@inproceedings{27093, author = {{Henkenjohann, Mark and Joppen, Robert and Köchling, Daniel and von Enzberg, Sebastian and Kühn, Arno and Dumitrescu, Roman}}, booktitle = {{Procedia CIRP}}, pages = {{21--26}}, publisher = {{Elsevier}}, title = {{{Identification and specification of standard modules in production for a material flow simulation}}}, volume = {{99}}, year = {{2021}}, } @article{27114, abstract = {{Abstract Background/objectives Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence. Subjects/methods We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9–17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (N = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m2)]) and Fat Mass Index (FMI) [kg/m2)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at <12 years, ≥12 to ≤15 years and >15 years). Results Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01–0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01–0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003–0.08). Associations were stronger for the age group ≥12 to ≤15 years (p for interaction: <0.001). No relationship was found with FFMI. Conclusions Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness. }}, author = {{Jankovic, Nicole and Schmitting, Sarah and Krüger, Bettina and Nöthlings, Ute and Buyken, Anette E. and Alexy, Ute}}, issn = {{0954-3007}}, journal = {{European Journal of Clinical Nutrition}}, title = {{{Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study}}}, doi = {{10.1038/s41430-021-01024-y}}, year = {{2021}}, } @article{27572, abstract = {{ Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. }}, author = {{Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, title = {{{Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts}}}, doi = {{10.1024/1422-4917/a000829}}, year = {{2021}}, } @article{27573, abstract = {{ Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung. }}, author = {{Libuda, Lars and Hebebrand, Johannes and Föcker, Manuel and Peters, Triinu and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, pages = {{1--10}}, title = {{{Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken}}}, doi = {{10.1024/1422-4917/a000807}}, year = {{2021}}, } @article{27574, abstract = {{In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = &lt;.001, d = 1.35, large effect size, and p = &lt;.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults.}}, author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Antel, Jochen and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{1664-2392}}, journal = {{Frontiers in Endocrinology}}, title = {{{Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression}}}, doi = {{10.3389/fendo.2021.662243}}, year = {{2021}}, } @inproceedings{27702, author = {{Helbig, Martin and Haufe, André and Beule, Felix and Aubel, Tobias and Meschut, Gerson and Jamei, Said and Fürle, Fabian and Lossau, Sebastian and Droste, Alexander and Gleich, Hennig and Kose, Kim and Sommer, Daniel and Facciotto, Silvio}}, booktitle = {{Vortrag in: automotive CAE Grand Challange}}, location = {{Hanau}}, title = {{{Modeling of adhesives in crash simulation under consideration of manufacturing processes}}}, year = {{2021}}, } @article{27746, author = {{Zhang, Xiao and Gong, Yunhui and Della Corte, Karen and Yu, Dianke and Xue, Hongmei and Shan, Shufang and Tian, Guo and Liang, Yi and Zhang, Jieyi and He, Fang and Yang, Dagang and Zhou, Rong and Bao, Wei and Buyken, Anette and Cheng, Guo}}, issn = {{0261-5614}}, journal = {{Clinical Nutrition}}, pages = {{2791--2799}}, title = {{{Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis}}}, doi = {{10.1016/j.clnu.2021.03.041}}, year = {{2021}}, } @article{27790, author = {{Nyasordzi, Juliana and Conrad, Johanna and Goletzke, Janina and Ludwig-Walz, Helena and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Hua, Yifan and Remer, Thomas and Buyken, Anette}}, issn = {{0939-4753}}, journal = {{Nutrition, Metabolism and Cardiovascular Diseases}}, pages = {{2109--2121}}, title = {{{Early life factors and their relevance for markers of cardiometabolic risk in early adulthood}}}, doi = {{10.1016/j.numecd.2021.03.024}}, year = {{2021}}, } @article{27793, abstract = {{ABSTRACT Background Reliable tables of glycemic indexes (GIs) and glycemic loads (GLs) are critical to research examining the relationship between glycemic qualities of carbohydrate in foods, diets, and health. In the 12 years since the last edition of the tables, a large amount of new data has become available. Objectives To systematically review and tabulate published and unpublished sources of reliable GI values, including an assessment of the reliability of the data. Methods This edition of the tables lists over 4000 items, a 61% increase in the number of entries compared to the 2008 edition. The data have been separated into 2 lists. The first represents more precise values derived using the methodology recommended by the International Standards Organization (∼2100 items). The second list contains values determined using less robust methods, including using limited numbers of healthy subjects or with a large SEM (∼1900 food items). Results Dairy products, legumes, pasta, and fruits were usually low-GI foods (≤55 on the 100-point glucose scale) and had consistent values around the world. Cereals and cereal products, however, including whole-grain or whole-meal versions, showed wide variation in GI values, presumably arising from variations in manufacturing methods. Breads, breakfast cereals, rice, savory snack products, and regional foods were available in high-, medium-, and low-GI versions. Most varieties of potato were high-GI foods, but specific low-GI varieties have now been identified. Conclusions The availability of new data on the GIs of foods will facilitate wider research and application of the twin concepts of GI and GL. Although the 2021 edition of the tables improves the quality and quantity of GI data available for research and clinical practice, GI testing of regional foods remains a priority. This systematic review was registered in PROSPERO as #171204. }}, author = {{Atkinson, Fiona S and Brand-Miller, Jennie C and Foster-Powell, Kaye and Buyken, Anette and Goletzke, Janina}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, pages = {{1625--1632}}, title = {{{International tables of glycemic index and glycemic load values 2021: a systematic review}}}, doi = {{10.1093/ajcn/nqab233}}, year = {{2021}}, } @article{21082, author = {{Itner, Dominik and Gravenkamp, Hauke and Dreiling, Dmitrij and Feldmann, Nadine and Henning, Bernd}}, issn = {{1617-7061}}, journal = {{PAMM}}, title = {{{Simulation of guided waves in cylinders subject to arbitrary boundary conditions for applications in material characterization}}}, doi = {{10.1002/pamm.202000232}}, year = {{2021}}, } @phdthesis{21183, abstract = {{Die präzise Kenntnis der Eigenschaften verwendeter Materialien hat große Bedeutung für den Entwurf technischer Systeme aller Art, aber auch für die Überwachung solcher Systeme im Betrieb. Für verschiedene physikalische Eigenschaften, Betriebsbedingungen und Materialklassen werden daher geeignete messtechnische Verfahren zur Materialcharakterisierung benötigt. In der vorliegenden Arbeit wird ein Verfahren zur ultraschallbasierten Charakterisierung der mechanischen Eigenschaften von homogenen und faserverstärkten thermoplastischen Polymeren unter Berücksichtigung der Richtungsabhängigkeit vorgestellt. Plattenförmige Probekörper werden dazu mittels Laser-Pulsen hoher Energie breitbandig angeregt und die resultierenden akustischen Lamb-Wellen aufgezeichnet. Auf Basis der dispersiven Eigenschaften der detektierten Wellenleitermoden werden in einem inversen Verfahren die Parameter eines linear-elastischen Materialmodells identifiziert. Darüber hinaus wird ein Verfahren zur vollständigen Charakterisierung der Richtungsabhängigkeit in orthotropen Materialien wie Faserverbundwerkstoffen unter Verwendung eines zweidimensionalen Simulationsmodells vorgestellt. Das Messverfahren wird anhand einer Untersuchungsreihe an künstlich gealterten Polymer- und Faserverbundwerkstoffen verifiziert und die Übertragbarkeit der Ergebnisse auf den quasistatischen Fall betrachtet. Im Vergleich mit den Ergebnissen mechanischer Zugversuche werden die Voraussetzungen und Einschränkungen, insbesondere durch die Annahme eines ideal-elastischen Materialmodells, diskutiert.}}, author = {{Webersen, Manuel}}, publisher = {{Universitätsbibliothek Paderborn}}, title = {{{Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall}}}, doi = {{10.17619/UNIPB/1-1088}}, year = {{2021}}, } @article{21264, abstract = {{Abstract Background Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training. Methods In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback. Results The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7). Conclusion The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development. }}, author = {{Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}}, issn = {{1743-0003}}, journal = {{Journal of NeuroEngineering and Rehabilitation}}, title = {{{Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}}}, doi = {{10.1186/s12984-021-00822-6}}, year = {{2021}}, } @misc{21564, author = {{Itner, Dominik and Gravenkamp, Hauke and Dreiling, Dmitrij and Feldmann, Nadine and Henning, Bernd}}, title = {{{On the forward simulation and cost functions for the ultrasonic material characterization of polymers }}}, year = {{2021}}, } @article{23612, author = {{Zhang, Yong and Lewis, Nicholas H. C. and Mars, Julian and Wan, Gang and Weadock, Nicholas J. and Takacs, Christopher J. and Lukatskaya, Maria R. and Steinrück, Hans-Georg and Toney, Michael F. and Tokmakoff, Andrei and Maginn, Edward J.}}, issn = {{1520-6106}}, journal = {{The Journal of Physical Chemistry B}}, pages = {{4501--4513}}, title = {{{Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies}}}, doi = {{10.1021/acs.jpcb.1c02189}}, volume = {{125}}, year = {{2021}}, } @article{22206, abstract = {{AbstractWe consider tracking control for multibody systems which are modeled using holonomic and non-holonomic constraints. Furthermore, the systems may be underactuated and contain kinematic loops and are thus described by a set of differential-algebraic equations that cannot be reformulated as ordinary differential equations in general. We propose a control strategy which combines a feedforward controller based on the servo-constraints approach with a feedback controller based on a recent funnel control design. As an important tool for both approaches, we present a new procedure to derive the internal dynamics of a multibody system. Furthermore, we present a feasible set of coordinates for the internal dynamics avoiding the effort involved with the computation of the Byrnes–Isidori form. The control design is demonstrated by a simulation for a nonlinear non-minimum phase multi-input, multi-output robotic manipulator with kinematic loop.}}, author = {{Berger, Thomas and Drücker, Svenja and Lanza, Lukas Johannes and Reis, Timo and Seifried, Robert}}, issn = {{0924-090X}}, journal = {{Nonlinear Dynamics}}, title = {{{Tracking control for underactuated non-minimum phase multibody systems}}}, doi = {{10.1007/s11071-021-06458-4}}, year = {{2021}}, } @inproceedings{22460, author = {{Bothe, Mike and Lutters, Nicole and Kenig, Eugeny}}, location = {{online-Konferenz (Leipzig)}}, publisher = {{Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung}}, title = {{{Dynamische Simulation von Gefahrensituationen bei industriellen Kreislaufprozessen am Beispiel der chemischen Absorption}}}, year = {{2021}}, } @article{22511, abstract = {{In this paper, we reconsider the well-known discrete, round-based Go-To-The-Center algorithm due to Ando, Suzuki, and Yamashita [2] for gathering n autonomous mobile robots with limited viewing range in the plane. Remarquably, this algorithm exploits the fact that during its execution, many collisions of robots occur. Such collisions are interpreted as a success because it is assumed that such collided robots behave the same from now on. This is acceptable under the assumption that each robot is represented by a single point. Otherwise, collisions should be avoided. In this paper, we consider a continuous Go-To-The-Center algorithm in which the robots continuously observe the positions of their neighbors and adapt their speed (assuming a speed limit) and direction. Our first results are time bounds of O(n2) for gathering in two dimensions Euclidean space, and Θ(n) for the one dimension. Our main contribution is the introduction and evaluation of a continuous algorithm which performs Go-To-The-Center considering only the neighbors of a robot with respect to the Gabriel subgraph of the visibility graph, i.e. Go-To-The-Gabriel-Center algorithm. We show that this modification still correctly executes gathering in one and two dimensions, with the same time bounds as above. Simulations exhibit a severe difference of the behavior of the Go-To-The-Center and the Go-To-The-Gabriel-Center algorithms: Whereas lots of collisions occur during a run of the Go-To-The-Center algorithm, typically only one, namely the final collision occurs during a run of the Go-To-The-Gabriel-Center algorithm. We can prove this “collisionless property” of the Go-To-The-Gabriel-Center algorithm for one dimension. In two-dimensional Euclidean space, we conjecture that the “collisionless property” holds for almost every initial configuration. We support our conjecture with measurements obtained from the simulation where robots execute both continuous Go-To-The-Center and Go-To-The-Gabriel-Center algorithms. }}, author = {{Li, Shouwei and Meyer auf der Heide, Friedhelm and Podlipyan, Pavel}}, issn = {{0304-3975}}, journal = {{Theoretical Computer Science}}, keywords = {{Local algorithms, Distributed algorithms, Collisionless gathering, Mobile robots, Multiagent system}}, pages = {{29--40}}, title = {{{The impact of the Gabriel subgraph of the visibility graph on the gathering of mobile autonomous robots}}}, doi = {{10.1016/j.tcs.2020.11.009}}, volume = {{852}}, year = {{2021}}, } @article{22637, abstract = {{Abstract Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers.}}, author = {{Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann, Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen, Janne A and Linko, Veikko}}, issn = {{0305-1048}}, journal = {{Nucleic Acids Research}}, pages = {{3048--3062}}, title = {{{Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release}}}, doi = {{10.1093/nar/gkab097}}, volume = {{49}}, year = {{2021}}, } @unpublished{22807, abstract = {{Photonic quantum technologies [1] with applications in quantum communication, sensing as well as quantum simulation and computing, are on the verge of becoming commercially available. One crucial building block are tailored nanoscale integratable quantum light sources, matching the specific needs of use-cases. Several different approaches to realize solid-state quantum emitters [2] with high performance [3] have been pursued. However, the properties of the emitted single photons are always defined by the individual quantum light source and despite numerous quantum emitter tuning techniques [4-7], scalability is still a major challenge. Here we show an emitter-independent method to tailor and control the properties of the single photon emission. We demonstrate a laser-controlled down-conversion process from an excited state of a quantum three-level system [8]. Starting from a biexciton state, a tunable control laser field defines a virtual state in a stimulated process. From there, spontaneous emission to the ground state leads to optically controlled single photon emission. Based on this concept, we demonstrate energy tuning of the single photon emission with a control laser field. The nature of the involved quantum states furthermore provides a unique basis for the future control of polarization and bandwidth, as predicted by theory [9,10]. Our demonstration marks an important step towards tailored single photon emission from a photonic quantum system based on quantum optical principles.}}, author = {{Jonas, B. and Heinze, D. and Schöll, E. and Kallert, P. and Langer, T. and Krehs, S. and Widhalm, A. and Jöns, K. D. and Reuter, D. and Schumacher, S. and Zrenner, Artur}}, booktitle = {{arXiv:2105.12393}}, title = {{{Nonlinear down-conversion in a single quantum dot}}}, year = {{2021}}, } @inproceedings{22927, author = {{Derrick, John and Doherty, Simon and Dongol, Brijesh and Schellhorn, Gerhard and Wehrheim, Heike}}, booktitle = {{Proceedings of the 35th International Symposium on Distributed Computing (DISC)}}, publisher = {{Schloß Dagstuhl}}, title = {{{On Strong Observational Refinement and Forward Simulation}}}, year = {{2021}}, }