---
_id: '27800'
abstract:
- lang: eng
text: A lower 24-h urine pH (24h-pH), i.e., a higher renal excretion of
free protons, at a given acid load to the body, denotes a reduction in the kidney’s
capacity for net acid excretion (NAE). There is increasing evidence, not only
for patients with type 2 diabetes but also for healthy individuals, that higher
body fatness or waist circumference (WC) has a negative impact on renal function
to excrete acids (NAE). We hypothesized that adiposity-related inflammation molecules
might mediate this relation between adiposity and renal acid excretion function.
Twelve biomarkers of inflammation were measured in fasting blood samples from
162 adult participants (18–25 yr old) of the Dortmund Nutritional and Anthropometric
Longitudinally Designed (DONALD) study who had undergone anthropometric measurements
and collected 24-h urine samples. Both Baron and Kenny’s (B&K’s) steps to
test mediation and causal mediation analysis were conducted to examine the potential
mediatory roles of biomarkers of inflammation in the WC-24-h pH relationship after
strictly controlling for laboratory-measured NAE. In B&K’s mediation analysis,
leptin, soluble intercellular adhesion molecule 1 (sICAM-1), and adiponectin significantly
associated with the outcome 24-h pH and attenuated the WC-pH relation. In agreement
herewith, causal mediation analysis estimated the “natural indirect effects” of
WC on 24-h pH via leptin ( P = 0.01) and adiponectin ( P = 0.03) to be significant,
with a trend for sICAM-1 ( P = 0.09). The calculated proportions mediated by leptin,
adiponectin, and sICAM-1 were 64%, 23%, and 12%, respectively. Both mediation
analyses identified an inflammatory cytokine (leptin) and an anti-inflammatory
cytokine (adiponectin) along with sICAM-1 as being potentially involved in mediating
adiposity-related influences on renal acid excretion capacity.
author:
- first_name: Yifan
full_name: Hua, Yifan
last_name: Hua
- first_name: Christian
full_name: Herder, Christian
last_name: Herder
- first_name: Hermann
full_name: Kalhoff, Hermann
last_name: Kalhoff
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
- first_name: Jonas
full_name: Esche, Jonas
last_name: Esche
- first_name: Danika
full_name: Krupp, Danika
last_name: Krupp
- first_name: Stefan A.
full_name: Wudy, Stefan A.
last_name: Wudy
- first_name: Thomas
full_name: Remer, Thomas
last_name: Remer
citation:
ama: 'Hua Y, Herder C, Kalhoff H, et al. Inflammatory mediators in the adipo-renal
axis: leptin, adiponectin, and soluble ICAM-1. American Journal of Physiology-Renal
Physiology. Published online 2020:F469-F475. doi:10.1152/ajprenal.00257.2020'
apa: 'Hua, Y., Herder, C., Kalhoff, H., Buyken, A., Esche, J., Krupp, D., Wudy,
S. A., & Remer, T. (2020). Inflammatory mediators in the adipo-renal axis:
leptin, adiponectin, and soluble ICAM-1. American Journal of Physiology-Renal
Physiology, F469–F475. https://doi.org/10.1152/ajprenal.00257.2020'
bibtex: '@article{Hua_Herder_Kalhoff_Buyken_Esche_Krupp_Wudy_Remer_2020, title={Inflammatory
mediators in the adipo-renal axis: leptin, adiponectin, and soluble ICAM-1}, DOI={10.1152/ajprenal.00257.2020},
journal={American Journal of Physiology-Renal Physiology}, author={Hua, Yifan
and Herder, Christian and Kalhoff, Hermann and Buyken, Anette and Esche, Jonas
and Krupp, Danika and Wudy, Stefan A. and Remer, Thomas}, year={2020}, pages={F469–F475}
}'
chicago: 'Hua, Yifan, Christian Herder, Hermann Kalhoff, Anette Buyken, Jonas Esche,
Danika Krupp, Stefan A. Wudy, and Thomas Remer. “Inflammatory Mediators in the
Adipo-Renal Axis: Leptin, Adiponectin, and Soluble ICAM-1.” American Journal
of Physiology-Renal Physiology, 2020, F469–75. https://doi.org/10.1152/ajprenal.00257.2020.'
ieee: 'Y. Hua et al., “Inflammatory mediators in the adipo-renal axis: leptin,
adiponectin, and soluble ICAM-1,” American Journal of Physiology-Renal Physiology,
pp. F469–F475, 2020, doi: 10.1152/ajprenal.00257.2020.'
mla: 'Hua, Yifan, et al. “Inflammatory Mediators in the Adipo-Renal Axis: Leptin,
Adiponectin, and Soluble ICAM-1.” American Journal of Physiology-Renal Physiology,
2020, pp. F469–75, doi:10.1152/ajprenal.00257.2020.'
short: Y. Hua, C. Herder, H. Kalhoff, A. Buyken, J. Esche, D. Krupp, S.A. Wudy,
T. Remer, American Journal of Physiology-Renal Physiology (2020) F469–F475.
date_created: 2021-11-25T12:09:30Z
date_updated: 2022-01-06T06:57:45Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.1152/ajprenal.00257.2020
language:
- iso: eng
page: F469-F475
publication: American Journal of Physiology-Renal Physiology
publication_identifier:
issn:
- 1931-857X
- 1522-1466
publication_status: published
status: public
title: 'Inflammatory mediators in the adipo-renal axis: leptin, adiponectin, and soluble
ICAM-1'
type: journal_article
user_id: '61597'
year: '2020'
...