@article{60719,
abstract = {{Abstract
Background
Parkinson’s Disease (PD) bears a variety of sex differences and is associated with cardiovascular dysregulation (CDR). Variation in the routinely assessed standard parameters heart rate (HR) and blood pressure (BP) seem not well understood within the frame of sex-specific developments under therapy. Parameters of heart rate variability (RMSSD) and electrodermal activity (meanEDA) may assist the understanding of underlying autonomic developments. This pilot study aims to describe sex-specific cardiovascular and autonomic responses to a multimodal inpatient rehabilitation program in patients with PD.
Methods
Forty-one PD patients (24 male, 17 female) participated in a stationary, multimodal therapy intervention (MTI). Before and after MTI, HR, BP, RMSSD, and meanEDA were assessed in supine baseline (5 min of rest before orthostasis) and during supine adaption to rest (5 min of rest after orthostasis). Differences between baseline and adaption to rest as well as differences over time of MTI were calculated using Wilcoxon test; sex differences using Mann–Whitney-U test.
Results
Before MTI, women’s supine HR (p = .034*; d = .17) and BP (p = .015*, d = 0.4) were significantly higher during adaption to rest than during baseline. After MTI, women’s supine HR (p = .020*; d = .84) and BP (p = .022*, d = 0.5) during adaption to rest had decreased significantly. Men’s HR and BP remained constant and without differences between the supine conditions. RMSSD and meanEDA remained steady in both sexes.
Conclusion
The sex-specific responsiveness to MTI supports the concept of sex-sensitive therapeutic management for cardiovascular symptoms in PD. In both sexes, peripheral cardiovascular outcomes appeared not attributable to corresponding outcomes in autonomic regulation. Further examination of autonomic parameters could provide a foundation for developing therapeutic approaches that address central nervous system mechanisms.
The study was officially registered (08/2020). The data supporting the findings of this study are available under http://apps.who.int/trialsearch/ under trial number DRKS00022773.
}},
author = {{Siche-Pantel, Franziska and Mühlenberg, Manfred and Buschfort, Rüdiger and Michels, Heinke and Jakobsmeyer, Rasmus and Oesterschlink, Julian and Reinsberger, Claus}},
issn = {{1471-2377}},
journal = {{BMC Neurology}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study}}},
doi = {{10.1186/s12883-025-04281-7}},
volume = {{25}},
year = {{2025}},
}
@article{30119,
abstract = {{Abstract
Background
Subjective Memory Complaints (SMC) in elderly people due to preclinical Alzheimer’s Disease may be associated with dysregulation of the Kynurenine Pathway (KP), with an increase in neurotoxic metabolites that affect cognition. Golf is a challenging sport with high demands on motor, sensory, and cognitive abilities, which might bear the potential to attenuate the pathological changes of preclinical AD. This trial investigated the feasibility of learning to play golf for elderly with cognitive problems and its effects on cognitive functions and the KP.
Methods
In a 22-week single-blinded randomized controlled trial, elderly people with SMC were allocated to the golf (n = 25, 180 min training/week) or control group (n = 21). Primary outcomes were feasibility (golf exam, adherence, adverse events) and general cognitive function (Alzheimer’s Disease Assessment Scale). Secondary outcomes include specific cognitive functions (Response Inhibition, Corsi Block Tapping Test, Trail Making Test), KP metabolites and physical performance (6-Minute-Walk-Test). Baseline-adjusted Analysis-of-Covariance was conducted for each outcome.
Results
42 participants were analyzed. All participants that underwent the golf exam after the intervention passed it (20/23). Attendance rate of the golf intervention was 75 %. No adverse events or drop-outs related to the intervention occurred. A significant time*group interaction (p = 0.012, F = 7.050, Cohen’s d = 0.89) was found for correct responses on the Response Inhibition task, but not for ADAS-Cog. Moreover, a significant time*group interaction for Quinolinic acid to Tryptophan ratios (p = 0.022, F = 5.769, Cohen’s d = 0.84) in favor of the golf group was observed. An uncorrected negative correlation between attendance rate and delta Quinolinic acid to Kynurenic acid ratios in the golf group (p = 0.039, r=-0.443) was found as well.
Conclusions
The findings indicate that learning golf is feasible and safe for elderly people with cognitive problems. Preliminary results suggest positive effects on attention and the KP. To explore the whole potential of golfing and its effect on cognitive decline, a larger cohort should be studied over a longer period with higher cardiovascular demands.
Trial registration
The trial was retrospectively registered (2nd July 2018) at the German Clinical Trials Register (DRKS00014921).
}},
author = {{Stroehlein, Julia K. and Vieluf, Solveig and Zimmer, Philipp and Schenk, Alexander and Oberste, Max and Gölz, Christian Johannes and van den Bongard, Franziska and Reinsberger, Claus}},
issn = {{1471-2377}},
journal = {{BMC Neurology}},
keywords = {{Clinical Neurology, General Medicine}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Learning to play golf for elderly people with subjective memory complaints: feasibility of a single‐blinded randomized pilot trial}}},
doi = {{10.1186/s12883-021-02186-9}},
volume = {{21}},
year = {{2021}},
}
@article{60088,
author = {{Proschinger, Sebastian and Joisten, Niklas and Rademacher, Annette and Schlagheck, Marit Lea and Walzik, David and Metcalfe, Alan J. and Oberste, Max and Warnke, Clemens and Bloch, Wilhelm and Schenk, Alexander and Bansi, Jens and Zimmer, Philipp}},
issn = {{1471-2377}},
journal = {{BMC Neurology}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial}}},
doi = {{10.1186/s12883-019-1544-7}},
volume = {{19}},
year = {{2019}},
}