@inproceedings{18138, abstract = {{Modern companies are nowadays confronted with an increasing demand of multiple products, where they need to perform more flexible every day. Cost-intensive decisions are to be confirmed in short times, in order to minimize risks and secure efficient production programs as well as material flows. Tools for this digital planning via simulation methods are one well established possibility to receive decision support. Nevertheless, the creation of the necessary simulation models is a complicated and error-prone process, where complexity of modeling, validation and verification depends on the used tool and its functionalities. This paper presents implemented concepts for an innovative user support in his tasks of verification and validation of simulation models during the execution of a simulation run. Time-intensive procedures like stopping simulation, parameterization and restarting within the problem analysis are simplified. So the user is able to focus on the real problem solving task.}}, author = {{Laroque, Christoph and Fischer, Matthias and Dangelmaier, Wilhelm}}, booktitle = {{European Simulation and Modelling Conference (ESM 2009)}}, publisher = {{EUROSIS-ETI}}, title = {{{Concepts for Model Verification and Validation during Simulation Runtime}}}, year = {{2009}}, } @inproceedings{1832, author = {{Lichte, Hermann S. and Weide, Jannis}}, booktitle = {{Proceedings of the Second International ICST Conference on Simulation Tools and Techniques}}, isbn = {{9789639799455}}, publisher = {{ICST}}, title = {{{Modeling obstacles in INET/Mobility framework: motivation, integration, and performance}}}, doi = {{10.4108/icst.simutools2009.5680}}, year = {{2009}}, } @inproceedings{819, author = {{Simon Lichte, Hermann and Valentin, Stefan and Karl, Holger and Aad, Imad and Widmer, J.}}, booktitle = {{Proceedings of the 12th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2009, Tenerife, Canary Islands, Spain, October 26-19, 2009}}, pages = {{54----62}}, title = {{{Analyzing space/capacity tradeoffs of cooperative wireless networks using a probabilistic model of interference}}}, doi = {{10.1145/1641804.1641817}}, year = {{2009}}, } @article{4608, author = {{Feng, Yuanhua and Heiler, Siegfried}}, issn = {{0094-9655}}, journal = {{Journal of Statistical Computation and Simulation}}, number = {{12}}, pages = {{1425--1439}}, publisher = {{Informa UK Limited}}, title = {{{A simple bootstrap bandwidth selector for local polynomial fitting}}}, doi = {{10.1080/00949650802352019}}, volume = {{79}}, year = {{2009}}, } @article{7498, author = {{Lei, Wen and Notthoff, Christian and Offer, Matthias and Meier, Cedrik and Lorke, Axel and Jagadish, Chennupati and Wieck, Andreas D.}}, issn = {{0884-2914}}, journal = {{Journal of Materials Research}}, number = {{07}}, pages = {{2179--2184}}, publisher = {{Cambridge University Press (CUP)}}, title = {{{Electron energy structure of self-assembled In(Ga)As nanostructures probed by capacitance-voltage spectroscopy and one-dimensional numerical simulation}}}, doi = {{10.1557/jmr.2009.0293}}, volume = {{24}}, year = {{2009}}, } @article{4198, abstract = {{Three-dimensional (3D) photonic crystal exhibit direction-selective transmission with respect to the center frequency of the stop gap. As a model system, the stop gap of a 3D fcc inverted-opal photonic crystal is studied in the microwave regime in detail using 3D polyamide models. The difference in the direction-selective transmittance between crystals grown in two different high symmetry directions is experimentally shown and compared to numerical simulations.}}, author = {{Üpping, J. and Miclea, P.T. and Wehrspohn, R.B. and Baumgarten, T. and Greulich-Weber, Siegmund}}, issn = {{1569-4410}}, journal = {{Photonics and Nanostructures - Fundamentals and Applications}}, number = {{2}}, pages = {{102--106}}, publisher = {{Elsevier BV}}, title = {{{Direction-selective optical transmission of 3D fcc photonic crystals in the microwave regime}}}, doi = {{10.1016/j.photonics.2009.11.002}}, volume = {{8}}, year = {{2009}}, } @article{16649, author = {{Padberg, Kathrin and Thiere, Bianca and Preis, Robert and Dellnitz, Michael}}, issn = {{1007-5704}}, journal = {{Communications in Nonlinear Science and Numerical Simulation}}, pages = {{4176--4190}}, title = {{{Local expansion concepts for detecting transport barriers in dynamical systems}}}, doi = {{10.1016/j.cnsns.2009.03.018}}, year = {{2009}}, } @inproceedings{11881, abstract = {{A combination of GPS (global positioning system) and INS (inertial navigation system) is known to provide high precision and highly robust vehicle localization. Notably during times when the GPS signal has a poor quality, e.g. due to the lack of a sufficiently large number of visible satellites, the INS, which may consist of a gyroscope and an odometer, will lead to improved positioning accuracy. In this paper we show how velocity information obtained from GSM (global system for mobile communications) signalling, rather than from a tachometer, can be used together with a gyroscope sensor to support localization in the presence of temporarily unavailable GPS data. We propose a sensor fusion system architecture and present simulation results that show the effectiveness of this approach.}}, author = {{Peschke, Sven and Bevermeier, Maik and Haeb-Umbach, Reinhold}}, booktitle = {{6th Workshop on Positioning Navigation and Communication (WPNC 2009)}}, keywords = {{cellular radio, distance measurement, global positioning system, Global Positioning System, global system for mobile communications, GPS positioning approach, GSM velocity, gyroscopes, gyroscope sensor, inertial navigation, inertial navigation system, odometer, sensor fusion system architecture, sensors}}, pages = {{195--202}}, title = {{{A GPS positioning approach exploiting GSM velocity estimates}}}, doi = {{10.1109/WPNC.2009.4907827}}, year = {{2009}}, } @article{12060, author = {{Sommer, Christoph and Dietrich, Isabel and Dressler, Falko}}, issn = {{1383-469X}}, journal = {{Mobile Networks and Applications}}, pages = {{786--801}}, title = {{{Simulation of Ad Hoc Routing Protocols using OMNeT++}}}, doi = {{10.1007/s11036-009-0174-5}}, year = {{2009}}, } @article{15241, abstract = {{In this contribution, possibilities and methods for computer-assisted design of ultrasound transducers are described. These transducers are essential for an ultrasonic sensor design, e.g. for continuous non-invasive determination of quantities that are important in process technology. To achieve technical reliability and robustness, the precise determination of all acoustic properties of the used sensor materials is of great importance. Problem-oriented modeling, numerical simulation, special optimization algorithms and improved methods for the visualization of propagating waves offer new and promising possibilities for developing ultrasonic transducers with enhanced properties.}}, author = {{Henning, Bernd and Rautenberg, Jens and Unverzagt, Carsten and Schröder, Andreas and Olfert, Sergei}}, journal = {{Journal of Measurement Science and Technology, MST}}, number = {{124012 (11pp)}}, title = {{{Computer assisted design of transducers for ultrasonic sensor systems}}}, volume = {{20}}, year = {{2009}}, } @inbook{33813, abstract = {{Today, mobile and embedded real-time systems have to cope with the migration and allocation of multiple software tasks running on top of a real-time operating system (RTOS) residing on one or several system processors. Each RTOS has to be configured towards the individual needs of the application and environment. For this, different scheduling strategies and task priorities have to be evaluated in order to keep execution and response times for a given task set. Abstract RTOS simulation is applied to analyze different parameters in early design phases. This chapter presents a SystemC RTOS library for abstract yet accurate RTOS sim- ulation, supporting modeling of preemption in the presence of prioritized and nested interrupts. After introducing basic principles of abstract RTOS simula- tion, we present our SystemC library in detail. Thereafter, we discuss related approaches and close with applications in electronic automotive systems design and some evaluations.}}, author = {{Zabel, Henning and Müller, Wolfgang and Gerstlauer, Andreas}}, booktitle = {{Hardware Dependent Software - Principles and Practice}}, editor = {{Ecker, Wolfgang and Müller, Wolfgang and Dömer, Rainer}}, isbn = {{978-1-4020-9435-4}}, keywords = {{RTOS Modelling, RTOS Simulation, SystemC, Task Scheduling, Interrupt Analysis}}, pages = {{233--260}}, publisher = {{Springer Verlag}}, title = {{{Accurate RTOS Modelling and Analysis with SystemC}}}, doi = {{10.1007/978-1-4020-9436-1_9}}, year = {{2009}}, } @article{36056, author = {{Schlegel-Matthies, Kirsten and Methfessel, Barbara and Quellmalz, Kirsten}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{25--27}}, publisher = {{Schneider-Verlag}}, title = {{{Soziale Platzierung: Weder Geld noch Bildung allein entscheiden}}}, volume = {{86}}, year = {{2009}}, } @article{36052, author = {{Schlegel-Matthies, Kirsten and Methfessel, Barbara}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{15--20}}, publisher = {{Schneider-Verlag}}, title = {{{Geld – zentraler Schlüssel für gesellschaftliche Teilhabe}}}, volume = {{86}}, year = {{2009}}, } @article{36054, author = {{Schlegel-Matthies, Kirsten and Methfessel, Barbara}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{21--24}}, title = {{{Ressourcen – Vielfalt, Zusammenwirken und Lebensqualität}}}, volume = {{86}}, year = {{2009}}, } @article{36044, author = {{Schlegel-Matthies, Kirsten}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{2}}, publisher = {{Schneider-Verlag}}, title = {{{Ressourcen – Voraussetzung für Teilhabe- und Gestaltungsmöglichkeiten}}}, volume = {{86}}, year = {{2009}}, } @article{36049, author = {{Schlegel-Matthies, Kirsten and Methfessel, Barbara}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{3--4}}, title = {{{Ressourcen im Rahmen des Haushaltshandelns}}}, volume = {{86}}, year = {{2009}}, } @article{54931, abstract = {{Proteinuria and increased renal reabsorption of NaCl characterize the nephrotic syndrome. Here, we show that protein-rich urine from nephrotic rats and from patients with nephrotic syndrome activate the epithelial sodium channel (ENaC) in cultured M-1 mouse collecting duct cells and in Xenopus laevis oocytes heterologously expressing ENaC. The activation depended on urinary serine protease activity. We identified plasmin as a urinary serine protease by matrix-assisted laser desorption/ionization time of-flight mass spectrometry. Purified plasmin activated ENaC currents, and inhibitors of plasmin abolished urinary protease activity and the ability to activate ENaC. In nephrotic syndrome, tubular urokinase-type plasminogen activator likely converts filtered plasminogen to plasmin. Consistent with this, the combined application of urokinase-type plasminogen activator and plasminogen stimulated amiloride-sensitive transepithelial sodium transport in M-1 cells and increased amiloride-sensitive whole-cell currents in Xenopus laevis oocytes heterologously expressing ENaC. Activation of ENaC by plasmin involved cleavage and release of an inhibitory peptide from the ENaC gamma subunit ectodomain. These data suggest that a defective glomerular filtration barrier allows passage of proteolytic enzymes that have the ability to activate ENaC.}}, author = {{Svenningsen, Per and Bistrup, Claus and Friis, Ulla G. and Bertog, Marko and Haerteis, Silke and Krueger, Bettina and Stubbe, Jane and Jensen, Ole Nørregaard and Thiesson, Helle C. and Uhrenholt, Torben R. and Jespersen, Bente and Jensen, Boye L. and Korbmacher, Christoph and Skøtt, Ole}}, journal = {{Journal of the American Society of Nephrology}}, number = {{2}}, pages = {{299–310}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel}}}, doi = {{10.1681/asn.2008040364}}, volume = {{20}}, year = {{2009}}, } @article{54932, abstract = {{Incubation of microvascular endothelial cells with combretastatin A-4 phosphate (CA-4P), a microtubule-destabilizing compound that preferentially targets tumor vessels, altered cell morphology and induced scattering of Golgi stacks. Concomitantly, CA-4P up-regulated connective tissue growth factor (CTGF/CCN2), a pleiotropic factor with antiangiogenic properties. In contrast to the effects of other microtubule-targeting agents such as colchicine or nocodazole, up-regulation of CTGF was only detectable in sparse cells, which were not embedded in a cell monolayer. Furthermore, CA-4P induced CTGF expression in endothelial cells, forming tube-like structures on basement membrane gels. Up-regulation of CTGF by CA-4P was dependent on Rho kinase signaling and was increased when p42/44 mitogen-activated protein kinase was inhibited. Additionally, FoxO transcription factors were identified as potent regulators of CTGF expression in endothelial cells. Activation of FoxO transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling resulted in a synergistic increase in CA-4P-mediated CTGF induction. CA-4P-mediated expression of CTGF was thus potentiated by the inhibition of kinase pathways, which are targets of novel antineoplastic drugs. Up-regulation of CTGF by low concentrations of CA-4P may thus occur in newly formed tumor vessels and contribute to the microvessel destabilization and antiangiogenic effects of CA-4P observed in vivo.}}, author = {{Samarin, Jana and Rehm, Margot and Krueger, Bettina and Waschke, Jens and Goppelt-Struebe, Margarete}}, journal = {{Molecular Cancer Research}}, number = {{2}}, pages = {{180–188}}, publisher = {{American Association for Cancer Research (AACR)}}, title = {{{Up-Regulation of Connective Tissue Growth Factor in Endothelial Cells by the Microtubule-Destabilizing Agent Combretastatin A-4}}}, doi = {{10.1158/1541-7786.mcr-08-0292}}, volume = {{7}}, year = {{2009}}, } @article{54944, abstract = {{The epithelial sodium channel (ENaC) is probably a heterotrimer with three well characterized subunits (alphabetagamma). In humans an additional delta-subunit (delta-hENaC) exists but little is known about its function. Using the Xenopus laevis oocyte expression system, we compared the functional properties of alphabetagamma- and deltabetagamma-hENaC and investigated whether deltabetagamma-hENaC can be proteolytically activated. The amiloride-sensitive ENaC whole-cell current (DeltaI(ami)) was about 11-fold larger in oocytes expressing deltabetagamma-hENaC than in oocytes expressing alphabetagamma-hENaC. The 2-fold larger single-channel Na(+) conductance of deltabetagamma-hENaC cannot explain this difference. Using a chemiluminescence assay, we demonstrated that an increased channel surface expression is also not the cause. Thus, overall channel activity of deltabetagamma-hENaC must be higher than that of alphabetagamma-hENaC. Experiments exploiting the properties of the known betaS520C mutant ENaC confirmed this conclusion. Moreover, chymotrypsin had a reduced stimulatory effect on deltabetagamma-hENaC whole-cell currents compared with its effect on alphabetagamma-hENaC whole-cell currents (2-fold versus 5-fold). This suggests that the cell surface pool of so-called near-silent channels that can be proteolytically activated is smaller for deltabetagamma-hENaC than for alphabetagamma-hENaC. Proteolytic activation of deltabetagamma-hENaC was associated with the appearance of a delta-hENaC cleavage product at the cell surface. Finally, we demonstrated that a short inhibitory 13-mer peptide corresponding to a region of the extracellular loop of human alpha-ENaC inhibited DeltaI(ami) in oocytes expressing alphabetagamma-hENaC but not in those expressing deltabetagamma-hENaC. We conclude that the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity.}}, author = {{Haerteis, Silke and Krueger, Bettina and Korbmacher, Christoph and Rauh, Robert}}, journal = {{Journal of Biological Chemistry}}, number = {{42}}, pages = {{29024–29040}}, publisher = {{American Society for Biochemistry and Molecular Biology}}, title = {{{The $\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation}}}, doi = {{10.1074/jbc.m109.018945}}, volume = {{284}}, year = {{2009}}, } @article{54938, abstract = {{The lipid environment of the epithelial sodium channel (ENaC) and its possible association with so-called lipid rafts may be relevant to its function. The aim of our study was to confirm the association of ENaC with lipid rafts and to analyze the effect of cholesterol depletion of the plasma membrane by methyl-beta-cyclodextrin (MbetaCD) on channel function and regulation. Using sucrose density gradient centrifugation we demonstrated that a significant portion of ENaC protein distributes to low density fractions thought to be typical lipid raft fractions. Importantly, cholesterol depletion of cell lysate by MbetaCD shifted ENaC to non-raft fractions of higher density. Live cell imaging demonstrated that treatment with MbetaCD largely reduced filipin staining over time, confirming cholesterol depletion of the plasma membrane. For electrophysiological studies intact oocytes were exposed to 20 mM MbetaCD for three hours. MbetaCD treatment had no consistent effect on baseline whole-cell ENaC currents. In addition to the typical single channel conductance of about 5 pS, subconductance states of ENaC were occasionally observed in patches from MbetaCD treated but not from control oocytes. Importantly, in outside-out patch clamp recordings the stimulatory effect of recombinant SGK1 in the pipette solution was essentially abolished in oocytes pretreated with MbetaCD. These results indicate that ENaC activation by cytosolic SGK1 is compromised by removing cholesterol from the plasma membrane. Thus, ENaC activation by SGK1 may require the presence of an intact lipid environment and/or of lipid rafts as signalling platform.}}, author = {{Krueger, Bettina and Haerteis, Silke and Yang, Limin and Hartner, Andrea and Rauh, Robert and Korbmacher, Christoph and Diakov, Alexei}}, journal = {{Cellular Physiology and Biochemistry}}, number = {{5-6}}, pages = {{605–618}}, publisher = {{S. Karger AG}}, title = {{{Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1}}}, doi = {{10.1159/000257516}}, volume = {{24}}, year = {{2009}}, }