ChemBioChem</i> 20, no. 22 (2019): 2818–23. <a href=\"https://doi.org/10.1002/cbic.201900369\">https://doi.org/10.1002/cbic.201900369</a>.","ieee":"S. Ramakrishnan, B. Shen, M. Kostiainen, G. Grundmeier, A. Keller, and V. Linko, “Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy.,” <i>ChemBioChem</i>, vol. 20, no. 22, pp. 2818–2823, 2019.","ama":"Ramakrishnan S, Shen B, Kostiainen M, Grundmeier G, Keller A, Linko V. Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy. <i>ChemBioChem</i>. 2019;20(22):2818-2823. doi:<a href=\"https://doi.org/10.1002/cbic.201900369\">10.1002/cbic.201900369</a>","apa":"Ramakrishnan, S., Shen, B., Kostiainen, M., Grundmeier, G., Keller, A., &#38; Linko, V. (2019). Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy. <i>ChemBioChem</i>, <i>20</i>(22), 2818–2823. <a href=\"https://doi.org/10.1002/cbic.201900369\">https://doi.org/10.1002/cbic.201900369</a>","short":"S. Ramakrishnan, B. Shen, M. Kostiainen, G. Grundmeier, A. Keller, V. Linko, ChemBioChem 20 (2019) 2818–2823.","bibtex":"@article{Ramakrishnan_Shen_Kostiainen_Grundmeier_Keller_Linko_2019, title={Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy.}, volume={20}, DOI={<a href=\"https://doi.org/10.1002/cbic.201900369\">10.1002/cbic.201900369</a>}, number={22}, journal={ChemBioChem}, author={Ramakrishnan, S and Shen, B and Kostiainen, MA and Grundmeier, Guido and Keller, Adrian and Linko, V}, year={2019}, pages={2818–2823} }","mla":"Ramakrishnan, S., et al. “Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy.” <i>ChemBioChem</i>, vol. 20, no. 22, 2019, pp. 2818–23, doi:<a href=\"https://doi.org/10.1002/cbic.201900369\">10.1002/cbic.201900369</a>."},"intvolume":"        20","page":"2818-2823","publication_identifier":{"issn":["1439-4227","1439-7633"]},"pmid":"1","doi":"10.1002/cbic.201900369","date_updated":"2022-01-06T06:55:38Z","author":[{"last_name":"Ramakrishnan","full_name":"Ramakrishnan, S","first_name":"S"},{"first_name":"B","last_name":"Shen","full_name":"Shen, B"},{"first_name":"MA","full_name":"Kostiainen, MA","last_name":"Kostiainen"},{"first_name":"Guido","id":"194","full_name":"Grundmeier, Guido","last_name":"Grundmeier"},{"full_name":"Keller, Adrian","id":"48864","last_name":"Keller","orcid":"0000-0001-7139-3110","first_name":"Adrian"},{"full_name":"Linko, V","last_name":"Linko","first_name":"V"}],"volume":20,"status":"public","type":"journal_article","_id":"22655","user_id":"48864","department":[{"_id":"302"}],"year":"2019","issue":"22","title":"Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy.","date_created":"2021-07-08T12:14:23Z","publication":"ChemBioChem","language":[{"iso":"eng"}],"external_id":{"pmid":["31163091"]}}]