---
_id: '22926'
abstract:
- lang: eng
  text: <jats:p>Implant-associated infections are an increasingly severe burden on
    healthcare systems worldwide and many research activities currently focus on inhibiting
    microbial colonization of biomedically relevant surfaces. To obtain molecular-level
    understanding of the involved processes and interactions, we investigate the adsorption
    of synthetic adhesin-like peptide sequences derived from the type IV pili of the
    Pseudomonas aeruginosa strains PAK and PAO at abiotic model surfaces, i.e., Au,
    SiO2, and oxidized Ti. These peptides correspond to the sequences of the receptor-binding
    domain 128–144 of the major pilin protein, which is known to facilitate P. aeruginosa
    adhesion at biotic and abiotic surfaces. Using quartz crystal microbalance with
    dissipation monitoring (QCM-D), we find that peptide adsorption is material- as
    well as strain-dependent. At the Au surface, PAO(128–144) shows drastically stronger
    adsorption than PAK(128–144), whereas adsorption of both peptides is markedly
    reduced at the oxide surfaces with less drastic differences between the two sequences.
    These observations suggest that peptide adsorption is influenced by not only the
    peptide sequence, but also peptide conformation. Our results furthermore highlight
    the importance of molecular-level investigations to understand and ultimately
    control microbial colonization of surfaces.</jats:p>
author:
- first_name: Yu
  full_name: Yang, Yu
  last_name: Yang
- first_name: Sabrina
  full_name: Schwiderek, Sabrina
  last_name: Schwiderek
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Adrian
  full_name: Keller, Adrian
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
citation:
  ama: Yang Y, Schwiderek S, Grundmeier G, Keller A. Strain-Dependent Adsorption of
    Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. <i>Micro</i>.
    2021;1(1):129-139. doi:<a href="https://doi.org/10.3390/micro1010010">10.3390/micro1010010</a>
  apa: Yang, Y., Schwiderek, S., Grundmeier, G., &#38; Keller, A. (2021). Strain-Dependent
    Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic
    Surfaces. <i>Micro</i>, <i>1</i>(1), 129–139. <a href="https://doi.org/10.3390/micro1010010">https://doi.org/10.3390/micro1010010</a>
  bibtex: '@article{Yang_Schwiderek_Grundmeier_Keller_2021, title={Strain-Dependent
    Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic
    Surfaces}, volume={1}, DOI={<a href="https://doi.org/10.3390/micro1010010">10.3390/micro1010010</a>},
    number={1}, journal={Micro}, author={Yang, Yu and Schwiderek, Sabrina and Grundmeier,
    Guido and Keller, Adrian}, year={2021}, pages={129–139} }'
  chicago: 'Yang, Yu, Sabrina Schwiderek, Guido Grundmeier, and Adrian Keller. “Strain-Dependent
    Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic
    Surfaces.” <i>Micro</i> 1, no. 1 (2021): 129–39. <a href="https://doi.org/10.3390/micro1010010">https://doi.org/10.3390/micro1010010</a>.'
  ieee: Y. Yang, S. Schwiderek, G. Grundmeier, and A. Keller, “Strain-Dependent Adsorption
    of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces,”
    <i>Micro</i>, vol. 1, no. 1, pp. 129–139, 2021.
  mla: Yang, Yu, et al. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived
    Adhesin-like Peptides at Abiotic Surfaces.” <i>Micro</i>, vol. 1, no. 1, 2021,
    pp. 129–39, doi:<a href="https://doi.org/10.3390/micro1010010">10.3390/micro1010010</a>.
  short: Y. Yang, S. Schwiderek, G. Grundmeier, A. Keller, Micro 1 (2021) 129–139.
date_created: 2021-08-03T06:07:33Z
date_updated: 2022-01-06T06:55:43Z
department:
- _id: '302'
doi: 10.3390/micro1010010
intvolume: '         1'
issue: '1'
language:
- iso: eng
page: 129-139
publication: Micro
publication_identifier:
  issn:
  - 2673-8023
publication_status: published
status: public
title: Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like
  Peptides at Abiotic Surfaces
type: journal_article
user_id: '48864'
volume: 1
year: '2021'
...