@article{54944, abstract = {{The epithelial sodium channel (ENaC) is probably a heterotrimer with three well characterized subunits (alphabetagamma). In humans an additional delta-subunit (delta-hENaC) exists but little is known about its function. Using the Xenopus laevis oocyte expression system, we compared the functional properties of alphabetagamma- and deltabetagamma-hENaC and investigated whether deltabetagamma-hENaC can be proteolytically activated. The amiloride-sensitive ENaC whole-cell current (DeltaI(ami)) was about 11-fold larger in oocytes expressing deltabetagamma-hENaC than in oocytes expressing alphabetagamma-hENaC. The 2-fold larger single-channel Na(+) conductance of deltabetagamma-hENaC cannot explain this difference. Using a chemiluminescence assay, we demonstrated that an increased channel surface expression is also not the cause. Thus, overall channel activity of deltabetagamma-hENaC must be higher than that of alphabetagamma-hENaC. Experiments exploiting the properties of the known betaS520C mutant ENaC confirmed this conclusion. Moreover, chymotrypsin had a reduced stimulatory effect on deltabetagamma-hENaC whole-cell currents compared with its effect on alphabetagamma-hENaC whole-cell currents (2-fold versus 5-fold). This suggests that the cell surface pool of so-called near-silent channels that can be proteolytically activated is smaller for deltabetagamma-hENaC than for alphabetagamma-hENaC. Proteolytic activation of deltabetagamma-hENaC was associated with the appearance of a delta-hENaC cleavage product at the cell surface. Finally, we demonstrated that a short inhibitory 13-mer peptide corresponding to a region of the extracellular loop of human alpha-ENaC inhibited DeltaI(ami) in oocytes expressing alphabetagamma-hENaC but not in those expressing deltabetagamma-hENaC. We conclude that the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity.}}, author = {{Haerteis, Silke and Krueger, Bettina and Korbmacher, Christoph and Rauh, Robert}}, journal = {{Journal of Biological Chemistry}}, number = {{42}}, pages = {{29024–29040}}, publisher = {{American Society for Biochemistry and Molecular Biology}}, title = {{{The $\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation}}}, doi = {{10.1074/jbc.m109.018945}}, volume = {{284}}, year = {{2009}}, } @article{54938, abstract = {{The lipid environment of the epithelial sodium channel (ENaC) and its possible association with so-called lipid rafts may be relevant to its function. The aim of our study was to confirm the association of ENaC with lipid rafts and to analyze the effect of cholesterol depletion of the plasma membrane by methyl-beta-cyclodextrin (MbetaCD) on channel function and regulation. Using sucrose density gradient centrifugation we demonstrated that a significant portion of ENaC protein distributes to low density fractions thought to be typical lipid raft fractions. Importantly, cholesterol depletion of cell lysate by MbetaCD shifted ENaC to non-raft fractions of higher density. Live cell imaging demonstrated that treatment with MbetaCD largely reduced filipin staining over time, confirming cholesterol depletion of the plasma membrane. For electrophysiological studies intact oocytes were exposed to 20 mM MbetaCD for three hours. MbetaCD treatment had no consistent effect on baseline whole-cell ENaC currents. In addition to the typical single channel conductance of about 5 pS, subconductance states of ENaC were occasionally observed in patches from MbetaCD treated but not from control oocytes. Importantly, in outside-out patch clamp recordings the stimulatory effect of recombinant SGK1 in the pipette solution was essentially abolished in oocytes pretreated with MbetaCD. These results indicate that ENaC activation by cytosolic SGK1 is compromised by removing cholesterol from the plasma membrane. Thus, ENaC activation by SGK1 may require the presence of an intact lipid environment and/or of lipid rafts as signalling platform.}}, author = {{Krueger, Bettina and Haerteis, Silke and Yang, Limin and Hartner, Andrea and Rauh, Robert and Korbmacher, Christoph and Diakov, Alexei}}, journal = {{Cellular Physiology and Biochemistry}}, number = {{5-6}}, pages = {{605–618}}, publisher = {{S. Karger AG}}, title = {{{Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1}}}, doi = {{10.1159/000257516}}, volume = {{24}}, year = {{2009}}, } @article{54945, abstract = {{We describe a programming scheme for massively distributed systems that are assumed to self-organize according to a given set of simple rules. The focus of this investigation is operation and control in Sensor and Actor Networks (SANETs). The main issues addressed by self-organization techniques are scalability, network lifetime, and real-time support. In the literature, biological principles are often cited as inspirations for technical solutions, especially in the domain of self-organization. We developed a system named Rule-based Sensor Network (RSN) according to the observed communication and control behavior in cellular communication. Cellular signaling cascades allow the event-specific reaction initiated by individual cells in collaboration with their direct neighbors. Information between cells are transmitted via proteins and result in the cascade of protein-protein or protein-DNA interactions to produce a specific cellular answer, e.g. the activation of cells or the transmission of mediators. These processes are programmed in every individual cell and lead to a coordinated reaction on a higher organization platform. We transferred these mechanisms to operation and control in SANETs. In particular, a rule-based processing scheme relying on the main concepts of cellular signaling cascades has been developed. It relies on simple local rules and provides problem specific reaction such as local actuation control and data manipulation. We describe this RSN technology and demonstrate comparative simulation results that show the feasibility of our approach.}}, author = {{Dressler, Falko and Dietrich, Isabel and German, Reinhard and Krueger, Bettina}}, issn = {{1389-1286}}, journal = {{Elsevier Computer Networks}}, number = {{10}}, pages = {{1737–1750}}, publisher = {{Elsevier}}, title = {{{A Rule-based System for Programming Self-Organized Sensor and Actor Networks}}}, doi = {{10.1016/j.comnet.2008.09.007}}, volume = {{53}}, year = {{2009}}, } @article{36050, author = {{Schlegel-Matthies, Kirsten and Methfessel, Barbara and Bigga, Regine}}, issn = {{0342-5088}}, journal = {{Haushalt & Bildung}}, number = {{2}}, pages = {{10--14}}, publisher = {{Schneider-Verlag}}, title = {{{Materielle Ressourcen – oder: Warum, wozu und wie haben und nutzen wir Güter?}}}, volume = {{86}}, year = {{2009}}, } @article{40220, author = {{Wagenknecht, Inga and Meier-Gräwe, Uta and Fegert, Jörg M.}}, issn = {{0721-9121}}, journal = {{Frühförderung interdisziplinär}}, pages = {{82--91}}, title = {{{Frühe Hilfen rechnen sich}}}, volume = {{28}}, year = {{2009}}, } @inproceedings{44069, abstract = {{Recently it has been shown experimentally that it is possible to coherently control nano-optical excitations by using sophisticated shaped laser pulses. In this work a similar technique is used to theoretically investigate a hybrid nanostructure which consists of a metal aperture and a quantum wire. It is shown that one can concentrate the optically excited electron density at an arbitrary position due to wave packet dynamics by chosing particular frequency components and phases of the chirped laser pulse. The optimization process is performed with a genetic algorithm which is linked to a 3D-FDTD solver.}}, author = {{Meier, Torsten and Reichelt, Matthias}}, booktitle = {{DPG Spring meeting 2009}}, issn = {{0420-0195}}, location = {{Dresden, Germany}}, number = {{5}}, title = {{{Coherent control in hybrid metal-semiconductor nanostructures}}}, volume = {{44}}, year = {{2009}}, } @book{25839, author = {{Parisi, Salvatore}}, publisher = {{Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn}}, title = {{{A Method for the intelligent Authoring of 3D Animations for Traimimg and Maintenance}}}, volume = {{228}}, year = {{2008}}, } @article{25938, author = {{Karaolis-Danckert, N and Buyken, Anette and Kulig, M and Kroke, A and Forster, J and Kamin, W and Schuster, A and Hornberg, C and Keil, T and Bergmann, RL and Wahn, U and Lau, S}}, issn = {{0002-9165}}, journal = {{Am J Clin Nutr}}, number = {{5}}, pages = {{1356--1364}}, title = {{{How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90.}}}, doi = {{10.1093/ajcn/87.5.1356}}, volume = {{87}}, year = {{2008}}, } @article{26891, author = {{Buyken, Anette and Karaolis-Danckert, Nadina and Remer, Thomas}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, pages = {{221--230}}, title = {{{Association of prepubertal body composition in healthy girls and boys with the timing of early and late pubertal markers}}}, doi = {{10.3945/ajcn.2008.26733}}, year = {{2008}}, } @article{26892, author = {{Libuda, Lars and Alexy, Ute and Buyken, Anette and Sichert-Hellert, Wolfgang and Stehle, Peter and Kersting, Mathilde}}, issn = {{0007-1145}}, journal = {{British Journal of Nutrition}}, title = {{{Consumption of sugar-sweetened beverages and its association with nutrient intakes and diet quality in German children and adolescents}}}, doi = {{10.1017/s0007114508094671}}, year = {{2008}}, } @article{27137, author = {{Libuda, Lars and Alexy, Ute and Remer, Thomas and Stehle, Peter and Schoenau, Eckhard and Kersting, Mathilde}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, pages = {{1670--1677}}, title = {{{Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents}}}, doi = {{10.3945/ajcn.2008.26414}}, year = {{2008}}, } @article{27586, author = {{Libuda, Lars and Alexey, U. and Stehle, P. and Kersting, M.}}, journal = {{Aktuelle Ernährungsmedizin}}, pages = {{123--131}}, title = {{{Konsum von Erfrischungsgetränken und Entwicklung des Körpergewichts im Kindes- und Jugendalter – Gibt es eine Verbindung? }}}, doi = {{10.1055/s-2007-986311}}, volume = {{33}}, year = {{2008}}, } @article{27587, author = {{Libuda, Lars and Kersting, M.}}, journal = {{Ernährungsumschau}}, pages = {{646}}, title = {{{DONALD News: Erfrischungsgetränke und Ernährungsqualität. }}}, volume = {{55}}, year = {{2008}}, } @article{27714, author = {{Buyken, Anette and Karaolis-Danckert, Nadina and Remer, Thomas and Bolzenius, Katja and Landsberg, Beate and Kroke, Anja}}, issn = {{1930-7381}}, journal = {{Obesity}}, pages = {{389--395}}, title = {{{Effects of Breastfeeding on Trajectories of Body Fat and BMI throughout Childhood}}}, doi = {{10.1038/oby.2007.57}}, year = {{2008}}, } @article{27773, author = {{Toeller, M. and Buyken, Anette and Heitkamp, G. and Berg, G. and Scherbaum, W.}}, issn = {{0018-5043}}, journal = {{Hormone and Metabolic Research}}, pages = {{680--685}}, title = {{{Prevalence of Chronic Complications, Metabolic Control and Nutritional Intake in Type 1 Diabetes: Comparison Between Different European Regions}}}, doi = {{10.1055/s-2007-978820}}, year = {{2008}}, } @inbook{27887, author = {{Schlegel-Matthies, Kirsten}}, booktitle = {{Ernährung, Kultur, Lebensqualität. Wege regionaler Nachhaltigkeit}}, editor = {{Antoni-Komar, I. and Pfriem, R. and Raabe, T. and Spiller, A.}}, pages = {{303--315}}, title = {{{Ernährungsbildung in Unterricht und Schulprofil. Essen und Trinken in der Schule – Bildungschance und Beitrag zu sozialer Gerechtigkeit}}}, year = {{2008}}, } @inbook{27888, author = {{Methfessel, B. and Ritterbach, U. and Schlegel-Matthies, Kirsten}}, booktitle = {{.): Schwer messbare Kompetenzen. Herausforderungen für die empirische Fachdidaktik}}, editor = {{Frederking, V.}}, pages = {{115--125}}, title = {{{Private Lebensführung als Umgang mit Komplexität - ein schwer operationalisierbares Bildungsziel}}}, year = {{2008}}, } @inproceedings{17868, abstract = {{The paper describes an approach for an aggregated animation of a simulation experiment in an interactive 3D environment, visualizing multiple, distributed simulation runs. Although the general approach of a 3-dimensional visualization of material flow simulation helps to understand the dynamic behavior of a system better as well as faster, it remains unclear, how typical the animated simulation represents the model, if there is a stochastic influence for even some parameters. By the integrated visualization of multiple distributed simulation runs, this uncertainty can be solved, which will be shown in this paper for a typical simulation study of a queuing system. }}, author = {{Dangelmaier, Wilhelm and Fischer, Matthias and Huber, Daniel and Laroque, Christoph and Suess, Tim}}, booktitle = {{2008 Winter Simulation Conference}}, isbn = {{9781424427079}}, pages = {{2012--2020}}, title = {{{Aggregated 3D-visualization of a distributed simulation experiment of a queuing system}}}, doi = {{10.1109/wsc.2008.4736296}}, year = {{2008}}, } @inproceedings{1940, author = {{Mense, Mario and Scheideler, Christian}}, booktitle = {{Proceedings of the Nineteenth Annual ACM-SIAM Symposium on Discrete Algorithms, SODA 2008, San Francisco, California, USA, January 20-22, 2008}}, pages = {{1135----1144}}, publisher = {{SIAM}}, title = {{{SPREAD: an adaptive scheme for redundant and fair storage in dynamic heterogeneous storage systems}}}, year = {{2008}}, } @inproceedings{18139, abstract = {{This paper describes a method for the animation of a large number of objects within a dynamic 3D visualization of a material flow simulation model. It uses key-frame based animation. The number of animated objects may grow constantly in complex simulation models, which might lead to an amount of animations that is too big to be computed in real-time. By the use of a dynamic adjustment, the presented algorithm prefers important animations. Less relevant animations are updated rarely, whereby the selection itself is taken by multiple indicators, e.g. the visible size of the animated object on the screen, in order to keep a good optical impression. Dependent on the computing power of the computer, the algorithm controls the animations in such a way, that the fluid visualization of a large number of objects is still possible. Though the algorithm is to be used within a material flow simulator, it is moreover implemented in a specific animation editor, which allows the design and control of animation schemes. It supports the use of grouping to allow the creation of hierarchical structures for complex animations in a fast and easy manner. The evaluation of the algorithm is proven by a test scene, consisting of tens of thousands animated objects. }}, author = {{Laroque, Christoph and Fischer, Matthias and Dangelmaier, Wilhelm and Eikel, Benjamin}}, booktitle = {{Industrial Simulation Conference (ISC 2008)}}, pages = {{306--310}}, publisher = {{EUROSIS-ETI}}, title = {{{Dynamic Control of Animation Schemes for the Efficient 3D-Visualization of Material Flow Simulations}}}, year = {{2008}}, }