--- _id: '27093' author: - first_name: Mark full_name: Henkenjohann, Mark last_name: Henkenjohann - first_name: Robert full_name: Joppen, Robert last_name: Joppen - first_name: Daniel full_name: Köchling, Daniel last_name: Köchling - first_name: Sebastian full_name: von Enzberg, Sebastian last_name: von Enzberg - first_name: Arno full_name: Kühn, Arno last_name: Kühn - first_name: Roman full_name: Dumitrescu, Roman id: '16190' last_name: Dumitrescu citation: ama: 'Henkenjohann M, Joppen R, Köchling D, von Enzberg S, Kühn A, Dumitrescu R. Identification and specification of standard modules in production for a material flow simulation. In: Procedia CIRP. Vol 99. Elsevier; 2021:21-26.' apa: Henkenjohann, M., Joppen, R., Köchling, D., von Enzberg, S., Kühn, A., & Dumitrescu, R. (2021). Identification and specification of standard modules in production for a material flow simulation. Procedia CIRP, 99, 21–26. bibtex: '@inproceedings{Henkenjohann_Joppen_Köchling_von Enzberg_Kühn_Dumitrescu_2021, title={Identification and specification of standard modules in production for a material flow simulation}, volume={99}, booktitle={Procedia CIRP}, publisher={Elsevier}, author={Henkenjohann, Mark and Joppen, Robert and Köchling, Daniel and von Enzberg, Sebastian and Kühn, Arno and Dumitrescu, Roman}, year={2021}, pages={21–26} }' chicago: Henkenjohann, Mark, Robert Joppen, Daniel Köchling, Sebastian von Enzberg, Arno Kühn, and Roman Dumitrescu. “Identification and Specification of Standard Modules in Production for a Material Flow Simulation.” In Procedia CIRP, 99:21–26. Elsevier, 2021. ieee: M. Henkenjohann, R. Joppen, D. Köchling, S. von Enzberg, A. Kühn, and R. Dumitrescu, “Identification and specification of standard modules in production for a material flow simulation,” in Procedia CIRP, 2021, vol. 99, pp. 21–26. mla: Henkenjohann, Mark, et al. “Identification and Specification of Standard Modules in Production for a Material Flow Simulation.” Procedia CIRP, vol. 99, Elsevier, 2021, pp. 21–26. short: 'M. Henkenjohann, R. Joppen, D. Köchling, S. von Enzberg, A. Kühn, R. Dumitrescu, in: Procedia CIRP, Elsevier, 2021, pp. 21–26.' date_created: 2021-11-03T09:44:17Z date_updated: 2022-01-06T06:57:33Z department: - _id: '563' intvolume: ' 99' language: - iso: eng page: 21-26 publication: Procedia CIRP publication_status: published publisher: Elsevier status: public title: Identification and specification of standard modules in production for a material flow simulation type: conference user_id: '15782' volume: 99 year: '2021' ... --- _id: '27114' abstract: - lang: eng text: "Abstract\r\n Background/objectives\r\n \ Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence.\r\n \ \r\n Subjects/methods\r\n \ We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9–17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (N = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m2)]) and Fat Mass Index (FMI) [kg/m2)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at <12 years, ≥12 to ≤15 years and >15 years).\r\n \r\n \ Results\r\n Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01–0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01–0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003–0.08). Associations were stronger for the age group ≥12 to ≤15 years (p for interaction: <0.001). No relationship was found with FFMI.\r\n \r\n \ Conclusions\r\n Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness.\r\n \ " author: - first_name: Nicole full_name: Jankovic, Nicole last_name: Jankovic - first_name: Sarah full_name: Schmitting, Sarah last_name: Schmitting - first_name: Bettina full_name: Krüger, Bettina id: '49428' last_name: Krüger orcid: 0000-0001-5351-1785 - first_name: Ute full_name: Nöthlings, Ute last_name: Nöthlings - first_name: Anette E. full_name: Buyken, Anette E. id: '65985' last_name: Buyken - first_name: Ute full_name: Alexy, Ute last_name: Alexy citation: ama: Jankovic N, Schmitting S, Krüger B, Nöthlings U, Buyken AE, Alexy U. Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study. European Journal of Clinical Nutrition. Published online 2021. doi:10.1038/s41430-021-01024-y apa: Jankovic, N., Schmitting, S., Krüger, B., Nöthlings, U., Buyken, A. E., & Alexy, U. (2021). Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study. European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-021-01024-y bibtex: '@article{Jankovic_Schmitting_Krüger_Nöthlings_Buyken_Alexy_2021, title={Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study}, DOI={10.1038/s41430-021-01024-y}, journal={European Journal of Clinical Nutrition}, author={Jankovic, Nicole and Schmitting, Sarah and Krüger, Bettina and Nöthlings, Ute and Buyken, Anette E. and Alexy, Ute}, year={2021} }' chicago: Jankovic, Nicole, Sarah Schmitting, Bettina Krüger, Ute Nöthlings, Anette E. Buyken, and Ute Alexy. “Changes in Chronotype and Social Jetlag during Adolescence and Their Association with Concurrent Changes in BMI-SDS and Body Composition, in the DONALD Study.” European Journal of Clinical Nutrition, 2021. https://doi.org/10.1038/s41430-021-01024-y. ieee: 'N. Jankovic, S. Schmitting, B. Krüger, U. Nöthlings, A. E. Buyken, and U. Alexy, “Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study,” European Journal of Clinical Nutrition, 2021, doi: 10.1038/s41430-021-01024-y.' mla: Jankovic, Nicole, et al. “Changes in Chronotype and Social Jetlag during Adolescence and Their Association with Concurrent Changes in BMI-SDS and Body Composition, in the DONALD Study.” European Journal of Clinical Nutrition, 2021, doi:10.1038/s41430-021-01024-y. short: N. Jankovic, S. Schmitting, B. Krüger, U. Nöthlings, A.E. Buyken, U. Alexy, European Journal of Clinical Nutrition (2021). date_created: 2021-11-03T12:57:29Z date_updated: 2022-01-06T06:57:35Z department: - _id: '35' - _id: '22' - _id: '571' doi: 10.1038/s41430-021-01024-y language: - iso: eng publication: European Journal of Clinical Nutrition publication_identifier: issn: - 0954-3007 - 1476-5640 publication_status: published status: public title: Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study type: journal_article user_id: '49428' year: '2021' ... --- _id: '27572' abstract: - lang: eng text: ' Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. ' author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Yiran full_name: Zheng, Yiran last_name: Zheng - first_name: Luisa S. full_name: Rajcsanyi, Luisa S. last_name: Rajcsanyi - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Anke full_name: Hinney, Anke last_name: Hinney citation: ama: Hirtz R, Zheng Y, Rajcsanyi LS, et al. Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. Published online 2021. doi:10.1024/1422-4917/a000829 apa: Hirtz, R., Zheng, Y., Rajcsanyi, L. S., Libuda, L., Antel, J., Peters, T., Hebebrand, J., & Hinney, A. (2021). Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. https://doi.org/10.1024/1422-4917/a000829 bibtex: '@article{Hirtz_Zheng_Rajcsanyi_Libuda_Antel_Peters_Hebebrand_Hinney_2021, title={Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts}, DOI={10.1024/1422-4917/a000829}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, author={Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}, year={2021} }' chicago: Hirtz, Raphael, Yiran Zheng, Luisa S. Rajcsanyi, Lars Libuda, Jochen Antel, Triinu Peters, Johannes Hebebrand, and Anke Hinney. “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021. https://doi.org/10.1024/1422-4917/a000829. ieee: 'R. Hirtz et al., “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, doi: 10.1024/1422-4917/a000829.' mla: Hirtz, Raphael, et al. “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, doi:10.1024/1422-4917/a000829. short: R. Hirtz, Y. Zheng, L.S. Rajcsanyi, L. Libuda, J. Antel, T. Peters, J. Hebebrand, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (2021). date_created: 2021-11-18T19:30:20Z date_updated: 2022-01-06T06:57:42Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.1024/1422-4917/a000829 language: - iso: ger publication: Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie publication_identifier: issn: - 1422-4917 - 1664-2880 publication_status: published status: public title: Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts type: journal_article user_id: '49428' year: '2021' ... --- _id: '27573' abstract: - lang: eng text: ' Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung. ' author: - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Anke full_name: Hinney, Anke last_name: Hinney citation: ama: Libuda L, Hebebrand J, Föcker M, Peters T, Hinney A. Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                    Zusammenhänge zwischen Ernährung und seelischer Gesundheit                    aufzudecken. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. Published online 2021:1-10. doi:10.1024/1422-4917/a000807 apa: Libuda, L., Hebebrand, J., Föcker, M., Peters, T., & Hinney, A. (2021). Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                    Zusammenhänge zwischen Ernährung und seelischer Gesundheit                    aufzudecken. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 1–10. https://doi.org/10.1024/1422-4917/a000807 bibtex: '@article{Libuda_Hebebrand_Föcker_Peters_Hinney_2021, title={Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                    Zusammenhänge zwischen Ernährung und seelischer Gesundheit                    aufzudecken}, DOI={10.1024/1422-4917/a000807}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, author={Libuda, Lars and Hebebrand, Johannes and Föcker, Manuel and Peters, Triinu and Hinney, Anke}, year={2021}, pages={1–10} }' chicago: Libuda, Lars, Johannes Hebebrand, Manuel Föcker, Triinu Peters, and Anke Hinney. “Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                    Zusammenhänge zwischen Ernährung und seelischer Gesundheit                    aufzudecken.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, 1–10. https://doi.org/10.1024/1422-4917/a000807. ieee: 'L. Libuda, J. Hebebrand, M. Föcker, T. Peters, and A. Hinney, “Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                    Zusammenhänge zwischen Ernährung und seelischer Gesundheit                    aufzudecken,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, pp. 1–10, 2021, doi: 10.1024/1422-4917/a000807.' mla: Libuda, Lars, et al. “Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                    Zusammenhänge zwischen Ernährung und seelischer Gesundheit                    aufzudecken.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, pp. 1–10, doi:10.1024/1422-4917/a000807. short: L. Libuda, J. Hebebrand, M. Föcker, T. Peters, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (2021) 1–10. date_created: 2021-11-18T19:33:20Z date_updated: 2022-01-06T06:57:42Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.1024/1422-4917/a000807 language: - iso: ger page: 1-10 publication: Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie publication_identifier: issn: - 1422-4917 - 1664-2880 publication_status: published status: public title: Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken type: journal_article user_id: '49428' year: '2021' ... --- _id: '27574' abstract: - lang: eng text: In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = &lt;.001, d = 1.35, large effect size, and p = &lt;.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults. author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Judith full_name: Bühlmeier, Judith last_name: Bühlmeier - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Paul-Martin full_name: Holterhus, Paul-Martin last_name: Holterhus - first_name: Alexandra full_name: Kulle, Alexandra last_name: Kulle - first_name: Cordula full_name: Kiewert, Cordula last_name: Kiewert - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann citation: ama: Hirtz R, Libuda L, Hinney A, et al. Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression. Frontiers in Endocrinology. Published online 2021. doi:10.3389/fendo.2021.662243 apa: Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Antel, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Hebebrand, J., & Grasemann, C. (2021). Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2021.662243 bibtex: '@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Antel_Holterhus_Kulle_Kiewert_Hebebrand_et al._2021, title={Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression}, DOI={10.3389/fendo.2021.662243}, journal={Frontiers in Endocrinology}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Antel, Jochen and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and et al.}, year={2021} }' chicago: Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Jochen Antel, Paul-Martin Holterhus, et al. “Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression.” Frontiers in Endocrinology, 2021. https://doi.org/10.3389/fendo.2021.662243. ieee: 'R. Hirtz et al., “Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression,” Frontiers in Endocrinology, 2021, doi: 10.3389/fendo.2021.662243.' mla: Hirtz, Raphael, et al. “Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression.” Frontiers in Endocrinology, 2021, doi:10.3389/fendo.2021.662243. short: R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, J. Antel, P.-M. Holterhus, A. Kulle, C. Kiewert, J. Hebebrand, C. Grasemann, Frontiers in Endocrinology (2021). date_created: 2021-11-18T19:35:06Z date_updated: 2022-01-06T06:57:42Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.3389/fendo.2021.662243 language: - iso: eng publication: Frontiers in Endocrinology publication_identifier: issn: - 1664-2392 publication_status: published status: public title: Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression type: journal_article user_id: '49428' year: '2021' ... --- _id: '27702' author: - first_name: Martin full_name: Helbig, Martin last_name: Helbig - first_name: André full_name: Haufe, André last_name: Haufe - first_name: Felix full_name: Beule, Felix id: '66192' last_name: Beule - first_name: Tobias full_name: Aubel, Tobias last_name: Aubel - first_name: Gerson full_name: Meschut, Gerson id: '32056' last_name: Meschut orcid: 0000-0002-2763-1246 - first_name: Said full_name: Jamei, Said last_name: Jamei - first_name: Fabian full_name: Fürle, Fabian last_name: Fürle - first_name: Sebastian full_name: Lossau, Sebastian last_name: Lossau - first_name: Alexander full_name: Droste, Alexander last_name: Droste - first_name: Hennig full_name: Gleich, Hennig last_name: Gleich - first_name: Kim full_name: Kose, Kim last_name: Kose - first_name: Daniel full_name: Sommer, Daniel last_name: Sommer - first_name: Silvio full_name: Facciotto, Silvio last_name: Facciotto citation: ama: 'Helbig M, Haufe A, Beule F, et al. Modeling of adhesives in crash simulation under consideration of manufacturing processes. In: Vortrag in: Automotive CAE Grand Challange. ; 2021.' apa: 'Helbig, M., Haufe, A., Beule, F., Aubel, T., Meschut, G., Jamei, S., Fürle, F., Lossau, S., Droste, A., Gleich, H., Kose, K., Sommer, D., & Facciotto, S. (2021). Modeling of adhesives in crash simulation under consideration of manufacturing processes. Vortrag in: Automotive CAE Grand Challange. automotive CAE Grand Challange, Hanau.' bibtex: '@inproceedings{Helbig_Haufe_Beule_Aubel_Meschut_Jamei_Fürle_Lossau_Droste_Gleich_et al._2021, title={Modeling of adhesives in crash simulation under consideration of manufacturing processes}, booktitle={Vortrag in: automotive CAE Grand Challange}, author={Helbig, Martin and Haufe, André and Beule, Felix and Aubel, Tobias and Meschut, Gerson and Jamei, Said and Fürle, Fabian and Lossau, Sebastian and Droste, Alexander and Gleich, Hennig and et al.}, year={2021} }' chicago: 'Helbig, Martin, André Haufe, Felix Beule, Tobias Aubel, Gerson Meschut, Said Jamei, Fabian Fürle, et al. “Modeling of Adhesives in Crash Simulation under Consideration of Manufacturing Processes.” In Vortrag in: Automotive CAE Grand Challange, 2021.' ieee: M. Helbig et al., “Modeling of adhesives in crash simulation under consideration of manufacturing processes,” presented at the automotive CAE Grand Challange, Hanau, 2021. mla: 'Helbig, Martin, et al. “Modeling of Adhesives in Crash Simulation under Consideration of Manufacturing Processes.” Vortrag in: Automotive CAE Grand Challange, 2021.' short: 'M. Helbig, A. Haufe, F. Beule, T. Aubel, G. Meschut, S. Jamei, F. Fürle, S. Lossau, A. Droste, H. Gleich, K. Kose, D. Sommer, S. Facciotto, in: Vortrag in: Automotive CAE Grand Challange, 2021.' conference: end_date: 2021-10-20 location: Hanau name: automotive CAE Grand Challange start_date: 2021-10-19 date_created: 2021-11-22T13:35:48Z date_updated: 2022-01-06T06:57:44Z department: - _id: '157' language: - iso: eng publication: 'Vortrag in: automotive CAE Grand Challange' status: public title: Modeling of adhesives in crash simulation under consideration of manufacturing processes type: conference_abstract user_id: '66192' year: '2021' ... --- _id: '27746' author: - first_name: Xiao full_name: Zhang, Xiao last_name: Zhang - first_name: Yunhui full_name: Gong, Yunhui last_name: Gong - first_name: Karen full_name: Della Corte, Karen last_name: Della Corte - first_name: Dianke full_name: Yu, Dianke last_name: Yu - first_name: Hongmei full_name: Xue, Hongmei last_name: Xue - first_name: Shufang full_name: Shan, Shufang last_name: Shan - first_name: Guo full_name: Tian, Guo last_name: Tian - first_name: Yi full_name: Liang, Yi last_name: Liang - first_name: Jieyi full_name: Zhang, Jieyi last_name: Zhang - first_name: Fang full_name: He, Fang last_name: He - first_name: Dagang full_name: Yang, Dagang last_name: Yang - first_name: Rong full_name: Zhou, Rong last_name: Zhou - first_name: Wei full_name: Bao, Wei last_name: Bao - first_name: Anette full_name: Buyken, Anette id: '65985' last_name: Buyken - first_name: Guo full_name: Cheng, Guo last_name: Cheng citation: ama: Zhang X, Gong Y, Della Corte K, et al. Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis. Clinical Nutrition. Published online 2021:2791-2799. doi:10.1016/j.clnu.2021.03.041 apa: Zhang, X., Gong, Y., Della Corte, K., Yu, D., Xue, H., Shan, S., Tian, G., Liang, Y., Zhang, J., He, F., Yang, D., Zhou, R., Bao, W., Buyken, A., & Cheng, G. (2021). Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis. Clinical Nutrition, 2791–2799. https://doi.org/10.1016/j.clnu.2021.03.041 bibtex: '@article{Zhang_Gong_Della Corte_Yu_Xue_Shan_Tian_Liang_Zhang_He_et al._2021, title={Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis}, DOI={10.1016/j.clnu.2021.03.041}, journal={Clinical Nutrition}, author={Zhang, Xiao and Gong, Yunhui and Della Corte, Karen and Yu, Dianke and Xue, Hongmei and Shan, Shufang and Tian, Guo and Liang, Yi and Zhang, Jieyi and He, Fang and et al.}, year={2021}, pages={2791–2799} }' chicago: Zhang, Xiao, Yunhui Gong, Karen Della Corte, Dianke Yu, Hongmei Xue, Shufang Shan, Guo Tian, et al. “Relevance of Dietary Glycemic Index, Glycemic Load and Fiber Intake before and during Pregnancy for the Risk of Gestational Diabetes Mellitus and Maternal Glucose Homeostasis.” Clinical Nutrition, 2021, 2791–99. https://doi.org/10.1016/j.clnu.2021.03.041. ieee: 'X. Zhang et al., “Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis,” Clinical Nutrition, pp. 2791–2799, 2021, doi: 10.1016/j.clnu.2021.03.041.' mla: Zhang, Xiao, et al. “Relevance of Dietary Glycemic Index, Glycemic Load and Fiber Intake before and during Pregnancy for the Risk of Gestational Diabetes Mellitus and Maternal Glucose Homeostasis.” Clinical Nutrition, 2021, pp. 2791–99, doi:10.1016/j.clnu.2021.03.041. short: X. Zhang, Y. Gong, K. Della Corte, D. Yu, H. Xue, S. Shan, G. Tian, Y. Liang, J. Zhang, F. He, D. Yang, R. Zhou, W. Bao, A. Buyken, G. Cheng, Clinical Nutrition (2021) 2791–2799. date_created: 2021-11-23T16:19:11Z date_updated: 2022-01-06T06:57:44Z department: - _id: '17' - _id: '22' - _id: '571' doi: 10.1016/j.clnu.2021.03.041 language: - iso: eng page: 2791-2799 publication: Clinical Nutrition publication_identifier: issn: - 0261-5614 publication_status: published status: public title: Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis type: journal_article user_id: '61597' year: '2021' ... --- _id: '27790' author: - first_name: Juliana full_name: Nyasordzi, Juliana last_name: Nyasordzi - first_name: Johanna full_name: Conrad, Johanna last_name: Conrad - first_name: Janina full_name: Goletzke, Janina last_name: Goletzke - first_name: Helena full_name: Ludwig-Walz, Helena last_name: Ludwig-Walz - first_name: Christian full_name: Herder, Christian last_name: Herder - first_name: Michael full_name: Roden, Michael last_name: Roden - first_name: Stefan A. full_name: Wudy, Stefan A. last_name: Wudy - first_name: Yifan full_name: Hua, Yifan last_name: Hua - first_name: Thomas full_name: Remer, Thomas last_name: Remer - first_name: Anette full_name: Buyken, Anette id: '65985' last_name: Buyken citation: ama: Nyasordzi J, Conrad J, Goletzke J, et al. Early life factors and their relevance for markers of cardiometabolic risk in early adulthood. Nutrition, Metabolism and Cardiovascular Diseases. Published online 2021:2109-2121. doi:10.1016/j.numecd.2021.03.024 apa: Nyasordzi, J., Conrad, J., Goletzke, J., Ludwig-Walz, H., Herder, C., Roden, M., Wudy, S. A., Hua, Y., Remer, T., & Buyken, A. (2021). Early life factors and their relevance for markers of cardiometabolic risk in early adulthood. Nutrition, Metabolism and Cardiovascular Diseases, 2109–2121. https://doi.org/10.1016/j.numecd.2021.03.024 bibtex: '@article{Nyasordzi_Conrad_Goletzke_Ludwig-Walz_Herder_Roden_Wudy_Hua_Remer_Buyken_2021, title={Early life factors and their relevance for markers of cardiometabolic risk in early adulthood}, DOI={10.1016/j.numecd.2021.03.024}, journal={Nutrition, Metabolism and Cardiovascular Diseases}, author={Nyasordzi, Juliana and Conrad, Johanna and Goletzke, Janina and Ludwig-Walz, Helena and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Hua, Yifan and Remer, Thomas and Buyken, Anette}, year={2021}, pages={2109–2121} }' chicago: Nyasordzi, Juliana, Johanna Conrad, Janina Goletzke, Helena Ludwig-Walz, Christian Herder, Michael Roden, Stefan A. Wudy, Yifan Hua, Thomas Remer, and Anette Buyken. “Early Life Factors and Their Relevance for Markers of Cardiometabolic Risk in Early Adulthood.” Nutrition, Metabolism and Cardiovascular Diseases, 2021, 2109–21. https://doi.org/10.1016/j.numecd.2021.03.024. ieee: 'J. Nyasordzi et al., “Early life factors and their relevance for markers of cardiometabolic risk in early adulthood,” Nutrition, Metabolism and Cardiovascular Diseases, pp. 2109–2121, 2021, doi: 10.1016/j.numecd.2021.03.024.' mla: Nyasordzi, Juliana, et al. “Early Life Factors and Their Relevance for Markers of Cardiometabolic Risk in Early Adulthood.” Nutrition, Metabolism and Cardiovascular Diseases, 2021, pp. 2109–21, doi:10.1016/j.numecd.2021.03.024. short: J. Nyasordzi, J. Conrad, J. Goletzke, H. Ludwig-Walz, C. Herder, M. Roden, S.A. Wudy, Y. Hua, T. Remer, A. Buyken, Nutrition, Metabolism and Cardiovascular Diseases (2021) 2109–2121. date_created: 2021-11-25T11:58:35Z date_updated: 2022-01-06T06:57:45Z department: - _id: '17' - _id: '22' - _id: '571' doi: 10.1016/j.numecd.2021.03.024 language: - iso: eng page: 2109-2121 publication: Nutrition, Metabolism and Cardiovascular Diseases publication_identifier: issn: - 0939-4753 publication_status: published status: public title: Early life factors and their relevance for markers of cardiometabolic risk in early adulthood type: journal_article user_id: '61597' year: '2021' ... --- _id: '27793' abstract: - lang: eng text: "ABSTRACT\r\n \r\n Background\r\n \ Reliable tables of glycemic indexes (GIs) and glycemic loads (GLs) are critical to research examining the relationship between glycemic qualities of carbohydrate in foods, diets, and health. In the 12 years since the last edition of the tables, a large amount of new data has become available.\r\n \ \r\n \r\n Objectives\r\n \ To systematically review and tabulate published and unpublished sources of reliable GI values, including an assessment of the reliability of the data.\r\n \r\n \r\n \ Methods\r\n This edition of the tables lists over 4000 items, a 61% increase in the number of entries compared to the 2008 edition. The data have been separated into 2 lists. The first represents more precise values derived using the methodology recommended by the International Standards Organization (∼2100 items). The second list contains values determined using less robust methods, including using limited numbers of healthy subjects or with a large SEM (∼1900 food items).\r\n \r\n \ \r\n Results\r\n \ Dairy products, legumes, pasta, and fruits were usually low-GI foods (≤55 on the 100-point glucose scale) and had consistent values around the world. Cereals and cereal products, however, including whole-grain or whole-meal versions, showed wide variation in GI values, presumably arising from variations in manufacturing methods. Breads, breakfast cereals, rice, savory snack products, and regional foods were available in high-, medium-, and low-GI versions. Most varieties of potato were high-GI foods, but specific low-GI varieties have now been identified.\r\n \r\n \r\n \ Conclusions\r\n The availability of new data on the GIs of foods will facilitate wider research and application of the twin concepts of GI and GL. Although the 2021 edition of the tables improves the quality and quantity of GI data available for research and clinical practice, GI testing of regional foods remains a priority. This systematic review was registered in PROSPERO as #171204.\r\n " author: - first_name: Fiona S full_name: Atkinson, Fiona S last_name: Atkinson - first_name: Jennie C full_name: Brand-Miller, Jennie C last_name: Brand-Miller - first_name: Kaye full_name: Foster-Powell, Kaye last_name: Foster-Powell - first_name: Anette full_name: Buyken, Anette id: '65985' last_name: Buyken - first_name: Janina full_name: Goletzke, Janina last_name: Goletzke citation: ama: 'Atkinson FS, Brand-Miller JC, Foster-Powell K, Buyken A, Goletzke J. International tables of glycemic index and glycemic load values 2021: a systematic review. The American Journal of Clinical Nutrition. Published online 2021:1625-1632. doi:10.1093/ajcn/nqab233' apa: 'Atkinson, F. S., Brand-Miller, J. C., Foster-Powell, K., Buyken, A., & Goletzke, J. (2021). International tables of glycemic index and glycemic load values 2021: a systematic review. The American Journal of Clinical Nutrition, 1625–1632. https://doi.org/10.1093/ajcn/nqab233' bibtex: '@article{Atkinson_Brand-Miller_Foster-Powell_Buyken_Goletzke_2021, title={International tables of glycemic index and glycemic load values 2021: a systematic review}, DOI={10.1093/ajcn/nqab233}, journal={The American Journal of Clinical Nutrition}, author={Atkinson, Fiona S and Brand-Miller, Jennie C and Foster-Powell, Kaye and Buyken, Anette and Goletzke, Janina}, year={2021}, pages={1625–1632} }' chicago: 'Atkinson, Fiona S, Jennie C Brand-Miller, Kaye Foster-Powell, Anette Buyken, and Janina Goletzke. “International Tables of Glycemic Index and Glycemic Load Values 2021: A Systematic Review.” The American Journal of Clinical Nutrition, 2021, 1625–32. https://doi.org/10.1093/ajcn/nqab233.' ieee: 'F. S. Atkinson, J. C. Brand-Miller, K. Foster-Powell, A. Buyken, and J. Goletzke, “International tables of glycemic index and glycemic load values 2021: a systematic review,” The American Journal of Clinical Nutrition, pp. 1625–1632, 2021, doi: 10.1093/ajcn/nqab233.' mla: 'Atkinson, Fiona S., et al. “International Tables of Glycemic Index and Glycemic Load Values 2021: A Systematic Review.” The American Journal of Clinical Nutrition, 2021, pp. 1625–32, doi:10.1093/ajcn/nqab233.' short: F.S. Atkinson, J.C. Brand-Miller, K. Foster-Powell, A. Buyken, J. Goletzke, The American Journal of Clinical Nutrition (2021) 1625–1632. date_created: 2021-11-25T12:01:37Z date_updated: 2022-01-06T06:57:45Z department: - _id: '17' - _id: '22' - _id: '571' doi: 10.1093/ajcn/nqab233 language: - iso: eng page: 1625-1632 publication: The American Journal of Clinical Nutrition publication_identifier: issn: - 0002-9165 - 1938-3207 publication_status: published status: public title: 'International tables of glycemic index and glycemic load values 2021: a systematic review' type: journal_article user_id: '61597' year: '2021' ... --- _id: '21082' author: - first_name: Dominik full_name: Itner, Dominik last_name: Itner - first_name: Hauke full_name: Gravenkamp, Hauke last_name: Gravenkamp - first_name: Dmitrij full_name: Dreiling, Dmitrij id: '32616' last_name: Dreiling - first_name: Nadine full_name: Feldmann, Nadine id: '23082' last_name: Feldmann - first_name: Bernd full_name: Henning, Bernd id: '213' last_name: Henning citation: ama: Itner D, Gravenkamp H, Dreiling D, Feldmann N, Henning B. Simulation of guided waves in cylinders subject to arbitrary boundary conditions for applications in material characterization. PAMM. 2021. doi:10.1002/pamm.202000232 apa: Itner, D., Gravenkamp, H., Dreiling, D., Feldmann, N., & Henning, B. (2021). Simulation of guided waves in cylinders subject to arbitrary boundary conditions for applications in material characterization. PAMM. https://doi.org/10.1002/pamm.202000232 bibtex: '@article{Itner_Gravenkamp_Dreiling_Feldmann_Henning_2021, title={Simulation of guided waves in cylinders subject to arbitrary boundary conditions for applications in material characterization}, DOI={10.1002/pamm.202000232}, journal={PAMM}, author={Itner, Dominik and Gravenkamp, Hauke and Dreiling, Dmitrij and Feldmann, Nadine and Henning, Bernd}, year={2021} }' chicago: Itner, Dominik, Hauke Gravenkamp, Dmitrij Dreiling, Nadine Feldmann, and Bernd Henning. “Simulation of Guided Waves in Cylinders Subject to Arbitrary Boundary Conditions for Applications in Material Characterization.” PAMM, 2021. https://doi.org/10.1002/pamm.202000232. ieee: D. Itner, H. Gravenkamp, D. Dreiling, N. Feldmann, and B. Henning, “Simulation of guided waves in cylinders subject to arbitrary boundary conditions for applications in material characterization,” PAMM, 2021. mla: Itner, Dominik, et al. “Simulation of Guided Waves in Cylinders Subject to Arbitrary Boundary Conditions for Applications in Material Characterization.” PAMM, 2021, doi:10.1002/pamm.202000232. short: D. Itner, H. Gravenkamp, D. Dreiling, N. Feldmann, B. Henning, PAMM (2021). date_created: 2021-01-26T13:52:47Z date_updated: 2022-01-06T06:54:44Z department: - _id: '49' doi: 10.1002/pamm.202000232 language: - iso: eng project: - _id: '89' grant_number: '409779252' name: Vollständige Bestimmung der akustischen Materialparameter von Polymeren publication: PAMM publication_identifier: issn: - 1617-7061 - 1617-7061 publication_status: published status: public title: Simulation of guided waves in cylinders subject to arbitrary boundary conditions for applications in material characterization type: journal_article user_id: '23082' year: '2021' ... --- _id: '21183' abstract: - lang: ger text: Die präzise Kenntnis der Eigenschaften verwendeter Materialien hat große Bedeutung für den Entwurf technischer Systeme aller Art, aber auch für die Überwachung solcher Systeme im Betrieb. Für verschiedene physikalische Eigenschaften, Betriebsbedingungen und Materialklassen werden daher geeignete messtechnische Verfahren zur Materialcharakterisierung benötigt. In der vorliegenden Arbeit wird ein Verfahren zur ultraschallbasierten Charakterisierung der mechanischen Eigenschaften von homogenen und faserverstärkten thermoplastischen Polymeren unter Berücksichtigung der Richtungsabhängigkeit vorgestellt. Plattenförmige Probekörper werden dazu mittels Laser-Pulsen hoher Energie breitbandig angeregt und die resultierenden akustischen Lamb-Wellen aufgezeichnet. Auf Basis der dispersiven Eigenschaften der detektierten Wellenleitermoden werden in einem inversen Verfahren die Parameter eines linear-elastischen Materialmodells identifiziert. Darüber hinaus wird ein Verfahren zur vollständigen Charakterisierung der Richtungsabhängigkeit in orthotropen Materialien wie Faserverbundwerkstoffen unter Verwendung eines zweidimensionalen Simulationsmodells vorgestellt. Das Messverfahren wird anhand einer Untersuchungsreihe an künstlich gealterten Polymer- und Faserverbundwerkstoffen verifiziert und die Übertragbarkeit der Ergebnisse auf den quasistatischen Fall betrachtet. Im Vergleich mit den Ergebnissen mechanischer Zugversuche werden die Voraussetzungen und Einschränkungen, insbesondere durch die Annahme eines ideal-elastischen Materialmodells, diskutiert. - lang: eng text: Precise knowledge of material properties is a great concern in the design of technical systems, and in the monitoring of such systems during operation. Therefore, metrological processes are required for materials characterisation with respect to specific physical properties, operational conditions and classes of materials. In the work presented herein, a measurement procedure for the ultrasonic characterization of mechanical properties of homogeneous and fiber-reinforced thermoplastic polymer materials is presented, considering the different degrees of anisotropy. For this, acoustic Lamb waves are excited in a plate-shaped specimen using high-energy laser pulses, and then recorded.Based on the dispersive characteristics of the detected waveguide modes, an inverse procedure is applied to identify the parameters of a linear-elastic material model. Further, a procedure for completely characterising the orthotropy of materials like fiber-reinforced composites using a two-dimensional simulation model is presented. The measurement procedure is verified by examining artificially aged homogeneous polymers and composites, also considering the applicability of results to the quasistatic case. Comparing to the results of corresponding mechanical tensile tests, preconditions and limitations of the procedure are discussed, specifically regarding the assumption of an ideal-elastic material model. author: - first_name: Manuel full_name: Webersen, Manuel id: '11289' last_name: Webersen orcid: 0000-0001-6411-4232 citation: ama: Webersen M. Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall. Universitätsbibliothek Paderborn; 2021. doi:10.17619/UNIPB/1-1088 apa: Webersen, M. (2021). Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall. Universitätsbibliothek Paderborn. https://doi.org/10.17619/UNIPB/1-1088 bibtex: '@book{Webersen_2021, title={Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall}, DOI={10.17619/UNIPB/1-1088}, publisher={Universitätsbibliothek Paderborn}, author={Webersen, Manuel}, year={2021} }' chicago: Webersen, Manuel. Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall. Universitätsbibliothek Paderborn, 2021. https://doi.org/10.17619/UNIPB/1-1088. ieee: M. Webersen, Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall. Universitätsbibliothek Paderborn, 2021. mla: Webersen, Manuel. Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall. Universitätsbibliothek Paderborn, 2021, doi:10.17619/UNIPB/1-1088. short: M. Webersen, Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall, Universitätsbibliothek Paderborn, 2021. date_created: 2021-02-05T11:47:28Z date_updated: 2022-01-06T06:54:49Z department: - _id: '49' doi: 10.17619/UNIPB/1-1088 language: - iso: ger publication_status: published publisher: Universitätsbibliothek Paderborn status: public title: Zerstörungsfreie Charakterisierung der elastischen Materialeigenschaften thermoplastischer Polymerwerkstoffe mittels Ultraschall type: dissertation user_id: '11289' year: '2021' ... --- _id: '21264' abstract: - lang: eng text: |- Abstract Background Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training. Methods In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback. Results The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7). Conclusion The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development. author: - first_name: Alexander full_name: Boschmann, Alexander last_name: Boschmann - first_name: Dorothee full_name: Neuhaus, Dorothee last_name: Neuhaus - first_name: Sarah full_name: Vogt, Sarah last_name: Vogt - first_name: Christian full_name: Kaltschmidt, Christian last_name: Kaltschmidt - first_name: Marco full_name: Platzner, Marco last_name: Platzner - first_name: Strahinja full_name: Dosen, Strahinja last_name: Dosen citation: ama: Boschmann A, Neuhaus D, Vogt S, Kaltschmidt C, Platzner M, Dosen S. Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis. Journal of NeuroEngineering and Rehabilitation. 2021. doi:10.1186/s12984-021-00822-6 apa: Boschmann, A., Neuhaus, D., Vogt, S., Kaltschmidt, C., Platzner, M., & Dosen, S. (2021). Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis. Journal of NeuroEngineering and Rehabilitation. https://doi.org/10.1186/s12984-021-00822-6 bibtex: '@article{Boschmann_Neuhaus_Vogt_Kaltschmidt_Platzner_Dosen_2021, title={Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}, DOI={10.1186/s12984-021-00822-6}, journal={Journal of NeuroEngineering and Rehabilitation}, author={Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}, year={2021} }' chicago: Boschmann, Alexander, Dorothee Neuhaus, Sarah Vogt, Christian Kaltschmidt, Marco Platzner, and Strahinja Dosen. “Immersive Augmented Reality System for the Training of Pattern Classification Control with a Myoelectric Prosthesis.” Journal of NeuroEngineering and Rehabilitation, 2021. https://doi.org/10.1186/s12984-021-00822-6. ieee: A. Boschmann, D. Neuhaus, S. Vogt, C. Kaltschmidt, M. Platzner, and S. Dosen, “Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis,” Journal of NeuroEngineering and Rehabilitation, 2021. mla: Boschmann, Alexander, et al. “Immersive Augmented Reality System for the Training of Pattern Classification Control with a Myoelectric Prosthesis.” Journal of NeuroEngineering and Rehabilitation, 2021, doi:10.1186/s12984-021-00822-6. short: A. Boschmann, D. Neuhaus, S. Vogt, C. Kaltschmidt, M. Platzner, S. Dosen, Journal of NeuroEngineering and Rehabilitation (2021). date_created: 2021-02-22T10:43:02Z date_updated: 2022-01-06T06:54:52Z doi: 10.1186/s12984-021-00822-6 language: - iso: eng publication: Journal of NeuroEngineering and Rehabilitation publication_identifier: issn: - 1743-0003 publication_status: published status: public title: Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis type: journal_article user_id: '35756' year: '2021' ... --- _id: '21564' author: - first_name: Dominik full_name: Itner, Dominik last_name: Itner - first_name: Hauke full_name: Gravenkamp, Hauke last_name: Gravenkamp - first_name: Dmitrij full_name: Dreiling, Dmitrij id: '32616' last_name: Dreiling - first_name: Nadine full_name: Feldmann, Nadine id: '23082' last_name: Feldmann - first_name: Bernd full_name: Henning, Bernd id: '213' last_name: Henning citation: ama: Itner D, Gravenkamp H, Dreiling D, Feldmann N, Henning B. On the Forward Simulation and Cost Functions for the Ultrasonic Material Characterization of Polymers . GAMM Annual Meeting, Kassel; 2021. apa: Itner, D., Gravenkamp, H., Dreiling, D., Feldmann, N., & Henning, B. (2021). On the forward simulation and cost functions for the ultrasonic material characterization of polymers . GAMM Annual Meeting, Kassel. bibtex: '@book{Itner_Gravenkamp_Dreiling_Feldmann_Henning_2021, place={GAMM Annual Meeting, Kassel}, title={On the forward simulation and cost functions for the ultrasonic material characterization of polymers }, author={Itner, Dominik and Gravenkamp, Hauke and Dreiling, Dmitrij and Feldmann, Nadine and Henning, Bernd}, year={2021} }' chicago: Itner, Dominik, Hauke Gravenkamp, Dmitrij Dreiling, Nadine Feldmann, and Bernd Henning. On the Forward Simulation and Cost Functions for the Ultrasonic Material Characterization of Polymers . GAMM Annual Meeting, Kassel, 2021. ieee: D. Itner, H. Gravenkamp, D. Dreiling, N. Feldmann, and B. Henning, On the forward simulation and cost functions for the ultrasonic material characterization of polymers . GAMM Annual Meeting, Kassel, 2021. mla: Itner, Dominik, et al. On the Forward Simulation and Cost Functions for the Ultrasonic Material Characterization of Polymers . 2021. short: D. Itner, H. Gravenkamp, D. Dreiling, N. Feldmann, B. Henning, On the Forward Simulation and Cost Functions for the Ultrasonic Material Characterization of Polymers , GAMM Annual Meeting, Kassel, 2021. date_created: 2021-03-24T13:37:38Z date_updated: 2022-01-06T06:55:06Z department: - _id: '49' language: - iso: eng place: GAMM Annual Meeting, Kassel project: - _id: '89' grant_number: '409779252' name: Vollständige Bestimmung der akustischen Materialparameter von Polymeren status: public title: 'On the forward simulation and cost functions for the ultrasonic material characterization of polymers ' type: misc user_id: '11829' year: '2021' ... --- _id: '23612' author: - first_name: Yong full_name: Zhang, Yong last_name: Zhang - first_name: Nicholas H. C. full_name: Lewis, Nicholas H. C. last_name: Lewis - first_name: Julian full_name: Mars, Julian last_name: Mars - first_name: Gang full_name: Wan, Gang last_name: Wan - first_name: Nicholas J. full_name: Weadock, Nicholas J. last_name: Weadock - first_name: Christopher J. full_name: Takacs, Christopher J. last_name: Takacs - first_name: Maria R. full_name: Lukatskaya, Maria R. last_name: Lukatskaya - first_name: Hans-Georg full_name: Steinrück, Hans-Georg id: '84268' last_name: Steinrück orcid: 0000-0001-6373-0877 - first_name: Michael F. full_name: Toney, Michael F. last_name: Toney - first_name: Andrei full_name: Tokmakoff, Andrei last_name: Tokmakoff - first_name: Edward J. full_name: Maginn, Edward J. last_name: Maginn citation: ama: Zhang Y, Lewis NHC, Mars J, et al. Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies. The Journal of Physical Chemistry B. 2021;125:4501-4513. doi:10.1021/acs.jpcb.1c02189 apa: Zhang, Y., Lewis, N. H. C., Mars, J., Wan, G., Weadock, N. J., Takacs, C. J., Lukatskaya, M. R., Steinrück, H.-G., Toney, M. F., Tokmakoff, A., & Maginn, E. J. (2021). Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies. The Journal of Physical Chemistry B, 125, 4501–4513. https://doi.org/10.1021/acs.jpcb.1c02189 bibtex: '@article{Zhang_Lewis_Mars_Wan_Weadock_Takacs_Lukatskaya_Steinrück_Toney_Tokmakoff_et al._2021, title={Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies}, volume={125}, DOI={10.1021/acs.jpcb.1c02189}, journal={The Journal of Physical Chemistry B}, author={Zhang, Yong and Lewis, Nicholas H. C. and Mars, Julian and Wan, Gang and Weadock, Nicholas J. and Takacs, Christopher J. and Lukatskaya, Maria R. and Steinrück, Hans-Georg and Toney, Michael F. and Tokmakoff, Andrei and et al.}, year={2021}, pages={4501–4513} }' chicago: 'Zhang, Yong, Nicholas H. C. Lewis, Julian Mars, Gang Wan, Nicholas J. Weadock, Christopher J. Takacs, Maria R. Lukatskaya, et al. “Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies.” The Journal of Physical Chemistry B 125 (2021): 4501–13. https://doi.org/10.1021/acs.jpcb.1c02189.' ieee: 'Y. Zhang et al., “Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies,” The Journal of Physical Chemistry B, vol. 125, pp. 4501–4513, 2021, doi: 10.1021/acs.jpcb.1c02189.' mla: Zhang, Yong, et al. “Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies.” The Journal of Physical Chemistry B, vol. 125, 2021, pp. 4501–13, doi:10.1021/acs.jpcb.1c02189. short: Y. Zhang, N.H.C. Lewis, J. Mars, G. Wan, N.J. Weadock, C.J. Takacs, M.R. Lukatskaya, H.-G. Steinrück, M.F. Toney, A. Tokmakoff, E.J. Maginn, The Journal of Physical Chemistry B 125 (2021) 4501–4513. date_created: 2021-09-01T09:09:26Z date_updated: 2022-01-06T06:55:57Z department: - _id: '633' doi: 10.1021/acs.jpcb.1c02189 intvolume: ' 125' language: - iso: eng page: 4501-4513 publication: The Journal of Physical Chemistry B publication_identifier: issn: - 1520-6106 - 1520-5207 publication_status: published status: public title: Water-in-Salt LiTFSI Aqueous Electrolytes. 1. Liquid Structure from Combined Molecular Dynamics Simulation and Experimental Studies type: journal_article user_id: '84268' volume: 125 year: '2021' ... --- _id: '22206' abstract: - lang: eng text: AbstractWe consider tracking control for multibody systems which are modeled using holonomic and non-holonomic constraints. Furthermore, the systems may be underactuated and contain kinematic loops and are thus described by a set of differential-algebraic equations that cannot be reformulated as ordinary differential equations in general. We propose a control strategy which combines a feedforward controller based on the servo-constraints approach with a feedback controller based on a recent funnel control design. As an important tool for both approaches, we present a new procedure to derive the internal dynamics of a multibody system. Furthermore, we present a feasible set of coordinates for the internal dynamics avoiding the effort involved with the computation of the Byrnes–Isidori form. The control design is demonstrated by a simulation for a nonlinear non-minimum phase multi-input, multi-output robotic manipulator with kinematic loop. author: - first_name: Thomas full_name: Berger, Thomas last_name: Berger - first_name: Svenja full_name: Drücker, Svenja last_name: Drücker - first_name: Lukas Johannes full_name: Lanza, Lukas Johannes id: '78640' last_name: Lanza - first_name: Timo full_name: Reis, Timo last_name: Reis - first_name: Robert full_name: Seifried, Robert last_name: Seifried citation: ama: Berger T, Drücker S, Lanza LJ, Reis T, Seifried R. Tracking control for underactuated non-minimum phase multibody systems. Nonlinear Dynamics. 2021. doi:10.1007/s11071-021-06458-4 apa: Berger, T., Drücker, S., Lanza, L. J., Reis, T., & Seifried, R. (2021). Tracking control for underactuated non-minimum phase multibody systems. Nonlinear Dynamics. https://doi.org/10.1007/s11071-021-06458-4 bibtex: '@article{Berger_Drücker_Lanza_Reis_Seifried_2021, title={Tracking control for underactuated non-minimum phase multibody systems}, DOI={10.1007/s11071-021-06458-4}, journal={Nonlinear Dynamics}, author={Berger, Thomas and Drücker, Svenja and Lanza, Lukas Johannes and Reis, Timo and Seifried, Robert}, year={2021} }' chicago: Berger, Thomas, Svenja Drücker, Lukas Johannes Lanza, Timo Reis, and Robert Seifried. “Tracking Control for Underactuated Non-Minimum Phase Multibody Systems.” Nonlinear Dynamics, 2021. https://doi.org/10.1007/s11071-021-06458-4. ieee: T. Berger, S. Drücker, L. J. Lanza, T. Reis, and R. Seifried, “Tracking control for underactuated non-minimum phase multibody systems,” Nonlinear Dynamics, 2021. mla: Berger, Thomas, et al. “Tracking Control for Underactuated Non-Minimum Phase Multibody Systems.” Nonlinear Dynamics, 2021, doi:10.1007/s11071-021-06458-4. short: T. Berger, S. Drücker, L.J. Lanza, T. Reis, R. Seifried, Nonlinear Dynamics (2021). date_created: 2021-05-17T05:24:00Z date_updated: 2022-01-06T06:55:29Z doi: 10.1007/s11071-021-06458-4 language: - iso: eng publication: Nonlinear Dynamics publication_identifier: issn: - 0924-090X - 1573-269X publication_status: published status: public title: Tracking control for underactuated non-minimum phase multibody systems type: journal_article user_id: '78640' year: '2021' ... --- _id: '22460' author: - first_name: Mike full_name: Bothe, Mike id: '72973' last_name: Bothe - first_name: Nicole full_name: Lutters, Nicole id: '22006' last_name: Lutters - first_name: Eugeny full_name: Kenig, Eugeny id: '665' last_name: Kenig citation: ama: 'Bothe M, Lutters N, Kenig E. Dynamische Simulation von Gefahrensituationen bei industriellen Kreislaufprozessen am Beispiel der chemischen Absorption. In: Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung; 2021.' apa: Bothe, M., Lutters, N., & Kenig, E. (2021). Dynamische Simulation von Gefahrensituationen bei industriellen Kreislaufprozessen am Beispiel der chemischen Absorption. Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung, online-Konferenz (Leipzig). bibtex: '@inproceedings{Bothe_Lutters_Kenig_2021, place={online (Leipzig)}, title={Dynamische Simulation von Gefahrensituationen bei industriellen Kreislaufprozessen am Beispiel der chemischen Absorption}, publisher={Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung}, author={Bothe, Mike and Lutters, Nicole and Kenig, Eugeny}, year={2021} }' chicago: 'Bothe, Mike, Nicole Lutters, and Eugeny Kenig. “Dynamische Simulation von Gefahrensituationen Bei Industriellen Kreislaufprozessen Am Beispiel Der Chemischen Absorption.” online (Leipzig): Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung, 2021.' ieee: M. Bothe, N. Lutters, and E. Kenig, “Dynamische Simulation von Gefahrensituationen bei industriellen Kreislaufprozessen am Beispiel der chemischen Absorption,” presented at the Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung, online-Konferenz (Leipzig), 2021. mla: Bothe, Mike, et al. Dynamische Simulation von Gefahrensituationen Bei Industriellen Kreislaufprozessen Am Beispiel Der Chemischen Absorption. Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung, 2021. short: 'M. Bothe, N. Lutters, E. Kenig, in: Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung, online (Leipzig), 2021.' conference: end_date: 2021-02-26 location: online-Konferenz (Leipzig) name: Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung start_date: 2021-02-24 date_created: 2021-06-17T08:01:25Z date_updated: 2022-01-06T06:55:33Z department: - _id: '9' - _id: '145' language: - iso: eng place: online (Leipzig) publisher: Jahrestreffen der ProcessNet-Fachgruppen Fluidverfahrenstechnik und Wärme- und Stoffübertragung status: public title: Dynamische Simulation von Gefahrensituationen bei industriellen Kreislaufprozessen am Beispiel der chemischen Absorption type: conference_abstract user_id: '22006' year: '2021' ... --- _id: '22511' abstract: - lang: eng text: "In this paper, we reconsider the well-known discrete, round-based Go-To-The-Center algorithm due to Ando, Suzuki, and Yamashita [2] for gathering n autonomous mobile robots with limited viewing range in the plane. Remarquably, this algorithm exploits the fact that during its execution, many collisions of robots occur. Such collisions are interpreted as a success because it is assumed that such collided robots behave the same from now on. This is acceptable under the assumption that each robot is represented by a single point. Otherwise, collisions should be avoided. In this paper, we consider a continuous Go-To-The-Center algorithm in which the robots continuously observe the positions of their neighbors and adapt their speed (assuming a speed limit) and direction. Our first results are time bounds of O(n2) for gathering in two dimensions Euclidean space, and Θ(n) for the one dimension. Our main contribution is the introduction and evaluation of a continuous algorithm which performs Go-To-The-Center considering only the neighbors of a robot with respect to the Gabriel subgraph of the visibility graph, i.e. Go-To-The-Gabriel-Center algorithm. We show that this modification still correctly executes gathering in one and two dimensions, with the same time bounds as above. Simulations exhibit a severe difference of the behavior of the Go-To-The-Center and the Go-To-The-Gabriel-Center algorithms: Whereas lots of collisions occur during a run of the Go-To-The-Center algorithm, typically only one, namely the final collision occurs during a run of the Go-To-The-Gabriel-Center algorithm. We can prove this “collisionless property” of the Go-To-The-Gabriel-Center algorithm for one dimension. In two-dimensional Euclidean space, we conjecture that the “collisionless property” holds for almost every initial configuration. We support our conjecture with measurements obtained from the simulation where robots execute both continuous Go-To-The-Center and Go-To-The-Gabriel-Center algorithms.\r\n" author: - first_name: Shouwei full_name: Li, Shouwei last_name: Li - first_name: Friedhelm full_name: Meyer auf der Heide, Friedhelm id: '15523' last_name: Meyer auf der Heide - first_name: Pavel full_name: Podlipyan, Pavel last_name: Podlipyan citation: ama: Li S, Meyer auf der Heide F, Podlipyan P. The impact of the Gabriel subgraph of the visibility graph on the gathering of mobile autonomous robots. Theoretical Computer Science. 2021;852:29-40. doi:10.1016/j.tcs.2020.11.009 apa: Li, S., Meyer auf der Heide, F., & Podlipyan, P. (2021). The impact of the Gabriel subgraph of the visibility graph on the gathering of mobile autonomous robots. Theoretical Computer Science, 852, 29–40. https://doi.org/10.1016/j.tcs.2020.11.009 bibtex: '@article{Li_Meyer auf der Heide_Podlipyan_2021, title={The impact of the Gabriel subgraph of the visibility graph on the gathering of mobile autonomous robots}, volume={852}, DOI={10.1016/j.tcs.2020.11.009}, journal={Theoretical Computer Science}, author={Li, Shouwei and Meyer auf der Heide, Friedhelm and Podlipyan, Pavel}, year={2021}, pages={29–40} }' chicago: 'Li, Shouwei, Friedhelm Meyer auf der Heide, and Pavel Podlipyan. “The Impact of the Gabriel Subgraph of the Visibility Graph on the Gathering of Mobile Autonomous Robots.” Theoretical Computer Science 852 (2021): 29–40. https://doi.org/10.1016/j.tcs.2020.11.009.' ieee: S. Li, F. Meyer auf der Heide, and P. Podlipyan, “The impact of the Gabriel subgraph of the visibility graph on the gathering of mobile autonomous robots,” Theoretical Computer Science, vol. 852, pp. 29–40, 2021. mla: Li, Shouwei, et al. “The Impact of the Gabriel Subgraph of the Visibility Graph on the Gathering of Mobile Autonomous Robots.” Theoretical Computer Science, vol. 852, 2021, pp. 29–40, doi:10.1016/j.tcs.2020.11.009. short: S. Li, F. Meyer auf der Heide, P. Podlipyan, Theoretical Computer Science 852 (2021) 29–40. date_created: 2021-06-28T09:34:45Z date_updated: 2022-01-06T06:55:35Z department: - _id: '63' doi: 10.1016/j.tcs.2020.11.009 intvolume: ' 852' keyword: - Local algorithms - Distributed algorithms - Collisionless gathering - Mobile robots - Multiagent system language: - iso: eng page: 29-40 publication: Theoretical Computer Science publication_identifier: issn: - 0304-3975 publication_status: published status: public title: The impact of the Gabriel subgraph of the visibility graph on the gathering of mobile autonomous robots type: journal_article user_id: '15415' volume: 852 year: '2021' ... --- _id: '22637' abstract: - lang: eng text: "Abstract\r\n Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers." author: - first_name: Heini full_name: Ijäs, Heini last_name: Ijäs - first_name: Boxuan full_name: Shen, Boxuan last_name: Shen - first_name: Amelie full_name: Heuer-Jungemann, Amelie last_name: Heuer-Jungemann - first_name: Adrian full_name: Keller, Adrian id: '48864' last_name: Keller orcid: 0000-0001-7139-3110 - first_name: Mauri A full_name: Kostiainen, Mauri A last_name: Kostiainen - first_name: Tim full_name: Liedl, Tim last_name: Liedl - first_name: Janne A full_name: Ihalainen, Janne A last_name: Ihalainen - first_name: Veikko full_name: Linko, Veikko last_name: Linko citation: ama: Ijäs H, Shen B, Heuer-Jungemann A, et al. Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. Nucleic Acids Research. 2021;49:3048-3062. doi:10.1093/nar/gkab097 apa: Ijäs, H., Shen, B., Heuer-Jungemann, A., Keller, A., Kostiainen, M. A., Liedl, T., … Linko, V. (2021). Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. Nucleic Acids Research, 49, 3048–3062. https://doi.org/10.1093/nar/gkab097 bibtex: '@article{Ijäs_Shen_Heuer-Jungemann_Keller_Kostiainen_Liedl_Ihalainen_Linko_2021, title={Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release}, volume={49}, DOI={10.1093/nar/gkab097}, journal={Nucleic Acids Research}, author={Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann, Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen, Janne A and Linko, Veikko}, year={2021}, pages={3048–3062} }' chicago: 'Ijäs, Heini, Boxuan Shen, Amelie Heuer-Jungemann, Adrian Keller, Mauri A Kostiainen, Tim Liedl, Janne A Ihalainen, and Veikko Linko. “Unraveling the Interaction between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” Nucleic Acids Research 49 (2021): 3048–62. https://doi.org/10.1093/nar/gkab097.' ieee: H. Ijäs et al., “Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release,” Nucleic Acids Research, vol. 49, pp. 3048–3062, 2021. mla: Ijäs, Heini, et al. “Unraveling the Interaction between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” Nucleic Acids Research, vol. 49, 2021, pp. 3048–62, doi:10.1093/nar/gkab097. short: H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M.A. Kostiainen, T. Liedl, J.A. Ihalainen, V. Linko, Nucleic Acids Research 49 (2021) 3048–3062. date_created: 2021-07-08T11:46:53Z date_updated: 2022-01-06T06:55:37Z department: - _id: '302' doi: 10.1093/nar/gkab097 intvolume: ' 49' language: - iso: eng page: 3048-3062 publication: Nucleic Acids Research publication_identifier: issn: - 0305-1048 - 1362-4962 publication_status: published status: public title: Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release type: journal_article user_id: '48864' volume: 49 year: '2021' ... --- _id: '22807' abstract: - lang: eng text: "Photonic quantum technologies [1] with applications in quantum\r\ncommunication, sensing as well as quantum simulation and computing, are on the\r\nverge of becoming commercially available. One crucial building block are\r\ntailored nanoscale integratable quantum light sources, matching the specific\r\nneeds of use-cases. Several different approaches to realize solid-state quantum\r\nemitters [2] with high performance [3] have been pursued. However, the\r\nproperties of the emitted single photons are always defined by the individual\r\nquantum light source and despite numerous quantum emitter tuning\r\ntechniques [4-7], scalability is still a major challenge. Here we show an\r\nemitter-independent method to tailor and control the properties of the single\r\nphoton emission. We demonstrate a laser-controlled down-conversion process from\r\nan excited state of a quantum three-level system [8]. Starting from a biexciton\r\nstate, a tunable control laser field defines a virtual state in a stimulated\r\nprocess. From there, spontaneous emission to the ground state leads to\r\noptically controlled single photon emission. Based on this concept, we\r\ndemonstrate energy tuning of the single photon emission with a control laser\r\nfield. The nature of the involved quantum states furthermore provides a unique\r\nbasis for the future control of polarization and bandwidth, as predicted by\r\ntheory [9,10]. Our demonstration marks an important step towards tailored\r\nsingle photon emission from a photonic quantum system based on quantum optical\r\nprinciples." author: - first_name: B. full_name: Jonas, B. last_name: Jonas - first_name: D. full_name: Heinze, D. last_name: Heinze - first_name: E. full_name: Schöll, E. last_name: Schöll - first_name: P. full_name: Kallert, P. last_name: Kallert - first_name: T. full_name: Langer, T. last_name: Langer - first_name: S. full_name: Krehs, S. last_name: Krehs - first_name: A. full_name: Widhalm, A. last_name: Widhalm - first_name: K. D. full_name: Jöns, K. D. last_name: Jöns - first_name: D. full_name: Reuter, D. last_name: Reuter - first_name: S. full_name: Schumacher, S. last_name: Schumacher - first_name: Artur full_name: Zrenner, Artur id: '606' last_name: Zrenner orcid: 0000-0002-5190-0944 citation: ama: Jonas B, Heinze D, Schöll E, et al. Nonlinear down-conversion in a single quantum dot. arXiv:210512393. 2021. apa: Jonas, B., Heinze, D., Schöll, E., Kallert, P., Langer, T., Krehs, S., … Zrenner, A. (2021). Nonlinear down-conversion in a single quantum dot. ArXiv:2105.12393. bibtex: '@article{Jonas_Heinze_Schöll_Kallert_Langer_Krehs_Widhalm_Jöns_Reuter_Schumacher_et al._2021, title={Nonlinear down-conversion in a single quantum dot}, journal={arXiv:2105.12393}, author={Jonas, B. and Heinze, D. and Schöll, E. and Kallert, P. and Langer, T. and Krehs, S. and Widhalm, A. and Jöns, K. D. and Reuter, D. and Schumacher, S. and et al.}, year={2021} }' chicago: Jonas, B., D. Heinze, E. Schöll, P. Kallert, T. Langer, S. Krehs, A. Widhalm, et al. “Nonlinear Down-Conversion in a Single Quantum Dot.” ArXiv:2105.12393, 2021. ieee: B. Jonas et al., “Nonlinear down-conversion in a single quantum dot,” arXiv:2105.12393. 2021. mla: Jonas, B., et al. “Nonlinear Down-Conversion in a Single Quantum Dot.” ArXiv:2105.12393, 2021. short: B. Jonas, D. Heinze, E. Schöll, P. Kallert, T. Langer, S. Krehs, A. Widhalm, K.D. Jöns, D. Reuter, S. Schumacher, A. Zrenner, ArXiv:2105.12393 (2021). date_created: 2021-07-25T12:45:25Z date_updated: 2022-01-06T06:55:42Z ddc: - '530' department: - _id: '15' - _id: '230' file: - access_level: closed content_type: application/pdf creator: zrenner date_created: 2021-07-25T12:46:24Z date_updated: 2021-07-25T12:46:24Z file_id: '22808' file_name: 2105.12393.pdf file_size: 1786455 relation: main_file success: 1 file_date_updated: 2021-07-25T12:46:24Z has_accepted_license: '1' language: - iso: eng publication: arXiv:2105.12393 status: public title: Nonlinear down-conversion in a single quantum dot type: preprint user_id: '606' year: '2021' ... --- _id: '22927' author: - first_name: John full_name: Derrick, John last_name: Derrick - first_name: Simon full_name: Doherty, Simon last_name: Doherty - first_name: Brijesh full_name: Dongol, Brijesh last_name: Dongol - first_name: Gerhard full_name: Schellhorn, Gerhard last_name: Schellhorn - first_name: Heike full_name: Wehrheim, Heike id: '573' last_name: Wehrheim citation: ama: 'Derrick J, Doherty S, Dongol B, Schellhorn G, Wehrheim H. On Strong Observational Refinement and Forward Simulation. In: Proceedings of the 35th International Symposium on Distributed Computing (DISC). Leibniz International Proceedings in Informatics. Schloß Dagstuhl.' apa: Derrick, J., Doherty, S., Dongol, B., Schellhorn, G., & Wehrheim, H. (n.d.). On Strong Observational Refinement and Forward Simulation. In Proceedings of the 35th International Symposium on Distributed Computing (DISC). Schloß Dagstuhl. bibtex: '@inproceedings{Derrick_Doherty_Dongol_Schellhorn_Wehrheim, series={Leibniz International Proceedings in Informatics}, title={On Strong Observational Refinement and Forward Simulation}, booktitle={Proceedings of the 35th International Symposium on Distributed Computing (DISC)}, publisher={Schloß Dagstuhl}, author={Derrick, John and Doherty, Simon and Dongol, Brijesh and Schellhorn, Gerhard and Wehrheim, Heike}, collection={Leibniz International Proceedings in Informatics} }' chicago: Derrick, John, Simon Doherty, Brijesh Dongol, Gerhard Schellhorn, and Heike Wehrheim. “On Strong Observational Refinement and Forward Simulation.” In Proceedings of the 35th International Symposium on Distributed Computing (DISC). Leibniz International Proceedings in Informatics. Schloß Dagstuhl, n.d. ieee: J. Derrick, S. Doherty, B. Dongol, G. Schellhorn, and H. Wehrheim, “On Strong Observational Refinement and Forward Simulation,” in Proceedings of the 35th International Symposium on Distributed Computing (DISC). mla: Derrick, John, et al. “On Strong Observational Refinement and Forward Simulation.” Proceedings of the 35th International Symposium on Distributed Computing (DISC), Schloß Dagstuhl. short: 'J. Derrick, S. Doherty, B. Dongol, G. Schellhorn, H. Wehrheim, in: Proceedings of the 35th International Symposium on Distributed Computing (DISC), Schloß Dagstuhl, n.d.' date_created: 2021-08-03T07:38:56Z date_updated: 2022-01-06T06:55:43Z department: - _id: '7' language: - iso: eng project: - _id: '1' name: SFB 901 - _id: '3' name: SFB 901 - Project Area B - _id: '12' name: SFB 901 - Subproject B4 publication: Proceedings of the 35th International Symposium on Distributed Computing (DISC) publication_status: accepted publisher: Schloß Dagstuhl series_title: Leibniz International Proceedings in Informatics status: public title: On Strong Observational Refinement and Forward Simulation type: conference user_id: '477' year: '2021' ...