---
_id: '60046'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and purpose</jats:title><jats:p>Valid
    measurements of cardiorespiratory fitness in persons with multiple sclerosis (pwMS)
    are essential during inpatient rehabilitation for a precise evaluation of the
    current health status, for defining appropriate exercise intensities, and for
    evaluation of exercise intervention studies. We aim (i) to examine the proportion
    of pwMS who attain the American College of Sports Medicine (ACSM) criteria for
    maximal effort during graded cardiopulmonary exercise testing (CPET) and (ii)
    to provide insight into participant characteristics that limit maximal exercise
    performance.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This
    cross‐sectional study comprises a retrospective examination of ACSM criteria for
    maximal effort during graded CPET of <jats:italic>n</jats:italic> = 380 inpatient
    pwMS (mean age = 48 ± 11 years, 66% female). Chi‐squared or Fisher's exact tests
    were conducted to compare differences in the distribution of criteria achieved.
    Participants' characteristics were examined as potential predictors using binary
    logistic regression.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Only
    60% of the overall sample attained a respiratory exchange ratio ≥ 1.10. With regard
    to the definition applied, only 24% or 40% of the participants achieved an oxygen
    consumption plateau, and 17% or 50% attained the heart rate criterion. Forty‐six
    percent met at least two of three criteria. Disability status, gender, disease
    course, and body mass index were associated with the attainment of maximal effort.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our
    findings suggest that a relevant proportion of inpatient pwMS do not attain common
    criteria utilized to verify maximal oxygen consumption. Identified predictors
    for criteria attainment can be used to create models to predict cardiorespiratory
    fitness and to optimize CPET protocols in restrictive groups of pwMS.</jats:p></jats:sec>
author:
- first_name: Marit Lea
  full_name: Schlagheck, Marit Lea
  id: '117661'
  last_name: Schlagheck
  orcid: '0000-0002-8913-6080 '
- first_name: Jens
  full_name: Bansi, Jens
  last_name: Bansi
- first_name: Charlotte
  full_name: Wenzel, Charlotte
  last_name: Wenzel
- first_name: Marina
  full_name: Kuzdas‐Sallaberger, Marina
  last_name: Kuzdas‐Sallaberger
- first_name: David
  full_name: Kiesl, David
  last_name: Kiesl
- first_name: Roman
  full_name: Gonzenbach, Roman
  last_name: Gonzenbach
- first_name: Philipp
  full_name: Zimmer, Philipp
  last_name: Zimmer
citation:
  ama: Schlagheck ML, Bansi J, Wenzel C, et al. Complexity and pitfalls in maximal
    exercise testing for persons with multiple sclerosis. <i>European Journal of Neurology</i>.
    2023;30(9):2726-2735. doi:<a href="https://doi.org/10.1111/ene.15875">10.1111/ene.15875</a>
  apa: Schlagheck, M. L., Bansi, J., Wenzel, C., Kuzdas‐Sallaberger, M., Kiesl, D.,
    Gonzenbach, R., &#38; Zimmer, P. (2023). Complexity and pitfalls in maximal exercise
    testing for persons with multiple sclerosis. <i>European Journal of Neurology</i>,
    <i>30</i>(9), 2726–2735. <a href="https://doi.org/10.1111/ene.15875">https://doi.org/10.1111/ene.15875</a>
  bibtex: '@article{Schlagheck_Bansi_Wenzel_Kuzdas‐Sallaberger_Kiesl_Gonzenbach_Zimmer_2023,
    title={Complexity and pitfalls in maximal exercise testing for persons with multiple
    sclerosis}, volume={30}, DOI={<a href="https://doi.org/10.1111/ene.15875">10.1111/ene.15875</a>},
    number={9}, journal={European Journal of Neurology}, publisher={Wiley}, author={Schlagheck,
    Marit Lea and Bansi, Jens and Wenzel, Charlotte and Kuzdas‐Sallaberger, Marina
    and Kiesl, David and Gonzenbach, Roman and Zimmer, Philipp}, year={2023}, pages={2726–2735}
    }'
  chicago: 'Schlagheck, Marit Lea, Jens Bansi, Charlotte Wenzel, Marina Kuzdas‐Sallaberger,
    David Kiesl, Roman Gonzenbach, and Philipp Zimmer. “Complexity and Pitfalls in
    Maximal Exercise Testing for Persons with Multiple Sclerosis.” <i>European Journal
    of Neurology</i> 30, no. 9 (2023): 2726–35. <a href="https://doi.org/10.1111/ene.15875">https://doi.org/10.1111/ene.15875</a>.'
  ieee: 'M. L. Schlagheck <i>et al.</i>, “Complexity and pitfalls in maximal exercise
    testing for persons with multiple sclerosis,” <i>European Journal of Neurology</i>,
    vol. 30, no. 9, pp. 2726–2735, 2023, doi: <a href="https://doi.org/10.1111/ene.15875">10.1111/ene.15875</a>.'
  mla: Schlagheck, Marit Lea, et al. “Complexity and Pitfalls in Maximal Exercise
    Testing for Persons with Multiple Sclerosis.” <i>European Journal of Neurology</i>,
    vol. 30, no. 9, Wiley, 2023, pp. 2726–35, doi:<a href="https://doi.org/10.1111/ene.15875">10.1111/ene.15875</a>.
  short: M.L. Schlagheck, J. Bansi, C. Wenzel, M. Kuzdas‐Sallaberger, D. Kiesl, R.
    Gonzenbach, P. Zimmer, European Journal of Neurology 30 (2023) 2726–2735.
date_created: 2025-05-27T07:54:42Z
date_updated: 2025-06-02T09:34:01Z
doi: 10.1111/ene.15875
extern: '1'
intvolume: '        30'
issue: '9'
language:
- iso: eng
page: 2726-2735
publication: European Journal of Neurology
publication_identifier:
  issn:
  - 1351-5101
  - 1468-1331
publication_status: published
publisher: Wiley
status: public
title: Complexity and pitfalls in maximal exercise testing for persons with multiple
  sclerosis
type: journal_article
user_id: '117661'
volume: 30
year: '2023'
...