---
_id: '22635'
abstract:
- lang: eng
  text: Photodynamic therapy (PDT) using TiO2 nanoparticles has become an important
    alternative treatment for different types of cancer due to their high photocatalytic
    activity and high absorption of UV-A light. To potentiate this treatment, we have
    coated commercial glass plates with TiO2 nanoparticles prepared by the sol–gel
    method (TiO2-m), which exhibit a remarkable selectivity for the irreversible trapping
    of cancer cells. The physicochemical properties of the deposited TiO2-m nanoparticle
    coatings have been characterized by a number of complementary surface-analytical
    techniques and their interaction with leukemia and healthy blood cells were investigated.
    Scanning electron and atomic force microscopy verify the formation of a compact
    layer of TiO2-m nanoparticles. The particles are predominantly in the anatase
    phase and have hydroxyl-terminated surfaces as revealed by Raman, X-ray photoelectron,
    and infrared spectroscopy, as well as X-ray diffraction. We find that lymphoblastic
    leukemia cells adhere to the TiO2-m coating and undergo amoeboid-like migration,
    whereas lymphocytic cells show distinctly weaker interactions with the coating.
    This evidences the potential of this nanomaterial coating to selectively trap
    cancer cells and renders it a promising candidate for the development of future
    prototypes of PDT devices for the treatment of leukemia and other types of cancers
    with non-adherent cells.
article_type: original
author:
- first_name: Jaime Andres
  full_name: Garcia Diosa, Jaime Andres
  last_name: Garcia Diosa
- first_name: Alejandro
  full_name: Gonzalez Orive, Alejandro
  last_name: Gonzalez Orive
- first_name: Christian
  full_name: Weinberger, Christian
  id: '11848'
  last_name: Weinberger
- first_name: Sabrina
  full_name: Schwiderek, Sabrina
  last_name: Schwiderek
- first_name: Steffen
  full_name: Knust, Steffen
  last_name: Knust
- first_name: Michael
  full_name: Tiemann, Michael
  id: '23547'
  last_name: Tiemann
  orcid: 0000-0003-1711-2722
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Adrian
  full_name: Keller, Adrian
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
- first_name: Ruben Jesus
  full_name: Camargo Amado, Ruben Jesus
  last_name: Camargo Amado
citation:
  ama: 'Garcia Diosa JA, Gonzalez Orive A, Weinberger C, et al. TiO2 nanoparticle
    coatings on glass surfaces for the selective trapping of leukemia cells from peripheral
    blood. <i>Journal of Biomedical Materials Research Part B: Applied Biomaterials</i>.
    2021;109:2142–2153. doi:<a href="https://doi.org/10.1002/jbm.b.34862">10.1002/jbm.b.34862</a>'
  apa: 'Garcia Diosa, J. A., Gonzalez Orive, A., Weinberger, C., Schwiderek, S., Knust,
    S., Tiemann, M., Grundmeier, G., Keller, A., &#38; Camargo Amado, R. J. (2021).
    TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia
    cells from peripheral blood. <i>Journal of Biomedical Materials Research Part
    B: Applied Biomaterials</i>, <i>109</i>, 2142–2153. <a href="https://doi.org/10.1002/jbm.b.34862">https://doi.org/10.1002/jbm.b.34862</a>'
  bibtex: '@article{Garcia Diosa_Gonzalez Orive_Weinberger_Schwiderek_Knust_Tiemann_Grundmeier_Keller_Camargo
    Amado_2021, title={TiO2 nanoparticle coatings on glass surfaces for the selective
    trapping of leukemia cells from peripheral blood}, volume={109}, DOI={<a href="https://doi.org/10.1002/jbm.b.34862">10.1002/jbm.b.34862</a>},
    journal={Journal of Biomedical Materials Research Part B: Applied Biomaterials},
    author={Garcia Diosa, Jaime Andres and Gonzalez Orive, Alejandro and Weinberger,
    Christian and Schwiderek, Sabrina and Knust, Steffen and Tiemann, Michael and
    Grundmeier, Guido and Keller, Adrian and Camargo Amado, Ruben Jesus}, year={2021},
    pages={2142–2153} }'
  chicago: 'Garcia Diosa, Jaime Andres, Alejandro Gonzalez Orive, Christian Weinberger,
    Sabrina Schwiderek, Steffen Knust, Michael Tiemann, Guido Grundmeier, Adrian Keller,
    and Ruben Jesus Camargo Amado. “TiO2 Nanoparticle Coatings on Glass Surfaces for
    the Selective Trapping of Leukemia Cells from Peripheral Blood.” <i>Journal of
    Biomedical Materials Research Part B: Applied Biomaterials</i> 109 (2021): 2142–2153.
    <a href="https://doi.org/10.1002/jbm.b.34862">https://doi.org/10.1002/jbm.b.34862</a>.'
  ieee: 'J. A. Garcia Diosa <i>et al.</i>, “TiO2 nanoparticle coatings on glass surfaces
    for the selective trapping of leukemia cells from peripheral blood,” <i>Journal
    of Biomedical Materials Research Part B: Applied Biomaterials</i>, vol. 109, pp.
    2142–2153, 2021, doi: <a href="https://doi.org/10.1002/jbm.b.34862">10.1002/jbm.b.34862</a>.'
  mla: 'Garcia Diosa, Jaime Andres, et al. “TiO2 Nanoparticle Coatings on Glass Surfaces
    for the Selective Trapping of Leukemia Cells from Peripheral Blood.” <i>Journal
    of Biomedical Materials Research Part B: Applied Biomaterials</i>, vol. 109, 2021,
    pp. 2142–2153, doi:<a href="https://doi.org/10.1002/jbm.b.34862">10.1002/jbm.b.34862</a>.'
  short: 'J.A. Garcia Diosa, A. Gonzalez Orive, C. Weinberger, S. Schwiderek, S. Knust,
    M. Tiemann, G. Grundmeier, A. Keller, R.J. Camargo Amado, Journal of Biomedical
    Materials Research Part B: Applied Biomaterials 109 (2021) 2142–2153.'
date_created: 2021-07-08T11:34:21Z
date_updated: 2023-03-08T08:10:25Z
department:
- _id: '302'
- _id: '307'
- _id: '35'
- _id: '2'
doi: 10.1002/jbm.b.34862
intvolume: '       109'
language:
- iso: eng
page: 2142–2153
publication: 'Journal of Biomedical Materials Research Part B: Applied Biomaterials'
publication_identifier:
  issn:
  - 1552-4973
  - 1552-4981
publication_status: published
quality_controlled: '1'
status: public
title: TiO2 nanoparticle coatings on glass surfaces for the selective trapping of
  leukemia cells from peripheral blood
type: journal_article
user_id: '23547'
volume: 109
year: '2021'
...