---
_id: '22646'
abstract:
- lang: eng
  text: "<jats:title>Abstract</jats:title>\r\n<jats:p>The surface-assisted hierarchical
    self-assembly of DNA origami lattices represents a versatile and straightforward
    method for the organization of functional nanoscale objects such as proteins and
    nanoparticles. Here, we demonstrate that controlling the binding and exchange
    of different monovalent and divalent cation species at the DNA-mica interface
    enables the self-assembly of highly ordered DNA origami lattices on mica surfaces.
    The development of lattice quality and order is quantified by a detailed topological
    analysis of high-speed atomic force microscopy (HS-AFM) images. We find that lattice
    formation and quality strongly depend on the monovalent cation species. Na<jats:sup>+</jats:sup>
    is more effective than Li<jats:sup>+</jats:sup> and K<jats:sup>+</jats:sup> in
    facilitating the assembly of high-quality DNA origami lattices, because it is
    replacing the divalent cations at their binding sites in the DNA backbone more
    efficiently. With regard to divalent cations, Ca<jats:sup>2+</jats:sup> can be
    displaced more easily from the backbone phosphates than Mg<jats:sup>2+</jats:sup>
    and is thus superior in guiding lattice assembly. By independently adjusting incubation
    time, DNA origami concentration, and cation species, we thus obtain a highly ordered
    DNA origami lattice with an unprecedented normalized correlation length of 8.2.
    Beyond the correlation length, we use computer vision algorithms to compute the
    time course of different topological observables that, overall, demonstrate that
    replacing MgCl<jats:sub>2</jats:sub> by CaCl<jats:sub>2</jats:sub> enables the
    synthesis of DNA origami lattices with drastically increased lattice order.</jats:p>"
author:
- first_name: Yang
  full_name: Xin, Yang
  last_name: Xin
- first_name: Salvador
  full_name: Martinez Rivadeneira, Salvador
  last_name: Martinez Rivadeneira
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Mario
  full_name: Castro, Mario
  last_name: Castro
- first_name: Adrian
  full_name: Keller, Adrian
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
citation:
  ama: Xin Y, Martinez Rivadeneira S, Grundmeier G, Castro M, Keller A. Self-assembly
    of highly ordered DNA origami lattices at solid-liquid interfaces by controlling
    cation binding and exchange. <i>Nano Research</i>. 2020;13:3142-3150. doi:<a href="https://doi.org/10.1007/s12274-020-2985-4">10.1007/s12274-020-2985-4</a>
  apa: Xin, Y., Martinez Rivadeneira, S., Grundmeier, G., Castro, M., &#38; Keller,
    A. (2020). Self-assembly of highly ordered DNA origami lattices at solid-liquid
    interfaces by controlling cation binding and exchange. <i>Nano Research</i>, <i>13</i>,
    3142–3150. <a href="https://doi.org/10.1007/s12274-020-2985-4">https://doi.org/10.1007/s12274-020-2985-4</a>
  bibtex: '@article{Xin_Martinez Rivadeneira_Grundmeier_Castro_Keller_2020, title={Self-assembly
    of highly ordered DNA origami lattices at solid-liquid interfaces by controlling
    cation binding and exchange}, volume={13}, DOI={<a href="https://doi.org/10.1007/s12274-020-2985-4">10.1007/s12274-020-2985-4</a>},
    journal={Nano Research}, author={Xin, Yang and Martinez Rivadeneira, Salvador
    and Grundmeier, Guido and Castro, Mario and Keller, Adrian}, year={2020}, pages={3142–3150}
    }'
  chicago: 'Xin, Yang, Salvador Martinez Rivadeneira, Guido Grundmeier, Mario Castro,
    and Adrian Keller. “Self-Assembly of Highly Ordered DNA Origami Lattices at Solid-Liquid
    Interfaces by Controlling Cation Binding and Exchange.” <i>Nano Research</i> 13
    (2020): 3142–50. <a href="https://doi.org/10.1007/s12274-020-2985-4">https://doi.org/10.1007/s12274-020-2985-4</a>.'
  ieee: Y. Xin, S. Martinez Rivadeneira, G. Grundmeier, M. Castro, and A. Keller,
    “Self-assembly of highly ordered DNA origami lattices at solid-liquid interfaces
    by controlling cation binding and exchange,” <i>Nano Research</i>, vol. 13, pp.
    3142–3150, 2020.
  mla: Xin, Yang, et al. “Self-Assembly of Highly Ordered DNA Origami Lattices at
    Solid-Liquid Interfaces by Controlling Cation Binding and Exchange.” <i>Nano Research</i>,
    vol. 13, 2020, pp. 3142–50, doi:<a href="https://doi.org/10.1007/s12274-020-2985-4">10.1007/s12274-020-2985-4</a>.
  short: Y. Xin, S. Martinez Rivadeneira, G. Grundmeier, M. Castro, A. Keller, Nano
    Research 13 (2020) 3142–3150.
date_created: 2021-07-08T12:01:03Z
date_updated: 2022-01-06T06:55:37Z
department:
- _id: '302'
doi: 10.1007/s12274-020-2985-4
intvolume: '        13'
language:
- iso: eng
page: 3142-3150
publication: Nano Research
publication_identifier:
  issn:
  - 1998-0124
  - 1998-0000
publication_status: published
status: public
title: Self-assembly of highly ordered DNA origami lattices at solid-liquid interfaces
  by controlling cation binding and exchange
type: journal_article
user_id: '48864'
volume: 13
year: '2020'
...