@article{61335, abstract = {{Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus, efficient strategies for their preparation are in great demand. Herein, a novel protocol is reported for the synthesis of amidines based on PIII/PVO redox catalysis. This two‐step, one‐pot approach involves the activation of amides via PIII/PVO catalyzed in situ formation of imidoyl chloride intermediates which are directly converted upon reaction with amines into the corresponding amidines. Instead of traditionally used toxic and corrosive chloride sources, hexachloroacetone (HCA) is successfully employed as a halide source. The reaction proceeds with low catalyst loading (2 mol%) in BuOAc as the solvent. Under the optimized conditions, 20 amidines are prepared in yields up to 99%. A feasible mechanism is proposed based on experimental results. The synthetic potential of this method is evaluated in the preparation of the tyrosine kinase inhibitor (TKI) Erlotinib.}}, author = {{Medvaric, Viktorija and Paradies, Jan and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T2, T, CSSD}}, publisher = {{Wiley}}, title = {{{Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides}}}, doi = {{10.1002/adsc.70059}}, year = {{2025}}, } @article{55371, abstract = {{AbstractThe activation of C(sp3)−F bonds by the commercially available catalyst B(C6F5)3 is reported and applied in reactions with arenes, allylic, vinylic and acetylenic silanes, and olefins to achieve a variety of C−C bond formations (45 examples).}}, author = {{Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, number = {{13}}, pages = {{2933--2938}}, publisher = {{Wiley}}, title = {{{Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds}}}, doi = {{10.1002/adsc.202400511}}, volume = {{366}}, year = {{2024}}, } @article{59616, abstract = {{AbstractThe activation of C(sp3)−F bonds by the commercially available catalyst B(C6F5)3 is reported and applied in reactions with arenes, allylic, vinylic and acetylenic silanes, and olefins to achieve a variety of C−C bond formations (45 examples).}}, author = {{Hoppe, Axel and Stepen, Arne J. and Köring, Laura and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{fluoride, bond activation, borane, Lewis acid, C-C bond formation}}, number = {{13}}, pages = {{2933--2938}}, publisher = {{Wiley}}, title = {{{Tris(pentafluorophenyl)borane‐Catalyzed Functionalization of Benzylic C−F Bonds}}}, doi = {{10.1002/adsc.202400511}}, volume = {{366}}, year = {{2024}}, } @article{35692, author = {{Sieland, Benedikt and Hoppe, Axel and Stepen, Arne J. and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{General Chemistry}}, number = {{18}}, pages = {{3143--3148}}, publisher = {{Wiley}}, title = {{{Frustrated Lewis Pair‐Catalyzed Hydroboration of Nitriles: FLP Versus Borenium Catalysis}}}, doi = {{10.1002/adsc.202200525}}, volume = {{364}}, year = {{2022}}, } @article{59619, abstract = {{AbstractA frustrated Lewis pair‐catalyzed hydroboration of aromatic and aliphatic nitriles was developed. The catalyst provides the primary amines in high yields of 77–99% with catalyst loading as low as 2 mol%. The reaction displays high functional group tolerance towards esters, amides, nitro groups and aliphatic halides. The addition of the diborylated amines to ethyl 3‐phenylpropiolate proceeds with Z‐selectivity with d.r. of >99:1 in 77–90% yield over two steps. The reaction mechanism was investigated by control and computational experiments.magnified image }}, author = {{Sieland, Benedikt and Hoppe, Axel and Stepen, Arne J. and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{hydroboration, nitrile, amine, frustrated Lewis pair, density functional theory}}, number = {{18}}, pages = {{3143--3148}}, publisher = {{Wiley}}, title = {{{Frustrated Lewis Pair‐Catalyzed Hydroboration of Nitriles: FLP Versus Borenium Catalysis}}}, doi = {{10.1002/adsc.202200525}}, volume = {{364}}, year = {{2022}}, } @article{37948, author = {{Liu, Xin and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T1, T3, CSSD}}, number = {{4}}, pages = {{1096--1104}}, publisher = {{Wiley}}, title = {{{Selective Construction of C−C and C=C Bonds by Manganese Catalyzed Coupling of Alcohols with Phosphorus Ylides}}}, doi = {{10.1002/adsc.202001209}}, volume = {{363}}, year = {{2021}}, } @article{35706, author = {{Oechsle, Peter and Hou, Peng and Flörke, Ulrich and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{General Chemistry}}, number = {{23}}, pages = {{3770--3776}}, publisher = {{Wiley}}, title = {{{Concise Synthesis of Dithiophene Derivatives by a Palladium- Catalyzed Multiple C-S Cross Coupling/Cyclization Sequence}}}, doi = {{10.1002/adsc.201600802}}, volume = {{358}}, year = {{2016}}, } @article{35708, author = {{Oechsle, Peter and Hou, Peng and Flörke, Ulrich and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{General Chemistry}}, number = {{23}}, pages = {{3656--3656}}, publisher = {{Wiley}}, title = {{{Cover Picture: Concise Synthesis of Dithiophene Derivatives by a Palladium- Catalyzed Multiple C-S Cross Coupling/Cyclization Sequence (Adv. Synth. Catal. 23/2016)}}}, doi = {{10.1002/adsc.201601149}}, volume = {{358}}, year = {{2016}}, } @article{22254, author = {{Oechsle, Peter and Hou, Peng and Flörke, Ulrich and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, pages = {{3656--3656}}, title = {{{Cover Picture: Concise Synthesis of Dithiophene Derivatives by a Palladium- Catalyzed Multiple C-S Cross Coupling/Cyclization Sequence (Adv. Synth. Catal. 23/2016)}}}, doi = {{10.1002/adsc.201601149}}, year = {{2016}}, } @article{22249, author = {{Oechsle, Peter and Hou, Peng and Flörke, Ulrich and Paradies, Jan}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, pages = {{3770--3776}}, title = {{{Concise Synthesis of Dithiophene Derivatives by a Palladium- Catalyzed Multiple C-S Cross Coupling/Cyclization Sequence}}}, doi = {{10.1002/adsc.201600802}}, year = {{2016}}, } @article{37989, author = {{Schirmer, Marie-Luis and Jopp, Stefan and Holz, Jens and Spannenberg, Anke and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T2, CSSD}}, number = {{1}}, pages = {{26--29}}, publisher = {{Wiley}}, title = {{{Organocatalyzed Reduction of Tertiary Phosphine Oxides}}}, doi = {{10.1002/adsc.201500762}}, volume = {{358}}, year = {{2016}}, } @article{37988, author = {{Desens, Willi and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{T1, CSSD}}, number = {{4}}, pages = {{622--630}}, publisher = {{Wiley}}, title = {{{Convergent Activation Concept for CO2Fixation in Carbonates}}}, doi = {{10.1002/adsc.201500941}}, volume = {{358}}, year = {{2016}}, } @article{38009, author = {{Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis & Catalysis}}, keywords = {{T2}}, number = {{10}}, pages = {{1469--1481}}, publisher = {{Wiley}}, title = {{{Phosphonium Salt Organocatalysis}}}, doi = {{10.1002/adsc.200900211}}, volume = {{351}}, year = {{2009}}, } @article{38017, author = {{Christoffers, Jens and Baro, Angelika and Werner, Thomas}}, issn = {{1615-4150}}, journal = {{Advanced Synthesis and Catalysis}}, keywords = {{General Chemistry}}, number = {{23}}, pages = {{143--151}}, publisher = {{Wiley}}, title = {{{α-Hydroxylation ofβ-Dicarbonyl Compounds}}}, doi = {{10.1002/adsc.200303140}}, volume = {{346}}, year = {{2004}}, }