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The findings indicated that highly reactive aldehydes achieved conversion rates exceeding 90%, in contrast to their less reactive counterparts. Furthermore, these results were juxtaposed with previously published data derived from alternative synthetic methodologies, revealing that the continuous microfluidic reactions employing integrated organocatalysts within polymer networks exhibited significantly higher conversions with reduced reaction times (8 h) at the same temperature (50 °C). Additionally, the influence of different geometries (round, triangular, and square) of the gel dots on catalytic activity was investigated, with round and square gel dots demonstrating slightly superior performance compared with triangular gel dots, attributed to their increased surface area. Moreover, an extended reaction period of 6 days was conducted using 4-bromobenzaldehyde and acrylonitrile, resulting in a conversion rate exceeding 70%, which remained stable for 5 days before experiencing a slight decline due to product accumulation on the gel dots.","lang":"eng"}],"article_number":"14448","main_file_link":[{"url":"https://pubs.acs.org/doi/abs/10.1021/acsomega.5c09476","open_access":"1"}],"language":[{"iso":"eng"}],"doi":"10.1021/acsomega.5c09476","year":"2026","title":"Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction","author":[{"last_name":"Killi","first_name":"Naresh","full_name":"Killi, Naresh"},{"first_name":"Amit","last_name":"Kumar","full_name":"Kumar, Amit"},{"last_name":"Nebhani","first_name":"Leena","full_name":"Nebhani, Leena"},{"last_name":"Obst","first_name":"Franziska","full_name":"Obst, Franziska"},{"full_name":"Richter, Andreas","last_name":"Richter","first_name":"Andreas"},{"full_name":"Reineke Matsudo, Bernhard","last_name":"Reineke Matsudo","first_name":"Bernhard"},{"orcid":"0000-0002-8662-1101","first_name":"Thomas","last_name":"Zentgraf","full_name":"Zentgraf, Thomas","id":"30525"},{"id":"287","full_name":"Kuckling, Dirk","last_name":"Kuckling","first_name":"Dirk"}],"publication_identifier":{"issn":["2470-1343","2470-1343"]},"publication_status":"published","date_updated":"2026-03-10T08:27:15Z","article_type":"original","intvolume":"        11","oa":"1","citation":{"short":"N. Killi, A. Kumar, L. Nebhani, F. Obst, A. Richter, B. Reineke Matsudo, T. Zentgraf, D. Kuckling, ACS Omega 11 (2026).","chicago":"Killi, Naresh, Amit Kumar, Leena Nebhani, Franziska Obst, Andreas Richter, Bernhard Reineke Matsudo, Thomas Zentgraf, and Dirk Kuckling. “Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction.” <i>ACS Omega</i> 11, no. 9 (2026). <a href=\"https://doi.org/10.1021/acsomega.5c09476\">https://doi.org/10.1021/acsomega.5c09476</a>.","apa":"Killi, N., Kumar, A., Nebhani, L., Obst, F., Richter, A., Reineke Matsudo, B., Zentgraf, T., &#38; Kuckling, D. (2026). Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction. <i>ACS Omega</i>, <i>11</i>(9), Article 14448. <a href=\"https://doi.org/10.1021/acsomega.5c09476\">https://doi.org/10.1021/acsomega.5c09476</a>","ieee":"N. Killi <i>et al.</i>, “Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction,” <i>ACS Omega</i>, vol. 11, no. 9, Art. no. 14448, 2026, doi: <a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>.","ama":"Killi N, Kumar A, Nebhani L, et al. Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction. <i>ACS Omega</i>. 2026;11(9). doi:<a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>","bibtex":"@article{Killi_Kumar_Nebhani_Obst_Richter_Reineke Matsudo_Zentgraf_Kuckling_2026, title={Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction}, volume={11}, DOI={<a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>}, number={914448}, journal={ACS Omega}, publisher={American Chemical Society (ACS)}, author={Killi, Naresh and Kumar, Amit and Nebhani, Leena and Obst, Franziska and Richter, Andreas and Reineke Matsudo, Bernhard and Zentgraf, Thomas and Kuckling, Dirk}, year={2026} }","mla":"Killi, Naresh, et al. “Integrating an Organocatalyst into a Polymeric Gel Framework for the Continuous Microflow Baylis–Hillman Reaction.” <i>ACS Omega</i>, vol. 11, no. 9, 14448, American Chemical Society (ACS), 2026, doi:<a href=\"https://doi.org/10.1021/acsomega.5c09476\">10.1021/acsomega.5c09476</a>."},"quality_controlled":"1","_id":"64873","publisher":"American Chemical Society (ACS)","user_id":"30525","volume":11,"status":"public"},{"citation":{"bibtex":"@article{Jerigová_Odziomek_Lopez Salas_2022, title={“We Are Here!” Oxygen Functional Groups in Carbons for Electrochemical Applications}, volume={7}, DOI={<a href=\"https://doi.org/10.1021/acsomega.2c00639\">10.1021/acsomega.2c00639</a>}, number={14}, journal={ACS Omega}, publisher={American Chemical Society (ACS)}, author={Jerigová, Mária and Odziomek, Mateusz and Lopez Salas, Nieves}, year={2022}, pages={11544–11554} }","ama":"Jerigová M, Odziomek M, Lopez Salas N. “We Are Here!” Oxygen Functional Groups in Carbons for Electrochemical Applications. <i>ACS Omega</i>. 2022;7(14):11544-11554. doi:<a href=\"https://doi.org/10.1021/acsomega.2c00639\">10.1021/acsomega.2c00639</a>","mla":"Jerigová, Mária, et al. “‘We Are Here!’ Oxygen Functional Groups in Carbons for Electrochemical Applications.” <i>ACS Omega</i>, vol. 7, no. 14, American Chemical Society (ACS), 2022, pp. 11544–54, doi:<a href=\"https://doi.org/10.1021/acsomega.2c00639\">10.1021/acsomega.2c00639</a>.","short":"M. Jerigová, M. Odziomek, N. Lopez Salas, ACS Omega 7 (2022) 11544–11554.","chicago":"Jerigová, Mária, Mateusz Odziomek, and Nieves Lopez Salas. “‘We Are Here!’ Oxygen Functional Groups in Carbons for Electrochemical Applications.” <i>ACS Omega</i> 7, no. 14 (2022): 11544–54. <a href=\"https://doi.org/10.1021/acsomega.2c00639\">https://doi.org/10.1021/acsomega.2c00639</a>.","ieee":"M. Jerigová, M. Odziomek, and N. Lopez Salas, “‘We Are Here!’ Oxygen Functional Groups in Carbons for Electrochemical Applications,” <i>ACS Omega</i>, vol. 7, no. 14, pp. 11544–11554, 2022, doi: <a href=\"https://doi.org/10.1021/acsomega.2c00639\">10.1021/acsomega.2c00639</a>.","apa":"Jerigová, M., Odziomek, M., &#38; Lopez Salas, N. (2022). “We Are Here!” Oxygen Functional Groups in Carbons for Electrochemical Applications. <i>ACS Omega</i>, <i>7</i>(14), 11544–11554. <a href=\"https://doi.org/10.1021/acsomega.2c00639\">https://doi.org/10.1021/acsomega.2c00639</a>"},"publisher":"American Chemical Society (ACS)","_id":"40563","page":"11544-11554","volume":7,"user_id":"98120","status":"public","date_created":"2023-01-27T16:19:39Z","type":"journal_article","keyword":["General Chemical Engineering","General Chemistry"],"publication":"ACS Omega","issue":"14","language":[{"iso":"eng"}],"doi":"10.1021/acsomega.2c00639","publication_identifier":{"issn":["2470-1343","2470-1343"]},"author":[{"first_name":"Mária","last_name":"Jerigová","full_name":"Jerigová, Mária"},{"full_name":"Odziomek, Mateusz","last_name":"Odziomek","first_name":"Mateusz"},{"id":"98120","full_name":"Lopez Salas, Nieves","orcid":"https://orcid.org/0000-0002-8438-9548","last_name":"Lopez Salas","first_name":"Nieves"}],"title":"“We Are Here!” Oxygen Functional Groups in Carbons for Electrochemical Applications","year":"2022","intvolume":"         7","date_updated":"2023-01-27T16:35:38Z","publication_status":"published"},{"project":[{"_id":"52","name":"PC2: Computing Resources Provided by the Paderborn Center for Parallel Computing"}],"citation":{"mla":"Ruiz Alvarado, Isaac Azahel, and Wolf Gero Schmidt. “Water/InP(001) from Density Functional Theory.” <i>ACS Omega</i>, vol. 7, no. 23, American Chemical Society (ACS), 2022, pp. 19355–64, doi:<a href=\"https://doi.org/10.1021/acsomega.2c00948\">10.1021/acsomega.2c00948</a>.","ama":"Ruiz Alvarado IA, Schmidt WG. 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Schmidt, “Water/InP(001) from Density Functional Theory,” <i>ACS Omega</i>, vol. 7, no. 23, pp. 19355–19364, 2022, doi: <a href=\"https://doi.org/10.1021/acsomega.2c00948\">10.1021/acsomega.2c00948</a>.","short":"I.A. Ruiz Alvarado, W.G. Schmidt, ACS Omega 7 (2022) 19355–19364.","chicago":"Ruiz Alvarado, Isaac Azahel, and Wolf Gero Schmidt. “Water/InP(001) from Density Functional Theory.” <i>ACS Omega</i> 7, no. 23 (2022): 19355–64. <a href=\"https://doi.org/10.1021/acsomega.2c00948\">https://doi.org/10.1021/acsomega.2c00948</a>."},"volume":7,"user_id":"16199","_id":"37710","publisher":"American Chemical Society (ACS)","page":"19355-19364","status":"public","department":[{"_id":"15"},{"_id":"170"},{"_id":"295"},{"_id":"230"},{"_id":"35"}],"keyword":["General Chemical Engineering","General Chemistry"],"type":"journal_article","date_created":"2023-01-20T11:16:22Z","publication":"ACS Omega","issue":"23","doi":"10.1021/acsomega.2c00948","language":[{"iso":"eng"}],"intvolume":"         7","publication_status":"published","date_updated":"2023-04-20T13:59:34Z","author":[{"id":"79462","full_name":"Ruiz Alvarado, Isaac Azahel","first_name":"Isaac Azahel","last_name":"Ruiz Alvarado","orcid":"0000-0002-4710-1170"},{"id":"468","full_name":"Schmidt, Wolf Gero","last_name":"Schmidt","first_name":"Wolf Gero","orcid":"0000-0002-2717-5076"}],"publication_identifier":{"issn":["2470-1343","2470-1343"]},"year":"2022","title":"Water/InP(001) from Density Functional Theory"},{"citation":{"bibtex":"@article{Karmo_Ruiz Alvarado_Schmidt_Runge_2022, title={Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen}, volume={7}, DOI={<a href=\"https://doi.org/10.1021/acsomega.1c06019\">10.1021/acsomega.1c06019</a>}, number={6}, journal={ACS Omega}, publisher={American Chemical Society (ACS)}, author={Karmo, Marsel and Ruiz Alvarado, Isaac Azahel and Schmidt, Wolf Gero and Runge, Erich}, year={2022}, pages={5064–5068} }","ama":"Karmo M, Ruiz Alvarado IA, Schmidt WG, Runge E. Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen. <i>ACS Omega</i>. 2022;7(6):5064-5068. doi:<a href=\"https://doi.org/10.1021/acsomega.1c06019\">10.1021/acsomega.1c06019</a>","mla":"Karmo, Marsel, et al. “Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen.” <i>ACS Omega</i>, vol. 7, no. 6, American Chemical Society (ACS), 2022, pp. 5064–68, doi:<a href=\"https://doi.org/10.1021/acsomega.1c06019\">10.1021/acsomega.1c06019</a>.","short":"M. Karmo, I.A. Ruiz Alvarado, W.G. Schmidt, E. Runge, ACS Omega 7 (2022) 5064–5068.","chicago":"Karmo, Marsel, Isaac Azahel Ruiz Alvarado, Wolf Gero Schmidt, and Erich Runge. “Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen.” <i>ACS Omega</i> 7, no. 6 (2022): 5064–68. <a href=\"https://doi.org/10.1021/acsomega.1c06019\">https://doi.org/10.1021/acsomega.1c06019</a>.","ieee":"M. Karmo, I. A. Ruiz Alvarado, W. G. Schmidt, and E. Runge, “Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen,” <i>ACS Omega</i>, vol. 7, no. 6, pp. 5064–5068, 2022, doi: <a href=\"https://doi.org/10.1021/acsomega.1c06019\">10.1021/acsomega.1c06019</a>.","apa":"Karmo, M., Ruiz Alvarado, I. A., Schmidt, W. G., &#38; Runge, E. (2022). Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen. <i>ACS Omega</i>, <i>7</i>(6), 5064–5068. <a href=\"https://doi.org/10.1021/acsomega.1c06019\">https://doi.org/10.1021/acsomega.1c06019</a>"},"publisher":"American Chemical Society (ACS)","_id":"37714","page":"5064-5068","volume":7,"user_id":"16199","status":"public","date_created":"2023-01-20T11:25:13Z","department":[{"_id":"15"},{"_id":"170"},{"_id":"295"},{"_id":"230"},{"_id":"35"}],"keyword":["General Chemical Engineering","General Chemistry"],"type":"journal_article","publication":"ACS Omega","issue":"6","language":[{"iso":"eng"}],"doi":"10.1021/acsomega.1c06019","publication_identifier":{"issn":["2470-1343","2470-1343"]},"author":[{"full_name":"Karmo, Marsel","first_name":"Marsel","last_name":"Karmo"},{"orcid":"0000-0002-4710-1170","last_name":"Ruiz Alvarado","first_name":"Isaac Azahel","full_name":"Ruiz Alvarado, Isaac Azahel","id":"79462"},{"id":"468","last_name":"Schmidt","orcid":"0000-0002-2717-5076","first_name":"Wolf Gero","full_name":"Schmidt, Wolf Gero"},{"first_name":"Erich","last_name":"Runge","full_name":"Runge, Erich"}],"year":"2022","title":"Reconstructions of the As-Terminated GaAs(001) Surface Exposed to Atomic Hydrogen","intvolume":"         7","publication_status":"published","date_updated":"2023-04-20T14:31:21Z"},{"date_created":"2021-05-06T12:51:02Z","type":"journal_article","department":[{"_id":"15"},{"_id":"170"},{"_id":"295"},{"_id":"230"},{"_id":"35"}],"publication":"ACS Omega","citation":{"ieee":"I. A. Ruiz Alvarado, M. Karmo, E. Runge, and W. G. Schmidt, “InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory,” <i>ACS Omega</i>, pp. 6297–6304, 2021, doi: <a href=\"https://doi.org/10.1021/acsomega.0c06019\">10.1021/acsomega.0c06019</a>.","apa":"Ruiz Alvarado, I. A., Karmo, M., Runge, E., &#38; Schmidt, W. G. (2021). InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory. <i>ACS Omega</i>, 6297–6304. <a href=\"https://doi.org/10.1021/acsomega.0c06019\">https://doi.org/10.1021/acsomega.0c06019</a>","short":"I.A. Ruiz Alvarado, M. Karmo, E. Runge, W.G. Schmidt, ACS Omega (2021) 6297–6304.","chicago":"Ruiz Alvarado, Isaac Azahel, Marsel Karmo, Erich Runge, and Wolf Gero Schmidt. “InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory.” <i>ACS Omega</i>, 2021, 6297–6304. <a href=\"https://doi.org/10.1021/acsomega.0c06019\">https://doi.org/10.1021/acsomega.0c06019</a>.","mla":"Ruiz Alvarado, Isaac Azahel, et al. “InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory.” <i>ACS Omega</i>, 2021, pp. 6297–304, doi:<a href=\"https://doi.org/10.1021/acsomega.0c06019\">10.1021/acsomega.0c06019</a>.","bibtex":"@article{Ruiz Alvarado_Karmo_Runge_Schmidt_2021, title={InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory}, DOI={<a href=\"https://doi.org/10.1021/acsomega.0c06019\">10.1021/acsomega.0c06019</a>}, journal={ACS Omega}, author={Ruiz Alvarado, Isaac Azahel and Karmo, Marsel and Runge, Erich and Schmidt, Wolf Gero}, year={2021}, pages={6297–6304} }","ama":"Ruiz Alvarado IA, Karmo M, Runge E, Schmidt WG. InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory. <i>ACS Omega</i>. Published online 2021:6297-6304. doi:<a href=\"https://doi.org/10.1021/acsomega.0c06019\">10.1021/acsomega.0c06019</a>"},"project":[{"name":"Computing Resources Provided by the Paderborn Center for Parallel Computing","_id":"52"},{"_id":"52","name":"PC2: Computing Resources Provided by the Paderborn Center for Parallel Computing"}],"page":"6297-6304","language":[{"iso":"eng"}],"_id":"22009","doi":"10.1021/acsomega.0c06019","user_id":"16199","year":"2021","status":"public","title":"InP and AlInP(001)(2 × 4) Surface Oxidation from Density Functional Theory","publication_identifier":{"issn":["2470-1343","2470-1343"]},"author":[{"full_name":"Ruiz Alvarado, Isaac Azahel","first_name":"Isaac Azahel","last_name":"Ruiz Alvarado","orcid":"0000-0002-4710-1170","id":"79462"},{"last_name":"Karmo","first_name":"Marsel","full_name":"Karmo, Marsel"},{"full_name":"Runge, Erich","first_name":"Erich","last_name":"Runge"},{"id":"468","orcid":"0000-0002-2717-5076","last_name":"Schmidt","first_name":"Wolf Gero","full_name":"Schmidt, Wolf Gero"}],"date_updated":"2023-04-20T14:27:13Z","publication_status":"published"},{"language":[{"iso":"eng"}],"_id":"23781","page":"27043-27049","volume":5,"user_id":"22006","doi":"10.1021/acsomega.0c02076","author":[{"full_name":"Patil, Mayurkumar P.","last_name":"Patil","first_name":"Mayurkumar P."},{"last_name":"Vaidya","first_name":"Prakash D.","full_name":"Vaidya, Prakash D."},{"id":"665","full_name":"Kenig, Eugeny","first_name":"Eugeny","last_name":"Kenig"}],"publication_identifier":{"issn":["2470-1343","2470-1343"]},"title":"Kinetics of Carbon Dioxide Removal Using N-Acetylglucosamine","status":"public","year":"2020","intvolume":"         5","publication_status":"published","date_updated":"2022-01-06T06:55:59Z","date_created":"2021-09-06T09:35:14Z","department":[{"_id":"9"},{"_id":"145"}],"type":"journal_article","citation":{"short":"M.P. Patil, P.D. Vaidya, E. Kenig, ACS Omega 5 (2020) 27043–27049.","chicago":"Patil, Mayurkumar P., Prakash D. Vaidya, and Eugeny Kenig. “Kinetics of Carbon Dioxide Removal Using N-Acetylglucosamine.” <i>ACS Omega</i> 5 (2020): 27043–49. <a href=\"https://doi.org/10.1021/acsomega.0c02076\">https://doi.org/10.1021/acsomega.0c02076</a>.","apa":"Patil, M. P., Vaidya, P. D., &#38; Kenig, E. (2020). Kinetics of Carbon Dioxide Removal Using N-Acetylglucosamine. <i>ACS Omega</i>, <i>5</i>, 27043–27049. <a href=\"https://doi.org/10.1021/acsomega.0c02076\">https://doi.org/10.1021/acsomega.0c02076</a>","ieee":"M. P. Patil, P. D. Vaidya, and E. Kenig, “Kinetics of Carbon Dioxide Removal Using N-Acetylglucosamine,” <i>ACS Omega</i>, vol. 5, pp. 27043–27049, 2020, doi: <a href=\"https://doi.org/10.1021/acsomega.0c02076\">10.1021/acsomega.0c02076</a>.","ama":"Patil MP, Vaidya PD, Kenig E. 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