---
_id: '27018'
abstract:
- lang: eng
  text: <jats:p>Acute anorexia nervosa (AN) constitutes an extreme physiological state.
    We aimed to detect state related metabolic alterations during inpatient admission
    and upon short- and long-term weight regain. In addition, we tested the hypothesis
    that metabolite concentrations adapt to those of healthy controls (HC) after long-term
    weight regain. Thirty-five female adolescents with AN and 25 female HC were recruited.
    Based on a targeted approach 187 metabolite concentrations were detected at inpatient
    admission (T0), after short-term weight recovery (T1; half of target-weight) and
    close to target weight (T2). Pattern hunter and time course analysis were performed.
    The highest number of significant differences in metabolite concentrations (N
    = 32) were observed between HC and T1. According to the detected main pattern,
    metabolite concentrations at T2 became more similar to those of HC. The course
    of single metabolite concentrations (e.g., glutamic acid) revealed different metabolic
    subtypes within the study sample. Patients with AN after short-term weight regain
    are in a greater “metabolic imbalance” than at starvation. After long-term weight
    regain, patients reach a metabolite profile similar to HC. Our results might be
    confounded by different metabolic subtypes of patients with AN.</jats:p>
article_number: '7'
author:
- first_name: Manuel
  full_name: Föcker, Manuel
  last_name: Föcker
- first_name: Alexander
  full_name: Cecil, Alexander
  last_name: Cecil
- first_name: Cornelia
  full_name: Prehn, Cornelia
  last_name: Prehn
- first_name: Jerzy
  full_name: Adamski, Jerzy
  last_name: Adamski
- first_name: Muriel
  full_name: Albrecht, Muriel
  last_name: Albrecht
- first_name: Frederike
  full_name: Adams, Frederike
  last_name: Adams
- first_name: Anke
  full_name: Hinney, Anke
  last_name: Hinney
- first_name: Lars
  full_name: Libuda, Lars
  id: '88682'
  last_name: Libuda
  orcid: 0000-0003-1603-3133
- first_name: Judith
  full_name: Bühlmeier, Judith
  id: '89838'
  last_name: Bühlmeier
- first_name: Johannes
  full_name: Hebebrand, Johannes
  last_name: Hebebrand
- first_name: Triinu
  full_name: Peters, Triinu
  last_name: Peters
- first_name: Jochen
  full_name: Antel, Jochen
  last_name: Antel
citation:
  ama: Föcker M, Cecil A, Prehn C, et al. Evaluation of Metabolic Profiles of Patients
    with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive
    and Pattern Analysis. <i>Metabolites</i>. Published online 2020. doi:<a href="https://doi.org/10.3390/metabo11010007">10.3390/metabo11010007</a>
  apa: Föcker, M., Cecil, A., Prehn, C., Adamski, J., Albrecht, M., Adams, F., Hinney,
    A., Libuda, L., Bühlmeier, J., Hebebrand, J., Peters, T., &#38; Antel, J. (2020).
    Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient
    Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis.
    <i>Metabolites</i>, Article 7. <a href="https://doi.org/10.3390/metabo11010007">https://doi.org/10.3390/metabo11010007</a>
  bibtex: '@article{Föcker_Cecil_Prehn_Adamski_Albrecht_Adams_Hinney_Libuda_Bühlmeier_Hebebrand_et
    al._2020, title={Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa
    at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern
    Analysis}, DOI={<a href="https://doi.org/10.3390/metabo11010007">10.3390/metabo11010007</a>},
    number={7}, journal={Metabolites}, author={Föcker, Manuel and Cecil, Alexander
    and Prehn, Cornelia and Adamski, Jerzy and Albrecht, Muriel and Adams, Frederike
    and Hinney, Anke and Libuda, Lars and Bühlmeier, Judith and Hebebrand, Johannes
    and et al.}, year={2020} }'
  chicago: Föcker, Manuel, Alexander Cecil, Cornelia Prehn, Jerzy Adamski, Muriel
    Albrecht, Frederike Adams, Anke Hinney, et al. “Evaluation of Metabolic Profiles
    of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term
    Weight Regain—Descriptive and Pattern Analysis.” <i>Metabolites</i>, 2020. <a
    href="https://doi.org/10.3390/metabo11010007">https://doi.org/10.3390/metabo11010007</a>.
  ieee: 'M. Föcker <i>et al.</i>, “Evaluation of Metabolic Profiles of Patients with
    Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive
    and Pattern Analysis,” <i>Metabolites</i>, Art. no. 7, 2020, doi: <a href="https://doi.org/10.3390/metabo11010007">10.3390/metabo11010007</a>.'
  mla: Föcker, Manuel, et al. “Evaluation of Metabolic Profiles of Patients with Anorexia
    Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive
    and Pattern Analysis.” <i>Metabolites</i>, 7, 2020, doi:<a href="https://doi.org/10.3390/metabo11010007">10.3390/metabo11010007</a>.
  short: M. Föcker, A. Cecil, C. Prehn, J. Adamski, M. Albrecht, F. Adams, A. Hinney,
    L. Libuda, J. Bühlmeier, J. Hebebrand, T. Peters, J. Antel, Metabolites (2020).
date_created: 2021-11-01T18:55:25Z
date_updated: 2022-09-15T09:49:18Z
department:
- _id: '35'
- _id: '22'
- _id: '395'
doi: 10.3390/metabo11010007
extern: '1'
language:
- iso: eng
publication: Metabolites
publication_identifier:
  issn:
  - 2218-1989
publication_status: published
status: public
title: Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient
  Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis
type: journal_article
user_id: '89838'
year: '2020'
...