---
_id: '41382'
author:
- first_name: J
  full_name: Freff, J
  last_name: Freff
- first_name: L
  full_name: Bröker, L
  last_name: Bröker
- first_name: R
  full_name: Leite Dantas, R
  last_name: Leite Dantas
- first_name: K
  full_name: Schwarte, K
  last_name: Schwarte
- first_name: J
  full_name: Bühlmeier, J
  last_name: Bühlmeier
- first_name: I
  full_name: Kraft, I
  last_name: Kraft
- first_name: A
  full_name: Hinney, A
  last_name: Hinney
- first_name: U
  full_name: Buhlmann, U
  last_name: Buhlmann
- first_name: V
  full_name: Arolt, V
  last_name: Arolt
- first_name: U
  full_name: Dannlowski, U
  last_name: Dannlowski
- first_name: G
  full_name: Romer, G
  last_name: Romer
- first_name: BT
  full_name: Baune, BT
  last_name: Baune
- first_name: J
  full_name: Hebebrand, J
  last_name: Hebebrand
- first_name: M
  full_name: Föcker, M
  last_name: Föcker
- first_name: J
  full_name: Alferink, J
  last_name: Alferink
citation:
  ama: Freff J, Bröker L, Leite Dantas R, et al. Expression of CXCR4 on CD4<sup>+</sup>
    T cells predicts body composition parameters in female adolescents with anorexia
    nervosa. <i>Front Psychiatry</i>. 2022;13:960905.
  apa: Freff, J., Bröker, L., Leite Dantas, R., Schwarte, K., Bühlmeier, J., Kraft,
    I., Hinney, A., Buhlmann, U., Arolt, V., Dannlowski, U., Romer, G., Baune, B.,
    Hebebrand, J., Föcker, M., &#38; Alferink, J. (2022). Expression of CXCR4 on CD4<sup>+</sup>
    T cells predicts body composition parameters in female adolescents with anorexia
    nervosa. <i>Front Psychiatry</i>, <i>13</i>, 960905.
  bibtex: '@article{Freff_Bröker_Leite Dantas_Schwarte_Bühlmeier_Kraft_Hinney_Buhlmann_Arolt_Dannlowski_et
    al._2022, title={Expression of CXCR4 on CD4<sup>+</sup> T cells predicts body
    composition parameters in female adolescents with anorexia nervosa.}, volume={13},
    journal={Front Psychiatry}, author={Freff, J and Bröker, L and Leite Dantas, R
    and Schwarte, K and Bühlmeier, J and Kraft, I and Hinney, A and Buhlmann, U and
    Arolt, V and Dannlowski, U and et al.}, year={2022}, pages={960905} }'
  chicago: 'Freff, J, L Bröker, R Leite Dantas, K Schwarte, J Bühlmeier, I Kraft,
    A Hinney, et al. “Expression of CXCR4 on CD4<sup>+</sup> T Cells Predicts Body
    Composition Parameters in Female Adolescents with Anorexia Nervosa.” <i>Front
    Psychiatry</i> 13 (2022): 960905.'
  ieee: J. Freff <i>et al.</i>, “Expression of CXCR4 on CD4<sup>+</sup> T cells predicts
    body composition parameters in female adolescents with anorexia nervosa.,” <i>Front
    Psychiatry</i>, vol. 13, p. 960905, 2022.
  mla: Freff, J., et al. “Expression of CXCR4 on CD4<sup>+</sup> T Cells Predicts
    Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” <i>Front
    Psychiatry</i>, vol. 13, 2022, p. 960905.
  short: J. Freff, L. Bröker, R. Leite Dantas, K. Schwarte, J. Bühlmeier, I. Kraft,
    A. Hinney, U. Buhlmann, V. Arolt, U. Dannlowski, G. Romer, B. Baune, J. Hebebrand,
    M. Föcker, J. Alferink, Front Psychiatry 13 (2022) 960905.
date_created: 2023-02-01T14:40:12Z
date_updated: 2023-02-01T14:43:41Z
external_id:
  pmid:
  - '36226111'
intvolume: '        13'
language:
- iso: eng
page: '960905'
pmid: '1'
publication: Front Psychiatry
publication_identifier:
  issn:
  - 1664-0640
status: public
title: Expression of CXCR4 on CD4<sup>+</sup> T cells predicts body composition parameters
  in female adolescents with anorexia nervosa.
type: journal_article
user_id: '89838'
volume: 13
year: '2022'
...
---
_id: '27575'
abstract:
- lang: eng
  text: <jats:p>There is a distinct increase in the prevalence of depression with
    the onset of puberty. The role of peripubertal testosterone levels in boys in
    this context is insufficiently understood and may be modulated by a functional
    polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats.
    Moreover, there is preliminary evidence that the relationship between testosterone,
    CAG repeat length, and the severity of depressive symptoms may differ between
    subclinical and overt depression, but this has neither been studied in a clinical
    sample of adolescents with depression nor compared between subclinical and overt
    depression in an adequately powered study. To investigate the relationship between
    free testosterone, CAG repeat length of the AR, depression status (subclinical
    vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or
    daycare patients at a single psychiatric hospital were studied. Of these, 73 boys
    had at least mild depressive symptoms according to the Beck Depression Inventory-II
    (BDI-II &amp;gt; 13). Higher-order moderation analysis in the multiple regression
    framework revealed a constant relationship between free testosterone and depression
    severity irrespective of the number of CAG repeats in adolescents with a BDI-II
    score ≤ 13. In adolescents with a BDI-II score &amp;gt; 13, however, there was
    a significant negative relationship between free testosterone and BDI-II score
    in patients with &amp;lt;19 CAG repeats and a significant positive relationship
    regarding free testosterone and BDI-II score in those with more than 28 CAG repeats,
    even when considering important covariates. These results suggest that the effects
    of testosterone on mood in male adolescents with depression depend on the genetic
    make-up of the AR as well as on depression status. This complex relationship should
    be considered by future studies addressing mental health issues against an endocrine
    background and may, moreover, contribute to tailored treatment concepts in psychiatric
    medicine, especially in adults.</jats:p>
author:
- first_name: Raphael
  full_name: Hirtz, Raphael
  last_name: Hirtz
- first_name: Lars
  full_name: Libuda, Lars
  id: '88682'
  last_name: Libuda
  orcid: 0000-0003-1603-3133
- first_name: Anke
  full_name: Hinney, Anke
  last_name: Hinney
- first_name: Manuel
  full_name: Föcker, Manuel
  last_name: Föcker
- first_name: Judith
  full_name: Bühlmeier, Judith
  last_name: Bühlmeier
- first_name: Paul-Martin
  full_name: Holterhus, Paul-Martin
  last_name: Holterhus
- first_name: Alexandra
  full_name: Kulle, Alexandra
  last_name: Kulle
- first_name: Cordula
  full_name: Kiewert, Cordula
  last_name: Kiewert
- first_name: Johannes
  full_name: Hebebrand, Johannes
  last_name: Hebebrand
- first_name: Corinna
  full_name: Grasemann, Corinna
  last_name: Grasemann
citation:
  ama: 'Hirtz R, Libuda L, Hinney A, et al. Size Matters: The CAG Repeat Length of
    the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity.
    <i>Frontiers in Psychiatry</i>. Published online 2021. doi:<a href="https://doi.org/10.3389/fpsyt.2021.732759">10.3389/fpsyt.2021.732759</a>'
  apa: 'Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Holterhus, P.-M.,
    Kulle, A., Kiewert, C., Hebebrand, J., &#38; Grasemann, C. (2021). Size Matters:
    The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent
    Depression Severity. <i>Frontiers in Psychiatry</i>. <a href="https://doi.org/10.3389/fpsyt.2021.732759">https://doi.org/10.3389/fpsyt.2021.732759</a>'
  bibtex: '@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Holterhus_Kulle_Kiewert_Hebebrand_Grasemann_2021,
    title={Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone,
    and Male Adolescent Depression Severity}, DOI={<a href="https://doi.org/10.3389/fpsyt.2021.732759">10.3389/fpsyt.2021.732759</a>},
    journal={Frontiers in Psychiatry}, author={Hirtz, Raphael and Libuda, Lars and
    Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin
    and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann,
    Corinna}, year={2021} }'
  chicago: 'Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier,
    Paul-Martin Holterhus, Alexandra Kulle, Cordula Kiewert, Johannes Hebebrand, and
    Corinna Grasemann. “Size Matters: The CAG Repeat Length of the Androgen Receptor
    Gene, Testosterone, and Male Adolescent Depression Severity.” <i>Frontiers in
    Psychiatry</i>, 2021. <a href="https://doi.org/10.3389/fpsyt.2021.732759">https://doi.org/10.3389/fpsyt.2021.732759</a>.'
  ieee: 'R. Hirtz <i>et al.</i>, “Size Matters: The CAG Repeat Length of the Androgen
    Receptor Gene, Testosterone, and Male Adolescent Depression Severity,” <i>Frontiers
    in Psychiatry</i>, 2021, doi: <a href="https://doi.org/10.3389/fpsyt.2021.732759">10.3389/fpsyt.2021.732759</a>.'
  mla: 'Hirtz, Raphael, et al. “Size Matters: The CAG Repeat Length of the Androgen
    Receptor Gene, Testosterone, and Male Adolescent Depression Severity.” <i>Frontiers
    in Psychiatry</i>, 2021, doi:<a href="https://doi.org/10.3389/fpsyt.2021.732759">10.3389/fpsyt.2021.732759</a>.'
  short: R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, P.-M. Holterhus,
    A. Kulle, C. Kiewert, J. Hebebrand, C. Grasemann, Frontiers in Psychiatry (2021).
date_created: 2021-11-18T19:57:38Z
date_updated: 2022-09-15T09:40:45Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.3389/fpsyt.2021.732759
extern: '1'
language:
- iso: eng
publication: Frontiers in Psychiatry
publication_identifier:
  issn:
  - 1664-0640
publication_status: published
status: public
title: 'Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone,
  and Male Adolescent Depression Severity'
type: journal_article
user_id: '89838'
year: '2021'
...